9601:FAM57B
gene id: 9601:FAM57B
uniprot id: H2NQK7
names: Subcellular Location Annotation
messages: Membrane

9601:GNPAT
gene id: 9601:GNPAT
uniprot id: Q5R963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9601:GSC2
gene id: 9601:GSC2
uniprot id: H2P3L6
names: Subcellular Location Annotation
messages: Nucleus

9601:TMEM45A
gene id: 9601:TMEM45A
uniprot id: A0A2J8T8T3
uniprot id: H2P9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9601:AIPL1
gene id: 9601:AIPL1
uniprot id: A0A2J8RXB9
uniprot id: A0A2J8RXD0
uniprot id: A0A2J8RXF7
uniprot id: A0A2J8RXG3
uniprot id: A0A2J8RXI7
uniprot id: A0A2J8RXJ8
uniprot id: H2NSF5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PIGK
gene id: 9601:PIGK
uniprot id: Q5R6L8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).
messages: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.

9601:SARNP
gene id: 9601:SARNP
uniprot id: Q5R4V4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4.
messages: Nucleus
messages: Nucleus speckle

9601:CD151
gene id: 9601:CD151
uniprot id: A0A6D2W131
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9601:DNAJB12
gene id: 9601:DNAJB12
uniprot id: A0A6D2Y8N6
names: Subcellular Location Annotation
messages: Membrane

9601:ARHGEF10L
gene id: 9601:ARHGEF10L
uniprot id: Q5R5M3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
messages: Cytoplasm
messages: Interacts with RHOA, RHOB and RHOC.

9601:NLRP11
gene id: 9601:NLRP11
uniprot id: H2P095
names: Similarity
messages: Belongs to the NLRP family.

9601:RGS6
gene id: 9601:RGS6
uniprot id: A0A2J8T4I4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHAX
gene id: 9601:PHAX
uniprot id: A0A663DGT3
uniprot id: H2PGE1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DCX
gene id: 9601:DCX
uniprot id: A0A2J8VAG0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CD3G
gene id: 9601:CD3G
uniprot id: H2NFG8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9601:PTHLH
gene id: 9601:PTHLH
uniprot id: A0A2J8WBT7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9601:ACAT1
gene id: 9601:ACAT1
uniprot id: H2NF71
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9601:CNN3
gene id: 9601:CNN3
uniprot id: H2N6Q1
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9601:AIF1L
gene id: 9601:AIF1L
uniprot id: Q5RDI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity).
messages: Homodimer (Potential). Monomer (By similarity).
messages: cytoskeleton
messages: ruffle membrane

9601:CYR61
gene id: 9601:CYR61
uniprot id: H2N6W3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:CREB5
gene id: 9601:CREB5
uniprot id: A0A2J8VDP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9601:COX7C
gene id: 9601:COX7C
uniprot id: A0A6D2XPD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9601:KCNK6
gene id: 9601:KCNK6
uniprot id: A0A6D2W7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9601:CFAP53
gene id: 9601:CFAP53
uniprot id: H2NWC4
names: Similarity
messages: Belongs to the CFAP53 family.

9601:PFKFB2
gene id: 9601:PFKFB2
uniprot id: Q5NVT1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Phosphorylation by AMPK stimulates activity.
messages: Phosphorylation results in the activation of the kinase activity.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.

9601:RAMP3
gene id: 9601:RAMP3
uniprot id: A0A6D2W015
names: Similarity
messages: Belongs to the RAMP family.

9601:ATP6V0A1
gene id: 9601:ATP6V0A1
uniprot id: Q5R5X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9601:MYCBP
gene id: 9601:MYCBP
uniprot id: A0A2J8Y6H7
uniprot id: Q5R7A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AMY1 family.
messages: Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP. Interacts with CFAP91.
messages: Cytoplasm
messages: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WASHC5
gene id: 9601:WASHC5
uniprot id: A0A2J8X2J7
uniprot id: Q5R5P0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity).
messages: Belongs to the strumpellin family.
messages: Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VCP, PI4K2A (By similarity).
messages: Early endosome
messages: Endoplasmic reticulum
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:AGA
gene id: 9601:AGA
uniprot id: H2PET4
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9601:HCFC1R1
gene id: 9601:HCFC1R1
uniprot id: A0A2J8S7W9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM216A
gene id: 9601:FAM216A
uniprot id: H2NIM5
names: Similarity
messages: Belongs to the FAM216 family.

9601:LOC100459356
gene id: 9601:LOC100459356
uniprot id: A0A663D6K3
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9601:NEFL
gene id: 9601:NEFL
uniprot id: Q5R408
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFH or NEFM; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Interacts with ARHGEF28. Interacts with TRIM2.
messages: NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homomeric 10-nm filaments.
messages: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
messages: Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
messages: Ubiquitinated in the presence of TRIM2 and UBE2D1.
messages: axon
messages: cytoskeleton

9601:C19H19orf12
gene id: 9601:C19H19orf12
uniprot id: A0A2J8SAC8
uniprot id: A0A2J8SAE3
uniprot id: A0A6D2X6I9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZBTB8OS
gene id: 9601:ZBTB8OS
uniprot id: A0A6D2XUL2
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9601:SLC25A32
gene id: 9601:SLC25A32
uniprot id: Q5RFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:METTL7B
gene id: 9601:METTL7B
uniprot id: A0A6D2W479
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SSBP2
gene id: 9601:SSBP2
uniprot id: A0A663DCA3
uniprot id: H2PG08
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100447981
gene id: 9601:LOC100447981
uniprot id: H2NFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:LHFPL2
gene id: 9601:LHFPL2
uniprot id: A0A6D2X0V2
names: Subcellular Location Annotation
messages: Membrane

9601:OTC
gene id: 9601:OTC
uniprot id: H2PVB0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9601:PNKD
gene id: 9601:PNKD
uniprot id: A0A2J8TTY1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9601:SSR3
gene id: 9601:SSR3
uniprot id: A0A2J8WTA6
uniprot id: Q5RCD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COX18
gene id: 9601:COX18
uniprot id: A0A2J8UTU7
uniprot id: Q5R7D0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX20, SCO1 and SCO2. Interacts transiently with MT-CO2/COX2 during its maturation. Interacts with COX20 in a MT-CO2/COX2-dependent manner.
messages: Membrane
messages: Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TNMD
gene id: 9601:TNMD
uniprot id: H2PW84
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9601:PTPN6
gene id: 9601:PTPN6
uniprot id: A0A2J8TBK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9601:NR2C2
gene id: 9601:NR2C2
uniprot id: A0A2J8TVP0
uniprot id: H2P9C3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHYKPL
gene id: 9601:PHYKPL
uniprot id: H2PHJ8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9601:LSM6
gene id: 9601:LSM6
uniprot id: A0A6D2WZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9601:FLCN
gene id: 9601:FLCN
uniprot id: H2NSW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9601:XCL1
gene id: 9601:XCL1
uniprot id: H2N4T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9601:TUSC3
gene id: 9601:TUSC3
uniprot id: A0A6D2VSE4
uniprot id: H2PPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SLC30A6
gene id: 9601:SLC30A6
uniprot id: A0A2J8VNJ1
uniprot id: H2P6J4
uniprot id: Q5RDP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IFT20
gene id: 9601:IFT20
uniprot id: H2NT27
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9601:CRB1
gene id: 9601:CRB1
uniprot id: A0A2J8UXW1
uniprot id: A0A2J8UXX1
uniprot id: A0A2J8UXX4
uniprot id: H2N4A7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:TRHR
gene id: 9601:TRHR
uniprot id: A0A6D2Y327
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9601:ITM2C
gene id: 9601:ITM2C
uniprot id: A0A2J8TQI0
uniprot id: Q5NVC3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Cell membrane
messages: Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).
messages: Lysosome membrane
messages: Membrane
messages: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity).

9601:CLDN6
gene id: 9601:CLDN6
uniprot id: A0A6D2VS87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:FNBP1L
gene id: 9601:FNBP1L
uniprot id: A0A2J8VCV0
uniprot id: A0A2J8VCV6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9601:PON3
gene id: 9601:PON3
uniprot id: H2PMW1
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9601:TSPYL5
gene id: 9601:TSPYL5
uniprot id: H2PQV5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9601:GPR83
gene id: 9601:GPR83
uniprot id: A0A663DIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9601:LOC100440265
gene id: 9601:LOC100440265
uniprot id: H2N805
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9601:CCDC126
gene id: 9601:CCDC126
uniprot id: A0A2J8VE15
uniprot id: A0A6D2Y3E1
names: Caution
names: Subcellular Location Annotation
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MORC3
gene id: 9601:MORC3
uniprot id: A0A663DCH1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TH
gene id: 9601:TH
uniprot id: A0A2J8S6N3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9601:LOC100452761
gene id: 9601:LOC100452761
uniprot id: H2NGX7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:LSM2
gene id: 9601:LSM2
uniprot id: H2PIK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9601:ZNF148
gene id: 9601:ZNF148
uniprot id: Q5R782
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP. Interacts with CAVIN1.
messages: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes (By similarity).
messages: Nucleus
messages: Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).

9601:PSME3
gene id: 9601:PSME3
uniprot id: A0A2J8RES6
uniprot id: Q5RFD3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).
messages: Belongs to the PA28 family.
messages: Cytoplasm
messages: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53, MDM2 and MAP3K3. Associates with the proteasome. Interacts with CCAR2. Interacts with PSME3IP1 (via C-terminus); the interaction is direct and promotes the association of PSME3 with the 20S proteasome. Interacts with COIL; the interaction is inhibited by PSME3IP1.
messages: Nucleus
messages: Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2.
messages: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity).
messages: The C-terminal sequences affect heptamer stability and proteasome affinity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPS21
gene id: 9601:RPS21
uniprot id: A0A2J8RB82
uniprot id: H2P2I6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:LOC100440314
gene id: 9601:LOC100440314
uniprot id: A0A2J8T1Q0
names: Function
names: Similarity
messages: Belongs to the VCX/VCY family.
messages: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

9601:NDUFA1
gene id: 9601:NDUFA1
uniprot id: Q5R5K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:UXT
gene id: 9601:UXT
uniprot id: A0A6D2WE39
uniprot id: H2PVH1
names: Similarity
messages: Belongs to the UXT family.

9601:ZNF573
gene id: 9601:ZNF573
uniprot id: A0A2J8RE98
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLK1
gene id: 9601:PLK1
uniprot id: H2NQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9601:GOSR2
gene id: 9601:GOSR2
uniprot id: H2NTP2
names: Subcellular Location Annotation
messages: Membrane

9601:FAM163A
gene id: 9601:FAM163A
uniprot id: H2N4I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9601:RBP5
gene id: 9601:RBP5
uniprot id: A0A2J8TBU0
uniprot id: Q5RBM7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Intracellular transport of retinol.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASB11
gene id: 9601:ASB11
uniprot id: A0A2J8W4E8
uniprot id: A0A2J8W4F4
uniprot id: A0A2J8W4F6
uniprot id: Q5RFS1
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRIM5
gene id: 9601:TRIM5
uniprot id: Q5C8T8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation (By similarity).
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
messages: Cytoplasm
messages: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
messages: Nucleus
messages: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity. The coiled coil domain is important for higher order multimerization by promoting the initial dimerization.
messages: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (By similarity).
messages: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.

9601:PCP4L1
gene id: 9601:PCP4L1
uniprot id: A0A2J8VHZ7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ABHD5
gene id: 9601:ABHD5
uniprot id: A0A2J8WXJ3
uniprot id: Q5RBI4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase activity is inhibited by detergents such as Triton X-100 and 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Acyltransferase activity is inhibited by the presence of magnesium and calcium.
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity).
messages: Cytoplasm
messages: Interacts with ADRP, PLIN and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2 (By similarity).
messages: Lipid droplet
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DUSP13
gene id: 9601:DUSP13
uniprot id: A0A2J8U5E8
uniprot id: H2NAH9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP6V0D2
gene id: 9601:ATP6V0D2
uniprot id: Q5R7B7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.

9601:DXO
gene id: 9601:DXO
uniprot id: A0A6D2X031
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9601:AHSA1
gene id: 9601:AHSA1
uniprot id: Q5R860
names: Similarity
messages: Belongs to the AHA1 family.

9601:HOXA7
gene id: 9601:HOXA7
uniprot id: H2PMK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9601:SMPX
gene id: 9601:SMPX
uniprot id: A0A140TAX5
uniprot id: Q5RB90
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9601:EXOSC8
gene id: 9601:EXOSC8
uniprot id: A0A2J8R637
uniprot id: A0A6D2VXF0
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TM9SF3
gene id: 9601:TM9SF3
uniprot id: H2NB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9601:CRIP2
gene id: 9601:CRIP2
uniprot id: Q5R7Y1
names: Subunit
messages: Interacts with TGFB1I1.

9601:STRBP
gene id: 9601:STRBP
uniprot id: Q5R6Y5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
messages: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).

9601:NDUFB10
gene id: 9601:NDUFB10
uniprot id: A0A2J8R9D4
uniprot id: P0CC01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with CHCHD4.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KLHDC7A
gene id: 9601:KLHDC7A
uniprot id: Q5R866
names: Subcellular Location Annotation
messages: Membrane

9601:DKFZP469M1914
gene id: 9601:DKFZP469M1914
uniprot id: Q5R5P6
names: Similarity
messages: Belongs to the MHC class I family.

9601:SMNDC1
gene id: 9601:SMNDC1
uniprot id: A0A2J8W7A0
uniprot id: Q5R591
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with spliceosomes. Associates with U4/U5/U6 tri-snRNP and with U2 snRNP (By similarity).
messages: Belongs to the SMN family.
messages: Cajal body
messages: Involved in spliceosome assembly (By similarity).
messages: Nucleus speckle
messages: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PARP16
gene id: 9601:PARP16
uniprot id: H2NNI5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9601:PDCD5
gene id: 9601:PDCD5
uniprot id: A0A2J8RL71
uniprot id: Q5RBT0
names: Caution
names: Function
names: Similarity
messages: Belongs to the PDCD5 family.
messages: May function in the process of apoptosis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDIP1
gene id: 9601:CDIP1
uniprot id: A0A6D2WND8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9601:STARD6
gene id: 9601:STARD6
uniprot id: A0A6D2VS94
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9601:C11H11orf54
gene id: 9601:C11H11orf54
uniprot id: A0A2J8XWH5
uniprot id: A0A6D2X1C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9601:INTS11
gene id: 9601:INTS11
uniprot id: Q5NVE6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
messages: Cytoplasm
messages: Nucleus
messages: The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.

9601:ARHGEF9
gene id: 9601:ARHGEF9
uniprot id: Q5RDK0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity).
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9601:CLRN1
gene id: 9601:CLRN1
uniprot id: A0A2J8WT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9601:TTC39C
gene id: 9601:TTC39C
uniprot id: H2NW20
names: Similarity
messages: Belongs to the TTC39 family.

9601:SSRP1
gene id: 9601:SSRP1
uniprot id: H2NDG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9601:VAT1L
gene id: 9601:VAT1L
uniprot id: Q5R480
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9601:SAP18
gene id: 9601:SAP18
uniprot id: A0A2J8RJK1
uniprot id: Q5RDT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAP18 family.
messages: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity).
messages: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
messages: Cytoplasm
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. For the ASAP complex, the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Forms a complex with SIN3A and HDAC1. Interacts with SUFU (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:G0S2
gene id: 9601:G0S2
uniprot id: H2N3U1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9601:LCE1C
gene id: 9601:LCE1C
uniprot id: A0A2J8VFF9
names: Similarity
messages: Belongs to the LCE family.

9601:PIGC
gene id: 9601:PIGC
uniprot id: A0A6D2VZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9601:IFNE
gene id: 9601:IFNE
uniprot id: A0A7R8C3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:LOC100440493
gene id: 9601:LOC100440493
uniprot id: H2NJ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:ERLIN2
gene id: 9601:ERLIN2
uniprot id: A0A2J8TPB0
uniprot id: A0A2J8TPC1
uniprot id: Q5R7C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex. Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139. Interacts with TMEM259 (By similarity). Interacts with TMEM41B (By similarity).
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACADSB
gene id: 9601:ACADSB
uniprot id: Q5RF40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (By similarity). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of the valproic acid drug (By similarity).

9601:GCNT3
gene id: 9601:GCNT3
uniprot id: A0A6D2XLZ9
names: Caution
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRRAP
gene id: 9601:TRRAP
uniprot id: A0A6D2VYZ8
uniprot id: K7EVE5
names: Caution
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GALNT16
gene id: 9601:GALNT16
uniprot id: A0A2J8T4T5
uniprot id: A0A6D2XB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9601:ARL1
gene id: 9601:ARL1
uniprot id: H2NIE2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9601:CLK4
gene id: 9601:CLK4
uniprot id: H2PHK0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:PRPH
gene id: 9601:PRPH
uniprot id: H2NH69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9601:PTMA
gene id: 9601:PTMA
uniprot id: A0A2J8TQB4
uniprot id: Q5R790
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pro/parathymosin family.
messages: Covalently linked to a small RNA of about 20 nucleotides.
messages: Interacts with NUPR1; regulates apoptotic process.
messages: Nucleus
messages: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NARFL
gene id: 9601:NARFL
uniprot id: Q5RF36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NARF family.
messages: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity).
messages: External component of the CIA complex. In the CIA complex, interacts directly with CIAO1 and MMS19.

9601:ASZ1
gene id: 9601:ASZ1
uniprot id: Q2IBE3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9601:MLX
gene id: 9601:MLX
uniprot id: A0A2J8RF06
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MFRP
gene id: 9601:MFRP
uniprot id: H2NFK8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:WDFY2
gene id: 9601:WDFY2
uniprot id: H2NJY0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9601:TSPAN4
gene id: 9601:TSPAN4
uniprot id: H2NCC9
uniprot id: Q5RAP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Forms a complex with integrins.
messages: Membrane

9601:MAPKAP1
gene id: 9601:MAPKAP1
uniprot id: Q5RDV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIN1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2, NBN and SGK1. Interacts with CCDC28B (By similarity).
messages: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).

9601:PNPLA8
gene id: 9601:PNPLA8
uniprot id: A0A2J8TA02
uniprot id: A0A2J8TA08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ETFDH
gene id: 9601:ETFDH
uniprot id: Q5RDD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Belongs to the ETF-QO/FixC family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Mitochondrion inner membrane
messages: Monomer.

9601:LOC100461296
gene id: 9601:LOC100461296
uniprot id: A0A2J8VFG3
names: Caution
names: Similarity
messages: Belongs to the LCE family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DLL4
gene id: 9601:DLL4
uniprot id: K7EVI9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9601:LZTR1
gene id: 9601:LZTR1
uniprot id: Q5R4Q7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTR1 family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Homodimer. Component of the BCR(LZTR1) E3 ubiquitin ligase complex, at least composed of CUL3, LZTR1 and RBX1. Interacts with Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Interacts with RAF1. Interacts with SHOC2. Interacts with PPP1CB.
messages: Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome.
messages: Recycling endosome
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.

9601:FDFT1
gene id: 9601:FDFT1
uniprot id: A0A2J8X3G8
uniprot id: A0A2J8X3H0
uniprot id: A0A8I5TFJ2
uniprot id: Q5R6U3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
messages: Endoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TCL1B
gene id: 9601:TCL1B
uniprot id: A0A2J8TLE5
names: Caution
names: Similarity
messages: Belongs to the TCL1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PP2D1
gene id: 9601:PP2D1
uniprot id: A0A2J8U443
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM189B
gene id: 9601:FAM189B
uniprot id: A0A2J8VGC6
uniprot id: A0A2J8VGH3
names: Similarity
messages: Belongs to the ENTREP family.

9601:PPHLN1
gene id: 9601:PPHLN1
uniprot id: A0A2J8WCG1
uniprot id: A0A2J8WCI6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPP2CB
gene id: 9601:PPP2CB
uniprot id: H2PPZ8
names: Similarity
messages: Belongs to the PPP phosphatase family.

9601:CFB
gene id: 9601:CFB
uniprot id: H2PIL6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:ZBTB1
gene id: 9601:ZBTB1
uniprot id: A0A2J8WLT8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLRG1
gene id: 9601:PLRG1
uniprot id: H2PEK1
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9601:MARCH10
gene id: 9601:MARCH10
uniprot id: A0A2J8UZA2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRXN1
gene id: 9601:SRXN1
uniprot id: H2P1H4
names: Similarity
messages: Belongs to the sulfiredoxin family.

9601:TOE1
gene id: 9601:TOE1
uniprot id: Q5RAR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.
messages: Interacts with U1, U2, U4, U5 and U6 snRNAs.
messages: Nucleus speckle
messages: nucleolus

9601:NOP16
gene id: 9601:NOP16
uniprot id: H2PHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9601:YARS2
gene id: 9601:YARS2
uniprot id: H2NGY3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9601:PARD6A
gene id: 9601:PARD6A
uniprot id: H2NR86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9601:LARP7
gene id: 9601:LARP7
uniprot id: A0A2J8XQ21
uniprot id: A0A6D2WL30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9601:ARPC2
gene id: 9601:ARPC2
uniprot id: A0A2J8TTY2
uniprot id: Q5R5Z5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (By similarity). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity). Interacts with DNAI3; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (By similarity).
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: synaptosome

9601:PTGDR
gene id: 9601:PTGDR
uniprot id: A0A663DB52
uniprot id: H2NL89
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDKN3
gene id: 9601:CDKN3
uniprot id: A0A6D2XG95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9601:SLC7A7
gene id: 9601:SLC7A7
uniprot id: A0A6D2W937
uniprot id: Q5RFC6
names: Subcellular Location Annotation
messages: Membrane

9601:GABRB1
gene id: 9601:GABRB1
uniprot id: H2PD83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:RPS19BP1
gene id: 9601:RPS19BP1
uniprot id: H2P4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9601:MCHR2
gene id: 9601:MCHR2
uniprot id: A0A6D2VZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:COG6
gene id: 9601:COG6
uniprot id: A0A8I5TGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9601:NGEF
gene id: 9601:NGEF
uniprot id: A0A2J8TQ32
uniprot id: Q5RDX5
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
messages: Cytoplasm
messages: Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase.
messages: Membrane
messages: Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis (By similarity).
messages: The DH domain and the PH domain are both required to mediate interaction with EPHA4.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: growth cone

9601:TPH2
gene id: 9601:TPH2
uniprot id: H2NI28
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9601:ZNF239
gene id: 9601:ZNF239
uniprot id: Q5R8G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:SYNM
gene id: 9601:SYNM
uniprot id: H2NPA1
names: Similarity
messages: Belongs to the intermediate filament family.

9601:ABI3
gene id: 9601:ABI3
uniprot id: Q5REM4
names: Similarity
messages: Belongs to the ABI family.

9601:TACC2
gene id: 9601:TACC2
uniprot id: A0A2J8W6G0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome

9601:SLC38A4
gene id: 9601:SLC38A4
uniprot id: Q5RE87
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine.
messages: The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.
messages: There is a disagreement about sodium-independent transport of cationic amino acids, such as L-arginine and L-lysine (By similarity). While Hatanaka et al. shown that SLC38A4 may mediate sodium-independent transport of cationic amino acids, such as L-arginine and L-lysine (By similarity). Recent studies by Fairweather et al., using quantitative LC-MS analysis, shown any transport activity of cationic amino acids, such as L-arginine and L-lysine (By similarity).
messages: microvillus membrane

9601:FAM135A
gene id: 9601:FAM135A
uniprot id: A0A2J8XWU4
uniprot id: Q5RA75
names: Caution
names: Similarity
messages: Belongs to the FAM135 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCSER2
gene id: 9601:CCSER2
uniprot id: Q5RF37
names: Similarity
messages: Belongs to the CCSER family.

9601:HMCN1
gene id: 9601:HMCN1
uniprot id: H2N4D8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MOB3A
gene id: 9601:MOB3A
uniprot id: A0A6D2XCZ7
uniprot id: Q5R5Z0
names: Function
names: Similarity
messages: Belongs to the MOB1/phocein family.
messages: May regulate the activity of kinases.

9601:EDNRB
gene id: 9601:EDNRB
uniprot id: A0A6D2W0X1
uniprot id: K7EVR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRAP
gene id: 9601:MRAP
uniprot id: A0A2J8UKV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SMYD2
gene id: 9601:SMYD2
uniprot id: H2N3Q6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9601:AIMP2
gene id: 9601:AIMP2
uniprot id: A0A6D2W8M2
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9601:LOC100443946
gene id: 9601:LOC100443946
uniprot id: H2NU36
names: Similarity
messages: Belongs to the intermediate filament family.

9601:ESF1
gene id: 9601:ESF1
uniprot id: H2P123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9601:OTOP1
gene id: 9601:OTOP1
uniprot id: H2PCW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9601:KIF3C
gene id: 9601:KIF3C
uniprot id: Q5R706
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
messages: Heterodimer of KIF3A and KIF3C.
messages: Microtubule-based anterograde translocator for membranous organelles.
messages: cytoskeleton

9601:MAP7
gene id: 9601:MAP7
uniprot id: Q5R6P0
names: Similarity
messages: Belongs to the MAP7 family.

9601:STXBP3
gene id: 9601:STXBP3
uniprot id: H2N6K0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9601:GUK1
gene id: 9601:GUK1
uniprot id: A0A2J8U1U0
uniprot id: A0A2J8U1V0
uniprot id: A0A663D6M6
uniprot id: A0A8I5TW17
uniprot id: H2N3H2
names: Caution
names: Similarity
messages: Belongs to the guanylate kinase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NSUN2
gene id: 9601:NSUN2
uniprot id: A0A663DIG8
uniprot id: H2PF54
uniprot id: K7ETJ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular exosome

9601:ZNF444
gene id: 9601:ZNF444
uniprot id: A0A2J8R5E5
uniprot id: H2P099
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WNT5A
gene id: 9601:WNT5A
uniprot id: A0A2J8T110
uniprot id: A0A6D2WWV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:LDLRAD4
gene id: 9601:LDLRAD4
uniprot id: A0A2J8RSK1
uniprot id: A0A2J8RSK6
uniprot id: A0A2J8RSL7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TIMP4
gene id: 9601:TIMP4
uniprot id: A0A663DB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9601:DNAJC27
gene id: 9601:DNAJC27
uniprot id: Q5RDE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).
messages: Nucleus

9601:SHC1
gene id: 9601:SHC1
uniprot id: Q5R7W7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Interacts (via PID domain) with PEAK1 (when phosphorylated) (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).
messages: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 and FLT4 signaling and by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1. Tyrosine phosphorylated by activated PTK2B/PYK2. Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity).
messages: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).

9601:ELP3
gene id: 9601:ELP3
uniprot id: H2PPX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9601:RXFP4
gene id: 9601:RXFP4
uniprot id: H2N5F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:MTRF1L
gene id: 9601:MTRF1L
uniprot id: A0A663D7R4
uniprot id: H2PKN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9601:LOC100437187
gene id: 9601:LOC100437187
uniprot id: A0A6D2W4R2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HOXD10
gene id: 9601:HOXD10
uniprot id: Q5REX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9601:RAP1B
gene id: 9601:RAP1B
uniprot id: A0A2J8W0U2
uniprot id: Q5RDM6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
messages: Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:FOXP4
gene id: 9601:FOXP4
uniprot id: A0A2J8Y3Z9
uniprot id: A0A2J8Y400
uniprot id: A0A2J8Y444
uniprot id: A0A6D2WPU5
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATF2
gene id: 9601:ATF2
uniprot id: A0A2J8VR64
uniprot id: A0A6D2WGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA.
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').

9601:ADGRE3
gene id: 9601:ADGRE3
uniprot id: Q5R993
names: Subcellular Location Annotation
messages: Membrane

9601:C4H4orf48
gene id: 9601:C4H4orf48
uniprot id: A0A2J8SRW2
uniprot id: A0A2J8SRW7
names: Caution
names: Subcellular Location Annotation
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KLC1
gene id: 9601:KLC1
uniprot id: Q5R581
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Cytoplasmic vesicle
messages: It is uncertain whether Met-1 or Met-5 is the initiator.
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
messages: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with BORCS5. Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (By similarity).
messages: cytoskeleton
messages: growth cone

9601:LOC100437602
gene id: 9601:LOC100437602
uniprot id: H2NS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:MAP2K5
gene id: 9601:MAP2K5
uniprot id: H2NNK7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:BATF2
gene id: 9601:BATF2
uniprot id: A0A2J8TYY0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACTL7A
gene id: 9601:ACTL7A
uniprot id: A0A6D2WCT6
uniprot id: H2PSZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:HCST
gene id: 9601:HCST
uniprot id: H2NYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

9601:EXOC7
gene id: 9601:EXOC7
uniprot id: Q5R672
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9601:PEMT
gene id: 9601:PEMT
uniprot id: H2NSW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9601:MRPL52
gene id: 9601:MRPL52
uniprot id: A0A2J8TS34
uniprot id: A0A2J8TS74
uniprot id: H2NKQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADRA2B
gene id: 9601:ADRA2B
uniprot id: H2P540
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9601:RPS12
gene id: 9601:RPS12
uniprot id: H2PKD2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9601:DMRTC2
gene id: 9601:DMRTC2
uniprot id: H2NYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9601:SSTR2
gene id: 9601:SSTR2
uniprot id: H2NUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9601:VPS33A
gene id: 9601:VPS33A
uniprot id: H2NIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9601:FAM120B
gene id: 9601:FAM120B
uniprot id: H2PKX7
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9601:ARFGAP3
gene id: 9601:ARFGAP3
uniprot id: A0A2J8TWI4
uniprot id: Q5R787
names: Activity Regulation
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).
messages: Golgi apparatus membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NOSIP
gene id: 9601:NOSIP
uniprot id: A0A2J8U876
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AKTIP
gene id: 9601:AKTIP
uniprot id: A0A2J8VYD8
uniprot id: Q5RE48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A.
messages: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF599
gene id: 9601:ZNF599
uniprot id: K7ET06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SLCO6A1
gene id: 9601:SLCO6A1
uniprot id: A0A2J8XEY8
uniprot id: A0A6D2WBR5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:COX5B
gene id: 9601:COX5B
uniprot id: A0A2J8RJ77
uniprot id: Q5REG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GNB1
gene id: 9601:GNB1
uniprot id: Q5R5W8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

9601:MPV17L2
gene id: 9601:MPV17L2
uniprot id: H2NY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9601:GALK2
gene id: 9601:GALK2
uniprot id: A0A2J8VBE0
uniprot id: Q5R6J8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity).
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Monomer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTUS1
gene id: 9601:MTUS1
uniprot id: A0A2J8X410
uniprot id: Q5R9I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MTUS1 family.
messages: Cell membrane
messages: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).
messages: Golgi apparatus
messages: Homodimer. Interacts with AGTR2. Interacts with PTPN6. Associates with microtubules (By similarity).
messages: Mitochondrion
messages: Nucleus

9601:SETD7
gene id: 9601:SETD7
uniprot id: A0A663D9B2
uniprot id: H2PEC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9601:CUL7
gene id: 9601:CUL7
uniprot id: Q5RCJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. Interacts with CUL9; leading to inhibit CUL9 activity. Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53. Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53. Interacts with CUL1; the interactions seems to be mediated by FBXW8. Interacts with OBSL1 (By similarity). Interacts (as part of the 3M complex) with HDAC4 and HDAC5; it is negatively regulated by ANKRA2 (By similarity).
messages: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity).
messages: Cytoplasm
messages: Golgi apparatus
messages: centrosome
messages: perinuclear region

9601:HK1
gene id: 9601:HK1
uniprot id: Q5RC71
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).
messages: Hexokinase is an allosteric enzyme inhibited by its product D-glucose 6-phosphate. Hexokinase activity is inhibited by N-acetyl-D-glucosamine.
messages: Mitochondrion outer membrane
messages: Monomer (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with VDAC1. The HK1-VDAC1 complex interacts with ATF2 (By similarity). Interacts (via N-terminal spermatogenic cell-specific region) with PFKM (via C-terminus) (By similarity).
messages: The N- and C-terminal halves of this hexokinase contain a hexokinase domain. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single D-glucose and D-glucose 6-phosphate molecule.
messages: cytosol

9601:TAS2R9
gene id: 9601:TAS2R9
uniprot id: H2NGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:MTRR
gene id: 9601:MTRR
uniprot id: A0A2J8TM17
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNBP
gene id: 9601:CNBP
uniprot id: A0A2J8TVF8
uniprot id: Q5R5R5
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.
messages: Associates with the 40S ribosomal subunit, the 80S ribosome and with polysomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC25A26
gene id: 9601:SLC25A26
uniprot id: A0A2J8S568
uniprot id: A0A663D920
uniprot id: H2PAB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM162A
gene id: 9601:FAM162A
uniprot id: A0A2J8W248
uniprot id: Q5R504
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0389 family.
messages: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition.
messages: Membrane
messages: Mitochondrion membrane
messages: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SERPINB2
gene id: 9601:SERPINB2
uniprot id: H2NWI5
names: Similarity
messages: Belongs to the serpin family.

9601:EXOC6B
gene id: 9601:EXOC6B
uniprot id: Q5RDI8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9601:DYRK1B
gene id: 9601:DYRK1B
uniprot id: A0A2J8SDP2
uniprot id: A0A2J8SDQ2
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DAAM1
gene id: 9601:DAAM1
uniprot id: A0A2J8WLC1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:B9D2
gene id: 9601:B9D2
uniprot id: H2NYX6
names: Subcellular Location Annotation
messages: cilium basal body

9601:DNTTIP1
gene id: 9601:DNTTIP1
uniprot id: Q5R595
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
messages: Monomer and homodimer. A minor proportion may form homotrimers. Interacts with ZNF541. Interacts with the terminal deoxynucleotidyltransferase DNTT. Interacts with TRERF1. Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and MIDEAS; this complex assembles into a tetramer that contains four copies of each protein chain. Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2.
messages: Nucleus
messages: The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence.
messages: The N-terminal domain mediates dimerization.

9601:NOC3L
gene id: 9601:NOC3L
uniprot id: Q5R952
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: May be required for adipogenesis.
messages: Nucleus speckle
messages: nucleolus

9601:KIAA0391
gene id: 9601:KIAA0391
uniprot id: H2NL10
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9601:THG1L
gene id: 9601:THG1L
uniprot id: H2PH78
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9601:TLCD1
gene id: 9601:TLCD1
uniprot id: A0A2J8TMK3
uniprot id: H2NT49
names: Subcellular Location Annotation
messages: Membrane

9601:MFSD11
gene id: 9601:MFSD11
uniprot id: Q5RCQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Despite its name it is related to the unc-93 family and not to the major facilitator superfamily.
messages: Membrane

9601:CCKBR
gene id: 9601:CCKBR
uniprot id: Q5R8V5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9601:DHX58
gene id: 9601:DHX58
uniprot id: Q5RFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9601:ENSA
gene id: 9601:ENSA
uniprot id: A0A6D2WHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9601:PSAT1
gene id: 9601:PSAT1
uniprot id: H2PSG7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9601:FAM98A
gene id: 9601:FAM98A
uniprot id: Q5R679
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FAM98 family.
messages: Interacts (via N- and C-terminus) with DDX1. Interacts (via N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts with PLEKHM1 (via N- and C-terminus).
messages: Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.

9601:ACBD5
gene id: 9601:ACBD5
uniprot id: Q5R7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).
messages: Belongs to the ATG37 family.
messages: Peroxisome membrane

9601:AMIGO3
gene id: 9601:AMIGO3
uniprot id: H2PAR2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9601:MBOAT1
gene id: 9601:MBOAT1
uniprot id: H2PI14
names: Subcellular Location Annotation
messages: Membrane

9601:BTF3
gene id: 9601:BTF3
uniprot id: A0A2J8VTE6
uniprot id: A0A663DE31
uniprot id: K7EUK9
names: Caution
names: Similarity
messages: Belongs to the NAC-beta family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EPHA6
gene id: 9601:EPHA6
uniprot id: A0A2J8S9E0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POLR3D
gene id: 9601:POLR3D
uniprot id: A0A6D2Y6Q1
names: Subcellular Location Annotation
messages: Nucleus

9601:ZC3HAV1
gene id: 9601:ZC3HAV1
uniprot id: Q5RC00
names: Similarity
messages: Belongs to the ARTD/PARP family.

9601:TP53AIP1
gene id: 9601:TP53AIP1
uniprot id: A0A2J8WZI2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ERG
gene id: 9601:ERG
uniprot id: A0A2J8UAN9
uniprot id: H2P354
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TSSK2
gene id: 9601:TSSK2
uniprot id: A0A2J8RBG4
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HTR4
gene id: 9601:HTR4
uniprot id: A0A2J8X5V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9601:PDIA3
gene id: 9601:PDIA3
uniprot id: Q5RDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (By similarity). Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Association with calcitriol does not affect its enzymatic activity (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum lumen
messages: Melanosome
messages: Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with SERPINA2 and with the S and Z variants of SERPINA1. Interacts with ATP2A2 (By similarity).

9601:PARP2
gene id: 9601:PARP2
uniprot id: A0A2J8TT28
uniprot id: A0A663DC62
uniprot id: H2NKH3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BZW1
gene id: 9601:BZW1
uniprot id: Q5R7L4
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

9601:DDX50
gene id: 9601:DDX50
uniprot id: A0A2J8WRD2
uniprot id: A0A8I5TJF1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9601:RABGGTA
gene id: 9601:RABGGTA
uniprot id: Q5NVK5
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
messages: Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.
messages: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

9601:RING1
gene id: 9601:RING1
uniprot id: H2PL49
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

9601:FBXO17
gene id: 9601:FBXO17
uniprot id: H2NYQ9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9601:TAF1D
gene id: 9601:TAF1D
uniprot id: Q5RCX3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF (By similarity).
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
messages: Nucleus

9601:TBC1D31
gene id: 9601:TBC1D31
uniprot id: Q5RD21
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PJA2; the interaction is direct and recruits PJA2 to centrosomes. Interacts with OFD1; regulates its activity in cilium assembly. Interacts with PRKACA.
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body

9601:SCG3
gene id: 9601:SCG3
uniprot id: A0A2J8VBP1
uniprot id: Q5R6A5
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: secretory vesicle membrane

9601:RDH12
gene id: 9601:RDH12
uniprot id: A0A6D2W470
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:L3HYPDH
gene id: 9601:L3HYPDH
uniprot id: Q5RC28
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the proline racemase family.
messages: Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
messages: Homodimer.
messages: In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.

9601:POLR1C
gene id: 9601:POLR1C
uniprot id: A0A663D8U9
uniprot id: H2PJ60
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9601:TNFRSF21
gene id: 9601:TNFRSF21
uniprot id: H2PJ96
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:LOC100456800
gene id: 9601:LOC100456800
uniprot id: A0A2J8T7U5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADNP
gene id: 9601:ADNP
uniprot id: A0A6D2WGI4
names: Subcellular Location Annotation
messages: Nucleus

9601:TRAF1
gene id: 9601:TRAF1
uniprot id: Q5RAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9601:FAM83F
gene id: 9601:FAM83F
uniprot id: H2P4G6
names: Similarity
messages: Belongs to the FAM83 family.

9601:HNRNPLL
gene id: 9601:HNRNPLL
uniprot id: A0A2J8SWP8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COG2
gene id: 9601:COG2
uniprot id: H2N3F3
names: Similarity
messages: Belongs to the COG2 family.

9601:TRIM74
gene id: 9601:TRIM74
uniprot id: Q5R8U5
names: Similarity
messages: Belongs to the SCC3 family.

9601:PGAM2
gene id: 9601:PGAM2
uniprot id: H2PM89
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9601:STX7
gene id: 9601:STX7
uniprot id: Q5R602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Early endosome membrane
messages: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A (By similarity). Interacts with TPC1 (By similarity).
messages: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).

9601:FURIN
gene id: 9601:FURIN
uniprot id: A0A6D2XW14
names: Similarity
messages: Belongs to the peptidase S8 family.

9601:ZNHIT3
gene id: 9601:ZNHIT3
uniprot id: A0A6D2WZ13
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ELF3
gene id: 9601:ELF3
uniprot id: H2N465
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:NAA10
gene id: 9601:NAA10
uniprot id: A0A6D2X1S3
uniprot id: H2PX70
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9601:FTMT
gene id: 9601:FTMT
uniprot id: H2PGC8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9601:ECHDC2
gene id: 9601:ECHDC2
uniprot id: A0A2J8V8S2
uniprot id: H2N7D3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9601:PLA2G3
gene id: 9601:PLA2G3
uniprot id: H2P437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9601:DYNC1LI1
gene id: 9601:DYNC1LI1
uniprot id: H2PB91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9601:EGFL8
gene id: 9601:EGFL8
uniprot id: A0A8I5TWM3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:UROD
gene id: 9601:UROD
uniprot id: A0A8I5T940
uniprot id: Q5RDK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.
messages: Cytoplasm
messages: Homodimer.

9601:CNBD2
gene id: 9601:CNBD2
uniprot id: A0A6D2WRG5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEMA3A
gene id: 9601:SEMA3A
uniprot id: A0A6D2VYS6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:TMEM35A
gene id: 9601:TMEM35A
uniprot id: A0A6D2XYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

9601:PFAS
gene id: 9601:PFAS
uniprot id: Q5R4H7
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9601:RHO
gene id: 9601:RHO
uniprot id: H2P9D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9601:LEF1
gene id: 9601:LEF1
uniprot id: A0A2J8XQB3
uniprot id: A0A2J8XQD6
uniprot id: A0A2J8XQK7
uniprot id: H2PE30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ESX1
gene id: 9601:ESX1
uniprot id: H2PWD5
names: Subcellular Location Annotation
messages: Nucleus

9601:ZNF10
gene id: 9601:ZNF10
uniprot id: A0A8I5UA98
uniprot id: H2NJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:CASP3
gene id: 9601:CASP3
uniprot id: A0A6D2X1B2
names: Similarity
messages: Belongs to the peptidase C14A family.

9601:DIRAS2
gene id: 9601:DIRAS2
uniprot id: Q5R6S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Di-Ras family.
messages: Cell membrane
messages: Displays low GTPase activity and exists predominantly in the GTP-bound form.

9601:FABP2
gene id: 9601:FABP2
uniprot id: H2PE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9601:BRCC3
gene id: 9601:BRCC3
uniprot id: A0A2J8RM66
uniprot id: A0A2J8RM80
uniprot id: A0A6D2Y4A8
uniprot id: H2PXB8
uniprot id: Q5R9L6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin (By similarity). Interacts with PWWP2B (By similarity). Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B (By similarity).
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle pole

9601:SRGAP2
gene id: 9601:SRGAP2
uniprot id: A0A2J8V6V5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RSPH9
gene id: 9601:RSPH9
uniprot id: A0A663D9N8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HSPB2
gene id: 9601:HSPB2
uniprot id: H2NFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9601:RPL9
gene id: 9601:RPL9
uniprot id: Q5R9Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9601:USP18
gene id: 9601:USP18
uniprot id: Q5RE63
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.

9601:CRYAB
gene id: 9601:CRYAB
uniprot id: A0A2J8X208
uniprot id: Q5R9K0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).
messages: Lysosome
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
messages: Nucleus
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP2A1
gene id: 9601:ATP2A1
uniprot id: A0A2J8TJL4
uniprot id: A0A663DFZ0
uniprot id: H2NQI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100448122
gene id: 9601:LOC100448122
uniprot id: H2N611
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:NFE2L2
gene id: 9601:NFE2L2
uniprot id: A0A2J8VRB7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF706
gene id: 9601:ZNF706
uniprot id: A0A2J8UFJ1
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRMT5
gene id: 9601:PRMT5
uniprot id: Q5R698
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (By similarity). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation. Methylates H4R3 in genes involved…
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Forms, at least, homodimers and homotetramers. Component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A. Found in a complex composed of PRMT5, WDR77 and RIOK1. RIOK1 and CLNS1A associate with PRMT5 in a mutually exclusive fashion, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (By similarity). Interacts with PRDM1 (By similarity). Identified in a complex composed of methylosome and PRMT1 and ERH. Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 and CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1. Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln. Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10. Interacts with WDR77. Interacts with IWS1. Interacts with CRY1. Interacts with POLR2A. Interacts with SMN1/SMN2. Interacts with LYAR; this interaction is direct. Interacts with TTC5/STRAP; this interaction is DNA damage-dependent and promotes PRMT5 interaction with p53/TP53. Interacts with p53/TP53 in response to DNA damage; the interaction is TTC5/STRAP dependent. Interacts with FAM47E; the interaction is direct, promotes PRMT5 localization to chromatin, and does not disrupt its association with WDR77 or STUB1 (By similarity). Interacts with TDRD6 (By similarity). Interacts with STUB1 (By similarity).
messages: Golgi apparatus
messages: Nucleus

9601:TDRD7
gene id: 9601:TDRD7
uniprot id: Q5RAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity).
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).

9601:RTN4
gene id: 9601:RTN4
uniprot id: Q5R4X9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:DAP3
gene id: 9601:DAP3
uniprot id: Q5R8P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9601:CHST2
gene id: 9601:CHST2
uniprot id: H2PBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9601:GNGT1
gene id: 9601:GNGT1
uniprot id: A0A6D2WDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9601:TMBIM1
gene id: 9601:TMBIM1
uniprot id: Q5RF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9601:KRT82
gene id: 9601:KRT82
uniprot id: H2NHD4
names: Similarity
messages: Belongs to the intermediate filament family.

9601:AKR1C3
gene id: 9601:AKR1C3
uniprot id: Q5R7C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldo/keto reductase family.
messages: Cytoplasm
messages: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also displays retinaldehyde reductase activity toward 9-cis-retinal.

9601:BEX5
gene id: 9601:BEX5
uniprot id: A0A2J8U5Z2
uniprot id: A0A6D2XUG4
names: Caution
names: Similarity
messages: Belongs to the BEX family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSTA
gene id: 9601:CSTA
uniprot id: H2P9K4
names: Similarity
messages: Belongs to the cystatin family.

9601:GJD3
gene id: 9601:GJD3
uniprot id: H2NU78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:DOHH
gene id: 9601:DOHH
uniprot id: H2NWZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9601:HENMT1
gene id: 9601:HENMT1
uniprot id: A0A6D2VX04
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9601:TOMM20
gene id: 9601:TOMM20
uniprot id: Q5RA31
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom20 family.
messages: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1 (By similarity). Interacts with TBC1D21 (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9601:GPR107
gene id: 9601:GPR107
uniprot id: A0A2J8UJH4
uniprot id: H2PTN5
names: Subcellular Location Annotation
messages: Membrane

9601:ST3GAL6
gene id: 9601:ST3GAL6
uniprot id: A0A6D2W6H5
uniprot id: Q5RE85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi apparatus membrane
messages: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity).
messages: Membrane

9601:MKLN1
gene id: 9601:MKLN1
uniprot id: A0A2J8U471
uniprot id: Q5RB35
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity).
messages: Cytoplasm
messages: Homodimer; may form higher oligomers (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (By similarity). Interacts with RANBP9 (By similarity). Part of a complex consisting of RANBP9, MKLN1 and GID8 (By similarity). Interacts with GABRA1 (By similarity). Interacts with the C-terminal tail of PTGER3 (By similarity).
messages: Postsynapse
messages: Synapse
messages: The LisH mediates head to tail dimerization.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cell cortex
messages: cytosol
messages: nucleoplasm
messages: ruffle

9601:SCOC
gene id: 9601:SCOC
uniprot id: A0A6D2XSL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9601:OSTF1
gene id: 9601:OSTF1
uniprot id: A0A2J8SU95
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POLR2J
gene id: 9601:POLR2J
uniprot id: A0A8I5TMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9601:RIN2
gene id: 9601:RIN2
uniprot id: H2P151
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9601:LOC100451254
gene id: 9601:LOC100451254
uniprot id: A0A6D2X0W0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:APOM
gene id: 9601:APOM
uniprot id: A0A2J8R4P9
uniprot id: Q5R894
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAS2R13
gene id: 9601:TAS2R13
uniprot id: H2NGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:HMOX1
gene id: 9601:HMOX1
uniprot id: H2P472
uniprot id: Q5R7E3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A soluble form arises by proteolytic removal of the membrane anchor.
messages: Belongs to the heme oxygenase family.
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (By similarity). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
messages: Endoplasmic reticulum membrane

9601:LOC100433891
gene id: 9601:LOC100433891
uniprot id: H2PI89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:ALG3
gene id: 9601:ALG3
uniprot id: H2PC64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:DCLK1
gene id: 9601:DCLK1
uniprot id: A0A2J8UTL0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:GBP1
gene id: 9601:GBP1
uniprot id: Q5RBE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures (By similarity). Interacts with SQSTM1 (By similarity).
messages: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Promotes IFN-gamma-mediated host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitylated proteins to autolysosomes for the generation of bacteriolytic peptides (By similarity). Exhibits antiviral activity against influenza virus (By similarity).
messages: Isoprenylation is required for proper subcellular location (By similarity).
messages: Secreted

9601:CCR8
gene id: 9601:CCR8
uniprot id: A0A663DE85
names: Caution
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPS6KA3
gene id: 9601:RPS6KA3
uniprot id: A0A663D5M5
uniprot id: H2PV35
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9601:DDX53
gene id: 9601:DDX53
uniprot id: H2PV43
names: Similarity
messages: Belongs to the DEAD box helicase family.

9601:CEP68
gene id: 9601:CEP68
uniprot id: Q5RCQ2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CNTLN; the interaction recruits CEP68 to the centrosome. Interacts with the SCF(FBXW11) complex which contains SKP1, CUL1 and FBXW11; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT. Also interacts with F-box protein BTRC. Interacts with serine/threonine-protein kinase PLK1; the interaction leads to phosphorylation of CEP68 and its subsequent degradation. Interacts with NEK2; the interaction leads to phosphorylation of CEP68.
messages: Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.
messages: Phosphorylation by PLK1 is required for binding to BTRC in prometaphase. Phosphorylated directly or indirectly by NEK2. NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis.
messages: Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes. Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation.
messages: centrosome

9601:MTMR9
gene id: 9601:MTMR9
uniprot id: H2PPJ9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9601:CILP2
gene id: 9601:CILP2
uniprot id: A0A2J8T5E2
uniprot id: H2NY69
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:RDM1
gene id: 9601:RDM1
uniprot id: A0A2J8RCM0
uniprot id: H2NTE6
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9601:GJD4
gene id: 9601:GJD4
uniprot id: H2NA61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:LOC100444316
gene id: 9601:LOC100444316
uniprot id: H2NUE0
names: Similarity
messages: Belongs to the TACO1 family.

9601:PDK2
gene id: 9601:PDK2
uniprot id: Q5NVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9601:MYL1
gene id: 9601:MYL1
uniprot id: A0A2J8XSW9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP5PB
gene id: 9601:ATP5PB
uniprot id: Q5RFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9601:COMMD2
gene id: 9601:COMMD2
uniprot id: A0A2J8WST7
uniprot id: Q5R610
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
messages: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:METTL2A
gene id: 9601:METTL2A
uniprot id: H2NVP5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9601:STK40
gene id: 9601:STK40
uniprot id: Q5R667
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9601:CPOX
gene id: 9601:CPOX
uniprot id: H2P9X7
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9601:ZNF660
gene id: 9601:ZNF660
uniprot id: A0A2J8WXJ5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TBXAS1
gene id: 9601:TBXAS1
uniprot id: A0A2J8V3D1
uniprot id: A0A6D2X3L5
uniprot id: Q5R7A6
names: Caution
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC6A5
gene id: 9601:SLC6A5
uniprot id: H2NDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9601:RHCE
gene id: 9601:RHCE
uniprot id: A0A2J8SIR0
uniprot id: A0A2J8SIR1
uniprot id: A0A2J8SIR4
uniprot id: A0A2J8SIR6
uniprot id: A0A8I5U2A9
uniprot id: A0A8I5UH48
uniprot id: H2N8I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BRICD5
gene id: 9601:BRICD5
uniprot id: A0A2J8S8C9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITGB8
gene id: 9601:ITGB8
uniprot id: H2PMQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9601:ERLIN1
gene id: 9601:ERLIN1
uniprot id: A0A2J8XY73
uniprot id: Q5RCJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a heteromeric complex with ERLIN2. In complex with ERLIN2, interacts with RNF170. Interacts with AMFR and SYVN1 (By similarity).
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MED25
gene id: 9601:MED25
uniprot id: A0A2J8U8G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 25 family.
messages: Nucleus

9601:ZNF684
gene id: 9601:ZNF684
uniprot id: H2N7T9
uniprot id: Q5RCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:KHDC1L
gene id: 9601:KHDC1L
uniprot id: A0A2J8RYT0
names: Similarity
messages: Belongs to the KHDC1 family.

9601:HIBCH
gene id: 9601:HIBCH
uniprot id: Q5RAR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9601:SLC16A3
gene id: 9601:SLC16A3
uniprot id: Q5RDA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9601:AGXT
gene id: 9601:AGXT
uniprot id: Q5RDP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification. Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism.
messages: Peroxisome
messages: The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal.

9601:AKIRIN1
gene id: 9601:AKIRIN1
uniprot id: H2N7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9601:NEMP2
gene id: 9601:NEMP2
uniprot id: H2P851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9601:DEF8
gene id: 9601:DEF8
uniprot id: A0A2J8RUX9
uniprot id: A0A2J8RUY5
uniprot id: A0A2J8RUY8
uniprot id: A0A8I5TR04
names: Similarity
messages: Belongs to the DEF8 family.

9601:PCNX4
gene id: 9601:PCNX4
uniprot id: Q5REU8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:GSK3A
gene id: 9601:GSK3A
uniprot id: A0A6D2VTU7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9601:ABHD16A
gene id: 9601:ABHD16A
uniprot id: Q5R6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane
messages: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity).

9601:FGD3
gene id: 9601:FGD3
uniprot id: Q5R5T1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).
messages: cytoskeleton

9601:LOC100450459
gene id: 9601:LOC100450459
uniprot id: H2P3L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9601:FOXN1
gene id: 9601:FOXN1
uniprot id: A0A6D2XSJ7
names: Subcellular Location Annotation
messages: Nucleus

9601:SPSB3
gene id: 9601:SPSB3
uniprot id: A0A6D2XNJ2
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9601:TCTEX1D4
gene id: 9601:TCTEX1D4
uniprot id: H2N7M0
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9601:CA7
gene id: 9601:CA7
uniprot id: A0A2J8VUD3
uniprot id: H2NR48
names: Caution
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DR1
gene id: 9601:DR1
uniprot id: A0A6D2WHJ8
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9601:NELL2
gene id: 9601:NELL2
uniprot id: Q5R3Z7
names: Subcellular Location Annotation
names: Subunit
messages: Homotrimer. Binds to PKC beta-1 (By similarity).
messages: Secreted

9601:CLCN3
gene id: 9601:CLCN3
uniprot id: A0A2J8VZR3
uniprot id: A0A663DIL1
uniprot id: H2PEQ8
uniprot id: Q5RDJ7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Monomer and homodimer (By similarity). Forms heterodimers with CLCN4 (By similarity).
messages: N-glycosylated.
messages: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PYCR2
gene id: 9601:PYCR2
uniprot id: Q5RAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Cytoplasm
messages: Homodecamer; composed of 5 homodimers. Interacts with LTO1.
messages: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).
messages: Mitochondrion

9601:CPLX2
gene id: 9601:CPLX2
uniprot id: A0A6D2WLM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9601:TMEM135
gene id: 9601:TMEM135
uniprot id: A0A6D2WVS7
uniprot id: H2NEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9601:ZNF879
gene id: 9601:ZNF879
uniprot id: K7EVS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:TBCA
gene id: 9601:TBCA
uniprot id: A0A2J8VT22
uniprot id: A0A6D2XP30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9601:DAB1
gene id: 9601:DAB1
uniprot id: A0A6D2YCS9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HAMP
gene id: 9601:HAMP
uniprot id: Q5NVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hepcidin family.
messages: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
messages: Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
messages: Secreted

9601:SELENOW
gene id: 9601:SELENOW
uniprot id: Q5NVB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

9601:SLC9B2
gene id: 9601:SLC9B2
uniprot id: Q5R6B8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Inhibited by phloretin but not the classical SLC9A-inhibitor amiloride.
messages: Mitochondrion membrane
messages: Na+/H+ antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, Na(+) content and organellar volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).
messages: flagellum membrane
messages: synaptic vesicle membrane

9601:LOC100435005
gene id: 9601:LOC100435005
uniprot id: A0A8I5UEM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9601:CXCL9
gene id: 9601:CXCL9
uniprot id: H2PDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:KLHL9
gene id: 9601:KLHL9
uniprot id: A0A6D2W7I4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RP2
gene id: 9601:RP2
uniprot id: H2PVE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9601:DCBLD1
gene id: 9601:DCBLD1
uniprot id: H2PK65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:PRPF18
gene id: 9601:PRPF18
uniprot id: Q5RE03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP18 family.
messages: Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs (By similarity).
messages: Nucleus speckle
messages: Participates in the second step of pre-mRNA splicing.

9601:ZNF585A
gene id: 9601:ZNF585A
uniprot id: Q5RDX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:UTS2
gene id: 9601:UTS2
uniprot id: H2N993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9601:LOC100432049
gene id: 9601:LOC100432049
uniprot id: A0A6D2W1K6
uniprot id: H2NGD6
names: Subcellular Location Annotation
messages: Nucleus

9601:AATF
gene id: 9601:AATF
uniprot id: H2NTG3
names: Similarity
messages: Belongs to the AATF family.

9601:CDK18
gene id: 9601:CDK18
uniprot id: A0A140TAW4
uniprot id: Q5RD01
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: May play a role in signal transduction cascades in terminally differentiated cells.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C10H10orf53
gene id: 9601:C10H10orf53
uniprot id: A0A6D2Y3S0
names: Similarity
messages: Belongs to the UPF0728 family.

9601:ZZZ3
gene id: 9601:ZZZ3
uniprot id: H2N700
names: Subcellular Location Annotation
messages: Nucleus

9601:GALT
gene id: 9601:GALT
uniprot id: H2PRV8
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9601:SMARCD1
gene id: 9601:SMARCD1
uniprot id: H2NH93
names: Similarity
messages: Belongs to the SMARCD family.

9601:KRT35
gene id: 9601:KRT35
uniprot id: H2NU34
names: Similarity
messages: Belongs to the intermediate filament family.

9601:HAUS1
gene id: 9601:HAUS1
uniprot id: H2NW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9601:RAB27B
gene id: 9601:RAB27B
uniprot id: H2NWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9601:SUMF1
gene id: 9601:SUMF1
uniprot id: A0A663DCE5
uniprot id: H2PA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9601:TUBAL3
gene id: 9601:TUBAL3
uniprot id: H2N9N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9601:RSPH1
gene id: 9601:RSPH1
uniprot id: A0A6D2XDB4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC30A9
gene id: 9601:SLC30A9
uniprot id: Q5R4H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a zinc transporter involved in intracellular zinc homeostasis. Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes.
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Interacts with GRIP1, ESR1, AR and CTNNB1.
messages: Membrane
messages: Nucleus

9601:ZFAND3
gene id: 9601:ZFAND3
uniprot id: A0A6D2WKS5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:REM2
gene id: 9601:REM2
uniprot id: A0A6D2XKA3
names: Subcellular Location Annotation
messages: Cell membrane

9601:DPRX
gene id: 9601:DPRX
uniprot id: H2P009
names: Subcellular Location Annotation
messages: Nucleus

9601:POLA1
gene id: 9601:POLA1
uniprot id: A0A2J8W3W0
uniprot id: H2PV58
names: Caution
names: Similarity
messages: Belongs to the DNA polymerase type-B family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100453847
gene id: 9601:LOC100453847
uniprot id: H2NEH3
names: Subcellular Location Annotation
messages: Membrane

9601:GPR180
gene id: 9601:GPR180
uniprot id: H2NK53
names: Subcellular Location Annotation
messages: Membrane

9601:GNG2
gene id: 9601:GNG2
uniprot id: A0A2J8WKN5
uniprot id: Q5R7U4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). In this context, interacts with GNB2 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity).
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITGA1
gene id: 9601:ITGA1
uniprot id: H2PFI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9601:BHLHB9
gene id: 9601:BHLHB9
uniprot id: A0A6D2Y8D0
names: Similarity
messages: Belongs to the GPRASP family.

9601:MAGOHB
gene id: 9601:MAGOHB
uniprot id: H2NGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9601:MTM1
gene id: 9601:MTM1
uniprot id: Q5R9S3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by phosphatidylinositol 5-phosphate (PI5P).
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.
messages: Late endosome
messages: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
messages: The GRAM domain mediates binding to PI(3,5)P2 and, with lower affinity, to other phosphoinositides.
messages: filopodium
messages: ruffle
messages: sarcomere

9601:L3MBTL2
gene id: 9601:L3MBTL2
uniprot id: Q5R737
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity).

9601:MAN1A2
gene id: 9601:MAN1A2
uniprot id: A0A663DA66
uniprot id: H2N674
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PON1
gene id: 9601:PON1
uniprot id: H2PMW2
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9601:LOC100443915
gene id: 9601:LOC100443915
uniprot id: H2NHV2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:MAPKAPK2
gene id: 9601:MAPKAPK2
uniprot id: A0A663D5Q8
uniprot id: H2N3X6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:SPATA18
gene id: 9601:SPATA18
uniprot id: A0A2J8SGI3
uniprot id: H2PDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9601:SUPT4H1
gene id: 9601:SUPT4H1
uniprot id: Q5RFH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).
messages: Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1 (By similarity).
messages: Nucleus

9601:MNAT1
gene id: 9601:MNAT1
uniprot id: H2NLF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9601:ANXA3
gene id: 9601:ANXA3
uniprot id: H2PDQ4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9601:CMBL
gene id: 9601:CMBL
uniprot id: A0A2J8SHI6
uniprot id: Q5RBU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: Cysteine hydrolase.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:ZFP30
gene id: 9601:ZFP30
uniprot id: A0A2J8REC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF284
gene id: 9601:ZNF284
uniprot id: A0A2J8RTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:CIP2A
gene id: 9601:CIP2A
uniprot id: A0A2J8W338
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRPT1
gene id: 9601:TRPT1
uniprot id: A0A2J8TYF7
uniprot id: A0A6D2VXR5
uniprot id: H2ND08
names: Caution
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EYS
gene id: 9601:EYS
uniprot id: H2PJI1
uniprot id: Q5R6R1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EYS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required to maintain the integrity of photoreceptor cells (By similarity). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity).
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: interphotoreceptor matrix
messages: photoreceptor outer segment

9601:PSMC2
gene id: 9601:PSMC2
uniprot id: A0A6D2XZZ0
uniprot id: Q5R8D7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Monoubiquitinated by RNF181.
messages: Nucleus

9601:GABRA1
gene id: 9601:GABRA1
uniprot id: A0A2J8X718
uniprot id: A0A6D2WD68
uniprot id: Q5R401
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:FGF13
gene id: 9601:FGF13
uniprot id: A0A2J8WXA0
uniprot id: A0A2J8WXC0
uniprot id: Q5RDS9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Interacts with SCN8A; regulates SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity.
messages: May be phosphorylated.
messages: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).
messages: Nucleus
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9601:LOC100460095
gene id: 9601:LOC100460095
uniprot id: A0A6D2X432
uniprot id: H2NQZ1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9601:RECQL4
gene id: 9601:RECQL4
uniprot id: H2PRI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9601:AP4S1
gene id: 9601:AP4S1
uniprot id: H2NKZ0
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9601:ACADM
gene id: 9601:ACADM
uniprot id: H2N709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9601:LDHAL6B
gene id: 9601:LDHAL6B
uniprot id: H2NND7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9601:TRIM2
gene id: 9601:TRIM2
uniprot id: A0A663DAG1
uniprot id: H2PEJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRPV2
gene id: 9601:TRPV2
uniprot id: H2NSV0
names: Subcellular Location Annotation
messages: Membrane

9601:TAP2
gene id: 9601:TAP2
uniprot id: A0A6D2XPX1
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9601:C10H10orf126
gene id: 9601:C10H10orf126
uniprot id: A0A6D2XSM6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MMP21
gene id: 9601:MMP21
uniprot id: H2NBY2
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:ETFRF1
gene id: 9601:ETFRF1
uniprot id: H2NGU0
names: Similarity
messages: Belongs to the complex I LYR family.

9601:ABRACL
gene id: 9601:ABRACL
uniprot id: A0A2J8X9R8
names: Caution
names: Similarity
messages: Belongs to the costars family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PDGFRB
gene id: 9601:PDGFRB
uniprot id: H2PH25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9601:EPHX1
gene id: 9601:EPHX1
uniprot id: Q5R5E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:PSMD2
gene id: 9601:PSMD2
uniprot id: A0A2J8WHA1
uniprot id: Q5R9I6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (By similarity). Interacts with RPGRIP1L (By similarity). Interacts with CRY1 in a KDM8-dependent manner (By similarity).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WT1
gene id: 9601:WT1
uniprot id: A0A2J8WGC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9601:ATRAID
gene id: 9601:ATRAID
uniprot id: A0A2J8VMX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALAS1
gene id: 9601:ALAS1
uniprot id: Q5R9R9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
messages: Homodimer (By similarity). Interacts (hydroxylated form) with VHL (By similarity).
messages: In normoxia, is hydroxylated at Pro-576, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome.
messages: Mitochondrion inner membrane
messages: Ubiquitinated; in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome.

9601:ATP5PO
gene id: 9601:ATP5PO
uniprot id: Q5RD23
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity).
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

9601:MC4R
gene id: 9601:MC4R
uniprot id: H2NWG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9601:PPID
gene id: 9601:PPID
uniprot id: A0A6D2XJC2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAF2
gene id: 9601:TAF2
uniprot id: K7ETV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9601:NFYC
gene id: 9601:NFYC
uniprot id: A0A2J8Y625
uniprot id: Q5RA23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYC/HAP5 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MANBAL
gene id: 9601:MANBAL
uniprot id: A0A6D2XLE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IRX2
gene id: 9601:IRX2
uniprot id: A0A6D2WD05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9601:TMEM141
gene id: 9601:TMEM141
uniprot id: A0A2J8RMR2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WNT16
gene id: 9601:WNT16
uniprot id: H2PNB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9601:COLCA2
gene id: 9601:COLCA2
uniprot id: A0A2J8X239
uniprot id: A0A2J8X253
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DERL2
gene id: 9601:DERL2
uniprot id: A0A2J8R7S8
uniprot id: Q5RC74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1. Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes. Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins. Interacts with OS9. Interacts with SELENOK and SELENOS. Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control. Interacts with CCDC47 (By similarity).
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGGY
gene id: 9601:FGGY
uniprot id: H2N784
names: Similarity
messages: Belongs to the FGGY kinase family.

9601:PLSCR3
gene id: 9601:PLSCR3
uniprot id: A0A6D2XCC1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9601:GPRIN1
gene id: 9601:GPRIN1
uniprot id: H2PHG6
names: Function
messages: May be involved in neurite outgrowth.

9601:OPTN
gene id: 9601:OPTN
uniprot id: Q5R923
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
messages: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
messages: Recycling endosome
messages: Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9601:IFNLR1
gene id: 9601:IFNLR1
uniprot id: A0A2J8SIW7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EHD1
gene id: 9601:EHD1
uniprot id: A0A2J8TYX8
uniprot id: Q5RBP4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization. Interacts (via EH domain) with MICALL1 (via NPF1 motif); the interaction is direct and recruits EHD1 to membranes. Interacts with RAB35; the interaction is indirect through MICALL1 and recruits EHD1 to membranes. Interacts (via EH domain) with PACSIN2 (via NPF motifs); regulates localization to tubular recycling endosome membranes. Interacts with PACSIN1. Interacts with RAB8A. Interacts with FER1L5 (via second C2 domain). Interacts with MYOF. Interacts with ZFYVE20. Interacts (via EH domain) with RAB11FIP2.
messages: Membrane
messages: Recycling endosome membrane
messages: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cilium membrane

9601:ZMYM2
gene id: 9601:ZMYM2
uniprot id: Q5RDJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZNF198, ZNF217, ZMYM3, GSE1 and GTF2I.
messages: May function as a transcription factor.
messages: Nucleus

9601:COL4A3BP
gene id: 9601:COL4A3BP
uniprot id: Q5R6M6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA. Interacts (via FFAT motif) with the MOSPD2 (via MSP domain).
messages: Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
messages: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.
messages: The FFAT motif is required for interaction with VAPA, VAPB and MOSPD2.
messages: The PH domain targets the Golgi apparatus.
messages: The START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids.

9601:TRAM1
gene id: 9601:TRAM1
uniprot id: Q5R7Z3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SEC61B. May interact with Derlin-1/DERL1.
messages: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: N-glycosylated.

9601:NDUFA13
gene id: 9601:NDUFA13
uniprot id: H2NY66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9601:EBF1
gene id: 9601:EBF1
uniprot id: H2PH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9601:ADPRHL1
gene id: 9601:ADPRHL1
uniprot id: Q5RCJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the ADP-ribosylglycohydrolase family, lacks the metal-binding and substrate-binding residues, suggesting that it has no hydrolase activity.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
messages: sarcomere

9601:FAM104B
gene id: 9601:FAM104B
uniprot id: A0A2J8R424
uniprot id: A0A2J8R438
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAF9B
gene id: 9601:TAF9B
uniprot id: A0A2J8USY6
uniprot id: Q5R7P7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription (By similarity).
messages: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL41
gene id: 9601:RPL41
uniprot id: Q5RFG9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

9601:FXYD1
gene id: 9601:FXYD1
uniprot id: A0A6D2Y9A6
names: Similarity
messages: Belongs to the FXYD family.

9601:PARK7
gene id: 9601:PARK7
uniprot id: A0A8I5THI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9601:TACC1
gene id: 9601:TACC1
uniprot id: A0A2J8TP23
uniprot id: A0A2J8TP47
uniprot id: A0A2J8TP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9601:ZNF197
gene id: 9601:ZNF197
uniprot id: A0A2J8WXG9
uniprot id: A0A6D2XB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SSPN
gene id: 9601:SSPN
uniprot id: A0A2J8WBK9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTMR7
gene id: 9601:MTMR7
uniprot id: Q5R6F6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Heterodimer (via C-terminus) with MTMR9 (via coiled coil domain); the interaction enhances MTMR7 catalytic activity (By similarity). Does not homodimerize (By similarity). Interacts with RAB1B (in GDP-bound form) (By similarity).
messages: Interaction with MTMR9 increases phosphatase activity.
messages: Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).

9601:GSG1
gene id: 9601:GSG1
uniprot id: A0A2J8SQW2
uniprot id: A0A2J8SQW6
uniprot id: A0A2J8SQW8
uniprot id: A0A2J8SQX2
uniprot id: A0A2J8SQX9
uniprot id: H2NGN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP6V1D
gene id: 9601:ATP6V1D
uniprot id: A0A2J8WM26
uniprot id: Q5RCS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Membrane
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with SNX10 (By similarity).
messages: centrosome
messages: cilium
messages: clathrin-coated vesicle membrane

9601:POLM
gene id: 9601:POLM
uniprot id: A0A663DGK1
uniprot id: H2PM88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9601:C21H21orf62
gene id: 9601:C21H21orf62
uniprot id: A0A2J8UKZ5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KLF11
gene id: 9601:KLF11
uniprot id: A0A2J8V3Z5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100456072
gene id: 9601:LOC100456072
uniprot id: A0A2J8VFI8
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9601:NKIRAS1
gene id: 9601:NKIRAS1
uniprot id: A0A6D2XCK5
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9601:SNU13
gene id: 9601:SNU13
uniprot id: A0A6D2WUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9601:ELMOD1
gene id: 9601:ELMOD1
uniprot id: Q5NVD7
names: Function
messages: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.

9601:GINS2
gene id: 9601:GINS2
uniprot id: A0A6D2WUC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9601:TRMT1
gene id: 9601:TRMT1
uniprot id: A0A6D2W0T7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9601:SUN3
gene id: 9601:SUN3
uniprot id: A0A6D2X6H4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SAMM50
gene id: 9601:SAMM50
uniprot id: H2P4P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9601:NAP1L5
gene id: 9601:NAP1L5
uniprot id: Q5R4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Nucleus

9601:LOC100434861
gene id: 9601:LOC100434861
uniprot id: H2NYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:CSTB
gene id: 9601:CSTB
uniprot id: A0A6D2WJP0
names: Similarity
messages: Belongs to the cystatin family.

9601:MSMP
gene id: 9601:MSMP
uniprot id: H2PRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9601:BEAN1
gene id: 9601:BEAN1
uniprot id: A0A2J8VU77
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPTAN1
gene id: 9601:SPTAN1
uniprot id: A0A2J8UJU0
uniprot id: A0A2J8UJU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cell cortex
messages: cytoskeleton

9601:MRPL14
gene id: 9601:MRPL14
uniprot id: H2PJ66
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9601:PEPD
gene id: 9601:PEPD
uniprot id: Q5RFB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer.
messages: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen (By similarity).

9601:ICOS
gene id: 9601:ICOS
uniprot id: H2P8D4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9601:PSEN2
gene id: 9601:PSEN2
uniprot id: A0A2J8U220
uniprot id: A0A6D2YCE0
uniprot id: Q5RCN9
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL (By similarity).
messages: Membrane
messages: Phosphorylated on serine residues.
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LSM14A
gene id: 9601:LSM14A
uniprot id: A0A0A0MXP6
uniprot id: A0A2J8RQY6
uniprot id: A0A8I5TLJ6
uniprot id: Q5R4R4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LSM14 family.
messages: Component of a ribonucleoprotein (RNP) complex (By similarity). Interacts with DDX6. Interacts with EIF4ENIF1/4E-T; promoting EIF4ENIF1/4E-T localization to P-bodies. Interacts (via FFD box) with EDC4 (By similarity).
messages: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
messages: P-body
messages: Stress granule
messages: The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle

9601:ACTA2
gene id: 9601:ACTA2
uniprot id: Q5R5A2
names: Similarity
messages: Belongs to the actin family.

9601:ADGRF5
gene id: 9601:ADGRF5
uniprot id: A0A2J8Y516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9601:SPSB4
gene id: 9601:SPSB4
uniprot id: H2PBL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9601:SLC30A8
gene id: 9601:SLC30A8
uniprot id: H2PR25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

9601:KIZ
gene id: 9601:KIZ
uniprot id: H2P160
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9601:RFC5
gene id: 9601:RFC5
uniprot id: H2NIT6
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9601:FAM198B
gene id: 9601:FAM198B
uniprot id: Q5RA32
names: Similarity
messages: Belongs to the GASK family.

9601:SMAD5
gene id: 9601:SMAD5
uniprot id: A0A2J8VQ33
uniprot id: Q5R6H7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119. Interacts with ZNF8.
messages: Nucleus
messages: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity).
messages: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

9601:PCBD1
gene id: 9601:PCBD1
uniprot id: H2NAM7
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9601:RAB2A
gene id: 9601:RAB2A
uniprot id: A0A2J8UQV9
uniprot id: Q5R6B6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
messages: acrosome

9601:CAPZA2
gene id: 9601:CAPZA2
uniprot id: Q5R4P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9601:ZNF317
gene id: 9601:ZNF317
uniprot id: Q5RE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:EMCN
gene id: 9601:EMCN
uniprot id: A0A2J8TQI1
uniprot id: Q5RFI9
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
messages: Highly O-glycosylated. Sialic acid-rich glycoprotein (By similarity).
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VHL
gene id: 9601:VHL
uniprot id: Q5R798
names: Similarity
messages: Belongs to the VHL family.

9601:HMBOX1
gene id: 9601:HMBOX1
uniprot id: A0A2J8X5E5
uniprot id: A0A2J8X5E6
uniprot id: A0A6D2W2L9
uniprot id: A0A8I5YLA6
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CRYBB2
gene id: 9601:CRYBB2
uniprot id: H2P3W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9601:ADGRF3
gene id: 9601:ADGRF3
uniprot id: A0A2J8VMM0
uniprot id: A0A2J8VMN9
uniprot id: H2P6R9
names: Subcellular Location Annotation
messages: Membrane

9601:TMEM198
gene id: 9601:TMEM198
uniprot id: A0A6D2XJQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9601:KRT74
gene id: 9601:KRT74
uniprot id: H2NHE0
names: Similarity
messages: Belongs to the intermediate filament family.

9601:ILVBL
gene id: 9601:ILVBL
uniprot id: H2NXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9601:CCDC167
gene id: 9601:CCDC167
uniprot id: A0A663DCX5
uniprot id: H2PIW9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Membrane
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SUMO1
gene id: 9601:SUMO1
uniprot id: A0A2J8WUY8
uniprot id: Q5R6J4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (By similarity). Interacts with PRKN (By similarity). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (By similarity). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (By similarity). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (By similarity). Interacts with BHLHE40/DEC1 (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with SENP2 (By similarity). Interacts with HINT1 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.

9601:POLD3
gene id: 9601:POLD3
uniprot id: A0A2J8V1C5
uniprot id: A0A663DD93
uniprot id: H2NEN0
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF836
gene id: 9601:ZNF836
uniprot id: H2NZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:PGRMC1
gene id: 9601:PGRMC1
uniprot id: A0A2J8WWB7
uniprot id: Q5RED0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
messages: Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions. Interacts with FECH; the interaction results in decreased FECH activity (By similarity). Interacts with EGFR, CYP1A1 and CYP3A4; the interactions require PGRMC1 homodimerization (By similarity).
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Smooth endoplasmic reticulum membrane
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GNAI1
gene id: 9601:GNAI1
uniprot id: Q5RAD4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. Interacts (GDP-bound form) with GPSM1; this inhibits guanine nucleotide exchange and GTP binding. Interacts (GDP-bound form) with GPSM2 (via GoLoco domains); this inhibits guanine nucleotide exchange. Interacts with RGS10; this strongly enhances GTP hydrolysis. Interacts with RGS1 and RGS16; this strongly enhances GTPase activity. Interacts with RGS4. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains). Interacts with RGS3, RGS6, RGS7, RGS8, RGS17, RGS18 and RGS20 (in vitro). Interacts (GDP-bound form) with RIC8A (via C-terminus). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI1 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI1 (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity).
messages: Membrane
messages: Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation.
messages: Nucleus
messages: Palmitoylation at Cys-3 varies with membrane lipid composition.
messages: cell cortex
messages: centrosome

9601:RECQL5
gene id: 9601:RECQL5
uniprot id: Q5R5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9601:TPM3
gene id: 9601:TPM3
uniprot id: A0A2J8VFV2
uniprot id: A0A6D2Y8R7
uniprot id: Q5NVF2
uniprot id: Q5R4B9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:LOC100440422
gene id: 9601:LOC100440422
uniprot id: A0A6D2VVN8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZFX
gene id: 9601:ZFX
uniprot id: H2PV52
names: Subcellular Location Annotation
messages: Nucleus

9601:TAS2R3
gene id: 9601:TAS2R3
uniprot id: H2PNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:YIF1A
gene id: 9601:YIF1A
uniprot id: A0A6D2Y363
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9601:LOC100446877
gene id: 9601:LOC100446877
uniprot id: H2NFP6
names: Subcellular Location Annotation
messages: Membrane

9601:NRBF2
gene id: 9601:NRBF2
uniprot id: A0A2J8WR58
uniprot id: Q5R4C9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRBF family.
messages: Cytoplasm
messages: Interacts with PPARD and PPARG (By similarity). Interacts with SCOC (By similarity). Interacts with PPARA. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand. Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (By similarity).
messages: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity).
messages: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: autophagosome

9601:LOC100436290
gene id: 9601:LOC100436290
uniprot id: H2PXC8
names: Similarity
messages: Belongs to the SPAN-X family.

9601:LTA4H
gene id: 9601:LTA4H
uniprot id: Q5REQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9601:KRT19
gene id: 9601:KRT19
uniprot id: Q5R8S9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).
messages: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

9601:SEC24C
gene id: 9601:SEC24C
uniprot id: Q5R5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9601:AGK
gene id: 9601:AGK
uniprot id: A0A2J8V376
uniprot id: Q5RED7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AGK family.
messages: Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29.
messages: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (By similarity). Phosphorylates ceramide but not sphingosine (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (By similarity). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLDN14
gene id: 9601:CLDN14
uniprot id: A0A6D2XAZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:TRDN
gene id: 9601:TRDN
uniprot id: Q5RA47
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9601:USP5
gene id: 9601:USP5
uniprot id: Q5R407
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity).
messages: Interacts with TRIML1.

9601:SUB1
gene id: 9601:SUB1
uniprot id: A0A2J8WAX1
uniprot id: Q5R6D0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity).
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2 (By similarity).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PELI3
gene id: 9601:PELI3
uniprot id: A0A2J8U019
uniprot id: H2NCR5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9601:CDCA7L
gene id: 9601:CDCA7L
uniprot id: A0A2J8VE83
uniprot id: H2PMP7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:DTX3
gene id: 9601:DTX3
uniprot id: A0A2J8UH07
uniprot id: Q5REG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Deltex family.
messages: Cytoplasm
messages: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
messages: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TUBA4A
gene id: 9601:TUBA4A
uniprot id: A0A2J8TUH0
uniprot id: H2P8P0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9601:DTWD1
gene id: 9601:DTWD1
uniprot id: A0A2J8VBI0
uniprot id: Q5RCQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDD superfamily. DTWD1 family.
messages: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRR30
gene id: 9601:PRR30
uniprot id: A0A663DIS3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBL4A
gene id: 9601:UBL4A
uniprot id: Q5R4T1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and required for UBL4A protein stability. Interacts with USP13; may be indirect via BAG6.
messages: Nucleus
messages: Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.
messages: cytosol

9601:USP51
gene id: 9601:USP51
uniprot id: H2PVS9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9601:RBP4
gene id: 9601:RBP4
uniprot id: A0A2J8Y5C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9601:MITF
gene id: 9601:MITF
uniprot id: A0A2J8SWD2
uniprot id: A0A2J8SWD5
uniprot id: A0A2J8SWD7
uniprot id: A0A6D2XBZ6
uniprot id: H2PAA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRAPPC6B
gene id: 9601:TRAPPC6B
uniprot id: A0A663DFF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9601:KRR1
gene id: 9601:KRR1
uniprot id: H2NI38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9601:WDR12
gene id: 9601:WDR12
uniprot id: A0A2J8WUS6
uniprot id: Q5REE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus
messages: nucleoplasm

9601:FZD10
gene id: 9601:FZD10
uniprot id: H2NJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9601:PDE5A
gene id: 9601:PDE5A
uniprot id: A0A2J8XPU0
uniprot id: A0A2J8XQ41
uniprot id: H2PE75
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BDKRB2
gene id: 9601:BDKRB2
uniprot id: A0A2J8TLE0
uniprot id: A0A663D6H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GMPS
gene id: 9601:GMPS
uniprot id: Q5RA96
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
messages: Homodimer.
messages: cytosol

9601:WDR91
gene id: 9601:WDR91
uniprot id: H2PNL2
uniprot id: Q5R6T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.
messages: Interacts with WDR81; involved in early to late endosome cargo transport. Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes.
messages: Late endosome membrane
messages: Membrane

9601:LOC100448033
gene id: 9601:LOC100448033
uniprot id: A0A6D2Y9T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GTPBP10
gene id: 9601:GTPBP10
uniprot id: A0A6D2Y441
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9601:RPN1
gene id: 9601:RPN1
uniprot id: A0A2J8TVB6
uniprot id: Q5RFB6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Melanosome
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9601:ATP1A1
gene id: 9601:ATP1A1
uniprot id: Q5RDR3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Melanosome
messages: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts with SIK1. Interacts with SLC35G1 and STIM1. Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: axon
messages: sarcolemma

9601:KDELC2
gene id: 9601:KDELC2
uniprot id: H2NF76
names: Similarity
messages: Belongs to the KDELC family.

9601:HOXC9
gene id: 9601:HOXC9
uniprot id: A0A6D2W3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9601:RALA
gene id: 9601:RALA
uniprot id: H2PMB2
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9601:CELF2
gene id: 9601:CELF2
uniprot id: Q5R8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Interacts with A1CF.
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity).

9601:NPR3
gene id: 9601:NPR3
uniprot id: H2PFA1
names: Subcellular Location Annotation
messages: Membrane

9601:MMP15
gene id: 9601:MMP15
uniprot id: H2NR22
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:NSMCE2
gene id: 9601:NSMCE2
uniprot id: A0A2J8X2J1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DCP1B
gene id: 9601:DCP1B
uniprot id: H2NG36
uniprot id: Q5R413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCP1 family.
messages: Cytoplasm
messages: Interacts with DCP1A.
messages: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).
messages: Nucleus

9601:LY6D
gene id: 9601:LY6D
uniprot id: A0A663DE88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:LDB2
gene id: 9601:LDB2
uniprot id: A0A2J8ULK3
uniprot id: H2PCZ1
names: Caution
names: Similarity
messages: Belongs to the LDB family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MBTPS1
gene id: 9601:MBTPS1
uniprot id: Q5R4I7
names: Similarity
messages: Belongs to the peptidase S8 family.

9601:SLC25A20
gene id: 9601:SLC25A20
uniprot id: Q5R6H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:ANTXR2
gene id: 9601:ANTXR2
uniprot id: A0A2J8UUG3
uniprot id: H2PDQ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPLP1
gene id: 9601:RPLP1
uniprot id: H2NNM2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9601:LOC100441354
gene id: 9601:LOC100441354
uniprot id: A0A2J8X056
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PSMB9
gene id: 9601:PSMB9
uniprot id: H2PL27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9601:ANXA10
gene id: 9601:ANXA10
uniprot id: H2PEP8
names: Similarity
messages: Belongs to the annexin family.

9601:PSENEN
gene id: 9601:PSENEN
uniprot id: A0A8I5UC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9601:TPRA1
gene id: 9601:TPRA1
uniprot id: A0A2J8TV71
uniprot id: A0A6D2WNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9601:LOC100449010
gene id: 9601:LOC100449010
uniprot id: H2PCL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LSM3
gene id: 9601:LSM3
uniprot id: H2P9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9601:GMNN
gene id: 9601:GMNN
uniprot id: A0A2J8S4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9601:GPX8
gene id: 9601:GPX8
uniprot id: A0A2J8V5V1
uniprot id: A0A2J8V5W3
names: Caution
names: Similarity
messages: Belongs to the glutathione peroxidase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TEX13C
gene id: 9601:TEX13C
uniprot id: A0A2J8WWP0
names: Caution
names: Similarity
messages: Belongs to the TEX13 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRPF38A
gene id: 9601:PRPF38A
uniprot id: A0A2J8V8P3
uniprot id: Q5RDD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Component of the spliceosome B complex. Interacts (via N-terminal interaction domain) with ZMAT2 and MFAP1.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RAB5IF
gene id: 9601:RAB5IF
uniprot id: A0A8I5T2F6
names: Subcellular Location Annotation
messages: Membrane

9601:NODAL
gene id: 9601:NODAL
uniprot id: H2NAN3
names: Similarity
messages: Belongs to the TGF-beta family.

9601:CSTF1
gene id: 9601:CSTF1
uniprot id: H2P2C7
uniprot id: Q5R8K2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit) (By similarity). Interacts (via repeats WD) directly with CSTF3 (By similarity). Interacts (via repeat WD6) with BARD1 (By similarity). Interacts with ERCC6 (By similarity).
messages: N-terminus mediates homodimerization.
messages: Nucleus
messages: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).

9601:CORO7
gene id: 9601:CORO7
uniprot id: Q5RBW3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity).
messages: Golgi apparatus membrane
messages: Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15 (By similarity).
messages: The membrane-associated form is phosphorylated on tyrosine residues.
messages: Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID (By similarity).
messages: cytosol
messages: trans-Golgi network

9601:ST6GALNAC4
gene id: 9601:ST6GALNAC4
uniprot id: A0A6D2WT50
uniprot id: H2PTH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPV17
gene id: 9601:MPV17
uniprot id: A0A2J8VN06
uniprot id: A0A6D2VYS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9601:LOC100439688
gene id: 9601:LOC100439688
uniprot id: H2PDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:SLC52A1
gene id: 9601:SLC52A1
uniprot id: A0A6D2VUG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9601:TMEM86B
gene id: 9601:TMEM86B
uniprot id: H2P068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9601:LOC100450286
gene id: 9601:LOC100450286
uniprot id: H2NM38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9601:PPM1A
gene id: 9601:PPM1A
uniprot id: A0A6D2XKL9
uniprot id: H2NLE9
uniprot id: Q5R4N1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:USP29
gene id: 9601:USP29
uniprot id: A0A2J8RPY4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9601:GLYR1
gene id: 9601:GLYR1
uniprot id: Q5R7T2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome
messages: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.
messages: Homotetramere. Interacts with MAPK14. Interacts with KDM1B at nucleosomes; this interaction stimulates H3K4me1 and H3K4me2 demethylation. Binds to mononucleosomes. Interacts with GATA4; the interaction is required for a synergistic activation of GATA4 target genes transcription.
messages: In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
messages: Nucleus
messages: The A.T hook DNA-binding domain is required for the interaction with MAPK14.
messages: The PWWP domain is a H3 reader and strongly binds DNA.

9601:C1QBP
gene id: 9601:C1QBP
uniprot id: H2NSF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9601:LOC100442263
gene id: 9601:LOC100442263
uniprot id: H2P177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9601:C20H20orf27
gene id: 9601:C20H20orf27
uniprot id: H2P1B8
names: Similarity
messages: Belongs to the UPF0687 family.

9601:TATDN2
gene id: 9601:TATDN2
uniprot id: Q5RD90
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9601:S1PR2
gene id: 9601:S1PR2
uniprot id: A0A6D2VZI5
uniprot id: H2NXI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C6H6orf58
gene id: 9601:C6H6orf58
uniprot id: H2PKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9601:C19H19orf47
gene id: 9601:C19H19orf47
uniprot id: A0A2J8SDZ1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SH3BP5L
gene id: 9601:SH3BP5L
uniprot id: H2N340
uniprot id: Q5R9X9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9601:FAM83B
gene id: 9601:FAM83B
uniprot id: H2PJF1
names: Similarity
messages: Belongs to the FAM83 family.

9601:CTNNBL1
gene id: 9601:CTNNBL1
uniprot id: H2P1V7
names: Subcellular Location Annotation
messages: Nucleus

9601:GDF15
gene id: 9601:GDF15
uniprot id: H2NY34
names: Similarity
messages: Belongs to the TGF-beta family.

9601:DLAT
gene id: 9601:DLAT
uniprot id: H2NFA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9601:MVP
gene id: 9601:MVP
uniprot id: Q5R9N2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Dephosphorylated by PTPN11.
messages: MVP 3 mediates interaction with PTEN.
messages: MVP 4 mediates interaction with PARP4.
messages: Nucleus
messages: Phosphorylated on Tyr residues after EGF stimulation.
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540 (By similarity).

9601:NAA40
gene id: 9601:NAA40
uniprot id: Q5R9Y8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:ATP5MG
gene id: 9601:ATP5MG
uniprot id: Q5RFH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase g subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9601:CARNMT1
gene id: 9601:CARNMT1
uniprot id: H2PSE6
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9601:TMOD3
gene id: 9601:TMOD3
uniprot id: A0A6D2XSY8
uniprot id: H2NN88
names: Subcellular Location Annotation
messages: cytoskeleton

9601:TMEM200B
gene id: 9601:TMEM200B
uniprot id: A0A6D2XSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9601:ZNF350
gene id: 9601:ZNF350
uniprot id: A0A663D7Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:TUSC5
gene id: 9601:TUSC5
uniprot id: H2NS45
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9601:GCSAM
gene id: 9601:GCSAM
uniprot id: A0A663DI35
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RAB18
gene id: 9601:RAB18
uniprot id: A0A2J8SAG8
uniprot id: Q5R5H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts (in GTP-bound form) with ZFYVE1 (By similarity). Interacts with ZW10 and this interaction is enhanced in the presence of ZFYVE1 (By similarity). Interacts with BSCL2 (By similarity).
messages: Lipid droplet
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity).

9601:LOC100452405
gene id: 9601:LOC100452405
uniprot id: H2N8X9
names: Similarity
messages: Belongs to the FAM131 family.

9601:PHKG2
gene id: 9601:PHKG2
uniprot id: A0A6D2X6K1
uniprot id: H2NQP6
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9601:SERPINB9
gene id: 9601:SERPINB9
uniprot id: H2PHR5
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9601:NT5C1B
gene id: 9601:NT5C1B
uniprot id: A0A2J8RSM6
uniprot id: A0A6D2X673
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PIM2
gene id: 9601:PIM2
uniprot id: H2PVK4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9601:S100A15A
gene id: 9601:S100A15A
uniprot id: A7K6Y9
names: Similarity
messages: Belongs to the S-100 family.

9601:CD40LG
gene id: 9601:CD40LG
uniprot id: A0A2J8WX93
uniprot id: H2PWX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9601:WISP3
gene id: 9601:WISP3
uniprot id: A0A2J8U197
uniprot id: A0A6D2X2T2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLCN6
gene id: 9601:CLCN6
uniprot id: Q5RCM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:KCNV1
gene id: 9601:KCNV1
uniprot id: A0A2J8X351
uniprot id: Q5RC10
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TBX18
gene id: 9601:TBX18
uniprot id: H2PJQ4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:TAOK3
gene id: 9601:TAOK3
uniprot id: Q5R4F3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2 (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (By similarity).
messages: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity).

9601:ZNF507
gene id: 9601:ZNF507
uniprot id: Q5RDQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:SNCG
gene id: 9601:SNCG
uniprot id: A0A663D606
uniprot id: H2NAD4
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SND1
gene id: 9601:SND1
uniprot id: Q5R8N3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9601:EGFLAM
gene id: 9601:EGFLAM
uniprot id: A0A2J8WBA8
uniprot id: A0A2J8WBC7
uniprot id: H2PFD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRDM1
gene id: 9601:PRDM1
uniprot id: A0A2J8SFZ2
uniprot id: H2PJX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9601:TRMT61A
gene id: 9601:TRMT61A
uniprot id: H2NMC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9601:SNX33
gene id: 9601:SNX33
uniprot id: H2NNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9601:STAT3
gene id: 9601:STAT3
uniprot id: Q5RF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9601:PCMT1
gene id: 9601:PCMT1
uniprot id: Q5RA89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
messages: Monomer.
messages: cytosol

9601:PELO
gene id: 9601:PELO
uniprot id: Q5RCE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: Nucleus
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

9601:HAPLN2
gene id: 9601:HAPLN2
uniprot id: H2N5C5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:ARMCX2
gene id: 9601:ARMCX2
uniprot id: A0A2J8U638
uniprot id: Q5RFK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9601:GTF2E1
gene id: 9601:GTF2E1
uniprot id: A0A2J8W298
uniprot id: Q5R8H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE alpha subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRPC4
gene id: 9601:TRPC4
uniprot id: A0A8I5SYE1
uniprot id: H2NJN8
names: Subcellular Location Annotation
messages: Membrane

9601:SCD
gene id: 9601:SCD
uniprot id: Q5RAH2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9601:LOC100459764
gene id: 9601:LOC100459764
uniprot id: A0A2J8WN25
uniprot id: A0A6D2XN46
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9601:HSDL2
gene id: 9601:HSDL2
uniprot id: Q5RA68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Has apparently no steroid dehydrogenase activity.
messages: Peroxisome

9601:ACTA1
gene id: 9601:ACTA1
uniprot id: A0A2J8R810
uniprot id: Q5R9Q5
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha-actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:PTTG1
gene id: 9601:PTTG1
uniprot id: A0A6D2Y6Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9601:RPL31
gene id: 9601:RPL31
uniprot id: Q5RBR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9601:LEPROTL1
gene id: 9601:LEPROTL1
uniprot id: Q5RDE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane
messages: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).

9601:CBWD3
gene id: 9601:CBWD3
uniprot id: A0A8I5TUS1
uniprot id: Q5RAA1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9601:NRCAM
gene id: 9601:NRCAM
uniprot id: A0A2J8TA09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9601:STAMBPL1
gene id: 9601:STAMBPL1
uniprot id: H2NAY0
uniprot id: Q5R558
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase M67C family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The JAMM motif is essential for the protease activity.
messages: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains.

9601:ATXN7L3B
gene id: 9601:ATXN7L3B
uniprot id: A0A2J8W1F3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2D2
gene id: 9601:UBE2D2
uniprot id: A0A6D2VWS6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:MCMBP
gene id: 9601:MCMBP
uniprot id: A0A6D2XBY2
uniprot id: H2NBT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FOXB1
gene id: 9601:FOXB1
uniprot id: H2NNE2
names: Subcellular Location Annotation
messages: Nucleus

9601:ARPC5L
gene id: 9601:ARPC5L
uniprot id: A0A2J8SFR1
uniprot id: Q5R4M1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:LUM
gene id: 9601:LUM
uniprot id: Q5RFG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9601:NRP2
gene id: 9601:NRP2
uniprot id: A0A2J8WUL0
uniprot id: A0A2J8WUM3
uniprot id: A0A663DBF5
uniprot id: H2P8D7
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100451447
gene id: 9601:LOC100451447
uniprot id: A0A2J8UB84
uniprot id: H2PVU6
names: Caution
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LYSMD4
gene id: 9601:LYSMD4
uniprot id: Q5REP3
names: Subcellular Location Annotation
messages: Membrane

9601:MST1
gene id: 9601:MST1
uniprot id: H2PAR3
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:CAT
gene id: 9601:CAT
uniprot id: A0A2J8WG27
uniprot id: Q5RF10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
messages: Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAN1A1
gene id: 9601:MAN1A1
uniprot id: H2PK77
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9601:PDP2
gene id: 9601:PDP2
uniprot id: Q5RAA8
names: Similarity
messages: Belongs to the PP2C family.

9601:ZNF830
gene id: 9601:ZNF830
uniprot id: A0A6D2Y4J2
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9601:EXT1
gene id: 9601:EXT1
uniprot id: Q5RBC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
messages: Golgi apparatus membrane
messages: cis-Golgi network membrane

9601:CAMP
gene id: 9601:CAMP
uniprot id: H2PAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9601:AGFG1
gene id: 9601:AGFG1
uniprot id: A0A2J8SHT8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM83D
gene id: 9601:FAM83D
uniprot id: H2P1X4
names: Similarity
messages: Belongs to the FAM83 family.

9601:TMEM173
gene id: 9601:TMEM173
uniprot id: H2PGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9601:CTNND1
gene id: 9601:CTNND1
uniprot id: A0A2J8WE81
uniprot id: A0A2J8WE88
uniprot id: A0A2J8WEA4
uniprot id: Q5RAF5
names: Caution
names: Similarity
messages: Belongs to the beta-catenin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TPRG1L
gene id: 9601:TPRG1L
uniprot id: H2N9D5
names: Similarity
messages: Belongs to the TPRG1 family.

9601:UCN3
gene id: 9601:UCN3
uniprot id: H2N9N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9601:ZNF461
gene id: 9601:ZNF461
uniprot id: K7EUX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:KHDRBS1
gene id: 9601:KHDRBS1
uniprot id: A0A2J8Y7F3
names: Caution
names: Similarity
messages: Belongs to the KHDRBS family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL7
gene id: 9601:RPL7
uniprot id: A0A2J8VA72
uniprot id: Q5R9R4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit. Homodimer. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPA
gene id: 9601:CENPA
uniprot id: H2P6R0
names: Similarity
messages: Belongs to the histone H3 family.

9601:SLC12A4
gene id: 9601:SLC12A4
uniprot id: H2NRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9601:GDAP1
gene id: 9601:GDAP1
uniprot id: Q5RAG5
names: Similarity
messages: Belongs to the GST superfamily.

9601:TEX261
gene id: 9601:TEX261
uniprot id: Q5RFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9601:PHKA2
gene id: 9601:PHKA2
uniprot id: A0A8I5UKR2
uniprot id: H2PV23
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9601:PDHA1
gene id: 9601:PDHA1
uniprot id: Q5R490
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).
messages: Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity).
messages: Mitochondrion matrix
messages: Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Phosphorylation at Ser-293 interferes with access to active site, and thereby inactivates the enzyme. Dephosphorylation at all three sites, i.e. at Ser-232, Ser-293 and Ser-300, is required for reactivation (By similarity).
messages: Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9601:SLC25A15
gene id: 9601:SLC25A15
uniprot id: H2NJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:CNKSR3
gene id: 9601:CNKSR3
uniprot id: H2PKP2
names: Similarity
messages: Belongs to the CNKSR family.

9601:ZDHHC15
gene id: 9601:ZDHHC15
uniprot id: A0A2J8UT32
uniprot id: H2PW26
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9601:ZKSCAN1
gene id: 9601:ZKSCAN1
uniprot id: A0A2J8RUG8
uniprot id: H2PLK9
uniprot id: Q5R670
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LTV1
gene id: 9601:LTV1
uniprot id: Q5R8B2
names: Similarity
messages: Belongs to the LTV1 family.

9601:TIPARP
gene id: 9601:TIPARP
uniprot id: H2PBT8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9601:ASB3
gene id: 9601:ASB3
uniprot id: H2P682
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9601:RNF24
gene id: 9601:RNF24
uniprot id: A0A6D2XKG9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EXT2
gene id: 9601:EXT2
uniprot id: A0A2J8WFK4
uniprot id: A0A6D2XJX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITIH4
gene id: 9601:ITIH4
uniprot id: Q5R550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9601:LPAR4
gene id: 9601:LPAR4
uniprot id: H2PW41
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:ATG4B
gene id: 9601:ATG4B
uniprot id: A0A2J8RPS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: autophagosome
messages: cytosol

9601:TMEM41B
gene id: 9601:TMEM41B
uniprot id: Q5RBZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM41 family.
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Interacts with VMP1. Interacts with COPA, COPB1, VDAC1 and ERLIN2. Interacts with ATG2A. Interacts with SURF4.
messages: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity).
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

9601:FAM49B
gene id: 9601:FAM49B
uniprot id: A0A2J8X2G1
uniprot id: A0A6D2WTN7
uniprot id: A0A8I3B3M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9601:KCND3
gene id: 9601:KCND3
uniprot id: A0A2J8UM22
uniprot id: H2N6D2
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9601:CPS1
gene id: 9601:CPS1
uniprot id: A0A663DH15
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM101
gene id: 9601:TMEM101
uniprot id: A0A2J8UYA1
uniprot id: Q5RFN8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: May activate NF-kappa-B signaling pathways.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MSN
gene id: 9601:MSN
uniprot id: H2PVV3
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9601:STOML2
gene id: 9601:STOML2
uniprot id: H2PRU3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9601:ATP5F1C
gene id: 9601:ATP5F1C
uniprot id: A0A663D8K5
uniprot id: H2N9Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9601:APOPT1
gene id: 9601:APOPT1
uniprot id: A0A2J8SZE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9601:MEF2C
gene id: 9601:MEF2C
uniprot id: A0A2J8UX26
uniprot id: A0A2J8UX27
uniprot id: Q5R444
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity).
messages: Belongs to the MEF2 family.
messages: Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 and HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13. Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity). Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (By similarity). Interacts with JPH2; interaction specifically takes place with the Junctophilin-2 N-terminal fragment cleavage product of JPH2 (By similarity). Interacts (via MADS box) with SOX18 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-59; which enhances DNA binding activity. Phosphorylated on Ser-396; which is required for Lys-391 sumoylation and inhibits transcriptional activity.
messages: Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).
messages: Sumoylated on Lys-391 with SUMO2 but not SUMO1; which represses transcriptional activity.
messages: The beta domain is required for enhancement of transcriptional activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).
messages: sarcoplasm

9601:DPF1
gene id: 9601:DPF1
uniprot id: A0A2J8RE78
names: Similarity
messages: Belongs to the requiem/DPF family.

9601:C1H1orf56
gene id: 9601:C1H1orf56
uniprot id: A0A2J8VEY8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PACSIN1
gene id: 9601:PACSIN1
uniprot id: A0A2J8Y3C3
uniprot id: Q5R411
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PACSIN family.
messages: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Homodimer. May form heterooligomers with other PACSINs. Interacts with both COBL and DBNL. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts (via SH3 domain) with SYNJ1 and WASL. Interacts (via SH3 domain) with DNM1; the interaction is reduced by DNM1 phosphorylation. Interacts with DNM2 and DNM3. Interacts with MAPT. Interacts with EHD1 and EHD3. Interacts with TRPV4 (By similarity).
messages: Membrane
messages: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
messages: Synapse
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9601:A1CF
gene id: 9601:A1CF
uniprot id: Q5R9H4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity).
messages: Nucleus
messages: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity).
messages: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity (By similarity).

9601:CWC15
gene id: 9601:CWC15
uniprot id: A0A2J8XWM5
uniprot id: Q5RE65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC15 family.
messages: Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AP5M1
gene id: 9601:AP5M1
uniprot id: Q5RC75
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9601:KIAA0754
gene id: 9601:KIAA0754
uniprot id: A0A2J8Y6E8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FLVCR2
gene id: 9601:FLVCR2
uniprot id: H2NLU7
names: Subcellular Location Annotation
messages: Membrane

9601:CDK8
gene id: 9601:CDK8
uniprot id: H2NJG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:MPC1
gene id: 9601:MPC1
uniprot id: H2PKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9601:CHMP3
gene id: 9601:CHMP3
uniprot id: A0A2J8RNU9
uniprot id: Q5RAU5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Forms a metastable monomer in solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the autoinhibition of CHMP3 (By similarity). Interacts with VTA1 (By similarity).
messages: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:ARMC9
gene id: 9601:ARMC9
uniprot id: Q5R629
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity).
messages: centriole
messages: cilium
messages: cilium basal body

9601:NUP35
gene id: 9601:NUP35
uniprot id: A0A2J8RZ25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nuclear pore complex

9601:ERBB3
gene id: 9601:ERBB3
uniprot id: H2NHN2
uniprot id: Q5RB22
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane
messages: Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7, MYOC and MUC1. Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (By similarity).
messages: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
messages: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

9601:NDUFB4
gene id: 9601:NDUFB4
uniprot id: A0A2J8W241
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KPNA7
gene id: 9601:KPNA7
uniprot id: H2PLH7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9601:PRDM14
gene id: 9601:PRDM14
uniprot id: A0A8I5UDD5
uniprot id: H2PQI9
names: Subcellular Location Annotation
messages: Nucleus

9601:RAB11FIP4
gene id: 9601:RAB11FIP4
uniprot id: H2NT95
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9601:CACFD1
gene id: 9601:CACFD1
uniprot id: H2PTV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9601:LPIN3
gene id: 9601:LPIN3
uniprot id: H2P1Y2
names: Similarity
messages: Belongs to the lipin family.

9601:LUZP2
gene id: 9601:LUZP2
uniprot id: A0A2J8STX8
uniprot id: Q5R8Y4
names: Caution
names: Subcellular Location Annotation
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC42
gene id: 9601:CDC42
uniprot id: A0A6D2WT31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9601:SH3BGRL
gene id: 9601:SH3BGRL
uniprot id: A0A2J8USW6
uniprot id: Q5RFN7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
messages: Belongs to the SH3BGR family.
messages: Cell membrane
messages: Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.
messages: The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:CXCR5
gene id: 9601:CXCR5
uniprot id: H2NFI3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:TSPAN15
gene id: 9601:TSPAN15
uniprot id: H2NAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9601:MLF1
gene id: 9601:MLF1
uniprot id: Q5R4T3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MLF family.
messages: Cytoplasm
messages: Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of COP1 and activation of p53 (By similarity).
messages: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity).
messages: Nucleus
messages: Phosphorylation is required for binding to YWHAZ.
messages: cilium
messages: cilium basal body

9601:TRNAU1AP
gene id: 9601:TRNAU1AP
uniprot id: Q5R462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM TRSPAP family.
messages: Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes. Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec) (By similarity).
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).
messages: Nucleus

9601:PPOX
gene id: 9601:PPOX
uniprot id: A0A6D2XND6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9601:KTI12
gene id: 9601:KTI12
uniprot id: A0A2J8V8M8
names: Caution
names: Similarity
messages: Belongs to the KTI12 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HAGHL
gene id: 9601:HAGHL
uniprot id: H2NPM1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9601:LIX1
gene id: 9601:LIX1
uniprot id: H2PG61
names: Similarity
messages: Belongs to the LIX1 family.

9601:LOC100432670
gene id: 9601:LOC100432670
uniprot id: H2NHL5
names: Subcellular Location Annotation
messages: Membrane

9601:FUT7
gene id: 9601:FUT7
uniprot id: H2PU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9601:PPP1R3C
gene id: 9601:PPP1R3C
uniprot id: H2NB02
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9601:DYRK4
gene id: 9601:DYRK4
uniprot id: A0A2J8TAW7
uniprot id: A0A6D2VZU7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9601:SLC39A13
gene id: 9601:SLC39A13
uniprot id: Q5R6I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a zinc-influx transporter.
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Golgi apparatus membrane
messages: Homodimer.

9601:ELOVL4
gene id: 9601:ELOVL4
uniprot id: A0A2J8V2F3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9601:C4H4orf3
gene id: 9601:C4H4orf3
uniprot id: A0A2J8XPU6
uniprot id: Q5R4B0
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM46A
gene id: 9601:FAM46A
uniprot id: A0A2J8V2H8
uniprot id: A0A663D903
names: Caution
names: Similarity
messages: Belongs to the TENT family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYL4
gene id: 9601:MYL4
uniprot id: A0A2J8UZ62
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:INSIG1
gene id: 9601:INSIG1
uniprot id: H2PP51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9601:CASTOR1
gene id: 9601:CASTOR1
uniprot id: Q5R9D1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
messages: Belongs to the GATS family.
messages: Forms homodimers and heterodimers with CASTOR2 (By similarity). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (By similarity). Interacts with TM4SF5; the interaction is positively regulated by leucine and is negatively regulated by arginine (By similarity).
messages: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
messages: Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167.
messages: Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1.
messages: cytosol

9601:ABI1
gene id: 9601:ABI1
uniprot id: A0A2J8R0U4
uniprot id: A0A2J8R0U7
uniprot id: A0A2J8R0W0
uniprot id: A0A2J8R0W1
uniprot id: A0A2J8R0W5
uniprot id: A0A663D6L6
uniprot id: H2NA08
uniprot id: Q5R783
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9601:EAF2
gene id: 9601:EAF2
uniprot id: H2P9K9
names: Similarity
messages: Belongs to the EAF family.

9601:LMO3
gene id: 9601:LMO3
uniprot id: A0A2J8T1T8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM105A
gene id: 9601:FAM105A
uniprot id: H2PF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9601:MAOB
gene id: 9601:MAOB
uniprot id: Q5RE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9601:CXCL12
gene id: 9601:CXCL12
uniprot id: A0A2J8XT74
uniprot id: A0A2J8XTB3
uniprot id: Q5R8M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:CYP1B1
gene id: 9601:CYP1B1
uniprot id: A0A6D2X787
uniprot id: Q5RCF5
names: Caution
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100431565
gene id: 9601:LOC100431565
uniprot id: H2N586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ONECUT1
gene id: 9601:ONECUT1
uniprot id: A0A663DD36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VGLL3
gene id: 9601:VGLL3
uniprot id: A0A663D5S7
uniprot id: H2PA03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9601:THNSL2
gene id: 9601:THNSL2
uniprot id: Q5RFE6
names: Function
names: Similarity
messages: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
messages: Belongs to the threonine synthase family.

9601:MBNL2
gene id: 9601:MBNL2
uniprot id: A0A2J8X8P3
uniprot id: Q5R4F5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the muscleblind family.
messages: Cytoplasm
messages: Interacts with ITGA3.
messages: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PKIB
gene id: 9601:PKIB
uniprot id: A0A2J8TAB0
uniprot id: A0A2J8TAD1
names: Caution
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100446172
gene id: 9601:LOC100446172
uniprot id: A0A2J8WAM1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FIGN
gene id: 9601:FIGN
uniprot id: A0A6D2W9R9
names: Similarity
messages: Belongs to the AAA ATPase family.

9601:DMRTA2
gene id: 9601:DMRTA2
uniprot id: A0A2J8V8H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9601:CAPG
gene id: 9601:CAPG
uniprot id: A0A6D2X1Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9601:DNPH1
gene id: 9601:DNPH1
uniprot id: H2PJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9601:HOXB7
gene id: 9601:HOXB7
uniprot id: H2NVI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9601:PEBP1
gene id: 9601:PEBP1
uniprot id: A0A2J8XKC4
uniprot id: Q5R4R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
messages: Cytoplasm
messages: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
messages: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL37A
gene id: 9601:RPL37A
uniprot id: A0A2J8STV8
uniprot id: Q5RBF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GTPBP1
gene id: 9601:GTPBP1
uniprot id: Q5R8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
messages: Cytoplasm
messages: Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).

9601:ACTL10
gene id: 9601:ACTL10
uniprot id: H2P1P1
names: Similarity
messages: Belongs to the actin family.

9601:C9H9orf116
gene id: 9601:C9H9orf116
uniprot id: H2PTX2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9601:FCRLB
gene id: 9601:FCRLB
uniprot id: A0A2J8SLE3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NDUFAF4
gene id: 9601:NDUFAF4
uniprot id: Q5R4R9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.
messages: May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity).

9601:GRK6
gene id: 9601:GRK6
uniprot id: A0A2J8RDW2
uniprot id: A0A6D2X8Q0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9601:SPICE1
gene id: 9601:SPICE1
uniprot id: H2P9Q0
uniprot id: Q5RBY6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
messages: centriole
messages: spindle

9601:N4BP3
gene id: 9601:N4BP3
uniprot id: H2PHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9601:DGCR2
gene id: 9601:DGCR2
uniprot id: Q5R6P9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:UNC119B
gene id: 9601:UNC119B
uniprot id: A0A663D9V7
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9601:MRPS18A
gene id: 9601:MRPS18A
uniprot id: A0A6D2W7F4
names: Subcellular Location Annotation
messages: Mitochondrion

9601:MTMR4
gene id: 9601:MTMR4
uniprot id: A0A2J8W7U1
uniprot id: A0A6D2WY82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FOXO1
gene id: 9601:FOXO1
uniprot id: H2NJQ0
names: Subcellular Location Annotation
messages: Nucleus

9601:CUL1
gene id: 9601:CUL1
uniprot id: A0A2J8S6V6
uniprot id: Q5R4G6
uniprot id: Q5R6S8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (By similarity). Interacts with CCNF (By similarity). Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can self-associate. Interacts with F…
messages: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiq…
messages: Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CALU
gene id: 9601:CALU
uniprot id: A0A8J9E8Z2
uniprot id: Q5RDD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Interacts with GGCX.
messages: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9601:CMPK1
gene id: 9601:CMPK1
uniprot id: H2N7H2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9601:ZNF324
gene id: 9601:ZNF324
uniprot id: A0A6D2Y2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:PCOLCE2
gene id: 9601:PCOLCE2
uniprot id: A0A663DAH0
uniprot id: H2PBN3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATG4C
gene id: 9601:ATG4C
uniprot id: A0A6D2X341
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9601:BCHE
gene id: 9601:BCHE
uniprot id: A0A6D2XJ70
uniprot id: Q5R7Z4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF485
gene id: 9601:ZNF485
uniprot id: A0A2J8XT81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:PRM1
gene id: 9601:PRM1
uniprot id: H2NQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9601:FASLG
gene id: 9601:FASLG
uniprot id: A0A0U5J7R7
uniprot id: H2N4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9601:LOC100457717
gene id: 9601:LOC100457717
uniprot id: A0A2J8R6V5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:SETD9
gene id: 9601:SETD9
uniprot id: Q5RBW0
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.

9601:JAG1
gene id: 9601:JAG1
uniprot id: H2P116
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9601:PORCN
gene id: 9601:PORCN
uniprot id: H2PVI4
names: Subcellular Location Annotation
messages: Membrane

9601:G3BP1
gene id: 9601:G3BP1
uniprot id: A0A2J8X6D8
uniprot id: Q5RB87
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR.
messages: Homodimer and oligomer (By similarity). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP1 (By similarity). Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells (By similarity). No interaction in quiescent cells (By similarity). Interacts (via NTF2-like domain) with USP10. Interacts with RPTOR and SPAG5; this complex is increased by oxidative stress. Interacts with ATXN2L. Interacts with STYXL1. Interacts with CGAS (via N-terminus); this interaction promotes the DNA-binding and activation of CGAS. Interacts (via C-terminus) with RIGI. Interacts (via NTF2-like domain) with CAPRIN1. Interacts with PABPC1 (By similarity).
messages: Mg(2+) is required for helicase activity.
messages: Nucleus
messages: Perikaryon
messages: Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity. RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization (By similarity).
messages: Stress granule
messages: The NTF2 domain mediates multimerization.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:STAMBP
gene id: 9601:STAMBP
uniprot id: A0A6D2WTA6
names: Similarity
messages: Belongs to the peptidase M67C family.

9601:ZSCAN31
gene id: 9601:ZSCAN31
uniprot id: A0A2J8SJY7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NTF3
gene id: 9601:NTF3
uniprot id: H2NG72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9601:LOC100442553
gene id: 9601:LOC100442553
uniprot id: A0A663D706
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SMIM6
gene id: 9601:SMIM6
uniprot id: A0A2J8Y0Y1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPPE1
gene id: 9601:MPPE1
uniprot id: A0A2J8RFT9
uniprot id: A0A2J8RFU1
uniprot id: A0A6D2WKG8
uniprot id: H2NVU0
uniprot id: Q5RET5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity).
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9601:TMEM167B
gene id: 9601:TMEM167B
uniprot id: A0A2J8UMP9
uniprot id: Q5RAU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC39A10
gene id: 9601:SLC39A10
uniprot id: Q5R726
names: Subcellular Location Annotation
messages: Membrane

9601:EIF2S2
gene id: 9601:EIF2S2
uniprot id: Q5R4T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Interacts with BZW2/5MP1 and EIF5 (By similarity).
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).

9601:PEX5L
gene id: 9601:PEX5L
uniprot id: A0A2J8WGR5
uniprot id: A0A2J8WGT0
uniprot id: A0A2J8WGT5
uniprot id: A0A2J8WGU8
uniprot id: A0A2J8WGV7
uniprot id: A0A2J8WGV9
uniprot id: H2PC37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CEP120
gene id: 9601:CEP120
uniprot id: A0A2J8XE72
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM258
gene id: 9601:TMEM258
uniprot id: A0A2J8SMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9601:SAG
gene id: 9601:SAG
uniprot id: H2P8Z1
names: Similarity
messages: Belongs to the arrestin family.

9601:TMEM131L
gene id: 9601:TMEM131L
uniprot id: H2PEJ3
names: Similarity
messages: Belongs to the TMEM131 family.

9601:OTOP2
gene id: 9601:OTOP2
uniprot id: A0A6D2XNC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9601:TMEM202
gene id: 9601:TMEM202
uniprot id: A0A2J8UCS3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPN
gene id: 9601:CENPN
uniprot id: A0A2J8VWR3
uniprot id: A0A2J8VWR9
uniprot id: A0A2J8VWV1
uniprot id: A0A663DF43
uniprot id: H2NRK6
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9601:DLK1
gene id: 9601:DLK1
uniprot id: A0A2J8SZW6
uniprot id: H2NM96
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:SIAH2
gene id: 9601:SIAH2
uniprot id: H2PBR5
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9601:KIF2A
gene id: 9601:KIF2A
uniprot id: A0A2J8RL79
uniprot id: Q5R9Y9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
messages: Cytoplasm
messages: Interacts with AURKA, PSRC1 and PLK1.
messages: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: spindle
messages: spindle pole

9601:MTMR3
gene id: 9601:MTMR3
uniprot id: A0A2J8UUZ0
uniprot id: A0A2J8UUZ1
uniprot id: H2P405
uniprot id: Q5R6Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FNDC5
gene id: 9601:FNDC5
uniprot id: A0A2J8Y735
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATPAF2
gene id: 9601:ATPAF2
uniprot id: H2NSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9601:LXN
gene id: 9601:LXN
uniprot id: H2PBV1
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9601:BVES
gene id: 9601:BVES
uniprot id: A0A6D2W965
names: Similarity
messages: Belongs to the popeye family.

9601:CNN2
gene id: 9601:CNN2
uniprot id: A0A2J8R9Y7
uniprot id: Q5RFN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9601:POT1
gene id: 9601:POT1
uniprot id: Q5R7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9601:AIF1
gene id: 9601:AIF1
uniprot id: A0A2J8R4S6
uniprot id: A0A6D2X5G3
uniprot id: H2PII8
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: ruffle membrane

9601:SBK2
gene id: 9601:SBK2
uniprot id: A0A2J8R3H3
uniprot id: A0A6D2VW30
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DGLUCY
gene id: 9601:DGLUCY
uniprot id: Q5RBX1
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9601:EXOSC9
gene id: 9601:EXOSC9
uniprot id: H2PE83
names: Subcellular Location Annotation
messages: Cytoplasm

9601:NONO
gene id: 9601:NONO
uniprot id: A0A2J8UBM0
uniprot id: Q5RFL9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a pl…
messages: Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes (By similarity). Interacts with CPNE4 (via VWFA domain) (By similarity). Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 and SPIB. Interacts with RNF43 (By similarity). Interacts with PER1 and PER2 (By similarity). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts (via second RRM domain) with WASL; the interaction is direct. Component of a multiprotein complex with WASL and SFPQ (By similarity). Interacts with ERCC6 (By similarity). Interacts (via DNA-binding domain) with TET1 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:SLC28A3
gene id: 9601:SLC28A3
uniprot id: H2PSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9601:SFR1
gene id: 9601:SFR1
uniprot id: A0A8I5T5Q4
uniprot id: H2NBI7
uniprot id: K7ETC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9601:DHH
gene id: 9601:DHH
uniprot id: H2NH66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9601:RANBP17
gene id: 9601:RANBP17
uniprot id: H2PHC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9601:ZNF527
gene id: 9601:ZNF527
uniprot id: H2NYL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:RAD51D
gene id: 9601:RAD51D
uniprot id: Q5RCB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9601:NUP50
gene id: 9601:NUP50
uniprot id: A0A663D6F6
uniprot id: H2P4R1
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nuclear pore complex

9601:ZNF8
gene id: 9601:ZNF8
uniprot id: Q5REW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:IFNGR1
gene id: 9601:IFNGR1
uniprot id: A0A8I5TH90
uniprot id: Q5RF03
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9601:MTHFD1L
gene id: 9601:MTHFD1L
uniprot id: H2PKM4
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9601:TRAF2
gene id: 9601:TRAF2
uniprot id: H2PU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9601:MBNL1
gene id: 9601:MBNL1
uniprot id: A0A2J8WT39
uniprot id: A0A2J8WT50
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUAK2
gene id: 9601:NUAK2
uniprot id: Q5R7G9
names: Activity Regulation
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation on Thr-208.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-208.
messages: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.

9601:DHODH
gene id: 9601:DHODH
uniprot id: Q5R6X6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.

9601:PHACTR2
gene id: 9601:PHACTR2
uniprot id: A0A803KJK1
uniprot id: Q5R7W6
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TCAF1
gene id: 9601:TCAF1
uniprot id: H2PNW9
uniprot id: Q5R8R3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCAF family.
messages: Cell membrane
messages: Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
messages: Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
messages: The C-terminal region is necessary for the channel activity stimulation.

9601:SULT1C4
gene id: 9601:SULT1C4
uniprot id: A0A6D2XR91
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9601:C16H16orf91
gene id: 9601:C16H16orf91
uniprot id: A0A2J8R925
uniprot id: Q5RFR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GUCY1A2
gene id: 9601:GUCY1A2
uniprot id: H2NF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9601:CCDC65
gene id: 9601:CCDC65
uniprot id: H2NH56
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9601:BBOX1
gene id: 9601:BBOX1
uniprot id: Q5R5D8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9601:LOC100457574
gene id: 9601:LOC100457574
uniprot id: A0A5E3W7C8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane

9601:PSMC3IP
gene id: 9601:PSMC3IP
uniprot id: A0A2J8RF03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OXR1
gene id: 9601:OXR1
uniprot id: A0A2J8X3C5
names: Caution
names: Similarity
messages: Belongs to the OXR1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100436510
gene id: 9601:LOC100436510
uniprot id: H2PI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9601:ABCB8
gene id: 9601:ABCB8
uniprot id: Q5RFQ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit.
messages: Mitochondrion inner membrane
messages: The mitochondrial potassium channel (mitoK(ATP)) is composed of 4 subunits of CCDC51/MITOK and 4 subunits of ABCB8/MITOSUR. Physically interacts with PAAT. Interacts with Neuropilin-1 (NRP1) in mitochondria.

9601:XRCC3
gene id: 9601:XRCC3
uniprot id: A0A6D2Y7J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9601:DICER1
gene id: 9601:DICER1
uniprot id: A0A6D2VSB6
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9601:MAFB
gene id: 9601:MAFB
uniprot id: H2P1X7
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

9601:ADAM9
gene id: 9601:ADAM9
uniprot id: H2PQ47
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:SRI
gene id: 9601:SRI
uniprot id: A0A2J8WK94
uniprot id: Q5R4U9
names: Caution
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels (By similarity).
messages: Cytoplasm
messages: Homodimer. Interacts with GCA, RYR2 and ANXA7 (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein has been shown to bind calcium with high affinity.

9601:LOC100442629
gene id: 9601:LOC100442629
uniprot id: H2P178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9601:GMFB
gene id: 9601:GMFB
uniprot id: A0A2J8WKW8
uniprot id: Q5R6P6
names: Caution
names: Function
names: PTM
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Phosphorylated; stimulated by phorbol ester.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

9601:DSG4
gene id: 9601:DSG4
uniprot id: H2NW45
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9601:CTNND2
gene id: 9601:CTNND2
uniprot id: A0A2J8SHK0
uniprot id: A0A2J8SHK4
names: Caution
names: Similarity
messages: Belongs to the beta-catenin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100435022
gene id: 9601:LOC100435022
uniprot id: H2PI89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:ATXN10
gene id: 9601:ATXN10
uniprot id: H2P4S0
uniprot id: Q5RE06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ataxin-10 family.
messages: Homooligomer. Interacts with OGT. Interacts with GNB2. Interacts with IQCB1.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
messages: perinuclear region

9601:CEACAM1
gene id: 9601:CEACAM1
uniprot id: Q5R9N6
names: Subcellular Location Annotation
messages: Cell membrane

9601:ADI1
gene id: 9601:ADI1
uniprot id: H2P719
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9601:THEG
gene id: 9601:THEG
uniprot id: A0A2J8R0S3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GJB6
gene id: 9601:GJB6
uniprot id: A0A6D2WW92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:LOC100439532
gene id: 9601:LOC100439532
uniprot id: A0A6D2WS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:ADAMTS5
gene id: 9601:ADAMTS5
uniprot id: H2P2U4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9601:PHLDA1
gene id: 9601:PHLDA1
uniprot id: A0A2J8W1G8
names: Subcellular Location Annotation
messages: Cytoplasm

9601:CNNM2
gene id: 9601:CNNM2
uniprot id: A0A2J8XYT0
uniprot id: H2NBH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9601:ATF7
gene id: 9601:ATF7
uniprot id: Q5R9C9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with Ku complex components XRCC6 and XRCC7. Interacts with TERT.
messages: Nucleus
messages: On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity (By similarity). Social isolation stress as well as TNF-alpha also induce the phosphorylation of ATF7. Phosphorylated in proliferating colonic and small intestinal epithelial cells (By similarity).
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (By similarity). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (By similarity). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity).
messages: Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
messages: nucleoplasm
messages: telomere

9601:FKBP5
gene id: 9601:FKBP5
uniprot id: Q5RF88
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
messages: Inhibited by FK506 but not cyclosporin.
messages: Nucleus
messages: Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity). Interacts with IFI44L; this interaction modulates the kinase activity of IKBKB and IKBKE (By similarity). Interacts with IKBKB and IKBKE (By similarity).

9601:KRT39
gene id: 9601:KRT39
uniprot id: H2NU61
names: Similarity
messages: Belongs to the intermediate filament family.

9601:MAPT
gene id: 9601:MAPT
uniprot id: A0A2J8UZ01
uniprot id: A0A2J8UZ07
uniprot id: A0A2J8UZ09
uniprot id: A0A2J8UZ11
uniprot id: A0A2J8UZ15
uniprot id: A0A6D2VZT1
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: axon
messages: cytoskeleton
messages: cytosol

9601:FAM72A
gene id: 9601:FAM72A
uniprot id: A0A6D2XBH1
uniprot id: H2N3Y6
names: Caution
names: Similarity
messages: Belongs to the FAM72 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ANKRD27
gene id: 9601:ANKRD27
uniprot id: Q5REW9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Interacts with RAB21 (GDP-bound form), VPS29, KIF5A, KIF5C, GOLGA4. Interacts with RAB32 (GTP-bound form), RAB38 (GTP-bound form), VAMP7. Interacts with low affinity with RAB5. ANKRD27:RAB32 heterodimers can homodimerize to form tetramers. Can interact with RAB38 or RAB32, VPS29 and VAMP7 simultaneously (By similarity). A decreased interaction with RAB32 seen in the presence of SGSM2 (By similarity).
messages: Late endosome
messages: Lysosome
messages: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29. Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).
messages: Melanosome

9601:LOC100448637
gene id: 9601:LOC100448637
uniprot id: H2NXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:RAB22A
gene id: 9601:RAB22A
uniprot id: A0A6D2WZ50
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EWSR1
gene id: 9601:EWSR1
uniprot id: A0A2J8UUS1
uniprot id: A0A2J8UUS2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPOPL
gene id: 9601:SPOPL
uniprot id: A0A663D9P8
names: Similarity
messages: Belongs to the Tdpoz family.

9601:MYOD1
gene id: 9601:MYOD1
uniprot id: H2NDZ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9601:XPOT
gene id: 9601:XPOT
uniprot id: Q5RA02
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner (By similarity).
messages: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Nucleus

9601:STIM1
gene id: 9601:STIM1
uniprot id: H2NEH8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:NOB1
gene id: 9601:NOB1
uniprot id: A0A2J8VVJ6
uniprot id: Q5RBB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOB1 family.
messages: May interact with UPF2 (By similarity). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (By similarity).
messages: May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
messages: May play a role in mRNA degradation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARL2BP
gene id: 9601:ARL2BP
uniprot id: A0A2J8VZ19
uniprot id: Q5R9K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body
messages: spindle

9601:SLC5A5
gene id: 9601:SLC5A5
uniprot id: H2NY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9601:FOXN4
gene id: 9601:FOXN4
uniprot id: H2NIK5
names: Subcellular Location Annotation
messages: Nucleus

9601:PLBD2
gene id: 9601:PLBD2
uniprot id: A0A2J8XKW5
uniprot id: H2NIR9
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9601:LOC100460187
gene id: 9601:LOC100460187
uniprot id: A0A5C3FYQ5
uniprot id: H2PL41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9601:RPL13A
gene id: 9601:RPL13A
uniprot id: Q5RA38
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Citrullinated by PADI4.
messages: Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.
messages: Cytoplasm
messages: Phosphorylation at Ser-77 upon interferon-gamma treatment in macrophages involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.

9601:IFNG
gene id: 9601:IFNG
uniprot id: H2NHZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9601:FBXL2
gene id: 9601:FBXL2
uniprot id: Q5R3Z8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.
messages: Membrane
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL2) composed of CUL1, SKP1, RBX1 and FBXL2. Interacts with PCYT1A. Interacts with calmodulin; may antagonize substrate ubiquitination by SCF(FBXL2). Interacts with CCND2 and CCND3. Interacts with PIK3R2; PIK3R2 is a substrate ubiquitinated by the SCF(FBXL2) complex. May interact with PIK3R1. Interacts with PTPN13.
messages: The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex.

9601:NLK
gene id: 9601:NLK
uniprot id: H2NT22
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9601:CTNNBIP1
gene id: 9601:CTNNBIP1
uniprot id: A0A2J8USC0
names: Caution
names: Similarity
messages: Belongs to the CTNNBIP1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATG12
gene id: 9601:ATG12
uniprot id: A0A2J8XEH1
uniprot id: Q5R7W1
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300.
messages: Belongs to the ATG12 family.
messages: Cytoplasm
messages: Forms a conjugate with ATG5. The ATG12-ATG5 conjugate forms a complex with several units of ATG16L1. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). Interacts with ATG3, ATG7 and ATG10. ATG12-ATG5 also interacts with MAVS, MGA, RARRES3 and TECPR1 (By similarity). Interacts with SH3BGRL (By similarity).
messages: Preautophagosomal structure membrane
messages: Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminal Gly is required for isopeptide linkage.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity).

9601:PPM1B
gene id: 9601:PPM1B
uniprot id: H2P6D3
uniprot id: Q5R6P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9601:PSMD8
gene id: 9601:PSMD8
uniprot id: A0A2J8RE46
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9601:IFI6
gene id: 9601:IFI6
uniprot id: A0A2J8Y5T5
uniprot id: H2N8C7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EAF1
gene id: 9601:EAF1
uniprot id: A0A2J8U3V3
uniprot id: Q5RAM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional transactivator of ELL and ELL2 elongation activities.
messages: Belongs to the EAF family.
messages: Cajal body
messages: Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL and ELL2 (By similarity).
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACOT12
gene id: 9601:ACOT12
uniprot id: A0A2J8UWU4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TM4SF4
gene id: 9601:TM4SF4
uniprot id: Q5R6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane
messages: Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

9601:FLOT1
gene id: 9601:FLOT1
uniprot id: H2PIG3
uniprot id: Q5RBL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Melanosome
messages: Membrane
messages: Membrane raft
messages: caveola

9601:DDX43
gene id: 9601:DDX43
uniprot id: H2PJK8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9601:ARL11
gene id: 9601:ARL11
uniprot id: A0A2J8VSA1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9601:NDUFS4
gene id: 9601:NDUFS4
uniprot id: A0A2J8V606
uniprot id: P0CB95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:METTL6
gene id: 9601:METTL6
uniprot id: A0A2J8U3U9
uniprot id: A0A663D6L3
uniprot id: Q5RDV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Monomer. Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)-methylcytidine methylation.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9601:HIGD2A
gene id: 9601:HIGD2A
uniprot id: A0A6D2XQL6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9601:AASDHPPT
gene id: 9601:AASDHPPT
uniprot id: Q5NVE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Binds 1 Mg(2+) ion.
messages: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.
messages: Monomer.
messages: cytosol

9601:OPRM1
gene id: 9601:OPRM1
uniprot id: A0A2J8XAY2
uniprot id: A0A6D2WFV0
uniprot id: K7EUG7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: axon
messages: dendrite

9601:HPDL
gene id: 9601:HPDL
uniprot id: H2N7L4
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9601:FPR1
gene id: 9601:FPR1
uniprot id: A0A6D2X8J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GOT1
gene id: 9601:GOT1
uniprot id: A0A2J8XY48
uniprot id: Q5R691
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DEXI
gene id: 9601:DEXI
uniprot id: A0A6D2XJ68
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C8B
gene id: 9601:C8B
uniprot id: H2N790
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:HDAC9
gene id: 9601:HDAC9
uniprot id: Q5R6M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus

9601:LDB1
gene id: 9601:LDB1
uniprot id: A0A2J8XYH0
uniprot id: H2NBE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UNK
gene id: 9601:UNK
uniprot id: H2NUR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9601:GSPT2
gene id: 9601:GSPT2
uniprot id: Q5R4B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
messages: Cytoplasm
messages: Interacts with ETF1. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1 (By similarity).
messages: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).

9601:CHMP2A
gene id: 9601:CHMP2A
uniprot id: A0A6D2YA23
names: Similarity
messages: Belongs to the SNF7 family.

9601:LUC7L3
gene id: 9601:LUC7L3
uniprot id: A0A2J8W8B5
uniprot id: Q5R8W6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Luc7 family.
messages: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity).
messages: May interact with SFRS1 and form homodimers. Interacts with JMJD6. Interacts with RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with RRP1B.
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BAG5
gene id: 9601:BAG5
uniprot id: A0A6D2WD95
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TEF
gene id: 9601:TEF
uniprot id: A0A2J8TWS0
uniprot id: Q5R6E2
uniprot id: Q5R9N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9601:GBP5
gene id: 9601:GBP5
uniprot id: K7ETI9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9601:BGN
gene id: 9601:BGN
uniprot id: Q5RAY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9601:SH3BGRL3
gene id: 9601:SH3BGRL3
uniprot id: Q5RC61
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BGR family.
messages: Could act as a modulator of glutaredoxin biological activity (By similarity). May play a role in cytoskeleton organization (By similarity).
messages: Homodimer (By similarity). Interacts with MYO1C (via its IQ motifs); the interaction is dependent on calcium and takes place at membrane ruffles (By similarity).
messages: May be glycosylated.
messages: Nucleus
messages: cytosol
messages: ruffle membrane

9601:MLST8
gene id: 9601:MLST8
uniprot id: A0A6D2VS92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9601:KCNE4
gene id: 9601:KCNE4
uniprot id: H2P8R5
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9601:LOC100454483
gene id: 9601:LOC100454483
uniprot id: A0A6D2WI20
uniprot id: H2N6H4
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9601:SLC35F6
gene id: 9601:SLC35F6
uniprot id: Q5RFT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity).
messages: Lysosome membrane
messages: Mitochondrion

9601:TSPAN5
gene id: 9601:TSPAN5
uniprot id: A0A2J8TQS3
uniprot id: A0A663DJ51
uniprot id: H2PDY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NFIL3
gene id: 9601:NFIL3
uniprot id: H2PSN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9601:GABBR1
gene id: 9601:GABBR1
uniprot id: Q5R970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9601:CD79B
gene id: 9601:CD79B
uniprot id: A0A2J8UZQ1
uniprot id: A0A2J8UZR3
uniprot id: H2NUF5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADAM17
gene id: 9601:ADAM17
uniprot id: H2P701
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:LOC100437488
gene id: 9601:LOC100437488
uniprot id: A0A663D645
uniprot id: H2PDK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC103891398
gene id: 9601:LOC103891398
uniprot id: H2N5R4
names: Similarity
messages: Belongs to the LCE family.

9601:POLR1A
gene id: 9601:POLR1A
uniprot id: Q5RAX8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9601:CDC42EP1
gene id: 9601:CDC42EP1
uniprot id: H2P4A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9601:CCNT2
gene id: 9601:CCNT2
uniprot id: A0A2J8T224
uniprot id: H2P7F1
names: Similarity
messages: Belongs to the cyclin family.

9601:MID1
gene id: 9601:MID1
uniprot id: A0A6D2W764
uniprot id: Q5RFL0
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9601:ZNF786
gene id: 9601:ZNF786
uniprot id: H2PNY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:DNAJC7
gene id: 9601:DNAJC7
uniprot id: Q5R8D8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
messages: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3; this complex may also include HSP90. Interacts with HSPA8 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton

9601:ABLIM3
gene id: 9601:ABLIM3
uniprot id: Q5R5N1
names: Subcellular Location Annotation
messages: Cytoplasm

9601:CLDN24
gene id: 9601:CLDN24
uniprot id: H2PET8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:LIN7B
gene id: 9601:LIN7B
uniprot id: A0A6D2XVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9601:VPS72
gene id: 9601:VPS72
uniprot id: A0A2J8VF04
uniprot id: Q5R5V9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS72/YL1 family.
messages: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ. Interacts (via N-terminal domain) with H2AZ1; the interaction is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Nucleus
messages: Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF577
gene id: 9601:ZNF577
uniprot id: A0A2J8U9G5
uniprot id: A0A2J8U9G6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARFGAP2
gene id: 9601:ARFGAP2
uniprot id: Q5RAT7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).
messages: Golgi apparatus membrane
messages: Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1 (By similarity).

9601:SAFB
gene id: 9601:SAFB
uniprot id: A0A2J8SC35
uniprot id: A0A2J8SC38
uniprot id: Q5R452
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
messages: Monomer and homodimer (By similarity). Interacts with KHDRBS3 (By similarity). Interacts with CLK2 (By similarity). Interacts with POLR2A, ASF/SRSF1, SRp30c/SRFS9 and TRA2B/SFRS10 (By similarity). Interacts with SRPK1 and inhibits its activity (By similarity). Interacts with RBMX (By similarity). Interacts with FUS (By similarity). Interacts with ZBED4 (By similarity).
messages: Nucleus
messages: Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100431299
gene id: 9601:LOC100431299
uniprot id: A0A2J8SQS4
uniprot id: Q5RCS7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9601:PPP1R3B
gene id: 9601:PPP1R3B
uniprot id: A0A6D2WHK7
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9601:CYLD
gene id: 9601:CYLD
uniprot id: A0A2J8VY99
uniprot id: Q5RED8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Cell membrane
messages: Cytoplasm
messages: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins. Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, …
messages: Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and RIGI. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3 (By similarity). Interacts with MAP3K7. Identified in a complex with TRAF6 and SQSTM1 (By similarity). Interacts with OPTN and SQSTM1 (By similarity). Interacts with CEP350. Interacts with RNF31; the interaction is indirect and is mediated via SPATA2. Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity).
messages: Membrane
messages: Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B (By similarity).
messages: Ubiquitinated. Polyubiquitinated in hepatocytes treated with palmitic acid. Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.
messages: centrosome
messages: cilium basal body
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9601:RPF1
gene id: 9601:RPF1
uniprot id: A0A2J8WQF7
uniprot id: Q5R631
names: Caution
names: Function
names: Subcellular Location Annotation
messages: May be required for ribosome biogenesis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:BTBD10
gene id: 9601:BTBD10
uniprot id: Q5R585
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via C-terminal 330-amino-acid region) with AKT1; AKT2 and AKT3. Interacts with PPP2CA and PPP1CA.
messages: Nucleus
messages: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells.

9601:TAS2R8
gene id: 9601:TAS2R8
uniprot id: H2NGJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:SDHB
gene id: 9601:SDHB
uniprot id: H2N8W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9601:TRPC5
gene id: 9601:TRPC5
uniprot id: H2PWI3
names: Subcellular Location Annotation
messages: Membrane

9601:CALHM2
gene id: 9601:CALHM2
uniprot id: A0A6D2W0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9601:RIPK2
gene id: 9601:RIPK2
uniprot id: H2PQR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9601:RPP30
gene id: 9601:RPP30
uniprot id: A0A663D7P5
uniprot id: Q5RC47
names: Caution
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUP88
gene id: 9601:NUP88
uniprot id: Q5R5Q1
names: Subcellular Location Annotation
messages: nuclear pore complex

9601:NPL
gene id: 9601:NPL
uniprot id: A0A2J8V835
uniprot id: A0A2J8V838
uniprot id: A0A6D2Y5W5
uniprot id: Q5RDY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

9601:SLC26A6
gene id: 9601:SLC26A6
uniprot id: A0A2J8TFZ5
uniprot id: H2PAT8
uniprot id: Q5R7H3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BSCL2
gene id: 9601:BSCL2
uniprot id: A0A2J8TXW5
uniprot id: A0A2J8TXY1
uniprot id: A0A2J8TXY3
uniprot id: Q5R7Q9
uniprot id: Q5R9K3
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CXXC5
gene id: 9601:CXXC5
uniprot id: A0A2J8VPH6
uniprot id: Q5R7N4
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DVL1 (By similarity). Interacts with RBPJ (By similarity).
messages: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
messages: Nucleus
messages: The CXXC zinc finger mediates binding to CpG-DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STRADA
gene id: 9601:STRADA
uniprot id: Q5RBJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
messages: Cytoplasm
messages: Nucleus
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

9601:RPSA
gene id: 9601:RPSA
uniprot id: A0A2J8WY29
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9601:ALCAM
gene id: 9601:ALCAM
uniprot id: H2P9U5
uniprot id: Q5R640
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9601:OPN1SW
gene id: 9601:OPN1SW
uniprot id: H2PNG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9601:AVL9
gene id: 9601:AVL9
uniprot id: H2PMF8
uniprot id: Q5R991
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVL9 family.
messages: Endosome
messages: Functions in cell migration.
messages: Membrane
messages: Recycling endosome

9601:NT5C3B
gene id: 9601:NT5C3B
uniprot id: H2NU22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9601:MRPL57
gene id: 9601:MRPL57
uniprot id: A0A6D2WBL2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF41
gene id: 9601:ZNF41
uniprot id: A0A6D2XHC7
uniprot id: Q5R459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SLC43A2
gene id: 9601:SLC43A2
uniprot id: Q5RF58
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Affinity and transport activity are regulated by a phosphorylation switch state at Ser-274 and Ser-297; increasing of affinity and amino acid transport activity via dephosphorylation at Ser-274 and phosphorylation at Ser-297.
messages: Basolateral cell membrane
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Cell membrane
messages: Dephosphorylation at Ser-274 and phosphorylation at Ser-297 increase affinity and amino acid transport activity. Phosphorylation-dephosphorylation cycle is regulated by food-entrained diurnal rhythm and dietary proteins.
messages: Glycosylated.
messages: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent.

9601:ZHX1
gene id: 9601:ZHX1
uniprot id: A0A6D2Y7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9601:SLC29A2
gene id: 9601:SLC29A2
uniprot id: Q5R8Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9601:CHRM2
gene id: 9601:CHRM2
uniprot id: A0A2J8V3M8
uniprot id: A0A6D2W8H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MOB1B
gene id: 9601:MOB1B
uniprot id: A0A2J8UTT6
uniprot id: H2PDJ2
names: Similarity
messages: Belongs to the MOB1/phocein family.

9601:TSEN34
gene id: 9601:TSEN34
uniprot id: A0A2J8XR52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9601:WARS
gene id: 9601:WARS
uniprot id: Q5RDG6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9601:GLRB
gene id: 9601:GLRB
uniprot id: A0A2J8W0C0
uniprot id: A0A6D2XLG8
uniprot id: Q5R9Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:PTK6
gene id: 9601:PTK6
uniprot id: H2P2M1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9601:CHAC2
gene id: 9601:CHAC2
uniprot id: A0A8I5T6C6
uniprot id: H2P684
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9601:HOXC8
gene id: 9601:HOXC8
uniprot id: H2NHI9
names: Subcellular Location Annotation
messages: Nucleus

9601:AOC3
gene id: 9601:AOC3
uniprot id: A0A2J8RES3
uniprot id: Q5R9I0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper/topaquinone oxidase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 2 calcium ions per subunit.
messages: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity).
messages: Contains 1 topaquinone per subunit.
messages: Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC2 (By similarity).
messages: Membrane
messages: N- and O-glycosylated.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9601:NFIA
gene id: 9601:NFIA
uniprot id: Q5R5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9601:C7H7orf57
gene id: 9601:C7H7orf57
uniprot id: A0A2J8U2L7
uniprot id: A0A2J8U2M1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BCLAF3
gene id: 9601:BCLAF3
uniprot id: A0A663DFY3
uniprot id: H2PV31
names: Caution
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM98
gene id: 9601:TMEM98
uniprot id: A0A6D2WVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9601:VSTM5
gene id: 9601:VSTM5
uniprot id: H2NEZ4
names: Subcellular Location Annotation
messages: Membrane

9601:DEFB126
gene id: 9601:DEFB126
uniprot id: H2P1I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9601:SLC12A2
gene id: 9601:SLC12A2
uniprot id: A0A663DCH2
uniprot id: K7EVG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9601:PZP
gene id: 9601:PZP
uniprot id: H2NGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9601:ZNF202
gene id: 9601:ZNF202
uniprot id: A0A6D2XZS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:EPS8L2
gene id: 9601:EPS8L2
uniprot id: A0A2J8XSA1
uniprot id: Q5RC07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPS8 family.
messages: Cytoplasm
messages: Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin (By similarity).
messages: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: stereocilium

9601:LTA
gene id: 9601:LTA
uniprot id: H2PII0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9601:HSF4
gene id: 9601:HSF4
uniprot id: H2NR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9601:ARL8A
gene id: 9601:ARL8A
uniprot id: H2N463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9601:KLC3
gene id: 9601:KLC3
uniprot id: Q5R8E2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity).
messages: Mitochondrion
messages: Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C. Interacts with ODF1. Interacts with LRGUK (By similarity). Interacts with VDAC2 (By similarity).
messages: The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
messages: cytoskeleton

9601:FUT9
gene id: 9601:FUT9
uniprot id: H2PJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9601:ZKSCAN4
gene id: 9601:ZKSCAN4
uniprot id: H2PIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:CRBN
gene id: 9601:CRBN
uniprot id: Q5R6Y2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRBN family.
messages: Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts directly with DDB1 (By similarity). Interacts with KCNT1 (By similarity). Interacts with ILF2 (By similarity).
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity).
messages: Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.

9601:LOC100461542
gene id: 9601:LOC100461542
uniprot id: H2NKP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PLLP
gene id: 9601:PLLP
uniprot id: A0A663DC49
uniprot id: H2NR00
names: Subcellular Location Annotation
messages: Membrane

9601:CHORDC1
gene id: 9601:CHORDC1
uniprot id: Q5RD91
names: Function
names: Subunit
messages: Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.
messages: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity).

9601:WNT2B
gene id: 9601:WNT2B
uniprot id: A0A2J8UM15
uniprot id: H2N6D1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:LOC100442161
gene id: 9601:LOC100442161
uniprot id: A0A2J8S4Y0
uniprot id: Q5R893
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid (By similarity).
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPR137
gene id: 9601:GPR137
uniprot id: H2ND01
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9601:YBEY
gene id: 9601:YBEY
uniprot id: A0A6D2WAB1
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9601:IRF9
gene id: 9601:IRF9
uniprot id: H2NKV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:MAP7D2
gene id: 9601:MAP7D2
uniprot id: Q5R7F9
names: Similarity
messages: Belongs to the MAP7 family.

9601:SLC35E3
gene id: 9601:SLC35E3
uniprot id: H2NI00
names: Subcellular Location Annotation
messages: Membrane

9601:PSMC6
gene id: 9601:PSMC6
uniprot id: A0A6D2XES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9601:BST1
gene id: 9601:BST1
uniprot id: Q5NVG3
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9601:FLRT3
gene id: 9601:FLRT3
uniprot id: Q5R6T0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (By similarity). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).
messages: Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (By similarity). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct. Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct. Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (By similarity). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).
messages: N-glycosylated.
messages: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
messages: Secreted
messages: axon
messages: focal adhesion
messages: growth cone membrane

9601:IL21
gene id: 9601:IL21
uniprot id: H2PE90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9601:TNFRSF19
gene id: 9601:TNFRSF19
uniprot id: Q5RBW5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:BNIP1
gene id: 9601:BNIP1
uniprot id: H2PHE2
uniprot id: K7EV77
names: Subcellular Location Annotation
messages: Membrane

9601:MRPL41
gene id: 9601:MRPL41
uniprot id: H2PU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9601:PRRT1
gene id: 9601:PRRT1
uniprot id: A0A663DDY3
uniprot id: H2PIM9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9601:LOC100438895
gene id: 9601:LOC100438895
uniprot id: H2NED8
names: Similarity
messages: Belongs to the globin family.

9601:SUN2
gene id: 9601:SUN2
uniprot id: A0A6D2XBX3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:S1PR1
gene id: 9601:S1PR1
uniprot id: H2N6L9
uniprot id: Q5R7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:LIPT1
gene id: 9601:LIPT1
uniprot id: A0A6D2Y5S7
names: Similarity
messages: Belongs to the LplA family.

9601:PGM3
gene id: 9601:PGM3
uniprot id: A0A2J8V2J3
uniprot id: A0A6D2Y3I2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NME9
gene id: 9601:NME9
uniprot id: A0A2J8TTP8
names: Similarity
messages: Belongs to the NDK family.

9601:GUF1
gene id: 9601:GUF1
uniprot id: H2PD76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9601:SLC25A53
gene id: 9601:SLC25A53
uniprot id: H2PWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:HK3
gene id: 9601:HK3
uniprot id: H2PHH1
names: Similarity
messages: Belongs to the hexokinase family.

9601:HILPDA
gene id: 9601:HILPDA
uniprot id: A0A6D2W3X6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPBAR1
gene id: 9601:GPBAR1
uniprot id: A0A6D2VWV8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UNC45A
gene id: 9601:UNC45A
uniprot id: Q5RAP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity).
messages: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).
messages: Nucleus
messages: perinuclear region

9601:GAR1
gene id: 9601:GAR1
uniprot id: A0A6D2X8C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9601:LOC100455036
gene id: 9601:LOC100455036
uniprot id: H2PWV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:NTNG1
gene id: 9601:NTNG1
uniprot id: A0A2J8UMV6
uniprot id: H2N6L5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:HAPLN4
gene id: 9601:HAPLN4
uniprot id: H2NY57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:FLAD1
gene id: 9601:FLAD1
uniprot id: H2N5J1
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9601:CFH
gene id: 9601:CFH
uniprot id: A0A2J8UXY4
uniprot id: H2N4B3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:PANK4
gene id: 9601:PANK4
uniprot id: Q5R5F8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.
messages: Cytoplasm
messages: Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity.
messages: Homodimer. Interacts with PKM.
messages: In the C-terminal section; belongs to the damage-control phosphatase family. Phosphopantetheine phosphatase II subfamily.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.
messages: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
messages: Subfamily II proteins have an EGMGR motif about 50 residues from the C-terminus (By similarity). This motif lies near the metal-binding residues in the putative substrate-binding cleft 2 (By similarity). Subfamily II proteins occur only in eukaryotes, in two forms: as a stand-alone unit in plants, and as a C-terminal domain of pantothenate kinases in plants, animals, and chytrid fungi (By similarity).

9601:TRIM32
gene id: 9601:TRIM32
uniprot id: A0A2J8WRM4
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9601:PRDM5
gene id: 9601:PRDM5
uniprot id: A0A2J8XPT6
uniprot id: H2PE77
names: Subcellular Location Annotation
messages: Nucleus

9601:DYNLT3
gene id: 9601:DYNLT3
uniprot id: A0A2J8WIZ3
uniprot id: Q5NVF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: kinetochore

9601:MTFR1L
gene id: 9601:MTFR1L
uniprot id: A0A2J8SIM9
uniprot id: A0A2J8SIN4
uniprot id: A0A2J8SIP6
uniprot id: Q5R3Z9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HIP1R
gene id: 9601:HIP1R
uniprot id: Q5RD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

9601:AGPAT5
gene id: 9601:AGPAT5
uniprot id: Q5RFH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:ACTRT2
gene id: 9601:ACTRT2
uniprot id: H2N9D9
names: Similarity
messages: Belongs to the actin family.

9601:DNTT
gene id: 9601:DNTT
uniprot id: A0A2J8Y546
uniprot id: H2NB52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DMKN
gene id: 9601:DMKN
uniprot id: A0A2J8RRH9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OTUD7B
gene id: 9601:OTUD7B
uniprot id: H2N606
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:PATL1
gene id: 9601:PATL1
uniprot id: Q5R8Q4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4-NOT complex. Interacts with the Lsm-containing SMN-Sm protein complex. Interacts with EIF4ENIF1/4E-T.
messages: Nucleus
messages: Nucleus speckle
messages: P-body
messages: PML body
messages: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.
messages: The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain.

9601:LOC100435108
gene id: 9601:LOC100435108
uniprot id: H2PBK8
names: Similarity
messages: Belongs to the PRR23 family.

9601:PTK2B
gene id: 9601:PTK2B
uniprot id: Q5R7F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9601:SLC9B1
gene id: 9601:SLC9B1
uniprot id: A0A2J8XQP2
uniprot id: H2PE09
names: Subcellular Location Annotation
messages: Membrane

9601:CCR4
gene id: 9601:CCR4
uniprot id: A0A663D5P9
names: Caution
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OGG1
gene id: 9601:OGG1
uniprot id: H2PA53
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9601:VEGFB
gene id: 9601:VEGFB
uniprot id: A0A2J8TYH2
uniprot id: H2ND05
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITIH5
gene id: 9601:ITIH5
uniprot id: Q5RER0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: May act as a tumor suppressor.
messages: Secreted

9601:FOXD3
gene id: 9601:FOXD3
uniprot id: H2N765
names: Subcellular Location Annotation
messages: Nucleus

9601:CAVIN3
gene id: 9601:CAVIN3
uniprot id: H2NEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9601:GRAP2
gene id: 9601:GRAP2
uniprot id: A0A6D2WQ95
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9601:LOC100457779
gene id: 9601:LOC100457779
uniprot id: H2NYW8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:SLC19A2
gene id: 9601:SLC19A2
uniprot id: H2N4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9601:RAP2B
gene id: 9601:RAP2B
uniprot id: H2PBS6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9601:LOC100438608
gene id: 9601:LOC100438608
uniprot id: H2PI55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9601:LOC100447051
gene id: 9601:LOC100447051
uniprot id: H2PEY1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9601:CDKN2AIPNL
gene id: 9601:CDKN2AIPNL
uniprot id: H2PGK3
names: Similarity
messages: Belongs to the CARF family.

9601:MEIS1
gene id: 9601:MEIS1
uniprot id: A0A2J8XC44
uniprot id: A0A6D2WJ47
uniprot id: H2P607
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9601:NUP85
gene id: 9601:NUP85
uniprot id: A0A6D2VZ68
uniprot id: H2NUP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nuclear pore complex

9601:LOC100452634
gene id: 9601:LOC100452634
uniprot id: H2N352
names: Subcellular Location Annotation
messages: Membrane

9601:CLDN1
gene id: 9601:CLDN1
uniprot id: H2PCB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:SNX31
gene id: 9601:SNX31
uniprot id: H2PQX6
names: Similarity
messages: Belongs to the sorting nexin family.

9601:OSBPL2
gene id: 9601:OSBPL2
uniprot id: A0A2J8TX54
uniprot id: A0A6D2X9X9
uniprot id: H2P2I2
names: Caution
names: Similarity
messages: Belongs to the OSBP family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RANBP3
gene id: 9601:RANBP3
uniprot id: Q5R4Y2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity).
messages: Cytoplasm
messages: Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling (By similarity).
messages: Nucleus

9601:RAPGEF4
gene id: 9601:RAPGEF4
uniprot id: A0A2J8VR01
uniprot id: A0A2J8VR03
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100439033
gene id: 9601:LOC100439033
uniprot id: H2NGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:ENDOG
gene id: 9601:ENDOG
uniprot id: A0A663DFC8
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9601:CSN2
gene id: 9601:CSN2
uniprot id: H2PDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Secreted

9601:LOC100451987
gene id: 9601:LOC100451987
uniprot id: A0A8I5U358
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.
messages: Nucleus

9601:CRIPT
gene id: 9601:CRIPT
uniprot id: A0A663D770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9601:RPS6KC1
gene id: 9601:RPS6KC1
uniprot id: A0A2J8V648
uniprot id: A0A6D2YAS9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEC61G
gene id: 9601:SEC61G
uniprot id: A0A6D2WD85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SLC25A2
gene id: 9601:SLC25A2
uniprot id: H2PGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:CNTN1
gene id: 9601:CNTN1
uniprot id: A0A2J8WCC4
uniprot id: A0A6D2Y6P5
uniprot id: Q5RDU0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9601:NKRF
gene id: 9601:NKRF
uniprot id: A0A2J8WWF1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPARGC1A
gene id: 9601:PPARGC1A
uniprot id: H2PD10
uniprot id: Q5RBY0
names: Subcellular Location Annotation
messages: Nucleus
messages: PML body

9601:VWC2L
gene id: 9601:VWC2L
uniprot id: H2P8H8
names: Subcellular Location Annotation
messages: Synapse

9601:RARS
gene id: 9601:RARS
uniprot id: Q5RA20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
messages: Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via C-terminus). Monomer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Interacts with QARS1. Part of a complex composed of RARS1, QARS1 and AIMP1.
messages: The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.
messages: cytosol

9601:SLC43A3
gene id: 9601:SLC43A3
uniprot id: H2NDG4
names: Subcellular Location Annotation
messages: Membrane

9601:KCNJ8
gene id: 9601:KCNJ8
uniprot id: A0A6D2WZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9601:DMRTA1
gene id: 9601:DMRTA1
uniprot id: H2PS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9601:PIK3R1
gene id: 9601:PIK3R1
uniprot id: Q5R685
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the PI3K p85 subunit family.
messages: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
messages: Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts (via SH2 domains) with CCDC88A/GIV (tyrosine-phosphorylated form); the interaction enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Interacts with phosphorylated LAT, LAX1, TRAT1 and LIME1 upon TCR and/or BCR activation. Interacts with CBLB. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with SOCS7. Interacts with IRS1 and phosphorylated IRS4. Interacts with NISCH, RUFY3 and HCST. Interacts with AXL, FASLG, FER, FGR, HCK, KIT and BCR. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity. Interacts with NTRK1 (phosphorylated upon ligand-binding). Interacts with PTK2/FAK1. Interacts with PIK3R2; the interaction is dissociated in an insulin-dependent manner. Interacts with XBP1; the interaction is direct and induces translocation of XBP1 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with APPL1 and APPL2 (By similarity). Interacts with SRC (By similarity). Interacts with ALOX5; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (By similarity). Interacts with nephrin NPHN1; the interaction is reduced by high glucose levels (By similarity).
messages: Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR and ERBB4 (By similarity).
messages: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
messages: The SH3 domain mediates the binding to CBLB.

9601:TIMM10B
gene id: 9601:TIMM10B
uniprot id: A0A2J8SVN2
uniprot id: Q5RDJ0
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
messages: Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

9601:CREG1
gene id: 9601:CREG1
uniprot id: A0A6D2WNE9
uniprot id: H2N4V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9601:DOK1
gene id: 9601:DOK1
uniprot id: A0A2J8XB93
uniprot id: H2P5Q6
names: Caution
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRD5A3
gene id: 9601:SRD5A3
uniprot id: H2PDE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9601:FAM46C
gene id: 9601:FAM46C
uniprot id: Q5RE42
names: Similarity
messages: Belongs to the TENT family.

9601:NELL1
gene id: 9601:NELL1
uniprot id: H2NDW2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:DNAJA4
gene id: 9601:DNAJA4
uniprot id: H2NNX9
names: Subcellular Location Annotation
messages: Membrane

9601:GPR89A
gene id: 9601:GPR89A
uniprot id: H2N634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9601:CRISPLD1
gene id: 9601:CRISPLD1
uniprot id: A0A2J8VA13
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VPS11
gene id: 9601:VPS11
uniprot id: A0A2J8X0Q8
uniprot id: A0A6D2X2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9601:TMSB10
gene id: 9601:TMSB10
uniprot id: A0A6D2WQV0
uniprot id: Q5R856
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:ROMO1
gene id: 9601:ROMO1
uniprot id: A0A2J8VJA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100446892
gene id: 9601:LOC100446892
uniprot id: H2NLL5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:ELAVL4
gene id: 9601:ELAVL4
uniprot id: A0A2J8V8E9
uniprot id: A0A2J8V8F8
uniprot id: A0A2J8V8G0
uniprot id: A0A2J8V8G9
uniprot id: A0A663DEY5
uniprot id: H2N7G2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: axon
messages: dendrite
messages: growth cone

9601:ELOVL7
gene id: 9601:ELOVL7
uniprot id: A0A2J8V5I1
uniprot id: A0A6D2XAR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9601:EEF1A1
gene id: 9601:EEF1A1
uniprot id: A0A2J8RYS8
uniprot id: Q5R4R8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
messages: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.
messages: nucleolus

9601:LRIF1
gene id: 9601:LRIF1
uniprot id: A0A2J8UM84
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADGRF1
gene id: 9601:ADGRF1
uniprot id: H2PJ95
names: Subcellular Location Annotation
messages: Membrane

9601:CAPZA3
gene id: 9601:CAPZA3
uniprot id: H2NGR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9601:CITED2
gene id: 9601:CITED2
uniprot id: A0A2J8X9X6
uniprot id: A0A6D2VZU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STX10
gene id: 9601:STX10
uniprot id: A0A2J8RY17
uniprot id: A0A6D2XVC4
uniprot id: H2NXR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCN1A
gene id: 9601:SCN1A
uniprot id: A0A2J8T4U8
uniprot id: A0A2J8T4V7
uniprot id: A0A2J8T4X4
uniprot id: A0A6D2VTH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TLR10
gene id: 9601:TLR10
uniprot id: A0A663D8S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9601:MCM3
gene id: 9601:MCM3
uniprot id: A0A2J8SQ08
uniprot id: Q5R8G6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by MCM3AP.
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (By similarity). Associated with the replication-specific DNA polymerase alpha (By similarity). Interacts with MCMBP. Interacts with ANKRD17. Interacts with MCM3AP isoform MCM3AP; this interaction leads to MCM3 acetylation (By similarity).
messages: Nucleus
messages: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GNG5
gene id: 9601:GNG5
uniprot id: A0A2J8WQH8
uniprot id: Q5REH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMBIM7P
gene id: 9601:TMBIM7P
uniprot id: A0A8I5SYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9601:RPL29
gene id: 9601:RPL29
uniprot id: A0A2J8THE0
uniprot id: A0A6D2VSS9
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACYP1
gene id: 9601:ACYP1
uniprot id: A0A2J8T3S7
uniprot id: A0A2J8T3T2
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCZ1
gene id: 9601:CCZ1
uniprot id: H2PLG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9601:LOC100432873
gene id: 9601:LOC100432873
uniprot id: H2PI94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:VKORC1
gene id: 9601:VKORC1
uniprot id: A0A8I5TB75
uniprot id: H2NQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:KCNA6
gene id: 9601:KCNA6
uniprot id: H2NG68
names: Subcellular Location Annotation
messages: Membrane

9601:PRIM2
gene id: 9601:PRIM2
uniprot id: H2PJG8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

9601:DNAJC10
gene id: 9601:DNAJC10
uniprot id: Q5R5L3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress (By similarity).
messages: Endoplasmic reticulum lumen
messages: Interacts with HSPA5 (via its J domain). Interacts with EDEM1 (By similarity).
messages: The thioredoxin-like regions Trxb 1 and 2 lack a redox-active CXXC motif.
messages: Thioredoxin domains 3 and 4 are the primary reductase domains.

9601:DNASE2B
gene id: 9601:DNASE2B
uniprot id: H2N6X6
names: Similarity
messages: Belongs to the DNase II family.

9601:PHKB
gene id: 9601:PHKB
uniprot id: H2NQT9
uniprot id: Q5R6K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9601:TRIM10
gene id: 9601:TRIM10
uniprot id: A0A2J8SJN0
uniprot id: H2PKZ0
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9601:CPNE3
gene id: 9601:CPNE3
uniprot id: Q5RAE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copine family.
messages: Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1.
messages: Nucleus
messages: Phosphorylated on serine and threonine residues.
messages: focal adhesion

9601:CALCOCO1
gene id: 9601:CALCOCO1
uniprot id: Q5RD60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CALCOCO family.
messages: Cytoplasm
messages: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity).
messages: Nucleus
messages: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (By similarity). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
messages: Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.
messages: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity).
messages: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).
messages: The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).

9601:CDK5RAP3
gene id: 9601:CDK5RAP3
uniprot id: Q5NVI5
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9601:BHMT
gene id: 9601:BHMT
uniprot id: A0A2J8VSZ6
uniprot id: Q5RFG2
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.
messages: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:GAB3
gene id: 9601:GAB3
uniprot id: A0A2J8RMA4
uniprot id: A0A6D2X0I6
uniprot id: H2PXA6
names: Caution
names: Similarity
messages: Belongs to the GAB family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SUDS3
gene id: 9601:SUDS3
uniprot id: A0A2J8XK92
uniprot id: Q5RBB8
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDS3 family.
messages: Interacts with HCFC1. Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct (By similarity). Interacts with FOXK2 (By similarity).
messages: Nucleus
messages: Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity).
messages: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).
messages: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2R2
gene id: 9601:UBE2R2
uniprot id: A0A663DE03
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:CITED1
gene id: 9601:CITED1
uniprot id: A0A2J8R837
uniprot id: A0A2J8R838
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC6A7
gene id: 9601:SLC6A7
uniprot id: H2PH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9601:LOC100435295
gene id: 9601:LOC100435295
uniprot id: A0A6D2XEF4
uniprot id: H2NS27
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9601:AURKA
gene id: 9601:AURKA
uniprot id: A0A6D2WLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9601:GH1
gene id: 9601:GH1
uniprot id: A0A2J8UZP8
uniprot id: A0A2J8UZQ4
uniprot id: H2NUF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL36AL
gene id: 9601:RPL36AL
uniprot id: Q5R9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Cytoplasm

9601:PREB
gene id: 9601:PREB
uniprot id: H2P6Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9601:SFT2D2
gene id: 9601:SFT2D2
uniprot id: H2N4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9601:OSR2
gene id: 9601:OSR2
uniprot id: A0A6D2XYX7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BOLA3
gene id: 9601:BOLA3
uniprot id: A0A6D2WMX8
names: Similarity
messages: Belongs to the BolA/IbaG family.

9601:GNPDA1
gene id: 9601:GNPDA1
uniprot id: A0A6D2WJ25
uniprot id: Q5R8T8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by N-acetylglucosamine-6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
messages: Cytoplasm
messages: Homohexamer.

9601:LOC103888715
gene id: 9601:LOC103888715
uniprot id: A0A2J8RQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SLC50A1
gene id: 9601:SLC50A1
uniprot id: A0A2J8VG67
uniprot id: A0A2J8VG72
uniprot id: A0A2J8VG78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Mediates sugar transport across membranes.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:B3GALNT1
gene id: 9601:B3GALNT1
uniprot id: Q5RAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development.

9601:FAM122A
gene id: 9601:FAM122A
uniprot id: A0A2J8XHE3
names: Similarity
messages: Belongs to the FAM122 family.

9601:FBXO36
gene id: 9601:FBXO36
uniprot id: A0A2J8SHP1
uniprot id: Q5R796
names: Caution
names: Function
names: Subunit
messages: Directly interacts with SKP1 and CUL1.
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RAB38
gene id: 9601:RAB38
uniprot id: H2NEW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9601:ANGEL2
gene id: 9601:ANGEL2
uniprot id: A0A2J8V6A3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VAMP5
gene id: 9601:VAMP5
uniprot id: A0A2J8RP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9601:VPS35
gene id: 9601:VPS35
uniprot id: Q5RDZ3
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9601:RPL37
gene id: 9601:RPL37
uniprot id: A0A663DG97
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9601:DCK
gene id: 9601:DCK
uniprot id: H2PDJ3
names: Similarity
messages: Belongs to the DCK/DGK family.

9601:NUDT17
gene id: 9601:NUDT17
uniprot id: H2N629
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9601:MTMR12
gene id: 9601:MTMR12
uniprot id: Q5R989
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 391 in the dsPTPase catalytic loop and does not have phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Heterodimer with lipid phosphatase MTM1 (By similarity). Heterodimer with lipid phosphatase MTMR2 (By similarity).
messages: Sarcoplasmic reticulum
messages: sarcomere

9601:ETV7
gene id: 9601:ETV7
uniprot id: H2PIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:POLG2
gene id: 9601:POLG2
uniprot id: H2NUG5
names: Subcellular Location Annotation
messages: Mitochondrion

9601:DEGS1
gene id: 9601:DEGS1
uniprot id: Q5RE51
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity).
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Mitochondrion membrane
messages: Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.

9601:ANGPTL6
gene id: 9601:ANGPTL6
uniprot id: A0A6D2VUV2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100434813
gene id: 9601:LOC100434813
uniprot id: H2NDH2
names: Subcellular Location Annotation
messages: Membrane

9601:LASP1
gene id: 9601:LASP1
uniprot id: A0A2J8W9T4
uniprot id: Q5R5W0
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with F-actin (By similarity). Interacts with ANKRD54. Interacts with KBTBD10 (By similarity).
messages: Phosphorylated.
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cell cortex
messages: cytoskeleton

9601:LOC103891543
gene id: 9601:LOC103891543
uniprot id: A0A663DCG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:S100A8
gene id: 9601:S100A8
uniprot id: A0A6D2W9Z0
names: Caution
names: Similarity
messages: Belongs to the S-100 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PISD
gene id: 9601:PISD
uniprot id: A0A2J8UVH1
uniprot id: A0A2J8UVI0
uniprot id: Q5R8I8
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity).
messages: Cytoplasm
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Lipid droplet
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PIGH
gene id: 9601:PIGH
uniprot id: A0A2J8WM59
uniprot id: A0A6D2W1A9
uniprot id: H2NLK5
names: Caution
names: Similarity
messages: Belongs to the PIGH family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UFC1
gene id: 9601:UFC1
uniprot id: A0A2J8VHX6
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9601:FAM53B
gene id: 9601:FAM53B
uniprot id: A0A6D2X9N6
names: Similarity
messages: Belongs to the FAM53 family.

9601:GRWD1
gene id: 9601:GRWD1
uniprot id: H2NZG4
names: Subcellular Location Annotation
messages: Nucleus

9601:FAM167B
gene id: 9601:FAM167B
uniprot id: H2N855
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9601:KATNAL1
gene id: 9601:KATNAL1
uniprot id: A0A663DDA3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9601:KCNE2
gene id: 9601:KCNE2
uniprot id: H2P321
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9601:MRTO4
gene id: 9601:MRTO4
uniprot id: H2N8T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9601:WDR86
gene id: 9601:WDR86
uniprot id: A0A2J8RKF8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:REM1
gene id: 9601:REM1
uniprot id: H2P1J8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9601:C3H3orf58
gene id: 9601:C3H3orf58
uniprot id: H2PBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9601:USP24
gene id: 9601:USP24
uniprot id: H2N795
names: Similarity
messages: Belongs to the peptidase C19 family.

9601:GPR15
gene id: 9601:GPR15
uniprot id: H2P9X8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:MYD88
gene id: 9601:MYD88
uniprot id: H2PB58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.

9601:WDR46
gene id: 9601:WDR46
uniprot id: H2PL55
names: Subcellular Location Annotation
messages: nucleolus

9601:FAT1
gene id: 9601:FAT1
uniprot id: H2PEX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:EYA1
gene id: 9601:EYA1
uniprot id: A0A2J8VA76
uniprot id: A0A2J8VAA0
uniprot id: A0A6D2Y9J6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SST
gene id: 9601:SST
uniprot id: H2PCA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9601:CDC25C
gene id: 9601:CDC25C
uniprot id: A0A2J8VPV2
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9601:ORMDL3
gene id: 9601:ORMDL3
uniprot id: A0A2J8WA39
uniprot id: A0A2J8WA69
uniprot id: K7ETR8
uniprot id: Q5R570
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCNH
gene id: 9601:CCNH
uniprot id: A0A663DBH6
uniprot id: A0A8I5YLM5
uniprot id: H2PG21
uniprot id: Q5R9C8
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9601:SERPINB13
gene id: 9601:SERPINB13
uniprot id: H2NWI0
names: Similarity
messages: Belongs to the serpin family.

9601:CXADR
gene id: 9601:CXADR
uniprot id: Q5R764
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Cell membrane
messages: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity).
messages: Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form) (By similarity).
messages: N-glycosylated.
messages: Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
messages: The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.
messages: The PDZ-binding motif mediates interaction with MPDZ and MAGI1.
messages: adherens junction
messages: tight junction

9601:LOC100443047
gene id: 9601:LOC100443047
uniprot id: A0A2J8UKQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100438976
gene id: 9601:LOC100438976
uniprot id: A0A6D2WSS2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:XPO7
gene id: 9601:XPO7
uniprot id: Q5R9G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exportin family.
messages: Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity).
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Nucleus
messages: nuclear pore complex

9601:ZNF180
gene id: 9601:ZNF180
uniprot id: A0A2J8RTL2
uniprot id: A0A2J8RTL9
uniprot id: Q5R9V8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ELF5
gene id: 9601:ELF5
uniprot id: A0A2J8WFZ0
uniprot id: A0A2J8WFZ4
uniprot id: A0A2J8WG19
uniprot id: H2NDQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZFYVE26
gene id: 9601:ZFYVE26
uniprot id: H2NLL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9601:AQP1
gene id: 9601:AQP1
uniprot id: Q5R819
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Homotetramer (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear. Identified in a complex with STOM (By similarity).
messages: Pharmacologically inhibited by submillimolar concentrations of mercury.

9601:PPME1
gene id: 9601:PPME1
uniprot id: Q5R4F9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).
messages: Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.

9601:RIT1
gene id: 9601:RIT1
uniprot id: A0A663DIB8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GTF2H4
gene id: 9601:GTF2H4
uniprot id: A0A6D2X0M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9601:RNF146
gene id: 9601:RNF146
uniprot id: A0A2J8X8T8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9601:POLD4
gene id: 9601:POLD4
uniprot id: A0A6D2W3W9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRP19
gene id: 9601:SRP19
uniprot id: A0A140TAX6
uniprot id: Q5RBR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with IPO8 and TNPO1 may be involved in SRP19 import into the nucleus (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity).
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9601:NEDD4L
gene id: 9601:NEDD4L
uniprot id: A0A2J8W373
uniprot id: Q5RBF2
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by NDFIP1- and NDFIP2-binding.
messages: Auto-ubiquitinated.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes (By similarity). Involved in the regulation of TOR signaling (By similarity).
messages: Golgi apparatus
messages: Interacts with UBE2E3 (By similarity). Interacts with NDFIP1; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts with NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts (via WW domains) with SCNN1A (By similarity). Interacts (via WW domains) with SCNN1B (By similarity). Interacts (via WW domains) with SCNN1G (By similarity). Interacts (via WW domains) with SCN1A (By similarity). Interacts (via WW domains) with SCN2A (By similarity). Interacts (via WW domains) with SCN3A (By similarity). Interacts (via WW domains) with SCN5A (By similarity). Interacts (via WW domains) with SCN8A (By similarity). Interacts (via WW domains) with SCN9A (By similarity). Interacts (via WW domains) with SCN10A (By similarity). Interacts (via WW domains) with CLCN5 (By similarity). Interacts with SMAD2 (By similarity). Interacts with SMAD3 (By similarity). Interacts with SMAD6 (By similarity). Interacts with SMAD7 (By similarity). The phosphorylated form interacts with 14-3-3 proteins (By similarity). Interacts with TNK2 (By similarity). Interacts with WNK1 (By similarity). Interacts with SGK1 (By similarity). Interacts (via C2 domain) with NPC2 (By similarity). Interacts with ARRDC4 (By similarity). Interacts with KCNQ1; promotes internalization of KCNQ1 (By similarity). Interacts (via domains WW1, 3 and 4) with USP36; the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (By similarity). Interacts with LDLRAD3; the interaction is direct (By similarity).
messages: Phosphorylated; which impairs interaction with SCNN. Interaction with YWHAH inhibits dephosphorylation (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: multivesicular body

9601:FOXP3
gene id: 9601:FOXP3
uniprot id: A0A2J8R889
uniprot id: A0A663DC87
uniprot id: H2PVM2
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPRY2
gene id: 9601:SPRY2
uniprot id: Q5R959
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity).
messages: Belongs to the sprouty family.
messages: Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
messages: Forms heterodimers with SPRY1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (By similarity). Within the complex interacts with METTL13 (By similarity). Interacts with RAF1 (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation (By similarity). Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2 (By similarity). Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2 (By similarity). Interacts with GRB2 (By similarity). Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR (By similarity). Interacts (via C-terminus) with CAV1 (via C-terminus) (By similarity).
messages: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
messages: cytoskeleton
messages: ruffle membrane

9601:LOC100431931
gene id: 9601:LOC100431931
uniprot id: H2NHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CORO1B
gene id: 9601:CORO1B
uniprot id: Q5NVK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).
messages: Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity).
messages: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
messages: cytoskeleton
messages: stress fiber

9601:DKK4
gene id: 9601:DKK4
uniprot id: H2PQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9601:MRPL9
gene id: 9601:MRPL9
uniprot id: A0A2J8VF84
uniprot id: H2N5U6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9601:SKA1
gene id: 9601:SKA1
uniprot id: A0A6D2Y2S8
names: Similarity
messages: Belongs to the SKA1 family.

9601:LOC100445619
gene id: 9601:LOC100445619
uniprot id: A0A6D2W083
names: Subcellular Location Annotation
messages: Membrane

9601:ZNF266
gene id: 9601:ZNF266
uniprot id: H2NXG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LRRC42
gene id: 9601:LRRC42
uniprot id: A0A6D2VUI2
names: Similarity
messages: Belongs to the LRRC42 family.

9601:CSE1L
gene id: 9601:CSE1L
uniprot id: Q5R9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm
messages: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
messages: Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1. Interacts with CFTR.
messages: Nucleus

9601:ZNF23
gene id: 9601:ZNF23
uniprot id: A0A2J8VW06
uniprot id: H2NRF3
uniprot id: Q5RF55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CASC1
gene id: 9601:CASC1
uniprot id: Q5RDT4
names: Similarity
messages: Belongs to the DNAI7 family.

9601:MRPL15
gene id: 9601:MRPL15
uniprot id: H2PQB3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9601:FAHD2A
gene id: 9601:FAHD2A
uniprot id: Q5RCX5
names: Function
names: Similarity
messages: Belongs to the FAH family.
messages: May have hydrolase activity.

9601:TLR6
gene id: 9601:TLR6
uniprot id: A0A6D2XY24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:APCS
gene id: 9601:APCS
uniprot id: H2N570
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9601:MGAT4C
gene id: 9601:MGAT4C
uniprot id: A0A6D2WDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:MALSU1
gene id: 9601:MALSU1
uniprot id: H2PMN3
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9601:PPP2R5A
gene id: 9601:PPP2R5A
uniprot id: H2N3S2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9601:ASPH
gene id: 9601:ASPH
uniprot id: A0A803KLC7
uniprot id: Q5RDP7
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EML4
gene id: 9601:EML4
uniprot id: A0A663DJ65
uniprot id: H2P6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9601:DSP
gene id: 9601:DSP
uniprot id: H2PHV5
names: Subcellular Location Annotation
messages: cytoskeleton

9601:RXRB
gene id: 9601:RXRB
uniprot id: A0A6D2XGY8
uniprot id: H2PL46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TNFSF13B
gene id: 9601:TNFSF13B
uniprot id: A0A8I5YPM7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9601:DDB2
gene id: 9601:DDB2
uniprot id: A0A2J8WF03
uniprot id: H2NDJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9601:BCL11A
gene id: 9601:BCL11A
uniprot id: A0A2J8XCJ1
uniprot id: A0A663DF80
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ANXA9
gene id: 9601:ANXA9
uniprot id: H2N5X6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9601:TOX4
gene id: 9601:TOX4
uniprot id: Q5R6A9
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity). Interacts with FOXO1 and CREB1 (increased by cAMP); FOXO1 and CREB1 are required for full induction of TOX4-dependent activity and the interactions are inhibited by insulin (By similarity).
messages: In liver, recruited to target gene promoters following treatment with dexamethasone and cAMP. Binding is decreased in presence of insulin.
messages: Nucleus
messages: Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (By similarity).

9601:GJC1
gene id: 9601:GJC1
uniprot id: A0A2J8UYM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:ENTPD7
gene id: 9601:ENTPD7
uniprot id: Q5REF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleoside diphosphates only to a minor extent.
messages: Cytoplasmic vesicle membrane

9601:MYL5
gene id: 9601:MYL5
uniprot id: A0A2J8SSF7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HNRNPF
gene id: 9601:HNRNPF
uniprot id: A0A2J8XT95
names: Subcellular Location Annotation
messages: nucleoplasm

9601:UGT2A3
gene id: 9601:UGT2A3
uniprot id: Q5RFJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane
messages: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

9601:AP2A2
gene id: 9601:AP2A2
uniprot id: Q5RDM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9601:GJA10
gene id: 9601:GJA10
uniprot id: A0A654ICP8
uniprot id: H2PJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:KCNB1
gene id: 9601:KCNB1
uniprot id: A0A6D2XQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9601:CSTF2T
gene id: 9601:CSTF2T
uniprot id: H2NAW1
names: Subcellular Location Annotation
messages: Nucleus

9601:GSTO1
gene id: 9601:GSTO1
uniprot id: H2NBI9
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9601:FZD6
gene id: 9601:FZD6
uniprot id: A0A2J8UFN4
uniprot id: Q5RCN4
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with LMBR1L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

9601:HTATSF1
gene id: 9601:HTATSF1
uniprot id: A0A2J8WX75
uniprot id: Q5RB63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HTATSF1 family.
messages: Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs) (By similarity).
messages: Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity).
messages: Nucleus
messages: The RRM domains mediate interaction with U snRNPs.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP6V1G3
gene id: 9601:ATP6V1G3
uniprot id: A0A6D2XSX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9601:INHBA
gene id: 9601:INHBA
uniprot id: A0A6D2XF55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9601:LECT2
gene id: 9601:LECT2
uniprot id: A0A6D2XWV6
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9601:ACOX2
gene id: 9601:ACOX2
uniprot id: Q5R8P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9601:TRUB1
gene id: 9601:TRUB1
uniprot id: H2NBP6
uniprot id: Q5RCS1
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9601:KDELR1
gene id: 9601:KDELR1
uniprot id: A0A663DA43
uniprot id: H2NZG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:LOC100440065
gene id: 9601:LOC100440065
uniprot id: H2PF89
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9601:RXFP1
gene id: 9601:RXFP1
uniprot id: Q5R5V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C1QTNF8.
messages: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).

9601:B4GALT6
gene id: 9601:B4GALT6
uniprot id: A0A2J8XFY1
uniprot id: H2NW49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9601:KLHL33
gene id: 9601:KLHL33
uniprot id: A0A2J8TSZ7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMPRSS3
gene id: 9601:TMPRSS3
uniprot id: Q5RDX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:SLC41A1
gene id: 9601:SLC41A1
uniprot id: A0A2J8V6Y4
uniprot id: Q5R839
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Basolateral cell membrane
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Membrane
messages: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).
messages: Phosphorylated.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GOLGA7
gene id: 9601:GOLGA7
uniprot id: A0A2J8TNU7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NDRG2
gene id: 9601:NDRG2
uniprot id: A0A2J8TSN8
uniprot id: A0A2J8TSR1
uniprot id: Q5RBN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: Interacts with CTNNB1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: growth cone
messages: perinuclear region

9601:MYCL
gene id: 9601:MYCL
uniprot id: A0A2J8Y684
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9601:GNGT2
gene id: 9601:GNGT2
uniprot id: A0A6D2XBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9601:PPTC7
gene id: 9601:PPTC7
uniprot id: A0A6D2W0I4
names: Similarity
messages: Belongs to the PP2C family.

9601:CRABP1
gene id: 9601:CRABP1
uniprot id: H2NNY1
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

9601:OXSM
gene id: 9601:OXSM
uniprot id: H2PBB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9601:ZNF683
gene id: 9601:ZNF683
uniprot id: A0A2J8SIH1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCNDBP1
gene id: 9601:CCNDBP1
uniprot id: A0A2J8S5E5
uniprot id: Q5RFN4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Cytoplasm
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
messages: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGF16
gene id: 9601:FGF16
uniprot id: H2PW31
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9601:SCIN
gene id: 9601:SCIN
uniprot id: H2PMT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9601:NBN
gene id: 9601:NBN
uniprot id: E5FGN4
uniprot id: Q5RCV3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (By similarity).
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (By similarity). As part of the MRN complex, interacts with MCM9; the interaction recruits the complex to DNA repair sites (By similarity). Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (By similarity). Interacts with histone H2AX this requires phosphorylation of H2AX on 'Ser-139' (By similarity). Interacts with HJURP, INTS3, KPNA2 and TERF2 (By similarity). Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection (By similarity). Interacts with SP100; recruits NBN to PML bodies (By similarity). Interacts with ATF2 (By similarity). Interacts with MTOR, MAPKAP1 isoform 2 and RICTOR; indicative for an association with the mTORC2 complex (By similarity). Interacts with MRNIP (By similarity). Interacts with UFL1; promoting UFL1 recruitment to double-strand breaks following DNA damage (By similarity). Interacts with CYREN (via XLF motif) (By similarity).
messages: Component of the MRN complex.
messages: Nucleus
messages: PML body
messages: Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.
messages: The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex. Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection (By similarity).
messages: The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response.
messages: The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage.
messages: telomere

9601:SMAD7
gene id: 9601:SMAD7
uniprot id: H2NWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9601:LOC100452361
gene id: 9601:LOC100452361
uniprot id: H2PXE2
names: Similarity
messages: Belongs to the histone H2B family.

9601:RNF219
gene id: 9601:RNF219
uniprot id: A0A2J8WU87
uniprot id: Q5RD97
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ORC complex. Binds to chromatin; association is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase.
messages: Auto-ubiquitinated.
messages: Chromosome
messages: E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PCOLCE
gene id: 9601:PCOLCE
uniprot id: H2PLP1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:ACMSD
gene id: 9601:ACMSD
uniprot id: A0A2J8T216
uniprot id: H2P7F0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9601:CASP1
gene id: 9601:CASP1
uniprot id: A0A2J8XXB5
uniprot id: A0A6D2WB84
names: Similarity
messages: Belongs to the peptidase C14A family.

9601:RFFL
gene id: 9601:RFFL
uniprot id: H2NTC3
names: Subcellular Location Annotation
messages: Cell membrane

9601:TFPI
gene id: 9601:TFPI
uniprot id: Q5RF98
names: Subcellular Location Annotation
messages: Secreted

9601:MIEF1
gene id: 9601:MIEF1
uniprot id: Q5RBN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MID49/MID51 family.
messages: Homodimer. Interacts with DNM1L (By similarity).
messages: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L (By similarity).
messages: Mitochondrion outer membrane

9601:LOC100437391
gene id: 9601:LOC100437391
uniprot id: A0A2J8RUF6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:SNAP25
gene id: 9601:SNAP25
uniprot id: A0A2J8SU12
uniprot id: Q5NVG5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8 (By similarity). Interacts with HSC70 and with SYT9, forming a complex with DNAJC5 (By similarity). The interaction with SYT9 is inhibited in presence of calcium (By similarity). Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex (By similarity). Interacts with HSC70 and with SYT9, forming a complex with DNAJC5 (By similarity). The interaction with SYT9 is inhibited in presence of calcium (By similarity). Interacts with PLCL1 (via C2 domain) (By similarity). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with PRPH2 (By similarity). Interacts with ROM1 (By similarity). Interacts with STX3 (By similarity).
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9601:RPRD1A
gene id: 9601:RPRD1A
uniprot id: A0A2J8XFG6
uniprot id: Q5R8Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.
messages: May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NOP10
gene id: 9601:NOP10
uniprot id: H2NMQ8
names: Similarity
messages: Belongs to the NOP10 family.

9601:CAV3
gene id: 9601:CAV3
uniprot id: A0A2J8WDX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: caveola
messages: sarcolemma

9601:SRF
gene id: 9601:SRF
uniprot id: H2PJ46
names: Subcellular Location Annotation
messages: Nucleus

9601:CNTNAP2
gene id: 9601:CNTNAP2
uniprot id: Q5RD64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neurexin family.
messages: Interacts (via C-terminus) with KCNA2.
messages: Membrane
messages: Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.
messages: axon
messages: paranodal septate junction

9601:VCAM1
gene id: 9601:VCAM1
uniprot id: Q5R847
names: Subcellular Location Annotation
messages: Cell membrane

9601:CACNG3
gene id: 9601:CACNG3
uniprot id: A0A2J8TJG1
uniprot id: Q5R572
uniprot id: Q5R5X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
messages: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TGM2
gene id: 9601:TGM2
uniprot id: H2P1W1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:SPACA4
gene id: 9601:SPACA4
uniprot id: H2NZH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9601:NTS
gene id: 9601:NTS
uniprot id: H2NI71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9601:CHCHD10
gene id: 9601:CHCHD10
uniprot id: A0A6D2Y8G4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VSNL1
gene id: 9601:VSNL1
uniprot id: Q5RD22
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: Probably binds three calcium ions.
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9601:IL17B
gene id: 9601:IL17B
uniprot id: H2PH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9601:MANBA
gene id: 9601:MANBA
uniprot id: Q5RDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9601:NDUFA6
gene id: 9601:NDUFA6
uniprot id: A0A6D2WGB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:PYGL
gene id: 9601:PYGL
uniprot id: A0A6D2X5L5
uniprot id: H2NL84
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9601:ROM1
gene id: 9601:ROM1
uniprot id: H2ND54
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9601:UQCC
gene id: 9601:UQCC
uniprot id: H2P1R5
uniprot id: Q5R9F6
names: Similarity
messages: Belongs to the CBP3 family.

9601:IVD
gene id: 9601:IVD
uniprot id: Q5RBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
messages: Homotetramer.
messages: Mitochondrion matrix

9601:MZT1
gene id: 9601:MZT1
uniprot id: H2NK14
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9601:NQO1
gene id: 9601:NQO1
uniprot id: A0A2J8VVT1
uniprot id: Q5RD31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.
messages: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
messages: Homodimer. Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome. Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:TUBD1
gene id: 9601:TUBD1
uniprot id: A0A2J8W7H8
uniprot id: A0A6D2YAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9601:GSKIP
gene id: 9601:GSKIP
uniprot id: A0A6D2WRT5
names: Similarity
messages: Belongs to the GSKIP family.

9601:TXNL1
gene id: 9601:TXNL1
uniprot id: A0A6D2W4B7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CTSC
gene id: 9601:CTSC
uniprot id: A0A2J8S672
uniprot id: Q5RB02
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity).

9601:CGAS
gene id: 9601:CGAS
uniprot id: A0A6D2WSG3
uniprot id: H2PJL0
names: Similarity
messages: Belongs to the mab-21 family.

9601:EXOSC1
gene id: 9601:EXOSC1
uniprot id: A0A6D2XD67
names: Subcellular Location Annotation
messages: Cytoplasm

9601:ZNF614
gene id: 9601:ZNF614
uniprot id: Q5RCJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:C12H12orf54
gene id: 9601:C12H12orf54
uniprot id: A0A6D2Y460
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHRM4
gene id: 9601:CHRM4
uniprot id: K7EUB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9601:CHD1L
gene id: 9601:CHD1L
uniprot id: A0A2J8XT10
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STC2
gene id: 9601:STC2
uniprot id: Q5RAT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
messages: Homodimer; disulfide-linked.
messages: Secreted

9601:NDUFS5
gene id: 9601:NDUFS5
uniprot id: A0A2J8Y6G7
uniprot id: P0CB87
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM200A
gene id: 9601:TMEM200A
uniprot id: A0A6D2W447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9601:ECHDC1
gene id: 9601:ECHDC1
uniprot id: A0A2J8X8T9
uniprot id: Q5R4W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:PIPOX
gene id: 9601:PIPOX
uniprot id: Q5R9T7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9601:CADM3
gene id: 9601:CADM3
uniprot id: A0A2J8VHD1
uniprot id: H2N577
names: Similarity
messages: Belongs to the nectin family.

9601:TNNI3
gene id: 9601:TNNI3
uniprot id: Q5R7Y9
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9601:IFNA2
gene id: 9601:IFNA2
uniprot id: A0A663DA02
uniprot id: H2PS17
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPATA20
gene id: 9601:SPATA20
uniprot id: A0A2J8W8I4
uniprot id: A0A2J8W8I5
uniprot id: A0A2J8W8J1
uniprot id: H2NTM9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNN2
gene id: 9601:KCNN2
uniprot id: Q5RD92
names: Subcellular Location Annotation
messages: Membrane

9601:CYP1A2
gene id: 9601:CYP1A2
uniprot id: Q5RBQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
messages: Microsome membrane

9601:GANAB
gene id: 9601:GANAB
uniprot id: A0A2J8TXV9
uniprot id: H2ND53
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9601:TYW1
gene id: 9601:TYW1
uniprot id: A0A2J8T1X6
uniprot id: Q5REF9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNW1
gene id: 9601:SNW1
uniprot id: Q5R7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5 tri-snRNPs). Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4. Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2. Interacts with MAML1. Interacts with NOTCH1 NICD; the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is dissociated by RBPJ. Associates with positive transcription elongation factor b (P-TEFb). Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
messages: Nucleus

9601:SERPINI1
gene id: 9601:SERPINI1
uniprot id: A0A6D2Y0B6
names: Similarity
messages: Belongs to the serpin family.

9601:ALG8
gene id: 9601:ALG8
uniprot id: A0A2J8V0P2
uniprot id: A0A6D2X965
uniprot id: A0A8I5U5B9
uniprot id: Q5R917
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DNAJC24
gene id: 9601:DNAJC24
uniprot id: A0A6D2XBT8
names: Caution
names: Similarity
messages: Belongs to the DPH4 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TGM4
gene id: 9601:TGM4
uniprot id: B4YUQ9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:CDH13
gene id: 9601:CDH13
uniprot id: Q5R5W6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth (By similarity).
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9601:TMSB15A
gene id: 9601:TMSB15A
uniprot id: A0A663DCM1
uniprot id: H2PXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9601:SLC35A1
gene id: 9601:SLC35A1
uniprot id: Q5RAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9601:LOC100439869
gene id: 9601:LOC100439869
uniprot id: A0A2J8R7L3
uniprot id: H2NJB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9601:FSHB
gene id: 9601:FSHB
uniprot id: H2NDT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9601:PIGM
gene id: 9601:PIGM
uniprot id: Q5RAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).

9601:ZNF24
gene id: 9601:ZNF24
uniprot id: A0A2J8XFL7
uniprot id: Q5RAE6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Sumoylated.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity).

9601:LOC100453263
gene id: 9601:LOC100453263
uniprot id: H2N6H1
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9601:PHOSPHO1
gene id: 9601:PHOSPHO1
uniprot id: A0A2J8W8Z6
uniprot id: A0A663DBM2
uniprot id: H2NVK5
names: Caution
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CBR1
gene id: 9601:CBR1
uniprot id: Q5RCU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.
messages: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).

9601:PDE1C
gene id: 9601:PDE1C
uniprot id: Q5RDH9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9601:SCAMP1
gene id: 9601:SCAMP1
uniprot id: A0A2J8VT18
uniprot id: Q5R647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9601:TPST1
gene id: 9601:TPST1
uniprot id: H2PM04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9601:RDH14
gene id: 9601:RDH14
uniprot id: A0A8I5TNT2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:KIAA0895
gene id: 9601:KIAA0895
uniprot id: A0A2J8UNP0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHST5
gene id: 9601:CHST5
uniprot id: H2NRI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9601:KCNK1
gene id: 9601:KCNK1
uniprot id: Q5RD07
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Homodimer; disulfide-linked (By similarity). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (By similarity). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (By similarity).
messages: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels, and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling end…
messages: Perikaryon
messages: Recycling endosome
messages: Sumoylation is controversial. Sumoylated by UBE2I. Not sumoylated when expressed in xenopus oocytes or mammalian cells. Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane. Sumoylation of a single subunit is sufficient to silence the dimeric channel. Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9. Desumoylated by SENP1; this activates the channel. Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9. SENP1 treatment has no effect.
messages: Synaptic cell membrane
messages: dendrite

9601:B4GALT1
gene id: 9601:B4GALT1
uniprot id: H2PRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9601:NIF3L1
gene id: 9601:NIF3L1
uniprot id: A0A6D2XZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9601:SPA17
gene id: 9601:SPA17
uniprot id: A0A6D2X3P2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPA1
gene id: 9601:CPA1
uniprot id: H2PNI7
names: Similarity
messages: Belongs to the peptidase M14 family.

9601:NAA15
gene id: 9601:NAA15
uniprot id: Q5R4J9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (By similarity).
messages: Cleaved by caspases during apoptosis.
messages: Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15 (By similarity). Interacts with XRCC6, NAA50 and XRCC5 (By similarity). Associates with HYPK when in a complex with NAA10 (By similarity). Interaction with HYPK reduces the capacity to interact with NAA50 (By similarity).
messages: Cytoplasm
messages: Nucleus

9601:CD82
gene id: 9601:CD82
uniprot id: H2NDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9601:FAM168A
gene id: 9601:FAM168A
uniprot id: A0A2J8V1L4
uniprot id: H2NEL4
names: Similarity
messages: Belongs to the FAM168 family.

9601:ANGPT2
gene id: 9601:ANGPT2
uniprot id: A0A6D2XQT4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PMPCB
gene id: 9601:PMPCB
uniprot id: Q5REK3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binding to PMPCA is required for catalytic activity.
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity).
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9601:TLR3
gene id: 9601:TLR3
uniprot id: H2PEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9601:LOC100433032
gene id: 9601:LOC100433032
uniprot id: H2NMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GM2A
gene id: 9601:GM2A
uniprot id: A0A6D2YCL8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GDPD3
gene id: 9601:GDPD3
uniprot id: H2NQK0
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9601:ANAPC2
gene id: 9601:ANAPC2
uniprot id: H2PU30
names: Similarity
messages: Belongs to the cullin family.

9601:KRT18
gene id: 9601:KRT18
uniprot id: A0A6D2XVQ7
names: Similarity
messages: Belongs to the intermediate filament family.

9601:CSRP1
gene id: 9601:CSRP1
uniprot id: Q5RCT4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Could play a role in neuronal development.
messages: Interacts with ASCC1; ASCC2 and TRIP4.
messages: Nucleus

9601:ATP5MD
gene id: 9601:ATP5MD
uniprot id: A0A6D2WW04
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PON2
gene id: 9601:PON2
uniprot id: H2PMW0
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9601:GHRL
gene id: 9601:GHRL
uniprot id: A0A2J8WDI1
uniprot id: A0A6D2X004
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPPED2
gene id: 9601:MPPED2
uniprot id: A0A2J8WGM3
uniprot id: Q5REB1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0046 family.
messages: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
messages: Homodimer.
messages: Inhibited by nmolar levels of AMP and GMP.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100447258
gene id: 9601:LOC100447258
uniprot id: H2N7D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9601:TM4SF1
gene id: 9601:TM4SF1
uniprot id: Q5RE43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the L6 tetraspanin family.
messages: Membrane
messages: Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (By similarity).

9601:ZWINT
gene id: 9601:ZWINT
uniprot id: A0A2J8WQV0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COQ9
gene id: 9601:COQ9
uniprot id: H2NR05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9601:TKT
gene id: 9601:TKT
uniprot id: Q5R4C1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

9601:LPAR5
gene id: 9601:LPAR5
uniprot id: H2NG89
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:RNF41
gene id: 9601:RNF41
uniprot id: A0A2J8UHP9
uniprot id: A0A2J8UHQ7
uniprot id: Q5R7T5
names: Caution
names: Function
names: PTM
names: Subunit
messages: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
messages: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
messages: Interacts with USP8, ERBB3, PRKN, BIRC6, CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with CLEC16A.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100434694
gene id: 9601:LOC100434694
uniprot id: A0A2J8SVE7
uniprot id: A0A6D2WK87
names: Caution
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ESS2
gene id: 9601:ESS2
uniprot id: H2P3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9601:UBE2F
gene id: 9601:UBE2F
uniprot id: A0A2J8TPI6
uniprot id: A0A6D2XW75
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:YIPF6
gene id: 9601:YIPF6
uniprot id: A0A663DFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9601:VASN
gene id: 9601:VASN
uniprot id: H2NQ05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:REXO2
gene id: 9601:REXO2
uniprot id: A0A6D2YCP1
names: Similarity
messages: Belongs to the oligoribonuclease family.

9601:TMEM254
gene id: 9601:TMEM254
uniprot id: Q5R9A6
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100452448
gene id: 9601:LOC100452448
uniprot id: H2PHS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9601:POLE3
gene id: 9601:POLE3
uniprot id: A0A2J8WRX2
uniprot id: Q5R4W3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).
messages: Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Heterodimer with CHRAC1; binds to DNA (By similarity). Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity (By similarity). Within the complex, the heterodimer with CHRAC1 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (By similarity). Within the complex, the heterodimer with CHRAC1 interacts with BAZ1A/ACF1; the interactions are direct (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GALE
gene id: 9601:GALE
uniprot id: Q5R8D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9601:DHRS4
gene id: 9601:DHRS4
uniprot id: A0A2J8TRK8
uniprot id: Q5RCF8
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Homotetramer.
messages: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals. In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds.
messages: Peroxisome
messages: Primate DHRS4s display different stereoselectivity and catalytic efficiency in the oxidoreduction of some substrates as compared to other mammal DHRS4s due to a difference in conserved amino acid residues.
messages: The C-terminus peroxisomal targeting signal tripeptide is important for peroxisomal import. Once in the peroxisome, it is involved in intersubunit interactions.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Three specific residues, Ser-176, Phe-179 and Thr-195 are conserved between primates whereas the respective residues are phenylalanine, leucine, and asparagine in the other mammal enzymes. The two residues at positions 176 and 179 are molecular determinants responsible for the stereoselective reduction of 3-ketosteroids and benzil. The presence of an asparagine at position 195 is important for the maintenance of the quaternary structure and stability at cold temperature. The absence of an asparagine at position 195 destabilizes the quaternary structure, thereby affecting catalytic efficiency toward some substrates and decreasing stability at cold temperature.

9601:TMX2
gene id: 9601:TMX2
uniprot id: Q5RF53
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Occurs in both reduced and oxidized monomeric form (By similarity). Oxidative conditions increase homodimerization (By similarity). Interacts with CANX (By similarity). Interacts with ATP2A2 (By similarity).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

9601:FAM229A
gene id: 9601:FAM229A
uniprot id: A0A2J8Y775
names: Caution
names: Similarity
messages: Belongs to the FAM229 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNE5
gene id: 9601:KCNE5
uniprot id: H2PWH0
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9601:LOC100445409
gene id: 9601:LOC100445409
uniprot id: A0A2J8S9B3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEMG2
gene id: 9601:SEMG2
uniprot id: A0A2J8XVT5
uniprot id: P0C7A4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the semenogelin family.
messages: Interacts with SERPINA5.
messages: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HDAC2
gene id: 9601:HDAC2
uniprot id: Q5R6R9
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

9601:DCT
gene id: 9601:DCT
uniprot id: A0A2J8X8R4
uniprot id: H2NK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9601:TRAPPC3
gene id: 9601:TRAPPC3
uniprot id: A0A2J8Y6S0
uniprot id: A0A6D2VW23
uniprot id: H2N801
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cis-Golgi network

9601:RAD21
gene id: 9601:RAD21
uniprot id: A0A6D2XLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9601:GCFC2
gene id: 9601:GCFC2
uniprot id: H2P5P7
names: Similarity
messages: Belongs to the GCF family.

9601:TRMT13
gene id: 9601:TRMT13
uniprot id: H2N6N3
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9601:PBLD
gene id: 9601:PBLD
uniprot id: Q5RDZ1
names: Similarity
names: Subunit
messages: Belongs to the PhzF family.
messages: Interacts with UNRIP/MAWD.

9601:SEPHS1
gene id: 9601:SEPHS1
uniprot id: A0A2J8VKH4
uniprot id: Q5RF87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class II subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Cell membrane
messages: Homodimer.
messages: Nucleus membrane
messages: Synthesizes selenophosphate from selenide and ATP.
messages: The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GIMAP7
gene id: 9601:GIMAP7
uniprot id: H2PP08
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9601:LOC100440158
gene id: 9601:LOC100440158
uniprot id: A0A8I5TWZ1
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9601:GPR3
gene id: 9601:GPR3
uniprot id: H2N8D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:AFG3L2
gene id: 9601:AFG3L2
uniprot id: H2NVT2
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9601:VAX1
gene id: 9601:VAX1
uniprot id: H2NBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9601:ZNF221
gene id: 9601:ZNF221
uniprot id: A0A2J8RTG3
uniprot id: A0A6D2XP20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:ECEL1
gene id: 9601:ECEL1
uniprot id: A0A2J8TQ70
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPIF
gene id: 9601:PPIF
uniprot id: H2NAG4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:LSM12
gene id: 9601:LSM12
uniprot id: A0A2J8UYA5
uniprot id: Q5RAT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LSM12 family.
messages: Cytoplasm
messages: Found in a complex with LSM12, TPCN1 and TPCN2. Interacts with TPCN2.
messages: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein. Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPXM2
gene id: 9601:CPXM2
uniprot id: H2NBW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9601:FAM118A
gene id: 9601:FAM118A
uniprot id: A0A6D2WA11
names: Similarity
messages: Belongs to the FAM118 family.

9601:GNG4
gene id: 9601:GNG4
uniprot id: A0A2J8UE19
uniprot id: Q5R639
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Interacts with KCNK1 (By similarity).
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WNK1
gene id: 9601:WNK1
uniprot id: A0A2J8S3N8
uniprot id: A0A8I5TFT6
uniprot id: A0A8I5UAU4
uniprot id: H2NG28
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9601:MPHOSPH10
gene id: 9601:MPHOSPH10
uniprot id: H2P5W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9601:HMGCR
gene id: 9601:HMGCR
uniprot id: Q5R6N3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMG-CoA reductase family.
messages: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
messages: Endoplasmic reticulum membrane
messages: Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
messages: N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
messages: Peroxisome membrane
messages: Phosphorylated. Phosphorylation at Ser-872 reduces the catalytic activity.
messages: Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate (By similarity). Phosphorylation at Ser-872 down-regulates the catalytic activity (By similarity).
messages: Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1 or INSIG2. The INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, RNF139 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. The INSIG2-binding leads to the recruitment of the ubiquitin ligase RNF139, initiating ubiquitination of the reductase. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

9601:LOC100435013
gene id: 9601:LOC100435013
uniprot id: H2PMJ0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:PMP22
gene id: 9601:PMP22
uniprot id: A0A2J8TF29
uniprot id: Q5RAZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WASHC1
gene id: 9601:WASHC1
uniprot id: H2P7E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9601:B3GNT5
gene id: 9601:B3GNT5
uniprot id: A0A6D2XMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:LOC103890529
gene id: 9601:LOC103890529
uniprot id: A0A2J8V7W0
uniprot id: A0A6D2VZE7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ABI2
gene id: 9601:ABI2
uniprot id: Q5RE24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9601:REEP2
gene id: 9601:REEP2
uniprot id: H2PGP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:DUSP4
gene id: 9601:DUSP4
uniprot id: H2PPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9601:TRMT11
gene id: 9601:TRMT11
uniprot id: Q5R962
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9601:RAD54L2
gene id: 9601:RAD54L2
uniprot id: H2PAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9601:PDHA2
gene id: 9601:PDHA2
uniprot id: H2PDX7
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9601:LCE1D
gene id: 9601:LCE1D
uniprot id: A0A2J8VFF7
names: Similarity
messages: Belongs to the LCE family.

9601:GORAB
gene id: 9601:GORAB
uniprot id: H2N4R5
names: Similarity
messages: Belongs to the GORAB family.

9601:DHX9
gene id: 9601:DHX9
uniprot id: A0A2J8V836
uniprot id: Q5R874
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (By similarity). Associates (via DRBM domains) with the RISC complex; this association occurs in a small interfering (siRNA)-dependent manner. Associates with the SMN complex; this association induces recruitment of DHX9 to the RNA polymerase II. Associates with polysomes in a LIN28A-dependent manner. Interacts (via C-terminus) with ACTB; this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with ADAR isoform 1; this interaction occurs in a RNA-independent manner. Interacts (via DRBM domains) with AGO2 (via middle region); this interaction promotes active RISC assembly by promoting the association of siRNA with AGO2. Interacts (via NTD domain) with AKAP8L (via N-terminus). Interacts with BRCA1 (via C-terminus); this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme. Interacts (via N-terminus) with CREBBP; this interaction mediates association with RNA polymerase II holoenzyme and stimulates CREB-dependent transcriptional activation. Interacts (via N-terminus) with EIF2AK2/PKR; this interaction is dependent upon the activation of the kinase. Interacts (via DRBM domains) with DICER1. Interacts with H2AX; this interaction is direct, requires phosphorylation of histone H2AX by PRKDC and promotes binding of DHX9 to transcriptionally stalled sites on chromosomal DNA in response to genotoxic stress. Interacts with HNRNPC; this interaction is direct, enhanced probably by their concomit…
messages: Cytoplasm
messages: DRBM domains cooperate for the binding to nucleic acid but not for unwinding helicase activity. The helicase-associated domain-2 (HA2) region is essential for the duplex RNA unwinding helicase activity. The minimal transactivation region (MTAD) mediates interaction with the RNA polymerase II holoenzyme and stimulates transcriptional activation in a CREB-dependent manner. The oligonucleotide- or oligosaccharide-binding (OB-fold) and the repeated arginine and glycine-glycine (RGG) regions are dispensable for both RNA-binding and unwinding helicase activities. The RGG region contains both nuclear localization signal (NLS) and nuclear export signal (NES) and is necessary and sufficient for nucleocytoplasmic shuttling in a RNA-independent manner.
messages: Methylated. PRMT1-mediated methylation of undefined Arg residues in the nuclear transport domain (NTD) is required for nuclear import of DHX9.
messages: Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes. Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA. Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process…
messages: Nucleus
messages: Phosphorylated by PRKDC; phosphorylation occurs in a RNA-dependent manner. Phosphorylated by EIF2AK2/PKR; this phosphorylation reduces its association with double-stranded RNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: nucleolus
messages: nucleoplasm

9601:TMEM234
gene id: 9601:TMEM234
uniprot id: A0A2J8Y7A7
uniprot id: H2N857
uniprot id: Q5RBQ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BLVRA
gene id: 9601:BLVRA
uniprot id: A0A6D2YC68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9601:CX3CR1
gene id: 9601:CX3CR1
uniprot id: A0A2J8WY16
uniprot id: A0A6D2XR01
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HOXC12
gene id: 9601:HOXC12
uniprot id: H2NHI5
names: Subcellular Location Annotation
messages: Nucleus

9601:VEZT
gene id: 9601:VEZT
uniprot id: H2NIA6
uniprot id: Q5RFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Interacts with USH2A (via the cytoplasmic region); the interaction associates VEZT with the USH2 complex at the stereocilia base (By similarity). Interacts with myosin MYO7A and the cadherin-catenins complex (By similarity).
messages: Membrane
messages: Nucleus
messages: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
messages: acrosome
messages: adherens junction
messages: stereocilium membrane

9601:TGM1
gene id: 9601:TGM1
uniprot id: H2NKW2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:NDEL1
gene id: 9601:NDEL1
uniprot id: A0A2J8RW45
uniprot id: K7EVG9
uniprot id: Q5R8T7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Palmitoylation at Cys-273 reduces affinity for dynein.
messages: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity).
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
messages: Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, microtubules, PAFAH1B1, PCM1, PCNT, and YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts (via C-terminus) with CENPF. Interacts with ZNF365. Interacts with PLEKHM1 (via N- and C-terminus).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle

9601:LGSN
gene id: 9601:LGSN
uniprot id: A0A2J8XWW7
uniprot id: H2PJH0
names: Similarity
messages: Belongs to the glutamine synthetase family.

9601:MTMR6
gene id: 9601:MTMR6
uniprot id: Q5R5S2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9601:LOC100452375
gene id: 9601:LOC100452375
uniprot id: H2NEH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ISY1
gene id: 9601:ISY1
uniprot id: H2P9E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9601:ADAMDEC1
gene id: 9601:ADAMDEC1
uniprot id: A0A2J8X4Y1
uniprot id: H2PPU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRPF4
gene id: 9601:PRPF4
uniprot id: Q5NVD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the precatalytic spliceosome (spliceosome B complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Interacts directly with PRPF18, PPIH and PRPF3 (By similarity). Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA (By similarity). Interacts with ERCC6 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9601:DNAJC21
gene id: 9601:DNAJC21
uniprot id: A0A2J8WB35
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPAG9
gene id: 9601:SPAG9
uniprot id: A0A2J8W8B0
names: Similarity
messages: Belongs to the JIP scaffold family.

9601:DYNLRB2
gene id: 9601:DYNLRB2
uniprot id: A0A2J8VWW4
uniprot id: H2NRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9601:ZNF436
gene id: 9601:ZNF436
uniprot id: Q5R5Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:CLCN2
gene id: 9601:CLCN2
uniprot id: A0A663D896
uniprot id: H2PC70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9601:PSMD1
gene id: 9601:PSMD1
uniprot id: A0A2J8TQE8
uniprot id: Q5R5S4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1. Interacts with ADRM1. Interacts with ZFAND1 (By similarity).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADORA2B
gene id: 9601:ADORA2B
uniprot id: H2NSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9601:TSPAN6
gene id: 9601:TSPAN6
uniprot id: A0A2J8U651
uniprot id: Q5RAS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGF1
gene id: 9601:FGF1
uniprot id: Q5NVQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: In the nucleus, phosphorylated by PKC/PRKCD.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
messages: Secreted
messages: cell cortex
messages: cytosol

9601:DRAM2
gene id: 9601:DRAM2
uniprot id: A0A6D2Y7H1
names: Subcellular Location Annotation
messages: Membrane

9601:GABRB2
gene id: 9601:GABRB2
uniprot id: A0A2J8X6Y9
uniprot id: A0A6D2VWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:DYRK2
gene id: 9601:DYRK2
uniprot id: A0A2J8W0Y6
uniprot id: H2NHZ2
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRPC4AP
gene id: 9601:TRPC4AP
uniprot id: A0A2J8VJ26
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP6V1G2
gene id: 9601:ATP6V1G2
uniprot id: A0A8I5TTQ6
uniprot id: A0A8I5YLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9601:RHOA
gene id: 9601:RHOA
uniprot id: Q5REY6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cleavage furrow
messages: Interacts with ARHGEF28 (By similarity). Interacts (via GTP-bound form) with RIPOR1 (via N-terminus); this interaction links RHOA to STK24 and STK26 kinases. Interacts with RIPOR2 (via active GTP- or inactive GDP-bound forms) isoform 1 and isoform 2; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes. Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with DIAPH1. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA. Interacts with ARHGDIB. Interacts (GTP-bound form) with KCNA2 (via cytoplasmic N-terminal domain) (By similarity). Interacts (GTP-bound form) with ECT2; the interaction results in allosteric activation of ECT2 (By similarity). Interacts with RAP1GDS1; the interaction is direct and in a 1:1 stoichiometry (By similarity).
messages: Midbody
messages: Nucleus
messages: Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (By similarity). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as ARHGEF2, ARHGEF3, ARHGEF28 and BCR. Inhibited by GAPs such as ARHGAP30. Inhibited by GDP dissociation inhibitors such as ARHGDIA.
messages: Serotonylation of Gln-63 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. May be an activator of PLCE1. In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
messages: Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons.
messages: cell cortex
messages: cytoskeleton
messages: dendrite
messages: lamellipodium

9601:SACM1L
gene id: 9601:SACM1L
uniprot id: Q5R921
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with TMEM39A (By similarity). Interacts with SEC23A and SEC24A; this interaction is reduced in the absence of TMEM39A (By similarity). Interacts with PLEKHA3 and VAPA and/or VAPB to form a ternary complex (By similarity).
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity).

9601:THUMPD3
gene id: 9601:THUMPD3
uniprot id: A0A6D2WE99
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9601:FCHSD2
gene id: 9601:FCHSD2
uniprot id: A0A2J8V1M9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL10
gene id: 9601:RPL10
uniprot id: A0A6D2XTB8
uniprot id: Q5R931
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Ufmylated by UFL1.

9601:HOXC6
gene id: 9601:HOXC6
uniprot id: A0A6D2VZ15
uniprot id: H2NHJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DARS
gene id: 9601:DARS
uniprot id: Q5R9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: Cytoplasm
messages: Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.

9601:RNF152
gene id: 9601:RNF152
uniprot id: H2NWG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9601:EXOC5
gene id: 9601:EXOC5
uniprot id: H2NLC2
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9601:LOC100449901
gene id: 9601:LOC100449901
uniprot id: A0A2J8SW13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:NPRL2
gene id: 9601:NPRL2
uniprot id: H2PAN5
names: Similarity
messages: Belongs to the NPR2 family.

9601:ARID4B
gene id: 9601:ARID4B
uniprot id: A0A2J8UDZ6
uniprot id: A0A6D2WLA2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EMC9
gene id: 9601:EMC9
uniprot id: A0A2J8TRI4
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9601:TMEM230
gene id: 9601:TMEM230
uniprot id: Q5R8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9601:MDFIC
gene id: 9601:MDFIC
uniprot id: A0A663DCH6
names: Caution
names: Similarity
messages: Belongs to the MDFI family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TFPI2
gene id: 9601:TFPI2
uniprot id: A0A663DBI7
uniprot id: H2PMX0
names: Caution
names: Subcellular Location Annotation
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTX2
gene id: 9601:MTX2
uniprot id: H2P7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:CLDN11
gene id: 9601:CLDN11
uniprot id: H2PBZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:GNAL
gene id: 9601:GNAL
uniprot id: A0A6D2W0A6
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9601:SLC4A3
gene id: 9601:SLC4A3
uniprot id: Q5RAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9601:RUFY3
gene id: 9601:RUFY3
uniprot id: Q5R4V2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell projection
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with PAK1. Interacts (via C-terminus) with Ras-related Rab-5 proteins. Interacts (via C-terminus) with Ras-related Rap-2 proteins. Interacts with PIK3CA and PIK3R1. Interacts (via N-terminus) with FSCN1; this interaction induces neuron axon development. Interacts with DBN1.
messages: Perikaryon
messages: Phosphorylated by PAK1.
messages: Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner.
messages: filopodium
messages: growth cone
messages: invadopodium
messages: lamellipodium

9601:F2R
gene id: 9601:F2R
uniprot id: H2PFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CRY1
gene id: 9601:CRY1
uniprot id: A0A663D859
uniprot id: H2NII4
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9601:IL1RAPL2
gene id: 9601:IL1RAPL2
uniprot id: H2PWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane

9601:MSRB1
gene id: 9601:MSRB1
uniprot id: Q5R869
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
messages: Nucleus
messages: Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(FEM1C) E3 ubiquitin-protein ligase complex.
messages: cytoskeleton

9601:HSPB3
gene id: 9601:HSPB3
uniprot id: A0A663D5E0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLTA
gene id: 9601:CLTA
uniprot id: A0A2J8T083
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9601:PDE1A
gene id: 9601:PDE1A
uniprot id: A0A2J8RJW9
uniprot id: Q5R9Z0
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NAP1L1
gene id: 9601:NAP1L1
uniprot id: A0A2J8W1G6
uniprot id: A0A6D2X101
uniprot id: Q5R4D4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Cytoplasm
messages: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
messages: Homodimer. The dimer binds strongly and sequentially to single and double H2A-H2B heterodimers. Interacts with ERCC6; this interaction increases ERCC6 processivity. Interacts with RAD54 (By similarity). Interacts with SETD1A (By similarity).
messages: Melanosome
messages: Nucleus
messages: Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
messages: Polyglycylated by TTLL10 on glutamate residues, resulting in polyglycine chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
messages: The NAP1L motif is required for the histone chaperone activity.
messages: The acidic domains are probably involved in the interaction with histones.

9601:FERMT1
gene id: 9601:FERMT1
uniprot id: Q5R8M5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kindlin family.
messages: Interacts with the cytoplasmic domain of integrins ITGB1 and ITGB3.
messages: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity).
messages: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions (By similarity).
messages: cytoskeleton
messages: focal adhesion
messages: ruffle membrane

9601:LOC100454867
gene id: 9601:LOC100454867
uniprot id: A0A8I5U965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9601:LOC100444716
gene id: 9601:LOC100444716
uniprot id: H2PI50
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:ZNF248
gene id: 9601:ZNF248
uniprot id: A0A2J8U304
uniprot id: A0A6D2Y6G0
uniprot id: Q5REN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:SURF4
gene id: 9601:SURF4
uniprot id: A0A2J8UIY1
uniprot id: Q5R705
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STING1. Interacts with SAR1B. Interacts with TMEM41B (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SMAD3
gene id: 9601:SMAD3
uniprot id: A0A663DHH9
uniprot id: H2NNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9601:CUTC
gene id: 9601:CUTC
uniprot id: H2NB98
names: Similarity
messages: Belongs to the CutC family.

9601:DMPK
gene id: 9601:DMPK
uniprot id: A0A2J8U6P1
uniprot id: A0A2J8U6P7
uniprot id: A0A2J8U6Q5
uniprot id: A0A2J8U6R4
uniprot id: H2NZ96
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLDN2
gene id: 9601:CLDN2
uniprot id: A0A6D2XRQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:CNPY4
gene id: 9601:CNPY4
uniprot id: A0A663D7G9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VPS37B
gene id: 9601:VPS37B
uniprot id: H2NJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9601:ANP32B
gene id: 9601:ANP32B
uniprot id: H2PSU9
names: Similarity
messages: Belongs to the ANP32 family.

9601:CYREN
gene id: 9601:CYREN
uniprot id: A0A2J8V3Q5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:APOC4
gene id: 9601:APOC4
uniprot id: A0A8I5T6G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9601:TUFM
gene id: 9601:TUFM
uniprot id: H2NQI4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9601:ZNF256
gene id: 9601:ZNF256
uniprot id: A0A2J8RQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:JPH2
gene id: 9601:JPH2
uniprot id: A0A2J8XVZ8
uniprot id: H2P1Z6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NDUFC2
gene id: 9601:NDUFC2
uniprot id: A0A8I5TWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9601:P2RY11
gene id: 9601:P2RY11
uniprot id: A0A8I5UF78
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:MTX3
gene id: 9601:MTX3
uniprot id: A0A6D2WCT0
uniprot id: H2PFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:GPX5
gene id: 9601:GPX5
uniprot id: A0A2J8SJY1
uniprot id: A0A6D2WSV3
uniprot id: H2PIB1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9601:LOC100458923
gene id: 9601:LOC100458923
uniprot id: A0A2J8STV8
uniprot id: Q5RBF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IAH1
gene id: 9601:IAH1
uniprot id: H2P702
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9601:SEMA4B
gene id: 9601:SEMA4B
uniprot id: A0A2J8VX78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPZL2
gene id: 9601:MPZL2
uniprot id: Q5R804
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin P0 protein family.
messages: Mediates homophilic cell-cell adhesion.
messages: Membrane

9601:FAM171A1
gene id: 9601:FAM171A1
uniprot id: Q5RD34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM171 family.
messages: Cell membrane
messages: Interacts with ADAM10, NSG1 and OAZ1.
messages: Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation.

9601:SDHA
gene id: 9601:SDHA
uniprot id: A0A2J8XSC5
uniprot id: Q5R616
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylated by SIRT3.
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity). Interacts with LACC1 (By similarity).
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.
messages: Mitochondrion inner membrane
messages: Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC6A15
gene id: 9601:SLC6A15
uniprot id: A0A2J8SW81
uniprot id: Q5R9C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C15H15orf40
gene id: 9601:C15H15orf40
uniprot id: A0A6D2W1G5
names: Similarity
messages: Belongs to the UPF0235 family.

9601:IRGQ
gene id: 9601:IRGQ
uniprot id: A0A6D2WKM0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9601:SLC6A1
gene id: 9601:SLC6A1
uniprot id: A0A6D2W8X6
uniprot id: H2PA22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP10D
gene id: 9601:ATP10D
uniprot id: H2PD85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9601:ESRP1
gene id: 9601:ESRP1
uniprot id: A0A2J8UGF7
uniprot id: A0A2J8UGK2
uniprot id: H2PQT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LALBA
gene id: 9601:LALBA
uniprot id: H2NH48
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9601:NUCB1
gene id: 9601:NUCB1
uniprot id: Q5R4U1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 with higher affinity for GNAI1 and GNAI3 than for GNAI2. Preferentially interacts with inactive rather than active GNAI3. Interaction with GNAI3 is inhibited when NUCB1 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible.
messages: Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).
messages: Secreted
messages: The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
messages: cis-Golgi network membrane

9601:PHLDA2
gene id: 9601:PHLDA2
uniprot id: H2NCH6
names: Subcellular Location Annotation
messages: Cytoplasm

9601:TOX2
gene id: 9601:TOX2
uniprot id: A0A2J8XW21
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GDA
gene id: 9601:GDA
uniprot id: A0A2J8SUE4
uniprot id: Q5RAV9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
messages: Homodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100438174
gene id: 9601:LOC100438174
uniprot id: A0A1K0GUW6
names: Similarity
messages: Belongs to the globin family.

9601:GBP2
gene id: 9601:GBP2
uniprot id: A0A6D2WYF8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9601:CLEC7A
gene id: 9601:CLEC7A
uniprot id: A0A2J8RGR2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GALNT6
gene id: 9601:GALNT6
uniprot id: A0A6D2XQW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9601:TRIM72
gene id: 9601:TRIM72
uniprot id: H2NQS6
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: sarcolemma

9601:CRYBA1
gene id: 9601:CRYBA1
uniprot id: H2NT62
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9601:AKR1B1
gene id: 9601:AKR1B1
uniprot id: Q5RAB3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9601:CSKMT
gene id: 9601:CSKMT
uniprot id: A0A2J8TXX3
uniprot id: Q5RCI5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily.
messages: Citrate synthase-lysine methyltransferase activity is inhibited by S-adenosylhomocysteine (AdoHcy) and oxaloacetate (OAA).
messages: Mitochondrion
messages: Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XPA
gene id: 9601:XPA
uniprot id: K7EUV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9601:DDAH2
gene id: 9601:DDAH2
uniprot id: A0A6D2XME4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9601:ANAPC15
gene id: 9601:ANAPC15
uniprot id: A0A2J8V1Z2
uniprot id: A0A2J8V1Z5
uniprot id: A0A6D2W611
names: Caution
names: Similarity
messages: Belongs to the APC15 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LRRN3
gene id: 9601:LRRN3
uniprot id: Q5R482
names: Subcellular Location Annotation
messages: Membrane

9601:PCYOX1
gene id: 9601:PCYOX1
uniprot id: H2P5X6
uniprot id: Q5R748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prenylcysteine oxidase family.
messages: Lysosome
messages: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (By similarity).

9601:ITGB6
gene id: 9601:ITGB6
uniprot id: Q5RDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9601:TAF9
gene id: 9601:TAF9
uniprot id: A0A2J8VTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9601:WASF1
gene id: 9601:WASF1
uniprot id: Q5NVG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
messages: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus) (By similarity). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (By similarity).
messages: Synapse
messages: cytoskeleton
messages: focal adhesion

9601:GINM1
gene id: 9601:GINM1
uniprot id: A0A2J8XA96
uniprot id: Q5RBQ2
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPEB1
gene id: 9601:CPEB1
uniprot id: Q5R733
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM CPEB family.
messages: Cytoplasmic granule
messages: Interacts with kinesin, dynein, APLP1, APLP2, TENT2/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (By similarity). Interacts with TENT4B; the interaction is required for TENT4B-mediated translational control (By similarity).
messages: Membrane
messages: P-body
messages: Phosphorylated on serine/threonine residues by AURKA within positions 91 and 122. Phosphorylation and dephosphorylation on Thr-97 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-97 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-97 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).
messages: Postsynaptic density
messages: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry.
messages: Synapse
messages: The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA. The interdomain linker (411-429) acts as a hinge to fix the relative orientation of the 2 RRMs. The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs. A continuous hydrophobic interface is formed between the 2 RRM.
messages: dendrite

9601:EFNA1
gene id: 9601:EFNA1
uniprot id: H2N5I2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:RAD51
gene id: 9601:RAD51
uniprot id: A0A663DBM7
uniprot id: H2NMV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9601:NKAP
gene id: 9601:NKAP
uniprot id: H2PWM4
names: Similarity
messages: Belongs to the NKAP family.

9601:PSMA3
gene id: 9601:PSMA3
uniprot id: H2NLC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9601:PSMD3
gene id: 9601:PSMD3
uniprot id: K7EVP2
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9601:VPS53
gene id: 9601:VPS53
uniprot id: A0A2J8SNJ4
uniprot id: Q5R5J4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (By similarity). Interacts with VPS50 in an EIPR1-independent manner (By similarity).
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: trans-Golgi network membrane

9601:LOC100453911
gene id: 9601:LOC100453911
uniprot id: H2NZL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9601:TRAPPC2L
gene id: 9601:TRAPPC2L
uniprot id: A0A2J8RVF1
uniprot id: A0A663DIV0
uniprot id: H2NRS7
uniprot id: Q5RBK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: perinuclear region

9601:GRIA2
gene id: 9601:GRIA2
uniprot id: A0A2J8W0A8
uniprot id: A0A2J8W0E4
uniprot id: H2PEL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IGF1
gene id: 9601:IGF1
uniprot id: A0A2J8XMB2
uniprot id: A0A2J8XMB9
uniprot id: A0A2J8XMC3
uniprot id: A0A663DE66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9601:LOC100460311
gene id: 9601:LOC100460311
uniprot id: H2NKI8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9601:OAS1
gene id: 9601:OAS1
uniprot id: Q5R8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9601:SAA2
gene id: 9601:SAA2
uniprot id: Q5NVR7
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9601:FOXR2
gene id: 9601:FOXR2
uniprot id: H2PVT0
names: Subcellular Location Annotation
messages: Nucleus

9601:SLIRP
gene id: 9601:SLIRP
uniprot id: A0A2J8W5Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9601:CDR2
gene id: 9601:CDR2
uniprot id: A0A663DFW7
uniprot id: H2NQD7
names: Caution
names: Similarity
messages: Belongs to the CDR2 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TYROBP
gene id: 9601:TYROBP
uniprot id: A0A2J8RRV9
uniprot id: A0A2J8RRW1
uniprot id: A0A2J8RRY5
uniprot id: A0A663DBW1
uniprot id: H2NYJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRSF5
gene id: 9601:SRSF5
uniprot id: A0A2J8T4R7
uniprot id: A0A6D2XLX8
names: Caution
names: Similarity
messages: Belongs to the splicing factor SR family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MBTPS2
gene id: 9601:MBTPS2
uniprot id: A0A6D2XMY2
names: Similarity
messages: Belongs to the peptidase M50A family.

9601:MTFR2
gene id: 9601:MTFR2
uniprot id: A0A2J8X9X4
uniprot id: A0A6D2WNR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ENY2
gene id: 9601:ENY2
uniprot id: A0A2J8X389
uniprot id: A0A6D2X1V3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleoplasm

9601:SMIM5
gene id: 9601:SMIM5
uniprot id: A0A2J8Y0W8
names: Subcellular Location Annotation
messages: Membrane

9601:EIF1
gene id: 9601:EIF1
uniprot id: A0A2J8WAP2
uniprot id: Q5RFF4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SUI1 family.
messages: Interacts with RENT2.
messages: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPHA2
gene id: 9601:GPHA2
uniprot id: A0A663DBV7
uniprot id: H2NCY3
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MAP2K6
gene id: 9601:MAP2K6
uniprot id: A0A2J8V0E7
uniprot id: H2NUJ7
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WNT3
gene id: 9601:WNT3
uniprot id: H2NTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9601:AQP11
gene id: 9601:AQP11
uniprot id: H2NER5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9601:PCSK1
gene id: 9601:PCSK1
uniprot id: Q5R7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9601:EREG
gene id: 9601:EREG
uniprot id: H2PDL6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:LOC100433709
gene id: 9601:LOC100433709
uniprot id: A0A2J8WUC6
names: Caution
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IQCH
gene id: 9601:IQCH
uniprot id: A0A2J8UCB1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPL19
gene id: 9601:MRPL19
uniprot id: A0A2J8SF01
uniprot id: Q5R8M4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSF2
gene id: 9601:CSF2
uniprot id: H2PGH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9601:PJA1
gene id: 9601:PJA1
uniprot id: A0A803KHE3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RANGRF
gene id: 9601:RANGRF
uniprot id: H2NSN3
names: Similarity
messages: Belongs to the MOG1 family.

9601:API5
gene id: 9601:API5
uniprot id: A0A2J8WFN5
uniprot id: Q5R644
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-251 impairs antiapoptotic function.
messages: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity).
messages: Belongs to the API5 family.
messages: Cytoplasm
messages: Monomer. Interacts with FGF2 and ACIN1 (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHAC1
gene id: 9601:CHAC1
uniprot id: A0A2J8S5W9
uniprot id: A0A6D2WFN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NMS
gene id: 9601:NMS
uniprot id: H2P579
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9601:SYNPR
gene id: 9601:SYNPR
uniprot id: A0A2J8TEJ0
uniprot id: A0A663DG78
uniprot id: H2PAC8
uniprot id: Q5R9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9601:ZNF7
gene id: 9601:ZNF7
uniprot id: A0A2J8RHZ7
uniprot id: H2PRJ0
uniprot id: Q5RBX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NTF4
gene id: 9601:NTF4
uniprot id: H2NZL3
names: Similarity
messages: Belongs to the NGF-beta family.

9601:CERS5
gene id: 9601:CERS5
uniprot id: H2NH96
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9601:KRTCAP2
gene id: 9601:KRTCAP2
uniprot id: H2N5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9601:PA2G4
gene id: 9601:PA2G4
uniprot id: H2PXI8
uniprot id: Q5RF49
names: Similarity
messages: Belongs to the peptidase M24 family.

9601:TSC22D3
gene id: 9601:TSC22D3
uniprot id: A0A2J8VAR8
uniprot id: A0A2J8VAT7
uniprot id: Q5RED5
names: Caution
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).
messages: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 and NFKB1. Interacts with MYOD1. Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
messages: The leucine-zipper is involved in homodimerization.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IFFO1
gene id: 9601:IFFO1
uniprot id: A0A2J8TB39
uniprot id: A0A663DCU3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KIAA1324L
gene id: 9601:KIAA1324L
uniprot id: H2PN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9601:NUBP1
gene id: 9601:NUBP1
uniprot id: A0A8I5TKQ0
uniprot id: A0A8I5U5Z6
uniprot id: H2NQ41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9601:LOC100461332
gene id: 9601:LOC100461332
uniprot id: A0A663DED9
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9601:CPNE6
gene id: 9601:CPNE6
uniprot id: Q5R4W6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copine family.
messages: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Endosome
messages: Interacts (via second C2 domain) with OS9 (via C-terminus); this interaction occurs in a calcium-dependent manner in vitro. May interact with NECAB1.
messages: Perikaryon
messages: The C2 domain 1 binds phospholipids in a calcium-independent manner and is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 binds phospholipids in a calcium-dependent manner and is necessary for calcium-mediated translocation and association to the plasma membrane. The linker region contributes to the calcium-dependent translocation and association to the plasma membrane. The VWFA domain is necessary for association with intracellular clathrin-coated vesicles in a calcium-dependent manner.
messages: clathrin-coated vesicle
messages: dendrite

9601:KIAA1024
gene id: 9601:KIAA1024
uniprot id: H2NNZ7
names: Similarity
messages: Belongs to the MINAR family.

9601:TMEM192
gene id: 9601:TMEM192
uniprot id: Q5RCG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM192 family.
messages: Homodimer.
messages: Late endosome
messages: Lysosome membrane

9601:RHOXF2
gene id: 9601:RHOXF2
uniprot id: H2PWM6
names: Subcellular Location Annotation
messages: Nucleus

9601:MCTP2
gene id: 9601:MCTP2
uniprot id: H2NP92
names: Subcellular Location Annotation
messages: Membrane

9601:SLC16A4
gene id: 9601:SLC16A4
uniprot id: Q5R5G1
names: Subcellular Location Annotation
messages: Membrane

9601:HNRNPA2B1
gene id: 9601:HNRNPA2B1
uniprot id: A0A2J8VDX4
uniprot id: Q5RBU8
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methylation affects subcellular location and promotes nuclear localization (By similarity). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity).
messages: Cytoplasmic granule
messages: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1. Interacts with C9orf72. Interacts with DGCR8. Interacts with TARDBP. Interacts with CKAP5 (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Sumoylated in exosomes, promoting miRNAs-binding.
messages: The disordered region, when incubated at high concentration, is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidence suggests that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular exosome
messages: nucleoplasm

9601:DHRS3
gene id: 9601:DHRS3
uniprot id: H2N919
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:ASB5
gene id: 9601:ASB5
uniprot id: A0A663DCD1
uniprot id: H2PET1
names: Caution
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C5H5orf63
gene id: 9601:C5H5orf63
uniprot id: H2PGE6
names: Similarity
messages: Belongs to the glutaredoxin family.

9601:TMPRSS7
gene id: 9601:TMPRSS7
uniprot id: A0A2J8W2W9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:HLF
gene id: 9601:HLF
uniprot id: H2NTK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9601:PYCARD
gene id: 9601:PYCARD
uniprot id: A0A2J8TKW9
uniprot id: H2NQS5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9601:ST7L
gene id: 9601:ST7L
uniprot id: A0A2J8UM09
uniprot id: A0A2J8UM27
uniprot id: H2N6D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZSCAN22
gene id: 9601:ZSCAN22
uniprot id: A0A6D2X0V3
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100456432
gene id: 9601:LOC100456432
uniprot id: A0A2J8VFH5
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9601:LOC100462394
gene id: 9601:LOC100462394
uniprot id: A0A6D2XRC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CBX8
gene id: 9601:CBX8
uniprot id: K7EUB2
names: Subcellular Location Annotation
messages: Nucleus

9601:ANGPTL4
gene id: 9601:ANGPTL4
uniprot id: A0A6D2WCG6
names: Subcellular Location Annotation
messages: Secreted

9601:TAGLN2
gene id: 9601:TAGLN2
uniprot id: A0A6D2WZD2
names: Similarity
messages: Belongs to the calponin family.

9601:PCNP
gene id: 9601:PCNP
uniprot id: A0A2J8T915
uniprot id: Q5RCI9
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.

9601:CNR1
gene id: 9601:CNR1
uniprot id: A0A2J8VRN4
uniprot id: A0A6D2XW73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: axon

9601:URAD
gene id: 9601:URAD
uniprot id: H2NJI0
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9601:NUTF2
gene id: 9601:NUTF2
uniprot id: Q5R8G4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import.
messages: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: cytosol
messages: nuclear pore complex
messages: nucleoplasm

9601:MAK16
gene id: 9601:MAK16
uniprot id: A0A663D8S1
names: Similarity
messages: Belongs to the MAK16 family.

9601:GBP6
gene id: 9601:GBP6
uniprot id: Q5R9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: Cytoplasmic vesicle
messages: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity).

9601:AMIGO1
gene id: 9601:AMIGO1
uniprot id: A0A6D2WQP2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9601:GINS4
gene id: 9601:GINS4
uniprot id: A0A6D2XKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9601:TMED5
gene id: 9601:TMED5
uniprot id: Q5R809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).
messages: cis-Golgi network membrane

9601:FCN2
gene id: 9601:FCN2
uniprot id: A0A6D2WI54
names: Similarity
messages: Belongs to the ficolin lectin family.

9601:PNPT1
gene id: 9601:PNPT1
uniprot id: H2P660
uniprot id: Q5RCW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Homotrimer; in free form. Homooligomer. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. As part of the mitochondrial degradosome complex, interacts with GRSF1 in an RNA-dependent manner; the interaction enhances the activity of the complex. Interacts with TCL1A; the interaction has no effect on PNPT1 exonuclease activity.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA (By similarity).

9601:GPR25
gene id: 9601:GPR25
uniprot id: H2N488
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:LOC100433392
gene id: 9601:LOC100433392
uniprot id: H2PI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9601:ARHGEF7
gene id: 9601:ARHGEF7
uniprot id: A0A2J8X812
uniprot id: A0A2J8X813
uniprot id: A0A2J8X827
uniprot id: H2NKC0
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: lamellipodium

9601:SURF6
gene id: 9601:SURF6
uniprot id: A0A663D7K5
names: Similarity
messages: Belongs to the SURF6 family.

9601:DNAJA1
gene id: 9601:DNAJA1
uniprot id: Q5NVI9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).
messages: Cytoplasm
messages: Identified in a complex with HSPA1B and BAX. Interacts with RNF207.
messages: Membrane
messages: Microsome
messages: Mitochondrion
messages: Nucleus
messages: perinuclear region

9601:TYMS
gene id: 9601:TYMS
uniprot id: H2NVZ8
names: Similarity
messages: Belongs to the thymidylate synthase family.

9601:HACD2
gene id: 9601:HACD2
uniprot id: A0A2J8W1S8
uniprot id: Q5RBK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex. Interacts with BCAP31.
messages: Membrane
messages: Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MX1
gene id: 9601:MX1
uniprot id: Q5R5G3
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9601:TCHP
gene id: 9601:TCHP
uniprot id: Q5RE49
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCHP family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Interacts with KCTD17 (By similarity).
messages: Mitochondrion
messages: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).
messages: Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.
messages: cytoskeleton

9601:OAT
gene id: 9601:OAT
uniprot id: Q5R9M1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9601:DIEXF
gene id: 9601:DIEXF
uniprot id: A0A6D2VV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9601:GPR68
gene id: 9601:GPR68
uniprot id: H2NM12
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:GOLGA5
gene id: 9601:GOLGA5
uniprot id: H2NM29
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9601:ZNF271
gene id: 9601:ZNF271
uniprot id: Q5R5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:CDC42EP3
gene id: 9601:CDC42EP3
uniprot id: A0A6D2WX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9601:APOBR
gene id: 9601:APOBR
uniprot id: A0A6D2W9W4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PICK1
gene id: 9601:PICK1
uniprot id: A0A2J8UWE6
uniprot id: Q5REH1
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition (By similarity).
messages: Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).
messages: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
messages: Postsynaptic density
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity).
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: The AH domain mediates binding to F-actin.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9601:MEOX1
gene id: 9601:MEOX1
uniprot id: A0A2J8UY45
uniprot id: H2NTW4
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:APOL4
gene id: 9601:APOL4
uniprot id: Q5R841
names: Similarity
messages: Belongs to the apolipoprotein L family.

9601:SRPX
gene id: 9601:SRPX
uniprot id: H2PVA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:KCNMB2
gene id: 9601:KCNMB2
uniprot id: H2PC26
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9601:PGC
gene id: 9601:PGC
uniprot id: B9A851
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

9601:PPP2R5C
gene id: 9601:PPP2R5C
uniprot id: Q5R4P5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9601:TSEN15
gene id: 9601:TSEN15
uniprot id: A0A6D2VVI0
uniprot id: H2N4E6
names: Similarity
messages: Belongs to the SEN15 family.

9601:DLG3
gene id: 9601:DLG3
uniprot id: A0A2J8UBH0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COPS3
gene id: 9601:COPS3
uniprot id: A0A2J8RIE2
uniprot id: Q5RFS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity).
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 (By similarity). Interacts with CK2 and PKD (By similarity). Interacts with the translation initiation factor EIF3S6 and IKBKG (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XRCC1
gene id: 9601:XRCC1
uniprot id: H2NZ27
names: Subcellular Location Annotation
messages: Nucleus

9601:SYPL1
gene id: 9601:SYPL1
uniprot id: Q5RF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9601:ARL4D
gene id: 9601:ARL4D
uniprot id: A0A2J8UY40
uniprot id: Q5REU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D (By similarity).
messages: Nucleus
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:DCUN1D4
gene id: 9601:DCUN1D4
uniprot id: A0A2J8SGF7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HSF2
gene id: 9601:HSF2
uniprot id: A0A2J8TAB8
uniprot id: H2PK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9601:SAMD8
gene id: 9601:SAMD8
uniprot id: A0A2J8U5C5
uniprot id: A0A2J8U5E1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMED2
gene id: 9601:TMED2
uniprot id: K7EUK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9601:CCNC
gene id: 9601:CCNC
uniprot id: A0A2J8VS02
uniprot id: A0A6D2XA10
uniprot id: H2PJV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9601:GCDH
gene id: 9601:GCDH
uniprot id: Q5R5K1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9601:KRT32
gene id: 9601:KRT32
uniprot id: H2NU35
names: Similarity
messages: Belongs to the intermediate filament family.

9601:NSRP1
gene id: 9601:NSRP1
uniprot id: H2NT72
names: Similarity
messages: Belongs to the NSRP1 family.

9601:SOST
gene id: 9601:SOST
uniprot id: A0A2J8UY42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

9601:GPI
gene id: 9601:GPI
uniprot id: Q5R4E3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer; in the catalytically active form. Monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9601:ACTR3B
gene id: 9601:ACTR3B
uniprot id: H2PP45
names: Similarity
messages: Belongs to the actin family.

9601:MAPRE2
gene id: 9601:MAPRE2
uniprot id: A0A2J8XFM8
uniprot id: A0A2J8XG07
uniprot id: Q5R4I6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPRE family.
messages: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1 (By similarity).
messages: Cytoplasm
messages: Interacts with DCTN1. Interacts with APC (via C-terminal). Interacts with monomeric and polymerized tubulin. Interacts with SLAIN1.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:SPG7
gene id: 9601:SPG7
uniprot id: H2NRT9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9601:GNB3
gene id: 9601:GNB3
uniprot id: H2NGA0
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9601:PI4KB
gene id: 9601:PI4KB
uniprot id: A0A2J8VF30
uniprot id: A0A2J8VF34
uniprot id: A0A6D2VSC2
uniprot id: A0A8I5TYB5
names: Caution
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:APOD
gene id: 9601:APOD
uniprot id: H2PCF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9601:F10
gene id: 9601:F10
uniprot id: H2NKD5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:GNAQ
gene id: 9601:GNAQ
uniprot id: A0A6D2WDJ0
uniprot id: H2PSG4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9601:HSPA6
gene id: 9601:HSPA6
uniprot id: A0A663D9Z9
uniprot id: H2N503
names: Caution
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BDNF
gene id: 9601:BDNF
uniprot id: A0A2J8S4J0
uniprot id: A0A2J8S4K3
uniprot id: A0A2J8S4K4
uniprot id: A0A6D2Y4R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NSUN4
gene id: 9601:NSUN4
uniprot id: A0A2J8SLI7
uniprot id: H2N7J1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9601:RPS23
gene id: 9601:RPS23
uniprot id: A0A6D2X9I0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9601:TMEM265
gene id: 9601:TMEM265
uniprot id: A0A2J8TKI6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9601:ATP1B1
gene id: 9601:ATP1B1
uniprot id: A0A2J8SAS6
uniprot id: Q5R8S8
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Glutathionylated (By similarity). N-glycosylated (By similarity).
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
messages: sarcolemma

9601:TAGLN
gene id: 9601:TAGLN
uniprot id: A0A6D2XZI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9601:XK
gene id: 9601:XK
uniprot id: A0A6D2Y4J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9601:RAB3C
gene id: 9601:RAB3C
uniprot id: A0A8I5TRJ0
uniprot id: H2PFL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9601:LOC100457600
gene id: 9601:LOC100457600
uniprot id: K7ETG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9601:MFSD6L
gene id: 9601:MFSD6L
uniprot id: H2NSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9601:PIGP
gene id: 9601:PIGP
uniprot id: A0A6D2W011
uniprot id: Q5R946
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGP family.
messages: Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts directly with PIGA and PIGQ.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
messages: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.

9601:CLIC2
gene id: 9601:CLIC2
uniprot id: H2PXC0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9601:CKAP2
gene id: 9601:CKAP2
uniprot id: Q5R7F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with alpha- and beta-tubulins.
messages: Belongs to the CKAP2 family.
messages: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
messages: cytoskeleton

9601:TRMT5
gene id: 9601:TRMT5
uniprot id: A0A663D8V2
uniprot id: H2NLF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC6A19
gene id: 9601:SLC6A19
uniprot id: Q5R6J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
messages: Interacts in a tissue-specific manner with ACE2 in small intestine and with CLTRN in the kidney. Interacts with CLTRN; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in kidneys. Interacts with ACE2; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in intestine. Interacts with ANPEP; the interaction positively regulates its amino acid transporter activity (By similarity).
messages: Membrane
messages: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.

9601:TMEM246
gene id: 9601:TMEM246
uniprot id: Q5R868
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP4 family.
messages: Contains three transmembrane domains, including a tandem transmembrane domain insertion into its glycosyltransferase-A fold. Transmembrane domain 1 functions as a signal for Golgi targeting.
messages: Golgi apparatus membrane
messages: Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for the initial step of GPI-GalNAc biosynthesis, transfers GalNAc to GPI in the Golgi after fatty acid remodeling by PGAP2.
messages: The conserved DXD motif is involved in enzyme activity.

9601:TMEM161B
gene id: 9601:TMEM161B
uniprot id: A0A6D2WLN2
uniprot id: H2PG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9601:RAN
gene id: 9601:RAN
uniprot id: A0A2J8S8Q4
uniprot id: Q5R556
uniprot id: Q5R6H0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65.
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.
messages: Melanosome
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1. Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct. Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex. Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Found in a nuclear export complex with RANBP3 and XPO1. Interacts with RANBP2/NUP358. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (By similarity). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with RANBP9 and RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MA…
messages: Nucleus
messages: Nucleus envelope
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:CCDC181
gene id: 9601:CCDC181
uniprot id: Q5NVK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC181 family.
messages: Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9601:VAT1
gene id: 9601:VAT1
uniprot id: H2NTX7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9601:ZNF764
gene id: 9601:ZNF764
uniprot id: A0A2J8TKG8
uniprot id: A0A2J8TKH6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BIRC2
gene id: 9601:BIRC2
uniprot id: A0A6D2XY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9601:KDELR2
gene id: 9601:KDELR2
uniprot id: A0A2J8R552
uniprot id: H2PLF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:NOL3
gene id: 9601:NOL3
uniprot id: A0A6D2VWC8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ERMN
gene id: 9601:ERMN
uniprot id: H2P7L0
uniprot id: Q5R6D6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
messages: cytoskeleton

9601:GOLPH3
gene id: 9601:GOLPH3
uniprot id: H2PF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9601:AMOT
gene id: 9601:AMOT
uniprot id: A0A2J8VAB7
uniprot id: A0A6D2XEG2
names: Caution
names: Similarity
messages: Belongs to the angiomotin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TUBGCP4
gene id: 9601:TUBGCP4
uniprot id: A0A2J8S5B2
uniprot id: A0A8I5TFC5
uniprot id: H2NN13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome

9601:ST13
gene id: 9601:ST13
uniprot id: Q5RF31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM10 family.
messages: Cytoplasm
messages: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5 (By similarity).
messages: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

9601:PSMD10
gene id: 9601:PSMD10
uniprot id: A0A2J8VAP2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPQ
gene id: 9601:CPQ
uniprot id: Q5RDN7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family.
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active (By similarity).
messages: Lysosome
messages: N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains.
messages: Secreted

9601:CCR5
gene id: 9601:CCR5
uniprot id: A0A2J8TFF9
uniprot id: P61756
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
messages: Palmitoylation in the C-terminal is important for cell surface expression.
messages: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HS2ST1
gene id: 9601:HS2ST1
uniprot id: Q5R621
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).
messages: Golgi apparatus membrane
messages: Homotrimer. Interacts with the C5-epimerase GLCE (By similarity).
messages: N-glycosylated.

9601:C9
gene id: 9601:C9
uniprot id: H2PFE3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

9601:SVOP
gene id: 9601:SVOP
uniprot id: Q5R5T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: synaptic vesicle membrane

9601:CDX4
gene id: 9601:CDX4
uniprot id: H2PW16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9601:NR1D2
gene id: 9601:NR1D2
uniprot id: H2PBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9601:NDUFA10
gene id: 9601:NDUFA10
uniprot id: H2P945
uniprot id: Q5R6H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9601:ALAS2
gene id: 9601:ALAS2
uniprot id: Q5R557
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: C-terminus is a mobile self-inhibitory loop which interferes directly with active site.
messages: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (By similarity). Contributes significantly to heme formation during erythropoiesis (By similarity).
messages: Homodimer. Interacts with SUCLA2.
messages: Mitochondrion inner membrane

9601:PDIA6
gene id: 9601:PDIA6
uniprot id: A0A2J8V446
uniprot id: Q5R6T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Cell membrane
messages: Endoplasmic reticulum lumen
messages: May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
messages: Melanosome
messages: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation. Interacts with ERN1; the interaction is direct. Interacts with EIF2AK3.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZCCHC11
gene id: 9601:ZCCHC11
uniprot id: A0A2J8V8P4
uniprot id: H2N7E0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100443592
gene id: 9601:LOC100443592
uniprot id: H2P9X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ZNF25
gene id: 9601:ZNF25
uniprot id: H2NA65
uniprot id: Q5RA54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:B3GALT5
gene id: 9601:B3GALT5
uniprot id: A0A2J8UAR4
uniprot id: A0A6D2WUQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHST14
gene id: 9601:CHST14
uniprot id: A0A663D6M7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPS7
gene id: 9601:RPS7
uniprot id: A0A6D2XEN9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9601:ACOT4
gene id: 9601:ACOT4
uniprot id: K7EVI7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9601:SH2D1A
gene id: 9601:SH2D1A
uniprot id: A0A2J8WWL7
uniprot id: H2PWP7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STK38
gene id: 9601:STK38
uniprot id: A0A2J8Y3K2
uniprot id: Q5R8M1
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38 (By similarity).
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimeric S100B binds two molecules of STK38. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase domain). Forms a tripartite complex with MOBKL1B and STK3/MST2. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4.
messages: ISGylated.
messages: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
messages: Nucleus
messages: Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM150C
gene id: 9601:TMEM150C
uniprot id: A0A2J8V4D1
names: Subcellular Location Annotation
messages: Membrane

9601:RPS9
gene id: 9601:RPS9
uniprot id: A0A6D2XUW5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9601:RPA1
gene id: 9601:RPA1
uniprot id: Q5R7Q4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the canonical replication protein A complex (RPA), a heterotrimer composed of RPA1, RPA2 and RPA3. The DNA-binding activity may reside exclusively on the RPA1 subunit. Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA). Interacts with RIPK1. Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp. Interacts with RAD51 and SENP6 to regulate DNA repair. Interacts with HELB; this interaction promotes HELB recruitment to chromatin following DNA damage. Interacts with PRIMPOL; leading to recruit PRIMPOL on chromatin and stimulate its DNA primase activity. Interacts with XPA; the interaction is direct and associates XPA with the RPA complex. Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks. Interacts with RPA1; this interaction associates HROB with the RPA complex (By similarity).
messages: DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR. Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination.
messages: Nucleus
messages: PML body
messages: Sumoylated on lysine residues Lys-449 and Lys-577, with Lys-449 being the major site. Sumoylation promotes recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Desumoylated by SENP6 (By similarity).

9601:OLFM4
gene id: 9601:OLFM4
uniprot id: H2NJZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:STEAP4
gene id: 9601:STEAP4
uniprot id: A0A6D2VTG4
uniprot id: H2PMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9601:ZNF561
gene id: 9601:ZNF561
uniprot id: A0A2J8S1D5
uniprot id: H2NXG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TLE3
gene id: 9601:TLE3
uniprot id: A0A2J8UCE3
uniprot id: A0A2J8UCF3
uniprot id: A0A2J8UCG6
uniprot id: A0A2J8UCH8
uniprot id: A0A2J8UCK1
uniprot id: A0A6D2X8S8
uniprot id: H2NNM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IGLON5
gene id: 9601:IGLON5
uniprot id: H2NZV8
names: Subcellular Location Annotation
messages: Cell membrane

9601:PSMA5
gene id: 9601:PSMA5
uniprot id: A0A2J8UMK1
uniprot id: H2N6I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SV2A
gene id: 9601:SV2A
uniprot id: Q5R4L9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily.
messages: Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).
messages: N-glycosylated.
messages: Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
messages: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
messages: Presynapse
messages: synaptic vesicle membrane

9601:RUFY2
gene id: 9601:RUFY2
uniprot id: A0A2J8WR87
uniprot id: Q5R5R4
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with BMX.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HLTF
gene id: 9601:HLTF
uniprot id: A0A2J8WST2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITPA
gene id: 9601:ITPA
uniprot id: H2P1C9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9601:NOP56
gene id: 9601:NOP56
uniprot id: Q5RA29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP5/NOP56 family.
messages: Cytoplasm
messages: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity).
messages: Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1 (By similarity).
messages: nucleolus
messages: nucleoplasm

9601:NREP
gene id: 9601:NREP
uniprot id: Q5NVD3
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Interacts with FLNA.
messages: May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.
messages: Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

9601:AMN1
gene id: 9601:AMN1
uniprot id: A0A2J8WC35
uniprot id: Q5R8X9
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the AMN1 family.
messages: Interacts with TASOR.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZC2HC1C
gene id: 9601:ZC2HC1C
uniprot id: A0A2J8T3T0
uniprot id: H2NLT9
uniprot id: Q5R498
names: Caution
names: Similarity
messages: Belongs to the ZC2HC1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UGT2A1
gene id: 9601:UGT2A1
uniprot id: H2PDG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9601:TOMM22
gene id: 9601:TOMM22
uniprot id: A0A663DI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9601:DUS1L
gene id: 9601:DUS1L
uniprot id: A0A6D2W9H9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HOXA6
gene id: 9601:HOXA6
uniprot id: H2PMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9601:DEFA4
gene id: 9601:DEFA4
uniprot id: H2PRL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9601:ADAM10
gene id: 9601:ADAM10
uniprot id: Q5R6E8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: adherens junction

9601:LOC100455760
gene id: 9601:LOC100455760
uniprot id: A0A2J8RYS8
uniprot id: Q5R4R8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
messages: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.
messages: nucleolus

9601:LOC100456589
gene id: 9601:LOC100456589
uniprot id: A0A663DH38
uniprot id: H2PI79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:CST6
gene id: 9601:CST6
uniprot id: A0A2J8TZU0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTGER2
gene id: 9601:PTGER2
uniprot id: H2NL90
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:CCL2
gene id: 9601:CCL2
uniprot id: Q5RA36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9601:ZNF215
gene id: 9601:ZNF215
uniprot id: Q5RE50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:AFMID
gene id: 9601:AFMID
uniprot id: A0A6D2X7K8
uniprot id: H2NUW2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:MFSD3
gene id: 9601:MFSD3
uniprot id: H2PRH9
names: Subcellular Location Annotation
messages: Membrane

9601:ZNF22
gene id: 9601:ZNF22
uniprot id: A0A2J8XT63
uniprot id: Q5R4X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100449961
gene id: 9601:LOC100449961
uniprot id: A0A2J8UVW1
names: Caution
names: Similarity
messages: Belongs to the apolipoprotein L family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LRWD1
gene id: 9601:LRWD1
uniprot id: H2PLT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9601:CCL27
gene id: 9601:CCL27
uniprot id: H2PRV7
names: Subcellular Location Annotation
messages: Secreted

9601:PYROXD1
gene id: 9601:PYROXD1
uniprot id: Q5REJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity).
messages: sarcomere

9601:DRD3
gene id: 9601:DRD3
uniprot id: A0A2J8W2H0
uniprot id: H2P9P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9601:AHCYL2
gene id: 9601:AHCYL2
uniprot id: Q5R889
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Homotetramer. Forms heteromultimers with AHCYL1 (via the C-terminal region). Interacts with ITPR1; with lower affinity than AHCYL1 and maybe via ITPR1. Interacts with SLC4A4. Interacts with ZCCHC4 (By similarity).
messages: May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate.
messages: Microsome

9601:TMBIM6
gene id: 9601:TMBIM6
uniprot id: A0A2J8SYE8
uniprot id: Q5R7R1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BI1 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with BCL2. Interacts with BCL2L1.
messages: Membrane
messages: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
messages: The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNAB3
gene id: 9601:KCNAB3
uniprot id: H2NSL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9601:CALHM6
gene id: 9601:CALHM6
uniprot id: A0A2J8U146
uniprot id: A0A663DHN8
uniprot id: H2PK50
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HINT2
gene id: 9601:HINT2
uniprot id: H2PRR9
names: Similarity
messages: Belongs to the HINT family.

9601:VMA21
gene id: 9601:VMA21
uniprot id: A0A2J8S439
uniprot id: Q5RDV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase) (By similarity). Interacts with ATP6AP2 (By similarity).
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNOT6L
gene id: 9601:CNOT6L
uniprot id: Q5REP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9601:GJA5
gene id: 9601:GJA5
uniprot id: A0A2J8XT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:KIF11
gene id: 9601:KIF11
uniprot id: H2NB08
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9601:RPS26
gene id: 9601:RPS26
uniprot id: A0A6D2W6A2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9601:TPX2
gene id: 9601:TPX2
uniprot id: A0A663DBM9
uniprot id: H2P1K4
uniprot id: Q5RAF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPX2 family.
messages: Interacts with AURKA (By similarity). Interacts with importin-alpha; leading to inactivate TPX2 (By similarity). Interacts with HNRNPU; this interaction recruits HNRNPU to spindle microtubules (MTs) (By similarity). Interacts with BCL2L10 (By similarity).
messages: Nucleus
messages: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle
messages: spindle pole

9601:SYP
gene id: 9601:SYP
uniprot id: A0A6D2WKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9601:DHX40
gene id: 9601:DHX40
uniprot id: Q5R864
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Probable ATP-dependent RNA helicase.

9601:ZNF34
gene id: 9601:ZNF34
uniprot id: H2PRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:ARRDC5
gene id: 9601:ARRDC5
uniprot id: A0A6D2VUJ4
uniprot id: H2NX44
names: Caution
names: Similarity
messages: Belongs to the arrestin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FKBP7
gene id: 9601:FKBP7
uniprot id: Q5RET2
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Binds calcium.
messages: Endoplasmic reticulum lumen
messages: Glycosylated.
messages: PPIases accelerate the folding of proteins during protein synthesis.

9601:SLAIN1
gene id: 9601:SLAIN1
uniprot id: Q5R6Z0
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9601:FKBP1B
gene id: 9601:FKBP1B
uniprot id: A0A2J8VMD5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRMT1L
gene id: 9601:TRMT1L
uniprot id: Q5R5T0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9601:TTC27
gene id: 9601:TTC27
uniprot id: Q5RBW9
names: Similarity
messages: Belongs to the TTC27 family.

9601:TFAP2D
gene id: 9601:TFAP2D
uniprot id: H2PJC0
names: Similarity
messages: Belongs to the AP-2 family.

9601:SLC28A2
gene id: 9601:SLC28A2
uniprot id: H2NN47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9601:TADA1
gene id: 9601:TADA1
uniprot id: A0A2J8SAN4
uniprot id: Q5RDB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HSPB6
gene id: 9601:HSPB6
uniprot id: A0A2J8RRR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCL20
gene id: 9601:CCL20
uniprot id: A0A2J8SHS1
uniprot id: K7ESX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAF8
gene id: 9601:TAF8
uniprot id: A0A6D2WYH6
uniprot id: H2PJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9601:GCSH
gene id: 9601:GCSH
uniprot id: H2NRK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9601:SLC1A4
gene id: 9601:SLC1A4
uniprot id: A0A663DHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9601:SMIM7
gene id: 9601:SMIM7
uniprot id: A0A8I5YNP0
uniprot id: H2NXY8
names: Similarity
messages: Belongs to the SMIM7 family.

9601:NPY2R
gene id: 9601:NPY2R
uniprot id: A0A6D2XUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ORC3
gene id: 9601:ORC3
uniprot id: A0A663D8I3
uniprot id: H2PJS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100437798
gene id: 9601:LOC100437798
uniprot id: H2NED3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:FAM241B
gene id: 9601:FAM241B
uniprot id: A0A663D826
uniprot id: H2NAP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SKIL
gene id: 9601:SKIL
uniprot id: A0A2J8TIP0
uniprot id: Q5R431
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the SKI family.
messages: Interacts with CPNE4 (via VWFA domain). Interacts with SMAD2, SMAD3 and RNF111. Interacts with WWP1.
messages: May have regulatory role in cell division or differentiation in response to extracellular signals.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.

9601:CCDC85B
gene id: 9601:CCDC85B
uniprot id: H2NCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9601:ZFP92
gene id: 9601:ZFP92
uniprot id: A0A663DC65
uniprot id: H2PX48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PEX12
gene id: 9601:PEX12
uniprot id: A0A6D2VTT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9601:LOC100452627
gene id: 9601:LOC100452627
uniprot id: A0A663DIN0
names: Similarity
messages: Belongs to the FMC1 family.

9601:PSMF1
gene id: 9601:PSMF1
uniprot id: A0A2J8VI89
uniprot id: A0A2J8VI95
uniprot id: Q5RDN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer and homodimer. Interacts with FBXO7 (By similarity).
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATF6B
gene id: 9601:ATF6B
uniprot id: A0A803KKZ8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SH3GLB1
gene id: 9601:SH3GLB1
uniprot id: Q5R8P5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Homodimer, and heterodimer with SH3GLB2. Binds BAX; induction of apoptosis augments BAX binding. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Interacts with UVRAG; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex II (PI3KC3-C2) STOPPED Homodimer, and heterodimer with SH3GLB2. Binds BAX. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity).
messages: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
messages: Midbody
messages: Mitochondrion outer membrane
messages: Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
messages: The SH3 domain is required and sufficient for the interaction with UVRAG.
messages: autophagosome membrane

9601:BTG1
gene id: 9601:BTG1
uniprot id: A0A663D9G1
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

9601:ID2
gene id: 9601:ID2
uniprot id: A0A2J8V3T9
uniprot id: Q5RCH7
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GATA4 and NKX2-5 (By similarity). Interacts with NR0B2 (By similarity). Interacts with CLOCK and BMAL1 (By similarity). Interacts with IFI204 (By similarity). Interacts with NEDD9/HEF1 (By similarity).
messages: Nucleus
messages: The bHLH domain is essential for its repressor activity towards the CLOCK-BMAL1 heterodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).

9601:CYBRD1
gene id: 9601:CYBRD1
uniprot id: Q5RAJ4
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Binds 2 heme b groups non-covalently.
messages: Cell membrane
messages: Homodimer.
messages: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (By similarity).

9601:CHD2
gene id: 9601:CHD2
uniprot id: Q5RCL9
names: Subcellular Location Annotation
messages: Nucleus

9601:PPBP
gene id: 9601:PPBP
uniprot id: H2PDL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:CHMP7
gene id: 9601:CHMP7
uniprot id: Q5R812
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity). Recruited to the reforming NE during anaphase by LEMD2 (By similarity). Plays a role in the endosomal sorting pathway (By similarity).
messages: Interacts with CHMP4B, but not with VPS25 (By similarity). Interacts with LEMD2 (via C-terminus) (By similarity).
messages: Nucleus envelope

9601:RPL8
gene id: 9601:RPL8
uniprot id: Q5R7Y8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with CRY1 (By similarity).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.

9601:SYBU
gene id: 9601:SYBU
uniprot id: A0A2J8X361
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NAGLU
gene id: 9601:NAGLU
uniprot id: H2NU02
names: Subcellular Location Annotation
messages: Lysosome

9601:ZNF625
gene id: 9601:ZNF625
uniprot id: K7ESV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:TRIM44
gene id: 9601:TRIM44
uniprot id: A0A2J8WFS7
uniprot id: Q5R846
names: Caution
names: Function
names: Subunit
messages: Interacts (via coiled coil) with TRIM17 (via coiled coil).
messages: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BTF3L4
gene id: 9601:BTF3L4
uniprot id: A0A2J8V8P0
uniprot id: Q5RC59
names: Caution
names: Similarity
messages: Belongs to the NAC-beta family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TPMT
gene id: 9601:TPMT
uniprot id: A0A6D2Y5J2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9601:FADS2
gene id: 9601:FADS2
uniprot id: A0A2J8SMN3
uniprot id: Q5REA7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).
messages: The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM96B
gene id: 9601:FAM96B
uniprot id: H2NR53
names: Similarity
messages: Belongs to the MIP18 family.

9601:C2CD5
gene id: 9601:C2CD5
uniprot id: Q5RDC8
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.
messages: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
messages: The C2 domain binds to calcium and membrane lipids.
messages: cell cortex
messages: ruffle

9601:LOC100445071
gene id: 9601:LOC100445071
uniprot id: A0A6D2W1V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.
messages: Nucleus

9601:RPL23
gene id: 9601:RPL23
uniprot id: Q5REU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9601:HJV
gene id: 9601:HJV
uniprot id: H2N620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9601:PRKAA2
gene id: 9601:PRKAA2
uniprot id: Q5RD00
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Interacts with DUSP29 (By similarity).
messages: Activated by phosphorylation on Thr-172. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-172. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-172. ADP also stimulates Thr-172 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-172, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. Salicylate/aspirin directly activates kinase activity, primarily by inhibiting Thr-172 dephosphorylation (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negat…
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK (By similarity). Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1) (By similarity).
messages: The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
messages: Ubiquitinated.

9601:AURKB
gene id: 9601:AURKB
uniprot id: A0A6D2X0D3
uniprot id: H2NSM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centromere

9601:FAU
gene id: 9601:FAU
uniprot id: P0C2F1
names: Miscellaneous
names: Similarity
messages: Belongs to the ubiquitin family.
messages: This protein is synthesized with ribosomal S30 as its C-terminal extension.

9601:MAPK13
gene id: 9601:MAPK13
uniprot id: H2PIU8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9601:PLAGL1
gene id: 9601:PLAGL1
uniprot id: A0A2J8XA30
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WNT3A
gene id: 9601:WNT3A
uniprot id: H2N3H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9601:ALDH5A1
gene id: 9601:ALDH5A1
uniprot id: H2PI26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9601:C5H5orf15
gene id: 9601:C5H5orf15
uniprot id: Q5R5B8
names: Subcellular Location Annotation
messages: Membrane

9601:PLAT
gene id: 9601:PLAT
uniprot id: Q5R8J0
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Both FN1 and EGF-like domains are important for binding to LRP1.
messages: Both FN1 and one of the kringle domains are required for binding to fibrin.
messages: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.
messages: Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation. Forms heterodimer with SERPINA5 (By similarity). In complex with SERPINE1, interacts with SORL1 (By similarity).
messages: Inhibited by SERPINA5.
messages: The FN1 domain mediates binding to annexin A2.
messages: The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.
messages: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
messages: extracellular space

9601:RNASE4
gene id: 9601:RNASE4
uniprot id: A0A663DIH0
uniprot id: Q5NVS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted
messages: This RNase has marked specificity towards the 3' side of uridine nucleotides.

9601:SELENOP
gene id: 9601:SELENOP
uniprot id: Q5R8W9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis (By similarity).
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted
messages: The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.

9601:CDC42BPG
gene id: 9601:CDC42BPG
uniprot id: H2NCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9601:TEX10
gene id: 9601:TEX10
uniprot id: H2PSW5
uniprot id: Q5RDK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Cytoplasm
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

9601:LOC100457433
gene id: 9601:LOC100457433
uniprot id: H2P2C1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:PGK2
gene id: 9601:PGK2
uniprot id: H2PJB3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9601:COX6A2
gene id: 9601:COX6A2
uniprot id: A0A2J8TKU3
uniprot id: Q5RC38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCDC125
gene id: 9601:CCDC125
uniprot id: A0A2J8VTR8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AR
gene id: 9601:AR
uniprot id: A0A2J8UBB2
uniprot id: Q5RFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9601:STRA6
gene id: 9601:STRA6
uniprot id: Q5R7B4
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Contrary to predictions, contains nine transmembrane helices, with an extracellular N-terminus and a cytoplasmic C-terminus (By similarity). Besides, contains one long helix that dips into the membrane and then runs more or less parallel to the membrane surface (By similarity).
messages: Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
messages: Homodimer (By similarity). Interacts with JAK2 and STAT5. Interacts (via extracellular domains) with RBP4. Interacts (via cytoplasmic domains) with RBP1 (By similarity).
messages: Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules.

9601:LOC100441148
gene id: 9601:LOC100441148
uniprot id: A0A6D2WKJ8
uniprot id: H2NWI2
names: Similarity
messages: Belongs to the serpin family.

9601:PHC3
gene id: 9601:PHC3
uniprot id: A0A2J8TIC7
uniprot id: A0A663D907
uniprot id: H2PBZ0
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COX7A2L
gene id: 9601:COX7A2L
uniprot id: A0A6D2W3R2
uniprot id: Q5RDM8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9601:PUM2
gene id: 9601:PUM2
uniprot id: A0A6D2VSD5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LDHA
gene id: 9601:LDHA
uniprot id: Q5R5F0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31.
messages: ISGylated.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

9601:TBX15
gene id: 9601:TBX15
uniprot id: A0A6D2WET8
uniprot id: H2N668
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CD300LF
gene id: 9601:CD300LF
uniprot id: A0A2J8Y080
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DCTN4
gene id: 9601:DCTN4
uniprot id: Q5R7U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 4 family.
messages: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (By similarity).
messages: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres.
messages: cell cortex
messages: centrosome
messages: cytoskeleton
messages: sarcomere
messages: stress fiber

9601:ABAT
gene id: 9601:ABAT
uniprot id: Q5RDB7
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9601:MED20
gene id: 9601:MED20
uniprot id: H2PJ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9601:NECAB1
gene id: 9601:NECAB1
uniprot id: A0A2J8UG21
uniprot id: Q5R467
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with STX1. May interact with CPNE6.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDX1
gene id: 9601:CDX1
uniprot id: H2PH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9601:APH1B
gene id: 9601:APH1B
uniprot id: A0A2J8T8H1
uniprot id: A0A2J8T8J1
uniprot id: Q5RDM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.
messages: Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with PSEN1 and PSEN2 (By similarity).
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EPHX2
gene id: 9601:EPHX2
uniprot id: A0A663D7D3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEC22C
gene id: 9601:SEC22C
uniprot id: A0A663DI63
uniprot id: A0A6D2WJ39
uniprot id: K7ETA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NLGN4X
gene id: 9601:NLGN4X
uniprot id: Q5R734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9601:RSPO4
gene id: 9601:RSPO4
uniprot id: H2P1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9601:DNASE1L3
gene id: 9601:DNASE1L3
uniprot id: H2PAE7
names: Similarity
messages: Belongs to the DNase I family.

9601:HERPUD1
gene id: 9601:HERPUD1
uniprot id: A0A2J8VYX3
uniprot id: Q5R5B0
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
messages: Endoplasmic reticulum membrane
messages: Interacts with PSEN1 and PSEN2 (By similarity). Interacts with UBXN6 (By similarity). Interacts with UBQLN1, UBQLN2 and UBQLN4 (By similarity). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. FAM8A1 binding to SYNV1 may promote recruitment of HERPUD1 to the HRD1 complex (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC22A6
gene id: 9601:SLC22A6
uniprot id: A0A2J8TY62
uniprot id: A0A2J8TY65
uniprot id: A0A2J8TY71
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GIMAP6
gene id: 9601:GIMAP6
uniprot id: A0A2J8RK58
uniprot id: A0A663DBZ4
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RIPPLY3
gene id: 9601:RIPPLY3
uniprot id: A0A6D2XV87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9601:LOC100443682
gene id: 9601:LOC100443682
uniprot id: H2PL23
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane

9601:POMP
gene id: 9601:POMP
uniprot id: A0A2J8UTD1
uniprot id: Q5R9L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POMP/UMP1 family.
messages: Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i is controversial. Forms tetramers (By similarity).
messages: Microsome membrane
messages: Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:BOLL
gene id: 9601:BOLL
uniprot id: A0A2J8WVG3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CRLS1
gene id: 9601:CRLS1
uniprot id: H2P0Z8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9601:CYP4F11
gene id: 9601:CYP4F11
uniprot id: Q5RDY6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:ATP6V1B2
gene id: 9601:ATP6V1B2
uniprot id: A0A2J8X4A2
uniprot id: Q5R5V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cytoplasm
messages: Melanosome
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity).
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9601:APH1A
gene id: 9601:APH1A
uniprot id: A0A2J8VEK3
uniprot id: H2N601
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9601:OCRL
gene id: 9601:OCRL
uniprot id: Q5R9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9601:MARK1
gene id: 9601:MARK1
uniprot id: A0A2J8U2I4
uniprot id: A0A6D2X690
uniprot id: H2N3N7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: dendrite

9601:DYM
gene id: 9601:DYM
uniprot id: Q5RAW5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dymeclin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts with GOLM1 and PPIB.
messages: Membrane
messages: Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.
messages: Necessary for correct organization of Golgi apparatus. Involved in bone development.

9601:ADA2
gene id: 9601:ADA2
uniprot id: Q5RC46
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity).
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Binds 1 zinc ion per subunit.
messages: High-affinity binding to heparin/glycosaminoclycan (GAG) is mediated by a large, highly positively charged surface at the interface of dimer's subunits involving approximately residues 30-45, 389-396, and 422-428.
messages: Homodimer. Interacts with adenosine receptors. Binds heparin (By similarity).
messages: Secreted
messages: The PRB domain is involved in receptor binding, and may be responsible for the cytokine-like growth factor activity due to it's sharing of several structural properties with chemokines.

9601:FOXR1
gene id: 9601:FOXR1
uniprot id: H2NFI7
names: Subcellular Location Annotation
messages: Nucleus

9601:CDK2AP2
gene id: 9601:CDK2AP2
uniprot id: H2NCM7
names: Similarity
messages: Belongs to the CDK2AP family.

9601:SRSF11
gene id: 9601:SRSF11
uniprot id: A0A2J8WPY3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HYAL2
gene id: 9601:HYAL2
uniprot id: A0A6D2W2B9
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9601:CXCR3
gene id: 9601:CXCR3
uniprot id: A0A2J8UBM1
uniprot id: H2PW02
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100454300
gene id: 9601:LOC100454300
uniprot id: H2PWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9601:SPSB2
gene id: 9601:SPSB2
uniprot id: A0A2J8TBH5
uniprot id: A0A6D2XUY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AHR
gene id: 9601:AHR
uniprot id: A0A8I5UR06
uniprot id: H2PMR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:EBP
gene id: 9601:EBP
uniprot id: Q5RAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:THSD1
gene id: 9601:THSD1
uniprot id: Q5R7R7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
messages: Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL. Interacts with TLN1.
messages: focal adhesion

9601:LOC100440513
gene id: 9601:LOC100440513
uniprot id: H2NPY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ITPKB
gene id: 9601:ITPKB
uniprot id: A0A6D2X1S5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9601:CAV2
gene id: 9601:CAV2
uniprot id: A0A2J8UPI9
uniprot id: A0A2J8UPJ8
uniprot id: Q2IBD6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
messages: Membrane
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: caveola

9601:RNF34
gene id: 9601:RNF34
uniprot id: A0A2J8XJS2
uniprot id: Q5NVC7
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated (in vitro).
messages: Cell membrane
messages: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
messages: Endomembrane system
messages: Interacts with CASP8 and CASP10. Interacts with p53/TP53; involved in p53/TP53 ubiquitination. Interacts (via RING-type zinc finger) with MDM2; the interaction stabilizes MDM2. Interacts (via RING-type zinc finger) with PPARGC1A. Interacts with NOD1.
messages: Nucleus
messages: Nucleus speckle
messages: Proteolytically cleaved by caspases upon induction of apoptosis by TNF.
messages: The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids.
messages: The RING-type zinc finger is required for the ubiquitination of target proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:SLX4
gene id: 9601:SLX4
uniprot id: H2NPZ5
names: Similarity
messages: Belongs to the SLX4 family.

9601:TSPAN31
gene id: 9601:TSPAN31
uniprot id: A0A2J8UGV8
uniprot id: Q5RAP8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPS7
gene id: 9601:MRPS7
uniprot id: H2NUP6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9601:TOR1AIP1
gene id: 9601:TOR1AIP1
uniprot id: A0A2J8V7V7
uniprot id: A0A2J8V7W2
uniprot id: Q5R7A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOR1AIP family.
messages: Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A (By similarity).
messages: Membrane
messages: Nucleus inner membrane
messages: Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SVIP
gene id: 9601:SVIP
uniprot id: A0A2J8STX7
uniprot id: Q5R6N0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SVIP family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with VCP.
messages: Membrane
messages: Smooth endoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100445915
gene id: 9601:LOC100445915
uniprot id: H2NTY1
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9601:ANAPC5
gene id: 9601:ANAPC5
uniprot id: A0A2J8XJT0
uniprot id: A0A2J8XJV7
uniprot id: Q5RE52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Nucleus
messages: The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle

9601:ATP2A3
gene id: 9601:ATP2A3
uniprot id: A0A2J8SPE7
uniprot id: A0A2J8SPG3
uniprot id: A0A2J8SPH8
uniprot id: H2NSA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASNS
gene id: 9601:ASNS
uniprot id: A0A2J8WJI1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM129A
gene id: 9601:FAM129A
uniprot id: H2N4E3
names: Similarity
messages: Belongs to the Niban family.

9601:WDR18
gene id: 9601:WDR18
uniprot id: H2NWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
messages: nucleolus
messages: nucleoplasm

9601:TMEM50A
gene id: 9601:TMEM50A
uniprot id: Q5RA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9601:TM4SF20
gene id: 9601:TM4SF20
uniprot id: H2P8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9601:LOC100442730
gene id: 9601:LOC100442730
uniprot id: H2NVR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9601:CAP2
gene id: 9601:CAP2
uniprot id: H2PI04
uniprot id: Q5R5X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: May have a regulatory bifunctional role.
messages: Membrane

9601:SERPINA10
gene id: 9601:SERPINA10
uniprot id: A0A2J8TLS8
uniprot id: A0A6D2XGY7
uniprot id: Q5RDA8
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
messages: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9601:HDHD2
gene id: 9601:HDHD2
uniprot id: Q5R4B4
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Binds 1 Mg(2+) ion per subunit.

9601:NTRK1
gene id: 9601:NTRK1
uniprot id: H2N5B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9601:TMC3
gene id: 9601:TMC3
uniprot id: A0A2J8SKQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SIAH1
gene id: 9601:SIAH1
uniprot id: A0A663D867
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9601:RAB14
gene id: 9601:RAB14
uniprot id: A0A2J8WRF7
uniprot id: Q5R8Z8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).
messages: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity).
messages: Recycling endosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: phagosome
messages: trans-Golgi network membrane

9601:NUDCD1
gene id: 9601:NUDCD1
uniprot id: H2PR14
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:RBBP5
gene id: 9601:RBBP5
uniprot id: A0A2J8V738
uniprot id: H2N408
uniprot id: Q5R7E1
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TOPORS
gene id: 9601:TOPORS
uniprot id: A0A2J8XIP0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF616
gene id: 9601:ZNF616
uniprot id: H2NZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:RAB1B
gene id: 9601:RAB1B
uniprot id: A0A2J8TZX0
uniprot id: Q5RE13
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Interacts with MICAL1 and MICAL2. Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II. Interacts with RabGAP TBC1D20. Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). Interacts (in GDP-bound form) with lipid phosphatase MTMR7 (By similarity).
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
messages: Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
messages: perinuclear region

9601:LOC100450954
gene id: 9601:LOC100450954
uniprot id: A0A6D2Y4F6
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9601:DLX6
gene id: 9601:DLX6
uniprot id: H2PMV2
names: Subcellular Location Annotation
messages: Nucleus

9601:POLL
gene id: 9601:POLL
uniprot id: A0A6D2WLI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9601:AMHR2
gene id: 9601:AMHR2
uniprot id: A0A2J8SX59
uniprot id: H2NHH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PDE7B
gene id: 9601:PDE7B
uniprot id: A0A2J8X9H7
uniprot id: H2PKE4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9601:TMEM126A
gene id: 9601:TMEM126A
uniprot id: A0A2J8S9Q8
uniprot id: A0A2J8S9S3
uniprot id: Q5RAY9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM126 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP5MGL
gene id: 9601:ATP5MGL
uniprot id: A0A2J8TWG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLAA
gene id: 9601:PLAA
uniprot id: H2PS06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9601:LOC100431205
gene id: 9601:LOC100431205
uniprot id: H2N6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9601:HMGCS1
gene id: 9601:HMGCS1
uniprot id: A0A2J8SA59
uniprot id: Q5R7Z9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
messages: Cytoplasm
messages: Homodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPP4R4
gene id: 9601:PPP4R4
uniprot id: A0A2J8TLM3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CRCP
gene id: 9601:CRCP
uniprot id: A0A2J8R8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9601:OSBPL9
gene id: 9601:OSBPL9
uniprot id: A0A2J8V8K6
uniprot id: A0A2J8V8L5
uniprot id: A0A2J8V8L8
uniprot id: Q5R9W4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Heterodimer with OSBPL11. Interacts with OSBPL10.
messages: Late endosome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: trans-Golgi network membrane

9601:IL1B
gene id: 9601:IL1B
uniprot id: H2P5G2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9601:LIPA
gene id: 9601:LIPA
uniprot id: H2NAY2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9601:PDCL3
gene id: 9601:PDCL3
uniprot id: Q5RB77
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).
messages: Belongs to the phosducin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (By similarity). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (By similarity). Interacts with XIAP (via BIR 3 and RING domain) (By similarity). Interacts with HSP90AA1 and HSP90AB1 (By similarity).
messages: N-terminal methionine acetylation destabilizes the protein.
messages: perinuclear region

9601:TAF1B
gene id: 9601:TAF1B
uniprot id: H2P700
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9601:GTPBP2
gene id: 9601:GTPBP2
uniprot id: A0A2J8Y4R1
uniprot id: A0A6D2XLF2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SAP30L
gene id: 9601:SAP30L
uniprot id: H2PH57
names: Similarity
messages: Belongs to the SAP30 family.

9601:RTRAF
gene id: 9601:RTRAF
uniprot id: A0A2J8WKN6
uniprot id: Q5R8I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RTRAF family.
messages: Homodimer. Interacts with FAM98A (via N- and C-terminus). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex.
messages: Nucleus
messages: RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: cytosol
messages: perinuclear region

9601:EIF3C
gene id: 9601:EIF3C
uniprot id: Q5RAT8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3 (By similarity). Interacts with ALKBH4, IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9601:TRIM56
gene id: 9601:TRIM56
uniprot id: H2PLR5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9601:LHX3
gene id: 9601:LHX3
uniprot id: H2PTY1
names: Subcellular Location Annotation
messages: Nucleus

9601:FRZB
gene id: 9601:FRZB
uniprot id: A0A2J8RZ32
uniprot id: Q5RF67
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Interacts with MYOC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
messages: The FZ domain is involved in binding with Wnt ligands.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EXOC3L1
gene id: 9601:EXOC3L1
uniprot id: H2NR64
names: Similarity
messages: Belongs to the SEC6 family.

9601:STEAP2
gene id: 9601:STEAP2
uniprot id: A0A2J8WK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9601:OLR1
gene id: 9601:OLR1
uniprot id: A0A6D2X6V2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLPX
gene id: 9601:CLPX
uniprot id: H2NNI3
names: Similarity
messages: Belongs to the ClpX chaperone family.

9601:CNOT9
gene id: 9601:CNOT9
uniprot id: A0A2J8TU22
uniprot id: Q5R6Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT9 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation.
messages: Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA. Interacts with NANOS2. Directly interacts with ZNF335 (By similarity).
messages: Nucleus
messages: P-body

9601:WDR72
gene id: 9601:WDR72
uniprot id: Q5RFQ4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.

9601:MYOT
gene id: 9601:MYOT
uniprot id: A0A2J8VQ05
uniprot id: A0A2J8VQ32
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MOB3B
gene id: 9601:MOB3B
uniprot id: H2PRZ7
names: Similarity
messages: Belongs to the MOB1/phocein family.

9601:IFNA6
gene id: 9601:IFNA6
uniprot id: H2PS20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:LOC100456655
gene id: 9601:LOC100456655
uniprot id: H2NQC9
names: Similarity
messages: Belongs to the peptidase M16 family.

9601:PHB
gene id: 9601:PHB
uniprot id: A0A6D2VX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9601:RPL39
gene id: 9601:RPL39
uniprot id: A0A663D5Z9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9601:PLK4
gene id: 9601:PLK4
uniprot id: Q5R9Z7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: Cryptic POLO box 1 (CPB1) and Cryptic POLO box 2 (CPB2) domains can simultaneously bind to both TENT5C and CEP192.
messages: Homodimer (By similarity). Interacts with CEP152 (via N-terminus) (By similarity). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (By similarity). Interacts with CEP131 (By similarity). Interacts simultaneously with TENT5C and CEP192. Interacts with TENT5C; this interaction leads to the TENT5C recruitment in the centrosome (By similarity).
messages: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity).
messages: Tyrosine-phosphorylated by TEC.
messages: Ubiquitinated; leading to its degradation by the proteasome.
messages: centriole
messages: centrosome
messages: nucleolus

9601:FAM20B
gene id: 9601:FAM20B
uniprot id: H2N4J8
names: Similarity
messages: Belongs to the FAM20 family.

9601:GLS2
gene id: 9601:GLS2
uniprot id: H2NHQ6
names: Similarity
messages: Belongs to the glutaminase family.

9601:RPS28
gene id: 9601:RPS28
uniprot id: H2NAH2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

9601:L2HGDH
gene id: 9601:L2HGDH
uniprot id: Q5R9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L2HGDH family.
messages: Mitochondrion

9601:ATP5PD
gene id: 9601:ATP5PD
uniprot id: H2NUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9601:ISLR
gene id: 9601:ISLR
uniprot id: Q5NVQ6
names: Subcellular Location Annotation
messages: Secreted

9601:LOC100461659
gene id: 9601:LOC100461659
uniprot id: A0A6D2W1K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PLEKHO1
gene id: 9601:PLEKHO1
uniprot id: A0A663D6C9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:NUTM2F
gene id: 9601:NUTM2F
uniprot id: H2PSR5
names: Similarity
messages: Belongs to the NUT family.

9601:TREX2
gene id: 9601:TREX2
uniprot id: A0A6D2Y012
names: Caution
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PNCK
gene id: 9601:PNCK
uniprot id: A0A2J8RLE0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:MFSD5
gene id: 9601:MFSD5
uniprot id: Q5R542
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

9601:GTSF1L
gene id: 9601:GTSF1L
uniprot id: A0A6D2WFC3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADGRF4
gene id: 9601:ADGRF4
uniprot id: A0A2J8RKU8
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GUCA2A
gene id: 9601:GUCA2A
uniprot id: H2N7S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9601:SLC25A34
gene id: 9601:SLC25A34
uniprot id: A0A2J8S914
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:TTC4
gene id: 9601:TTC4
uniprot id: Q5NVA7
names: Similarity
messages: Belongs to the TTC4 family.

9601:ANKZF1
gene id: 9601:ANKZF1
uniprot id: A0A2J8TUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9601:LOC100453729
gene id: 9601:LOC100453729
uniprot id: A0A663D5E1
uniprot id: H2NDB2
names: Caution
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HIGD1C
gene id: 9601:HIGD1C
uniprot id: A0A2J8SY09
names: Caution
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTG2
gene id: 9601:MTG2
uniprot id: A0A2J8TX64
uniprot id: Q5RDW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:YAE1D1
gene id: 9601:YAE1D1
uniprot id: A0A663DIN3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:SGK3
gene id: 9601:SGK3
uniprot id: A0A2J8UR60
uniprot id: Q5R7A7
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.
messages: Recycling endosome
messages: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.

9601:EXOC4
gene id: 9601:EXOC4
uniprot id: Q5RDN1
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9601:SEMA7A
gene id: 9601:SEMA7A
uniprot id: H2NNR6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:FOXE1
gene id: 9601:FOXE1
uniprot id: H2PSU7
names: Subcellular Location Annotation
messages: Nucleus

9601:TPD52L3
gene id: 9601:TPD52L3
uniprot id: A0A2J8XI59
uniprot id: H2PS68
names: Caution
names: Similarity
messages: Belongs to the TPD52 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TM6SF1
gene id: 9601:TM6SF1
uniprot id: Q5RBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Lysosome membrane
messages: May function as sterol isomerase.

9601:GNL2
gene id: 9601:GNL2
uniprot id: Q5RET1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9601:ASB7
gene id: 9601:ASB7
uniprot id: Q5RCK5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: Interacts with CUL5 and RNF7.
messages: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.

9601:HSD17B11
gene id: 9601:HSD17B11
uniprot id: Q5NVG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity).
messages: Endoplasmic reticulum
messages: Lipid droplet

9601:LOC100446987
gene id: 9601:LOC100446987
uniprot id: A0A2J8SW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:NDUFA5
gene id: 9601:NDUFA5
uniprot id: H2PND0
uniprot id: P0CB99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:LTB4R
gene id: 9601:LTB4R
uniprot id: A0A6D2W1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ODC1
gene id: 9601:ODC1
uniprot id: A0A6D2W4P3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9601:GLYAT
gene id: 9601:GLYAT
uniprot id: Q5RFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycine N-acyltransferase family.
messages: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
messages: Mitochondrion

9601:LOC100434899
gene id: 9601:LOC100434899
uniprot id: A0A2J8RUE6
uniprot id: A0A2J8RUF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:TFEB
gene id: 9601:TFEB
uniprot id: A0A2J8Y462
uniprot id: H2PJ06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LRRC8A
gene id: 9601:LRRC8A
uniprot id: A0A6D2WZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9601:POLR1B
gene id: 9601:POLR1B
uniprot id: Q5REE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Chromosome
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
messages: nucleolus

9601:S1PR4
gene id: 9601:S1PR4
uniprot id: H2NWZ1
names: Subcellular Location Annotation
messages: Membrane

9601:KCNA4
gene id: 9601:KCNA4
uniprot id: Q5REB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9601:ELOVL5
gene id: 9601:ELOVL5
uniprot id: A0A2J8SSL0
uniprot id: A0A8I5T2C7
uniprot id: H2PJE0
uniprot id: Q5RFL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: dendrite

9601:ADH7
gene id: 9601:ADH7
uniprot id: H2PDY7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9601:CSRNP3
gene id: 9601:CSRNP3
uniprot id: A0A6D2X339
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9601:TIMP3
gene id: 9601:TIMP3
uniprot id: A0A663D5M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9601:SBDS
gene id: 9601:SBDS
uniprot id: A0A2J8T1Y7
uniprot id: Q5RAZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex consisting of the 60S ribosomal subunit, SBDS and EFL1. Interacts with CLN3 (By similarity).
messages: Belongs to the SDO1/SBDS family.
messages: Cytoplasm
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus
messages: nucleoplasm
messages: spindle

9601:LOC100451317
gene id: 9601:LOC100451317
uniprot id: A0A6D2XHJ9
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9601:ATG13
gene id: 9601:ATG13
uniprot id: A0A2J8WF62
uniprot id: A0A2J8WF74
uniprot id: A0A2J8WF93
uniprot id: Q5RE28
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus). Interacts (via the LIR motif) with GABARAP, GABARAPL, GABARAPL2, and LC3A. Interacts with TAB2 and TAB3. Interacts with C9orf72.
messages: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
messages: Preautophagosomal structure
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:TFIP11
gene id: 9601:TFIP11
uniprot id: Q5R5K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Nucleus

9601:ALDH9A1
gene id: 9601:ALDH9A1
uniprot id: Q5R8A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
messages: Homotetramer.
messages: cytosol

9601:NLN
gene id: 9601:NLN
uniprot id: Q5R9V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
messages: Mitochondrion intermembrane space
messages: cytosol

9601:SPTY2D1
gene id: 9601:SPTY2D1
uniprot id: H2NDX5
names: Similarity
messages: Belongs to the SPT2 family.

9601:LOC100436861
gene id: 9601:LOC100436861
uniprot id: H2NS88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:KRT23
gene id: 9601:KRT23
uniprot id: A0A2J8WAL2
names: Caution
names: Similarity
messages: Belongs to the intermediate filament family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZDHHC9
gene id: 9601:ZDHHC9
uniprot id: Q5R5J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with GOLGA7.
messages: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
messages: The DHHC domain is required for palmitoyltransferase activity.

9601:CNOT10
gene id: 9601:CNOT10
uniprot id: H2PB90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9601:PDSS1
gene id: 9601:PDSS1
uniprot id: H2NA05
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9601:COPS7B
gene id: 9601:COPS7B
uniprot id: A0A2J8TQ54
uniprot id: A0A6D2X9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9601:GNPNAT1
gene id: 9601:GNPNAT1
uniprot id: Q5RAL9
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Endosome membrane
messages: Erroneous pre-mRNA splicing.
messages: Golgi apparatus membrane
messages: Homodimer.

9601:EMP2
gene id: 9601:EMP2
uniprot id: A0A6D2W230
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: perinuclear region

9601:IPO8
gene id: 9601:IPO8
uniprot id: A0A2J8WBZ4
uniprot id: A0A8I5TVG1
names: Subcellular Location Annotation
messages: Cytoplasm

9601:PAQR4
gene id: 9601:PAQR4
uniprot id: A0A6D2X697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9601:LOC100455523
gene id: 9601:LOC100455523
uniprot id: H2PWQ1
names: Similarity
messages: Belongs to the actin family.

9601:UFM1
gene id: 9601:UFM1
uniprot id: Q5R4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with UBA5. Interacts with UFC1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.

9601:CETN1
gene id: 9601:CETN1
uniprot id: H2NW00
names: Similarity
messages: Belongs to the centrin family.

9601:DDX54
gene id: 9601:DDX54
uniprot id: H2NIR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9601:HPCAL1
gene id: 9601:HPCAL1
uniprot id: Q5R632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
messages: Membrane
messages: Probably binds two or three calcium ions.

9601:MS4A7
gene id: 9601:MS4A7
uniprot id: H2NDA8
names: Similarity
messages: Belongs to the MS4A family.

9601:NPBWR1
gene id: 9601:NPBWR1
uniprot id: H2PQA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GNB5
gene id: 9601:GNB5
uniprot id: Q5RDY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: Component of a complex composed of RGS9, GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By similarity). Interacts with RGS6 and RGS7 (By similarity).
messages: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
messages: Membrane

9601:RBFOX2
gene id: 9601:RBFOX2
uniprot id: A0A2J8UVT6
uniprot id: A0A2J8UVT9
uniprot id: A0A2J8UVU8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XPO4
gene id: 9601:XPO4
uniprot id: A0A6D2WML7
uniprot id: H2NJD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100441382
gene id: 9601:LOC100441382
uniprot id: H2NRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9601:PAH
gene id: 9601:PAH
uniprot id: Q5RDX0
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9601:CTCFL
gene id: 9601:CTCFL
uniprot id: A0A2J8TXH3
uniprot id: A0A2J8TXH4
uniprot id: A0A2J8TXI0
uniprot id: A0A2J8TXI9
uniprot id: A0A6D2XVM6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARHGAP26
gene id: 9601:ARHGAP26
uniprot id: A0A2J8VNW2
uniprot id: H2PGX3
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: focal adhesion

9601:PRDM4
gene id: 9601:PRDM4
uniprot id: Q5R5M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9601:CNOT3
gene id: 9601:CNOT3
uniprot id: H2P020
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9601:GMPPA
gene id: 9601:GMPPA
uniprot id: A0A6D2WA53
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9601:NME5
gene id: 9601:NME5
uniprot id: H2PGN4
names: Similarity
messages: Belongs to the NDK family.

9601:NTRK3
gene id: 9601:NTRK3
uniprot id: A0A2J8VWT6
uniprot id: A0A6D2WMA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9601:FOXF1
gene id: 9601:FOXF1
uniprot id: H2NRP8
names: Subcellular Location Annotation
messages: Nucleus

9601:CMAS
gene id: 9601:CMAS
uniprot id: A0A2J8XXL1
uniprot id: Q5R6R5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity).
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.
messages: Nucleus
messages: The BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RND3
gene id: 9601:RND3
uniprot id: Q5R9F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
messages: Binds ROCK1. Interacts with UBXD5 (By similarity).
messages: Cell membrane

9601:MEPCE
gene id: 9601:MEPCE
uniprot id: Q5R619
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9601:TUBG1
gene id: 9601:TUBG1
uniprot id: A0A2J8RF31
uniprot id: Q5RB24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9601:PCSK2
gene id: 9601:PCSK2
uniprot id: A0A2J8VD75
uniprot id: A0A2J8VD76
uniprot id: A0A2J8VD78
uniprot id: Q5REC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: secretory vesicle

9601:ABL2
gene id: 9601:ABL2
uniprot id: A0A2J8UC56
uniprot id: A0A2J8UC60
uniprot id: A0A2J8UC62
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RNF20
gene id: 9601:RNF20
uniprot id: H2PSX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9601:TRAK2
gene id: 9601:TRAK2
uniprot id: Q5R466
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9601:PRUNE2
gene id: 9601:PRUNE2
uniprot id: Q5R4Q8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.

9601:RPS17
gene id: 9601:RPS17
uniprot id: H2NIT0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9601:MAATS1
gene id: 9601:MAATS1
uniprot id: H2P9M2
names: Similarity
messages: Belongs to the CFAP91 family.

9601:NRXN3
gene id: 9601:NRXN3
uniprot id: Q5RA99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:COX4I1
gene id: 9601:COX4I1
uniprot id: H2NRP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9601:TIMELESS
gene id: 9601:TIMELESS
uniprot id: H2NHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9601:TPM1
gene id: 9601:TPM1
uniprot id: Q5RBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9601:MSRB3
gene id: 9601:MSRB3
uniprot id: A0A2J8W0T0
uniprot id: Q5R930
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
messages: Endoplasmic reticulum
messages: Has a transit peptide.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
messages: Mitochondrion
messages: Monomer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GCNT4
gene id: 9601:GCNT4
uniprot id: H2PFV6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9601:RCAN3
gene id: 9601:RCAN3
uniprot id: A0A6D2WS35
names: Similarity
messages: Belongs to the RCAN family.

9601:SMIM1
gene id: 9601:SMIM1
uniprot id: A0A2J8URN8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VDR
gene id: 9601:VDR
uniprot id: Q5R8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9601:YWHAG
gene id: 9601:YWHAG
uniprot id: A0A2J8XU01
uniprot id: Q5RC20
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2 and SAMSN1. Interacts with PKA-phosphorylated AANAT and SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with MEFV (By similarity). Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (By similarity). Interacts with TH (phosphorylated form); one YWHAG dimer bounds to one TH tetramer, this interaction may influence the phosphorylation and dephosphorylation of TH (By similarity).
messages: Phosphorylated by various PKC isozymes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP6V1A
gene id: 9601:ATP6V1A
uniprot id: A0A2J8W2K4
uniprot id: Q5R5H2
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity).
messages: Cytoplasm
messages: Lysosome
messages: Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (By similarity). Interacts with WFS1 (By similarity). Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex (By similarity).
messages: clathrin-coated vesicle membrane
messages: cytosol
messages: secretory vesicle

9601:KCNB2
gene id: 9601:KCNB2
uniprot id: H2PQJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

9601:C8H8orf46
gene id: 9601:C8H8orf46
uniprot id: Q5R5R7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Nucleus
messages: Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.

9601:LAGE3
gene id: 9601:LAGE3
uniprot id: A0A663D8A1
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9601:PLSCR4
gene id: 9601:PLSCR4
uniprot id: Q5RCV5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9601:ATP6V0A2
gene id: 9601:ATP6V0A2
uniprot id: H2NJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9601:CPT1B
gene id: 9601:CPT1B
uniprot id: A0A2J8XTK2
uniprot id: A0A6D2XKP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:IZUMO4
gene id: 9601:IZUMO4
uniprot id: A0A2J8R3S6
uniprot id: A0A2J8R3U5
names: Caution
names: Similarity
messages: Belongs to the Izumo family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCNL1
gene id: 9601:CCNL1
uniprot id: H2PBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9601:PHTF1
gene id: 9601:PHTF1
uniprot id: A0A6D2X779
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100435934
gene id: 9601:LOC100435934
uniprot id: H2N3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9601:ACTR6
gene id: 9601:ACTR6
uniprot id: H2NID3
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9601:LOC100439850
gene id: 9601:LOC100439850
uniprot id: A0A6D2W0V3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TSPYL6
gene id: 9601:TSPYL6
uniprot id: H2P678
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9601:SERPINC1
gene id: 9601:SERPINC1
uniprot id: A0A2J8UBV4
uniprot id: Q5R5A3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular space

9601:PLA2G2D
gene id: 9601:PLA2G2D
uniprot id: H2N8R9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9601:LOC100436823
gene id: 9601:LOC100436823
uniprot id: A0A6D2W1Y9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAS2R60
gene id: 9601:TAS2R60
uniprot id: H2PNW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:ZNF81
gene id: 9601:ZNF81
uniprot id: A0A2J8WIF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:XIAP
gene id: 9601:XIAP
uniprot id: A0A2J8WWM1
names: Similarity
messages: Belongs to the IAP family.

9601:ASTN2
gene id: 9601:ASTN2
uniprot id: A0A2J8WRK5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C14H14orf119
gene id: 9601:C14H14orf119
uniprot id: A0A6D2W1H6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLEKHA8
gene id: 9601:PLEKHA8
uniprot id: A0A2J8UP33
uniprot id: A0A6D2W1T8
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9601:GSTA1
gene id: 9601:GSTA1
uniprot id: H2PJD2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9601:DHFR2
gene id: 9601:DHFR2
uniprot id: A0A6D2XGV9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9601:CCL11
gene id: 9601:CCL11
uniprot id: H2NTB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:ZFAND2B
gene id: 9601:ZFAND2B
uniprot id: A0A2J8TUI2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AP3B1
gene id: 9601:AP3B1
uniprot id: H2PFY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9601:CCNT1
gene id: 9601:CCNT1
uniprot id: H2NH51
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9601:TAP1
gene id: 9601:TAP1
uniprot id: H2PL26
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9601:ADPRHL2
gene id: 9601:ADPRHL2
uniprot id: H2N803
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9601:PCK1
gene id: 9601:PCK1
uniprot id: Q5R5J1
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Lysine acetylation by p300/EP300 is increased on high glucose conditions. Lysine acetylation promotes ubiquitination by UBR5. Acetylation is enhanced in the presence of BAG6. Deacetylated by SIRT2. Deacetylation of Lys-91 is carried out by SIRT1 and depends on PCK1 phosphorylation levels.
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (By similarity). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis. The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor. The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity).
messages: Endoplasmic reticulum
messages: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.
messages: Monomer.
messages: Phosphoenolpyruvate carboxykinase activity is regulated by acetylation and glucose levels (By similarity). The anaplerotic conversion of phosphoenolpyruvate to oxaloacetate is improved by PCK1 acetylation on Lys-91 (K91ac), Lys-473 (K473ac) and Lys-521 (K521ac) (By similarity). High glucose concentrations favor PCK1 anaplerotic activity by triggering acetylation on Lys-91 (K91ac). At low glucose levels, SIRT1-mediated deacetylation of Lys-91 promotes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate. Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and converts the enzyme into an atypical protein kinase using GTP as donor (By similarity).
messages: Phosphorylated in a GSK3B-mediated pathway; phosphorylation affects the efficiency of SIRT1-mediated deacetylation, and regulates PCK1 ubiquitination and degradation. Phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes the protein kinase activity: phosphorylated PCK1 translocates to the endoplasmic reticulum, where it phosphorylates INSIG1 and INSIG2.
messages: Ubiquitination by UBR5 leads to proteasomal degradation.
messages: cytosol

9601:SIAE
gene id: 9601:SIAE
uniprot id: Q5RFU0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
messages: Lysosome

9601:STX17
gene id: 9601:STX17
uniprot id: A0A6D2X6Y4
names: Similarity
messages: Belongs to the syntaxin family.

9601:TRMO
gene id: 9601:TRMO
uniprot id: H2PSU8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9601:THY1
gene id: 9601:THY1
uniprot id: Q5R508
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9601:AVP
gene id: 9601:AVP
uniprot id: H2P1D4
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9601:SERINC4
gene id: 9601:SERINC4
uniprot id: H2NN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9601:PPP1CB
gene id: 9601:PPP1CB
uniprot id: A0A2J8VNA3
uniprot id: Q5R740
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3D (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824'. Interacts with FOXP3. Interacts with RRP1B. Interacts with SERPINE1. Interacts with LZTR1 (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus
messages: nucleoplasm

9601:LOC100453113
gene id: 9601:LOC100453113
uniprot id: H2NDE3
names: Subcellular Location Annotation
messages: Membrane

9601:CUL4A
gene id: 9601:CUL4A
uniprot id: H2NKD8
names: Similarity
messages: Belongs to the cullin family.

9601:MAF1
gene id: 9601:MAF1
uniprot id: A0A2J8RHL4
uniprot id: A0A6D2VX91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPSF7
gene id: 9601:CPSF7
uniprot id: A0A2J8SMS7
uniprot id: A0A6D2WS39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EIF3I
gene id: 9601:EIF3I
uniprot id: Q5R7R2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9601:IL36RN
gene id: 9601:IL36RN
uniprot id: A0A6D2WD24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9601:EMC8
gene id: 9601:EMC8
uniprot id: H2NRP3
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9601:FOXJ1
gene id: 9601:FOXJ1
uniprot id: H2NUS8
names: Subcellular Location Annotation
messages: Nucleus

9601:PITPNB
gene id: 9601:PITPNB
uniprot id: Q5R6F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
messages: Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Golgi apparatus membrane

9601:KEF63 p10
gene id: 9601:KEF63_p10
uniprot id: C5H6I8
uniprot id: P92693
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9601:LOC100461022
gene id: 9601:LOC100461022
uniprot id: A0A663DID6
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9601:LHFPL4
gene id: 9601:LHFPL4
uniprot id: A0A663DDQ3
names: Subcellular Location Annotation
messages: Membrane

9601:FZD5
gene id: 9601:FZD5
uniprot id: H2P8F5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:NR1I2
gene id: 9601:NR1I2
uniprot id: A0A2J8W282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9601:EFCAB3
gene id: 9601:EFCAB3
uniprot id: A0A663D8Z1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCND3
gene id: 9601:CCND3
uniprot id: H2PJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9601:PRKCZ
gene id: 9601:PRKCZ
uniprot id: A0A8I3B112
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:PTPRK
gene id: 9601:PTPRK
uniprot id: Q5RDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9601:LPCAT1
gene id: 9601:LPCAT1
uniprot id: A0A6D2Y5G0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9601:CUEDC2
gene id: 9601:CUEDC2
uniprot id: H2NBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9601:NUDT4
gene id: 9601:NUDT4
uniprot id: A0A2J8XN76
uniprot id: A0A2J8XN81
uniprot id: Q5RAF0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.
messages: Binds 3 Mg(2+) or Mn(2+) ions per subunit.
messages: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (By similarity). Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (By similarity). Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM138
gene id: 9601:TMEM138
uniprot id: H2ND83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9601:CMTM6
gene id: 9601:CMTM6
uniprot id: Q5RFC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chemokine-like factor family.
messages: Cell membrane
messages: Early endosome membrane
messages: Interacts with PD-L1/CD274 (via transmembrane domain); the interaction is direct. Interacts with CMTM4. Interacts with CD58, ARG1, ENO1 and TMPO.
messages: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
messages: Recycling endosome membrane

9601:ADHFE1
gene id: 9601:ADHFE1
uniprot id: Q5RF11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
messages: Mitochondrion

9601:OPRK1
gene id: 9601:OPRK1
uniprot id: A0A2J8UN27
uniprot id: A0A663D6E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100437347
gene id: 9601:LOC100437347
uniprot id: A0A6D2XEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9601:GABRA2
gene id: 9601:GABRA2
uniprot id: Q5RCC5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Glycosylated.
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with UBQLN1 (By similarity). Interacts with KIF21B (By similarity). Interacts with LHFPL4 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).
messages: Postsynaptic cell membrane
messages: The extracellular domain contributes to synaptic contact formation.
messages: dendrite

9601:TMEM263
gene id: 9601:TMEM263
uniprot id: A0A2J8XLV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPIL3
gene id: 9601:PPIL3
uniprot id: H2P891
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:TYR
gene id: 9601:TYR
uniprot id: H2NEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9601:TGIF2
gene id: 9601:TGIF2
uniprot id: A0A6D2WZB3
names: Subcellular Location Annotation
messages: Nucleus

9601:LGR4
gene id: 9601:LGR4
uniprot id: H2NDU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:PPP1R36
gene id: 9601:PPP1R36
uniprot id: A0A663DHR6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PFKP
gene id: 9601:PFKP
uniprot id: Q5R636
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: GlcNAcylation decreases enzyme activity.
messages: Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts with ATG4B; promoting phosphorylation of ATG4B.
messages: Phosphorylation at Ser-386 promotes interaction with ATG4B.

9601:KIF13B
gene id: 9601:KIF13B
uniprot id: Q5R7M5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9601:ESYT1
gene id: 9601:ESYT1
uniprot id: Q5RAG2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.
messages: Belongs to the extended synaptotagmin family.
messages: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity).
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with ESYT2 and ESYT3. Interacts (phosphorylated form) with SLC2A4 (By similarity).
messages: Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.
messages: The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium. The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for translocation to the cell membrane in response to increased cytosolic calcium levels (By similarity).
messages: The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).

9601:RDX
gene id: 9601:RDX
uniprot id: A0A2J8X246
uniprot id: A0A2J8X255
uniprot id: A0A2J8X257
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:LOC100456998
gene id: 9601:LOC100456998
uniprot id: H2NAP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9601:MUCL1
gene id: 9601:MUCL1
uniprot id: A0A2J8UIB7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BLCAP
gene id: 9601:BLCAP
uniprot id: A0A2J8VJQ7
uniprot id: Q5R692
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PDIA2
gene id: 9601:PDIA2
uniprot id: Q5RCH2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity).
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Glycosylated.
messages: Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).
messages: The disulfide-linked homodimer exhibits an enhanced chaperone activity.

9601:KCNV2
gene id: 9601:KCNV2
uniprot id: H2PS93
names: Subcellular Location Annotation
messages: Membrane

9601:WNT5B
gene id: 9601:WNT5B
uniprot id: A0A2J8S3M2
uniprot id: Q5NVK2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Interacts with PORCN.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:GBX2
gene id: 9601:GBX2
uniprot id: A0A2J8TPQ2
uniprot id: A0A2J8TPT2
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100439576
gene id: 9601:LOC100439576
uniprot id: A0A2J8T1Q0
names: Function
names: Similarity
messages: Belongs to the VCX/VCY family.
messages: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

9601:STK25
gene id: 9601:STK25
uniprot id: A0A2J8RPP4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BIRC7
gene id: 9601:BIRC7
uniprot id: A0A6D2X4R0
uniprot id: H2P2K9
names: Caution
names: Similarity
messages: Belongs to the IAP family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100434214
gene id: 9601:LOC100434214
uniprot id: H2N5S3
names: Similarity
messages: Belongs to the LCE family.

9601:SIRT4
gene id: 9601:SIRT4
uniprot id: H2NIV1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9601:NEUROD2
gene id: 9601:NEUROD2
uniprot id: H2NUA3
names: Subcellular Location Annotation
messages: Nucleus

9601:SLC22A7
gene id: 9601:SLC22A7
uniprot id: A0A2J8Y4I6
uniprot id: Q5R540
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Mediates sodium-independent multispecific organic anion transport.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NKX3-2
gene id: 9601:NKX3-2
uniprot id: H2PCX8
names: Subcellular Location Annotation
messages: Nucleus

9601:STMN2
gene id: 9601:STMN2
uniprot id: A0A2J8V9Y8
uniprot id: A0A663D6R7
uniprot id: H2PQM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: lamellipodium

9601:FAHD1
gene id: 9601:FAHD1
uniprot id: A0A2J8R9A9
uniprot id: A0A2J8R9B3
uniprot id: Q5RDW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAH family.
messages: Homodimer.
messages: Mitochondrion
messages: Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:RAB5B
gene id: 9601:RAB5B
uniprot id: A0A2J8UHV6
uniprot id: Q5RBG1
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-84 disrupts this interaction (By similarity).
messages: Cell membrane
messages: Early endosome membrane
messages: Melanosome
messages: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GALK1
gene id: 9601:GALK1
uniprot id: A0A6D2WZP9
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9601:UBAC2
gene id: 9601:UBAC2
uniprot id: H2NK75
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100457673
gene id: 9601:LOC100457673
uniprot id: A0A2J8WSM4
uniprot id: H2PBP2
names: Caution
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NAPB
gene id: 9601:NAPB
uniprot id: A0A6D2X801
uniprot id: Q5R4D1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM199X
gene id: 9601:FAM199X
uniprot id: A0A6D2X3Z3
names: Similarity
messages: Belongs to the FAM199 family.

9601:LIPT2
gene id: 9601:LIPT2
uniprot id: H2NEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9601:PJVK
gene id: 9601:PJVK
uniprot id: A0A2J8VRG9
uniprot id: A0A6D2W674
names: Caution
names: Similarity
messages: Belongs to the gasdermin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC31A1
gene id: 9601:SLC31A1
uniprot id: Q5RAS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Cell membrane
messages: High-affinity, saturable copper transporter involved in dietary copper uptake.
messages: Homotrimer.

9601:CRYZ
gene id: 9601:CRYZ
uniprot id: A0A6D2XP51
uniprot id: Q5R4S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Cytoplasm
messages: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).
messages: Homotetramer.

9601:FABP5
gene id: 9601:FABP5
uniprot id: H2PQN1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9601:ARL6IP6
gene id: 9601:ARL6IP6
uniprot id: A0A6D2YCC4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGF9
gene id: 9601:FGF9
uniprot id: A0A663D593
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9601:CALCA
gene id: 9601:CALCA
uniprot id: A0A2J8UQ72
uniprot id: A0A2J8UQ73
names: Similarity
messages: Belongs to the calcitonin family.

9601:PARD6B
gene id: 9601:PARD6B
uniprot id: A0A663DCY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9601:FOXJ3
gene id: 9601:FOXJ3
uniprot id: A0A2J8Y5X0
uniprot id: A0A6D2XAC5
names: Subcellular Location Annotation
messages: Nucleus

9601:PPWD1
gene id: 9601:PPWD1
uniprot id: Q5NVL7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
messages: Identified in the spliceosome C complex.
messages: Inhibited by cyclosporin A (CsA).
messages: Nucleus
messages: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing.

9601:TCN2
gene id: 9601:TCN2
uniprot id: Q5REL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Interacts with CD320 (via LDL-receptor class A domains).
messages: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
messages: Secreted

9601:SIRPB2
gene id: 9601:SIRPB2
uniprot id: A0A2J8VI70
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GTF2H1
gene id: 9601:GTF2H1
uniprot id: A0A6D2XPB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9601:C17H17orf50
gene id: 9601:C17H17orf50
uniprot id: A0A6D2WHV4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KRT83
gene id: 9601:KRT83
uniprot id: H2NHD1
names: Similarity
messages: Belongs to the intermediate filament family.

9601:ACP1
gene id: 9601:ACP1
uniprot id: A0A2J8SHE4
uniprot id: Q5REM7
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm
messages: Inhibited by sulfhydryl reagents.
messages: Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. Interacts with the SH3 domain of SPTAN1.
messages: Phosphorylated by LCK. Phosphorylation at Tyr-132 increases its phosphatase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NARF
gene id: 9601:NARF
uniprot id: A0A2J8XZM9
names: Caution
names: Similarity
messages: Belongs to the NARF family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MSL3
gene id: 9601:MSL3
uniprot id: A0A2J8W4M7
uniprot id: Q5R6Y9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MSL histone acetyltransferase complex at least composed of the KAT8/MOF, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1 and KAT8/MOF.
messages: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KIF5A
gene id: 9601:KIF5A
uniprot id: Q5R9K7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
messages: Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
messages: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
messages: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1. Interacts with FMR1 (via C-terminus); this interaction is increased in a mGluR-dependent manner. Interacts with BORCS5. Interacts with ZFYVE27. Interacts with VAPA, VAPB, SURF4, RAB11A (GDP-bound form), RAB11B (GDP-bound form) and RTN3 in a ZFYVE27-dependent manner. Interacts with BICD2. Interacts with DTNB (By similarity).
messages: Perikaryon
messages: cytoskeleton
messages: perinuclear region

9601:OAZ1
gene id: 9601:OAZ1
uniprot id: A0A2J8R3T4
names: Caution
names: Similarity
messages: Belongs to the ODC antizyme family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNRPD2
gene id: 9601:SNRPD2
uniprot id: A0A2J8U6P6
uniprot id: A0A6D2X0B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:LOC100442854
gene id: 9601:LOC100442854
uniprot id: H2NU41
names: Similarity
messages: Belongs to the intermediate filament family.

9601:HYI
gene id: 9601:HYI
uniprot id: A0A6D2VST5
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9601:XCR1
gene id: 9601:XCR1
uniprot id: H2PAY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:SNURF
gene id: 9601:SNURF
uniprot id: Q5R6I0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
messages: Interacts with TDRD3.
messages: May be involved in tissue-specific alternative RNA processing events.
messages: Nucleus

9601:CD36
gene id: 9601:CD36
uniprot id: A0A2J8VLF8
uniprot id: A0A2J8VLI9
uniprot id: A0A6D2Y9Y9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NECAP1
gene id: 9601:NECAP1
uniprot id: Q5R630
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NECAP family.
messages: Cell membrane
messages: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
messages: Involved in endocytosis.
messages: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2 (By similarity).
messages: clathrin-coated vesicle membrane

9601:LOC100453544
gene id: 9601:LOC100453544
uniprot id: H2NZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9601:BABAM2
gene id: 9601:BABAM2
uniprot id: A0A8I5TE26
uniprot id: Q5REX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9601:OXTR
gene id: 9601:OXTR
uniprot id: H2PA62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9601:ANXA1
gene id: 9601:ANXA1
uniprot id: A0A2J8SUA4
uniprot id: Q5REL2
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.
messages: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
messages: Secreted
messages: Sumoylated.
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9601:JADE2
gene id: 9601:JADE2
uniprot id: A0A2J8VQA8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BLK
gene id: 9601:BLK
uniprot id: H2PPJ4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9601:PTDSS1
gene id: 9601:PTDSS1
uniprot id: A0A2J8UF01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:FBXO39
gene id: 9601:FBXO39
uniprot id: A0A663DEJ0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STMN3
gene id: 9601:STMN3
uniprot id: A0A2J8RAY4
uniprot id: Q5R8C6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
messages: Golgi apparatus
messages: Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).
messages: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: axon
messages: cytosol
messages: growth cone

9601:ANKH
gene id: 9601:ANKH
uniprot id: H2PF77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9601:LOC100446516
gene id: 9601:LOC100446516
uniprot id: A0A6D2WDH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GATC
gene id: 9601:GATC
uniprot id: H2NIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9601:C11H11orf87
gene id: 9601:C11H11orf87
uniprot id: A0A2J8X278
uniprot id: Q5RCL0
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IGFL2
gene id: 9601:IGFL2
uniprot id: K7ETJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9601:C12H12orf29
gene id: 9601:C12H12orf29
uniprot id: A0A2J8SW54
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SFPQ
gene id: 9601:SFPQ
uniprot id: A0A8I5YQF5
uniprot id: H2N816
names: Subcellular Location Annotation
messages: Nucleus speckle

9601:SLC12A6
gene id: 9601:SLC12A6
uniprot id: Q5RAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9601:FARSA
gene id: 9601:FARSA
uniprot id: A0A2J8RY25
uniprot id: Q5RFA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Cytoplasm
messages: Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KLHL7
gene id: 9601:KLHL7
uniprot id: A0A2J8VE41
uniprot id: A0A663DE78
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPL12
gene id: 9601:MRPL12
uniprot id: H2NV24
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9601:TRIM54
gene id: 9601:TRIM54
uniprot id: A0A2J8VN07
uniprot id: Q5REJ9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55. Interacts with tubulin (By similarity).
messages: May bind and stabilize microtubules during myotubes formation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Z line
messages: cytoskeleton

9601:PAFAH1B2
gene id: 9601:PAFAH1B2
uniprot id: A0A2J8X1B8
uniprot id: Q5R4G2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity).
messages: Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
messages: Beta subunit (PAFAH1B1) stimulates the acetylhydrolase activity of the alpha2/alpha2 catalytic homodimer.
messages: Cytoplasm
messages: Forms a catalytic dimer which is either homodimer (alpha2/alpha2 homodimer) or heterodimer with PAFAH1B3 (alpha2/alpha1 heterodimer). Component of the cytosolic (PAF-AH (I)) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts (homodimer form) with PAFAH1B1 (homodimer form); PAFAH1B2 competes with NDEL1 for PAFAH1B1 binding (By similarity). Interacts with VLDLR; this interaction may modulate the Reelin pathway (By similarity).
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CETN3
gene id: 9601:CETN3
uniprot id: A0A2J8UX61
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHRM5
gene id: 9601:CHRM5
uniprot id: A0A6D2WAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9601:ARL6
gene id: 9601:ARL6
uniprot id: Q5R4G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Interacts with SEC61B, ARL6IP1, ARL6IP2, ARL6IP3, ARL6IP4 ARL6IP5 and ARL6IP6. Interacts (GTP-bound form) with the BBSome a complex that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (GTP-free form) with IFT27.
messages: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity).
messages: cilium axoneme
messages: cilium basal body
messages: cilium membrane

9601:TEKT2
gene id: 9601:TEKT2
uniprot id: H2N804
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9601:IL2RA
gene id: 9601:IL2RA
uniprot id: A0A2J8VK42
uniprot id: H2N9P4
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MCPH1
gene id: 9601:MCPH1
uniprot id: H2PPE4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9601:ZNF212
gene id: 9601:ZNF212
uniprot id: A0A6D2Y9J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:RHBDL2
gene id: 9601:RHBDL2
uniprot id: A0A6D2X9Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9601:PSME2
gene id: 9601:PSME2
uniprot id: A0A2J8TRG3
uniprot id: A0A6D2WFW0
names: Caution
names: Similarity
messages: Belongs to the PA28 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GNG11
gene id: 9601:GNG11
uniprot id: H2PMW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9601:ERAP1
gene id: 9601:ERAP1
uniprot id: Q5R6K9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9601:ATP5MC2
gene id: 9601:ATP5MC2
uniprot id: Q5RAP9
names: Disease Annotation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with DNAJC30; interaction is direct.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane
messages: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.
messages: This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).
messages: Trimethylated by ATPSCKMT at Lys-109. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.

9601:PPT2
gene id: 9601:PPT2
uniprot id: H2PIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9601:ACAD9
gene id: 9601:ACAD9
uniprot id: H2P9E5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9601:ILF2
gene id: 9601:ILF2
uniprot id: A0A2J8VFN5
uniprot id: A0A2J8VFP5
uniprot id: Q5RFJ1
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Plays also a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71.
messages: Cytoplasm
messages: Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1. Interacts with CRBN; this interaction promotes ubiquitination and subsequent degradation of ILF2.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated at Lys-45 by CRBN with polyubiquitin chains by the CUL4-RING E3 ligase (CRL4-CRBN) and then degraded by the proteasome.
messages: nucleolus

9601:LOC100448112
gene id: 9601:LOC100448112
uniprot id: A0A8I5YKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9601:MEOX2
gene id: 9601:MEOX2
uniprot id: H2PMS4
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100449542
gene id: 9601:LOC100449542
uniprot id: A0A2J8XWP9
names: Subcellular Location Annotation
messages: Nucleus

9601:RARB
gene id: 9601:RARB
uniprot id: H2PBB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9601:TTLL9
gene id: 9601:TTLL9
uniprot id: A0A2J8VIL6
uniprot id: A0A6D2W8T7
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

9601:CKMT2
gene id: 9601:CKMT2
uniprot id: A0A2J8UWT9
uniprot id: Q5R7B5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Exists as an octamer composed of four CKMT2 homodimers.
messages: Mitochondrial creatine kinase binds cardiolipin.
messages: Mitochondrion inner membrane
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CD3E
gene id: 9601:CD3E
uniprot id: H2NFG6
names: Subcellular Location Annotation
messages: Membrane

9601:SLC35E1
gene id: 9601:SLC35E1
uniprot id: H2NXY6
names: Subcellular Location Annotation
messages: Membrane

9601:AKAP3
gene id: 9601:AKAP3
uniprot id: A0A6D2X5M8
names: Similarity
messages: Belongs to the AKAP110 family.

9601:YPEL2
gene id: 9601:YPEL2
uniprot id: A0A2J8W7M8
uniprot id: Q5RDN9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the yippee family.
messages: May interact with FAM168B.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:AMPD1
gene id: 9601:AMPD1
uniprot id: A0A2J8ULT6
uniprot id: H2N6A3
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9601:AASDH
gene id: 9601:AASDH
uniprot id: A0A2J8S2F1
uniprot id: H2PDD0
names: Caution
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C8G
gene id: 9601:C8G
uniprot id: H2PU08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9601:CERS2
gene id: 9601:CERS2
uniprot id: A0A6D2WGD1
uniprot id: Q5RDU6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9601:MED15
gene id: 9601:MED15
uniprot id: Q5R7T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9601:ITGA2B
gene id: 9601:ITGA2B
uniprot id: H2NTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9601:MAEA
gene id: 9601:MAEA
uniprot id: A0A2J8SS63
uniprot id: Q5R532
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).
messages: Cell membrane
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
messages: Cytoplasm
messages: Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with F-actin.
messages: Nucleus matrix
messages: The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: nucleoplasm

9601:CCL14
gene id: 9601:CCL14
uniprot id: A0A2J8RCK5
uniprot id: A0A2J8RCK6
uniprot id: A0A2J8RCM5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CAP1
gene id: 9601:CAP1
uniprot id: A0A2J8Y680
uniprot id: A0A6D2Y4K1
uniprot id: Q5R8B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers (By similarity).
messages: Homodimer. Binds actin monomers.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AFP
gene id: 9601:AFP
uniprot id: A0A6D2XJ44
uniprot id: H2PDK1
names: Subcellular Location Annotation
messages: Secreted

9601:DUSP3
gene id: 9601:DUSP3
uniprot id: A0A2J8UY54
uniprot id: Q5RD73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
messages: Interacts with VRK3, which seems to activate it's phosphatase activity.
messages: Nucleus
messages: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF766
gene id: 9601:ZNF766
uniprot id: H2NZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:TAC1
gene id: 9601:TAC1
uniprot id: H2PMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9601:FAM69A
gene id: 9601:FAM69A
uniprot id: A0A2J8VCX1
uniprot id: Q5R634
names: Caution
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RRAD
gene id: 9601:RRAD
uniprot id: H2NR52
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9601:POGK
gene id: 9601:POGK
uniprot id: Q5R5W7
names: Subcellular Location Annotation
messages: Nucleus

9601:SUPT16H
gene id: 9601:SUPT16H
uniprot id: H2NKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9601:TMEM115
gene id: 9601:TMEM115
uniprot id: H2PAN3
names: Subcellular Location Annotation
messages: Membrane

9601:MMP3
gene id: 9601:MMP3
uniprot id: H2NF35
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:SLC2A2
gene id: 9601:SLC2A2
uniprot id: H2PBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9601:DCN
gene id: 9601:DCN
uniprot id: A0A6D2VX41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9601:AFF2
gene id: 9601:AFF2
uniprot id: A0A2J8XTS3
uniprot id: A0A2J8XTV0
uniprot id: A0A2J8XTY7
uniprot id: H2PX09
names: Caution
names: Similarity
messages: Belongs to the AF4 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAS2R14
gene id: 9601:TAS2R14
uniprot id: H2NGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:SLC7A9
gene id: 9601:SLC7A9
uniprot id: A0A6D2WSB5
names: Subcellular Location Annotation
messages: Membrane

9601:GDF5
gene id: 9601:GDF5
uniprot id: A0A6D2WR54
names: Similarity
messages: Belongs to the TGF-beta family.

9601:CCNJ
gene id: 9601:CCNJ
uniprot id: A0A2J8Y529
names: Similarity
messages: Belongs to the cyclin family.

9601:LOC100462105
gene id: 9601:LOC100462105
uniprot id: A0A6D2W446
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9601:MARCKSL1
gene id: 9601:MARCKSL1
uniprot id: H2N851
names: Similarity
messages: Belongs to the MARCKS family.

9601:LOC100447607
gene id: 9601:LOC100447607
uniprot id: A0A663DG97
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9601:LOC100450877
gene id: 9601:LOC100450877
uniprot id: H2NEB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:DPH5
gene id: 9601:DPH5
uniprot id: A0A6D2W124
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9601:RPL3
gene id: 9601:RPL3
uniprot id: H2P4F6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9601:CAMK2N1
gene id: 9601:CAMK2N1
uniprot id: A0A6D2W7G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9601:FN3KRP
gene id: 9601:FN3KRP
uniprot id: Q5R7D2
names: Similarity
messages: Belongs to the fructosamine kinase family.

9601:CACNB4
gene id: 9601:CACNB4
uniprot id: A0A2J8V7C6
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9601:FOXM1
gene id: 9601:FOXM1
uniprot id: H2NG48
names: Subcellular Location Annotation
messages: Nucleus

9601:DIMT1
gene id: 9601:DIMT1
uniprot id: H2PFN1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9601:STX19
gene id: 9601:STX19
uniprot id: Q5RAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with EGFR.
messages: Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).

9601:CCDC43
gene id: 9601:CCDC43
uniprot id: A0A2J8UYL9
uniprot id: A0A2J8UYM0
names: Caution
names: Similarity
messages: Belongs to the CCDC43 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BRMS1
gene id: 9601:BRMS1
uniprot id: H2NG00
names: Subcellular Location Annotation
messages: Nucleus

9601:HCRT
gene id: 9601:HCRT
uniprot id: H2NU12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9601:RNF114
gene id: 9601:RNF114
uniprot id: H2P296
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9601:CDK16
gene id: 9601:CDK16
uniprot id: A0A6D2WTU0
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CD8B
gene id: 9601:CD8B
uniprot id: A0A2J8RNU5
uniprot id: A0A8I5UMY9
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TNC
gene id: 9601:TNC
uniprot id: H2PT66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9601:LPGAT1
gene id: 9601:LPGAT1
uniprot id: A0A2J8V6D2
uniprot id: A0A6D2W4L8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MINPP1
gene id: 9601:MINPP1
uniprot id: Q5R890
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). Through the regulation of intracellular inositol polyphosphates, may control intracellular cation homeostasis, including that of calcium and iron, hence affecting free cation availability required for neural cell signaling (By similarity).
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
messages: Endoplasmic reticulum lumen

9601:LIPG
gene id: 9601:LIPG
uniprot id: A0A2J8UEG8
uniprot id: H2NWC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:PCYOX1L
gene id: 9601:PCYOX1L
uniprot id: H2PH15
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9601:ACTG1
gene id: 9601:ACTG1
uniprot id: A0A6D2XWB9
names: Similarity
messages: Belongs to the actin family.

9601:FARSB
gene id: 9601:FARSB
uniprot id: H2P8R2
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9601:SUGT1
gene id: 9601:SUGT1
uniprot id: H2NJZ5
names: Similarity
messages: Belongs to the SGT1 family.

9601:FAM149B1
gene id: 9601:FAM149B1
uniprot id: H2NAK4
names: Similarity
messages: Belongs to the FAM149 family.

9601:IGF1R
gene id: 9601:IGF1R
uniprot id: H2NP98
uniprot id: Q5RCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9601:PTPN2
gene id: 9601:PTPN2
uniprot id: A0A2J8RSH4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9601:ZIC4
gene id: 9601:ZIC4
uniprot id: A0A2J8WSN5
uniprot id: A0A2J8WSP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9601:EIF3J
gene id: 9601:EIF3J
uniprot id: A0A2J8S4C4
uniprot id: Q5R8D1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ABCB11
gene id: 9601:ABCB11
uniprot id: H2P7R1
names: Subcellular Location Annotation
messages: Endosome

9601:MEAF6
gene id: 9601:MEAF6
uniprot id: A0A2J8Y6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9601:BDKRB1
gene id: 9601:BDKRB1
uniprot id: H2NM71
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9601:RNF185
gene id: 9601:RNF185
uniprot id: A0A2J8UVD2
uniprot id: Q5RFK9
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
messages: Endoplasmic reticulum membrane
messages: Interacts with ATG5 and BNIP1.
messages: Mitochondrion outer membrane
messages: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTPRZ1
gene id: 9601:PTPRZ1
uniprot id: H2PNB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9601:UCK1
gene id: 9601:UCK1
uniprot id: A0A2J8UJA3
uniprot id: H2PTR2
uniprot id: Q5R7S1
names: Similarity
messages: Belongs to the uridine kinase family.

9601:LOC100439140
gene id: 9601:LOC100439140
uniprot id: A0A8I5T0Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:THOP1
gene id: 9601:THOP1
uniprot id: H2NWY2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9601:PTGFR
gene id: 9601:PTGFR
uniprot id: A0A2J8WQB4
uniprot id: A0A2J8WQC7
uniprot id: A0A6D2W6B7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100457385
gene id: 9601:LOC100457385
uniprot id: A0A6D2XGS0
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DIABLO
gene id: 9601:DIABLO
uniprot id: A0A2J8XJJ0
uniprot id: Q5RBH2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). Interacts with BEX3 (By similarity). Interacts with BIRC2/c-IAP1 (via BIR3 domain) (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with BIRC7/livin (By similarity). Interacts with XIAP/BIRC4 (via BIR3 domain) (By similarity). Interacts with the monomeric and dimeric form of BIRC5/survivin (By similarity). Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (By similarity).
messages: Mitochondrion
messages: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).
messages: The mature N-terminus mediates interaction with XIAP/BIRC4.
messages: Ubiquitinated by BIRC7/livin.

9601:BPIFA3
gene id: 9601:BPIFA3
uniprot id: A0A663DFW8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LGALS3
gene id: 9601:LGALS3
uniprot id: H2NLB0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9601:DENR
gene id: 9601:DENR
uniprot id: Q5RFP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DENR family.
messages: Interacts with MCTS1.
messages: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).

9601:THAP4
gene id: 9601:THAP4
uniprot id: A0A2J8RPT2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OLFM3
gene id: 9601:OLFM3
uniprot id: A0A2J8VCI2
uniprot id: H2N6L8
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9601:CGA
gene id: 9601:CGA
uniprot id: A0A2J8VRJ3
uniprot id: H2PJR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

9601:ADCY4
gene id: 9601:ADCY4
uniprot id: H2NKW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9601:KPNB1
gene id: 9601:KPNB1
uniprot id: A0A6D2X2R2
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100431880
gene id: 9601:LOC100431880
uniprot id: H2P0X9
names: Similarity
messages: Belongs to the PRAME family.

9601:NT5C2
gene id: 9601:NT5C2
uniprot id: A0A2J8XYN2
uniprot id: A0A8I5U7Z5
uniprot id: Q5RA22
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4-bis(5'-adenosyl) tetraphosphate. Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding. Inhibited by inorganic phosphate.
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.
messages: Homotetramer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:CTTNBP2NL
gene id: 9601:CTTNBP2NL
uniprot id: A0A2J8UM39
uniprot id: Q5RDH2
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May form homomers (By similarity). May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2. Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity).
messages: Regulates lamellipodial actin dynamics in a CTTN-dependent manner.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: lamellipodium
messages: stress fiber

9601:GSS
gene id: 9601:GSS
uniprot id: A0A663DG57
uniprot id: H2P1Q7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NIPAL2
gene id: 9601:NIPAL2
uniprot id: H2PQW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9601:HEXA
gene id: 9601:HEXA
uniprot id: A0A2J8UCR3
uniprot id: Q5RC84
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
messages: Lysosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: There are 3 beta-hexosaminidase isozymes: isozyme A (hexosaminidase A) is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); isozyme B (hexosaminidase B) is an homodimer of two beta subunits (two chains A and B); isozyme S (hexosaminidase S) is a homodimer of two alpha subunits. The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site.

9601:FECH
gene id: 9601:FECH
uniprot id: H2NWE9
uniprot id: Q5R7D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9601:HTR2C
gene id: 9601:HTR2C
uniprot id: A0A2J8VAD1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARRB2
gene id: 9601:ARRB2
uniprot id: A0A2J8SPM5
uniprot id: Q5RCR4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via …
messages: Homooligomer; the self-association is mediated by InsP6-binding (Probable). Heterooligomer with ARRB1; the association is mediated by InsP6-binding. Interacts with ADRB2 and CHRM2. Interacts with PDE4A. Interacts with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with CLTC. Interacts with HTR2C. Interacts with CCR5. Interacts with CXCR4. Interacts with SRC. Interacts with DUSP16; the interaction is interrupted by stimulation of AGTR1 and activation of MAPK10. Interacts with CHUK; the interaction is enhanced stimulation of ADRB2. Interacts with RELA. Interacts with MDM2; the interaction is enhanced by activation of GPCRs. Interacts with SLC9A5. Interacts with TRAF6. Interacts with IGF1R. Interacts with ENG. Interacts with KIR2DL1, KIR2DL3 and KIR2DL4. Interacts with LDLR. Interacts with AP2B1. Interacts with C5AR1. Interacts with RAF1. Interacts with MAP2K1. Interacts with MAPK1. Interacts with MAPK10; the interaction enhances MAPK10 activation by MAP3K5. Interacts with MAP2K4; the interaction is enhanced by presence of MAP3K5 and MAPK10. Interacts with MAP3K5. Interacts with AKT1. Interacts with IKBKB and MAP3K14. Interacts with SMO (activated). Interacts with GSK3A and GSK3B. Associates with protein phosphatase 2A (PP2A). Interacts with CXCR4; the interaction is dependent on C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with GPR143. Interacts with HCK and CXCR1 (phosphorylated) (By similarity). Interacts with ACKR3 and ACKR4 (By similarity). Interacts with ARRDC1; the interaction is direct (By similarity). Interacts with GPR61, GPR62 and GPR135 (By similarity). Interacts (via NACHT and LRR domains) with NLRP3; this interaction is direct and inducible by omega-3 polyunsaturated fatty acids (PUFAs) (By similarity). Interacts with FFAR4 (via C-terminus); this interaction is stimulated by long-chain fatty acids (LCFAs) (By similarity).
messages: Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and inhibiting subsequent co-internalization with class A receptors.
messages: Nucleus
messages: Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination (By similarity).
messages: clathrin-coated pit

9601:UCRC
gene id: 9601:UCRC
uniprot id: A0A2J8UUX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TROAP
gene id: 9601:TROAP
uniprot id: A0A2J8SYL8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SATL1
gene id: 9601:SATL1
uniprot id: A0A2J8RJE3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDX5
gene id: 9601:DDX5
uniprot id: Q5R4I9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1, AR, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with NUPR1 (By similarity). Interacts with ERCC6 (By similarity). Interacts with DDX3X in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated (By similarity).
messages: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity).
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation.
messages: Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination (By similarity).
messages: Weakly phosphorylated in the G1/S phase of the cell cycle and much more at G2/M, especially at Thr and Tyr residues.
messages: nucleolus

9601:JMJD6
gene id: 9601:JMJD6
uniprot id: A0A2J8Y1H3
uniprot id: Q5R6G2
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cyt…
messages: Homooligomerizes; requires lysyl-hydroxylase activity. Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65 (By similarity). Interacts with LIAT1 (By similarity). Interacts with CDK9 and CCNT1; the interaction is direct with CDK9 and associates the P-TEFb complex when active. Interacts (via JmjC and N-terminal domains) with BRD4 (via NET domain); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers (By similarity).
messages: Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
messages: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus
messages: nucleoplasm

9601:LSM8
gene id: 9601:LSM8
uniprot id: A0A2J8UPB1
uniprot id: Q5RCP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF420
gene id: 9601:ZNF420
uniprot id: K7EU23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:BBS2
gene id: 9601:BBS2
uniprot id: Q5R9U3
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9601:MOBP
gene id: 9601:MOBP
uniprot id: A0A2J8WY13
uniprot id: A0A2J8WY34
uniprot id: A0A2J8WY58
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CRH
gene id: 9601:CRH
uniprot id: H2PQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9601:CHMP5
gene id: 9601:CHMP5
uniprot id: A0A2J8XIU5
uniprot id: Q5RBR3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome membrane
messages: ISGylated. Isgylation inhibits its interaction with VTA1 (By similarity).
messages: Midbody
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5 (By similarity). Interacts with NOD2 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:MRGPRE
gene id: 9601:MRGPRE
uniprot id: H2NCI4
names: Subcellular Location Annotation
messages: Cell membrane

9601:FRMD7
gene id: 9601:FRMD7
uniprot id: A0A2J8WWW9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XPO6
gene id: 9601:XPO6
uniprot id: H2NQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9601:ACP6
gene id: 9601:ACP6
uniprot id: Q5R8C0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histidine acid phosphatase family.
messages: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
messages: It is uncertain whether Met-1 or Met-8 is the initiator.
messages: Mitochondrion
messages: Monomer.

9601:KHDC3L
gene id: 9601:KHDC3L
uniprot id: H2PJK6
names: Similarity
messages: Belongs to the KHDC1 family.

9601:SRP54
gene id: 9601:SRP54
uniprot id: A0A2J8TI51
uniprot id: Q5R4R6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPM
gene id: 9601:CENPM
uniprot id: A0A663DDW9
uniprot id: H2P4L0
names: Subcellular Location Annotation
messages: Nucleus

9601:NKX2-5
gene id: 9601:NKX2-5
uniprot id: A0A2J8X7I3
uniprot id: A0A2J8X7I4
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C1H1orf174
gene id: 9601:C1H1orf174
uniprot id: H2N9C6
uniprot id: K7ETF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9601:KCNK3
gene id: 9601:KCNK3
uniprot id: A0A6D2W7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9601:ZNF333
gene id: 9601:ZNF333
uniprot id: Q5RD25
names: Subcellular Location Annotation
messages: Nucleus

9601:ARF1
gene id: 9601:ARF1
uniprot id: A0A6D2XZ48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9601:KCTD13
gene id: 9601:KCTD13
uniprot id: A0A6D2XS41
names: Similarity
messages: Belongs to the BACURD family.

9601:KEF63 p07
gene id: 9601:KEF63_p07
uniprot id: A0A0X8E9E5
uniprot id: P92696
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9601:DBT
gene id: 9601:DBT
uniprot id: Q5R8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9601:JOSD1
gene id: 9601:JOSD1
uniprot id: A0A2J8UWL6
uniprot id: Q5R739
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
messages: Interacts with beta-actin/ACTB.
messages: Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BRINP1
gene id: 9601:BRINP1
uniprot id: H2PT80
names: Similarity
messages: Belongs to the BRINP family.

9601:ENOSF1
gene id: 9601:ENOSF1
uniprot id: Q5RAT4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Could be sumoylated.
messages: Mitochondrion
messages: Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism.

9601:MCFD2
gene id: 9601:MCFD2
uniprot id: A0A2J8XDB3
uniprot id: A0A2J8XDJ0
uniprot id: Q5R8Z6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus
messages: Interacts in a calcium-dependent manner with LMAN1.
messages: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC7A5
gene id: 9601:SLC7A5
uniprot id: H2NRQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9601:ATF7IP2
gene id: 9601:ATF7IP2
uniprot id: A0A6D2X4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9601:NEURL4
gene id: 9601:NEURL4
uniprot id: A0A2J8RX06
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC25A51
gene id: 9601:SLC25A51
uniprot id: H2PRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:FBXO46
gene id: 9601:FBXO46
uniprot id: A0A2J8U6Q4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9601:PNLDC1
gene id: 9601:PNLDC1
uniprot id: Q5R6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (By similarity). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (By similarity).
messages: Belongs to the CAF1 family.
messages: Endoplasmic reticulum membrane

9601:KHDC4
gene id: 9601:KHDC4
uniprot id: H2N5F7
names: Similarity
messages: Belongs to the KHDC4 family.

9601:NUCB2
gene id: 9601:NUCB2
uniprot id: H2NE04
names: Similarity
messages: Belongs to the nucleobindin family.

9601:SPDYA
gene id: 9601:SPDYA
uniprot id: A0A6D2Y1Z8
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9601:ALDH18A1
gene id: 9601:ALDH18A1
uniprot id: Q5R6Q0
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9601:GIMAP1
gene id: 9601:GIMAP1
uniprot id: A0A2J8RK30
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9601:GBA
gene id: 9601:GBA
uniprot id: A0A2J8VGD3
uniprot id: Q5R8E3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
messages: Interacts with saposin-C. Interacts with SCARB2. Interacts with TCP1. Interacts with GRN; this interaction prevents aggregation of GBA1-SCARB2 complex via interaction with HSPA1A upon stress (By similarity).
messages: Lysosome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TET3
gene id: 9601:TET3
uniprot id: K7EUU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9601:GPR119
gene id: 9601:GPR119
uniprot id: H2PWS0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:AK6
gene id: 9601:AK6
uniprot id: A0A663D9C4
uniprot id: H2PFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9601:LETM1
gene id: 9601:LETM1
uniprot id: H2PCP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9601:PSMA6
gene id: 9601:PSMA6
uniprot id: A0A2J8TI87
uniprot id: A0A6D2W2A3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:JRKL
gene id: 9601:JRKL
uniprot id: H2NF13
names: Subcellular Location Annotation
messages: Nucleus

9601:DDX47
gene id: 9601:DDX47
uniprot id: H2NGN2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9601:SETD5
gene id: 9601:SETD5
uniprot id: A0A2J8WDV6
uniprot id: A0A2J8WDZ6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KEF63 p11
gene id: 9601:KEF63_p11
uniprot id: P92692
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9601:LOC100443050
gene id: 9601:LOC100443050
uniprot id: A0A8I5U1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:INTS9
gene id: 9601:INTS9
uniprot id: H2PPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9601:KDELR3
gene id: 9601:KDELR3
uniprot id: A0A2J8UWL4
uniprot id: H2P4D5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYL9
gene id: 9601:MYL9
uniprot id: A0A2J8VJH4
uniprot id: Q5RBA4
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
messages: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This chain binds calcium.
messages: cell cortex
messages: cytoskeleton

9601:DPY19L3
gene id: 9601:DPY19L3
uniprot id: Q5RCJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9601:KPNA2
gene id: 9601:KPNA2
uniprot id: Q5R5I8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9601:ASB14
gene id: 9601:ASB14
uniprot id: A0A663D6A8
uniprot id: H2PAF6
names: Caution
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XRCC5
gene id: 9601:XRCC5
uniprot id: Q5R7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9601:TNFSF13
gene id: 9601:TNFSF13
uniprot id: H2NSK1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9601:ARMCX5
gene id: 9601:ARMCX5
uniprot id: Q5RDG2
names: Similarity
messages: Belongs to the eutherian X-chromosome-specific Armcx family.

9601:SLX1A
gene id: 9601:SLX1A
uniprot id: A0A2J8TJW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SGTB
gene id: 9601:SGTB
uniprot id: H2PFP8
names: Similarity
messages: Belongs to the SGT family.

9601:CFLAR
gene id: 9601:CFLAR
uniprot id: A0A2J8WV56
uniprot id: A0A2J8WV64
uniprot id: A0A6D2W5A9
uniprot id: Q5RD56
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity).
messages: Belongs to the peptidase C14A family.
messages: Proteolytically processed by CASP8 generating subunit p43 and p12.
messages: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (By similarity). A proteolytic fragment (p43) stays associated with the DISC (By similarity). Interacts with RIPK1 (By similarity).
messages: The caspase domain lacks the active site residues involved in catalysis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NELFE
gene id: 9601:NELFE
uniprot id: A0A6D2W3J5
uniprot id: H2PIL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9601:SLC35C1
gene id: 9601:SLC35C1
uniprot id: A0A663DI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9601:POLR2E
gene id: 9601:POLR2E
uniprot id: Q5R587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with URI1.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
messages: Nucleus

9601:FOXO3
gene id: 9601:FOXO3
uniprot id: A0A6D2X932
names: Subcellular Location Annotation
messages: Nucleus

9601:GCNT1
gene id: 9601:GCNT1
uniprot id: A0A2J8SU89
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9601:B4GALT4
gene id: 9601:B4GALT4
uniprot id: A0A6D2VWV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9601:SLC2A4
gene id: 9601:SLC2A4
uniprot id: H2NSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9601:TLX1
gene id: 9601:TLX1
uniprot id: A0A2J8XYC7
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCPEP1
gene id: 9601:SCPEP1
uniprot id: H2NTJ6
names: Similarity
messages: Belongs to the peptidase S10 family.

9601:FOLR2
gene id: 9601:FOLR2
uniprot id: K7EVL7
names: Similarity
messages: Belongs to the folate receptor family.

9601:RPL22
gene id: 9601:RPL22
uniprot id: A0A6D2WZC9
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPR31
gene id: 9601:GPR31
uniprot id: H2PKV1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:PLOD3
gene id: 9601:PLOD3
uniprot id: A0A2J8XU82
uniprot id: Q5R6K5
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum lumen
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity).
messages: Rough endoplasmic reticulum
messages: Secreted
messages: The C-terminal domain that mediates lysyl hydroxylase activity is also important for homodimerization.
messages: The N-terminal domain mediates glycosyltransferase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular space

9601:RGS4
gene id: 9601:RGS4
uniprot id: A0A0A0MXL6
uniprot id: Q5R747
names: Function
names: PTM
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated by cyclic GMP-dependent protein kinase.

9601:ZNF101
gene id: 9601:ZNF101
uniprot id: A0A6D2XW66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:CHST4
gene id: 9601:CHST4
uniprot id: A0A2J8VVY0
uniprot id: A0A6D2X3T2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BIN2
gene id: 9601:BIN2
uniprot id: A0A2J8SXS8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MANEAL
gene id: 9601:MANEAL
uniprot id: A0A2J8Y6I1
uniprot id: H2N7X7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100439884
gene id: 9601:LOC100439884
uniprot id: A0A6D2XH37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:APOLD1
gene id: 9601:APOLD1
uniprot id: A0A2J8SQY7
uniprot id: A0A6D2XQK8
names: Caution
names: Similarity
messages: Belongs to the apolipoprotein L family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MDM1
gene id: 9601:MDM1
uniprot id: Q5RC32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
messages: Nucleus
messages: centriole
messages: centrosome

9601:NEMP1
gene id: 9601:NEMP1
uniprot id: Q5RDB4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NEMP family.
messages: Homooligomer. Interacts with RAN-GTP. Interacts with EMD (By similarity).
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Phosphorylation may regulate its interaction with RAN-GTP.
messages: The transmembrane domains are required and sufficient for its oligomerization.
messages: Together with EMD, contributes to nuclear envelope stiffness in germ cells (By similarity). Required for female fertility (By similarity).

9601:NUBP2
gene id: 9601:NUBP2
uniprot id: H2NPQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9601:ATXN1L
gene id: 9601:ATXN1L
uniprot id: K7ETZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9601:LOC100437796
gene id: 9601:LOC100437796
uniprot id: A0A663DDD4
uniprot id: H2NDH6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HTRA2
gene id: 9601:HTRA2
uniprot id: A0A8I5TL58
uniprot id: H2P5Q8
names: Similarity
messages: Belongs to the peptidase S1C family.

9601:MARS
gene id: 9601:MARS
uniprot id: H2NHT5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9601:WASHC2
gene id: 9601:WASHC2
uniprot id: Q5RDC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.
messages: Belongs to the FAM21 family.
messages: Cell membrane
messages: Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5; in the complex interacts (via N-terminus) directly with WASHC1. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VPS35; mediates the association with the retromer CSC complex. Interacts with FKBP15. Interacts with CCDC93, CCDC22, VPS35L; indicative for an association of the WASH core complex with the CCC and retriever complexes (By similarity). Directly interacts with TBC1D23 (By similarity).
messages: Early endosome membrane
messages: The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.

9601:GJD2
gene id: 9601:GJD2
uniprot id: A0A663DG38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:TSHB
gene id: 9601:TSHB
uniprot id: A0A2J8ULP7
uniprot id: A0A6D2WPL0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCL15
gene id: 9601:CCL15
uniprot id: A0A6D2W9S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:THAP5
gene id: 9601:THAP5
uniprot id: A0A2J8TA23
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GTF2F2
gene id: 9601:GTF2F2
uniprot id: H2NJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9601:REEP5
gene id: 9601:REEP5
uniprot id: A0A2J8XEM0
uniprot id: Q5RE33
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Monomer (heart, ventricle). Homodimer (atria, kidney, intestine); maybe disulfide-linked. Homotrimer (heart, ventricle, skeletal muscle, liver). Interacts with ATL1. Interacts with ATL2. Interacts with ATL3. Interacts with CKAP4. Interacts with RTN4. Interacts with ZFYVE27.
messages: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
messages: Sarcoplasmic reticulum membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

9601:FHL1
gene id: 9601:FHL1
uniprot id: A0A2J8WX48
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ERGIC3
gene id: 9601:ERGIC3
uniprot id: Q5R8G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Forms homodimers (By similarity). May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Within the complex, the interaction with ERGIC1 is direct (By similarity). Interacts with ERGIC1/ERGIC32 (By similarity). Interacts with ERGIC2, the interaction is required for the stable expression of both proteins (By similarity). Interacts with MARCHF2 (By similarity). Interacts with SERPINA1/alpha1-antitrypsin and HP/haptoglobin (By similarity).
messages: Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins alpha1-antitrypsin/SERPINA1 and HP/haptoglobin (By similarity).
messages: cis-Golgi network membrane

9601:UCP3
gene id: 9601:UCP3
uniprot id: H2NEM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:TAS2R20
gene id: 9601:TAS2R20
uniprot id: H2NGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:SLC2A5
gene id: 9601:SLC2A5
uniprot id: H2N978
uniprot id: Q5RET7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
messages: Membrane
messages: sarcolemma

9601:CENPT
gene id: 9601:CENPT
uniprot id: A0A2J8VV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9601:SNAP91
gene id: 9601:SNAP91
uniprot id: A0A2J8V2L7
uniprot id: A0A2J8V2L9
uniprot id: A0A2J8V2M0
uniprot id: Q5R4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9601:DYNLL2
gene id: 9601:DYNLL2
uniprot id: A0A6D2WBP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:RPL6
gene id: 9601:RPL6
uniprot id: A0A6D2YC95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9601:CDCA8
gene id: 9601:CDCA8
uniprot id: Q5RBS5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity).
messages: Cytoplasm
messages: May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5. Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1 (By similarity).
messages: Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA.
messages: Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
messages: The C-terminal region (aa 207-280) represents the dimerization motif.
messages: centromere
messages: nucleolus
messages: spindle

9601:FKBP6
gene id: 9601:FKBP6
uniprot id: A0A2J8XV18
uniprot id: A0A2J8XV56
uniprot id: H2PLY7
names: Caution
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DOC2A
gene id: 9601:DOC2A
uniprot id: A0A6D2Y283
names: Subcellular Location Annotation
messages: Membrane

9601:TP53I3
gene id: 9601:TP53I3
uniprot id: A0A2J8VMC7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2D1
gene id: 9601:UBE2D1
uniprot id: H2NAV1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:TRIB2
gene id: 9601:TRIB2
uniprot id: A0A2J8V462
uniprot id: A0A2J8V4D4
uniprot id: Q5R669
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
messages: Cytoplasm
messages: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:ANAPC13
gene id: 9601:ANAPC13
uniprot id: A0A6D2X2X2
uniprot id: Q5RBV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Nucleus
messages: The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

9601:DMRT1
gene id: 9601:DMRT1
uniprot id: H2PSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9601:RPS3
gene id: 9601:RPS3
uniprot id: Q5R465
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the 40S small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRPD. Interacts with PRMT1; the interaction methylates RPS3. Interacts with SUMO1; the interaction sumoylates RPS3. Interacts with UBC9. Interacts with CDK1; the interaction phosphorylates RPS3. Interacts with PRKCD; the interaction phosphorylates RPS3. Interacts with PKB/AKT; the interaction phosphorylates RPS3. Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity. Interacts with UNG; the interaction increases the uracil excision activity of UNG1. Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels. Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion. Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex. Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA. Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus. Interacts (via KH domain) with MDM2 and TP53. Interacts with TRADD. Interacts with CRY1.
messages: Cytoplasm
messages: Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
messages: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.
messages: Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
messages: Ubiquitinated. This is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.
messages: Ufmylated by UFL1.
messages: nucleolus
messages: spindle

9601:BTLA
gene id: 9601:BTLA
uniprot id: A0A2J8W2Y1
uniprot id: H2P9R0
names: Subcellular Location Annotation
messages: Cell membrane

9601:KEF63 p09
gene id: 9601:KEF63_p09
uniprot id: A0A0X8E9E0
uniprot id: P92694
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9601:WNT2
gene id: 9601:WNT2
uniprot id: A0A2J8UPD4
uniprot id: Q2IBE2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:ATL1
gene id: 9601:ATL1
uniprot id: A0A2J8WKG9
uniprot id: Q5R4P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
messages: Endoplasmic reticulum membrane
messages: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.
messages: Golgi apparatus membrane
messages: Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 and RTN4 (via the transmembrane region). Interacts with SPAST; interaction is direct. Interacts with REEP1. Interacts with CPT1C. Interacts with ARL6IP1. Interacts with ZFYVE27.
messages: axon

9601:CSNK1G3
gene id: 9601:CSNK1G3
uniprot id: Q5R4V3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Cytoplasm
messages: Monomer.
messages: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
messages: Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

9601:ATP7A
gene id: 9601:ATP7A
uniprot id: H2PW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9601:CDK6
gene id: 9601:CDK6
uniprot id: A0A6D2X0V6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:ZNF449
gene id: 9601:ZNF449
uniprot id: A0A6D2XEI1
names: Subcellular Location Annotation
messages: Nucleus

9601:TMEM50B
gene id: 9601:TMEM50B
uniprot id: A0A2J8UL11
uniprot id: Q5R4C3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0220 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: May form homotrimers or homodimers.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DOCK9
gene id: 9601:DOCK9
uniprot id: Q5REN3
names: Similarity
messages: Belongs to the DOCK family.

9601:TBX22
gene id: 9601:TBX22
uniprot id: A0A6D2VZJ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:GUCA2B
gene id: 9601:GUCA2B
uniprot id: H2N7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9601:SOX6
gene id: 9601:SOX6
uniprot id: A0A2J8UQ76
uniprot id: A0A2J8UQ96
uniprot id: Q5RCU4
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with DAZAP2 (By similarity). May interact with CENPK (By similarity).
messages: Nucleus
messages: Sumoylation inhibits the transcriptional activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor.

9601:PPM1G
gene id: 9601:PPM1G
uniprot id: H2P6N4
names: Similarity
messages: Belongs to the PP2C family.

9601:FAM126A
gene id: 9601:FAM126A
uniprot id: A0A2J8VE38
uniprot id: Q5RC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9601:METTL23
gene id: 9601:METTL23
uniprot id: A0A2J8Y1G1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SGO1
gene id: 9601:SGO1
uniprot id: A0A2J8U456
uniprot id: A0A2J8U459
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centromere

9601:CEP55
gene id: 9601:CEP55
uniprot id: H2NB17
names: Subcellular Location Annotation
messages: Cytoplasm

9601:CHP1
gene id: 9601:CHP1
uniprot id: A0A2J8S5V4
uniprot id: Q5R7F0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic. N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes (By similarity).
messages: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Membrane
messages: Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B (via the C-terminal end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner. Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH. Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the juxtamembrane region of the cytoplasmic C-terminal domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is critical for growth factor stimulation of the exchanger (By similarity).
messages: Nucleus
messages: Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:SLC7A11
gene id: 9601:SLC7A11
uniprot id: Q5RAG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
messages: Membrane
messages: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

9601:NCAPG
gene id: 9601:NCAPG
uniprot id: H2PCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9601:SLC2A6
gene id: 9601:SLC2A6
uniprot id: H2PTV1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9601:LOC100432171
gene id: 9601:LOC100432171
uniprot id: H2NED1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:KCNA10
gene id: 9601:KCNA10
uniprot id: H2N6F4
names: Subcellular Location Annotation
messages: Membrane

9601:ARF3
gene id: 9601:ARF3
uniprot id: Q5R5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
messages: Golgi apparatus
messages: Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.
messages: perinuclear region

9601:POU4F3
gene id: 9601:POU4F3
uniprot id: H2PGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9601:LOC100450150
gene id: 9601:LOC100450150
uniprot id: A0A6D2WKL7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9601:SLC41A2
gene id: 9601:SLC41A2
uniprot id: H2NIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9601:NSUN7
gene id: 9601:NSUN7
uniprot id: A0A2J8TCY1
uniprot id: H2PD61
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:LIN28A
gene id: 9601:LIN28A
uniprot id: A0A6D2XRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9601:GATA3
gene id: 9601:GATA3
uniprot id: A0A2J8VK88
uniprot id: H2N9Q8
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC9A8
gene id: 9601:SLC9A8
uniprot id: H2P294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9601:FBXW12
gene id: 9601:FBXW12
uniprot id: A0A663D9C3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NCALD
gene id: 9601:NCALD
uniprot id: Q5RAH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the recoverin family.
messages: Interacts with GUCY2D.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

9601:TRIAP1
gene id: 9601:TRIAP1
uniprot id: A0A2J8XK39
names: Caution
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STEAP1
gene id: 9601:STEAP1
uniprot id: H2PMZ0
names: Subcellular Location Annotation
messages: Membrane

9601:SGK1
gene id: 9601:SGK1
uniprot id: A0A2J8X996
uniprot id: A0A2J8X999
uniprot id: A0A2J8X9A2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:PEBP4
gene id: 9601:PEBP4
uniprot id: H2PPT0
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9601:PDE4C
gene id: 9601:PDE4C
uniprot id: A0A2J8T5Z5
uniprot id: A0A2J8T603
uniprot id: A0A2J8T625
uniprot id: A0A2J8T626
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCGB2A2
gene id: 9601:SCGB2A2
uniprot id: H2ND64
names: Subcellular Location Annotation
messages: Secreted

9601:PKMYT1
gene id: 9601:PKMYT1
uniprot id: H2NPW7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:CNIH1
gene id: 9601:CNIH1
uniprot id: Q5RDB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cornichon family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA (By similarity).
messages: Involved in the selective transport and maturation of TGF-alpha family proteins.

9601:HSPA1A
gene id: 9601:HSPA1A
uniprot id: Q5R7D3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of the CatSper complex (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with DNAJC9 (via J domain). Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Cytoplasm
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: Nucleus
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

9601:GNAI3
gene id: 9601:GNAI3
uniprot id: H2N6H9
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9601:FAM19A3
gene id: 9601:FAM19A3
uniprot id: A0A663DHF1
uniprot id: H2N6C3
names: Caution
names: Similarity
messages: Belongs to the TAFA family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MVB12A
gene id: 9601:MVB12A
uniprot id: A0A8I5TI12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9601:VIL1
gene id: 9601:VIL1
uniprot id: H2P8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9601:SNCA
gene id: 9601:SNCA
uniprot id: A0A6D2Y785
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9601:ACO1
gene id: 9601:ACO1
uniprot id: Q5R5I1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9601:DEUP1
gene id: 9601:DEUP1
uniprot id: H2NEY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9601:PLA1A
gene id: 9601:PLA1A
uniprot id: A0A2J8W280
uniprot id: Q5RBQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (By similarity). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity).
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM241A
gene id: 9601:FAM241A
uniprot id: A0A2J8XQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9601:LOC100456732
gene id: 9601:LOC100456732
uniprot id: A0A2J8V9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9601:RPP21
gene id: 9601:RPP21
uniprot id: A0A2J8SJL0
uniprot id: A0A6D2Y4E7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RTCB
gene id: 9601:RTCB
uniprot id: H2P460
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9601:RFTN2
gene id: 9601:RFTN2
uniprot id: Q5R458
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor mediated-signaling.

9601:HPRT1
gene id: 9601:HPRT1
uniprot id: H2PWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9601:DDX52
gene id: 9601:DDX52
uniprot id: H2NTH0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9601:POFUT2
gene id: 9601:POFUT2
uniprot id: A0A2J8RSG1
uniprot id: A0A6D2WL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9601:RANBP6
gene id: 9601:RANBP6
uniprot id: A0A663DH44
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUDT16L1
gene id: 9601:NUDT16L1
uniprot id: A0A6D2WPC0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPVL
gene id: 9601:CPVL
uniprot id: Q5RFE4
names: Function
names: Similarity
messages: Belongs to the peptidase S10 family.
messages: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

9601:ADGRG1
gene id: 9601:ADGRG1
uniprot id: Q5RCB2
uniprot id: Q5REI4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9601:ARL6IP5
gene id: 9601:ARL6IP5
uniprot id: A0A2J8SWB6
uniprot id: Q5R4X8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with ARL6. Interacts with prenylated RAB1A and RAB3A. Interacts with SLC1A1/EAAC1. Interacts with RTN2 (via first transmembrane domain). Does not interact with VAMP1, VAMP2 or VAMP3.
messages: Membrane
messages: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:LLPH
gene id: 9601:LLPH
uniprot id: A0A6D2WHD0
names: Similarity
messages: Belongs to the learning-associated protein family.

9601:LOC103888721
gene id: 9601:LOC103888721
uniprot id: K7EVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:PYCR1
gene id: 9601:PYCR1
uniprot id: A0A2J8XZ53
uniprot id: A0A6D2WGU6
uniprot id: Q5R9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Homodecamer; composed of 5 homodimers. Interacts with LTO1.
messages: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
messages: Mitochondrion

9601:ANO10
gene id: 9601:ANO10
uniprot id: A0A6D2XTL7
uniprot id: H2PB11
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:DPCD
gene id: 9601:DPCD
uniprot id: A0A663D5D6
uniprot id: H2NBD4
names: Similarity
messages: Belongs to the DPCD family.

9601:TMEM14A
gene id: 9601:TMEM14A
uniprot id: A0A6D2VUR2
names: Similarity
messages: Belongs to the TMEM14 family.

9601:NCR3
gene id: 9601:NCR3
uniprot id: A0A2J8R4U2
uniprot id: A0A663DHJ3
uniprot id: H2PII6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALG6
gene id: 9601:ALG6
uniprot id: Q5NVS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

9601:KLHL20
gene id: 9601:KLHL20
uniprot id: Q5R7B8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with PDZ-RhoGEF/ARHGEF11, DAPK1, PML and CORO7. Interacts with F-actin. Interacts with IFN-gamma (IFNG) (By similarity). Interacts (via kelch repeats) with IVNS1ABP (via kelch repeats); this interaction blocks the assembly of CUL3-KLHL20 complex (By similarity).
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity).
messages: axon
messages: dendrite
messages: perinuclear region
messages: trans-Golgi network

9601:LOC100448298
gene id: 9601:LOC100448298
uniprot id: A0A6D2Y4L1
names: Subcellular Location Annotation
messages: Membrane

9601:NAA50
gene id: 9601:NAA50
uniprot id: A0A2J8W2J7
uniprot id: A0A2J8W2L0
uniprot id: Q5RF28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Component of the N-terminal acetyltransferase E (NatE) complex at least composed of NAA10, NAA15 and NAA50 (By similarity). Interacts with NAA10 (By similarity). Interacts with NAA15 (By similarity). Predominantly interacts with NAA15 in the N-terminal acetyltransferase A complex (NatA complex); the interactions reduce the acetylation activity of the NatA complex (By similarity). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (By similarity). Within the complex interacts with NAA15 (By similarity). Its capacity to interact with the NatA complex is reduced by HYPK (By similarity). Interacts with NAA35 (By similarity).
messages: Cytoplasm
messages: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). Autoacetylates in vivo (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity). Does not influence the acetyltransferase activity of NAA10 (By similarity). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100437111
gene id: 9601:LOC100437111
uniprot id: K7EUD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9601:CNTNAP1
gene id: 9601:CNTNAP1
uniprot id: H2NTZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9601:EIF4E2
gene id: 9601:EIF4E2
uniprot id: A0A2J8TQ49
uniprot id: A0A2J8TQ72
uniprot id: Q5R4J0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9601:LOC100449138
gene id: 9601:LOC100449138
uniprot id: H2PVC9
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9601:RCBTB2
gene id: 9601:RCBTB2
uniprot id: A0A2J8VSE3
uniprot id: Q5RCZ7
names: Caution
names: Domain
names: Subcellular Location Annotation
messages: The BTB domain might play a role in targeting to acrosomal vesicles.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: acrosome

9601:HSPE1
gene id: 9601:HSPE1
uniprot id: H2NVF2
names: Similarity
messages: Belongs to the GroES chaperonin family.

9601:PLXNA4
gene id: 9601:PLXNA4
uniprot id: A0A6D2WJF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:USP44
gene id: 9601:USP44
uniprot id: A0A6D2XJ28
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9601:SP2
gene id: 9601:SP2
uniprot id: A0A663DCT5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NCR3LG1
gene id: 9601:NCR3LG1
uniprot id: Q5RFR2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Monomer (By similarity). Interacts specifically with NCR3.
messages: The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
messages: Triggers NCR3-dependent natural killer cell activation.

9601:KCTD9
gene id: 9601:KCTD9
uniprot id: A0A663DFX0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MFSD2A
gene id: 9601:MFSD2A
uniprot id: A0A663DBA4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NMB
gene id: 9601:NMB
uniprot id: A0A2J8SG70
uniprot id: A0A663DCK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: neuron projection

9601:TM4SF18
gene id: 9601:TM4SF18
uniprot id: A0A6D2WAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9601:RAE1
gene id: 9601:RAE1
uniprot id: A0A2J8TXI7
uniprot id: Q5RF99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat rae1 family.
messages: Cytoplasm
messages: Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (By similarity). Interacts with NUP98 (By similarity). Interacts with MYCBP2 (By similarity). Interacts with USP11 (By similarity).
messages: Nucleus
messages: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle pole

9601:AAMP
gene id: 9601:AAMP
uniprot id: A0A2J8TTW9
uniprot id: A0A2J8TTZ1
uniprot id: Q5RCG7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STAT5B
gene id: 9601:STAT5B
uniprot id: H2NU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9601:ELK4
gene id: 9601:ELK4
uniprot id: A0A6D2XJE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:GCLM
gene id: 9601:GCLM
uniprot id: A0A663D9I1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9601:SORBS3
gene id: 9601:SORBS3
uniprot id: A0A2J8X4M9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSMA8
gene id: 9601:PSMA8
uniprot id: A0A2J8XG40
uniprot id: A0A2J8XGG2
uniprot id: A0A6D2WNE4
uniprot id: H2NW32
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGFR1
gene id: 9601:FGFR1
uniprot id: A0A2J8TP16
uniprot id: A0A2J8TP40
uniprot id: A0A2J8TP87
uniprot id: A0A663D861
uniprot id: H2PQ36
uniprot id: Q5R8Q3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Vesicle
messages: cytosol

9601:MET
gene id: 9601:MET
uniprot id: A0A0A0MXS4
uniprot id: A0A2J8UPG2
uniprot id: Q2IBD8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9601:VPS16
gene id: 9601:VPS16
uniprot id: H2P1D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9601:TMBIM4
gene id: 9601:TMBIM4
uniprot id: Q5R8M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9601:TADA3
gene id: 9601:TADA3
uniprot id: Q5R5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGG1 family.
messages: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
messages: Nucleus
messages: The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex (By similarity). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity).

9601:ERN2
gene id: 9601:ERN2
uniprot id: A0A2J8TJ73
uniprot id: H2NQF3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:LOC100453850
gene id: 9601:LOC100453850
uniprot id: H2NFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TOM1
gene id: 9601:TOM1
uniprot id: Q5NVJ9
names: Similarity
messages: Belongs to the TOM1 family.

9601:ZNF143
gene id: 9601:ZNF143
uniprot id: A0A6D2W8J4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CACNG1
gene id: 9601:CACNG1
uniprot id: H2NUI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9601:CDC25B
gene id: 9601:CDC25B
uniprot id: A0A2J8RZU3
uniprot id: H2P1B6
names: Caution
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC17A9
gene id: 9601:SLC17A9
uniprot id: H2P2K4
names: Subcellular Location Annotation
messages: Membrane

9601:ACSM4
gene id: 9601:ACSM4
uniprot id: H2NGC7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9601:PSMB4
gene id: 9601:PSMB4
uniprot id: H2N5V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9601:DLEU7
gene id: 9601:DLEU7
uniprot id: A0A2J8VS81
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZDHHC3
gene id: 9601:ZDHHC3
uniprot id: A0A2J8WXF4
uniprot id: A0A663DHF9
uniprot id: A0A8I5YKC8
uniprot id: A0A8I5YU88
uniprot id: H2PAZ4
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSMA7
gene id: 9601:PSMA7
uniprot id: Q5RDH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIF1A. Interacts with RAB7A. Interacts with PRKN. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

9601:CCDC91
gene id: 9601:CCDC91
uniprot id: Q5RCA7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts with GGA1, GGA2 and AP1G1.
messages: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes.
messages: Membrane
messages: trans-Golgi network
messages: trans-Golgi network membrane

9601:SLITRK5
gene id: 9601:SLITRK5
uniprot id: H2NK44
names: Similarity
messages: Belongs to the SLITRK family.

9601:AQP8
gene id: 9601:AQP8
uniprot id: A0A2J8TJC9
uniprot id: H2NQG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100448759
gene id: 9601:LOC100448759
uniprot id: K7EW10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9601:MAL2
gene id: 9601:MAL2
uniprot id: Q5RAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MAL family.
messages: Cell membrane
messages: Interacts with TPD52L2.
messages: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity).

9601:HSCB
gene id: 9601:HSCB
uniprot id: H2P3X7
names: Similarity
messages: Belongs to the HscB family.

9601:CPT1C
gene id: 9601:CPT1C
uniprot id: Q5RBI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:MMP9
gene id: 9601:MMP9
uniprot id: H2P256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9601:PTBP2
gene id: 9601:PTBP2
uniprot id: A0A2J8VCP7
uniprot id: A0A2J8VCQ5
uniprot id: A0A663DEY8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RETN
gene id: 9601:RETN
uniprot id: A0A663D5F8
uniprot id: H2NXB1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100459927
gene id: 9601:LOC100459927
uniprot id: A0A8I5TJ98
names: Similarity
messages: Belongs to the thioredoxin family.

9601:LYZL6
gene id: 9601:LYZL6
uniprot id: H2NTE7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9601:RNASE1
gene id: 9601:RNASE1
uniprot id: A0A2J8TSW9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9601:EIF5
gene id: 9601:EIF5
uniprot id: A0A2J8SZJ2
uniprot id: Q5R4L0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
messages: Interacts with FMR1; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with EIF2S2 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZDHHC14
gene id: 9601:ZDHHC14
uniprot id: A0A6D2WEW7
uniprot id: H2PKQ0
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MMP14
gene id: 9601:MMP14
uniprot id: Q5RES1
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
messages: Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling.
messages: Melanosome
messages: Membrane
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Tyrosine phosphorylated by PKDCC/VLK.

9601:PPIL6
gene id: 9601:PPIL6
uniprot id: A0A6D2W103
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC26
gene id: 9601:CDC26
uniprot id: H2PT40
uniprot id: Q5RAQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
messages: Nucleus
messages: V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

9601:CAMK1G
gene id: 9601:CAMK1G
uniprot id: A0A6D2Y1I9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:MAB21L1
gene id: 9601:MAB21L1
uniprot id: H2NJL5
names: Similarity
messages: Belongs to the mab-21 family.

9601:LTBR
gene id: 9601:LTBR
uniprot id: Q5RDW2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:IL18BP
gene id: 9601:IL18BP
uniprot id: A0A2J8V251
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHIA
gene id: 9601:CHIA
uniprot id: A0A2J8UM66
uniprot id: A0A2J8UM70
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TSTA3
gene id: 9601:TSTA3
uniprot id: Q5RBE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Homodimer.

9601:HP
gene id: 9601:HP
uniprot id: Q5R5F6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
messages: Belongs to the peptidase S1 family.
messages: Secreted
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3 (By similarity).
messages: The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.

9601:GLUD1
gene id: 9601:GLUD1
uniprot id: H2NC59
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9601:SCAMP5
gene id: 9601:SCAMP5
uniprot id: Q5R5Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAMP family. SCAMP5 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 (By similarity).
messages: Recycling endosome membrane
messages: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).
messages: synaptic vesicle membrane
messages: trans-Golgi network membrane

9601:LOC100449435
gene id: 9601:LOC100449435
uniprot id: H2NEA9
names: Subcellular Location Annotation
messages: Membrane

9601:PAPSS2
gene id: 9601:PAPSS2
uniprot id: H2NAX1
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9601:PAMR1
gene id: 9601:PAMR1
uniprot id: Q5RDI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity.
messages: Belongs to the peptidase S1 family.
messages: May play a role in regeneration of skeletal muscle.
messages: Secreted

9601:ZC3H11A
gene id: 9601:ZC3H11A
uniprot id: Q5REG6
names: Function
names: Subunit
messages: Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.
messages: Involved in nuclear mRNA export; probably mediated by association with the TREX complex.

9601:SLC44A2
gene id: 9601:SLC44A2
uniprot id: Q5R5L9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter.
messages: Interacts with COCH.
messages: Membrane
messages: N-glycosylated.

9601:EFNB2
gene id: 9601:EFNB2
uniprot id: H2NK99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:KAT8
gene id: 9601:KAT8
uniprot id: H2NQS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9601:LOC100458142
gene id: 9601:LOC100458142
uniprot id: H2NYW8
uniprot id: K7EUR0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:EBF2
gene id: 9601:EBF2
uniprot id: H2PPV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9601:CEBPZ
gene id: 9601:CEBPZ
uniprot id: H2P6H4
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9601:LOC100434086
gene id: 9601:LOC100434086
uniprot id: A0A8I5T0U4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9601:HPGD
gene id: 9601:HPGD
uniprot id: A0A2J8STG7
uniprot id: H2PES5
names: Caution
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SYNGR4
gene id: 9601:SYNGR4
uniprot id: H2NZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9601:GRB2
gene id: 9601:GRB2
uniprot id: A0A2J8Y0M0
uniprot id: Q5R4J7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
messages: Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (By similarity). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1. Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts with phosphorylated MET (By similarity). Interacts with phosphorylated TOM1L1 (By similarity). Interacts with the phosphorylated C-terminus of SH2B2 (By similarity). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity). Interacts with NISCH, PTPNS1 and REPS2 (By similarity). Interacts with syntrophin SNTA1 (By similarity). Interacts (via SH3 domains) with REPS1 (By similarity). Interacts (via SH3 domains) with PIK3C2B. Interacts with CBL and CBLB (By similarity). Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (By similarity). Interacts with PTPN11 (By similarity). Interacts with PRNP (By similarity). Interacts with RALGPS1. Interacts with HCST (By similarity). Interacts with KDR (By similarity). Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts with GAPT and PTPRE. Interacts (via SH2 domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts with ADAM15 (By similarity). Interacts with THEMIS2 (By similarity). Interacts (via SH2 domain) with AXL (phosphorylated). Interacts (via SH2 domain) with KIT (phosphorylated). Interacts with PTPRJ and BCR. Interacts with PTPN23. Interacts with FLT4 (tyrosine phosphorylated). Interacts with EPHB1 and SHC1…
messages: Belongs to the GRB2/sem-5/DRK family.
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus
messages: The SH3 domains mediate interaction with RALGPS1 and SHB.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100444723
gene id: 9601:LOC100444723
uniprot id: H2PIZ1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9601:MDH1B
gene id: 9601:MDH1B
uniprot id: Q5RBA7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9601:GAREM1
gene id: 9601:GAREM1
uniprot id: H2NW54
names: Similarity
messages: Belongs to the GAREM family.

9601:USE1
gene id: 9601:USE1
uniprot id: H2NXZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SLC22A18
gene id: 9601:SLC22A18
uniprot id: A0A6D2WRP1
names: Subcellular Location Annotation
messages: Membrane

9601:PDZK1IP1
gene id: 9601:PDZK1IP1
uniprot id: Q5RA41
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PDZK1. Forms a heterodimer with SLC5A2; this interaction enhances SLC5A2 transporter activity over a hundred-fold.
messages: Membrane

9601:MGRG1
gene id: 9601:MGRG1
uniprot id: A0A663DGI5
uniprot id: H2NDZ4
uniprot id: W8W3E8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSMC5
gene id: 9601:PSMC5
uniprot id: A0A663DEQ3
uniprot id: H2NUF1
uniprot id: Q5R9X8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FBRS
gene id: 9601:FBRS
uniprot id: A0A2J8TKK7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TXNL4B
gene id: 9601:TXNL4B
uniprot id: A0A6D2W590
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9601:NMD3
gene id: 9601:NMD3
uniprot id: Q5RC82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with pre-60S ribosomal particles.
messages: Nucleus

9601:GRIA3
gene id: 9601:GRIA3
uniprot id: A0A2J8WWI5
uniprot id: A0A6D2X629
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9601:SDCCAG3
gene id: 9601:SDCCAG3
uniprot id: H2PTY7
names: Similarity
messages: Belongs to the ENTR1 family.

9601:CSNK2B
gene id: 9601:CSNK2B
uniprot id: A0A8I5YMM5
uniprot id: H2PIJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9601:STAR
gene id: 9601:STAR
uniprot id: H2PQ29
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9601:EFS
gene id: 9601:EFS
uniprot id: H2NKS9
names: Similarity
messages: Belongs to the CAS family.

9601:ANP32A
gene id: 9601:ANP32A
uniprot id: K7EVL6
names: Similarity
messages: Belongs to the ANP32 family.

9601:MAN2A1
gene id: 9601:MAN2A1
uniprot id: H2PG85
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9601:VOPP1
gene id: 9601:VOPP1
uniprot id: A0A2J8U2Z5
uniprot id: Q5RDG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SIM1
gene id: 9601:SIM1
uniprot id: A0A6D2XMD1
names: Subcellular Location Annotation
messages: Nucleus

9601:KCNS1
gene id: 9601:KCNS1
uniprot id: A0A2J8XVU4
uniprot id: A4K2V2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

9601:MMP26
gene id: 9601:MMP26
uniprot id: A0A6D2XG49
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:FAM124A
gene id: 9601:FAM124A
uniprot id: Q5RA50
names: Similarity
messages: Belongs to the FAM124 family.

9601:ZBTB17
gene id: 9601:ZBTB17
uniprot id: A0A2J8S923
uniprot id: A0A2J8S934
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100445948
gene id: 9601:LOC100445948
uniprot id: A0A0A0MXS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:TVP23A
gene id: 9601:TVP23A
uniprot id: A0A6D2WR17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9601:CC2D2B
gene id: 9601:CC2D2B
uniprot id: A0A6D2XQF8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNX17
gene id: 9601:SNX17
uniprot id: Q5R4A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Monomer (By similarity). Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif). Interacts with CCDC22, CCDC93, VPS26C and VPS35L; the interaction with VPS26C is direct and associates SNX17 with the retriever and CCC complexes (By similarity).
messages: The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
messages: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.

9601:MIS12
gene id: 9601:MIS12
uniprot id: A0A2J8R7R8
uniprot id: Q5R9W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: kinetochore

9601:MAP3K14
gene id: 9601:MAP3K14
uniprot id: A0A6D2XA55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9601:APTX
gene id: 9601:APTX
uniprot id: A0A2J8XIM7
uniprot id: A0A2J8XIQ3
uniprot id: A0A2J8XIZ6
uniprot id: A0A6D2Y197
uniprot id: H2PRY2
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus
messages: nucleoplasm

9601:MTF2
gene id: 9601:MTF2
uniprot id: A0A2J8VCW1
uniprot id: A0A2J8VCW2
uniprot id: Q5R7T9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP. Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19 or MTF2; PHF19 and MTF2 stabilize the dimeric structure which enhances PRC2 interaction with chromatin.
messages: Belongs to the Polycomblike family.
messages: Nucleus
messages: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (By similarity). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
messages: The Tudor domain recognizes and binds H3K36me3.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VPS37C
gene id: 9601:VPS37C
uniprot id: Q5R9T2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55 (By similarity).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity).
messages: Late endosome membrane
messages: Phosphorylated by TBK1.

9601:SYT14
gene id: 9601:SYT14
uniprot id: H2N3T5
names: Similarity
messages: Belongs to the synaptotagmin family.

9601:NCDN
gene id: 9601:NCDN
uniprot id: A0A2J8Y6U7
uniprot id: A0A6D2VYJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C17H17orf49
gene id: 9601:C17H17orf49
uniprot id: A0A2J8RX67
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:INMT
gene id: 9601:INMT
uniprot id: Q5RFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity).
messages: Cytoplasm
messages: Monomer.

9601:CDK14
gene id: 9601:CDK14
uniprot id: A0A2J8WK30
uniprot id: H2PMY4
uniprot id: Q5R6M2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:ZNF620
gene id: 9601:ZNF620
uniprot id: A0A2J8WY33
uniprot id: Q5RB33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KAT5
gene id: 9601:KAT5
uniprot id: A0A2J8TZK2
uniprot id: A0A2J8TZK4
uniprot id: A0A2J8TZK7
uniprot id: H2NCU4
uniprot id: Q5RBG4
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase and acetyltransferase activities are activated by phosphorylation and autoacetylation. Autoacetylation activates the histone acetyltransferase activity.
messages: Autoacetylated. Autoacetylation is required for histone acetyltransferase activity. Autoacetylation at Lys-275 is facilitated by interaction with EP300/p300: it prevents ubiquitination and subsequent degradation by the proteasome and promotes acetylation of target proteins. Deacetylated by HDAC3 and SIRT1. Deacetylation by HDAC3 promotes its ubiquitination and cytoplasmic localization.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks. Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes. The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby prom…
messages: Chromosome
messages: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (By similarity). KAT5/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC. Interacts with ATM. Interacts with JADE1. Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7. Interacts with the cytoplasmic tail of APP and APBB1/FE65. Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex (By similarity). Interacts with FOXP3 (By similarity). Interacts with ZBTB49 (By similarity). Interacts with SRF (By similarity). Interacts with ATF3; promoting autoacetylation and deubiquitination by USP7. Interacts with EP300/p300; interaction promotes KAT5 autoacetylation. Interacts with PRKDC; interaction is impaired following KAT5 sumoylation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher activity. Phosphorylation at Ser-90 by CDK1 or CDK9 is a prerequisite for phosphorylation at Ser-86 by GSK3. Phosphorylation at Ser-86 by GSK3 (GSK3A or GSK3B) activates acetyltransferase and acyltransferase activities. Phosphorylation at Ser-90 by CDK9 promotes KAT5 recruitment to chromatin. Phosphorylation by VRK1 following DNA damage promotes KAT5 association with chromatin and histone acetyltransferase activity.
messages: Sumoylated by UBE2I at Lys-378 and Lys-399, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies. Sumoylation with SUMO2 by PIAS4 at Lys-378 promotes repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). Sumoylation by PIAS4 impairs interaction with PRKDC, inhibiting non-homologous end joining (NHEJ)-mediated repair of DSBs, thereby facilitating HR. Desumoylated by SENP3.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by MDM2, leading to its proteasome-dependent degradation. Ubiquitination is prevented by autoacetylation at Lys-275. Ubiquitinated following deacetylation by HDAC3, leading to cytoplasmic localization. Deubiquitinated by USP7 following interaction with ATF3, promoting its stabilization.
messages: kinetochore
messages: nucleolus
messages: perinuclear region
messages: spindle pole

9601:PHF1
gene id: 9601:PHF1
uniprot id: H2PIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9601:GNG3
gene id: 9601:GNG3
uniprot id: H2ND45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9601:KRT31
gene id: 9601:KRT31
uniprot id: H2NU40
names: Similarity
messages: Belongs to the intermediate filament family.

9601:NGRN
gene id: 9601:NGRN
uniprot id: A0A0A0MXP2
uniprot id: Q5R7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Nucleus
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
messages: Secreted

9601:ETS2
gene id: 9601:ETS2
uniprot id: A0A8I3B0M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9601:SLC45A1
gene id: 9601:SLC45A1
uniprot id: H2N987
names: Subcellular Location Annotation
messages: Membrane

9601:MAP1LC3B
gene id: 9601:MAP1LC3B
uniprot id: A0A2J8T9C9
names: Similarity
messages: Belongs to the ATG8 family.

9601:AKAIN1
gene id: 9601:AKAIN1
uniprot id: A0A2J8XGU5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UQCRQ
gene id: 9601:UQCRQ
uniprot id: Q5R597
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with BRAWNIN (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

9601:RBX1
gene id: 9601:RBX1
uniprot id: H2P4I3
names: Similarity
messages: Belongs to the RING-box family.

9601:GLT6D1
gene id: 9601:GLT6D1
uniprot id: H2PTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9601:KLK7
gene id: 9601:KLK7
uniprot id: A0A2J8U972
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PICALM
gene id: 9601:PICALM
uniprot id: A0A2J8S9L0
uniprot id: A0A2J8S9L2
uniprot id: A0A2J8S9M0
uniprot id: A0A8I5TGI1
uniprot id: A0A8I5U1V8
uniprot id: H2NEV6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC20A1
gene id: 9601:SLC20A1
uniprot id: Q5R9L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (By similarity).

9601:RAD17
gene id: 9601:RAD17
uniprot id: Q5R652
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rad17/RAD24 family.
messages: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity).
messages: Nucleus
messages: Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex (By similarity).
messages: Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4 (By similarity).

9601:FMO2
gene id: 9601:FMO2
uniprot id: Q5REK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:KPNA6
gene id: 9601:KPNA6
uniprot id: A0A2J8Y7D1
uniprot id: Q5RBV0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the importin alpha family.
messages: Forms a complex with importin subunit beta-1. Interacts with ZIC3 (By similarity).
messages: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Functions in nuclear protein import.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AGMAT
gene id: 9601:AGMAT
uniprot id: H2N8Z3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9601:ABHD3
gene id: 9601:ABHD3
uniprot id: H2NW09
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9601:PRKAB1
gene id: 9601:PRKAB1
uniprot id: A0A2J8XK82
uniprot id: Q5R801
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
messages: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
messages: The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C5H5orf58
gene id: 9601:C5H5orf58
uniprot id: A0A2J8X790
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C19H19orf66
gene id: 9601:C19H19orf66
uniprot id: A0A6D2XD96
uniprot id: H2NXI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LTB
gene id: 9601:LTB
uniprot id: A0A2J8R4U7
uniprot id: A0A2J8R4Y0
names: Caution
names: Similarity
messages: Belongs to the tumor necrosis factor family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLFN12L
gene id: 9601:SLFN12L
uniprot id: Q5RCZ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Schlafen family.
messages: It is uncertain whether Met-1 or Met-33 is the initiator.
messages: Membrane

9601:NOG
gene id: 9601:NOG
uniprot id: H2NTK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9601:CLDN23
gene id: 9601:CLDN23
uniprot id: A0A2J8X3P5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:PLAC1
gene id: 9601:PLAC1
uniprot id: H2PWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9601:SLC37A1
gene id: 9601:SLC37A1
uniprot id: A0A6D2VV81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9601:TSTD2
gene id: 9601:TSTD2
uniprot id: A0A2J8WNH0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNOT2
gene id: 9601:CNOT2
uniprot id: Q5R643
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9601:ADAM7
gene id: 9601:ADAM7
uniprot id: A0A2J8X4W9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:RGS1
gene id: 9601:RGS1
uniprot id: H2N4C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9601:LOC100438871
gene id: 9601:LOC100438871
uniprot id: A0A7R8GUU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:UBALD1
gene id: 9601:UBALD1
uniprot id: A0A6D2Y3D0
names: Similarity
messages: Belongs to the UBALD family.

9601:SDE2
gene id: 9601:SDE2
uniprot id: Q5RET9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDE2 family.
messages: Both SDE2-UBL and the mature SDE2 are polyubiquitinated.
messages: Cytoplasm
messages: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity).
messages: Interacts (via PIP-box) with PCNA; the interaction is direct and prevents ultraviolet light induced monoubiquitination of PCNA (By similarity). Interacts with FBL/fibrillarin (By similarity). Interacts with CACTIN (By similarity). Interacts with SF3B1 (By similarity). Interacts with U2AF1 (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity).
messages: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
messages: The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.
messages: The SAP domain is necessary for specific binding to DNA.
messages: The propeptide displays a ubiquitin-like fold.
messages: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner.

9601:SLC7A8
gene id: 9601:SLC7A8
uniprot id: Q5RAE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cytoplasm
messages: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
messages: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).

9601:ISCA2
gene id: 9601:ISCA2
uniprot id: A0A2J8T403
uniprot id: Q5R788
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF174
gene id: 9601:ZNF174
uniprot id: A0A2J8S7L5
uniprot id: A0A6D2X4K3
names: Subcellular Location Annotation
messages: Nucleus

9601:SERPINA1
gene id: 9601:SERPINA1
uniprot id: A0A2J8TLQ5
uniprot id: Q5RCW5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).
messages: Interacts with CELA2A (By similarity). Interacts with ERGIC3 and LMAN1/ERGIC53 (By similarity). Interacts with PRSS1/Trypsin (By similarity).
messages: Plasma.
messages: Secreted
messages: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CPNE5
gene id: 9601:CPNE5
uniprot id: A0A2J8Y3L8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:QSOX1
gene id: 9601:QSOX1
uniprot id: A0A0A0MXL5
uniprot id: H2N4I1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
messages: Golgi apparatus membrane
messages: Monomer.
messages: N-glycosylated. O-glycosylated on Thr and Ser residues.
messages: Secreted

9601:TSC22D4
gene id: 9601:TSC22D4
uniprot id: H2PLN5
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9601:TMEM43
gene id: 9601:TMEM43
uniprot id: A0A8I5U4C5
uniprot id: Q5R9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM43 family.
messages: Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway. Interacts with CARD10 (By similarity). Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (By similarity).
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (By similarity). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (By similarity).
messages: Membrane
messages: Nucleus inner membrane

9601:MRPS33
gene id: 9601:MRPS33
uniprot id: A0A2J8V359
uniprot id: A0A6D2XDA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BANF1
gene id: 9601:BANF1
uniprot id: A0A2J8TZT0
uniprot id: Q5RBU9
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BAF family.
messages: Chromosome
messages: Cytoplasm
messages: Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA.
messages: Homodimer. Heterodimerizes with BANF2. Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A). Binds non-specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM domain-containing nuclear proteins such as LEMD3/MAN1, TMPO/LAP2 and EMD (emerin). Interacts with ANKLE1 (via LEM domain); the interaction may favor BANF1 dimerization. Interacts with CRX and LMNA (lamin-A). Binds linker histone H1.1 and core histones H3. Interacts with LEMD2 (via LEM domain). Interacts with PARP1; interaction takes place in response to oxidative DNA damage.
messages: LEM domain proteins bind centrally on the BAF dimer.
messages: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy. In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication.
messages: Nucleus
messages: Nucleus envelope
messages: Ser-4 is the major site of phosphorylation as compared to Thr-2 and Thr-3. Phosphorylation on Thr-2; Thr-3 and Ser-4 disrupts its ability to bind DNA and reduces its ability to bind LEM domain-containing proteins. Non phosphorylated BAF seems to enhance binding between EMD and LMNA. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with ANKLE2/LEM4 during mitotic exit, leading to mitotic nuclear envelope reassembly.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RAB8B
gene id: 9601:RAB8B
uniprot id: A0A2J8T8J4
uniprot id: Q5REC9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP (By similarity). Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2 (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Thr-72 disrupts these interactions (By similarity).
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).
messages: phagosome membrane

9601:CMTM3
gene id: 9601:CMTM3
uniprot id: A0A2J8VU81
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GLS
gene id: 9601:GLS
uniprot id: A0A2J8WVT5
uniprot id: H2P854
names: Similarity
messages: Belongs to the glutaminase family.

9601:ZRANB2
gene id: 9601:ZRANB2
uniprot id: Q5R580
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZRANB2 family.
messages: Interacts with the C-terminal half of SNRP70/U1-70K, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
messages: Nucleus
messages: Phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).
messages: The RanBP2-type zinc fingers mediate binding to RNA.

9601:P4HA2
gene id: 9601:P4HA2
uniprot id: A0A2J8XDW3
uniprot id: A0A6D2XR13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9601:S100A10
gene id: 9601:S100A10
uniprot id: A0A2J8VFE1
names: Caution
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RSAD2
gene id: 9601:RSAD2
uniprot id: Q5RCW8
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Lys-6'-linked polyubiquitination at Lys-206 leads to RSAD2 protein degradation.
messages: Acetylated by HAT1. HAT1-mediated acetylation of Lys-197 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation.
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: By interferon type I, type II and LPS.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer. Interacts with IRAK1 and TRAF6. Interacts with FPPS. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus).
messages: IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold.
messages: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
messages: Lipid droplet
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: The N-terminal region (1-42) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet.

9601:LOC100456237
gene id: 9601:LOC100456237
uniprot id: A0A6D2XLR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9601:EEF2
gene id: 9601:EEF2
uniprot id: Q5R8Z3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2.
messages: Cytoplasm
messages: Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
messages: Proteolytically processed at two sites following phosphorylation by CSK.
messages: SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.

9601:KCNJ14
gene id: 9601:KCNJ14
uniprot id: A0A6D2X6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9601:LEUTX
gene id: 9601:LEUTX
uniprot id: A0A2J8SDP5
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BTAF1
gene id: 9601:BTAF1
uniprot id: A0A2J8Y586
uniprot id: A0A6D2XZD7
names: Subcellular Location Annotation
messages: Nucleus

9601:KCNMB1
gene id: 9601:KCNMB1
uniprot id: H2PHC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9601:LOC100431491
gene id: 9601:LOC100431491
uniprot id: H2PI42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:RABAC1
gene id: 9601:RABAC1
uniprot id: A0A6D2WGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9601:FAM149A
gene id: 9601:FAM149A
uniprot id: A0A2J8T3S0
names: Caution
names: Similarity
messages: Belongs to the FAM149 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DHCR7
gene id: 9601:DHCR7
uniprot id: Q5RCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9601:LOC100458018
gene id: 9601:LOC100458018
uniprot id: H2P7Z1
uniprot id: H2P7Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9601:MRPL32
gene id: 9601:MRPL32
uniprot id: H2PMA3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9601:ASB9
gene id: 9601:ASB9
uniprot id: A0A2J8W4G0
names: Caution
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100458835
gene id: 9601:LOC100458835
uniprot id: A0A6D2XE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:VAMP8
gene id: 9601:VAMP8
uniprot id: A0A2J8RP75
uniprot id: Q5REQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Early endosome membrane
messages: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (By similarity). Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (By similarity). Interacts with PICALM (By similarity). SNARE complex formation and binding by PICALM are mutually exclusive processes for VAMP8 (By similarity). Interacts with SBF2/MTMR13 (By similarity). Interacts with RAB21 (in GTP-bound form) in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking (By similarity). Interacts with STX17; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with TRIM6 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Zymogen granule membrane

9601:LOC100432695
gene id: 9601:LOC100432695
uniprot id: A0A2J8S583
uniprot id: A0A6D2X6M7
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9601:RNF180
gene id: 9601:RNF180
uniprot id: A0A2J8VU42
uniprot id: Q5RAK3
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
messages: Endoplasmic reticulum membrane
messages: Interacts with ZIC2.
messages: Nucleus envelope
messages: The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LEMD1
gene id: 9601:LEMD1
uniprot id: A0A6D2XFM7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GSDMB
gene id: 9601:GSDMB
uniprot id: H2NU90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9601:RAI2
gene id: 9601:RAI2
uniprot id: A0A6D2Y0I0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAPK8
gene id: 9601:MAPK8
uniprot id: A0A2J8RSX3
uniprot id: A0A2J8RSY1
uniprot id: A0A2J8RT57
uniprot id: H2NAB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SOCS4
gene id: 9601:SOCS4
uniprot id: Q5RDX2
names: Domain
names: Function
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

9601:LOC100459475
gene id: 9601:LOC100459475
uniprot id: H2NU59
names: Subunit
messages: Interacts with hair keratins.

9601:AKAP13
gene id: 9601:AKAP13
uniprot id: H2NP33
names: Subcellular Location Annotation
messages: Cytoplasm

9601:FUT6
gene id: 9601:FUT6
uniprot id: A0A6D2YCA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9601:RPN2
gene id: 9601:RPN2
uniprot id: A0A8I5TLJ4
uniprot id: H2P1V0
uniprot id: Q5RBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9601:OSBPL11
gene id: 9601:OSBPL11
uniprot id: H2P9H8
names: Similarity
messages: Belongs to the OSBP family.

9601:RBKS
gene id: 9601:RBKS
uniprot id: K7EUT9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9601:CIRBP
gene id: 9601:CIRBP
uniprot id: A0A2J8R9S5
uniprot id: Q5RF83
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity).
messages: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity).
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes (By similarity).
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
messages: Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleoplasm

9601:HTR3C
gene id: 9601:HTR3C
uniprot id: H2PC54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9601:ART3
gene id: 9601:ART3
uniprot id: Q5R9E7
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9601:MED12
gene id: 9601:MED12
uniprot id: H2PVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9601:EYA4
gene id: 9601:EYA4
uniprot id: A0A2J8X970
uniprot id: A0A2J8X972
uniprot id: A0A2J8X984
uniprot id: A0A2J8X9A3
uniprot id: A0A6D2XJ42
uniprot id: H2PKD3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GRHPR
gene id: 9601:GRHPR
uniprot id: Q5REL8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9601:LRP12
gene id: 9601:LRP12
uniprot id: Q5R662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: May interact with RACK1, ZFYVE9 and NMRK2.
messages: Membrane
messages: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity).
messages: coated pit

9601:SLC25A22
gene id: 9601:SLC25A22
uniprot id: Q5RD81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity). Plays a role in the control of glucose-stimulated insulin secretion (By similarity).
messages: Mitochondrion inner membrane

9601:AK4
gene id: 9601:AK4
uniprot id: A0A2J8WPL8
uniprot id: Q5R421
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity).
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer (By similarity). Interacts with SLC25A5/ANT2 (By similarity).
messages: Monomer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NRAS
gene id: 9601:NRAS
uniprot id: Q5RD87
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7 (By similarity).
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
messages: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.

9601:PIK3CG
gene id: 9601:PIK3CG
uniprot id: H2PN59
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9601:NQO2
gene id: 9601:NQO2
uniprot id: A0A2J8WME6
uniprot id: A0A2J8WMF5
uniprot id: A0A6D2WYC6
uniprot id: Q5RBB9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
messages: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

9601:NAT2
gene id: 9601:NAT2
uniprot id: A0A8J8XLM0
uniprot id: H2PPN9
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9601:MX2
gene id: 9601:MX2
uniprot id: H2P369
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9601:MRPL33
gene id: 9601:MRPL33
uniprot id: A0A663DIT9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9601:HSDL1
gene id: 9601:HSDL1
uniprot id: A0A2J8T9N7
uniprot id: Q5R7K0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Interacts with STYXL1.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GID4
gene id: 9601:GID4
uniprot id: A0A6D2XIQ9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MBP
gene id: 9601:MBP
uniprot id: A0A803KJT2
uniprot id: Q5R618
uniprot id: Q5R7J4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MGAT5
gene id: 9601:MGAT5
uniprot id: A0A6D2VU18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9601:BMP1
gene id: 9601:BMP1
uniprot id: A0A2J8X4I9
uniprot id: A0A2J8X4R9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:RBM17
gene id: 9601:RBM17
uniprot id: A0A6D2Y3X1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9601:LOC100450365
gene id: 9601:LOC100450365
uniprot id: H2NG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SS18
gene id: 9601:SS18
uniprot id: Q5RFQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
messages: Belongs to the SS18 family.
messages: Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A.
messages: Nucleus

9601:MSTN
gene id: 9601:MSTN
uniprot id: A0A6D2XFH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9601:GSX2
gene id: 9601:GSX2
uniprot id: A0A6D2Y5E2
names: Subcellular Location Annotation
messages: Nucleus

9601:TIGD7
gene id: 9601:TIGD7
uniprot id: H2NPY4
names: Subcellular Location Annotation
messages: Nucleus

9601:PARVA
gene id: 9601:PARVA
uniprot id: A0A663DBU2
uniprot id: H2NE28
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:CFTR
gene id: 9601:CFTR
uniprot id: Q2IBE4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9601:F2
gene id: 9601:F2
uniprot id: Q5NVS1
uniprot id: Q5R537
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin; this interaction does not prevent the activation of prothrombin to thrombin.
messages: Inhibited by SERPINA5.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin (By similarity).
messages: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin (By similarity).
messages: Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9601:PROP1
gene id: 9601:PROP1
uniprot id: H2PHJ2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

9601:CASP5
gene id: 9601:CASP5
uniprot id: A0A2J8XX95
uniprot id: A0A2J8XXB0
uniprot id: A0A8I5YP34
names: Caution
names: Similarity
messages: Belongs to the peptidase C14A family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HMGB2
gene id: 9601:HMGB2
uniprot id: A0A6D2WFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9601:PTAFR
gene id: 9601:PTAFR
uniprot id: A0A6D2VYF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9601:SLC35A5
gene id: 9601:SLC35A5
uniprot id: Q5R4D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9601:STX6
gene id: 9601:STX6
uniprot id: A0A2J8V7Z3
uniprot id: Q5R6Q2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Binds EEA1. Interacts with VPS45A and GOPC. Interacts with MARCHF2; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (By similarity). Interacts with MARCHF3 (By similarity). Interacts with BLTP3B (via C-terminal coiled-coil domain). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with VPS13B (By similarity).
messages: Recycling endosome membrane
messages: SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: trans-Golgi network membrane

9601:GRN
gene id: 9601:GRN
uniprot id: Q5R5T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9601:KCTD1
gene id: 9601:KCTD1
uniprot id: A0A2J8XG11
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LTK
gene id: 9601:LTK
uniprot id: A0A2J8S5U1
uniprot id: H2NMX3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

9601:NPY5R
gene id: 9601:NPY5R
uniprot id: A0A6D2VUP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9601:KCNA2
gene id: 9601:KCNA2
uniprot id: A0A2J8UM95
uniprot id: H2N6F3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9601:APOC1
gene id: 9601:APOC1
uniprot id: A0A2J8RTR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GIF
gene id: 9601:GIF
uniprot id: H2NDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9601:POF1B
gene id: 9601:POF1B
uniprot id: Q5RBB5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with nonmuscle actin.
messages: Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development (By similarity).
messages: tight junction

9601:RAB33B
gene id: 9601:RAB33B
uniprot id: A0A2J8XP73
uniprot id: Q5R615
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Interacts with ATG16L1; the interaction is important for autophagosome formation. Interacts with ATG16L2; however interaction is approximately hundred times lower than for ATG16L1 (By similarity). Interacts with RIC1 (via C-terminus domain); the interaction is direct with a preference for RAB33B-GTP. Interacts with RGP1.
messages: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity).
messages: Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. In vitro, SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cis-Golgi network

9601:RAX2
gene id: 9601:RAX2
uniprot id: A0A6D2W4V9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CRX.
messages: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
messages: Nucleus

9601:ZC3H15
gene id: 9601:ZC3H15
uniprot id: H2P829
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9601:C12H12orf57
gene id: 9601:C12H12orf57
uniprot id: A0A2J8TBJ6
uniprot id: A0A6D2Y9G2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NSUN3
gene id: 9601:NSUN3
uniprot id: A0A663D802
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9601:PCNA
gene id: 9601:PCNA
uniprot id: A0A6D2WWJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9601:SERPINF2
gene id: 9601:SERPINF2
uniprot id: A0A2J8SNY5
uniprot id: A0A2J8SNZ3
names: Similarity
messages: Belongs to the serpin family.

9601:BIRC5
gene id: 9601:BIRC5
uniprot id: Q5RAH9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
messages: centromere
messages: kinetochore
messages: spindle

9601:LGI2
gene id: 9601:LGI2
uniprot id: A0A6D2WUH6
names: Subcellular Location Annotation
messages: Secreted

9601:TK2
gene id: 9601:TK2
uniprot id: A0A8I5TRF8
names: Similarity
messages: Belongs to the DCK/DGK family.

9601:CTSW
gene id: 9601:CTSW
uniprot id: H2NCT5
names: Similarity
messages: Belongs to the peptidase C1 family.

9601:LY75
gene id: 9601:LY75
uniprot id: H2P7M2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:LAPTM5
gene id: 9601:LAPTM5
uniprot id: A0A2J8Y7L1
uniprot id: Q5REZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Binds to ubiquitin.
messages: Lysosome membrane
messages: May have a special functional role during embryogenesis and in adult hematopoietic cells.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100459574
gene id: 9601:LOC100459574
uniprot id: A0A2J8RJU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCMH1
gene id: 9601:SCMH1
uniprot id: A0A2J8Y5X7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MED7
gene id: 9601:MED7
uniprot id: A0A2J8X6P1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC20
gene id: 9601:CDC20
uniprot id: A0A6D2Y149
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9601:LOC100435763
gene id: 9601:LOC100435763
uniprot id: K7EUY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:ZIM3
gene id: 9601:ZIM3
uniprot id: H2P0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LYPLAL1
gene id: 9601:LYPLAL1
uniprot id: Q5R8C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity).

9601:FUCA2
gene id: 9601:FUCA2
uniprot id: Q5RFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.
messages: Secreted

9601:RRP1
gene id: 9601:RRP1
uniprot id: Q5R4C8
names: Similarity
messages: Belongs to the RRP1 family.

9601:CANX
gene id: 9601:CANX
uniprot id: Q5R440
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis. The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1. Interacts with PPIB. Interacts with ZNRF4. Interacts with SMIM22 (By similarity). Interacts with TMX2 (By similarity). Interacts with TMEM35A/NACHO and CHRNA7 (By similarity). Interacts with reticulophagy regulators RETREG2 and RETREG3 (By similarity).
messages: Melanosome
messages: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
messages: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

9601:TMEM205
gene id: 9601:TMEM205
uniprot id: A0A2J8S0J7
uniprot id: Q5REM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FICD
gene id: 9601:FICD
uniprot id: A0A8I5UUD5
names: Similarity
messages: Belongs to the fic family.

9601:ARMC8
gene id: 9601:ARMC8
uniprot id: Q5R6S3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
messages: Cytoplasm
messages: Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.
messages: Nucleus

9601:SLC25A23
gene id: 9601:SLC25A23
uniprot id: H2NX83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9601:ZNF829
gene id: 9601:ZNF829
uniprot id: A0A663D881
uniprot id: H2NYK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LSM5
gene id: 9601:LSM5
uniprot id: A0A2J8UNY2
uniprot id: Q5R628
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DYDC1
gene id: 9601:DYDC1
uniprot id: A0A6D2WPG3
names: Similarity
messages: Belongs to the dpy-30 family.

9601:RPL35
gene id: 9601:RPL35
uniprot id: H2PTD7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9601:BEX2
gene id: 9601:BEX2
uniprot id: A0A2J8VB40
uniprot id: A0A6D2WY58
names: Similarity
messages: Belongs to the BEX family.

9601:FAM110A
gene id: 9601:FAM110A
uniprot id: A0A6D2WCX9
names: Similarity
messages: Belongs to the FAM110 family.

9601:TBL3
gene id: 9601:TBL3
uniprot id: H2NPS1
names: Subcellular Location Annotation
messages: nucleolus

9601:DYNC1LI2
gene id: 9601:DYNC1LI2
uniprot id: Q5RE09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).
messages: cytoskeleton

9601:SLC7A13
gene id: 9601:SLC7A13
uniprot id: H2PQQ7
names: Subcellular Location Annotation
messages: Membrane

9601:FGF6
gene id: 9601:FGF6
uniprot id: H2NG59
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9601:RAPSN
gene id: 9601:RAPSN
uniprot id: A0A2J8WET9
uniprot id: H2NDI9
names: Similarity
messages: Belongs to the RAPsyn family.

9601:RAD52
gene id: 9601:RAD52
uniprot id: A0A2J8S3N7
uniprot id: A0A6D2X7U7
names: Similarity
messages: Belongs to the RAD52 family.

9601:CLTB
gene id: 9601:CLTB
uniprot id: A0A2J8RDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9601:NDUFA9
gene id: 9601:NDUFA9
uniprot id: A0A2J8TAV1
uniprot id: P0CB81
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation. Acetylated by CLOCK in a circadian manner.
messages: Belongs to the complex I NDUFA9 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity). Interacts with CLOCK (By similarity). Interacts with RAB5IF (By similarity).
messages: Mitochondrion matrix
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:METTL21A
gene id: 9601:METTL21A
uniprot id: A0A2J8WUE8
uniprot id: Q5RE14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METTL21 family.
messages: Cytoplasm
messages: Interacts with heat shock 70 family members; at least some of these proteins are methylation substrates.
messages: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDK5
gene id: 9601:CDK5
uniprot id: H2PP22
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:TTPAL
gene id: 9601:TTPAL
uniprot id: A0A2J8XVZ0
uniprot id: Q5RFR0
names: Caution
names: Function
messages: May act as a protein that binds a hydrophobic ligand.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ING3
gene id: 9601:ING3
uniprot id: H2PNB3
uniprot id: Q5RBA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2 (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex (By similarity).
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9601:FUT8
gene id: 9601:FUT8
uniprot id: A0A6D2WSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9601:THTPA
gene id: 9601:THTPA
uniprot id: A0A6D2WRF0
uniprot id: Q5R7W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9601:HSD17B7
gene id: 9601:HSD17B7
uniprot id: H2N4Y5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9601:CD24
gene id: 9601:CD24
uniprot id: A0A2J8SG10
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLD1
gene id: 9601:PLD1
uniprot id: A0A2J8TIJ5
uniprot id: H2PC00
names: Similarity
messages: Belongs to the phospholipase D family.

9601:GALNT7
gene id: 9601:GALNT7
uniprot id: A0A2J8R9E9
uniprot id: Q5RFJ6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

9601:PEX10
gene id: 9601:PEX10
uniprot id: H2N9E8
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9601:SRFBP1
gene id: 9601:SRFBP1
uniprot id: Q5NVE2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4 (By similarity).
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
messages: perinuclear region

9601:AGPAT1
gene id: 9601:AGPAT1
uniprot id: A0A2J8R325
uniprot id: H2PIN1
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZFAND4
gene id: 9601:ZFAND4
uniprot id: A0A2J8R3Z9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SUCLG1
gene id: 9601:SUCLG1
uniprot id: Q5R584
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9601:CCR6
gene id: 9601:CCR6
uniprot id: A0A6D2X6U9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:KEF63 p12
gene id: 9601:KEF63_p12
uniprot id: A0A0X8E997
uniprot id: P92691
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9601:MTCP1
gene id: 9601:MTCP1
uniprot id: A0A6D2WNA5
names: Similarity
messages: Belongs to the TCL1 family.

9601:CES1
gene id: 9601:CES1
uniprot id: Q5R545
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9601:ATP11C
gene id: 9601:ATP11C
uniprot id: H2PWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9601:KLHL21
gene id: 9601:KLHL21
uniprot id: H2N9A2
names: Subcellular Location Annotation
messages: spindle

9601:KCNMB4
gene id: 9601:KCNMB4
uniprot id: A0A663DHQ8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MLH3
gene id: 9601:MLH3
uniprot id: Q5RED1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9601:TCEAL1
gene id: 9601:TCEAL1
uniprot id: A0A2J8VAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9601:DMRT3
gene id: 9601:DMRT3
uniprot id: H2PSA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9601:JAK2
gene id: 9601:JAK2
uniprot id: Q5RB23
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity. Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with EPOR. Interacts with LYN. Interacts with SIRPA. Interacts with SH2B1. Interacts with TEC (By similarity). Interacts with IFNGR2 (via intracellular domain) (By similarity). Interacts with LEPR (Isoform B) (By similarity). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner. Interacts with STRA6 (By similarity). Interacts with RHEX; this interaction occurs in a erythropoietin (EPO)-dependent manner (By similarity). Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (By similarity).
messages: Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.
messages: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
messages: Nucleus
messages: Regulated by autophosphorylation, can both activate or decrease activity. Heme regulates its activity by enhancing the phosphorylation on Tyr-1007 and Tyr-1008.
messages: The N-terminal domain of JAKs mediates their interaction with cytokine/interferon/growth hormone receptors. Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity).
messages: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.

9601:CRYBA2
gene id: 9601:CRYBA2
uniprot id: A0A6D2XTJ6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9601:HNRNPDL
gene id: 9601:HNRNPDL
uniprot id: A0A2J8V4C6
uniprot id: A0A6D2WKT5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:UBE4A
gene id: 9601:UBE4A
uniprot id: Q5R9G3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9601:HRASLS5
gene id: 9601:HRASLS5
uniprot id: A0A2J8TY83
uniprot id: A0A2J8TY89
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBA5
gene id: 9601:UBA5
uniprot id: Q5R8X4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer; homodimerization is required for UFM1 activation. Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Interacts (via UIS motif) with GABARAPL2 and, with lower affinity, with GABARAP and GABARAPL1. Interacts (via C-terminus) with UFC1.
messages: Nucleus
messages: The UFM1-interacting sequence (UIS) motif mediates interaction with both UFM1 and LC3/GABARAP proteins (GABARAP, GABARAPL1 and GABARAPL2).

9601:TOMM40L
gene id: 9601:TOMM40L
uniprot id: A0A6D2W9Y8
uniprot id: Q5R9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:CHST11
gene id: 9601:CHST11
uniprot id: A0A2J8XM27
uniprot id: A0A6D2YCK6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC16A9
gene id: 9601:SLC16A9
uniprot id: Q5R5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

9601:ZNF483
gene id: 9601:ZNF483
uniprot id: H2PT15
names: Subcellular Location Annotation
messages: Nucleus

9601:PI4K2A
gene id: 9601:PI4K2A
uniprot id: H2NB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9601:ATP5MC1
gene id: 9601:ATP5MC1
uniprot id: A0A6D2W6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9601:INTS10
gene id: 9601:INTS10
uniprot id: H2PPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9601:GAB1
gene id: 9601:GAB1
uniprot id: H2PEE0
names: Similarity
messages: Belongs to the GAB family.

9601:STMP1
gene id: 9601:STMP1
uniprot id: A0A2J8V3N1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPHOSPH8
gene id: 9601:MPHOSPH8
uniprot id: H2NJB7
uniprot id: Q5RD82
names: Subcellular Location Annotation
messages: Nucleus

9601:PRPS1L1
gene id: 9601:PRPS1L1
uniprot id: A0A6D2W3Z5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM214
gene id: 9601:TMEM214
uniprot id: A0A6D2Y1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:MYOZ3
gene id: 9601:MYOZ3
uniprot id: A0A6D2X6X0
names: Similarity
messages: Belongs to the myozenin family.

9601:MESD
gene id: 9601:MESD
uniprot id: A0A6D2X835
uniprot id: Q5R6F1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MESD family.
messages: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
messages: Endoplasmic reticulum
messages: Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression.
messages: The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
messages: The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.

9601:LOC100436988
gene id: 9601:LOC100436988
uniprot id: H2PD08
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9601:LOC103891240
gene id: 9601:LOC103891240
uniprot id: A0A8I5U3R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:MTERF3
gene id: 9601:MTERF3
uniprot id: H2PQV0
names: Similarity
messages: Belongs to the mTERF family.

9601:ADAMTSL2
gene id: 9601:ADAMTSL2
uniprot id: A0A6D2WR84
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYL12A
gene id: 9601:MYL12A
uniprot id: A0A2J8XGQ0
uniprot id: Q5RC34
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
messages: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This chain binds calcium.

9601:STAT1
gene id: 9601:STAT1
uniprot id: Q5R5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9601:COPS5
gene id: 9601:COPS5
uniprot id: H2PQH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9601:PUS7
gene id: 9601:PUS7
uniprot id: A0A803KHY2
uniprot id: Q5R4M5
names: Caution
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MME
gene id: 9601:MME
uniprot id: Q5RE69
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
messages: Myristoylation is a determinant of membrane targeting.
messages: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

9601:S100A9
gene id: 9601:S100A9
uniprot id: H2N5P8
names: Similarity
messages: Belongs to the S-100 family.

9601:CREB3L4
gene id: 9601:CREB3L4
uniprot id: A0A2J8VFS9
uniprot id: H2N5M6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHF10
gene id: 9601:PHF10
uniprot id: H2PKX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9601:GLP2R
gene id: 9601:GLP2R
uniprot id: H2NSQ5
names: Subcellular Location Annotation
messages: Membrane

9601:C5H5orf22
gene id: 9601:C5H5orf22
uniprot id: Q5R5W9
names: Similarity
messages: Belongs to the UPF0489 family.

9601:BEST4
gene id: 9601:BEST4
uniprot id: H2N7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9601:UPB1
gene id: 9601:UPB1
uniprot id: Q5RBM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.
messages: Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide.
messages: Cytoplasm
messages: Homodimer, homotetramer, homooctamer; can also form higher homooligomers.

9601:RNF40
gene id: 9601:RNF40
uniprot id: Q5RAU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC.
messages: Nucleus

9601:ACSL1
gene id: 9601:ACSL1
uniprot id: Q5RAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9601:FUBP3
gene id: 9601:FUBP3
uniprot id: A0A2J8UJH5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HNMT
gene id: 9601:HNMT
uniprot id: Q5R7C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
messages: Cytoplasm
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9601:ZNF184
gene id: 9601:ZNF184
uniprot id: A0A6D2W1L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:UPF3A
gene id: 9601:UPF3A
uniprot id: A0A2J8X7Q9
uniprot id: H2NKF2
names: Similarity
messages: Belongs to the RENT3 family.

9601:HNRNPD
gene id: 9601:HNRNPD
uniprot id: A0A2J8V4A8
uniprot id: A0A2J8V4B3
uniprot id: H2PDR7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:HS3ST1
gene id: 9601:HS3ST1
uniprot id: H2PCX6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9601:VMO1
gene id: 9601:VMO1
uniprot id: A0A2J8SPM3
uniprot id: A0A2J8SPP5
uniprot id: A0A2J8SPQ1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100439336
gene id: 9601:LOC100439336
uniprot id: A0A2J8S4Y0
uniprot id: Q5R893
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (By similarity). H2BS6ADPr promotes recruitment of CHD1L (By similarity). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (By similarity). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid (By similarity).
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VSIG1
gene id: 9601:VSIG1
uniprot id: A0A2J8VAN4
uniprot id: H2PWF8
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100453318
gene id: 9601:LOC100453318
uniprot id: H2PI57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9601:PSMC3
gene id: 9601:PSMC3
uniprot id: A0A6D2WIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9601:PLCZ1
gene id: 9601:PLCZ1
uniprot id: H2NGR4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9601:NXT1
gene id: 9601:NXT1
uniprot id: H2P170
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9601:FOXP1
gene id: 9601:FOXP1
uniprot id: A0A2J8SWD6
uniprot id: A0A2J8SWE1
uniprot id: A0A2J8SWE9
uniprot id: A0A2J8SWF8
uniprot id: A0A6D2X438
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDADC1
gene id: 9601:CDADC1
uniprot id: Q5RAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis.
messages: Cytoplasm
messages: Nucleus

9601:PCTP
gene id: 9601:PCTP
uniprot id: A0A6D2XWX3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SERPING1
gene id: 9601:SERPING1
uniprot id: H2NDF8
names: Similarity
messages: Belongs to the serpin family.

9601:RPS18
gene id: 9601:RPS18
uniprot id: A0A6D2WQE8
uniprot id: H2PXT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PNMA2
gene id: 9601:PNMA2
uniprot id: Q5R486
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9601:FAM212A
gene id: 9601:FAM212A
uniprot id: A0A8I5T6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9601:SH3BGRL2
gene id: 9601:SH3BGRL2
uniprot id: Q5R892
names: Similarity
messages: Belongs to the SH3BGR family.

9601:CXCR2
gene id: 9601:CXCR2
uniprot id: H2P8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ENGASE
gene id: 9601:ENGASE
uniprot id: H2NUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9601:CMTM2
gene id: 9601:CMTM2
uniprot id: A0A2J8VUA4
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDI1
gene id: 9601:DDI1
uniprot id: H2NF42
names: Similarity
messages: Belongs to the DDI1 family.

9601:ANXA7
gene id: 9601:ANXA7
uniprot id: H2NAJ8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9601:PFN2
gene id: 9601:PFN2
uniprot id: Q5R4E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (By similarity).
messages: cytoskeleton

9601:LOC100460119
gene id: 9601:LOC100460119
uniprot id: H2PCU9
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9601:SLC4A1
gene id: 9601:SLC4A1
uniprot id: A0A2J8UYF9
uniprot id: Q5RBP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ELF1
gene id: 9601:ELF1
uniprot id: H2NJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:MRPS10
gene id: 9601:MRPS10
uniprot id: Q5RFM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9601:GLI3
gene id: 9601:GLI3
uniprot id: H2PMA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

9601:ZPLD1
gene id: 9601:ZPLD1
uniprot id: A0A2J8T945
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MB
gene id: 9601:MB
uniprot id: A0A2J8UVT2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9601:TMEM59
gene id: 9601:TMEM59
uniprot id: Q5R800
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
messages: Belongs to the TMEM59 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with ATG16L1 (via WD repeats).
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.
messages: The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.

9601:LOC100444335
gene id: 9601:LOC100444335
uniprot id: A0A8I5TVU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:F11R
gene id: 9601:F11R
uniprot id: H2N531
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9601:C11H11orf96
gene id: 9601:C11H11orf96
uniprot id: A0A2J8WFL1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IQCF6
gene id: 9601:IQCF6
uniprot id: A0A2J8THA2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RNASE7
gene id: 9601:RNASE7
uniprot id: A0A6D2X7E3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9601:RNF4
gene id: 9601:RNF4
uniprot id: A0A2J8SRU1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VAMP1
gene id: 9601:VAMP1
uniprot id: A0A2J8TB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9601:SLC2A7
gene id: 9601:SLC2A7
uniprot id: H2N979
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9601:FGF14
gene id: 9601:FGF14
uniprot id: A0A2J8X8N0
uniprot id: H2NK86
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9601:PITX2
gene id: 9601:PITX2
uniprot id: A0A2J8XQ65
uniprot id: A0A2J8XQG2
uniprot id: A0A6D2X8B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9601:STAT2
gene id: 9601:STAT2
uniprot id: A0A2J8UHP1
uniprot id: A0A2J8UHQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COQ5
gene id: 9601:COQ5
uniprot id: Q5RBK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9601:GPSM3
gene id: 9601:GPSM3
uniprot id: A0A6D2WHJ0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASB8
gene id: 9601:ASB8
uniprot id: A0A2J8WD41
uniprot id: Q5R6D7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: Cytoplasm
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC4A8
gene id: 9601:SLC4A8
uniprot id: H2NHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9601:TRAM1L1
gene id: 9601:TRAM1L1
uniprot id: H2PE65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9601:ABCC12
gene id: 9601:ABCC12
uniprot id: A0A2J8VY20
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100435064
gene id: 9601:LOC100435064
uniprot id: H2NIP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:FMOD
gene id: 9601:FMOD
uniprot id: H2N436
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9601:COASY
gene id: 9601:COASY
uniprot id: A0A2J8RF19
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAT1A
gene id: 9601:MAT1A
uniprot id: H2NAF6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9601:ACO2
gene id: 9601:ACO2
uniprot id: A0A663D959
uniprot id: H2P4J6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VSX2
gene id: 9601:VSX2
uniprot id: H2NLS1
names: Subcellular Location Annotation
messages: Nucleus

9601:NDUFB8
gene id: 9601:NDUFB8
uniprot id: P0CB85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:BRAF
gene id: 9601:BRAF
uniprot id: H2PNQ1
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9601:ASB13
gene id: 9601:ASB13
uniprot id: H2N9N8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9601:OCLN
gene id: 9601:OCLN
uniprot id: A0A2J8VTN7
uniprot id: A0A6D2XLF8
uniprot id: Q5RFS5
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Dephosphorylated by PTPRJ.
messages: Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2.
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: tight junction

9601:DMBX1
gene id: 9601:DMBX1
uniprot id: A0A2J8SLI2
uniprot id: H2N7I9
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EIF3E
gene id: 9601:EIF3E
uniprot id: Q5R8K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: PML body

9601:SIK2
gene id: 9601:SIK2
uniprot id: Q5REX1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
messages: Activated by phosphorylation on Thr-175.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with and phosphorylates TORC2/CRTC2.
messages: Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated at Thr-484 in response to insulin in adipocytes.
messages: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (By similarity). Also plays a role in thymic T-cell development (By similarity).

9601:PPARD
gene id: 9601:PPARD
uniprot id: H2PIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9601:BCKDK
gene id: 9601:BCKDK
uniprot id: A0A6D2X4S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9601:SNX20
gene id: 9601:SNX20
uniprot id: A0A2J8VY89
uniprot id: A0A2J8VYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9601:TMEM130
gene id: 9601:TMEM130
uniprot id: Q5R6F5
names: Subcellular Location Annotation
messages: Golgi apparatus membrane

9601:FABP9
gene id: 9601:FABP9
uniprot id: H2PQN3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9601:PDGFRA
gene id: 9601:PDGFRA
uniprot id: H2PDE4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9601:LRP10
gene id: 9601:LRP10
uniprot id: Q5RDI3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:ATP6V1C1
gene id: 9601:ATP6V1C1
uniprot id: A0A2J8UFM2
uniprot id: Q5RDQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9601:SLC22A8
gene id: 9601:SLC22A8
uniprot id: A0A2J8TY68
uniprot id: A0A6D2W6W8
uniprot id: Q5R9C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain. Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic…
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDH3
gene id: 9601:CDH3
uniprot id: A0A2J8VVD5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9601:TCEANC
gene id: 9601:TCEANC
uniprot id: A0A663DFC9
uniprot id: H2PUX9
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IL7
gene id: 9601:IL7
uniprot id: A0A2J8V9Y1
uniprot id: A0A2J8V9Y3
uniprot id: A0A2J8VA03
uniprot id: A0A6D2XIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9601:EMC6
gene id: 9601:EMC6
uniprot id: A0A6D2XBL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:UBE2G2
gene id: 9601:UBE2G2
uniprot id: A0A2J8RSB2
uniprot id: Q5RF84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Endoplasmic reticulum
messages: Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.
messages: Lipid droplet
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC25A48
gene id: 9601:SLC25A48
uniprot id: A0A2J8VQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:TEX13A
gene id: 9601:TEX13A
uniprot id: A0A6D2X6T5
names: Similarity
messages: Belongs to the TEX13 family.

9601:MAP3K7
gene id: 9601:MAP3K7
uniprot id: A0A2J8VRX4
uniprot id: Q5RFL3
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Lys-48'-linked polyubiquitination at Lys-72 is induced by TNFalpha, and leads to proteasomal degradation. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH. 'Lys-63'-linked polyubiquitination at Lys-158 by TRIM8 does not lead to proteasomal degradation but contributes to autophosphorylation and activation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains.
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation (By similarity).
messages: Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads to inactivation (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Can form homodimer. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3. Identified in the TRIKA2 complex composed of MAP3K7/TAK1, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L and PPM1B/PP2CB. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with DYNC2I2 (via WD domains). Interacts with CYLD and RBCK1. Interacts with TGFBR1; induces MAP3K7/TAK1 activation by TRAF6. Interacts with MAPK8IP1 and SMAD6. Interacts with isoform 1 of VRK2. Interacts with DAB2; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation. Interacts with TRIM5. Part of a complex containing ITCH, NDFIP1 and MAP3K7. Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation. Interacts with PLEKHM1 (via N- and C-terminus). Found in a complex with SH3RF1, RAC2, MAP2K7/MKK7, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2. Interacts with SASH1 (By similarity). Interacts with RIPK1 (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (By similarity). Promotes TRIM5 capsid-specific restriction activity (By similarity). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACSF2
gene id: 9601:ACSF2
uniprot id: Q5R9G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Mitochondrion

9601:SCNN1G
gene id: 9601:SCNN1G
uniprot id: H2NQE2
names: Subcellular Location Annotation
messages: Membrane

9601:IL17RE
gene id: 9601:IL17RE
uniprot id: A0A2J8WDP1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SFTPC
gene id: 9601:SFTPC
uniprot id: A0A2J8X4H2
uniprot id: A0A2J8X4H6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: surface film

9601:NOP14
gene id: 9601:NOP14
uniprot id: A0A6D2Y023
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9601:IMPG1
gene id: 9601:IMPG1
uniprot id: H2PJM2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9601:RIC3
gene id: 9601:RIC3
uniprot id: A0A2J8SVB8
uniprot id: A0A2J8SVD5
uniprot id: A0A663DAQ9
uniprot id: H2NE64
names: Caution
names: Similarity
messages: Belongs to the ric-3 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAS2R5
gene id: 9601:TAS2R5
uniprot id: H2PP96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:CEP63
gene id: 9601:CEP63
uniprot id: A0A2J8S2B2
uniprot id: Q5NVN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP63 family.
messages: Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes. Interacts with CDK2, CDK5RAP2, WDR62, CEP90, KdIAA0753/moonraker and CCDC14. CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles. Interacts with CCDC57; the interaction is required for their location to proximal end of centrioles (By similarity).
messages: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centriolar satellite
messages: centriole
messages: centrosome

9601:CROT
gene id: 9601:CROT
uniprot id: A0A6D2X6P5
uniprot id: H2PN01
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9601:KCNJ11
gene id: 9601:KCNJ11
uniprot id: A0A2J8UQD2
uniprot id: H2NE01
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PNPLA5
gene id: 9601:PNPLA5
uniprot id: A0A6D2XGP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:APOA4
gene id: 9601:APOA4
uniprot id: A0A663D7S7
names: Caution
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AAMDC
gene id: 9601:AAMDC
uniprot id: A0A6D2WKE6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCAMP3
gene id: 9601:SCAMP3
uniprot id: H2N5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9601:C1D
gene id: 9601:C1D
uniprot id: A0A2J8XC10
uniprot id: Q5RBU4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2. Interacts with EXOSC10. Forms a heterotrimeric complex with EXOSC10 and MPHOSPH6 in vitro. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3 (By similarity).
messages: Nucleus
messages: Phosphorylated by PRKDC.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA. Forms a multi-subunit complex with MPHOSPH6 and EXOSC10 and this complex along with MTR4 is required for the 3'-5' end processing of the 5.8S rRNA. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:TMEM63A
gene id: 9601:TMEM63A
uniprot id: Q5R826
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity).
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Cell membrane
messages: Lysosome membrane

9601:SGK2
gene id: 9601:SGK2
uniprot id: Q5RDZ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:RHBDD2
gene id: 9601:RHBDD2
uniprot id: A0A663DGV0
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ISM2
gene id: 9601:ISM2
uniprot id: A0A6D2XPY0
names: Caution
names: Similarity
messages: Belongs to the isthmin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HCRTR1
gene id: 9601:HCRTR1
uniprot id: A0A2J8Y7G3
uniprot id: A0A6D2YAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:IRAK1BP1
gene id: 9601:IRAK1BP1
uniprot id: A0A6D2XVC5
uniprot id: H2PJM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CHMP1B
gene id: 9601:CHMP1B
uniprot id: A0A2J8RFU9
names: Caution
names: Similarity
messages: Belongs to the SNF7 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AP1G1
gene id: 9601:AP1G1
uniprot id: Q5R5M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3) (By similarity). Interacts (via GAE domain) with RABEP1 (By similarity). Interacts with EPS15 (By similarity). Interacts with SYNRG/gamma-synergin (By similarity). Interacts (via GAE domain) with AP1AR (via coiled-coil domain) (By similarity). Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (By similarity). Interacts (via GAE domain) with AFTPH/aftiphilin; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (By similarity).
messages: Belongs to the adaptor complexes large subunit family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity).
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: clathrin-coated vesicle membrane
messages: perinuclear region

9601:MLF2
gene id: 9601:MLF2
uniprot id: A0A6D2WPF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9601:XYLB
gene id: 9601:XYLB
uniprot id: Q5R830
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FGGY kinase family.
messages: Monomer.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9601:NR3C2
gene id: 9601:NR3C2
uniprot id: Q5R9F2
names: Subcellular Location Annotation
messages: Nucleus

9601:TMEM53
gene id: 9601:TMEM53
uniprot id: H2N7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9601:EFNA5
gene id: 9601:EFNA5
uniprot id: A0A6D2Y360
uniprot id: H2PG80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:CDC14A
gene id: 9601:CDC14A
uniprot id: A0A2J8VCL4
names: Caution
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STK17B
gene id: 9601:STK17B
uniprot id: A0A6D2X6F5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:KRT36
gene id: 9601:KRT36
uniprot id: A0A6D2X3I8
uniprot id: H2NU33
names: Caution
names: Similarity
messages: Belongs to the intermediate filament family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAOK2
gene id: 9601:TAOK2
uniprot id: A0A663DEZ6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAR2
gene id: 9601:FAR2
uniprot id: A0A2J8WBY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9601:SLC35B4
gene id: 9601:SLC35B4
uniprot id: A0A2J8V3V0
uniprot id: Q5R8M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NDP
gene id: 9601:NDP
uniprot id: A0A6D2WSD0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:LOC100436684
gene id: 9601:LOC100436684
uniprot id: H2NED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ST7
gene id: 9601:ST7
uniprot id: Q5R9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9601:GUCY2C
gene id: 9601:GUCY2C
uniprot id: H2NGP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9601:LCE3C
gene id: 9601:LCE3C
uniprot id: H2N5S2
names: Similarity
messages: Belongs to the LCE family.

9601:C1H1orf210
gene id: 9601:C1H1orf210
uniprot id: A0A6D2XIH3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GRIN2B
gene id: 9601:GRIN2B
uniprot id: H2NGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9601:LOC100433145
gene id: 9601:LOC100433145
uniprot id: A0A6D2WFK4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9601:MMGT1
gene id: 9601:MMGT1
uniprot id: Q5RA70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity).

9601:NDNF
gene id: 9601:NDNF
uniprot id: H2PE78
names: Subcellular Location Annotation
messages: Secreted

9601:PPP2R2B
gene id: 9601:PPP2R2B
uniprot id: A0A2J8VNP3
uniprot id: Q5R4A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: Membrane
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: cytoskeleton

9601:METTL8
gene id: 9601:METTL8
uniprot id: A0A6D2W5F7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9601:CCDC190
gene id: 9601:CCDC190
uniprot id: A0A2J8SLA1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COQ10B
gene id: 9601:COQ10B
uniprot id: A0A2J8WVI2
uniprot id: Q5RD79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FIBIN
gene id: 9601:FIBIN
uniprot id: Q5RA12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9601:ASB17
gene id: 9601:ASB17
uniprot id: H2N706
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9601:TXNDC5
gene id: 9601:TXNDC5
uniprot id: H2PHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9601:RHCG
gene id: 9601:RHCG
uniprot id: H2NP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9601:LOC100432101
gene id: 9601:LOC100432101
uniprot id: H2PDA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9601:RPL36
gene id: 9601:RPL36
uniprot id: A0A2J8SC52
uniprot id: Q5RAZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:MOGAT2
gene id: 9601:MOGAT2
uniprot id: H2NEP8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:KIAA0319L
gene id: 9601:KIAA0319L
uniprot id: A0A2J8Y6W7
uniprot id: Q5RFR6
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic granule membrane
messages: Golgi apparatus membrane
messages: Interacts with RTN4R.
messages: N-glycosylated.
messages: Possible role in axon guidance through interaction with RTN4R.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: trans-Golgi network membrane

9601:GPRASP2
gene id: 9601:GPRASP2
uniprot id: A0A2J8VB53
uniprot id: Q5R7U0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPRASP family.
messages: Interacts with cytoplasmic tails of a variety of G protein-coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.
messages: May play a role in regulation of a variety of G-protein coupled receptors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ABCC2
gene id: 9601:ABCC2
uniprot id: H2NB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9601:FOXJ2
gene id: 9601:FOXJ2
uniprot id: H2NGE0
names: Subcellular Location Annotation
messages: Nucleus

9601:AKR1A1
gene id: 9601:AKR1A1
uniprot id: Q5R5D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (By similarity).
messages: Monomer.
messages: cytosol

9601:TBPL1
gene id: 9601:TBPL1
uniprot id: Q5R7U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.
messages: Cytoplasm
messages: Nucleus
messages: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity).

9601:TUBA1B
gene id: 9601:TUBA1B
uniprot id: K7EW05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9601:CBX5
gene id: 9601:CBX5
uniprot id: A0A6D2X312
names: Subcellular Location Annotation
messages: Nucleus

9601:USP46
gene id: 9601:USP46
uniprot id: A0A2J8SGI5
uniprot id: Q5RBQ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
messages: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).
messages: Interacts with WDR48. Interacts with WDR20.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPH
gene id: 9601:CENPH
uniprot id: A0A663D5X7
uniprot id: H2PFR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: kinetochore

9601:VAC14
gene id: 9601:VAC14
uniprot id: H2NRF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9601:MTERF4
gene id: 9601:MTERF4
uniprot id: A0A663DHV1
uniprot id: H2P963
names: Similarity
messages: Belongs to the mTERF family.

9601:LOC100432687
gene id: 9601:LOC100432687
uniprot id: A0A8I5YRG6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:COPZ1
gene id: 9601:COPZ1
uniprot id: A0A2J8UID3
uniprot id: Q5R5F2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9601:TNP1
gene id: 9601:TNP1
uniprot id: H2P8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9601:RTN1
gene id: 9601:RTN1
uniprot id: A0A2J8WLF0
uniprot id: H2NLE3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SNRNP200
gene id: 9601:SNRNP200
uniprot id: Q5RCJ7
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9601:ZNF230
gene id: 9601:ZNF230
uniprot id: Q5R6K2
names: Subcellular Location Annotation
messages: Nucleus

9601:FAM103A1
gene id: 9601:FAM103A1
uniprot id: A0A2J8SGC7
uniprot id: Q5R9Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAM family.
messages: Interacts with RNMT; this interaction enhances mRNA binding and cap methyltransferase activity.
messages: Nucleus
messages: Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:COPS7A
gene id: 9601:COPS7A
uniprot id: A0A2J8TBE0
uniprot id: Q5R762
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interacts directly with ID3.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CK2 and PKD kinases.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GEM
gene id: 9601:GEM
uniprot id: A0A6D2X1L0
uniprot id: Q5R541
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. RGK family.
messages: Cell membrane
messages: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity (By similarity).
messages: Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1 (By similarity).
messages: Phosphorylated on tyrosine residues.

9601:PAX5
gene id: 9601:PAX5
uniprot id: A0A2J8T047
uniprot id: A0A2J8T050
uniprot id: A0A2J8T056
uniprot id: A0A2J8T059
uniprot id: A0A2J8T060
uniprot id: A0A2J8T081
uniprot id: A0A2J8T0B8
uniprot id: H2PRQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASB1
gene id: 9601:ASB1
uniprot id: H2P935
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9601:ATAT1
gene id: 9601:ATAT1
uniprot id: Q5R999
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9601:C19H19orf70
gene id: 9601:C19H19orf70
uniprot id: H2NX55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9601:P2RY1
gene id: 9601:P2RY1
uniprot id: H2PBS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ELAC1
gene id: 9601:ELAC1
uniprot id: A0A8I5U4M9
names: Subunit
messages: Homodimer.

9601:SS18L2
gene id: 9601:SS18L2
uniprot id: A0A6D2WUW1
names: Similarity
messages: Belongs to the SS18 family.

9601:HSPH1
gene id: 9601:HSPH1
uniprot id: Q5R606
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with HSPA8/HSC70. Interacts with HSPA1A (via NBD) and HSPA1B (via NBD).
messages: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

9601:TMEM41A
gene id: 9601:TMEM41A
uniprot id: H2PC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9601:NCL
gene id: 9601:NCL
uniprot id: A0A2J8TQC3
uniprot id: Q5RF26
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with AICDA. Interacts with APTX. Interacts with C1QBP. Interacts with ERBB4. Interacts (via C-terminus) with FMR1 isoform 6 (via N-terminus). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1. Interacts with NSUN2. Interacts with NVL. Interacts (via N-terminus domain) with SETX. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT. Interacts with WDR46. Interacts with ZFP36. Interacts with LRRC34. Interacts with RRP1B. Interacts with HNRNPU; this interaction occurs during mitosis. Interacts with RIOK1; RIOK1 recruits NCL to the PRMT5 for symmetrically methylation (By similarity). Interacts with ZBTB7B (By similarity). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (By similarity). Interacts with HDGF (By similarity). Interacts with ALKBH2.
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
messages: Symmetrically methylated by PRMT5 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:POLR2I
gene id: 9601:POLR2I
uniprot id: H2NYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9601:C1H1orf162
gene id: 9601:C1H1orf162
uniprot id: A0A2J8UM62
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC42BPB
gene id: 9601:CDC42BPB
uniprot id: H2NMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9601:NR6A1
gene id: 9601:NR6A1
uniprot id: A0A2J8SFP1
uniprot id: H2PTD1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM126B
gene id: 9601:TMEM126B
uniprot id: A0A663DCS6
uniprot id: H2NEU8
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RUNDC3B
gene id: 9601:RUNDC3B
uniprot id: Q5NVC2
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

9601:SMIM19
gene id: 9601:SMIM19
uniprot id: A0A2J8TNK8
uniprot id: Q5RBD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHF6
gene id: 9601:PHF6
uniprot id: A0A2J8WWX1
uniprot id: A0A2J8WWY3
uniprot id: Q5R5Z2
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UBTF. Interacts with the NuRD complex component RBBP4 (via the nucleolar localization motif), the interaction mediates transcriptional repression activity (By similarity).
messages: Nucleus
messages: The PHD-type zinc finger 1 mediates both nucleolar localization and interaction with UBTF.
messages: The ePHD2 domain folds as an integrated structural module comprizing the C2HC pre-PHD-type 2 zinc finger and the PHD-type 2 zinc finger. It mediates non-specific binding to dsDNA, but doesn't bind histones in contrast to many PHD-type zinc fingers.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
messages: kinetochore
messages: nucleolus

9601:ACBD4
gene id: 9601:ACBD4
uniprot id: A0A2J8UYT9
uniprot id: A0A6D2VX40
uniprot id: Q5R7P6
names: Caution
names: Function
messages: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPBP1L1
gene id: 9601:GPBP1L1
uniprot id: A0A2J8SLP7
uniprot id: Q5R9C3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus
messages: Possible transcription factor.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GTSF1
gene id: 9601:GTSF1
uniprot id: A0A6D2X7E7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BTN2A1
gene id: 9601:BTN2A1
uniprot id: Q5R7W8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
messages: Membrane
messages: N-glycosylated.

9601:MAGEB16
gene id: 9601:MAGEB16
uniprot id: A0A6D2WKK4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SMO
gene id: 9601:SMO
uniprot id: H2PNH3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:ADPRM
gene id: 9601:ADPRM
uniprot id: H2NSR5
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9601:PRKAR1A
gene id: 9601:PRKAR1A
uniprot id: A0A2J8V090
uniprot id: Q5REL1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
messages: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interacts with CBFA2T3. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PEX3
gene id: 9601:PEX3
uniprot id: H2PKH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9601:AK1
gene id: 9601:AK1
uniprot id: A0A6D2Y6B2
uniprot id: Q5REN6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACY1
gene id: 9601:ACY1
uniprot id: H2PAL1
uniprot id: Q5RFB0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SPHK1 (By similarity).

9601:LOC100456233
gene id: 9601:LOC100456233
uniprot id: H2PEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9601:KCNC2
gene id: 9601:KCNC2
uniprot id: A0A2J8W1D6
uniprot id: A0A2J8W1D7
uniprot id: A0A2J8W1E2
uniprot id: A0A2J8W1E5
uniprot id: A0A2J8W1F1
uniprot id: A0A2J8W1M0
names: Subcellular Location Annotation
messages: Membrane

9601:GLO1
gene id: 9601:GLO1
uniprot id: A0A663DFR8
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9601:ZC3HC1
gene id: 9601:ZC3HC1
uniprot id: A0A2J8U4E8
uniprot id: Q5R8V9
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity).
messages: Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1 (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dependent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry (By similarity).
messages: The F-box-like region is required for the interaction with SKP1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNAP23
gene id: 9601:SNAP23
uniprot id: Q5R5T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9601:C19H19orf54
gene id: 9601:C19H19orf54
uniprot id: A0A663D9G2
names: Similarity
messages: Belongs to the UPF0692 family.

9601:SMAD2
gene id: 9601:SMAD2
uniprot id: Q5R7C0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity.
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1 (By similarity).
messages: In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity).
messages: Monomer; in the absence of TGF-beta (By similarity). Heterodimer; in the presence of TGF-beta (By similarity). Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta (By similarity). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD (By similarity). Interacts with TAZ/WWRT1 (By similarity). Interacts with FOXH1 (By similarity). Interacts with SNW1 (By similarity). Interacts with CREB-binding protein (CBP) and EP300 (By similarity). Interacts with SNON (By similarity). Interacts with ALK4/ACVR1B (By similarity). Interacts with SKOR1 (By similarity). Interacts with SKOR2 (By similarity). Interacts with PRDM16 (By similarity). Interacts (via MH2 domain) with LEMD3 (By similarity). Interacts with RBPMS (By similarity). Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (By similarity). Interacts with PDPK1 (via PH domain) (By similarity). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (By similarity). Interacts with USP15 (By similarity). Interacts with PPP5C (By similarity). Interacts with LDLRAD4 (via the SMAD interaction motif) (By similarity). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif) (By similarity). Interacts with ZFHX3 (By similarity). Interacts with ZNF451 (By similarity). Interacts with SMURF2 when phosphorylated on Ser-465/467 (By similarity). Interacts with PPM1A (By similarity). Interacts with TGF-beta (By similarity). Interacts with TGFBR1 (By similarity). Interacts with TGIF (By similarity). Interacts with SMAD3 and TRIM33 (By similarity). Int…
messages: Nucleus
messages: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

9601:FH
gene id: 9601:FH
uniprot id: Q5RBC0
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9601:ATP5MC3
gene id: 9601:ATP5MC3
uniprot id: A0A2J8VR74
uniprot id: Q5RFL2
names: Caution
names: Disease Annotation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with TMEM70 and TMEM242 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.
messages: This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).
messages: Trimethylated by ATPSCKMT at Lys-110. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.

9601:DNMBP
gene id: 9601:DNMBP
uniprot id: H2NBA0
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

9601:BCDIN3D
gene id: 9601:BCDIN3D
uniprot id: Q5RFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with DICER1; the interaction may be mediated by RNA.
messages: O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.

9601:NDRG4
gene id: 9601:NDRG4
uniprot id: A0A2J8VZL4
uniprot id: K7ET54
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:MCEE
gene id: 9601:MCEE
uniprot id: H2P5W2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9601:PMPCA
gene id: 9601:PMPCA
uniprot id: Q5R513
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9601:TJP2
gene id: 9601:TJP2
uniprot id: H2PSB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9601:GRB7
gene id: 9601:GRB7
uniprot id: A0A2J8WA03
uniprot id: A0A6D2Y2R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9601:FAM89B
gene id: 9601:FAM89B
uniprot id: A0A2J8TZF8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTCD2
gene id: 9601:PTCD2
uniprot id: Q5R503
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
messages: Mitochondrion

9601:ZNF181
gene id: 9601:ZNF181
uniprot id: H2NYD9
uniprot id: Q5REF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:POLR3G
gene id: 9601:POLR3G
uniprot id: A0A6D2XPF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9601:DDA1
gene id: 9601:DDA1
uniprot id: A0A2J8T6G8
uniprot id: Q5RD86
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDA1 family.
messages: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1. Part of the DDD core complex containing DET1, DDA1 and DDB1; the DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.
messages: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNIP1
gene id: 9601:KCNIP1
uniprot id: A0A2J8X7B8
uniprot id: A0A663DGQ3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2D4
gene id: 9601:UBE2D4
uniprot id: A0A2J8STA2
uniprot id: A0A2J8STA9
uniprot id: A0A8I5TLE0
names: Caution
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPR4
gene id: 9601:GPR4
uniprot id: H2NZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TRIP10
gene id: 9601:TRIP10
uniprot id: Q5RCJ1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, PDE6G, SRC and WAS/WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT (By similarity). Interacts specifically with GTP-bound CDC42 and RHOQ. Interacts with DNM2 and WASL (By similarity).
messages: Lysosome
messages: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. May be required for the lysosomal retention of FASLG/FASL (By similarity).
messages: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
messages: Tyrosine phosphorylated. Also phosphorylated by PKA (By similarity).
messages: cell cortex
messages: cytoskeleton
messages: phagocytic cup

9601:C11H11orf97
gene id: 9601:C11H11orf97
uniprot id: A0A2J8XWL2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TLX3
gene id: 9601:TLX3
uniprot id: H2PHC5
names: Subcellular Location Annotation
messages: Nucleus

9601:COLGALT2
gene id: 9601:COLGALT2
uniprot id: H2N4E7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9601:IL15
gene id: 9601:IL15
uniprot id: A0A6D2VSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9601:ENPEP
gene id: 9601:ENPEP
uniprot id: Q5R7D5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9601:LOC100448469
gene id: 9601:LOC100448469
uniprot id: H2NEF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ORAI2
gene id: 9601:ORAI2
uniprot id: A0A2J8XU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9601:LOC100454113
gene id: 9601:LOC100454113
uniprot id: H2N571
names: Subcellular Location Annotation
messages: Membrane

9601:POU4F2
gene id: 9601:POU4F2
uniprot id: H2PEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9601:NEXMIF
gene id: 9601:NEXMIF
uniprot id: A0A2J8UT36
names: Subcellular Location Annotation
messages: Nucleus

9601:NADK
gene id: 9601:NADK
uniprot id: A0A6D2XQY9
names: Similarity
messages: Belongs to the NAD kinase family.

9601:PPA2
gene id: 9601:PPA2
uniprot id: H2PE15
names: Similarity
messages: Belongs to the PPase family.

9601:LOC100439875
gene id: 9601:LOC100439875
uniprot id: A0A8I5TMV2
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9601:DHPS
gene id: 9601:DHPS
uniprot id: H2NXP1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9601:NMI
gene id: 9601:NMI
uniprot id: H2P7J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9601:CDCA7
gene id: 9601:CDCA7
uniprot id: A0A2J8VR06
uniprot id: H2P7V0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:PTGES
gene id: 9601:PTGES
uniprot id: A0A6D2XAX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9601:BOC
gene id: 9601:BOC
uniprot id: H2P9Q2
names: Subcellular Location Annotation
messages: Cell membrane

9601:FAM173B
gene id: 9601:FAM173B
uniprot id: A0A2J8SHH4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IMPAD1
gene id: 9601:IMPAD1
uniprot id: H2PQC8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9601:SLC22A12
gene id: 9601:SLC22A12
uniprot id: A0A2J8TYQ8
uniprot id: A0A2J8TYR1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPEG1
gene id: 9601:MPEG1
uniprot id: Q5RBP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Monoubiquitinated in response to bacterial infection; ubiquitination is required for vesicular localization and antibacterial activity and can be blocked by bacterial cell cycle inhibiting factor (cif) (By similarity).
messages: Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).

9601:RPS15
gene id: 9601:RPS15
uniprot id: A0A2J8R9L5
uniprot id: A0A2J8R9M1
uniprot id: Q5RDI7
names: Caution
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TUBB
gene id: 9601:TUBB
uniprot id: A0A2J8SJF9
uniprot id: Q5R943
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Heterodimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with PIFO. Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity). Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9601:ELF4
gene id: 9601:ELF4
uniprot id: A0A2J8WWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:TRIT1
gene id: 9601:TRIT1
uniprot id: H2N7V3
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9601:KCNH7
gene id: 9601:KCNH7
uniprot id: A0A2J8T515
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ELOF1
gene id: 9601:ELOF1
uniprot id: A0A2J8RYK4
uniprot id: A0A6D2VXC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9601:ADIPOR1
gene id: 9601:ADIPOR1
uniprot id: H2N448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9601:IL18
gene id: 9601:IL18
uniprot id: H2NFA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9601:MRPL42
gene id: 9601:MRPL42
uniprot id: A0A2J8XN65
uniprot id: A0A6D2X8P6
uniprot id: Q5RDW7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUS1
gene id: 9601:NUS1
uniprot id: H2PXM0
names: Similarity
messages: Belongs to the UPP synthase family.

9601:PGS1
gene id: 9601:PGS1
uniprot id: Q5R8K7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium and magnesium and inhibited by other bivalent cations.
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9601:INHA
gene id: 9601:INHA
uniprot id: H2P8Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9601:UNC5CL
gene id: 9601:UNC5CL
uniprot id: A0A6D2XWG3
names: Similarity
messages: Belongs to the unc-5 family.

9601:TM4SF5
gene id: 9601:TM4SF5
uniprot id: H2NSC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9601:PSAP
gene id: 9601:PSAP
uniprot id: Q5R406
uniprot id: Q5R4U7
names: Subcellular Location Annotation
messages: Secreted

9601:MCM6
gene id: 9601:MCM6
uniprot id: H2P7G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9601:ATE1
gene id: 9601:ATE1
uniprot id: Q5RB46
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9601:GRIK1
gene id: 9601:GRIK1
uniprot id: A0A2J8UKP9
uniprot id: A0A2J8UKR3
uniprot id: H2P2V7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAAR5
gene id: 9601:TAAR5
uniprot id: F7VJP9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:MED19
gene id: 9601:MED19
uniprot id: A0A663DEH3
uniprot id: H2NDF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SUMO2
gene id: 9601:SUMO2
uniprot id: A0A6D2XTP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9601:PPP1R10
gene id: 9601:PPP1R10
uniprot id: H2PIF1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9601:RFTN1
gene id: 9601:RFTN1
uniprot id: H2PBD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9601:DMGDH
gene id: 9601:DMGDH
uniprot id: H2PFY5
names: Similarity
messages: Belongs to the GcvT family.

9601:DMAP1
gene id: 9601:DMAP1
uniprot id: A0A6D2Y2N3
names: Subcellular Location Annotation
messages: Nucleus

9601:NPY
gene id: 9601:NPY
uniprot id: A0A6D2WRP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9601:RMDN3
gene id: 9601:RMDN3
uniprot id: A0A2J8S613
uniprot id: Q5R6Z1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMDN family.
messages: Cytoplasm
messages: Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB. Interacts (FFAT motif) with MOSPD2 (via MSP domain).
messages: Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).
messages: Mitochondrion outer membrane
messages: Nucleus
messages: The FFAT motif is required for interaction with MOSPD2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The transmembrane region is required for mitochondrial localization.
messages: spindle
messages: spindle pole

9601:ATG16L1
gene id: 9601:ATG16L1
uniprot id: A0A2J8TQ01
uniprot id: Q5RAC9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ATG16 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Homodimer (By similarity). Homooligomer (By similarity). Heterooligomer with ATG16L2 (By similarity). Interacts with WIPI1. Interacts with WIPI2. Interacts with RB1CC1; the interaction is required for ULK1 complex-dependent autophagy. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B. Interacts (via WD repeats) with TMEM59; the interaction mediates unconventional autophagic activity of TMEM59. Interacts with TLR2 and NOD2. Interacts (via WD repeats) with MEFV. Interacts with PPP1CA; the interaction dephosphorylates ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex. Interacts (via N-terminal) with CLTC. Interacts with NOD2. Interacts with TUFM. Interacts with TRIM16 (By similarity). Interacts (via WD repeats) with SPATA33 (By similarity).
messages: Lysosome membrane
messages: Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.
messages: Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling. During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8. Thereby, controls the elongation of the nascent autophagosomal membrane. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (By similarity). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a role in regulating morphology and function of Paneth cell (By similarity).
messages: Preautophagosomal structure membrane
messages: Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.
messages: The WD repeats are required for non-canonical autophagy but not for canonical autophagy.

9601:RUNX2
gene id: 9601:RUNX2
uniprot id: A0A2J8Y4Y0
uniprot id: A0A2J8Y4Y2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GON4L
gene id: 9601:GON4L
uniprot id: A0A2J8VGL8
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADH5
gene id: 9601:ADH5
uniprot id: H2PDY2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9601:ACAA1
gene id: 9601:ACAA1
uniprot id: A0A6D2WYZ1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9601:IL24
gene id: 9601:IL24
uniprot id: A0A2J8V6S8
uniprot id: H2N3X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPP4C
gene id: 9601:PPP4C
uniprot id: A0A2J8TK62
uniprot id: Q5R6K8
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
messages: Nucleus
messages: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 and GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome

9601:LOC100435638
gene id: 9601:LOC100435638
uniprot id: A0A663DCM1
uniprot id: H2PXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9601:SYT10
gene id: 9601:SYT10
uniprot id: A0A2J8WC96
uniprot id: Q5RCK6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
messages: Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.
messages: The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
messages: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: secretory vesicle membrane

9601:HBB
gene id: 9601:HBB
uniprot id: H2NEE2
names: Similarity
messages: Belongs to the globin family.

9601:MYH1
gene id: 9601:MYH1
uniprot id: A0A6D2WG23
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9601:SHOC2
gene id: 9601:SHOC2
uniprot id: Q5RAV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHOC2 family.
messages: Cytoplasm
messages: Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS. Interacts with LZTR1.
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9601:GSG1L
gene id: 9601:GSG1L
uniprot id: A0A2J8TJH8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF14
gene id: 9601:ZNF14
uniprot id: Q5R9F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:KPNA4
gene id: 9601:KPNA4
uniprot id: H2PBW1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9601:SNTB2
gene id: 9601:SNTB2
uniprot id: H2NRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9601:SLC16A2
gene id: 9601:SLC16A2
uniprot id: H2PW21
names: Subcellular Location Annotation
messages: Membrane

9601:LRTOMT
gene id: 9601:LRTOMT
uniprot id: A0A2J8V211
uniprot id: A0A2J8V212
uniprot id: A0A6D2WNJ0
uniprot id: K7EUU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALMS1
gene id: 9601:ALMS1
uniprot id: H2P5U1
names: Subcellular Location Annotation
messages: centrosome

9601:TBCE
gene id: 9601:TBCE
uniprot id: A0A2J8UDZ9
uniprot id: Q5RBD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCE family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers (By similarity). Interacts with TBCD (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
messages: cytoskeleton

9601:ZDHHC24
gene id: 9601:ZDHHC24
uniprot id: A0A2J8U022
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9601:SUSD6
gene id: 9601:SUSD6
uniprot id: A0A663DB24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:LPCAT3
gene id: 9601:LPCAT3
uniprot id: H2NGB5
names: Subcellular Location Annotation
messages: Membrane

9601:ZSCAN4
gene id: 9601:ZSCAN4
uniprot id: A0A6D2WVU6
names: Subcellular Location Annotation
messages: Nucleus

9601:IPPK
gene id: 9601:IPPK
uniprot id: H2PSP7
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9601:LOC100435206
gene id: 9601:LOC100435206
uniprot id: A0A2J8S583
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9601:UNC93A
gene id: 9601:UNC93A
uniprot id: H2PKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9601:SLC25A21
gene id: 9601:SLC25A21
uniprot id: A0A2J8V9D7
uniprot id: A0A2J8V9D9
uniprot id: Q5RFB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.

9601:IKZF5
gene id: 9601:IKZF5
uniprot id: Q5R9W9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Pegasus' was the winged horse in Greek mythology.
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: C-terminal zinc fingers mediate homodimerization.
messages: Nucleus
messages: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF4 (By similarity).
messages: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
messages: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity). Involved in megakaryocyte differentiation (By similarity).

9601:GLRX2
gene id: 9601:GLRX2
uniprot id: A0A2J8UY09
uniprot id: Q5RC53
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutaredoxin family.
messages: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity).
messages: Mitochondrion
messages: Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster (By similarity).
messages: The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CYB561
gene id: 9601:CYB561
uniprot id: A0A2J8UZD0
uniprot id: Q5RCZ2
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.
messages: chromaffin granule membrane

9601:CA5B
gene id: 9601:CA5B
uniprot id: A0A6D2WW23
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9601:NIP7
gene id: 9601:NIP7
uniprot id: A0A2J8VVJ9
uniprot id: Q5R9J1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:RAB32
gene id: 9601:RAB32
uniprot id: A0A663DAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9601:TMEM233
gene id: 9601:TMEM233
uniprot id: A0A2J8XKA1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9601:ZNF500
gene id: 9601:ZNF500
uniprot id: A0A663DDM1
uniprot id: H2NQ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:NOL10
gene id: 9601:NOL10
uniprot id: H2P6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9601:KEF63 p02
gene id: 9601:KEF63_p02
uniprot id: A0A110AYI4
uniprot id: P92700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9601:TNNT2
gene id: 9601:TNNT2
uniprot id: A0A2J8UXL7
uniprot id: H2N479
names: Caution
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9601:LOC100451648
gene id: 9601:LOC100451648
uniprot id: A0A8I5TGE8
uniprot id: H2N4B2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MINDY2
gene id: 9601:MINDY2
uniprot id: A0A2J8VCB0
uniprot id: H2NND2
names: Caution
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100436515
gene id: 9601:LOC100436515
uniprot id: H2PXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9601:OGFOD1
gene id: 9601:OGFOD1
uniprot id: Q5R4R3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPA1 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.

9601:RIOK3
gene id: 9601:RIOK3
uniprot id: Q5RCL8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9601:LOC100456773
gene id: 9601:LOC100456773
uniprot id: A0A2J8VFH7
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9601:TMEM39A
gene id: 9601:TMEM39A
uniprot id: H2P9N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9601:SYNCRIP
gene id: 9601:SYNCRIP
uniprot id: A0A2J8V2R6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDB1
gene id: 9601:DDB1
uniprot id: Q5R649
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated, promoting interaction with CUL4 (CUL4A or CUL4B) and subsequent formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Deacetylation by SIRT7 impairs the interaction with CUL4 (CUL4A or CUL4B) and formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes.
messages: Belongs to the DDB1 family.
messages: Component of the UV-DDB complex which includes DDB1 and DDB2; the heterodimer dimerizes to give rise to a heterotetramer when bound to damaged DNA. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1. DDB1 may recruit specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Interacts with AMBRA1, ATG16L1, BTRC, CRBN, DCAF1, DCAF4, DCAF5, DCAF6, DCAF7, DCAF8, DCAF9, DCAF10, DCAF11, DCAF12, DCAF15, DCAF16, DCAF17, DDA1, DET1, DTL, ERCC8, FBXW5, FBXW8, GRWD1, KATNB1, NLE1, NUP43, PAFAH1B1, PHIP, PWP1, RBBP4, RBBP5, RBBP7, COP1, SNRNP40, DCAF1, WDR5, WDR5B, WDR12, WDR26, WDR39, WDR42, WDR53, WDR59, WDR61, WSB1, WSB2, LRWD1 and WDTC1. DCX complexes may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. Interacts with NF2, TSC1 and TSC2. Interacts with AGO1 and AGO2. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts directly with DYRK2. DCX(DTL) complex interacts with FBXO11; does not ubiquitinate and degradate FBXO11. Interacts with TRPC4AP (By similarity). Interacts with CRY1 and CRY2 (By similarity). The DDB1-CUL4A complex interacts with CRY1 (By similarity). May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by ABL1.
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity).
messages: The core of the protein consists of three WD40 beta-propeller domains.
messages: Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis.

9601:HAPLN1
gene id: 9601:HAPLN1
uniprot id: H2PG15
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:NIPA1
gene id: 9601:NIPA1
uniprot id: H2NMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9601:LOC100442237
gene id: 9601:LOC100442237
uniprot id: H2NMR4
names: Similarity
messages: Belongs to the actin family.

9601:HGD
gene id: 9601:HGD
uniprot id: Q5RF05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the homogentisate dioxygenase family.
messages: Catalyzes the conversion of homogentisate to maleylacetoacetate.
messages: Homohexamer arranged as a dimer of trimers.

9601:CPA3
gene id: 9601:CPA3
uniprot id: H2PBP8
names: Similarity
messages: Belongs to the peptidase M14 family.

9601:DEFB113
gene id: 9601:DEFB113
uniprot id: H2PJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9601:MAPK6
gene id: 9601:MAPK6
uniprot id: A0A2J8VBS9
uniprot id: H2NN91
uniprot id: Q5R7U1
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation at Ser-189.
messages: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4 (By similarity).
messages: In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
messages: Nucleus
messages: Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitination at Met-1 leads to degradation by the proteasome pathway.

9601:MAOA
gene id: 9601:MAOA
uniprot id: A0A2J8WIP2
uniprot id: Q5RE60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100460861
gene id: 9601:LOC100460861
uniprot id: H2P2Y0
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9601:ZC2HC1A
gene id: 9601:ZC2HC1A
uniprot id: Q5REC0
names: Similarity
messages: Belongs to the ZC2HC1 family.

9601:PTN
gene id: 9601:PTN
uniprot id: A0A2J8V3K4
uniprot id: K7EV95
names: Caution
names: Similarity
messages: Belongs to the pleiotrophin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRMT10C
gene id: 9601:TRMT10C
uniprot id: H2P9V6
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9601:BARHL2
gene id: 9601:BARHL2
uniprot id: H2N6T3
names: Subcellular Location Annotation
messages: Nucleus

9601:GLB1L3
gene id: 9601:GLB1L3
uniprot id: H2NFX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9601:BTK
gene id: 9601:BTK
uniprot id: A0A2J8U632
uniprot id: A0A6D2WDR2
uniprot id: H2PW99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRPH2
gene id: 9601:PRPH2
uniprot id: H2PJ26
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9601:SLC38A10
gene id: 9601:SLC38A10
uniprot id: Q5RC98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane
messages: Putative sodium-dependent amino acid/proton antiporter.

9601:NUF2
gene id: 9601:NUF2
uniprot id: A0A6D2X8Y1
names: Similarity
messages: Belongs to the NUF2 family.

9601:SUSD4
gene id: 9601:SUSD4
uniprot id: Q5R8M2
names: Function
names: Subcellular Location Annotation
messages: Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
messages: Membrane

9601:PDCL2
gene id: 9601:PDCL2
uniprot id: H2PDD7
names: Similarity
messages: Belongs to the phosducin family.

9601:ATP5F1A
gene id: 9601:ATP5F1A
uniprot id: A0A2J8XF30
uniprot id: Q5R546
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation.
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity). Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (By similarity). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (By similarity). Interacts with S100A1; this interaction increases F1-ATPase activity (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).
messages: Mitochondrion inner membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps bacteria scavenge iron ions from the environment. As a consequence, the mammalian siderocalin LCN2 plays an important role in defense against bacterial infections by sequestering iron bound to microbial siderophores. LCN2 can also bind iron bound to endogenous or nutrient-derived iron chelators and plays an important role in cellular iron homeostasis. Enterobactin produced by non-pathogenic E.coli strains can facilitate mitochondrial iron assimilation, suggesting that iron bound to siderophores from non-pathogenic bacteria may contribute to iron absorption by the host.

9601:SNRPG
gene id: 9601:SNRPG
uniprot id: A0A663D7R6
uniprot id: H2P5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9601:CHCHD7
gene id: 9601:CHCHD7
uniprot id: A0A2J8UNB3
uniprot id: A0A2J8UNC5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GFRA2
gene id: 9601:GFRA2
uniprot id: Q5RE29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9601:GADD45G
gene id: 9601:GADD45G
uniprot id: A0A663DIN7
names: Similarity
messages: Belongs to the GADD45 family.

9601:PDGFB
gene id: 9601:PDGFB
uniprot id: H2P4F5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9601:TAF7
gene id: 9601:TAF7
uniprot id: A0A2J8VP37
uniprot id: Q5R7L9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF7 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF1; the interaction is direct. Interacts with TAF1, TAF5, TAF11, TAF12, and TAF13, but not with TAF10 or TBP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CIITA and TAF1 and inhibits their acetyltransferase activity, and behaving as a repressor of CIITA- and TAF1-regulated promoters.
messages: Nucleus
messages: Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EDIL3
gene id: 9601:EDIL3
uniprot id: Q5R7K9
names: Function
names: Subcellular Location Annotation
messages: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development (By similarity).
messages: Secreted

9601:CDK20
gene id: 9601:CDK20
uniprot id: A0A2J8WNW1
uniprot id: A0A2J8WNX1
uniprot id: Q5R7I7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Monomer. Interacts with TBC1D32 and MAK.
messages: Nucleus
messages: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cilium

9601:LAMP2
gene id: 9601:LAMP2
uniprot id: A0A2J8WWG6
uniprot id: A0A2J8WWG7
uniprot id: H2PWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9601:FTL
gene id: 9601:FTL
uniprot id: A0A2J8U7U0
uniprot id: Q5R538
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NDUFA7
gene id: 9601:NDUFA7
uniprot id: A0A2J8RD51
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MDH1
gene id: 9601:MDH1
uniprot id: H2P624
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9601:PLA2G5
gene id: 9601:PLA2G5
uniprot id: H2N8S0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9601:SRPK1
gene id: 9601:SRPK1
uniprot id: Q5RD27
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation on Ser-51 and Ser-555.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Chromosome
messages: Cytoplasm
messages: Microsome
messages: Monomer. Found in a multisubunit complex containing seven proteins, named toposome, which separates entangled circular chromatin DNA during chromosome segregation. Interacts with HHV-1 ICP27 protein. Interacts with DNAJC8 and AHSA1/AHA1 and this mediates formation of a complex with the Hsp70 /Hsp90 machinery. Binds to IGF2BP1, SYNCRIP, HNRNPA2B1 and HNRNPC. Interacts with SAFB/SAFB1 and SAFB2 which inhibits its activity (By similarity).
messages: Nucleus matrix
messages: Nucleus speckle
messages: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Phosphorylates SFRS2, ZRSR2, LBR and PRM1. Phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without aff…
messages: nucleoplasm

9601:NXT2
gene id: 9601:NXT2
uniprot id: A0A2J8VAL0
uniprot id: A0A663D9X5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF131
gene id: 9601:ZNF131
uniprot id: Q5RAU9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity).
messages: Monosumoylated at Lys-567 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination (By similarity).
messages: Nucleus
messages: Ubiquitinated.

9601:PIP4K2C
gene id: 9601:PIP4K2C
uniprot id: Q5R488
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity.
messages: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
messages: Phosphorylated, phosphorylation is induced by EGF.

9601:FGR
gene id: 9601:FGR
uniprot id: A0A6D2W2I8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9601:RASGEF1B
gene id: 9601:RASGEF1B
uniprot id: A0A2J8UUI3
uniprot id: Q5RC04
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Early endosome
messages: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
messages: Interacts with CCDC124 during cytokinesis. Interacts with Ras family proteins (By similarity).
messages: Late endosome
messages: Midbody
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATAD1
gene id: 9601:ATAD1
uniprot id: Q5REE7
names: Similarity
messages: Belongs to the AAA ATPase family.

9601:ZNF557
gene id: 9601:ZNF557
uniprot id: A0A2J8R6M8
uniprot id: H2NX98
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CTSK
gene id: 9601:CTSK
uniprot id: A0A6D2W3T2
uniprot id: H2N5Y2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9601:EFCAB14
gene id: 9601:EFCAB14
uniprot id: A0A663DAN8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZFYVE1
gene id: 9601:ZFYVE1
uniprot id: Q5RFL4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Golgi stack
messages: Interacts with RAB18 (in GTP-bound form) (By similarity). Interacts with BSCL2 in a RAB18-dependent manner (By similarity). Interacts with ZW10 (By similarity).
messages: Lipid droplet
messages: Mitochondrion
messages: Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Regulates the morphology, size and distribution of LDs (By similarity). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity).
messages: Preautophagosomal structure

9601:DDR1
gene id: 9601:DDR1
uniprot id: H2PIG5
names: Subcellular Location Annotation
messages: Membrane

9601:GRAMD1C
gene id: 9601:GRAMD1C
uniprot id: Q5RC33
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).
messages: Endoplasmic reticulum membrane
messages: GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM.
messages: VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.

9601:FAM219B
gene id: 9601:FAM219B
uniprot id: A0A6D2Y2N1
names: Similarity
messages: Belongs to the FAM219 family.

9601:BPGM
gene id: 9601:BPGM
uniprot id: A0A6D2Y7V5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9601:IWS1
gene id: 9601:IWS1
uniprot id: A0A6D2WXI4
uniprot id: H2P7A2
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPS24
gene id: 9601:RPS24
uniprot id: A0A2J8U543
uniprot id: A0A6D2Y8N7
uniprot id: Q5RAQ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9601:LOC100458290
gene id: 9601:LOC100458290
uniprot id: H2PIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9601:UCHL1
gene id: 9601:UCHL1
uniprot id: A0A663DBC4
uniprot id: H2PD65
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SDR16C5
gene id: 9601:SDR16C5
uniprot id: A0A663DIF6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:MAB21L2
gene id: 9601:MAB21L2
uniprot id: H2PEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9601:GPR152
gene id: 9601:GPR152
uniprot id: H2NCN1
names: Subcellular Location Annotation
messages: Cell membrane

9601:CAPZB
gene id: 9601:CAPZB
uniprot id: A0A2J8T2D9
uniprot id: Q5R507
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with ACTG1. Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: sarcomere

9601:PDZD3
gene id: 9601:PDZD3
uniprot id: A0A2J8X0K7
uniprot id: A0A6D2W4M7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PXN
gene id: 9601:PXN
uniprot id: Q5R7I1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paxillin family.
messages: Binds to vinculin and to the SH3 domain of SRC. Interacts with GIT1, NUDT16L1/SDOS, PARVA, PARVB, SORBS1 and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2. Interacts with RNF5 and PDCD10 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2 (By similarity). Interacts with PTK6 (By similarity). Interacts with CD36. Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (By similarity). Interacts with PXN; this complex stabilizes actin dynamics (By similarity).
messages: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
messages: Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation (By similarity). Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion (By similarity). Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (By similarity).
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9601:AURKC
gene id: 9601:AURKC
uniprot id: A0A6D2XXS2
uniprot id: H2P0C0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9601:LRRC41
gene id: 9601:LRRC41
uniprot id: Q5R9H2
names: Caution
names: Domain
names: Function
names: Subunit
messages: It is uncertain whether Met-1 or Met-23 is the initiator.
messages: Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, ELOB and ELOC (By similarity).
messages: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

9601:SAR1A
gene id: 9601:SAR1A
uniprot id: A0A2J8RN93
uniprot id: Q5R548
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with B3GAT1.
messages: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF655
gene id: 9601:ZNF655
uniprot id: H2PLK0
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100437553
gene id: 9601:LOC100437553
uniprot id: H2NA67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:RCHY1
gene id: 9601:RCHY1
uniprot id: A0A2J8UU12
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLCO1C1
gene id: 9601:SLCO1C1
uniprot id: A0A2J8T1T5
uniprot id: H2NGS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNHIT6
gene id: 9601:ZNHIT6
uniprot id: Q5RF97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCD1 family.
messages: Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9 (By similarity). Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP (By similarity).
messages: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

9601:FAM181A
gene id: 9601:FAM181A
uniprot id: A0A2J8TLR3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM120A
gene id: 9601:TMEM120A
uniprot id: A0A6D2XH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9601:C11H11orf49
gene id: 9601:C11H11orf49
uniprot id: A0A2J8WF37
uniprot id: A0A8I5YKZ6
uniprot id: Q5RC14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSTPP1 family.
messages: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin.
messages: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centriolar satellite
messages: cytoskeleton

9601:ECM1
gene id: 9601:ECM1
uniprot id: A0A663DGZ4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSAPL1
gene id: 9601:PSAPL1
uniprot id: H2PCT7
names: Function
names: Subcellular Location Annotation
messages: May activate the lysosomal degradation of sphingolipids.
messages: Secreted

9601:NDFIP1
gene id: 9601:NDFIP1
uniprot id: H2PGX1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9601:CCR3
gene id: 9601:CCR3
uniprot id: A0A6D2WBY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CLNS1A
gene id: 9601:CLNS1A
uniprot id: Q5R719
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least PRMT5/SKB1, WDR77/MEP50 and CLNS1A/pICln. May mediate SNRPD1 and SNRPD3 methylation. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with LSM10 and LSM11 (By similarity).
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: cytosol

9601:APOOL
gene id: 9601:APOOL
uniprot id: Q5NVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with MICOS10/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9601:ACVRL1
gene id: 9601:ACVRL1
uniprot id: Q5RAN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well (By similarity).

9601:ZUP1
gene id: 9601:ZUP1
uniprot id: H2PK57
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9601:CHGA
gene id: 9601:CHGA
uniprot id: H2NM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9601:DHX8
gene id: 9601:DHX8
uniprot id: A0A6D2WFG6
uniprot id: H2NTW6
uniprot id: Q5R4K2
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:REN
gene id: 9601:REN
uniprot id: H2N424
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9601:NAGK
gene id: 9601:NAGK
uniprot id: A0A6D2WP97
uniprot id: Q5REK5
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9601:EGR3
gene id: 9601:EGR3
uniprot id: H2PPS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9601:RPL15
gene id: 9601:RPL15
uniprot id: A0A2J8WZ55
uniprot id: Q5NVE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRF1
gene id: 9601:PRF1
uniprot id: A0A6D2Y2V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9601:RBM48
gene id: 9601:RBM48
uniprot id: A0A2J8WJY7
uniprot id: Q5R4U2
names: Caution
names: Similarity
messages: Belongs to the RBM48 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF354C
gene id: 9601:ZNF354C
uniprot id: H2PHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LIN7C
gene id: 9601:LIN7C
uniprot id: A0A2J8S4J3
uniprot id: Q5RAA5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Forms a complex with CASK and APBA1 or CASKIN1. Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). Interacts with MAPK12 (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells (By similarity).
messages: Postsynaptic density membrane
messages: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
messages: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
messages: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: tight junction

9601:VTI1A
gene id: 9601:VTI1A
uniprot id: A0A6D2XPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9601:VPS26B
gene id: 9601:VPS26B
uniprot id: A0A6D2XLZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9601:PRPF40B
gene id: 9601:PRPF40B
uniprot id: A0A663DGS6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC42EP2
gene id: 9601:CDC42EP2
uniprot id: A0A2J8TZA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9601:HOXD1
gene id: 9601:HOXD1
uniprot id: H2P7Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9601:LOC100459239
gene id: 9601:LOC100459239
uniprot id: A0A7R8GUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9601:BAZ2A
gene id: 9601:BAZ2A
uniprot id: A0A6D2XTK9
uniprot id: H2NHQ8
names: Similarity
messages: Belongs to the WAL family.

9601:TMEM155
gene id: 9601:TMEM155
uniprot id: Q5R4Y3
names: Subcellular Location Annotation
messages: Membrane

9601:ALG13
gene id: 9601:ALG13
uniprot id: A0A2J8VAF8
uniprot id: A0A2J8VAF9
names: Caution
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEC61B
gene id: 9601:SEC61B
uniprot id: A0A2J8WSF1
uniprot id: Q5RB31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (By similarity). Interacts with TRAM1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100436899
gene id: 9601:LOC100436899
uniprot id: H2PK81
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9601:LOC100441531
gene id: 9601:LOC100441531
uniprot id: H2PDG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9601:ZMYND15
gene id: 9601:ZMYND15
uniprot id: A0A2J8SPM4
uniprot id: A0A2J8SPN2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSME4
gene id: 9601:PSME4
uniprot id: H2P679
names: Similarity
messages: Belongs to the BLM10 family.

9601:DTX4
gene id: 9601:DTX4
uniprot id: H2NDC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9601:BEX1
gene id: 9601:BEX1
uniprot id: H2PWB8
names: Similarity
messages: Belongs to the BEX family.

9601:CARTPT
gene id: 9601:CARTPT
uniprot id: H2PFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9601:MRPL53
gene id: 9601:MRPL53
uniprot id: Q5RB44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9601:MMAA
gene id: 9601:MMAA
uniprot id: H2PEF5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9601:NRBP1
gene id: 9601:NRBP1
uniprot id: A0A2J8VN53
uniprot id: Q5RBH9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Endomembrane system
messages: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).
messages: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cell cortex
messages: lamellipodium

9601:COMTD1
gene id: 9601:COMTD1
uniprot id: H2NAH7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9601:DPYSL2
gene id: 9601:DPYSL2
uniprot id: A0A2J8X504
uniprot id: Q5R9Y6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1 (By similarity).
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Membrane
messages: Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity).
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity).
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: cytosol

9601:UBE2L3
gene id: 9601:UBE2L3
uniprot id: Q5R5I4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cytoplasm
messages: In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.
messages: Interacts with PRKN; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with NDFIP1 (via N-terminus); the interaction mediates recruitment of UBE2L3 to ITCH and causes MAP3K7 ubiquitination.
messages: Nucleus
messages: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
messages: Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro.

9601:PIGV
gene id: 9601:PIGV
uniprot id: A0A6D2XG30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9601:RAB11A
gene id: 9601:RAB11A
uniprot id: A0A2J8T808
uniprot id: Q5R9M7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with RAB11FIP5 (By similarity). Interacts with STXBP6 (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5. Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with DEF6 (By similarity).
messages: Recycling endosome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity).
messages: phagosome

9601:SRPRA
gene id: 9601:SRPRA
uniprot id: Q5RAC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9601:LOC103891438
gene id: 9601:LOC103891438
uniprot id: H2N355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:HSP90AB1
gene id: 9601:HSP90AB1
uniprot id: Q5R710
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylatio…
messages: Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interac…
messages: Nucleus
messages: Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
messages: S-nitrosylated; negatively regulates the ATPase activity.
messages: Secreted
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).

9601:TSN
gene id: 9601:TSN
uniprot id: A0A663DHI8
uniprot id: Q5R7P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: Cytoplasm
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (By similarity).
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand (By similarity).
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9601:AGXT2
gene id: 9601:AGXT2
uniprot id: Q5RFA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).
messages: Homotetramer.
messages: Mitochondrion

9601:FEZ1
gene id: 9601:FEZ1
uniprot id: H2NFS3
names: Similarity
messages: Belongs to the zygin family.

9601:LOC103890842
gene id: 9601:LOC103890842
uniprot id: H2PI88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:RFNG
gene id: 9601:RFNG
uniprot id: A0A6D2XSV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:PRR23A
gene id: 9601:PRR23A
uniprot id: H2PBK7
names: Similarity
messages: Belongs to the PRR23 family.

9601:TAZ
gene id: 9601:TAZ
uniprot id: A0A663D9B0
uniprot id: H2PX87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CBX1
gene id: 9601:CBX1
uniprot id: A0A6D2X7K2
names: Subcellular Location Annotation
messages: Nucleus

9601:CLCN5
gene id: 9601:CLCN5
uniprot id: A0A2J8S2N5
uniprot id: A0A6D2X846
uniprot id: Q5RBK4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.

9601:TGM7
gene id: 9601:TGM7
uniprot id: H2NN09
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:LEP
gene id: 9601:LEP
uniprot id: H2PNF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9601:SETD2
gene id: 9601:SETD2
uniprot id: H2PAW9
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9601:PAX8
gene id: 9601:PAX8
uniprot id: A0A2J8SH26
uniprot id: A0A2J8SH35
uniprot id: A0A2J8SH54
uniprot id: A0A6D2XFI6
uniprot id: Q5R594
uniprot id: Q5R9M8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with WWTR1.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).

9601:MFAP1
gene id: 9601:MFAP1
uniprot id: H2NN30
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9601:LOC100431578
gene id: 9601:LOC100431578
uniprot id: A0A8I5YKV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9601:GSTM3
gene id: 9601:GSTM3
uniprot id: A0A2J8UMF4
uniprot id: A0A6D2Y5Z8
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9601:CLDN3
gene id: 9601:CLDN3
uniprot id: H2PLX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:RFLNA
gene id: 9601:RFLNA
uniprot id: A0A2J8XJA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9601:LOC103893093
gene id: 9601:LOC103893093
uniprot id: A0A6D2X3L6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MOG
gene id: 9601:MOG
uniprot id: A0A2J8SJR0
uniprot id: A0A2J8SJR5
uniprot id: A0A2J8SJS1
uniprot id: A0A2J8SJS3
uniprot id: A0A2J8SJS4
uniprot id: A0A2J8SJT5
uniprot id: A0A2J8SJV8
uniprot id: Q5R960
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SSR1
gene id: 9601:SSR1
uniprot id: A0A2J8WMP9
uniprot id: A0A2J8WMQ9
uniprot id: Q5R4X4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (By similarity).
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Phosphorylated in its cytoplasmic tail.
messages: Seems to bind calcium.
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins (By similarity).
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100432410
gene id: 9601:LOC100432410
uniprot id: H2NJ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:PFN3
gene id: 9601:PFN3
uniprot id: H2PHI2
names: Similarity
messages: Belongs to the profilin family.

9601:PTPA
gene id: 9601:PTPA
uniprot id: Q5RDS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:PDE7A
gene id: 9601:PDE7A
uniprot id: Q5R5B5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9601:LAMB1
gene id: 9601:LAMB1
uniprot id: H2PN73
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9601:NDUFV3
gene id: 9601:NDUFV3
uniprot id: A0A2J8UB21
uniprot id: H2P3A0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SCP2
gene id: 9601:SCP2
uniprot id: Q5R8I4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9601:CD63
gene id: 9601:CD63
uniprot id: A0A6D2XU24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9601:ORC5
gene id: 9601:ORC5
uniprot id: H2PN49
names: Subcellular Location Annotation
messages: Nucleus

9601:E2F7
gene id: 9601:E2F7
uniprot id: H2NI47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9601:ZFR
gene id: 9601:ZFR
uniprot id: Q5REX3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Found in a cytoplasmic RNP complex with STAU2. Interacts with STAU2. Does not interact with STAU1 (By similarity).
messages: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).
messages: Nucleus

9601:UCN2
gene id: 9601:UCN2
uniprot id: H2PAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9601:TMTC2
gene id: 9601:TMTC2
uniprot id: A0A663DHP6
uniprot id: H2NI67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9601:LOC103888873
gene id: 9601:LOC103888873
uniprot id: H2P2W9
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9601:SF3B3
gene id: 9601:SF3B3
uniprot id: Q5RBI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSE1 family.
messages: Identified in the spliceosome A complex; remains associated with the spliceosome throughout the splicing process. Component of the spliceosome B complex. Identified in the spliceosome C complex. Identified in the spliceosome E complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interaction between SF3B3 and SF3B1 is tighter than the interaction between SF3B3 and SF3B2. Within the SF3B complex interacts directly with SF3B1 (via HEAT domain), SF3B5 and PHF5A. The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H. Interacts with TAF3.
messages: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
messages: Nucleus
messages: The core of the protein consists of three beta-propeller domains.

9601:GDI2
gene id: 9601:GDI2
uniprot id: A0A2J8VJY4
uniprot id: Q5RCE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
messages: Interacts with RHOH. Interacts with the GDP-bound forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent. Interacts with RAB8A (GDP-bound inactive form); prevents RAB8A activation. Interacts with DZIP1; negatively regulates the interaction of GDI2 with GDP-bound RAB8A.
messages: Membrane
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9601:IP6K3
gene id: 9601:IP6K3
uniprot id: A0A6D2WTS8
uniprot id: Q5RC09
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9601:IDH3G
gene id: 9601:IDH3G
uniprot id: H2PX63
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9601:RARRES1
gene id: 9601:RARRES1
uniprot id: H2PBV2
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9601:TUBB6
gene id: 9601:TUBB6
uniprot id: H2NVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9601:ELOVL2
gene id: 9601:ELOVL2
uniprot id: H2PHX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9601:ST6GALNAC3
gene id: 9601:ST6GALNAC3
uniprot id: Q5RCN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9601:NID2
gene id: 9601:NID2
uniprot id: H2NL88
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9601:WASHC3
gene id: 9601:WASHC3
uniprot id: H2NIF0
names: Similarity
messages: Belongs to the CCDC53 family.

9601:SLFNL1
gene id: 9601:SLFNL1
uniprot id: A0A2J8Y5Y4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDKN2AIP
gene id: 9601:CDKN2AIP
uniprot id: H2PEU0
names: Similarity
messages: Belongs to the CARF family.

9601:TMEM54
gene id: 9601:TMEM54
uniprot id: H2N838
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9601:TRIM9
gene id: 9601:TRIM9
uniprot id: H2NL85
names: Subcellular Location Annotation
messages: cytoskeleton

9601:HYOU1
gene id: 9601:HYOU1
uniprot id: A0A2J8X0S9
uniprot id: A0A6D2W3S4
uniprot id: Q5R6T2
names: Caution
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TBC1D23
gene id: 9601:TBC1D23
uniprot id: H2P9W9
uniprot id: Q5R8I6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle
messages: Directly interacts with GOLGA1 and GOLGA4. Interacts with FAM91A1, C17ORF75 and WDR11; the interaction recruits TBC1D23 to AP-1-derived vesicles. Directly interacts with WASHC1 and WASHC2A/FAM21A. Interacts with FKBP15.
messages: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).
messages: trans-Golgi network

9601:MAP1LC3A
gene id: 9601:MAP1LC3A
uniprot id: A0A6D2VV38
names: Similarity
messages: Belongs to the ATG8 family.

9601:LOC100435391
gene id: 9601:LOC100435391
uniprot id: A0A2J8S4W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:DPPA5
gene id: 9601:DPPA5
uniprot id: H2PJK5
names: Similarity
messages: Belongs to the KHDC1 family.

9601:SCRN2
gene id: 9601:SCRN2
uniprot id: H2NVG0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9601:DNAJB4
gene id: 9601:DNAJB4
uniprot id: Q5R8J8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.
messages: Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).

9601:FAM19A2
gene id: 9601:FAM19A2
uniprot id: Q5R6N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAFA family.
messages: Cytoplasm
messages: Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions.
messages: Nucleus

9601:NEUROD1
gene id: 9601:NEUROD1
uniprot id: A0A663DBB7
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM42
gene id: 9601:TMEM42
uniprot id: A0A2J8WXI1
uniprot id: Q5R7Q1
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OVCA2
gene id: 9601:OVCA2
uniprot id: A0A2J8SP15
names: Similarity
messages: Belongs to the LovG family.

9601:XRN2
gene id: 9601:XRN2
uniprot id: Q5R4L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Interacts with POLR2A and SMN1/SMN2. Interacts with CDKN2AIP and NKRF. Interacts with CDKN2AIPNL; the interaction is direct. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity).
messages: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).
messages: nucleolus

9601:EIF4EBP2
gene id: 9601:EIF4EBP2
uniprot id: H2NAN4
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9601:ST3GAL4
gene id: 9601:ST3GAL4
uniprot id: H2NFU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9601:SH2B3
gene id: 9601:SH2B3
uniprot id: H2NIN8
names: Similarity
messages: Belongs to the SH2B adapter family.

9601:FAM210A
gene id: 9601:FAM210A
uniprot id: Q5RE99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM210 family.
messages: Cytoplasm
messages: Interacts with ATAD3A.
messages: May play a role in the structure and strength of both muscle and bone.
messages: Membrane
messages: Mitochondrion

9601:MAP3K3
gene id: 9601:MAP3K3
uniprot id: A0A2J8UZE5
uniprot id: A0A2J8UZF7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GBF1
gene id: 9601:GBF1
uniprot id: H2NBF0
names: Subcellular Location Annotation
messages: Golgi apparatus

9601:SEPT10
gene id: 9601:SEPT10
uniprot id: A0A2J8SGQ9
uniprot id: H2P5C9
uniprot id: Q5REF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9601:EIF4A3
gene id: 9601:EIF4A3
uniprot id: H2NUY8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9601:PPEF1
gene id: 9601:PPEF1
uniprot id: H2PV22
names: Similarity
messages: Belongs to the PPP phosphatase family.

9601:DOK4
gene id: 9601:DOK4
uniprot id: Q5RA30
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the DOK family. Type B subfamily.
messages: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity).
messages: Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET (By similarity).
messages: PTB domain mediates receptor interaction.
messages: Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.

9601:PTTG1IP
gene id: 9601:PTTG1IP
uniprot id: Q5NVI6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with PTTG1.
messages: May facilitate PTTG1 nuclear translocation.
messages: Nucleus

9601:ZNF490
gene id: 9601:ZNF490
uniprot id: K7ETC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:KIAA1024L
gene id: 9601:KIAA1024L
uniprot id: H2PGF8
names: Similarity
messages: Belongs to the MINAR family.

9601:DAD1
gene id: 9601:DAD1
uniprot id: Q5RBB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9601:PIK3CB
gene id: 9601:PIK3CB
uniprot id: A0A6D2YAW0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9601:GCH1
gene id: 9601:GCH1
uniprot id: A0A2J8WKZ4
uniprot id: A0A6D2WVB1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9601:LOC100438526
gene id: 9601:LOC100438526
uniprot id: A0A6D2WXS3
names: Subcellular Location Annotation
messages: Membrane

9601:SLC1A2
gene id: 9601:SLC1A2
uniprot id: A0A2J8WFT7
uniprot id: H2NDP7
uniprot id: Q5R6A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9601:SIGMAR1
gene id: 9601:SIGMAR1
uniprot id: A0A663DFN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9601:LOC100939208
gene id: 9601:LOC100939208
uniprot id: A0A6D2X4C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:DCAF8
gene id: 9601:DCAF8
uniprot id: Q5R448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF8 family.
messages: Cytoplasm
messages: Interacts with DDB1, CUL4A and CUL4B. Interacts with KPNA1, KPNB1 and XPO1.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
messages: Nucleus

9601:STX1A
gene id: 9601:STX1A
uniprot id: Q5R4L2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Cell membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex constitutes the basic catalytic machinery of the complex neurotransmitter release apparatus. The SNARE complex interacts with CPLX1. Interacts with STXBP1. Interacts (via C-terminus) with KCNB1 (via C-terminus); the interaction increases in a calcium-dependent manner and induces a pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons (By similarity). Interacts with SYTL4 (By similarity). Interacts with STXBP6. Interacts with PLCL1 (via C2 domain) (By similarity). Interacts with OTOF. Interacts with LGI3 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Interacts with VAMP8. Interacts with SNAP23 (By similarity). Interacts with VAPA and SYBU (By similarity). Interacts with PRRT2 (By similarity). Interacts with SEPT8 (By similarity). Interacts with STXBP5L (By similarity). Interacts with synaptotagmin-1/SYT1 (By similarity). Interacts with SEPTIN5; in the cerebellar cortex (By similarity). Interacts with SEPTIN4; in the striatum (By similarity).
messages: Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity).
messages: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (By similarity). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).
messages: Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.
messages: synaptic vesicle membrane
messages: synaptosome

9601:ATP6V1H
gene id: 9601:ATP6V1H
uniprot id: A0A2J8UN40
uniprot id: Q5R8M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9601:CACNB3
gene id: 9601:CACNB3
uniprot id: A0A2J8SYV7
uniprot id: H2NH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9601:NUDC
gene id: 9601:NUDC
uniprot id: H2N8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9601:IDE
gene id: 9601:IDE
uniprot id: A0A8I5TXH8
uniprot id: H2NB07
names: Similarity
messages: Belongs to the peptidase M16 family.

9601:ASPDH
gene id: 9601:ASPDH
uniprot id: H2NZS4
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9601:RPAP1
gene id: 9601:RPAP1
uniprot id: H2NMX5
uniprot id: Q5R8S6
names: Similarity
messages: Belongs to the RPAP1 family.

9601:SHROOM1
gene id: 9601:SHROOM1
uniprot id: A0A6D2XPD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9601:AP2S1
gene id: 9601:AP2S1
uniprot id: A0A2J8U718
uniprot id: Q5R940
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: coated pit

9601:MAP4
gene id: 9601:MAP4
uniprot id: A0A663D5B1
uniprot id: H2PAV8
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:CYP4F12
gene id: 9601:CYP4F12
uniprot id: Q5R8G0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:NDUFC1
gene id: 9601:NDUFC1
uniprot id: H2PEC2
uniprot id: P0CB69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:DOLPP1
gene id: 9601:DOLPP1
uniprot id: A0A2J8UJM3
uniprot id: H2PTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9601:INSL6
gene id: 9601:INSL6
uniprot id: H2PS82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

9601:BAIAP2
gene id: 9601:BAIAP2
uniprot id: A0A2J8Y2H2
uniprot id: A0A663DI47
uniprot id: H2NV04
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9601:LOC100443259
gene id: 9601:LOC100443259
uniprot id: H2PI61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9601:CAST
gene id: 9601:CAST
uniprot id: Q5RCZ4
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9601:PPP1CC
gene id: 9601:PPP1CC
uniprot id: H2NIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9601:HTR1D
gene id: 9601:HTR1D
uniprot id: H2N8N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9601:RPL38
gene id: 9601:RPL38
uniprot id: A0A6D2WIN9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9601:HSD11B1L
gene id: 9601:HSD11B1L
uniprot id: A0A2J8SC59
uniprot id: A0A2J8SC62
uniprot id: A0A6D2WCB5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:YWHAB
gene id: 9601:YWHAB
uniprot id: A0A2J8XVX2
uniprot id: A4K2U9
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).
messages: Inferred by similarity.
messages: Isoform Short contains a N-acetylmethionine at position 1.
messages: Melanosome
messages: The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TGFB2
gene id: 9601:TGFB2
uniprot id: A0A2J8RS20
uniprot id: H2N3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9601:HMGN5
gene id: 9601:HMGN5
uniprot id: H2PW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9601:LOC100460063
gene id: 9601:LOC100460063
uniprot id: H2NE13
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:FSBP
gene id: 9601:FSBP
uniprot id: A0A2J8UGC8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GRK5
gene id: 9601:GRK5
uniprot id: Q5REF7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9601:COX7B
gene id: 9601:COX7B
uniprot id: A0A2J8UT14
uniprot id: Q5R9K2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TREM1
gene id: 9601:TREM1
uniprot id: A0A2J8Y401
uniprot id: Q5RDA5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
messages: Membrane
messages: Monomer. Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VNN3
gene id: 9601:VNN3
uniprot id: K7EW02
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9601:KIF2B
gene id: 9601:KIF2B
uniprot id: H2NTL3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9601:PENK
gene id: 9601:PENK
uniprot id: A0A6D2Y9B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9601:SPATA22
gene id: 9601:SPATA22
uniprot id: A0A2J8SP95
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IFNB1
gene id: 9601:IFNB1
uniprot id: H2PS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:CTH
gene id: 9601:CTH
uniprot id: Q5RFI1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9601:LOC100450216
gene id: 9601:LOC100450216
uniprot id: H2P2W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9601:PRRT2
gene id: 9601:PRRT2
uniprot id: Q5RAC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation.
messages: Belongs to the CD225/Dispanin family.
messages: Cell membrane
messages: Component of the outer core of AMPAR complex (By similarity). AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity). Interacts with intersectin 1/ITSN1. Interacts with SNARE complex components, including SNAP25, STX1A, SYT1 and SYT2; this interaction may inhibit SNARE complex formation (By similarity).
messages: Postsynaptic density membrane
messages: Presynaptic cell membrane
messages: Synapse
messages: axon
messages: dendritic spine
messages: synaptic vesicle membrane

9601:ADAM11
gene id: 9601:ADAM11
uniprot id: Q5R6S9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:SYT4
gene id: 9601:SYT4
uniprot id: A0A2J8XF75
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POLR2F
gene id: 9601:POLR2F
uniprot id: A0A2J8UWD5
uniprot id: Q5R592
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CXHXorf36
gene id: 9601:CXHXorf36
uniprot id: A0A2J8WIM5
uniprot id: A0A2J8WIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9601:CSF3
gene id: 9601:CSF3
uniprot id: A0A2J8WA54
uniprot id: A0A2J8WA76
uniprot id: H2NU88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF566
gene id: 9601:ZNF566
uniprot id: A0A6D2WFE4
uniprot id: Q5RCW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SHISA5
gene id: 9601:SHISA5
uniprot id: Q5RDV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shisa family.
messages: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
messages: Endoplasmic reticulum membrane
messages: Interacts with PDCD6; PDCD6 can stabilze SHISA5.
messages: Nucleus membrane
messages: The proline-rich region is required for endoplasmic reticulum localization.

9601:TGM6
gene id: 9601:TGM6
uniprot id: A0A2J8VI43
uniprot id: H2P1E9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:SLC25A27
gene id: 9601:SLC25A27
uniprot id: Q5NVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:GINS1
gene id: 9601:GINS1
uniprot id: H2P193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9601:TMEM56
gene id: 9601:TMEM56
uniprot id: H2N6P9
names: Subcellular Location Annotation
messages: Membrane

9601:AGO1
gene id: 9601:AGO1
uniprot id: H2N806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9601:HMX2
gene id: 9601:HMX2
uniprot id: A0A2J8W6C3
names: Subcellular Location Annotation
messages: Nucleus

9601:CCDC39
gene id: 9601:CCDC39
uniprot id: A0A2J8WGW9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cilium axoneme

9601:MED29
gene id: 9601:MED29
uniprot id: Q5RBZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 29 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer (By similarity).
messages: Nucleus

9601:CXCR6
gene id: 9601:CXCR6
uniprot id: A0A6D2WSF4
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9601:MKX
gene id: 9601:MKX
uniprot id: A0A6D2XGW9
uniprot id: Q5R6P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: May act as a morphogenetic regulator of cell adhesion.
messages: Nucleus

9601:MTO1
gene id: 9601:MTO1
uniprot id: A0A2J8RYN4
uniprot id: Q5RB71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRDX1
gene id: 9601:PRDX1
uniprot id: A0A6D2VYG0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9601:APEX1
gene id: 9601:APEX1
uniprot id: A0A6D2WZ17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9601:TSR1
gene id: 9601:TSR1
uniprot id: Q5R434
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
messages: Required during maturation of the 40S ribosomal subunit in the nucleolus.
messages: nucleolus

9601:BABAM1
gene id: 9601:BABAM1
uniprot id: A0A2J8T6F8
uniprot id: Q5R7L2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RIDA
gene id: 9601:RIDA
uniprot id: H2PQW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9601:GGT1
gene id: 9601:GGT1
uniprot id: H2P3V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9601:ACAD8
gene id: 9601:ACAD8
uniprot id: H2NFX3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9601:THOC6
gene id: 9601:THOC6
uniprot id: H2NPX2
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9601:CD5L
gene id: 9601:CD5L
uniprot id: H2N5A1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:PCDH18
gene id: 9601:PCDH18
uniprot id: A0A2J8XP89
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPL23
gene id: 9601:MRPL23
uniprot id: H2NCF6
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9601:ROBO4
gene id: 9601:ROBO4
uniprot id: A0A2J8X002
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:USP33
gene id: 9601:USP33
uniprot id: Q5REG5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Interacts with VHL, leading to its ubiquitination and subsequent degradation (By similarity). Interacts with ARRB1 and ARRB2 (By similarity). Interacts with ADRB2 (By similarity). Interacts with DIO2 (By similarity). Interacts with ROBO1 (By similarity). Interacts with SELENBP1; in a selenium-dependent manner (By similarity). Interacts with CCP110 (By similarity). Interacts with ADRB2 (By similarity).
messages: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
messages: Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
messages: centrosome
messages: perinuclear region

9601:CCKAR
gene id: 9601:CCKAR
uniprot id: H2PD27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9601:CCDC172
gene id: 9601:CCDC172
uniprot id: H2NBQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9601:ITM2A
gene id: 9601:ITM2A
uniprot id: A0A2J8USY1
uniprot id: H2PW44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9601:PHYHIPL
gene id: 9601:PHYHIPL
uniprot id: A0A2J8WQX5
uniprot id: H2NAU6
names: Similarity
messages: Belongs to the PHYHIP family.

9601:MARCKS
gene id: 9601:MARCKS
uniprot id: A0A663DHI7
names: Similarity
messages: Belongs to the MARCKS family.

9601:RER1
gene id: 9601:RER1
uniprot id: A0A2J8URG1
uniprot id: Q5R5U4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Golgi apparatus membrane
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DIXDC1
gene id: 9601:DIXDC1
uniprot id: A0A2J8X1Y6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HDAC3
gene id: 9601:HDAC3
uniprot id: Q5RB76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (By similarity). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14 and RARA. Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: …
messages: Interacts with HDAC7 and HDAC9. Interacts with HDAC10, DAXX and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Interacts with SMRT/NCOR2 and BCL6 on DNA enhancer elements. Interacts with INSM1. Interacts with XBP1; the interaction occurs in endothelial cell (EC) under disturbed flow. Interacts (via C-terminus) with CCAR2 (via N-terminus). Interacts with and deacetylates MEF2D. Interacts with BEND3. Interacts with NKAPL. Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts weakly with CRY1; this interaction is enhanced in the presence of FBXL3 (By similarity). Interacts with FBXL3 and BMAL1 (By similarity). Interacts with NCOR1 (By similarity). Interacts with RARA (By similarity). Interacts with SETD5 (By similarity).
messages: Nucleus
messages: cytosol

9601:ZNF445
gene id: 9601:ZNF445
uniprot id: A0A6D2WJM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SCIMP
gene id: 9601:SCIMP
uniprot id: A0A2J8R7W5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARL3
gene id: 9601:ARL3
uniprot id: A0A6D2VVX5
uniprot id: Q5RCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytoplasm
messages: Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Interacts with SYS1. Interacts with ARL2BP; the GTP-bound form interacts with ARL2BP. Microtubule-associated protein. Does not interact with TBCC (By similarity). Interacts with RP2. Interacts with PDE6D; the interaction occurs specifically with the GTP-bound form of ARL3. Interacts with GGA1; the interaction recruits PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting of PKD1:PKD2 complex (By similarity). Interacts with DNAAF9 (By similarity).
messages: Golgi apparatus membrane
messages: Nucleus
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
messages: centrosome
messages: cilium
messages: spindle

9601:PMP2
gene id: 9601:PMP2
uniprot id: H2PQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9601:LCE5A
gene id: 9601:LCE5A
uniprot id: H2N5S6
names: Similarity
messages: Belongs to the LCE family.

9601:SLC6A11
gene id: 9601:SLC6A11
uniprot id: H2PA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9601:HS6ST3
gene id: 9601:HS6ST3
uniprot id: A0A2J8X8Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9601:LOC100442905
gene id: 9601:LOC100442905
uniprot id: H2P0W0
names: Similarity
messages: Belongs to the PRAME family.

9601:GRM7
gene id: 9601:GRM7
uniprot id: Q5RDQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity).
messages: Homodimer (By similarity). Interacts with PICK1.

9601:INPP5J
gene id: 9601:INPP5J
uniprot id: A0A2J8UVB9
uniprot id: A0A2J8UVC1
uniprot id: A0A2J8UVC5
uniprot id: A0A2J8UVC7
uniprot id: H2P436
names: Caution
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNIH4
gene id: 9601:CNIH4
uniprot id: Q5R9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cornichon family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Interacts with Sec23/24 complex components SEC24B and SEC24D (By similarity). Interacts with CCR5 (By similarity). Interacts with ADRB2 in the early secretory pathway (By similarity).
messages: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.
messages: Membrane

9601:LOC100447281
gene id: 9601:LOC100447281
uniprot id: H2NXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SLC35B1
gene id: 9601:SLC35B1
uniprot id: H2NVL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9601:PALMD
gene id: 9601:PALMD
uniprot id: H2N6N9
names: Similarity
messages: Belongs to the paralemmin family.

9601:CDC25A
gene id: 9601:CDC25A
uniprot id: A0A2J8TFU5
uniprot id: H2PAV5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9601:PLXNB2
gene id: 9601:PLXNB2
uniprot id: Q5RAK5
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:ELAVL2
gene id: 9601:ELAVL2
uniprot id: A0A2J8XIH7
uniprot id: A0A2J8XIH9
uniprot id: Q5R6T3
uniprot id: Q5R9Z6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RRM elav family.
messages: Interacts with IGF2BP1 (By similarity). Interacts with MAP1B light chain LC1 (By similarity).
messages: RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RAF1
gene id: 9601:RAF1
uniprot id: A0A2J8TVZ9
uniprot id: Q5R5M7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Methylated at Arg-563 in response to EGF treatment. This modification leads to destabilization of the protein, possibly through proteasomal degradation.
messages: Mitochondrion
messages: Monomer. Homodimer. Heterodimerizes with BRAF and this heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer. Forms a multiprotein complex with Ras (M-Ras/MRAS), SHOC2 and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with LZTR1. Interacts with Ras proteins; the interaction is antagonized by RIN1 (By similarity). Weakly interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with BRAF, a ternary complex inhibited by GNAI1 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Interacts with STK3/MST2; the interaction inhibits its pro-apoptotic activity. Interacts (when phosphorylated at Ser-259) with YWHAZ (unphosphorylated at 'Thr-232') (By similarity). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2 (By similarity). Interacts with MAP3K5/ASF1 (via N-terminus) and this interaction inhibits the proapoptotic function of MAP3K5/ASK1. Interacts with PAK1 (via kinase domain) (By similarity). The phosphorylated form interacts with PIN1 (By similarity). The Ser-338 and Ser-339 phosphorylated form (by PAK1) interacts with BCL2. Interacts with PEBP1/RKIP and this interaction is enhanced if RAF1 is phosphorylated on residues Ser-338, Ser-339, Tyr-340 and Tyr-341. Interacts with ADCY2, ADCY5, ADCY6, DGKH, RCAN1/DSCR1, PPP1R12A, PKB/AKT1, PPP2CA, PPP2R1B, SPRY2, SPRY4, CNKSR1/CNK1, KSR2 and PHB/prohibitin (By similarity). Interacts with ROCK2 (By similarity). In its active form, interacts with PRMT5. Interacts with FAM83B; displaces 14-3-3 proteins from RAF1 and activates RAF1. Inte…
messages: Nucleus
messages: Phosphorylation at Thr-269, Ser-338, Tyr-341, Thr-491 and Ser-494 results in its activation. Phosphorylation at Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2 results in its inactivation. Phosphorylation at Ser-259 induces the interaction with YWHAZ and inactivates kinase activity. Dephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at Ser-338 by PAK1 and PAK5 and Ser-339 by PAK1 is required for its mitochondrial localization (By similarity). Phosphorylation at Ser-621 in response to growth factor treatment stabilizes the protein, possibly by preventing proteasomal degradation. Phosphorylation at Ser-289, Ser-296, Ser-301, Ser-338 and Ser-621 are somehow linked to the methylation potential of cells. Treatment of cells with HGF in the presence of the methylation inhibitor 5'-methylthioadenosine (MTA) results in increased phosphorylation at Ser-338 and Ser-621 and decreased phosphorylation at Ser-296, Ser-301 and Ser-338. Dephosphorylation at Ser-338 by PPP5C results in a decreased of activity (By similarity).
messages: Regulation is a highly complex process involving membrane recruitment, protein-protein interactions, dimerization, and phosphorylation/dephosphorylation events. Ras-GTP recruits RAF1 to the membrane, thereby promoting its activation. The inactive conformation of RAF1 is maintained by autoinhibitory interactions occurring between the N-terminal regulatory and the C-terminal catalytic domains and by the binding of a 14-3-3 protein that contacts two phosphorylation sites, Ser-259 and Ser-621. Upon mitogenic stimulation, Ras and PPP2R1A cooperate to release autoinhibition and the subsequent phosphorylation of activating sites: Ser-338, Tyr-341, Thr-491, and Ser-494, yields a fully active kinase. Through a negative feedback mechanism involving MAPK1/ERK2, RAF1 is phosphorylated on Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2, which yields an inactive, desensitized kinase. The signaling-competent conformation of RAF1 is finally re-established by the coordinated action of PIN1, a prolyl isomerase that converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A. Activated by homodimerization and heterodimerization (with BRAF). Also regulated through association with other proteins such as KSR2, CNKSR1/CNK1, PEBP1/RKIP, PHB/prohibitin and SPRY4. PEBP1/RKIP acts by dissociating RAF1 from its substrates MAP2K1/MEK1 and MAP2K2/MEK2. PHB/prohibitin facilitates the displacement of 14-3-3 from RAF1 by activated Ras, thereby promoting cell membrane localization and phosphorylation of RAF1 at the activating Ser-338. SPRY4 inhibits Ras-independent, but not Ras-dependent, activation of RAF1. CNKSR1/CNK1 regulates Src-mediated RAF1 activation (By similarity).
messages: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HGH1
gene id: 9601:HGH1
uniprot id: H2PRG0
names: Similarity
messages: Belongs to the HGH1 family.

9601:MRS2
gene id: 9601:MRS2
uniprot id: Q5R447
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits.
messages: Mitochondrion inner membrane

9601:HYLS1
gene id: 9601:HYLS1
uniprot id: A0A2J8WZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9601:NSMCE1
gene id: 9601:NSMCE1
uniprot id: Q5RAZ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5-SMC6 heterodimer. Interacts with NSMCE3.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair.
messages: Ubiquitinated.
messages: telomere

9601:IARS2
gene id: 9601:IARS2
uniprot id: H2N3N9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9601:DNAJC25
gene id: 9601:DNAJC25
uniprot id: H2PT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9601:SATB1
gene id: 9601:SATB1
uniprot id: A0A2J8U434
uniprot id: A0A6D2YCQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9601:KEF63 p01
gene id: 9601:KEF63_p01
uniprot id: A0A110AV15
uniprot id: P92701
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9601:MRPS9
gene id: 9601:MRPS9
uniprot id: H2P5A7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9601:OPRD1
gene id: 9601:OPRD1
uniprot id: H2N898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PSMB7
gene id: 9601:PSMB7
uniprot id: H2PTC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9601:HMGA2
gene id: 9601:HMGA2
uniprot id: A0A2J8W0R0
uniprot id: A0A2J8W0R7
uniprot id: A0A2J8W0T9
uniprot id: H2NHY3
uniprot id: H2NHY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9601:ATP5MF
gene id: 9601:ATP5MF
uniprot id: A0A2J8RUD3
uniprot id: H2PLJ1
uniprot id: Q5R6T5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100435184
gene id: 9601:LOC100435184
uniprot id: A0A2J8Y5A6
uniprot id: H2NB14
names: Caution
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100455469
gene id: 9601:LOC100455469
uniprot id: H2NP84
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9601:OTX1
gene id: 9601:OTX1
uniprot id: A0A6D2YAH4
names: Subcellular Location Annotation
messages: Nucleus

9601:TFEC
gene id: 9601:TFEC
uniprot id: A0A2J8UPI7
uniprot id: A0A2J8UPI8
uniprot id: A0A6D2XF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9601:SULF1
gene id: 9601:SULF1
uniprot id: A0A6D2VS67
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9601:IL36B
gene id: 9601:IL36B
uniprot id: H2P5G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9601:LOC100459464
gene id: 9601:LOC100459464
uniprot id: A0A8I5TC66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9601:IRF2BP1
gene id: 9601:IRF2BP1
uniprot id: H2NZA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9601:ACOD1
gene id: 9601:ACOD1
uniprot id: H2NK30
names: Similarity
messages: Belongs to the PrpD family.

9601:LEFTY2
gene id: 9601:LEFTY2
uniprot id: A0A2J8U248
uniprot id: H2N3J7
uniprot id: H2N3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9601:MIF4GD
gene id: 9601:MIF4GD
uniprot id: A0A6D2XXP5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUPL2
gene id: 9601:NUPL2
uniprot id: Q5RB98
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus membrane
messages: O-glycosylated.
messages: Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro (By similarity). Interacts with XPO1 (By similarity).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
messages: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
messages: nuclear pore complex

9601:PGPEP1
gene id: 9601:PGPEP1
uniprot id: A0A663DGG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9601:MRGPRX2
gene id: 9601:MRGPRX2
uniprot id: A0A6D2Y0Q5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LCTL
gene id: 9601:LCTL
uniprot id: H2NNK0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9601:ACSL3
gene id: 9601:ACSL3
uniprot id: Q5R668
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Peroxisome membrane

9601:KEF63 p06
gene id: 9601:KEF63_p06
uniprot id: G0Z9S3
uniprot id: P92697
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9601:SCAF4
gene id: 9601:SCAF4
uniprot id: A0A2J8UKU1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100452187
gene id: 9601:LOC100452187
uniprot id: H2NZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9601:SCG5
gene id: 9601:SCG5
uniprot id: A0A663D9I5
uniprot id: H2NMP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EID2B
gene id: 9601:EID2B
uniprot id: H2NYT3
names: Subcellular Location Annotation
messages: Nucleus

9601:BAMBI
gene id: 9601:BAMBI
uniprot id: H2NA28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9601:MYO1C
gene id: 9601:MYO1C
uniprot id: A0A2J8SNS0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9601:LHFPL1
gene id: 9601:LHFPL1
uniprot id: H2PWI6
names: Subcellular Location Annotation
messages: Membrane

9601:RSPO1
gene id: 9601:RSPO1
uniprot id: A0A2J8Y6M4
uniprot id: A0A6D2VWU5
names: Similarity
messages: Belongs to the R-spondin family.

9601:SETD3
gene id: 9601:SETD3
uniprot id: H2NM82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9601:PLPBP
gene id: 9601:PLPBP
uniprot id: Q5R4Z1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9601:ZNF280B
gene id: 9601:ZNF280B
uniprot id: A0A2J8RZ69
uniprot id: A0A6D2XXF6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC25A42
gene id: 9601:SLC25A42
uniprot id: H2NY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:MBD4
gene id: 9601:MBD4
uniprot id: A0A2J8TVI4
uniprot id: Q5RFD9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RBM8A
gene id: 9601:RBM8A
uniprot id: A0A2J8SQ73
uniprot id: A0A6D2WLD5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100450406
gene id: 9601:LOC100450406
uniprot id: H2N4U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9601:ZMPSTE24
gene id: 9601:ZMPSTE24
uniprot id: Q5R6Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9601:FAM172A
gene id: 9601:FAM172A
uniprot id: A0A2J8TD26
uniprot id: A0A2J8TD91
uniprot id: H2PG33
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NKX6-2
gene id: 9601:NKX6-2
uniprot id: H2NC16
names: Subcellular Location Annotation
messages: Nucleus

9601:ASB4
gene id: 9601:ASB4
uniprot id: H2PMV9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9601:SCARA5
gene id: 9601:SCARA5
uniprot id: H2PPX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9601:PTPN5
gene id: 9601:PTPN5
uniprot id: A0A2J8UQQ2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CALHM4
gene id: 9601:CALHM4
uniprot id: A0A2J8U131
uniprot id: A0A2J8U139
uniprot id: A0A663D5K8
uniprot id: H2PK53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAT
gene id: 9601:TAT
uniprot id: H2NRF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9601:CD38
gene id: 9601:CD38
uniprot id: H2PCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

9601:TMEM59L
gene id: 9601:TMEM59L
uniprot id: A0A6D2X446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:AMER1
gene id: 9601:AMER1
uniprot id: H2PVU5
names: Similarity
messages: Belongs to the Amer family.

9601:ENTPD8
gene id: 9601:ENTPD8
uniprot id: A0A2J8RMB8
uniprot id: A0A6D2Y5T3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9601:SLC26A1
gene id: 9601:SLC26A1
uniprot id: A0A6D2XGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
messages: Membrane

9601:CCL8
gene id: 9601:CCL8
uniprot id: H2NTB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:RPL23A
gene id: 9601:RPL23A
uniprot id: H2NT48
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9601:RPS6
gene id: 9601:RPS6
uniprot id: A0A6D2XT93
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9601:HBEGF
gene id: 9601:HBEGF
uniprot id: H2PGR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:POMGNT1
gene id: 9601:POMGNT1
uniprot id: Q5RCB9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9601:SOD2
gene id: 9601:SOD2
uniprot id: A0A2J8XB16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9601:CEBPB
gene id: 9601:CEBPB
uniprot id: H2P2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9601:PROM1
gene id: 9601:PROM1
uniprot id: A0A2J8ULI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9601:DEFB112
gene id: 9601:DEFB112
uniprot id: H2PJB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9601:SUV39H1
gene id: 9601:SUV39H1
uniprot id: A0A2J8R8M6
uniprot id: Q5RB81
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition (By similarity).
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, CCAR2, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Interacts with LMNA; the interaction increases stability of SUV39H1. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex (By similarity).
messages: Negatively regulated by CCAR2.
messages: Nucleus
messages: Nucleus lamina
messages: Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centromere
messages: nucleoplasm

9601:BRCA1
gene id: 9601:BRCA1
uniprot id: H2NTX3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9601:PEX2
gene id: 9601:PEX2
uniprot id: H2PQL9
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9601:ARRDC3
gene id: 9601:ARRDC3
uniprot id: Q5R5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.
messages: Belongs to the arrestin family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Interacts (via PPxY motifs) with NEDD4 (via WW domains). Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH.
messages: Lysosome

9601:SDC4
gene id: 9601:SDC4
uniprot id: A0A663D6Z8
uniprot id: A4K2W0
uniprot id: Q5RAT9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
messages: Cell surface proteoglycan.
messages: Homodimer. Interacts with CDCP1 and SDCBP. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity).
messages: Membrane
messages: Secreted
messages: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRMU
gene id: 9601:TRMU
uniprot id: A0A2J8TW51
uniprot id: Q5RB73
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF330
gene id: 9601:ZNF330
uniprot id: A0A2J8XNZ9
uniprot id: Q5R9D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centromere
messages: nucleolus

9601:TIE1
gene id: 9601:TIE1
uniprot id: H2N7Q2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:NSG1
gene id: 9601:NSG1
uniprot id: A0A2J8TCI4
uniprot id: Q5RF46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (By similarity).
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
messages: Recycling endosome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

9601:SELENOI
gene id: 9601:SELENOI
uniprot id: Q5NV96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Endoplasmic reticulum membrane
messages: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment.

9601:KIF1B
gene id: 9601:KIF1B
uniprot id: H2N960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9601:BAAT
gene id: 9601:BAAT
uniprot id: A0A6D2WIK2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9601:EIF3G
gene id: 9601:EIF3G
uniprot id: H2NXI4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9601:TEKT1
gene id: 9601:TEKT1
uniprot id: H2NSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9601:BCAT1
gene id: 9601:BCAT1
uniprot id: A0A2J8RFI0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9601:CTC1
gene id: 9601:CTC1
uniprot id: Q5RDX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTC1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability (By similarity). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity).
messages: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with STN1. Interacts with ACD and POT1 (By similarity).
messages: Nucleus
messages: telomere

9601:IRF1
gene id: 9601:IRF1
uniprot id: A0A6D2W8V3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:AAGAB
gene id: 9601:AAGAB
uniprot id: A0A2J8UCA2
uniprot id: Q5RET3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associated with AP-1 and AP-2 complexes.
messages: May be involved in endocytic recycling of growth factor receptors such as EGFR.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:TMEM67
gene id: 9601:TMEM67
uniprot id: A0A6D2XVR5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100457396
gene id: 9601:LOC100457396
uniprot id: A0A8I5TNZ5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9601:EIF2B5
gene id: 9601:EIF2B5
uniprot id: A0A663D7I1
uniprot id: H2PC57
names: Caution
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TCEAL4
gene id: 9601:TCEAL4
uniprot id: Q5R6B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:AMDHD1
gene id: 9601:AMDHD1
uniprot id: H2NIB4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9601:MGMT
gene id: 9601:MGMT
uniprot id: H2NBZ9
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9601:KEF63 p05
gene id: 9601:KEF63_p05
uniprot id: A0A0X8E998
uniprot id: P61795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9601:MERTK
gene id: 9601:MERTK
uniprot id: Q5RDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9601:PDZD7
gene id: 9601:PDZD7
uniprot id: Q5RBI7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimerizes (via PDZ2 domain). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts (via PDZ domains) with WHRN; the interaction is direct (By similarity). Interacts with USH1G. Interacts with ADGRV1 (via the cytoplasmic region). Interacts with USH2A (via the cytoplasmic region) (By similarity). Interacts with MYO7A (via MyTH4-FERM domains) (By similarity).
messages: In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1.
messages: Nucleus
messages: cilium
messages: stereocilium

9601:OSBPL7
gene id: 9601:OSBPL7
uniprot id: A0A6D2W2N5
names: Similarity
messages: Belongs to the OSBP family.

9601:DLGAP4
gene id: 9601:DLGAP4
uniprot id: Q5RC25
names: Similarity
messages: Belongs to the SAPAP family.

9601:RSRP1
gene id: 9601:RSRP1
uniprot id: H2P0T4
names: Similarity
messages: Belongs to the RSRP family.

9601:UBN2
gene id: 9601:UBN2
uniprot id: H2PNN5
names: Similarity
messages: Belongs to the ubinuclein family.

9601:RPL7A
gene id: 9601:RPL7A
uniprot id: A0A6D2YCM5
uniprot id: H2PTU4
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TUBG2
gene id: 9601:TUBG2
uniprot id: H2NTZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9601:LMBR1L
gene id: 9601:LMBR1L
uniprot id: A0A8I5T9R3
uniprot id: Q5RBY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity).
messages: Endoplasmic reticulum membrane
messages: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity).

9601:CCDC124
gene id: 9601:CCDC124
uniprot id: A0A6D2XD19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9601:IKZF3
gene id: 9601:IKZF3
uniprot id: A0A2J8WA10
uniprot id: A0A2J8WA19
uniprot id: A0A2J8WA28
uniprot id: A0A2J8WA41
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PATE2
gene id: 9601:PATE2
uniprot id: A0A663DGH4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TGFB3
gene id: 9601:TGFB3
uniprot id: H2NLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9601:ZFAND6
gene id: 9601:ZFAND6
uniprot id: A0A2J8SKJ8
uniprot id: Q5R7S6
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PKN1. Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).
messages: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
messages: The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.
messages: The AN1-type zinc finger domain mediates association with TRAF2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SGMS1
gene id: 9601:SGMS1
uniprot id: H2NAX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9601:TMIGD2
gene id: 9601:TMIGD2
uniprot id: A0A663D6C4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AFF4
gene id: 9601:AFF4
uniprot id: H2PGJ3
names: Similarity
messages: Belongs to the AF4 family.

9601:MIP
gene id: 9601:MIP
uniprot id: H2NHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9601:PLCG1
gene id: 9601:PLCG1
uniprot id: H2P1Y0
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9601:AGAP2
gene id: 9601:AGAP2
uniprot id: H2NHU9
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9601:LOC100452370
gene id: 9601:LOC100452370
uniprot id: H2NDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ATG5
gene id: 9601:ATG5
uniprot id: A0A2J8SG06
uniprot id: Q5R792
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300.
messages: Belongs to the ATG5 family.
messages: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
messages: Conjugated with ATG12.
messages: Cytoplasm
messages: Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L1. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate. Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection. Interacts with ATG3 (By similarity). Interacts with ATG7 and ATG10 (By similarity). Interacts with FADD (By similarity). Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy (By similarity). Interacts with ATG16L2 (By similarity).
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ENO2
gene id: 9601:ENO2
uniprot id: Q5RA28
names: Similarity
messages: Belongs to the enolase family.

9601:REP15
gene id: 9601:REP15
uniprot id: A0A2J8WBW0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C2BH2orf88
gene id: 9601:C2BH2orf88
uniprot id: A0A6D2W459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9601:IBSP
gene id: 9601:IBSP
uniprot id: H2PDV2
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9601:RPS19
gene id: 9601:RPS19
uniprot id: A0A2J8SEH3
uniprot id: Q5R8M9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IGFBP6
gene id: 9601:IGFBP6
uniprot id: H2NHF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:TOR3A
gene id: 9601:TOR3A
uniprot id: H2N4J7
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9601:AARS2
gene id: 9601:AARS2
uniprot id: H2PJ76
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9601:ANXA2
gene id: 9601:ANXA2
uniprot id: A0A2J8T8S2
uniprot id: Q5R5A0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity).
messages: ISGylated.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: basement membrane

9601:RBM39
gene id: 9601:RBM39
uniprot id: A0A2J8VJA4
uniprot id: Q5RC80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Interacts with NCOA6 and JUN. Interacts with ESR1 and ESR2, in the presence of estradiol (E2). Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with SF3B1. Interacts with ZNF106 (via N-terminus).
messages: Nucleus speckle
messages: RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing (By similarity). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HNRNPA3
gene id: 9601:HNRNPA3
uniprot id: Q5RCK0
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100452836
gene id: 9601:LOC100452836
uniprot id: H2PXA5
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9601:DUSP6
gene id: 9601:DUSP6
uniprot id: H2NI77
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9601:GRK2
gene id: 9601:GRK2
uniprot id: H2NCP1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9601:IL10
gene id: 9601:IL10
uniprot id: H2N3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9601:FAM114A1
gene id: 9601:FAM114A1
uniprot id: H2PD42
names: Similarity
messages: Belongs to the FAM114 family.

9601:CPSF3
gene id: 9601:CPSF3
uniprot id: Q5R428
names: Subcellular Location Annotation
messages: Nucleus

9601:ITGB3BP
gene id: 9601:ITGB3BP
uniprot id: A0A6D2XQ41
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9601:ARSJ
gene id: 9601:ARSJ
uniprot id: Q5R8L1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9601:SLC12A1
gene id: 9601:SLC12A1
uniprot id: A0A2J8VB87
uniprot id: A0A2J8VBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9601:TAF10
gene id: 9601:TAF10
uniprot id: H2NE90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9601:DLX2
gene id: 9601:DLX2
uniprot id: H2P7U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9601:NOL11
gene id: 9601:NOL11
uniprot id: Q5RB52
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner. May associate with the proposed t-UTP subcomplex of the SSU processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.
messages: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity).
messages: nucleolus

9601:WRN
gene id: 9601:WRN
uniprot id: Q5RDV4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9601:ZNF547
gene id: 9601:ZNF547
uniprot id: Q5RCX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:SLC37A4
gene id: 9601:SLC37A4
uniprot id: Q5RF35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9601:NR1H2
gene id: 9601:NR1H2
uniprot id: Q5REL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9601:BECN2
gene id: 9601:BECN2
uniprot id: H2N396
names: Similarity
messages: Belongs to the beclin family.

9601:C7H7orf25
gene id: 9601:C7H7orf25
uniprot id: A0A2J8STE9
uniprot id: A0A6D2XFL5
names: Caution
names: Similarity
messages: Belongs to the UPF0415 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RABL2B
gene id: 9601:RABL2B
uniprot id: A0A2J8XTL8
uniprot id: A0A6D2WZF6
uniprot id: Q5R573
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.
messages: Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPARGC1B
gene id: 9601:PPARGC1B
uniprot id: A0A8I5UAW2
uniprot id: H2PH19
names: Subcellular Location Annotation
messages: Nucleus

9601:REEP4
gene id: 9601:REEP4
uniprot id: A0A2J8X4G4
uniprot id: Q5R598
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FGF18
gene id: 9601:FGF18
uniprot id: H2PHC7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9601:LARS2
gene id: 9601:LARS2
uniprot id: A0A2J8WXD1
uniprot id: A0A6D2VSW9
uniprot id: Q5RDP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9601:LOC100462573
gene id: 9601:LOC100462573
uniprot id: H2PI41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:RMC1
gene id: 9601:RMC1
uniprot id: A0A2J8XGR6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RDH10
gene id: 9601:RDH10
uniprot id: H2PQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9601:CPO
gene id: 9601:CPO
uniprot id: H2P8F0
names: Similarity
messages: Belongs to the peptidase M14 family.

9601:LOC100442029
gene id: 9601:LOC100442029
uniprot id: H2PHE0
names: Similarity
messages: Belongs to the PPase family.

9601:HTR1E
gene id: 9601:HTR1E
uniprot id: H2PJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PDGFD
gene id: 9601:PDGFD
uniprot id: A0A2J8XX72
uniprot id: Q5RA73
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form (By similarity).
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HDC
gene id: 9601:HDC
uniprot id: H2NN75
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9601:PFKM
gene id: 9601:PFKM
uniprot id: A0A8I3B2S8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:SPIN2B
gene id: 9601:SPIN2B
uniprot id: A0A2J8RU37
uniprot id: A0A6D2WI60
uniprot id: Q5RA80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPIN/STSY family.
messages: Interacts with C11orf84/SPINDOC.
messages: May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LAMTOR3
gene id: 9601:LAMTOR3
uniprot id: Q5R3Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
messages: Belongs to the LAMTOR3 family.
messages: Late endosome membrane
messages: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (By similarity). Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).

9601:ARHGEF11
gene id: 9601:ARHGEF11
uniprot id: H2N5A9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9601:SLC33A1
gene id: 9601:SLC33A1
uniprot id: A0A6D2X9L5
names: Subcellular Location Annotation
messages: Membrane

9601:STAT5A
gene id: 9601:STAT5A
uniprot id: A0A2J8RF47
uniprot id: A0A2J8RF61
uniprot id: A0A6D2WCR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RASGRF1
gene id: 9601:RASGRF1
uniprot id: A0A2J8SKM9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SFXN2
gene id: 9601:SFXN2
uniprot id: A0A2J8XYM0
uniprot id: H2NBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9601:PARM1
gene id: 9601:PARM1
uniprot id: Q5RAF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARM family.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Highly N-glycosylated and O-glycosylated.
messages: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.

9601:LOC100447128
gene id: 9601:LOC100447128
uniprot id: A0A2J8Y362
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CA2
gene id: 9601:CA2
uniprot id: H2PQQ1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9601:AKT2
gene id: 9601:AKT2
uniprot id: H2NYU6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9601:RBM7
gene id: 9601:RBM7
uniprot id: A0A2J8X1K3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PARP4
gene id: 9601:PARP4
uniprot id: Q5R9I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9601:LBX2
gene id: 9601:LBX2
uniprot id: A0A2J8XB45
names: Subcellular Location Annotation
messages: Nucleus

9601:RAB33A
gene id: 9601:RAB33A
uniprot id: H2PWR7
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9601:BSDC1
gene id: 9601:BSDC1
uniprot id: A0A2J8Y792
uniprot id: A0A6D2W5Z9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASPA
gene id: 9601:ASPA
uniprot id: Q5R794
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9601:TSPAN3
gene id: 9601:TSPAN3
uniprot id: A0A2J8RQP8
uniprot id: A0A2J8RQQ6
uniprot id: A0A2J8RQU5
uniprot id: A0A8J9GKM2
uniprot id: Q5RE11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Interacts with claudin-11/CLDN11 and integrins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TP53I11
gene id: 9601:TP53I11
uniprot id: A0A2J8WFH9
uniprot id: Q5REI9
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:B3GALT4
gene id: 9601:B3GALT4
uniprot id: H2PL54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:IMP4
gene id: 9601:IMP4
uniprot id: A0A2J8XSP7
uniprot id: Q5R947
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:SNX30
gene id: 9601:SNX30
uniprot id: H2PT32
names: Similarity
messages: Belongs to the sorting nexin family.

9601:NDUFS7
gene id: 9601:NDUFS7
uniprot id: A0A2J8R9N9
uniprot id: P0CB83
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAS2R42
gene id: 9601:TAS2R42
uniprot id: H2NGL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:GSTM2
gene id: 9601:GSTM2
uniprot id: Q5R8E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers.
messages: Cytoplasm
messages: Homodimer.

9601:APOO
gene id: 9601:APOO
uniprot id: H2PV48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9601:MRPL16
gene id: 9601:MRPL16
uniprot id: Q5R7L3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9601:LTF
gene id: 9601:LTF
uniprot id: H2PAY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

9601:DYNC1I2
gene id: 9601:DYNC1I2
uniprot id: A0A2J8VQV7
uniprot id: Q5NVM2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
messages: Belongs to the dynein intermediate chain family.
messages: Cytoplasm
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT3. Interacts with DYNLT1. Interacts (dephosphorylated at Ser-90) with DCTN1 (By similarity). Interacts with BICD2. Interacts with SPEF2 (By similarity).
messages: Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) promotes interaction with DCTN1. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.
messages: The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:BECN1
gene id: 9601:BECN1
uniprot id: A0A2J8REU4
uniprot id: Q5R878
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (By similarity). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1 and AMBRA1 (By similarity). PI3KC3-C1 probably associates with PIK3CB (By similarity). Interacts with AMBRA1, GOPC, GRID2 (By similarity). Forms a complex with PPP2CA and AMBRA1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways. Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex. Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with USP10, USP13, VMP1, DAPK1, RAB39A. Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-402 and stabilizes BECN1. Interacts with SLAMF1. Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Interacts with active ULK1 (phosphorylated on 'Ser-317') and MEFV simultaneously. Interacts with WDR81 and WDR91; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes. Interacts with LAPTM4B; competes with…
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy.
messages: Plays a central role in autophagy.
messages: Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity).
messages: Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (By similarity). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (By similarity). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (By similarity). Polyubiquitinated at Lys-402 with 'Lys-48'-linkages (By similarity). 'Lys-48'-linked polyubiquitination of Lys-402 leads to degradation (By similarity). Deubiquitinated by ATXN3, leading to stabilization (By similarity). Ubiquitinated at Lys-437 via 'Lys-63'-linkage by the DCX(AMBRA1) complex, thereby increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity).
messages: Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.
messages: The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD (By similarity). As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: autophagosome
messages: trans-Golgi network membrane

9601:MMACHC
gene id: 9601:MMACHC
uniprot id: H2N7L0
names: Similarity
messages: Belongs to the MMACHC family.

9601:KARS
gene id: 9601:KARS
uniprot id: Q5RFG7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9601:SMDT1
gene id: 9601:SMDT1
uniprot id: H2P4L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9601:MPDU1
gene id: 9601:MPDU1
uniprot id: H2NSK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9601:DPM1
gene id: 9601:DPM1
uniprot id: H2P2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9601:CLTC
gene id: 9601:CLTC
uniprot id: A0A663D8W8
uniprot id: H2NV97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: coated pit

9601:SLC16A12
gene id: 9601:SLC16A12
uniprot id: H2NAY9
names: Subcellular Location Annotation
messages: Membrane

9601:MED28
gene id: 9601:MED28
uniprot id: A0A663D5Y6
uniprot id: H2PCZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9601:CREB1
gene id: 9601:CREB1
uniprot id: A0A2J8WUD9
uniprot id: Q5RD15
names: Subcellular Location Annotation
messages: Nucleus

9601:BID
gene id: 9601:BID
uniprot id: Q5R7P9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9601:GPBP1
gene id: 9601:GPBP1
uniprot id: Q5R4E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vasculin family.
messages: Functions as a GC-rich promoter-specific transactivating transcription factor.
messages: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.
messages: Nucleus

9601:SLC17A8
gene id: 9601:SLC17A8
uniprot id: A0A2J8XMJ6
uniprot id: H2NID6
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100459848
gene id: 9601:LOC100459848
uniprot id: A0A2J8XZL0
uniprot id: A0A6D2XMV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:INHBE
gene id: 9601:INHBE
uniprot id: A0A663DEJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9601:PRM2
gene id: 9601:PRM2
uniprot id: A0A6D2XXY2
uniprot id: H2NQ53
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC25A10
gene id: 9601:SLC25A10
uniprot id: H2NV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:SNX14
gene id: 9601:SNX14
uniprot id: A0A2J8V2Q9
uniprot id: Q5R903
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: dendrite

9601:IGFBP3
gene id: 9601:IGFBP3
uniprot id: A0A6D2XFI7
uniprot id: Q5R8I7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:GCLC
gene id: 9601:GCLC
uniprot id: A0A6D2X8D7
uniprot id: H2PJE3
names: Caution
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNRPD1
gene id: 9601:SNRPD1
uniprot id: H2PXL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9601:FOS
gene id: 9601:FOS
uniprot id: A0A6D2W783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9601:AK3
gene id: 9601:AK3
uniprot id: Q5RDZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9601:LOC100448354
gene id: 9601:LOC100448354
uniprot id: H2NKG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CNTF
gene id: 9601:CNTF
uniprot id: K7EVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9601:PRKD1
gene id: 9601:PRKD1
uniprot id: A0A2J8THS3
uniprot id: A0A6D2WJ02
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9601:CAB39L
gene id: 9601:CAB39L
uniprot id: A0A6D2WRP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9601:CLDND1
gene id: 9601:CLDND1
uniprot id: A0A2J8S981
uniprot id: A0A2J8S982
uniprot id: Q5RDV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM150A
gene id: 9601:TMEM150A
uniprot id: A0A6D2XN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9601:ARPC1B
gene id: 9601:ARPC1B
uniprot id: H2PLI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9601:PIK3IP1
gene id: 9601:PIK3IP1
uniprot id: Q5RCS3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.

9601:OSBPL6
gene id: 9601:OSBPL6
uniprot id: A0A2J8VRD5
uniprot id: A0A2J8VRG1
names: Similarity
messages: Belongs to the OSBP family.

9601:DIS3L
gene id: 9601:DIS3L
uniprot id: Q5R5N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity).
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

9601:LOC100452142
gene id: 9601:LOC100452142
uniprot id: H2N618
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:CA10
gene id: 9601:CA10
uniprot id: Q5REN8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9601:MTMR2
gene id: 9601:MTMR2
uniprot id: Q5REB9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Homodimer (via coiled-coil domain). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer. Heterodimer with SBF1/MTMR5. Heterodimer with MTMR12.
messages: Interaction with SBF1/MTMR5 increases phosphatase activity.
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).
messages: Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.
messages: The GRAM domain mediates binding to phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.
messages: The coiled-coil domain mediates homodimerization. Also mediates interaction with SBF1/MTMR5 (By similarity). By mediating MTMR2 homodimerization, indirectly involved in SBF2/MTMR13 and MTMR2 heterotetramerization (By similarity).
messages: axon
messages: perinuclear region

9601:PLG
gene id: 9601:PLG
uniprot id: Q5R8X6
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, resulting in 2 chains held together by 2 disulfide bonds. Without the inhibitor, the activation involves also removal of the activation peptide.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity).
messages: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.
messages: Kringle domains mediate interaction with CSPG4.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
messages: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
messages: Secreted

9601:ELL2
gene id: 9601:ELL2
uniprot id: H2PG50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9601:EGR2
gene id: 9601:EGR2
uniprot id: A0A6D2VVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9601:HSD17B2
gene id: 9601:HSD17B2
uniprot id: H2NRL5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:CD48
gene id: 9601:CD48
uniprot id: A0A2J8VHN8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TGFBR1
gene id: 9601:TGFBR1
uniprot id: A0A663DA69
uniprot id: H2PSV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF226
gene id: 9601:ZNF226
uniprot id: Q5RB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LOC100442896
gene id: 9601:LOC100442896
uniprot id: H2PI50
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:ZNF274
gene id: 9601:ZNF274
uniprot id: A0A6D2W7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:DCTN6
gene id: 9601:DCTN6
uniprot id: Q5R7D8
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1 (By similarity).
messages: Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
messages: cytoskeleton
messages: kinetochore

9601:PTPRM
gene id: 9601:PTPRM
uniprot id: A0A2J8XH26
uniprot id: Q5R4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Cell membrane
messages: Membrane

9601:CNIH2
gene id: 9601:CNIH2
uniprot id: H2NCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9601:TGFA
gene id: 9601:TGFA
uniprot id: A0A2J8XBS7
uniprot id: A0A2J8XBU1
uniprot id: A0A6D2WM37
uniprot id: H2P5X2
uniprot id: Q5R8W2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HMOX2
gene id: 9601:HMOX2
uniprot id: A0A2J8S7B6
uniprot id: H2NQ09
names: Similarity
messages: Belongs to the heme oxygenase family.

9601:MRPS27
gene id: 9601:MRPS27
uniprot id: Q5R661
names: Subcellular Location Annotation
messages: Mitochondrion

9601:PDP1
gene id: 9601:PDP1
uniprot id: Q5RA52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
messages: Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.
messages: Mitochondrion matrix

9601:ARFRP1
gene id: 9601:ARFRP1
uniprot id: A0A2J8R2Z6
uniprot id: Q5R579
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus
messages: Interacts with SYS1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
messages: trans-Golgi network

9601:ALDH16A1
gene id: 9601:ALDH16A1
uniprot id: H2NZN1
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Interacts with SPG21.

9601:BRD8
gene id: 9601:BRD8
uniprot id: A0A803KJQ9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAPK9
gene id: 9601:MAPK9
uniprot id: A0A2J8SCP6
uniprot id: H2PHM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SARDH
gene id: 9601:SARDH
uniprot id: Q5RCY0
names: Similarity
messages: Belongs to the GcvT family.

9601:SPNS1
gene id: 9601:SPNS1
uniprot id: H2NQH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9601:GPR18
gene id: 9601:GPR18
uniprot id: A0A6D2XKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9601:CAND1
gene id: 9601:CAND1
uniprot id: Q5R6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAND family.
messages: Cytoplasm
messages: Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with ERCC6 (By similarity). Interacts with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions are bridged by cullins and strongly inhibits the neddylation of cullins (By similarity).
messages: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity).
messages: Nucleus

9601:LOC100459543
gene id: 9601:LOC100459543
uniprot id: A0A2J8XIC1
uniprot id: H2PS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:LY6G6F
gene id: 9601:LY6G6F
uniprot id: A0A2J8R4N8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ANKRD28
gene id: 9601:ANKRD28
uniprot id: A0A2J8U3X8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ERRFI1
gene id: 9601:ERRFI1
uniprot id: A0A663D9I3
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9601:CTNNAL1
gene id: 9601:CTNNAL1
uniprot id: Q5RC06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vinculin/alpha-catenin family.
messages: Interacts with ARHGEF1.
messages: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
messages: cell cortex
messages: cytoskeleton

9601:LOC100460268
gene id: 9601:LOC100460268
uniprot id: H2PNW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:STAT6
gene id: 9601:STAT6
uniprot id: Q5R5Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9601:CDKN1A
gene id: 9601:CDKN1A
uniprot id: A0A6D2X6A2
names: Similarity
messages: Belongs to the CDI family.

9601:AOX1
gene id: 9601:AOX1
uniprot id: Q5RAF7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9601:COPA
gene id: 9601:COPA
uniprot id: A0A663DAU8
uniprot id: H2N547
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PDK3
gene id: 9601:PDK3
uniprot id: H2PV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9601:PRDM2
gene id: 9601:PRDM2
uniprot id: A0A2J8S8V7
uniprot id: H2N907
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HIF1A
gene id: 9601:HIF1A
uniprot id: Q5R4G1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9601:ADRA1D
gene id: 9601:ADRA1D
uniprot id: H2P1A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9601:SLC25A11
gene id: 9601:SLC25A11
uniprot id: Q5RFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9601:KCNJ4
gene id: 9601:KCNJ4
uniprot id: H2P4D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9601:RPL32
gene id: 9601:RPL32
uniprot id: A0A6D2XH95
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100432881
gene id: 9601:LOC100432881
uniprot id: H2P0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TF
gene id: 9601:TF
uniprot id: Q5R9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9601:PTGER1
gene id: 9601:PTGER1
uniprot id: H2NXT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:UBA3
gene id: 9601:UBA3
uniprot id: A0A2J8SWA0
uniprot id: A0A2J8SWA6
uniprot id: A0A2J8SWA8
uniprot id: A0A8I5UHE0
uniprot id: Q5R4A0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Binding of TP53BP2 to the regulatory subunit NAE1 decreases activity.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
messages: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
messages: Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand (By similarity). Interacts with TBATA (By similarity).
messages: It is uncertain whether Met-1 or Met-22 is the initiator.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CAVIN2
gene id: 9601:CAVIN2
uniprot id: H2P859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9601:SGCE
gene id: 9601:SGCE
uniprot id: A0A2J8WJR2
uniprot id: K7EUT8
uniprot id: Q5RAP2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: N-glycosylated.
messages: Ubiquitinated, leading to its degradation by the proteasome.
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9601:LOC100458830
gene id: 9601:LOC100458830
uniprot id: H2NHE4
names: Similarity
messages: Belongs to the intermediate filament family.

9601:PPP1R11
gene id: 9601:PPP1R11
uniprot id: A0A2J8SJR4
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9601:TMEM9
gene id: 9601:TMEM9
uniprot id: A0A6D2WJQ2
names: Similarity
messages: Belongs to the TMEM9 family.

9601:PRKN
gene id: 9601:PRKN
uniprot id: Q5RBE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBR family. Parkin subfamily.
messages: Mitochondrion
messages: cytosol

9601:F9
gene id: 9601:F9
uniprot id: H2PWY7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:RPE65
gene id: 9601:RPE65
uniprot id: H2N732
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9601:LOC100445489
gene id: 9601:LOC100445489
uniprot id: H2NEG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SAR1B
gene id: 9601:SAR1B
uniprot id: A0A6D2VXR3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9601:PIP4P1
gene id: 9601:PIP4P1
uniprot id: A0A663D6F3
uniprot id: H2NKH7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: phagosome membrane

9601:NT5C3A
gene id: 9601:NT5C3A
uniprot id: A0A2J8UNV6
uniprot id: A0A6D2XP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9601:EHHADH
gene id: 9601:EHHADH
uniprot id: Q5R5M8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with highest increase on Lys-346. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids.
messages: Enzyme activity enhanced by acetylation.
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Monomer.
messages: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (By similarity). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity).
messages: Peroxisome

9601:UBQLN2
gene id: 9601:UBQLN2
uniprot id: A0A6D2XMH3
uniprot id: H2PVT4
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: autophagosome

9601:MS4A10
gene id: 9601:MS4A10
uniprot id: I6L550
names: Similarity
messages: Belongs to the MS4A family.

9601:ZSCAN18
gene id: 9601:ZSCAN18
uniprot id: A0A2J8RQK0
uniprot id: A0A6D2WPJ9
names: Subcellular Location Annotation
messages: Nucleus

9601:RPL21
gene id: 9601:RPL21
uniprot id: A0A6D2XST7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9601:LOC100459718
gene id: 9601:LOC100459718
uniprot id: A0A663D9H3
names: Subcellular Location Annotation
messages: Membrane

9601:LOC100448238
gene id: 9601:LOC100448238
uniprot id: H2N347
names: Subcellular Location Annotation
messages: Membrane

9601:ALB
gene id: 9601:ALB
uniprot id: A0A2J8UTX1
uniprot id: Q5NVH5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRAF5
gene id: 9601:TRAF5
uniprot id: A0A6D2XMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9601:PSMA2
gene id: 9601:PSMA2
uniprot id: H2PMA4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9601:LYPLA1
gene id: 9601:LYPLA1
uniprot id: A0A2J8UN68
uniprot id: Q5RBR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity).
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.
messages: Nucleus membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRAF3IP3
gene id: 9601:TRAF3IP3
uniprot id: A0A2J8V6K5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OSBPL1A
gene id: 9601:OSBPL1A
uniprot id: Q5RDK3
names: Similarity
messages: Belongs to the OSBP family.

9601:SLC7A3
gene id: 9601:SLC7A3
uniprot id: A0A6D2WA03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9601:LMX1B
gene id: 9601:LMX1B
uniprot id: A0A2J8UKE9
uniprot id: A0A2J8UKH7
uniprot id: A0A2J8UKH9
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OSBP2
gene id: 9601:OSBP2
uniprot id: Q5R6N7
names: Similarity
messages: Belongs to the OSBP family.

9601:CLVS1
gene id: 9601:CLVS1
uniprot id: A0A2J8UQY3
uniprot id: Q5RCA6
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to PtdIns(3,5)P2 is not required for localization.
messages: Early endosome membrane
messages: Endosome membrane
messages: Forms a complex with clathrin heavy chain and gamma-adaptin.
messages: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
messages: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9601:MED10
gene id: 9601:MED10
uniprot id: A0A2J8TLZ8
uniprot id: Q5R6P5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPI
gene id: 9601:CENPI
uniprot id: A0A6D2X6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9601:KCTD20
gene id: 9601:KCTD20
uniprot id: H2PIV5
names: Subcellular Location Annotation
messages: Cytoplasm

9601:PSMA4
gene id: 9601:PSMA4
uniprot id: A0A2J8SKD6
uniprot id: A0A2J8SKF8
uniprot id: A0A6D2XQ53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNOT7
gene id: 9601:CNOT7
uniprot id: H2PPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9601:IRF2
gene id: 9601:IRF2
uniprot id: Q5R8L3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:C17H17orf98
gene id: 9601:C17H17orf98
uniprot id: H2NUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9601:DPT
gene id: 9601:DPT
uniprot id: H2N4T8
names: Similarity
messages: Belongs to the dermatopontin family.

9601:ZNF286A
gene id: 9601:ZNF286A
uniprot id: A0A8I5TGP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:ANKRD13A
gene id: 9601:ANKRD13A
uniprot id: H2NIL7
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9601:THAP1
gene id: 9601:THAP1
uniprot id: A0A2J8TNT4
uniprot id: Q5RCE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: PML body
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleoplasm

9601:NUP62
gene id: 9601:NUP62
uniprot id: Q5R9X5
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9601:PFDN1
gene id: 9601:PFDN1
uniprot id: A0A2J8VPF0
uniprot id: Q5RAM7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SERINC3
gene id: 9601:SERINC3
uniprot id: A0A2J8XVY2
uniprot id: Q5R533
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: N-glycosylated.
messages: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSNK1A1
gene id: 9601:CSNK1A1
uniprot id: Q5R4M4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:LOC100446887
gene id: 9601:LOC100446887
uniprot id: A0A2J8TSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SLC22A1
gene id: 9601:SLC22A1
uniprot id: A0A2J8XB37
uniprot id: A0A6D2X4Q5
uniprot id: H2PKS9
names: Caution
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AZIN1
gene id: 9601:AZIN1
uniprot id: A0A2J8UFM0
uniprot id: Q5R7K3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
messages: Monomer. Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1.
messages: Nucleus
messages: Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.

9601:TMEM250
gene id: 9601:TMEM250
uniprot id: A0A2J8RMX5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRUNE1
gene id: 9601:PRUNE1
uniprot id: A0A663D8B1
uniprot id: H2N5X4
names: Caution
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SUPT5H
gene id: 9601:SUPT5H
uniprot id: Q5R405
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).
messages: Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. Also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (By similarity). Interacts with MCM3AP (By similarity).
messages: Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II (By similarity).
messages: Nucleus
messages: Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis (By similarity).

9601:EXOC3
gene id: 9601:EXOC3
uniprot id: Q5R8B9
names: Similarity
messages: Belongs to the SEC6 family.

9601:RNF8
gene id: 9601:RNF8
uniprot id: Q5R4I2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidence is however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm. Interacts with WRAP53/TCAB1.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2 (By similarity). This domain is also required for proper recruitment to DNA damage sites after UV irradiation, ionizing radiation, or treatment with an alkylating agent (By similarity).
messages: telomere

9601:ERG28
gene id: 9601:ERG28
uniprot id: A0A2J8W639
uniprot id: Q5R589
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NIPA2
gene id: 9601:NIPA2
uniprot id: A0A2J8R7N4
uniprot id: Q5R7Q3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a selective Mg(2+) transporter.
messages: Belongs to the NIPA family.
messages: Cell membrane
messages: Early endosome
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CALCOCO2
gene id: 9601:CALCOCO2
uniprot id: Q5R7H1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CALCOCO family.
messages: Dimer. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with MYO6 (By similarity). Interacts with GEMIN4. Interacts with ATG8 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Interacts with ATG8 family member MAP1LC3C. Interacts with LGALS8. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and CALCOCO2 (By similarity). Interacts with AZI2 (By similarity).
messages: The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation.
messages: The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria.
messages: The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation.
messages: The MYO6-binding domain is required for autophagy-mediated degradation of infecting bacteria such as Salmonella typhimurium, but not for bacteria targeting to autophagosomes.
messages: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).
messages: autophagosome membrane
messages: cytoskeleton
messages: perinuclear region

9601:RPS8
gene id: 9601:RPS8
uniprot id: H2N7M3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9601:SLC7A6OS
gene id: 9601:SLC7A6OS
uniprot id: A0A2J8VVA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9601:KAT7
gene id: 9601:KAT7
uniprot id: H2NVL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9601:ZNF571
gene id: 9601:ZNF571
uniprot id: Q5R5Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:KIAA0319
gene id: 9601:KIAA0319
uniprot id: A0A2J8S4P8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HDAC1
gene id: 9601:HDAC1
uniprot id: Q5RAG0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
messages: Nucleus
messages: Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Component of a RCOR/GFI/KDM1A/HDAC complex. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with the non-histone region of MACROH2A1. Interacts with TRIM28; the interaction recruits HDAC1 to E2F1 and inhibits its acetylation. Interacts with SP1; the interaction deacetylates SP1 and regulates its transcriptional activity. Interacts with SP3; the interaction deacetylates SP3 and regulates its transcriptional activity. In vitro, C(18) ceramides increase this interaction and the subsequent SP3 deacetylation and SP3-mediated repression of the TERT promoter. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with C10orf90/FATS (via its N-terminal); the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21. Interacts with CDK5 complexed to CDK5R1 (p25…
messages: Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
messages: Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
messages: Ubiquitinated by CHFR and KCTD11, leading to its degradation by the proteasome.

9601:NTN4
gene id: 9601:NTN4
uniprot id: Q5RB89
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May form a homodimer.
messages: May play an important role in neural, kidney and vascular development.
messages: extracellular matrix

9601:STK19
gene id: 9601:STK19
uniprot id: A0A6D2WC80
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DPPA2
gene id: 9601:DPPA2
uniprot id: H2P9S9
names: Subcellular Location Annotation
messages: Nucleus

9601:TNFRSF11A
gene id: 9601:TNFRSF11A
uniprot id: A0A2J8W3I1
uniprot id: A0A2J8W3I6
uniprot id: A0A2J8W3J0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:TRAPPC3L
gene id: 9601:TRAPPC3L
uniprot id: H2PK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9601:PPFIA2
gene id: 9601:PPFIA2
uniprot id: Q5RBH0
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9601:EDN2
gene id: 9601:EDN2
uniprot id: H2N7T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9601:C12H12orf76
gene id: 9601:C12H12orf76
uniprot id: A0A663D748
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDO1
gene id: 9601:CDO1
uniprot id: A0A2J8XEI8
uniprot id: Q5RBQ7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 Fe cation per subunit. Ni(2+) and Zn(2+) can be used to a lesser extent.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
messages: Monomer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

9601:CD164
gene id: 9601:CD164
uniprot id: A0A2J8U1M6
uniprot id: H2PK04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9601:F12
gene id: 9601:F12
uniprot id: H2PHI3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:TAX1BP1
gene id: 9601:TAX1BP1
uniprot id: A0A2J8VDR1
uniprot id: A0A2J8VDR9
uniprot id: Q5R4U3
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1. Interacts with MAVS; this interaction induces MAVS polyubiquitination. Interacts with TNIP1. Interacts with TRAF6; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation. Interacts with RIPK1; this interaction negatively regulates RIPK1 ubiquitination. Interacts with NBR1. Interacts with TBK1. Interacts with RB1CC1. Interacts with SQSTM1. Interacts with AZI2.
messages: Mitochondrion
messages: Preautophagosomal structure
messages: The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation.
messages: autophagosome

9601:RNFT2
gene id: 9601:RNFT2
uniprot id: Q5RAG4
names: Subcellular Location Annotation
messages: Membrane

9601:SIVA1
gene id: 9601:SIVA1
uniprot id: H2NME4
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9601:MYOC
gene id: 9601:MYOC
uniprot id: H2N4Q4
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Rough endoplasmic reticulum
messages: cilium
messages: extracellular exosome
messages: extracellular matrix

9601:VWF
gene id: 9601:VWF
uniprot id: F5XVC0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9601:CEP57L1
gene id: 9601:CEP57L1
uniprot id: H2PJZ9
names: Similarity
messages: Belongs to the translokin family.

9601:GPX7
gene id: 9601:GPX7
uniprot id: H2N7D8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9601:GPR135
gene id: 9601:GPR135
uniprot id: A0A6D2XK63
names: Caution
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MR1
gene id: 9601:MR1
uniprot id: A0A2J8V7Z4
uniprot id: Q5RD09
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent (By similarity).
messages: Belongs to the MHC class I family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3 (By similarity).
messages: MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells (By similarity).
messages: N-glycosylated.
messages: The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (By similarity).
messages: The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNPPD1
gene id: 9601:CNPPD1
uniprot id: Q5R4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNPPD1 family.
messages: Membrane

9601:ZBTB18
gene id: 9601:ZBTB18
uniprot id: A0A663DH42
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HMBS
gene id: 9601:HMBS
uniprot id: H2NFJ6
names: Similarity
messages: Belongs to the HMBS family.

9601:SNCB
gene id: 9601:SNCB
uniprot id: A0A2J8RDJ1
uniprot id: A0A6D2XEZ5
names: Similarity
messages: Belongs to the synuclein family.

9601:PPDPFL
gene id: 9601:PPDPFL
uniprot id: A0A2J8UMZ6
uniprot id: A0A2J8UN12
uniprot id: H2PQA0
names: Similarity
messages: Belongs to the PPDPF family.

9601:SEMA3G
gene id: 9601:SEMA3G
uniprot id: H2PAJ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:DCPS
gene id: 9601:DCPS
uniprot id: H2NFU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9601:AMACR
gene id: 9601:AMACR
uniprot id: Q5RF52
names: Similarity
messages: Belongs to the CoA-transferase III family.

9601:CDC42SE1
gene id: 9601:CDC42SE1
uniprot id: Q5RDD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA (By similarity).
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity).
messages: The CRIB domain mediates interaction with CDC42.
messages: cytoskeleton

9601:CHRM1
gene id: 9601:CHRM1
uniprot id: Q5R949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
messages: Cell membrane
messages: Interacts with GPRASP2 (By similarity). Interacts with TMEM147 (By similarity).
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9601:NDUFS1
gene id: 9601:NDUFS1
uniprot id: P0CB67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Interacts with MDM2 and AKAP1 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).
messages: Mitochondrion inner membrane

9601:RFESD
gene id: 9601:RFESD
uniprot id: A0A2J8TD83
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TAAR1
gene id: 9601:TAAR1
uniprot id: F7VJP7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:NADK2
gene id: 9601:NADK2
uniprot id: A0A2J8WB52
uniprot id: A0A2J8WB68
uniprot id: Q5RBC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDX21
gene id: 9601:DDX21
uniprot id: H2NAQ5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9601:LOC100460507
gene id: 9601:LOC100460507
uniprot id: A0A6D2XH95
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC15A4
gene id: 9601:SLC15A4
uniprot id: H2NJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9601:SLC10A2
gene id: 9601:SLC10A2
uniprot id: Q5RDE8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9601:RAB39A
gene id: 9601:RAB39A
uniprot id: H2NF68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9601:INTU
gene id: 9601:INTU
uniprot id: H2PEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9601:TTC30B
gene id: 9601:TTC30B
uniprot id: H2P7Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9601:PLBD1
gene id: 9601:PLBD1
uniprot id: H2NGP1
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9601:LOC100451889
gene id: 9601:LOC100451889
uniprot id: H2N351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CAMK4
gene id: 9601:CAMK4
uniprot id: A0A2J8XEQ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:NBR1
gene id: 9601:NBR1
uniprot id: Q5RC94
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
messages: Cytoplasm
messages: Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN, TRIM55, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. Interacts with TAX1BP1 (By similarity).
messages: Lysosome
messages: M line
messages: Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates.
messages: The PB1 domain mediates interaction with SQSTM1.
messages: autophagosome

9601:LOC100437134
gene id: 9601:LOC100437134
uniprot id: A0A6D2XWU0
uniprot id: H2PVS6
names: Caution
names: Similarity
messages: Belongs to the GAGE family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100454469
gene id: 9601:LOC100454469
uniprot id: A0A6D2XJT7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9601:SEC13
gene id: 9601:SEC13
uniprot id: A0A2J8WDG4
uniprot id: A0A2J8WDI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nuclear pore complex

9601:MED30
gene id: 9601:MED30
uniprot id: H2PR26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9601:CSRP2
gene id: 9601:CSRP2
uniprot id: A0A6D2X754
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FUNDC1
gene id: 9601:FUNDC1
uniprot id: H2PVD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9601:LOC100455801
gene id: 9601:LOC100455801
uniprot id: H2ND50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9601:TMSB15B
gene id: 9601:TMSB15B
uniprot id: A0A663DCM1
uniprot id: H2PXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9601:ULK3
gene id: 9601:ULK3
uniprot id: A0A2J8UDC3
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EFNA4
gene id: 9601:EFNA4
uniprot id: H2N5I4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:KEF63 p03
gene id: 9601:KEF63_p03
uniprot id: A0A0G2JSG4
uniprot id: P92699
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9601:UBE2V2
gene id: 9601:UBE2V2
uniprot id: A0A2J8UMY9
uniprot id: Q5R6C9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
messages: Heterodimer with UBE2N. Binds CHFR (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CWF19L1
gene id: 9601:CWF19L1
uniprot id: Q5R8R4
names: Similarity
messages: Belongs to the CWF19 family.

9601:CMTM7
gene id: 9601:CMTM7
uniprot id: A0A2J8WYS1
uniprot id: A0A663D628
names: Subcellular Location Annotation
messages: Membrane

9601:TSPAN33
gene id: 9601:TSPAN33
uniprot id: H2PNH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9601:HHATL
gene id: 9601:HHATL
uniprot id: A0A6D2XRZ6
names: Subcellular Location Annotation
messages: Membrane

9601:RGS8
gene id: 9601:RGS8
uniprot id: A0A2J8V826
uniprot id: A0A663DFF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9601:KLHL28
gene id: 9601:KLHL28
uniprot id: A0A2J8V9L6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FMNL3
gene id: 9601:FMNL3
uniprot id: A0A2J8SYH7
uniprot id: H2NH80
names: Similarity
messages: Belongs to the formin homology family.

9601:ADPGK
gene id: 9601:ADPGK
uniprot id: A0A2J8UCX0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BOD1L2
gene id: 9601:BOD1L2
uniprot id: A0A2J8W356
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: kinetochore

9601:JAK1
gene id: 9601:JAK1
uniprot id: H2N755
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9601:BCAT2
gene id: 9601:BCAT2
uniprot id: Q5REP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (By similarity). May also function as a transporter of branched chain alpha-keto acids (By similarity).
messages: Homodimer.
messages: Mitochondrion

9601:DCTN2
gene id: 9601:DCTN2
uniprot id: A0A2J8UH02
uniprot id: H2NHT8
uniprot id: Q5RF06
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9601:VBP1
gene id: 9601:VBP1
uniprot id: A0A2J8RM70
uniprot id: A0A2J8RM90
uniprot id: Q5RCG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Cytoplasm
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADRB1
gene id: 9601:ADRB1
uniprot id: H2NBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SLC16A13
gene id: 9601:SLC16A13
uniprot id: H2NSG9
names: Subcellular Location Annotation
messages: Membrane

9601:HSPA2
gene id: 9601:HSPA2
uniprot id: A0A6D2W7E6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9601:ATP6V1F
gene id: 9601:ATP6V1F
uniprot id: H2PNG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9601:TRMT112
gene id: 9601:TRMT112
uniprot id: H2PXN9
names: Similarity
messages: Belongs to the TRM112 family.

9601:APLP2
gene id: 9601:APLP2
uniprot id: A0A2J8WZE4
uniprot id: A0A2J8WZE5
uniprot id: A0A8I5T066
uniprot id: H2NFW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FOLH1B
gene id: 9601:FOLH1B
uniprot id: H2NEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9601:SGPL1
gene id: 9601:SGPL1
uniprot id: A0A663DEX8
uniprot id: H2NAM8
uniprot id: Q5R4G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
messages: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer.

9601:TTC26
gene id: 9601:TTC26
uniprot id: A0A663D6I4
uniprot id: H2PNN4
names: Similarity
messages: Belongs to the IFT56 family.

9601:SLC38A1
gene id: 9601:SLC38A1
uniprot id: Q5R443
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Inhibited by alpha-(methylamino)isobutyric acid (MeAIB). Inhibited by lithium, potassium, choline ions, N-methylglucamine. The pH dependence has an allosteric effect on the transport.
messages: N-glycosylation plays an important role in the L-glutamine transport.
messages: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (By similarity).

9601:DYNLL1
gene id: 9601:DYNLL1
uniprot id: A0A6D2WSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9601:NEUROG1
gene id: 9601:NEUROG1
uniprot id: A0A6D2XQU7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRGN
gene id: 9601:SRGN
uniprot id: A0A6D2W5R8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDX23
gene id: 9601:DDX23
uniprot id: Q5RC67
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
messages: Chromosome
messages: In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation. May be phosphorylated by SRPK2 on Ser residues in the SR domain; the phosphorylation is required for the removal of inappropriate R-loops during transcription.
messages: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
messages: Nucleus
messages: The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4. Interacts with ERCC6.

9601:SSTR5
gene id: 9601:SSTR5
uniprot id: H2NPN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TMEM168
gene id: 9601:TMEM168
uniprot id: A0A2J8UPP2
uniprot id: A0A2J8UPP3
uniprot id: Q5RD28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane
messages: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A. May play a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LBX1
gene id: 9601:LBX1
uniprot id: H2NBC9
names: Subcellular Location Annotation
messages: Nucleus

9601:C1H1orf74
gene id: 9601:C1H1orf74
uniprot id: A0A2J8V6J0
uniprot id: Q5REJ0
names: Caution
names: Similarity
messages: Belongs to the UPF0739 family.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTH2R
gene id: 9601:PTH2R
uniprot id: H2P8G3
names: Subcellular Location Annotation
messages: Membrane

9601:ARF6
gene id: 9601:ARF6
uniprot id: H2NL69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9601:KIF22
gene id: 9601:KIF22
uniprot id: A0A2J8TKC0
uniprot id: A0A2J8TKF0
uniprot id: Q5REP4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Interacts with FAM83D and SIAH1.
messages: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
messages: cytoskeleton

9601:CIPC
gene id: 9601:CIPC
uniprot id: Q5R8C5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CLOCK. Forms a ternary complex with the CLOCK-BMAL1 heterodimer (By similarity). Interacts with CAD and HSPA5 (By similarity).
messages: Nucleus
messages: Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock.
messages: cytosol

9601:EXTL2
gene id: 9601:EXTL2
uniprot id: A0A6D2Y6V6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:PLD3
gene id: 9601:PLD3
uniprot id: A0A2J8SDY2
uniprot id: Q5R4Y7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity).
messages: Belongs to the phospholipase D family.
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with APP.
messages: It was initially thought that PDL3 has phospholipase D activity due to its HKD motifs. The second HKD motif contains Glu instead of the canonical Asp. Its enzyme activity is therefore unsure. Catalytic phospholipase D activity is still controversial (By similarity). Its closest homolog PLD4, exhibits no phospholipase activity (By similarity).
messages: Late endosome membrane
messages: Lysosome lumen
messages: N-glycosylated.
messages: Proteolytically processed to a soluble form that is stable within endosomes and lysosomes. During transport through the secretory pathway becomes proteolysed by cysteine proteases, thereby releasing a stable soluble lysosomal lumenal polypeptide, whereas the transmembrane-bound fragment is rapidly degraded. Its transport route to lysosomes involves ubiquitination and the ESCRT complex.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated. Ubiquitination mediates sorting into lysosomes.

9601:TSR2
gene id: 9601:TSR2
uniprot id: A0A2J8RNQ7
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9601:CA3
gene id: 9601:CA3
uniprot id: H2PQQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9601:ZNF75A
gene id: 9601:ZNF75A
uniprot id: H2NPY5
names: Subcellular Location Annotation
messages: Nucleus

9601:ING1
gene id: 9601:ING1
uniprot id: A0A2J8X853
uniprot id: A0A2J8X863
uniprot id: A0A6D2XFY4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LYPD2
gene id: 9601:LYPD2
uniprot id: H2PRB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:KRT7
gene id: 9601:KRT7
uniprot id: H2NHC9
names: Similarity
messages: Belongs to the intermediate filament family.

9601:CD200R1
gene id: 9601:CD200R1
uniprot id: A0A2J8W2R3
uniprot id: A0A6D2XB27
uniprot id: H2P9Q5
names: Similarity
messages: Belongs to the CD200R family.

9601:SOX2
gene id: 9601:SOX2
uniprot id: H2PC44
names: Subcellular Location Annotation
messages: Nucleus

9601:AHCY
gene id: 9601:AHCY
uniprot id: H2P1P8
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9601:MMP7
gene id: 9601:MMP7
uniprot id: H2NF31
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9601:SSR4
gene id: 9601:SSR4
uniprot id: A0A2J8RLK1
uniprot id: A0A8I5TF46
uniprot id: Q5REH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ANAPC16
gene id: 9601:ANAPC16
uniprot id: A0A2J8U5U9
uniprot id: Q5REH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: kinetochore

9601:UBL3
gene id: 9601:UBL3
uniprot id: A0A6D2Y0G1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:USP3
gene id: 9601:USP3
uniprot id: A0A6D2XFE1
uniprot id: H2NNG0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9601:PIAS1
gene id: 9601:PIAS1
uniprot id: A0A2J8UCA9
uniprot id: K7EUN2
names: Similarity
messages: Belongs to the PIAS family.

9601:HSBP1
gene id: 9601:HSBP1
uniprot id: A0A2J8T9T9
uniprot id: Q5RDI2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HSBP1 family.
messages: Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer (By similarity).
messages: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SDR42E1
gene id: 9601:SDR42E1
uniprot id: H2NRL4
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9601:CHTF8
gene id: 9601:CHTF8
uniprot id: A0A6D2W3G3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2H
gene id: 9601:UBE2H
uniprot id: A0A6D2WHF7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:LOC100440345
gene id: 9601:LOC100440345
uniprot id: H2PS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:RFX2
gene id: 9601:RFX2
uniprot id: H2NX71
uniprot id: Q5RDR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RFX family.
messages: Cytoplasm
messages: Homodimer; probably only forms homodimers in testis. Heterodimer; heterodimerizes with RFX1 and RFX3.
messages: Nucleus
messages: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6.

9601:SLC29A3
gene id: 9601:SLC29A3
uniprot id: A0A2J8U5Z7
uniprot id: H2NAM5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALKAL2
gene id: 9601:ALKAL2
uniprot id: H2P730
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9601:ARL6IP4
gene id: 9601:ARL6IP4
uniprot id: A0A2J8XJ82
uniprot id: A0A663D8X2
uniprot id: H2NJ09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:VPS18
gene id: 9601:VPS18
uniprot id: H2NMW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9601:ZNF624
gene id: 9601:ZNF624
uniprot id: H2NSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:DUSP18
gene id: 9601:DUSP18
uniprot id: Q5R8X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: Nucleus

9601:ATP2B2
gene id: 9601:ATP2B2
uniprot id: A0A2J8WDF9
uniprot id: A0A2J8WDH0
uniprot id: A0A6D2WVX8
uniprot id: A0A8I5U906
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PMS1
gene id: 9601:PMS1
uniprot id: Q5R904
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9601:FGFR1OP2
gene id: 9601:FGFR1OP2
uniprot id: A0A2J8WBL4
uniprot id: A0A2J8WBQ2
uniprot id: Q5R561
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm
messages: May be involved in wound healing pathway.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EED
gene id: 9601:EED
uniprot id: A0A2J8S9L3
uniprot id: A0A6D2X3B9
uniprot id: H2NEV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRAP1
gene id: 9601:TRAP1
uniprot id: Q5R6F4
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9601:WARS2
gene id: 9601:WARS2
uniprot id: A0A2J8SQI3
uniprot id: A0A2J8SQI6
uniprot id: A0A663D6B3
names: Caution
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPL38
gene id: 9601:MRPL38
uniprot id: Q5RDL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9601:LOC100457745
gene id: 9601:LOC100457745
uniprot id: A0A6D2VW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:UNC5D
gene id: 9601:UNC5D
uniprot id: A0A2J8X5S4
uniprot id: H2PQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9601:ADH6
gene id: 9601:ADH6
uniprot id: Q5R7Z8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9601:RDH16
gene id: 9601:RDH16
uniprot id: H2NHR7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:FCAMR
gene id: 9601:FCAMR
uniprot id: Q5R770
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM (By similarity).
messages: N-glycosylated.

9601:NEK6
gene id: 9601:NEK6
uniprot id: A0A2J8SFK2
uniprot id: A0A6D2X7T1
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RECQL
gene id: 9601:RECQL
uniprot id: Q5RF63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. RecQ subfamily.
messages: DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
messages: Interacts with EXO1. Interacts with MLH1.
messages: Nucleus

9601:HEY2
gene id: 9601:HEY2
uniprot id: A0A2J8RYZ2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALDH1A2
gene id: 9601:ALDH1A2
uniprot id: A0A2J8VC86
uniprot id: A0A2J8VC94
uniprot id: A0A663DC80
uniprot id: H2NNC7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9601:CRADD
gene id: 9601:CRADD
uniprot id: A0A2J8XN48
uniprot id: Q5R6I4
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
messages: Cytoplasm
messages: Forms a complex named the PIDDosome with PIDD1 and CASP2. Interacts (via Death domain) with RIPK1 (via Death domain); the interaction is direct. Interacts with TRADD. Interacts with TNFRSF1A.
messages: Nucleus
messages: The CARD domain mediates a direct interaction with CASP2.
messages: The Death domain mediates the interaction with PIDD1 and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn probably recruit 7 CASP2 to form the PIDDosome. The Death domain mediates a direct interaction with the Death domain of RIPK1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100460203
gene id: 9601:LOC100460203
uniprot id: A0A2J8TK13
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9601:LANCL3
gene id: 9601:LANCL3
uniprot id: A0A2J8WJ14
uniprot id: A0A6D2W126
names: Similarity
messages: Belongs to the LanC-like protein family.

9601:PDK4
gene id: 9601:PDK4
uniprot id: H2PMV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9601:RRP15
gene id: 9601:RRP15
uniprot id: A0A2J8RS55
uniprot id: A0A6D2XPW2
uniprot id: H2N3P6
names: Caution
names: Similarity
messages: Belongs to the RRP15 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IL4
gene id: 9601:IL4
uniprot id: A0A2J8XDQ2
uniprot id: H2PGI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9601:LOC100453551
gene id: 9601:LOC100453551
uniprot id: A0A6D2XPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9601:NMU
gene id: 9601:NMU
uniprot id: A0A2J8SGN6
uniprot id: H2PDD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9601:C6H6orf89
gene id: 9601:C6H6orf89
uniprot id: A0A2J8Y3M7
uniprot id: I6L5B3
uniprot id: Q5R9Q8
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Homodimer (By similarity). Interacts with BRS3 (By similarity). Interacts (via N-terminus) with SIN3B (By similarity).
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100461968
gene id: 9601:LOC100461968
uniprot id: H2P2Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9601:ALOX15B
gene id: 9601:ALOX15B
uniprot id: H2NSM2
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:C12H12orf45
gene id: 9601:C12H12orf45
uniprot id: A0A6D2WIT2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MMP10
gene id: 9601:MMP10
uniprot id: A0A2J8XX54
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:RRM2
gene id: 9601:RRM2
uniprot id: A0A6D2XY74
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9601:MTMR1
gene id: 9601:MTMR1
uniprot id: A0A2J8S404
uniprot id: H2PX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9601:LOC100452784
gene id: 9601:LOC100452784
uniprot id: H2N8Y0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:GLUD2
gene id: 9601:GLUD2
uniprot id: H2PWN9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9601:SNRPF
gene id: 9601:SNRPF
uniprot id: A0A6D2W2E7
uniprot id: H2NIB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C17H17orf53
gene id: 9601:C17H17orf53
uniprot id: A0A2J8UYB7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZDHHC13
gene id: 9601:ZDHHC13
uniprot id: A0A2J8UQR1
uniprot id: A0A2J8UQV7
uniprot id: Q5NVB9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with HTT. Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:B3GNT4
gene id: 9601:B3GNT4
uniprot id: H2NIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:PRPF31
gene id: 9601:PRPF31
uniprot id: H2P019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9601:GPM6B
gene id: 9601:GPM6B
uniprot id: Q5R5S8
uniprot id: Q5R603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Interacts with SERT.
messages: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake (By similarity).
messages: Membrane

9601:DNAJC28
gene id: 9601:DNAJC28
uniprot id: A0A6D2XPH5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRRG1
gene id: 9601:PRRG1
uniprot id: A0A2J8WIZ9
uniprot id: Q5RCB6
names: Caution
names: PTM
names: Subcellular Location Annotation
messages: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPRASP1
gene id: 9601:GPRASP1
uniprot id: A0A6D2XVX3
names: Similarity
messages: Belongs to the GPRASP family.

9601:IL18RAP
gene id: 9601:IL18RAP
uniprot id: H2P5A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane

9601:CHST9
gene id: 9601:CHST9
uniprot id: H2NW37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane

9601:YPEL1
gene id: 9601:YPEL1
uniprot id: A0A663DAV6
uniprot id: H2P3Q2
names: Caution
names: Similarity
messages: Belongs to the yippee family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:P2RX6
gene id: 9601:P2RX6
uniprot id: A0A2J8RZF8
uniprot id: H2P514
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POLDIP3
gene id: 9601:POLDIP3
uniprot id: A0A663DD98
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ACYP2
gene id: 9601:ACYP2
uniprot id: H2P677
names: Similarity
messages: Belongs to the acylphosphatase family.

9601:STARD5
gene id: 9601:STARD5
uniprot id: Q5R8P9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

9601:SLC37A3
gene id: 9601:SLC37A3
uniprot id: Q5R7V2
names: Subcellular Location Annotation
messages: Membrane

9601:RORC
gene id: 9601:RORC
uniprot id: A0A2J8VFD1
uniprot id: Q5RAP4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Interacts (via AF-2 motif) with the coactivators NCOA1, NCOA2 and PPARGC1A (via LXXLL motif) (By similarity). Interacts with the corepressor NCOR1 (By similarity). Interacts with CRY1 (By similarity). Interacts (via AF-2 motif) with PROX1 (By similarity). Interacts with FOXP3 (By similarity). Interacts with NR0B2 (By similarity).
messages: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1. Essential for thymopoiesis and the development of several secondary lymphoid tissues, inc…
messages: Nucleus
messages: The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2.

9601:GLIS3
gene id: 9601:GLIS3
uniprot id: A0A2J8XHM9
uniprot id: H2PS90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM133A
gene id: 9601:FAM133A
uniprot id: A0A6D2XFZ8
names: Caution
names: Similarity
messages: Belongs to the FAM133 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ENDOU
gene id: 9601:ENDOU
uniprot id: A0A2J8WCV3
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9601:GDAP2
gene id: 9601:GDAP2
uniprot id: H2N672
names: Similarity
messages: Belongs to the GDAP2 family.

9601:SF1
gene id: 9601:SF1
uniprot id: A0A2J8TYS4
uniprot id: A0A2J8TYT7
uniprot id: A0A2J8TYT8
uniprot id: K7ET11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLIN3
gene id: 9601:PLIN3
uniprot id: Q5RAV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the perilipin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain).
messages: Lipid droplet
messages: Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
messages: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

9601:LOC100173781
gene id: 9601:LOC100173781
uniprot id: Q5R5F7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:CBY1
gene id: 9601:CBY1
uniprot id: A0A2J8UWM6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PAGE4
gene id: 9601:PAGE4
uniprot id: A0A6D2XYI3
names: Similarity
messages: Belongs to the GAGE family.

9601:ZNF26
gene id: 9601:ZNF26
uniprot id: A0A2J8RAS9
uniprot id: H2NJ83
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100448477
gene id: 9601:LOC100448477
uniprot id: H2PL28
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane

9601:PNMT
gene id: 9601:PNMT
uniprot id: H2NU97
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9601:SFRP4
gene id: 9601:SFRP4
uniprot id: H2PMC2
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MEIS2
gene id: 9601:MEIS2
uniprot id: Q5RFK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9601:STAC2
gene id: 9601:STAC2
uniprot id: H2NUB0
names: Subcellular Location Annotation
messages: sarcolemma

9601:ZNF280A
gene id: 9601:ZNF280A
uniprot id: H2P3Q8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9601:FEN1
gene id: 9601:FEN1
uniprot id: A0A6D2XQ94
uniprot id: H2ND72
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9601:SGMS2
gene id: 9601:SGMS2
uniprot id: A0A6D2WA16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9601:ZNF160
gene id: 9601:ZNF160
uniprot id: A0A6D2Y2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LOC100443308
gene id: 9601:LOC100443308
uniprot id: A0A6D2XLU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:EIF2B2
gene id: 9601:EIF2B2
uniprot id: H2NLT4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9601:ZNF146
gene id: 9601:ZNF146
uniprot id: A0A2J8RS26
uniprot id: Q5RFP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NAP1L2
gene id: 9601:NAP1L2
uniprot id: H2PW14
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9601:NMUR2
gene id: 9601:NMUR2
uniprot id: A0A2J8X6G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PGLYRP4
gene id: 9601:PGLYRP4
uniprot id: H2N5P9
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9601:NXPH3
gene id: 9601:NXPH3
uniprot id: A0A2J8W8X9
uniprot id: A0A663DGQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC48A1
gene id: 9601:SLC48A1
uniprot id: A0A2J8WCU8
uniprot id: A0A2J8WCW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9601:INSL4
gene id: 9601:INSL4
uniprot id: H2PS80
names: Subcellular Location Annotation
messages: Secreted

9601:CD55
gene id: 9601:CD55
uniprot id: A0A2J8V6N0
uniprot id: A0A2J8V6N1
uniprot id: A0A2J8V6N2
uniprot id: A0A2J8V6N5
uniprot id: A0A663DGJ6
uniprot id: H2N3V8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BHMT2
gene id: 9601:BHMT2
uniprot id: A0A2J8VT02
uniprot id: K7EV30
uniprot id: Q5RF32
names: Caution
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.
messages: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SMIM15
gene id: 9601:SMIM15
uniprot id: A0A2J8V5H4
uniprot id: Q5R4D8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSNK1G1
gene id: 9601:CSNK1G1
uniprot id: A0A2J8T893
uniprot id: A0A2J8T8C5
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:YES1
gene id: 9601:YES1
uniprot id: Q5REC4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9601:C3AR1
gene id: 9601:C3AR1
uniprot id: H2NGE3
uniprot id: Q5REI5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21 (By similarity).
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9601:LOC100431591
gene id: 9601:LOC100431591
uniprot id: H2NU69
names: Similarity
messages: Belongs to the intermediate filament family.

9601:SLC22A9
gene id: 9601:SLC22A9
uniprot id: H2ND26
names: Subcellular Location Annotation
messages: Membrane

9601:E2F2
gene id: 9601:E2F2
uniprot id: H2N8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9601:TRIM45
gene id: 9601:TRIM45
uniprot id: H2N678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9601:RHBDD1
gene id: 9601:RHBDD1
uniprot id: H2P8S7
uniprot id: Q5RBS4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by aprotinin.
messages: Interacts with BIK and STEAP3. Interacts (via C-terminal domain) with VCP. Interacts with ubiquitin and ubiquitinated proteins (By similarity).
messages: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia (By similarity).
messages: Membrane
messages: Mitochondrion membrane
messages: One study reported that the protein is not localized in the mitochondrion.

9601:IZUMO1
gene id: 9601:IZUMO1
uniprot id: A0A2J8U7P2
names: Caution
names: Similarity
messages: Belongs to the Izumo family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NPPA
gene id: 9601:NPPA
uniprot id: H2N930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9601:LAMP3
gene id: 9601:LAMP3
uniprot id: A0A6D2WWB2
uniprot id: H2PC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9601:TTC3
gene id: 9601:TTC3
uniprot id: A0A6D2XDK7
names: Subcellular Location Annotation
messages: Cytoplasm

9601:SORBS2
gene id: 9601:SORBS2
uniprot id: Q5RCI7
names: Subcellular Location Annotation
messages: focal adhesion

9601:RMDN1
gene id: 9601:RMDN1
uniprot id: Q5R8E4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMDN family.
messages: Cytoplasm
messages: Interacts with microtubules.
messages: spindle
messages: spindle pole

9601:SLC44A4
gene id: 9601:SLC44A4
uniprot id: Q5RFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9601:LMNB1
gene id: 9601:LMNB1
uniprot id: H2PGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9601:LOC100438362
gene id: 9601:LOC100438362
uniprot id: H2PI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:MYOZ2
gene id: 9601:MYOZ2
uniprot id: A0A2J8XPU8
uniprot id: Q5R6I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myozenin family.
messages: Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA (By similarity).
messages: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Z line

9601:FAM222B
gene id: 9601:FAM222B
uniprot id: A0A2J8TMU0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC103888628
gene id: 9601:LOC103888628
uniprot id: K7ET60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:TRAPPC1
gene id: 9601:TRAPPC1
uniprot id: H2NSL9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9601:TMEM89
gene id: 9601:TMEM89
uniprot id: A0A663DHU2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TDRD3
gene id: 9601:TDRD3
uniprot id: A0A2J8SGF1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC39A14
gene id: 9601:SLC39A14
uniprot id: A0A2J8X4M8
names: Subcellular Location Annotation
messages: Membrane

9601:NAT9
gene id: 9601:NAT9
uniprot id: H2NUM7
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9601:DYNLRB1
gene id: 9601:DYNLRB1
uniprot id: H2P1Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9601:HARS2
gene id: 9601:HARS2
uniprot id: A0A2J8VP90
uniprot id: Q5R5E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.
messages: Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POSTN
gene id: 9601:POSTN
uniprot id: A0A2J8R645
uniprot id: A0A2J8R649
uniprot id: A0A2J8R654
uniprot id: A0A2J8R669
uniprot id: A0A2J8R674
uniprot id: H2NJN7
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular matrix

9601:ALG11
gene id: 9601:ALG11
uniprot id: Q5R7Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain (By similarity).

9601:ADGRG3
gene id: 9601:ADGRG3
uniprot id: H2NR14
names: Subcellular Location Annotation
messages: Membrane

9601:FASTK
gene id: 9601:FASTK
uniprot id: A0A2J8RKA9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITGA4
gene id: 9601:ITGA4
uniprot id: H2P811
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9601:LOC100451363
gene id: 9601:LOC100451363
uniprot id: H2PRF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9601:RCAN2
gene id: 9601:RCAN2
uniprot id: A0A2J8Y4Z0
uniprot id: Q5RE25
names: Caution
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C22H22orf39
gene id: 9601:C22H22orf39
uniprot id: Q5RE30
names: Similarity
messages: Belongs to the UPF0545 family.

9601:CASR
gene id: 9601:CASR
uniprot id: A0A2J8W258
uniprot id: A0A6D2W642
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GABARAP
gene id: 9601:GABARAP
uniprot id: H2NSH8
names: Similarity
messages: Belongs to the ATG8 family.

9601:DOK2
gene id: 9601:DOK2
uniprot id: H2PPQ3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9601:POLR2K
gene id: 9601:POLR2K
uniprot id: H2PQX3
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9601:HSD17B10
gene id: 9601:HSD17B10
uniprot id: H2PVQ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:CHFR
gene id: 9601:CHFR
uniprot id: Q5RF77
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated; may regulate its cellular level.
messages: Belongs to the CHFR family.
messages: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
messages: Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).
messages: PML body
messages: Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.
messages: Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.
messages: The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins.
messages: The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint.

9601:POPDC3
gene id: 9601:POPDC3
uniprot id: H2PJX8
names: Similarity
messages: Belongs to the popeye family.

9601:NEK9
gene id: 9601:NEK9
uniprot id: A0A663DEJ9
uniprot id: H2NLU1
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITM2B
gene id: 9601:ITM2B
uniprot id: A0A2J8VSH4
uniprot id: Q5R876
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity).
messages: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.
messages: Membrane
messages: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).
messages: Secreted
messages: The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DUSP12
gene id: 9601:DUSP12
uniprot id: A0A2J8SLD8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TVP23B
gene id: 9601:TVP23B
uniprot id: A0A2J8TFB8
uniprot id: Q5R9I4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNX16
gene id: 9601:SNX16
uniprot id: Q5R6Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer. Interacts with EGFR (By similarity).
messages: Late endosome membrane
messages: Lysosome
messages: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity).
messages: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

9601:FCGR2A
gene id: 9601:FCGR2A
uniprot id: A0A2J8SLH8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MRPS26
gene id: 9601:MRPS26
uniprot id: H2P1D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9601:REPIN1
gene id: 9601:REPIN1
uniprot id: A0A2J8RK03
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GABRG1
gene id: 9601:GABRG1
uniprot id: Q5RA86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:LAMTOR4
gene id: 9601:LAMTOR4
uniprot id: A0A2J8RUS4
uniprot id: Q5R483
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).
messages: Belongs to the LAMTOR4 family.
messages: Lysosome
messages: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GMPR
gene id: 9601:GMPR
uniprot id: Q5RCX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9601:TAX1BP3
gene id: 9601:TAX1BP3
uniprot id: A0A6D2VTI0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9601:BTG3
gene id: 9601:BTG3
uniprot id: A0A6D2Y658
names: Similarity
messages: Belongs to the BTG family.

9601:SRPX2
gene id: 9601:SRPX2
uniprot id: H2PW85
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9601:SLC52A2
gene id: 9601:SLC52A2
uniprot id: A0A2J8RHQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DMAC2
gene id: 9601:DMAC2
uniprot id: A0A2J8SEE0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PITX3
gene id: 9601:PITX3
uniprot id: A0A2J8XYH8
uniprot id: A0A6D2WP48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PADI1
gene id: 9601:PADI1
uniprot id: H2N8V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9601:BORA
gene id: 9601:BORA
uniprot id: A0A2J8WU16
uniprot id: A0A663D6N0
uniprot id: H2NK15
names: Caution
names: Similarity
messages: Belongs to the BORA family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SDHAF3
gene id: 9601:SDHAF3
uniprot id: H2PMV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9601:TINAGL1
gene id: 9601:TINAGL1
uniprot id: H2N875
names: Similarity
messages: Belongs to the peptidase C1 family.

9601:PPIC
gene id: 9601:PPIC
uniprot id: A0A6D2Y610
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9601:CAMSAP2
gene id: 9601:CAMSAP2
uniprot id: A0A2J8UXR9
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9601:CBLB
gene id: 9601:CBLB
uniprot id: A0A8I5UD86
uniprot id: H2P9U4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9601:MMP1
gene id: 9601:MMP1
uniprot id: H2NF34
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:EVA1B
gene id: 9601:EVA1B
uniprot id: A0A6D2XK47
names: Similarity
messages: Belongs to the EVA1 family.

9601:GLUL
gene id: 9601:GLUL
uniprot id: A0A2J8V806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9601:LOC100460680
gene id: 9601:LOC100460680
uniprot id: H2NKI9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9601:DEPDC7
gene id: 9601:DEPDC7
uniprot id: Q5R8B7
names: Similarity
messages: Belongs to the DEPDC7 family.

9601:ATP5PF
gene id: 9601:ATP5PF
uniprot id: A0A2J8UKI1
uniprot id: Q5RBY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM205C
gene id: 9601:FAM205C
uniprot id: A0A2J8T0Q0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TFAP2B
gene id: 9601:TFAP2B
uniprot id: A0A2J8SQ39
names: Similarity
messages: Belongs to the AP-2 family.

9601:HPX
gene id: 9601:HPX
uniprot id: A0A2J8SVQ0
uniprot id: Q5R543
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted
messages: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AOC2
gene id: 9601:AOC2
uniprot id: H2NTY3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9601:MUL1
gene id: 9601:MUL1
uniprot id: H2N8R4
names: Subcellular Location Annotation
messages: Membrane

9601:ZSCAN23
gene id: 9601:ZSCAN23
uniprot id: A0A663DAK7
uniprot id: H2PIA9
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM86A
gene id: 9601:TMEM86A
uniprot id: H2NDX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9601:TMX3
gene id: 9601:TMX3
uniprot id: Q5R875
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

9601:KLC2
gene id: 9601:KLC2
uniprot id: A0A6D2XR14
uniprot id: Q5RBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9601:CDC42EP4
gene id: 9601:CDC42EP4
uniprot id: H2NUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9601:HMGCL
gene id: 9601:HMGCL
uniprot id: Q5R9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
messages: Mitochondrion matrix
messages: Peroxisome

9601:PPP2CA
gene id: 9601:PPP2CA
uniprot id: A0A8I5TZJ0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9601:KLHL22
gene id: 9601:KLHL22
uniprot id: H2P3P2
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

9601:FBXL12
gene id: 9601:FBXL12
uniprot id: A0A2J8S1E0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OPRPN
gene id: 9601:OPRPN
uniprot id: H2PDI2
names: Subcellular Location Annotation
messages: Secreted

9601:MPP5
gene id: 9601:MPP5
uniprot id: Q5RDQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: Golgi apparatus
messages: Heterodimer with MPP1 (By similarity). Forms a heterotrimeric complex composed of PALS1, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Component of a complex composed of PALS1, CRB1 and MPP4 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (By similarity). Component of a complex composed of PALS1, CRB1 and EPB41L5. Within the complex, interacts (via HOOK domain) with EPB41L5 (via FERM domain), and interacts with CRB1 (via intracellular domain) (By similarity). Component of a complex composed of PALS1, MPP3 and CRB1; PALS1 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (By similarity). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via PDZ domain) with PATJ (via N-terminus). Interacts with EZR (By similarity). Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (By similarity). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (By similarity). Interacts with WWTR1/TAZ (via WW domain) (By similarity). Interacts with MPP7 (By similarity). Interacts (via PDZ domain) with CRB3 (via C-terminus) (By similarity). Interacts with LIN7C. Interacts with MPDZ. Interacts with PARD6B. Interacts with SC6A1. Interacts with CDH5; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (By similarity). Interacts with NPHP1 (via coiled coil and SH3 domains) (By similarity). Interacts with NPHP4 (By similarity). Interacts with CRB2 (By similarity).
messages: Perikaryon
messages: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
messages: The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.
messages: The PDZ domain binds to the C-terminus of SC6A1.
messages: adherens junction
messages: axon
messages: tight junction

9601:EIF1AX
gene id: 9601:EIF1AX
uniprot id: A0A2J8W418
uniprot id: Q5RA42
names: Caution
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRPC1
gene id: 9601:TRPC1
uniprot id: A0A6D2XDW3
uniprot id: K7EV44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9601:TAC4
gene id: 9601:TAC4
uniprot id: H2NVL3
names: Similarity
messages: Belongs to the tachykinin family.

9601:KCNK9
gene id: 9601:KCNK9
uniprot id: A0A2J8SB11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9601:BICD1
gene id: 9601:BICD1
uniprot id: A0A2J8WC76
uniprot id: H2NGX9
names: Similarity
messages: Belongs to the BicD family.

9601:PKP4
gene id: 9601:PKP4
uniprot id: A0A2J8SUJ0
uniprot id: H2P7L5
names: Caution
names: Similarity
messages: Belongs to the beta-catenin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KRT16
gene id: 9601:KRT16
uniprot id: H2NU30
names: Similarity
messages: Belongs to the intermediate filament family.

9601:AKAP8L
gene id: 9601:AKAP8L
uniprot id: K7ET78
names: Similarity
messages: Belongs to the AKAP95 family.

9601:CXHXorf56
gene id: 9601:CXHXorf56
uniprot id: A0A2J8WWB8
uniprot id: Q5RAT0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STEEP1 family.
messages: Cytoplasm
messages: Interacts with STING1, PIK3C3, and ATG14; the STING1/STEEP1 interaction is increased upon STING1 cGAMP-activation and leads to recruitment of PI3K complex I.
messages: Nucleus
messages: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2D3
gene id: 9601:UBE2D3
uniprot id: A0A2J8XQN5
uniprot id: H2PE07
uniprot id: Q5R4V7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cell membrane
messages: Endosome membrane
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).
messages: Phosphorylated by AURKB.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IFNA21
gene id: 9601:IFNA21
uniprot id: A0A7R8C305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:WDR5B
gene id: 9601:WDR5B
uniprot id: A0A2J8W1X3
uniprot id: Q5RE95
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat WDR5/wds family.
messages: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
messages: Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HIBADH
gene id: 9601:HIBADH
uniprot id: A0A2J8VDR4
uniprot id: Q5R5E7
uniprot id: Q5RF30
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
messages: Homodimer.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDX24
gene id: 9601:DDX24
uniprot id: A0A2J8TLR2
uniprot id: Q5RDL2
names: Caution
names: Function
names: Similarity
messages: ATP-dependent RNA helicase.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP2C1
gene id: 9601:ATP2C1
uniprot id: A0A8I5TSH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9601:MOB1A
gene id: 9601:MOB1A
uniprot id: A0A2J8XBG8
uniprot id: Q5RAE0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).
messages: Belongs to the MOB1/phocein family.
messages: Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2 (By similarity).
messages: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GLB1
gene id: 9601:GLB1
uniprot id: A0A2J8WYP3
uniprot id: A0A2J8WYR5
uniprot id: Q5R7P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
messages: Homodimer. May form higher multimers.
messages: Lysosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTR
gene id: 9601:MTR
uniprot id: Q5R872
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.

9601:GFM2
gene id: 9601:GFM2
uniprot id: Q5R600
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

9601:PLA2G15
gene id: 9601:PLA2G15
uniprot id: H2NRA8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9601:OSBPL3
gene id: 9601:OSBPL3
uniprot id: H2PMM2
names: Similarity
messages: Belongs to the OSBP family.

9601:NDRG3
gene id: 9601:NDRG3
uniprot id: A0A2J8VJL4
uniprot id: Q5RA95
names: Caution
names: Similarity
messages: Belongs to the NDRG family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC18A2
gene id: 9601:SLC18A2
uniprot id: H2NBR1
names: Subcellular Location Annotation
messages: Membrane

9601:WFDC5
gene id: 9601:WFDC5
uniprot id: A0A2J8XVV6
uniprot id: A4K2V3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Putative acid-stable proteinase inhibitor.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNK10
gene id: 9601:KCNK10
uniprot id: A0A663D9J3
uniprot id: K7ESZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9601:BLOC1S3
gene id: 9601:BLOC1S3
uniprot id: A0A6D2XZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

9601:RSBN1L
gene id: 9601:RSBN1L
uniprot id: H2PN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9601:HYPM
gene id: 9601:HYPM
uniprot id: A0A6D2WJ65
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPIN3
gene id: 9601:SPIN3
uniprot id: Q5RAW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPIN/STSY family.
messages: Exhibits H3K4me3-binding activity.
messages: Interacts with C11orf84/SPINDOC.

9601:CTSV
gene id: 9601:CTSV
uniprot id: A0A6D2WFE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9601:NFYA
gene id: 9601:NFYA
uniprot id: A0A2J8Y3Z8
uniprot id: A0A663DBW0
uniprot id: H2PIZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ASTE1
gene id: 9601:ASTE1
uniprot id: A0A2J8U3Q5
uniprot id: Q5RCY5
names: Caution
names: Function
names: Similarity
messages: Belongs to the asteroid family.
messages: Possible role in EGF receptor signaling.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TNFSF18
gene id: 9601:TNFSF18
uniprot id: A0A2J8UBU7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TOMM20L
gene id: 9601:TOMM20L
uniprot id: H2NLD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:CFP
gene id: 9601:CFP
uniprot id: A0A2J8WIG1
uniprot id: Q5RBP8
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A positive regulator of the alternate pathway of complement (By similarity). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity).
messages: In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20 (By similarity). Interacts with the pro-C3-convertase enzyme complex (C3b-Bb) comprised of Complement C3 beta chain (C3b) and the Complement factor B Bb fragment (Bb), where it binds (via its TSP type-1 5 domain) with C3b and Bb (By similarity). This interaction stabilizes the complex and allows it to become the active C3-convertase enzyme complex (C3b-Bb-FP) (By similarity). Interacts with C3b (By similarity). Interacts with CFB (By similarity).
messages: Secreted
messages: TSP type-1 domain 0 binds to TSP type-1 domain 4, and TSP type-1 domain 1 binds to TSP type-1 domain 6 (By similarity). These interactions mediate multimerization (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ANG
gene id: 9601:ANG
uniprot id: A0A663DFA9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9601:GOT1L1
gene id: 9601:GOT1L1
uniprot id: H2PQ23
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9601:GREM2
gene id: 9601:GREM2
uniprot id: H2N3A5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:LOC100432322
gene id: 9601:LOC100432322
uniprot id: H2N5R9
names: Similarity
messages: Belongs to the LCE family.

9601:KIF1C
gene id: 9601:KIF1C
uniprot id: Q5REL9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9601:BAG6
gene id: 9601:BAG6
uniprot id: A0A2J8R4R3
uniprot id: A0A6D2WV56
uniprot id: A0A8I5YS45
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: extracellular exosome

9601:GK
gene id: 9601:GK
uniprot id: A0A2J8WJ38
uniprot id: A0A2J8WJ49
uniprot id: A0A2J8WJ64
uniprot id: Q5R8P2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CD93
gene id: 9601:CD93
uniprot id: H2P168
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:PRLHR
gene id: 9601:PRLHR
uniprot id: A0A6D2XSA3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:BMI1
gene id: 9601:BMI1
uniprot id: Q5R8L2
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex. Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2. Interacts with RNF2/RING2 (By similarity). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. Interacts with CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Interacts with PHC2 (By similarity). Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.
messages: Cytoplasm
messages: Down-regulated by oxidative stress.
messages: May be polyubiquitinated; which does not lead to proteasomal degradation. Monoubiquitinated.
messages: Nucleus

9601:ZNF584
gene id: 9601:ZNF584
uniprot id: A0A2J8RQH5
uniprot id: A0A6D2W7K9
uniprot id: H2P0H0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:QTRT2
gene id: 9601:QTRT2
uniprot id: Q5R998
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9601:SAYSD1
gene id: 9601:SAYSD1
uniprot id: A0A6D2YAA7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCTD19
gene id: 9601:KCTD19
uniprot id: A0A663D9P5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AGTRAP
gene id: 9601:AGTRAP
uniprot id: A0A2J8USK2
uniprot id: Q5RER2
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity (By similarity).
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with RACK1, and with the carboxy-terminal region of AGTR1.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CENPW
gene id: 9601:CENPW
uniprot id: A0A2J8RZ21
uniprot id: A0A6D2WZU3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MCM2
gene id: 9601:MCM2
uniprot id: H2P9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9601:LOC100448808
gene id: 9601:LOC100448808
uniprot id: A0A663DGJ0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTP4A1
gene id: 9601:PTP4A1
uniprot id: Q5R7J8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
messages: Homotrimer. Interacts with ATF5 and tubulin (By similarity).
messages: Inhibited by sodium orthovanadate and pentamidine.
messages: Nucleus
messages: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
messages: spindle

9601:IKBKB
gene id: 9601:IKBKB
uniprot id: A0A663D575
uniprot id: H2PQ71
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TSNAX
gene id: 9601:TSNAX
uniprot id: Q5RC21
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).
messages: Belongs to the translin family.
messages: Golgi apparatus
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).
messages: Sumoylated with SUMO1.
messages: perinuclear region

9601:PGAM1
gene id: 9601:PGAM1
uniprot id: Q5RFB8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme (By similarity).
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
messages: Homodimer.

9601:LOC100457330
gene id: 9601:LOC100457330
uniprot id: A0A2J8SK36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:KRT37
gene id: 9601:KRT37
uniprot id: A0A6D2XK39
uniprot id: H2NU38
names: Caution
names: Similarity
messages: Belongs to the intermediate filament family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CYSLTR2
gene id: 9601:CYSLTR2
uniprot id: A0A6D2W574
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:PHF19
gene id: 9601:PHF19
uniprot id: A0A2J8WRH8
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRH
gene id: 9601:TRH
uniprot id: H2P9C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9601:PRKAB2
gene id: 9601:PRKAB2
uniprot id: H2N637
uniprot id: Q5RCL6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9601:ZFYVE19
gene id: 9601:ZFYVE19
uniprot id: A0A2J8S617
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MOB3C
gene id: 9601:MOB3C
uniprot id: A0A2J8SLG7
uniprot id: A0A6D2VYX6
names: Caution
names: Similarity
messages: Belongs to the MOB1/phocein family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100433361
gene id: 9601:LOC100433361
uniprot id: A0A663D936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:DHRS7
gene id: 9601:DHRS7
uniprot id: A0A6D2W8R7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:RGR
gene id: 9601:RGR
uniprot id: A0A2J8XW55
uniprot id: H2NAE2
names: Subcellular Location Annotation
messages: Membrane

9601:IL18R1
gene id: 9601:IL18R1
uniprot id: A0A6D2Y601
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9601:SLC9A5
gene id: 9601:SLC9A5
uniprot id: H2NR71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9601:PLEKHJ1
gene id: 9601:PLEKHJ1
uniprot id: A0A2J8R3S7
uniprot id: A0A6D2YB06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: clathrin-coated vesicle
messages: trans-Golgi network

9601:RBBP8
gene id: 9601:RBBP8
uniprot id: Q5R5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9601:CCL16
gene id: 9601:CCL16
uniprot id: H2NTE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:HOOK1
gene id: 9601:HOOK1
uniprot id: H2N782
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9601:DCP1A
gene id: 9601:DCP1A
uniprot id: H2PAH6
names: Similarity
messages: Belongs to the DCP1 family.

9601:NR0B1
gene id: 9601:NR0B1
uniprot id: H2PV75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9601:IFT22
gene id: 9601:IFT22
uniprot id: A0A2J8XUF6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DUPD1
gene id: 9601:DUPD1
uniprot id: H2NAI0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9601:CEP85
gene id: 9601:CEP85
uniprot id: A0A2J8SIK7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EPHA3
gene id: 9601:EPHA3
uniprot id: H2PA12
names: Subcellular Location Annotation
messages: Membrane

9601:CALCRL
gene id: 9601:CALCRL
uniprot id: Q5RCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9601:SSTR4
gene id: 9601:SSTR4
uniprot id: H2P166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:DPY19L2
gene id: 9601:DPY19L2
uniprot id: H2PMD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9601:ZNF432
gene id: 9601:ZNF432
uniprot id: A0A6D2WU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:ACVR1
gene id: 9601:ACVR1
uniprot id: A0A6D2WS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9601:CETP
gene id: 9601:CETP
uniprot id: A0A2J8VYX5
uniprot id: H2NQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.
messages: Secreted

9601:NR2E1
gene id: 9601:NR2E1
uniprot id: H2PJZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9601:UBA52
gene id: 9601:UBA52
uniprot id: A0A6D2VZN3
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9601:SPRR1B
gene id: 9601:SPRR1B
uniprot id: A0A2J8VFI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9601:LOC100435754
gene id: 9601:LOC100435754
uniprot id: H2PI51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:SULT4A1
gene id: 9601:SULT4A1
uniprot id: Q5R4X3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9601:SNX11
gene id: 9601:SNX11
uniprot id: A0A6D2WI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9601:ZSCAN16
gene id: 9601:ZSCAN16
uniprot id: H2PI99
names: Subcellular Location Annotation
messages: Nucleus

9601:METAP1
gene id: 9601:METAP1
uniprot id: A0A2J8TQQ3
uniprot id: Q5RBF3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit of the 80S translational complex.
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTIF2
gene id: 9601:MTIF2
uniprot id: H2P668
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9601:ZDHHC21
gene id: 9601:ZDHHC21
uniprot id: Q5RB84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: cis-Golgi network membrane

9601:LOC103891389
gene id: 9601:LOC103891389
uniprot id: H2N5R3
names: Similarity
messages: Belongs to the LCE family.

9601:CAPN1
gene id: 9601:CAPN1
uniprot id: A0A6D2XIF5
uniprot id: Q5NVS7
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 4 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7).
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with a small (regulatory) subunit CAPNS1.
messages: Membrane
messages: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity).

9601:FABP1
gene id: 9601:FABP1
uniprot id: Q5RDP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9601:DDX3Y
gene id: 9601:DDX3Y
uniprot id: Q5RF43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: May interact with TDRD3.
messages: Nucleus
messages: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (By similarity).

9601:CLN3
gene id: 9601:CLN3
uniprot id: A0A6D2XMZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9601:EME1
gene id: 9601:EME1
uniprot id: A0A2J8W8R6
uniprot id: Q5NVA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EME1/MMS4 family.
messages: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
messages: May self-associate. Interacts with MUS81.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:SMIM8
gene id: 9601:SMIM8
uniprot id: A0A2J8VRK8
uniprot id: Q5REX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ALDOA
gene id: 9601:ALDOA
uniprot id: A0A6D2X493
uniprot id: Q5NVR5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (By similarity). In addition, may also function as scaffolding protein (By similarity).
messages: Homotetramer. Interacts with SNX9 and WAS. Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+) (By similarity).
messages: I band
messages: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
messages: M line
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FTHL17
gene id: 9601:FTHL17
uniprot id: H2PV81
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9601:MAT2B
gene id: 9601:MAT2B
uniprot id: A0A2J8X738
uniprot id: Q5R4E0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DLX1
gene id: 9601:DLX1
uniprot id: A0A6D2WBH7
names: Subcellular Location Annotation
messages: Nucleus

9601:TAS2R40
gene id: 9601:TAS2R40
uniprot id: H2PNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9601:FZD2
gene id: 9601:FZD2
uniprot id: H2NTT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:RAB7A
gene id: 9601:RAB7A
uniprot id: Q5R9Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle
messages: Endosome membrane
messages: Interacts with NTRK1/TRKA (By similarity). Interacts with RILP (By similarity). Interacts with PSMA7 (By similarity). Interacts with RNF115 (By similarity). Interacts with FYCO1 (By similarity). Interacts with the PIK3C3/VPS34-PIK3R4 complex (By similarity). The GTP-bound form interacts with OSBPL1A (By similarity). The GTP-bound form interacts with RAC1 (By similarity). Interacts with CLN3 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with C9orf72. Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5 (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with RUFY4 (By similarity). Interacts with PRPH; the interaction is direct (By similarity). Interacts with VPS13A (By similarity). The GDP-bound form interacts with RIMOC1 (By similarity). Interacts with the MON1A-CCZ1B complex and this interaction is enhanced in the presence of RIMOC1 (By similarity).
messages: Late endosome membrane
messages: Lipid droplet
messages: Lysosome membrane
messages: Melanosome membrane
messages: Mitochondrion membrane
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By s…
messages: autophagosome membrane
messages: phagosome membrane

9601:EIF2AK3
gene id: 9601:EIF2AK3
uniprot id: H2P5J0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9601:TMEM80
gene id: 9601:TMEM80
uniprot id: H2NCB4
names: Subcellular Location Annotation
messages: Membrane

9601:MAGED2
gene id: 9601:MAGED2
uniprot id: A0A2J8RNS3
uniprot id: Q5RFC2
names: Caution
names: Function
names: Subunit
messages: Interacts with GNAS.
messages: Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF613
gene id: 9601:ZNF613
uniprot id: A0A2J8U9H0
uniprot id: A0A663DD80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TBX20
gene id: 9601:TBX20
uniprot id: H2PMD8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9601:SLAMF7
gene id: 9601:SLAMF7
uniprot id: A0A2J8VHN2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLD2
gene id: 9601:PLD2
uniprot id: A0A6D2XVP9
names: Similarity
messages: Belongs to the phospholipase D family.

9601:NIM1K
gene id: 9601:NIM1K
uniprot id: A0A6D2XV59
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:H3F3B
gene id: 9601:H3F3B
uniprot id: Q5RCC9
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed throughout the cell cycle independently of DNA synthesis.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity).
messages: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9601:COG1
gene id: 9601:COG1
uniprot id: H2NUK4
names: Similarity
messages: Belongs to the COG1 family.

9601:SSFA2
gene id: 9601:SSFA2
uniprot id: Q5REU9
names: Subcellular Location Annotation
messages: Cytoplasm

9601:GOLPH3L
gene id: 9601:GOLPH3L
uniprot id: H2N5Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9601:PGLS
gene id: 9601:PGLS
uniprot id: A0A2J8T6C2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSGALNACT2
gene id: 9601:CSGALNACT2
uniprot id: H2NA74
uniprot id: Q5R9J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9601:ECHS1
gene id: 9601:ECHS1
uniprot id: Q5R646
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond. Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (By similarity). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation. At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity).
messages: Homohexamer; dimer of trimers.
messages: Mitochondrion matrix

9601:RANBP1
gene id: 9601:RANBP1
uniprot id: A0A2J8RBS5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TIMM13
gene id: 9601:TIMM13
uniprot id: H2NWX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9601:SSX2IP
gene id: 9601:SSX2IP
uniprot id: A0A2J8WQH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: adherens junction
messages: centriolar satellite

9601:AMT
gene id: 9601:AMT
uniprot id: H2PAR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9601:GNG12
gene id: 9601:GNG12
uniprot id: A0A2J8WPT7
uniprot id: Q5RBQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHYH
gene id: 9601:PHYH
uniprot id: A0A2J8VKH5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100436687
gene id: 9601:LOC100436687
uniprot id: H2NH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:FGF12
gene id: 9601:FGF12
uniprot id: Q5R8V8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9601:GSTO2
gene id: 9601:GSTO2
uniprot id: A0A663DH52
uniprot id: H2NBJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TEX28
gene id: 9601:TEX28
uniprot id: A0A2J8RLS9
uniprot id: A0A6D2WKP6
names: Caution
names: Similarity
messages: Belongs to the TEX28 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HSD17B3
gene id: 9601:HSD17B3
uniprot id: A0A2J8WNL6
uniprot id: H2PST1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:ZNF337
gene id: 9601:ZNF337
uniprot id: H2P196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:SLC39A8
gene id: 9601:SLC39A8
uniprot id: Q5RDE2
names: Subcellular Location Annotation
messages: Membrane

9601:RNF14
gene id: 9601:RNF14
uniprot id: A0A2J8VNZ4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EVX1
gene id: 9601:EVX1
uniprot id: H2PMJ7
names: Subcellular Location Annotation
messages: Nucleus

9601:UBXN4
gene id: 9601:UBXN4
uniprot id: A0A2J8TET4
uniprot id: Q5R4I3
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.
messages: Endoplasmic reticulum membrane
messages: Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
messages: Nucleus envelope
messages: The UBX domain is required for interaction with VCP.
messages: The intramembrane domain also contains the signal for ER targeting.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CNOT4
gene id: 9601:CNOT4
uniprot id: A0A2J8V3K7
uniprot id: A0A2J8V3R2
uniprot id: A0A6D2WX75
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100432451
gene id: 9601:LOC100432451
uniprot id: A0A2J8V925
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9601:CHID1
gene id: 9601:CHID1
uniprot id: A0A2J8XS00
uniprot id: Q5RFF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Interacts with STAB1.
messages: Lysosome
messages: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TRIM16
gene id: 9601:TRIM16
uniprot id: Q5R760
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinates via its B-Boxes.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
messages: Homodimerizes via its coiled-coil domain. Heterodimerizes with MID1, TRIM24 and PML. Interacts with Galectin-3/LGALS3 in a ULK1-dependent manner; this interaction mediates autophagy of damage endomembranes. Interacts with BECN1. Interacts with ATG16L1. Interacts with p62/SQSTM and LC3B/MAP1LC3B.
messages: Phosphorylated by ULK1.

9601:NPEPPS
gene id: 9601:NPEPPS
uniprot id: A0A663D815
uniprot id: H2NVF4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:XBP1
gene id: 9601:XBP1
uniprot id: A0A663D8N5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSMD7
gene id: 9601:PSMD7
uniprot id: H2PXQ1
names: Similarity
messages: Belongs to the peptidase M67A family.

9601:RGS9BP
gene id: 9601:RGS9BP
uniprot id: H2NYB5
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9601:E2F3
gene id: 9601:E2F3
uniprot id: A0A2J8WND3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM208
gene id: 9601:TMEM208
uniprot id: A0A6D2W9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9601:NSF
gene id: 9601:NSF
uniprot id: A0A2J8UZ34
uniprot id: Q5R410
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity).
messages: Phosphorylation at Ser-569 interferes with homohexamerization.
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GSX1
gene id: 9601:GSX1
uniprot id: H2NJH6
names: Subcellular Location Annotation
messages: Nucleus

9601:ATP1B2
gene id: 9601:ATP1B2
uniprot id: H2NSL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9601:ATAD2
gene id: 9601:ATAD2
uniprot id: Q5RDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Interaction with ESR1 and NCOA3 is enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).
messages: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).
messages: Nucleus

9601:NUDT5
gene id: 9601:NUDT5
uniprot id: A0A2J8VKD9
uniprot id: A0A2J8VKE2
uniprot id: A0A6D2WJS7
uniprot id: Q5RCY2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
messages: Homodimer. Interacts with PARG.
messages: Nucleus
messages: Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF664
gene id: 9601:ZNF664
uniprot id: Q5RAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:LOC100190801
gene id: 9601:LOC100190801
uniprot id: A0A2J8SQS4
uniprot id: Q5RCS7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9601:LOC100439237
gene id: 9601:LOC100439237
uniprot id: H2NVF2
names: Similarity
messages: Belongs to the GroES chaperonin family.

9601:HABP2
gene id: 9601:HABP2
uniprot id: A0A2J8W721
uniprot id: H2NBM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STAM
gene id: 9601:STAM
uniprot id: H2N9W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9601:CCR7
gene id: 9601:CCR7
uniprot id: A0A2J8WAD8
names: Caution
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NAPEPLD
gene id: 9601:NAPEPLD
uniprot id: A0A6D2X279
uniprot id: Q5RCU3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by divalent cations. Activated by bile acids.
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (By similarity). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity).
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope
messages: Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
messages: nucleoplasm

9601:METTL4
gene id: 9601:METTL4
uniprot id: A0A2J8XGL9
uniprot id: H2NVY7
names: Similarity
messages: Belongs to the MT-A70-like family.

9601:FTSJ3
gene id: 9601:FTSJ3
uniprot id: A0A2J8UZK7
uniprot id: Q5RAS1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Citrullinated by PADI4.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:ADSSL1
gene id: 9601:ADSSL1
uniprot id: H2NME3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9601:EIF4EBP3
gene id: 9601:EIF4EBP3
uniprot id: A0A8I5YMQ7
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9601:NAPG
gene id: 9601:NAPG
uniprot id: Q5R642
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9601:CFAP65
gene id: 9601:CFAP65
uniprot id: A0A2J8TU81
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NSFL1C
gene id: 9601:NSFL1C
uniprot id: A0A2J8VI76
uniprot id: A0A2J8VI81
uniprot id: Q5RBG3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSFL1C family.
messages: Chromosome
messages: Golgi stack
messages: Nucleus
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP (By similarity).
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.
messages: Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity).
messages: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome

9601:FBL
gene id: 9601:FBL
uniprot id: H2NYT9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9601:FAM126B
gene id: 9601:FAM126B
uniprot id: A0A2J8WV60
uniprot id: Q5R977
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM126 family.
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
messages: Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2).
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:MFSD14B
gene id: 9601:MFSD14B
uniprot id: H2PSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9601:PDE6D
gene id: 9601:PDE6D
uniprot id: A0A6D2Y8A3
uniprot id: H2P8W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9601:CLEC12B
gene id: 9601:CLEC12B
uniprot id: A0A2J8RGP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:MCTS1
gene id: 9601:MCTS1
uniprot id: A0A2J8WWG4
uniprot id: H2PWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9601:FUZ
gene id: 9601:FUZ
uniprot id: A0A2J8U8F3
uniprot id: H2NZP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9601:CASS4
gene id: 9601:CASS4
uniprot id: A0A2J8TXL4
uniprot id: H2P2C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9601:AKAP12
gene id: 9601:AKAP12
uniprot id: H2PKM5
names: Subcellular Location Annotation
messages: Membrane

9601:RPS3A
gene id: 9601:RPS3A
uniprot id: Q5R5K0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

9601:UFSP2
gene id: 9601:UFSP2
uniprot id: Q5RCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C78 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts with DDRGK1. Interacts with TRIP4; deufmylates TRIP4.
messages: Nucleus
messages: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.

9601:DPH1
gene id: 9601:DPH1
uniprot id: H2NS67
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9601:CASP6
gene id: 9601:CASP6
uniprot id: A0A6D2YB20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9601:DAZAP2
gene id: 9601:DAZAP2
uniprot id: Q5R526
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Following DNA damage, phosphorylated by HIPK2 which promotes DAZAP2 localization to the nucleus, reduces interaction of DAZAP2 with HIPK2 and SIAH1, and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent HIPK2 proteasomal degradation.
messages: In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation (By similarity).
messages: Interacts with SOX6. Interacts with DAZ1 and DAZL. Interacts with IL17RB. May interact with FAM168B. Interacts with INCA1. Interacts with EIF4G1 and EIF4G2 (By similarity). Interacts (via PPAY motif) with NEDD4 (via WW domains) (By similarity). Interacts with transcription factor TCF4; the interaction results in localization of DAZAP2 to the nucleus (By similarity). Interacts with transcription factors TCF7 and TCF7L1 (By similarity). Interacts with transcription factor LEF1 (By similarity). Interacts with serine/threonine-protein kinase HIPK2; the interaction results in phosphorylation of DAZAP2 which causes localization of DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent degradation of HIPK2 (By similarity). Interacts with ubiquitin ligase SIAH1; the interaction is decreased following phosphorylation of DAZAP2 by HIPK2 (By similarity). Interacts with TP53; the interaction is triggered by DNA damage (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Stress granule
messages: Ubiquitinated by SMURF2, leading to proteasomal degradation. Ubiquitinated by NEDD4, leading to proteasomal degradation.
messages: nuclear body

9601:PNP
gene id: 9601:PNP
uniprot id: A0A2J8TT03
uniprot id: A0A6D2XZB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DPP4
gene id: 9601:DPP4
uniprot id: H2P7N3
uniprot id: Q5R7G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9601:TOLLIP
gene id: 9601:TOLLIP
uniprot id: A0A663DAJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9601:MIOX
gene id: 9601:MIOX
uniprot id: A0A2J8XTH4
uniprot id: A0A2J8XTJ7
uniprot id: Q5REY9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLSTN3
gene id: 9601:CLSTN3
uniprot id: Q5R9Q9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds synaptic Ca(2+) with its cytoplasmic domain.
messages: Cell membrane
messages: Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. Interacts with low affinity with KLC1 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
messages: Postsynapse
messages: Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-beta chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with gamma-secretase (By similarity).
messages: dendrite

9601:USP9X
gene id: 9601:USP9X
uniprot id: A0A6D2WJD7
uniprot id: H2PVC1
names: Caution
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RTCA
gene id: 9601:RTCA
uniprot id: A0A2J8VCL0
uniprot id: Q5R7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Monomer.
messages: nucleoplasm

9601:BRMS1L
gene id: 9601:BRMS1L
uniprot id: H2NL16
names: Subcellular Location Annotation
messages: Nucleus

9601:USP10
gene id: 9601:USP10
uniprot id: H2NRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9601:RALY
gene id: 9601:RALY
uniprot id: A0A2J8VIX1
uniprot id: H2P1P5
names: Caution
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HECTD2
gene id: 9601:HECTD2
uniprot id: Q5RD78
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9601:LYRM2
gene id: 9601:LYRM2
uniprot id: A0A2J8VRT9
uniprot id: Q5RES3
names: Caution
names: Similarity
messages: Belongs to the complex I LYR family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NKAIN1
gene id: 9601:NKAIN1
uniprot id: H2N882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9601:LOC100294628
gene id: 9601:LOC100294628
uniprot id: A0A6D2WT58
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDX18
gene id: 9601:DDX18
uniprot id: Q5R7S3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9601:DNAJB14
gene id: 9601:DNAJB14
uniprot id: Q5R6H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts (via J domain) with HSPA8/Hsc70. Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct.
messages: Nucleus membrane

9601:UBE2U
gene id: 9601:UBE2U
uniprot id: H2N759
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:CCT8
gene id: 9601:CCT8
uniprot id: A0A2J8UKM0
uniprot id: Q5RAP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: cilium basal body

9601:RAD50
gene id: 9601:RAD50
uniprot id: H2PGI2
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9601:BLOC1S1
gene id: 9601:BLOC1S1
uniprot id: Q5R7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S1 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts with ATP5F1A and NDUFA9; involved in their acetylation on lysine residues. Interacts with KXD1.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: cytosol

9601:LOC100447767
gene id: 9601:LOC100447767
uniprot id: A0A0M6L0G5
uniprot id: A0A1B1R0V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9601:TPP1
gene id: 9601:TPP1
uniprot id: Q5RFL1
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity).
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
messages: Lysosome
messages: Melanosome
messages: Monomer. Interacts with CLN5. Interacts with CLN3 (By similarity).

9601:IPMK
gene id: 9601:IPMK
uniprot id: H2NAV3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9601:EDC4
gene id: 9601:EDC4
uniprot id: H2NR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9601:TIPRL
gene id: 9601:TIPRL
uniprot id: A0A2J8SAS1
uniprot id: H2N4U4
names: Similarity
messages: Belongs to the TIP41 family.

9601:SERPINE1
gene id: 9601:SERPINE1
uniprot id: H2PLR6
names: Similarity
messages: Belongs to the serpin family.

9601:SPDYC
gene id: 9601:SPDYC
uniprot id: H2NCX0
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9601:LOC100458051
gene id: 9601:LOC100458051
uniprot id: H2PIK6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9601:NR3C1
gene id: 9601:NR3C1
uniprot id: Q5R9P5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1 and TGFB1I1. Interacts with NCOA1. Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1. Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation. Interacts with GSK3B. Interacts with FNIP1 and FNIP2. Interacts (via C-terminus) with HNRNPU (via C-terminus). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Increased proteasome-mediated degradation in response to glucocorticoids.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Phosphorylation at Ser-211 increases transcriptional activity. Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity. Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
messages: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
messages: Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity. Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.
messages: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
messages: centrosome
messages: spindle

9601:ABCD3
gene id: 9601:ABCD3
uniprot id: A0A2J8VCS8
uniprot id: A0A2J8VCT2
uniprot id: Q5RCT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDRGK1
gene id: 9601:DDRGK1
uniprot id: A0A6D2WQC7
names: Similarity
messages: Belongs to the DDRGK1 family.

9601:ROCK2
gene id: 9601:ROCK2
uniprot id: H2P6Y3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

9601:ADH1A
gene id: 9601:ADH1A
uniprot id: Q5RBP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alcohol dehydrogenase. Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate.
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Dimer of identical or heterodimer of closely related subunits alpha, beta, or gamma that are encoded by genes ADH1A, ADH1B, and ADH1C, respectively.

9601:PARP6
gene id: 9601:PARP6
uniprot id: Q5RDU4
names: Function
names: PTM
names: Similarity
messages: Auto-mono-ADP-ribosylated.
messages: Belongs to the ARTD/PARP family.
messages: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

9601:IFNA8
gene id: 9601:IFNA8
uniprot id: H2PS16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:WNT11
gene id: 9601:WNT11
uniprot id: H2NEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9601:GPD1
gene id: 9601:GPD1
uniprot id: A0A2J8SY75
uniprot id: A0A2J8SY97
uniprot id: Q5RCE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Has glycerol-3-phosphate dehydrogenase activity.
messages: Homodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PDLIM1
gene id: 9601:PDLIM1
uniprot id: H2NB36
names: Subcellular Location Annotation
messages: Z line

9601:ARHGEF6
gene id: 9601:ARHGEF6
uniprot id: A0A2J8WX91
names: Caution
names: Subcellular Location Annotation
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: lamellipodium

9601:TMUB2
gene id: 9601:TMUB2
uniprot id: A0A6D2YCB8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FLVCR1
gene id: 9601:FLVCR1
uniprot id: H2N3R4
names: Subcellular Location Annotation
messages: Membrane

9601:HMGN2
gene id: 9601:HMGN2
uniprot id: Q5RAA0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation favors cytoplasmic localization.

9601:MGAT1
gene id: 9601:MGAT1
uniprot id: H2PHN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9601:LOC100435169
gene id: 9601:LOC100435169
uniprot id: A0A6D2WFG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:CSNK1A1L
gene id: 9601:CSNK1A1L
uniprot id: A0A6D2WZC3
uniprot id: H2NJN6
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100442522
gene id: 9601:LOC100442522
uniprot id: A0A2J8S4W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:PPM1K
gene id: 9601:PPM1K
uniprot id: A0A2J8V5E7
uniprot id: Q5R522
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Mitochondrion matrix
messages: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SEC11C
gene id: 9601:SEC11C
uniprot id: A0A2J8W3A2
uniprot id: Q5RC30
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SPCS2 and SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: May undergo processing at the N-terminus.
messages: Membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAT2A
gene id: 9601:MAT2A
uniprot id: A0A2J8RP92
uniprot id: Q5R5H1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPCS1
gene id: 9601:SPCS1
uniprot id: A0A2J8THP1
uniprot id: Q5RF96
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SPCS2 and SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: May be phosphorylated.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TIMM50
gene id: 9601:TIMM50
uniprot id: Q5RAJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.
messages: Mitochondrion inner membrane

9601:MOB4
gene id: 9601:MOB4
uniprot id: A0A8I5T5X8
uniprot id: Q5RDB1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOB1/phocein family.
messages: Binds STRN, STRN3 and STRN4. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase (By similarity). Interacts with CTTNBP2 and CTTNBP2NL (By similarity).
messages: Golgi stack membrane
messages: May play a role in membrane trafficking, specifically in membrane budding reactions.
messages: Membrane
messages: Phosphorylated on serine residues.
messages: perinuclear region

9601:SMIM22
gene id: 9601:SMIM22
uniprot id: A0A2J8S732
uniprot id: A0A2J8S736
uniprot id: A0A2J8S743
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:METTL1
gene id: 9601:METTL1
uniprot id: H2NHV3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.

9601:MCM4
gene id: 9601:MCM4
uniprot id: H2PQ96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9601:MAX
gene id: 9601:MAX
uniprot id: A0A663DH96
uniprot id: H2NLJ2
names: Similarity
messages: Belongs to the MAX family.

9601:SEPT7
gene id: 9601:SEPT7
uniprot id: A0A2J8UNQ2
uniprot id: Q5R481
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Coordinated expression with SEPTIN2 and SEPTIN6.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPTIN6, while interaction with SEPTIN2 seems indirect. In the absence of SEPTIN6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPTIN2, SEPTIN6 and SEPTIN7. Interacts with SEPTIN5, SEPTIN8, SEPTIN9 and SEPTIN11. Component of a septin core octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the SEPTIN12:SEPTIN7 association is mediated by the respective GTP-binding domains (By similarity).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9601:TMEM87A
gene id: 9601:TMEM87A
uniprot id: A0A2J8S5R3
uniprot id: A0A8I5TL25
uniprot id: H2NMZ2
names: Subcellular Location Annotation
messages: Membrane

9601:GJB1
gene id: 9601:GJB1
uniprot id: A0A2J8UBJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:CAV1
gene id: 9601:CAV1
uniprot id: A0A2J8UPG7
uniprot id: A0A2J8UPH1
uniprot id: Q2IBD7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9601:BTN3A3
gene id: 9601:BTN3A3
uniprot id: Q5R996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9601:P4HA1
gene id: 9601:P4HA1
uniprot id: A0A2J8U5R6
uniprot id: Q5RAG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P4HA family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen
messages: Heterotetramer of two alpha-1 chains and two beta chains (P4HB)(the beta chain is the multi-functional PDI), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPL22L1
gene id: 9601:RPL22L1
uniprot id: A0A2J8TIH8
uniprot id: H2PXN4
names: Caution
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RPA3
gene id: 9601:RPA3
uniprot id: A0A6D2WNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9601:SIX1
gene id: 9601:SIX1
uniprot id: H2NLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9601:HAO1
gene id: 9601:HAO1
uniprot id: H2P104
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9601:FMO4
gene id: 9601:FMO4
uniprot id: Q5R7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:PAGE1
gene id: 9601:PAGE1
uniprot id: A0A2J8S2M6
names: Caution
names: Similarity
messages: Belongs to the GAGE family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC20A2
gene id: 9601:SLC20A2
uniprot id: A0A6D2XG98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9601:IP6K2
gene id: 9601:IP6K2
uniprot id: H2PAT7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9601:FUT10
gene id: 9601:FUT10
uniprot id: H2PQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9601:C18H18orf32
gene id: 9601:C18H18orf32
uniprot id: A0A8I5UB50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9601:GCA
gene id: 9601:GCA
uniprot id: A0A2J8T532
uniprot id: Q5RAI6
names: Caution
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions (By similarity).
messages: Cytoplasm
messages: Cytoplasmic granule membrane
messages: Homodimer. Interacts with SRI and LCP1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This protein has been shown to bind calcium with high affinity.

9601:CPXM1
gene id: 9601:CPXM1
uniprot id: H2P1E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9601:CLCC1
gene id: 9601:CLCC1
uniprot id: H2N6J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9601:PLPP5
gene id: 9601:PLPP5
uniprot id: A0A2J8TP88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FOXL2
gene id: 9601:FOXL2
uniprot id: H2PBK4
names: Subcellular Location Annotation
messages: Nucleus

9601:CDS1
gene id: 9601:CDS1
uniprot id: Q5R9Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9601:LOC100436682
gene id: 9601:LOC100436682
uniprot id: H2NDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TAS2R7
gene id: 9601:TAS2R7
uniprot id: H2NGJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9601:PGAP3
gene id: 9601:PGAP3
uniprot id: A0A2J8W9Y2
uniprot id: H2NU96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9601:LYRM9
gene id: 9601:LYRM9
uniprot id: A0A2J8TMD5
uniprot id: A0A6D2WPC2
names: Caution
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAAH2
gene id: 9601:FAAH2
uniprot id: H2PVT9
names: Similarity
messages: Belongs to the amidase family.

9601:STEAP3
gene id: 9601:STEAP3
uniprot id: A0A2J8VM94
uniprot id: A0A6D2X2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9601:ADM
gene id: 9601:ADM
uniprot id: A0A6D2Y967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9601:MED22
gene id: 9601:MED22
uniprot id: A0A2J8UJ11
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLA2R1
gene id: 9601:PLA2R1
uniprot id: Q5R880
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
messages: Cell membrane
messages: Interacts with sPLA2-IB/PLA2G1B; this interaction mediates intracellular signaling as well as clearance of extracellular sPLA2-IB/PLA2G1B via endocytotic pathway (By similarity). Interacts with sPLA2-X/PLA2G10; this interaction mediates sPLA2-X/PLA2G10 clearance and inactivation (By similarity).
messages: Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10 (By similarity).
messages: Secreted
messages: The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
messages: The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing (By similarity).

9601:LOC103893004
gene id: 9601:LOC103893004
uniprot id: K7ETD3
names: Similarity
messages: Belongs to the serpin family.

9601:APRT
gene id: 9601:APRT
uniprot id: H2NRS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9601:ST14
gene id: 9601:ST14
uniprot id: H2NFW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:UCP1
gene id: 9601:UCP1
uniprot id: H2PED2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9601:SF3A1
gene id: 9601:SF3A1
uniprot id: H2P414
names: Subcellular Location Annotation
messages: Nucleus

9601:WNT10B
gene id: 9601:WNT10B
uniprot id: A0A2J8SYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9601:BMP15
gene id: 9601:BMP15
uniprot id: H2PVN4
names: Similarity
messages: Belongs to the TGF-beta family.

9601:TLCD2
gene id: 9601:TLCD2
uniprot id: A0A663D5M6
names: Subcellular Location Annotation
messages: Membrane

9601:CTU1
gene id: 9601:CTU1
uniprot id: H2NZV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9601:LOC100439753
gene id: 9601:LOC100439753
uniprot id: H2NBG5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:SHPRH
gene id: 9601:SHPRH
uniprot id: A0A6D2WJH6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MPC2
gene id: 9601:MPC2
uniprot id: Q5R4Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Mitochondrion inner membrane
messages: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

9601:LGALSL
gene id: 9601:LGALSL
uniprot id: A0A2J8XC49
uniprot id: Q5R5K6
names: Caution
names: Function
names: Subunit
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Monomer.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CETN2
gene id: 9601:CETN2
uniprot id: H2PX40
names: Similarity
messages: Belongs to the centrin family.

9601:GJA1
gene id: 9601:GJA1
uniprot id: H2PK80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:ATP4B
gene id: 9601:ATP4B
uniprot id: H2NKE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9601:AVPR1A
gene id: 9601:AVPR1A
uniprot id: H2NHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9601:RDH5
gene id: 9601:RDH5
uniprot id: H2NHM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9601:CUTA
gene id: 9601:CUTA
uniprot id: A0A2J8Y333
uniprot id: A0A2J8Y367
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDK2
gene id: 9601:CDK2
uniprot id: H2NHM8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:NPY1R
gene id: 9601:NPY1R
uniprot id: H2PEN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GDPD2
gene id: 9601:GDPD2
uniprot id: A0A2J8UBF3
uniprot id: H2PVX6
names: Caution
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100436122
gene id: 9601:LOC100436122
uniprot id: H2PI50
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:TIAF1
gene id: 9601:TIAF1
uniprot id: A0A2J8TMX7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RETREG2
gene id: 9601:RETREG2
uniprot id: A0A663DE48
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM225B
gene id: 9601:TMEM225B
uniprot id: A0A8I5UBV6
names: Subcellular Location Annotation
messages: Membrane

9601:TM2D2
gene id: 9601:TM2D2
uniprot id: A0A2J8TNZ5
uniprot id: Q5RCC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NXPE4
gene id: 9601:NXPE4
uniprot id: A0A2J8X1J3
uniprot id: H2NFD2
names: Caution
names: Similarity
messages: Belongs to the NXPE family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PHKA1
gene id: 9601:PHKA1
uniprot id: A0A2J8R871
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:USP48
gene id: 9601:USP48
uniprot id: K7EVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9601:FCF1
gene id: 9601:FCF1
uniprot id: A0A2J8T3Z6
uniprot id: Q5RFQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:HBA1
gene id: 9601:HBA1
uniprot id: Q5R9M5
names: Similarity
messages: Belongs to the globin family.

9601:UCK2
gene id: 9601:UCK2
uniprot id: H2N4X0
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9601:FES
gene id: 9601:FES
uniprot id: A0A2J8VXC7
uniprot id: A0A2J8VXE5
uniprot id: A0A6D2WXY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:SOCS6
gene id: 9601:SOCS6
uniprot id: A0A2J8W3U1
uniprot id: Q5RCM6
names: Caution
names: Domain
names: Function
names: Subunit
messages: Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with KIT (phosphorylated). Interacts with PIM3 (By similarity).
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HTR6
gene id: 9601:HTR6
uniprot id: H2N8S6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:PPIH
gene id: 9601:PPIH
uniprot id: A0A663DGR8
uniprot id: H2N7S1
names: Caution
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF346
gene id: 9601:ZNF346
uniprot id: A0A2J8RDN3
uniprot id: Q5R4W8
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.
messages: Cytoplasm
messages: Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
messages: nucleolus

9601:HADHA
gene id: 9601:HADHA
uniprot id: Q5R910
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9601:ZNF549
gene id: 9601:ZNF549
uniprot id: Q5RBQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:RETREG3
gene id: 9601:RETREG3
uniprot id: H2NTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9601:NETO1
gene id: 9601:NETO1
uniprot id: A0A6D2VZ16
uniprot id: H2NWK0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MS4A13
gene id: 9601:MS4A13
uniprot id: A0A8I5YRS5
names: Similarity
messages: Belongs to the MS4A family.

9601:PRKAA1
gene id: 9601:PRKAA1
uniprot id: A0A2J8WBH7
uniprot id: Q5RDH5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylati…
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK (By similarity). Dephosphorylated by PPM1A and PPM1B (By similarity).
messages: The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
messages: Ubiquitinated.

9601:KEF63 p04
gene id: 9601:KEF63_p04
uniprot id: A0A110B1Z2
uniprot id: P92698
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9601:SART3
gene id: 9601:SART3
uniprot id: H2NIJ0
uniprot id: Q5REG1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cajal body
messages: Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2. Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3. Interacts with USP15; the interaction is direct.
messages: Cytoplasm
messages: Nucleus speckle
messages: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair. May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC.
messages: nucleoplasm

9601:NHLRC3
gene id: 9601:NHLRC3
uniprot id: Q5R9V0
names: Subcellular Location Annotation
messages: Secreted

9601:KEAP1
gene id: 9601:KEAP1
uniprot id: A0A6D2VZM8
uniprot id: Q5R774
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated by the BCR(KEAP1) complex. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.
messages: Belongs to the KEAP1 family.
messages: Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1. Interacts with NFE2L2/NRF2; the interaction is direct (By similarity). Forms a ternary complex with NFE2L2/NRF2 and PGAM5 (By similarity). Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation (By similarity). Interacts with NFE2L1. Interacts with BPTF and PTMA. Interacts with MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2. Interacts with HSP90AA1 and HSP90AB1 (By similarity).
messages: Cytoplasm
messages: Degraded via a proteasomal-independent process during selective autophagy: interaction with phosphorylated SQSTM1/p62 sequesters KEAP1 in inclusion bodies, leading to its degradation.
messages: KEAP1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins.
messages: Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex. Accumulation of fumarate promotes the formation of cysteine S-succination (S-(2-succinyl)cysteine), leading to inactivate the BCR(KEAP1) complex and promote NFE2L2/NRF2 nuclear accumulation and activation. Nitric oxide-dependent 8-Nitro-cGMP formation promotes cysteine guanylation (S-cGMP-cysteine), leading to NFE2L2/NRF2 nuclear accumulation and activation. Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates cysteines, activating NFE2L2/NRF2 (By similarity). Methylglyoxal, a reactive metabolite that accumulates when the glycolytic enzyme PGK1 is inhibited, promotes formation of a methylimidazole cross-link between proximal Cys-151 and Arg-135 on another KEAP1 molecule, resulting in an inactive dimer that inactivates the BCR(KEAP1) complex (By similarity).
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
messages: The Kelch repeats mediate interaction with NFE2L2/NRF2, BPTF and PGAM5.
messages: Ubiquitin ligase activity of the BCR(KEAP1) complex is inhibited by oxidative stress and electrophile metabolites such as sulforaphane. Electrophile metabolites react with reactive cysteine residues in KEAP1 and trigger non-enzymatic covalent modifications of these cysteine residues, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex. Selective autophagy also inactivates the BCR(KEAP1) complex via interaction between KEAP1 and SQSTM1/p62, which sequesters the complex in inclusion bodies and promotes its degradation.

9601:COPE
gene id: 9601:COPE
uniprot id: A0A2J8T5Q4
uniprot id: Q5RFR8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: Phosphorylated by PKA.
messages: Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PGM1
gene id: 9601:PGM1
uniprot id: K7EU15
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9601:FTH1
gene id: 9601:FTH1
uniprot id: A0A2J8SMJ6
uniprot id: Q5R8J7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PNLIPRP3
gene id: 9601:PNLIPRP3
uniprot id: H2NBQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9601:CHMP1A
gene id: 9601:CHMP1A
uniprot id: A0A2J8RV94
uniprot id: Q5R605
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane
messages: Nucleus matrix
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity).
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1 (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CCNL2
gene id: 9601:CCNL2
uniprot id: A0A6D2XPM6
uniprot id: H2N9H6
names: Caution
names: Similarity
messages: Belongs to the cyclin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FBXW9
gene id: 9601:FBXW9
uniprot id: A0A663DFL6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ITGA10
gene id: 9601:ITGA10
uniprot id: H2N626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9601:TMEM35B
gene id: 9601:TMEM35B
uniprot id: K7ET47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9601:SIRT2
gene id: 9601:SIRT2
uniprot id: Q5RBF1
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300; acetylation leads both to the decreased of SIRT2-mediated alpha-tubulin deacetylase activity and SIRT2-mediated down-regulation of TP53 transcriptional activity.
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cell projection
messages: Chromosome
messages: Cytoplasm
messages: Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Inhibited by a macrocyclic peptide inhibitor S2iL5. Inhibited by EP300-induced acetylation (By similarity).
messages: Interacts with CDC20, FOXO3 and FZR1 (By similarity). Associates with microtubules in primary cortical mature neurons (By similarity). Homotrimer. Interacts (via both phosphorylated, unphosphorylated, active or inactive forms) with HDAC6; the interaction is necessary for the complex to interact with alpha-tubulin, suggesting that these proteins belong to a large complex that deacetylates the cytoskeleton. Interacts with FOXO1; the interaction is disrupted upon serum-starvation or oxidative stress, leading to increased level of acetylated FOXO1 and induction of autophagy (By similarity). Interacts with RELA; the interaction occurs in the cytoplasm and is increased in a TNF-alpha-dependent manner. Interacts with HOXA10; the interaction is direct. Interacts with YWHAB and YWHAG; the interactions occur in a AKT-dependent manner and increase SIRT2-dependent TP53 deacetylation. Interacts with MAPK1/ERK2 and MAPK3/ERK1; the interactions increase SIRT2 stability and deacetylation activity. Interacts (phosphorylated form) with KMT5A isoform 2; the interaction is direct, stimulates KMT5A-mediated methyltransferase activity on histone at 'Lys-20' (H4K20me1) and is increased in a H(2)O(2)-induced oxidative stress-dependent manner. Interacts with G6PD; the interaction is enhanced by H(2)O(2) treatment. Interacts with a G1/S-specific cyclin E-CDK2 complex. Interacts with AURKA, CDK5R1 (p35 form) and CDK5 and HIF1A. Interacts with the tRNA ligase SARS1; recruited to the VEGFA promoter via interaction with SARS1 (By similarity). Interacts with BEX4; negatively regulates alpha-tubulin deacetylation by SIRT2 (By similarity).
messages: Midbody
messages: Myelin membrane
messages: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection…
messages: Nucleus
messages: Perikaryon
messages: Phosphorylated at phosphoserine and phosphothreonine. Phosphorylated at Ser-331 by a mitotic kinase CDK1/cyclin B at the G2/M transition; phosphorylation regulates the delay in cell-cycle progression. Phosphorylated at Ser-331 by a mitotic kinase G1/S-specific cyclin E/Cdk2 complex; phosphorylation inactivates SIRT2-mediated alpha-tubulin deacetylation and thereby negatively regulates cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Phosphorylated by cyclin A/Cdk2 and p35-Cdk5 complexes and to a lesser extent by the cyclin D3/Cdk4 and cyclin B/Cdk1, in vitro. Dephosphorylated at Ser-331 by CDC14A and CDC14B around early anaphase (By similarity).
messages: Ubiquitinated.
messages: centriole
messages: centrosome
messages: cytoskeleton
messages: growth cone
messages: perinuclear region
messages: spindle

9601:DCAF11
gene id: 9601:DCAF11
uniprot id: Q5R7H5
names: Function
names: Subunit
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9601:NRP1
gene id: 9601:NRP1
uniprot id: Q5RDN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:XPNPEP3
gene id: 9601:XPNPEP3
uniprot id: A0A2J8TWU7
uniprot id: Q5R9W8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
messages: Cytoplasm
messages: Homodimer. Interacts with TNFRSF1B/TNFR2 (activated) and TRAF2.
messages: Mitochondrion
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CASP8
gene id: 9601:CASP8
uniprot id: A0A2J8WV23
uniprot id: A0A2J8WV26
uniprot id: H2P8A2
uniprot id: Q5RCR7
names: Caution
names: Similarity
messages: Belongs to the peptidase C14A family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PSMB8
gene id: 9601:PSMB8
uniprot id: H2PL25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9601:FAM210B
gene id: 9601:FAM210B
uniprot id: H2P2C5
names: Similarity
messages: Belongs to the FAM210 family.

9601:CCL23
gene id: 9601:CCL23
uniprot id: H2NTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:PSMB2
gene id: 9601:PSMB2
uniprot id: H2N810
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9601:TXNIP
gene id: 9601:TXNIP
uniprot id: Q5R811
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity).
messages: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).
messages: Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

9601:CFDP1
gene id: 9601:CFDP1
uniprot id: H2NRI2
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9601:PIGS
gene id: 9601:PIGS
uniprot id: Q5NVN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:SASS6
gene id: 9601:SASS6
uniprot id: A0A663DGA7
uniprot id: H2N6N4
names: Subcellular Location Annotation
messages: centrosome

9601:LOC100452262
gene id: 9601:LOC100452262
uniprot id: A0A6D2VVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PSMB6
gene id: 9601:PSMB6
uniprot id: A0A2J8SPN6
uniprot id: H2NSC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARV1
gene id: 9601:ARV1
uniprot id: H2N3E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9601:IFNK
gene id: 9601:IFNK
uniprot id: H2PRZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:ANAPC4
gene id: 9601:ANAPC4
uniprot id: Q5RAQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Nucleus
messages: The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. In the context of the APC/C complex, directly interacts with UBE2S.

9601:CD19
gene id: 9601:CD19
uniprot id: A0A663DIG7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SMC3
gene id: 9601:SMC3
uniprot id: A0A2J8W780
uniprot id: Q5R4K5
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication (By similarity). Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin (By similarity).
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Chromosome
messages: Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or meiosis-specific SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with MXI1, MXD3 and MXD4. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with PDS5A and WAPL; regulated by SMC3 acetylation. Interacts (via SMC hinge domain) with KIAA1328 (via N- and C-terminal domains). Interacts with DDX11, SYCP2, RPGR and STAG3. The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (By similarity). Interacts with the NuRD complex component HDAC2; the interaction is direct (By similarity).
messages: Nucleus
messages: Phosphorylated at Ser-1083 in a SPO11-dependent manner.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.
messages: centromere

9601:NAMPT
gene id: 9601:NAMPT
uniprot id: H2PP98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9601:HAL
gene id: 9601:HAL
uniprot id: A0A2J8XMW0
uniprot id: A0A2J8XMX4
uniprot id: H2NIB5
names: Caution
names: Similarity
messages: Belongs to the PAL/histidase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GABRA6
gene id: 9601:GABRA6
uniprot id: H2PHA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:COG7
gene id: 9601:COG7
uniprot id: Q5RES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9601:NCEH1
gene id: 9601:NCEH1
uniprot id: Q5R8Y5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity).
messages: Microsome
messages: N-glycosylated.

9601:FAM221A
gene id: 9601:FAM221A
uniprot id: A0A2J8VE10
uniprot id: A0A2J8VE11
uniprot id: A0A2J8VE43
uniprot id: H2PMM7
names: Caution
names: Similarity
messages: Belongs to the FAM221 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RNF128
gene id: 9601:RNF128
uniprot id: Q5RF74
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination.
messages: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain.
messages: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
messages: Endomembrane system
messages: cytoskeleton
messages: perinuclear region

9601:COL6A3
gene id: 9601:COL6A3
uniprot id: A0A2J8TPU6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TLX2
gene id: 9601:TLX2
uniprot id: H2P5R1
names: Subcellular Location Annotation
messages: Nucleus

9601:RIPPLY1
gene id: 9601:RIPPLY1
uniprot id: A0A2J8VAU6
uniprot id: H2PWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9601:LOC100455882
gene id: 9601:LOC100455882
uniprot id: A0A6D2Y0X9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:PTPN14
gene id: 9601:PTPN14
uniprot id: H2N3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9601:GAA
gene id: 9601:GAA
uniprot id: A0A6D2W041
uniprot id: Q5R7A9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome
messages: Lysosome membrane

9601:MAP3K11
gene id: 9601:MAP3K11
uniprot id: H2NCV2
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9601:LOC100438149
gene id: 9601:LOC100438149
uniprot id: A0A7R8GUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:RRH
gene id: 9601:RRH
uniprot id: H2PE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9601:LOC100435668
gene id: 9601:LOC100435668
uniprot id: A0A663D9V8
uniprot id: H2NS28
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9601:ILDR1
gene id: 9601:ILDR1
uniprot id: A0A2J8W264
uniprot id: Q5R8C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Cell membrane
messages: Homooligomer (By similarity). Interacts with MARVELD2 and OCLN; the interaction is required to recruit MARVELD2 to tricellular contacts. Interacts (via C-terminus) with TRA2A, TRA2B and SRSF1 (By similarity).
messages: Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1.
messages: Membrane
messages: Nucleus
messages: tight junction

9601:KEF63 p13
gene id: 9601:KEF63_p13
uniprot id: P92690
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9601:ZIC2
gene id: 9601:ZIC2
uniprot id: H2NK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9601:HIGD1A
gene id: 9601:HIGD1A
uniprot id: A0A2J8WXN0
uniprot id: Q5NVQ1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respiratory chain supercomplexes (By similarity).
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HES7
gene id: 9601:HES7
uniprot id: A0A2J8RW62
uniprot id: H2NSM4
names: Caution
names: Subunit
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

9601:SEC22B
gene id: 9601:SEC22B
uniprot id: A0A2J8SQF5
uniprot id: Q5RAI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with STX17. Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B as subunit of either complex (By similarity). Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (By similarity).
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9601:RPS13
gene id: 9601:RPS13
uniprot id: A0A6D2Y0V3
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9601:HPCAL4
gene id: 9601:HPCAL4
uniprot id: A0A140TAW6
uniprot id: A0A2J8Y6B6
uniprot id: A0A2J8Y6C6
uniprot id: Q5R6S5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
messages: Probably binds two or three calcium ions.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADORA1
gene id: 9601:ADORA1
uniprot id: Q5RF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity).

9601:TACSTD2
gene id: 9601:TACSTD2
uniprot id: H2N787
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:SLCO4C1
gene id: 9601:SLCO4C1
uniprot id: Q5RFF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP (By similarity). Shows a pH-sensitive substrate specificity estrone 3-sulfate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). May participate in the regulation of membrane transport of ouabain (By similarity). Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells (By similarity). May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity).

9601:C6H6orf120
gene id: 9601:C6H6orf120
uniprot id: A0A663D7A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9601:CDH6
gene id: 9601:CDH6
uniprot id: Q5RCN5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9601:ZNF607
gene id: 9601:ZNF607
uniprot id: A0A6D2W6P9
uniprot id: H2NYM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LAD1
gene id: 9601:LAD1
uniprot id: Q5RE20
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

9601:CD3D
gene id: 9601:CD3D
uniprot id: H2NFG7
names: Subcellular Location Annotation
messages: Membrane

9601:ZNF334
gene id: 9601:ZNF334
uniprot id: Q5RES8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:SOX8
gene id: 9601:SOX8
uniprot id: H2NPN0
names: Subcellular Location Annotation
messages: Nucleus

9601:LYZL1
gene id: 9601:LYZL1
uniprot id: A0A8I5U273
uniprot id: H2NA30
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9601:ZNF251
gene id: 9601:ZNF251
uniprot id: H2PRI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:LOC100438479
gene id: 9601:LOC100438479
uniprot id: A0A2J8X985
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:MAPK1IP1L
gene id: 9601:MAPK1IP1L
uniprot id: A0A2J8WKZ7
uniprot id: Q5R623
names: Caution
names: Similarity
messages: Belongs to the MISS family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GOSR1
gene id: 9601:GOSR1
uniprot id: A0A2J8TN08
uniprot id: A0A2J8TN14
uniprot id: Q5RBL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity).
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:NUDCD3
gene id: 9601:NUDCD3
uniprot id: A0A2J8ST18
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C11H11orf88
gene id: 9601:C11H11orf88
uniprot id: A0A8I5T230
names: Similarity
messages: Belongs to the HOATZ family.

9601:LOC100444465
gene id: 9601:LOC100444465
uniprot id: A0A6D2XLT4
uniprot id: H2PVH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:YPEL5
gene id: 9601:YPEL5
uniprot id: A0A2J8VNF7
uniprot id: Q5RDU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the yippee family.
messages: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity).
messages: Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9 and RANBP10.
messages: Midbody
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome
messages: spindle pole

9601:SLC30A7
gene id: 9601:SLC30A7
uniprot id: Q5RCP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: trans-Golgi network membrane

9601:ITIH1
gene id: 9601:ITIH1
uniprot id: Q5R7R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9601:MICAL2
gene id: 9601:MICAL2
uniprot id: A0A2J8UQ23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNRPA1
gene id: 9601:SNRPA1
uniprot id: A0A6D2XCP7
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9601:SMG9
gene id: 9601:SMG9
uniprot id: A0A6D2XYJ0
uniprot id: K7ET75
names: Similarity
messages: Belongs to the SMG9 family.

9601:DCLK3
gene id: 9601:DCLK3
uniprot id: A0A663D5L6
uniprot id: H2PB72
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AKIRIN2
gene id: 9601:AKIRIN2
uniprot id: H2PJS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9601:ARHGEF2
gene id: 9601:ARHGEF2
uniprot id: A0A2J8VGM5
uniprot id: A0A2J8VGM9
uniprot id: H2N5F5
names: Caution
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Vesicle
messages: spindle
messages: tight junction

9601:COPS6
gene id: 9601:COPS6
uniprot id: A0A2J8RUJ5
uniprot id: Q5REY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B) and COPS9 (By similarity). Interacts with the translation initiation factor EIF3S6 (By similarity). Interacts weakly with RBX1 (By similarity). Directly interacts with COP1 and 14-3-3 protein sigma/SFN (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PAX9
gene id: 9601:PAX9
uniprot id: A0A6D2WV28
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9601:ATL3
gene id: 9601:ATL3
uniprot id: K7EV50
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9601:EFNA3
gene id: 9601:EFNA3
uniprot id: H2N5I3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:PRIM1
gene id: 9601:PRIM1
uniprot id: A0A663DHB7
uniprot id: H2NHR4
names: Caution
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM47
gene id: 9601:TMEM47
uniprot id: A0A663DGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9601:CYP2U1
gene id: 9601:CYP2U1
uniprot id: H2PE27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9601:KIN
gene id: 9601:KIN
uniprot id: H2N9Q5
names: Similarity
messages: Belongs to the KIN17 family.

9601:PCDHA5
gene id: 9601:PCDHA5
uniprot id: Q5R6N6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:NAB1
gene id: 9601:NAB1
uniprot id: Q5R9L1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9601:SOGA3
gene id: 9601:SOGA3
uniprot id: H2PKA5
names: Similarity
messages: Belongs to the SOGA family.

9601:RASGRP3
gene id: 9601:RASGRP3
uniprot id: Q5REI3
names: Similarity
messages: Belongs to the RASGRP family.

9601:CWC25
gene id: 9601:CWC25
uniprot id: H2NUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9601:PFDN6
gene id: 9601:PFDN6
uniprot id: A0A6D2XG24
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9601:RIIAD1
gene id: 9601:RIIAD1
uniprot id: A0A663DF69
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WASL
gene id: 9601:WASL
uniprot id: H2PND3
uniprot id: Q5RFT6
names: Subcellular Location Annotation
messages: Nucleus

9601:MAN2B1
gene id: 9601:MAN2B1
uniprot id: Q5RA64
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9601:MYADM
gene id: 9601:MYADM
uniprot id: Q5R6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9601:APEX2
gene id: 9601:APEX2
uniprot id: H2PVS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9601:P2RX2
gene id: 9601:P2RX2
uniprot id: H2NJ70
uniprot id: H2NJ71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9601:LOC100441723
gene id: 9601:LOC100441723
uniprot id: H2N447
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9601:TRMT6
gene id: 9601:TRMT6
uniprot id: H2P0Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9601:EMG1
gene id: 9601:EMG1
uniprot id: H2NGB4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9601:ZNF214
gene id: 9601:ZNF214
uniprot id: Q5RDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:POFUT1
gene id: 9601:POFUT1
uniprot id: Q5R9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9601:MRPL24
gene id: 9601:MRPL24
uniprot id: A0A6D2XKX2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9601:BEST1
gene id: 9601:BEST1
uniprot id: H2ND68
uniprot id: K7EVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9601:PRLR
gene id: 9601:PRLR
uniprot id: A0A2J8WB29
uniprot id: Q5RAW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9601:LOC100449083
gene id: 9601:LOC100449083
uniprot id: H2NKH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TAL2
gene id: 9601:TAL2
uniprot id: A0A2J8WS79
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TMEM104
gene id: 9601:TMEM104
uniprot id: Q5RCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM104 family.
messages: Membrane

9601:CWC27
gene id: 9601:CWC27
uniprot id: Q5R7W3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
messages: Belongs to the cyclophilin-type PPIase family.
messages: Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.
messages: Nucleus
messages: Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.

9601:DEFB118
gene id: 9601:DEFB118
uniprot id: H2P1J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9601:TPD52
gene id: 9601:TPD52
uniprot id: Q5NVM1
names: Similarity
messages: Belongs to the TPD52 family.

9601:MRPL18
gene id: 9601:MRPL18
uniprot id: A0A663D9M2
uniprot id: H2PKS5
names: Caution
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MASP1
gene id: 9601:MASP1
uniprot id: A0A2J8WHY3
uniprot id: A0A2J8WHZ1
uniprot id: H2PCA7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100447885
gene id: 9601:LOC100447885
uniprot id: A0A2J8WUT0
uniprot id: A0A663DA84
uniprot id: H2P8C5
names: Caution
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GCNT2
gene id: 9601:GCNT2
uniprot id: A0A2J8WMV6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9601:DESI2
gene id: 9601:DESI2
uniprot id: A0A2J8TDN5
uniprot id: Q5R456
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
messages: Interacts with RPS7.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CASP10
gene id: 9601:CASP10
uniprot id: Q5RB11
names: Similarity
messages: Belongs to the peptidase C14A family.

9601:DCAF16
gene id: 9601:DCAF16
uniprot id: A0A6D2XML9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FAM3A
gene id: 9601:FAM3A
uniprot id: A0A2J8RLZ7
uniprot id: Q5R5C3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SAXO2
gene id: 9601:SAXO2
uniprot id: H2NP15
names: Similarity
messages: Belongs to the FAM154 family.

9601:EHD3
gene id: 9601:EHD3
uniprot id: Q5RDJ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9601:PCF11
gene id: 9601:PCF11
uniprot id: A0A2J8V0H4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SNX1
gene id: 9601:SNX1
uniprot id: A0A6D2X869
uniprot id: Q5RFP8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays (By similarity).
messages: Early endosome membrane
messages: Endosome membrane
messages: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).
messages: Membrane
messages: Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, DRD5, DENND5A, KALRN, RHOG (GDP-bound form). The interaction with SNX2 is reported controversially. Interacts with DNAJC13; prevented by presence of HGS. Interacts with HGS (By similarity).
messages: The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipathic helix (AH) in the membrane (By similarity).
messages: lamellipodium
messages: trans-Golgi network membrane

9601:GLT8D2
gene id: 9601:GLT8D2
uniprot id: A0A6D2Y9M2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TJAP1
gene id: 9601:TJAP1
uniprot id: A0A2J8Y4K4
uniprot id: A0A6D2Y8C2
uniprot id: Q5RCZ1
names: Subcellular Location Annotation
messages: Membrane

9601:RAD51B
gene id: 9601:RAD51B
uniprot id: A0A2J8WM79
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPP5C
gene id: 9601:PPP5C
uniprot id: Q5R8T2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9601:SLC10A1
gene id: 9601:SLC10A1
uniprot id: H2NLN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9601:ESRP2
gene id: 9601:ESRP2
uniprot id: A0A663D9Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MCL1
gene id: 9601:MCL1
uniprot id: A0A2J8VEQ7
uniprot id: H2N5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9601:SPARCL1
gene id: 9601:SPARCL1
uniprot id: Q5R5W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9601:SARAF
gene id: 9601:SARAF
uniprot id: H2PPZ0
uniprot id: Q5R491
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity).
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
messages: The cytoplasmic C-terminal region mediates interaction with STIM1, while the N-terminal lumenal region mediates regulation of SOCE activity.

9601:CPT2
gene id: 9601:CPT2
uniprot id: A0A2J8V8W1
uniprot id: H2N7C9
names: Caution
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SLC16A1
gene id: 9601:SLC16A1
uniprot id: Q5R9R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9601:MOS
gene id: 9601:MOS
uniprot id: H2PQC2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:BICD2
gene id: 9601:BICD2
uniprot id: A0A2J8WP70
uniprot id: H2PSP8
names: Caution
names: Similarity
messages: Belongs to the BicD family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ETNPPL
gene id: 9601:ETNPPL
uniprot id: A0A2J8XQC3
uniprot id: H2PE32
names: Caution
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TYRO3
gene id: 9601:TYRO3
uniprot id: Q5RFB5
names: Subcellular Location Annotation
messages: Membrane

9601:SENP7
gene id: 9601:SENP7
uniprot id: A0A2J8T909
names: Caution
names: Similarity
messages: Belongs to the peptidase C48 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLA2G16
gene id: 9601:PLA2G16
uniprot id: Q5R611
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H-rev107 family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity).
messages: Interacts with PPP2R1A; this interaction might decrease PP2A activity.
messages: Lysosome membrane
messages: Mitochondrion membrane
messages: Nucleus envelope
messages: Peroxisome membrane
messages: The C-terminal transmembrane domain is required for the targeting of the protein to damaged organelles.
messages: cytosol
messages: perinuclear region

9601:MUM1L1
gene id: 9601:MUM1L1
uniprot id: H2PWE2
names: Similarity
messages: Belongs to the PWWP3A family.

9601:HSF1
gene id: 9601:HSF1
uniprot id: A0A2J8RHN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LAMP5
gene id: 9601:LAMP5
uniprot id: Q5R5V2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Endosome membrane
messages: Glycosylated.
messages: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
messages: Recycling endosome
messages: dendrite
messages: growth cone membrane
messages: synaptic vesicle membrane

9601:ZNF688
gene id: 9601:ZNF688
uniprot id: A0A2J8TKN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:AP1G2
gene id: 9601:AP1G2
uniprot id: A0A2J8TRM8
uniprot id: A0A6D2WXM4
names: Caution
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:OTP
gene id: 9601:OTP
uniprot id: H2PFX9
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100447246
gene id: 9601:LOC100447246
uniprot id: A0A2J8UE04
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CX3CL1
gene id: 9601:CX3CL1
uniprot id: A0A6D2XPT7
uniprot id: H2NR02
uniprot id: Q5RBF7
names: Caution
names: Subcellular Location Annotation
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ART1
gene id: 9601:ART1
uniprot id: H2NEI6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9601:NT5DC2
gene id: 9601:NT5DC2
uniprot id: H2PAJ3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9601:IFI16
gene id: 9601:IFI16
uniprot id: Q5RD14
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIN-200 family.
messages: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors (By similarity).
messages: Cytoplasm
messages: Forms homooligomers. Interacts with TMEM173, AIM2, PYCARD and CASP1. Interacts with BRCA1, TP53, E2F1, RB1 and SP1. Interacts with MTA1 (By similarity). Interacts with MTA1. Interacts with PYDC5 (By similarity).
messages: Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location.
messages: Nucleus
messages: Phosphorylated on Ser and Thr.
messages: The HIN-20 domains mediates dsDNA binding via electrostatic interactions.

9601:TSC22D2
gene id: 9601:TSC22D2
uniprot id: A0A8I5U5E1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9601:SLC35D1
gene id: 9601:SLC35D1
uniprot id: A0A2J8WPS9
uniprot id: Q5RDC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BNIP3L
gene id: 9601:BNIP3L
uniprot id: A0A6D2WEF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9601:TMCC2
gene id: 9601:TMCC2
uniprot id: Q5RAL5
names: Similarity
messages: Belongs to the TEX28 family.

9601:IL17F
gene id: 9601:IL17F
uniprot id: H2PJC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9601:MT2A
gene id: 9601:MT2A
uniprot id: A0A2J8VYS4
uniprot id: Q5NVS0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: This metallothionein binds zinc.

9601:UBE2N
gene id: 9601:UBE2N
uniprot id: A0A2J8XNH2
uniprot id: Q5R7J6
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitination (By similarity). Activity is inhibited by GPS2, leading to prevent 'Lys-63'-linked polyubiquitination (By similarity).
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.
messages: Heterodimer with UBE2V2 (By similarity). Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (By similarity). Interacts with RNF8 and RNF168 (By similarity). Interacts with RNF11 (By similarity). Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair (By similarity). Interacts with ARIH2 (via RING-type 2) (By similarity). Interacts with OTUB1; leading to inhibit E2-conjugating activity (By similarity). Interacts with GPS2; leading to inhibit E2-conjugating activity (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).
messages: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CKS1B
gene id: 9601:CKS1B
uniprot id: H2N5J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9601:NKG7
gene id: 9601:NKG7
uniprot id: H2NZW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9601:ORAI1
gene id: 9601:ORAI1
uniprot id: A0A2J8XJQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CXCL11
gene id: 9601:CXCL11
uniprot id: A0A6D2VUL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:SRRM1
gene id: 9601:SRRM1
uniprot id: Q5R5Q2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Citrullinated by PADI4.
messages: Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with DDX39B, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.
messages: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
messages: Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of nuclear speckles.

9601:HTRA1
gene id: 9601:HTRA1
uniprot id: H2NBU2
names: Similarity
messages: Belongs to the peptidase S1C family.

9601:EYA3
gene id: 9601:EYA3
uniprot id: A0A2J8Y5S9
uniprot id: H2N8B5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ESR1
gene id: 9601:ESR1
uniprot id: A0A6D2XRP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9601:CCNG1
gene id: 9601:CCNG1
uniprot id: A0A2J8X737
uniprot id: A0A6D2WNX3
uniprot id: Q5R765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9601:GALM
gene id: 9601:GALM
uniprot id: Q5R8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Cytoplasm
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.

9601:RRAGA
gene id: 9601:RRAGA
uniprot id: H2PS37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9601:LOC100431733
gene id: 9601:LOC100431733
uniprot id: H2PDA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9601:CD2
gene id: 9601:CD2
uniprot id: H2N682
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:PTGDR2
gene id: 9601:PTGDR2
uniprot id: H2ND97
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:MFN2
gene id: 9601:MFN2
uniprot id: Q5RAE9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9601:UBE2L6
gene id: 9601:UBE2L6
uniprot id: A0A2J8WEG4
uniprot id: H2NDG0
names: Caution
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SZRD1
gene id: 9601:SZRD1
uniprot id: A0A2J8S959
uniprot id: A0A2J8S964
uniprot id: A0A2J8S965
uniprot id: H2N8X2
uniprot id: Q5RE12
names: Caution
names: Similarity
messages: Belongs to the SZRD1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PAQR5
gene id: 9601:PAQR5
uniprot id: Q5R9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9601:ACTL8
gene id: 9601:ACTL8
uniprot id: A0A6D2WQ50
names: Similarity
messages: Belongs to the actin family.

9601:LCMT1
gene id: 9601:LCMT1
uniprot id: H2NQG1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9601:LOC100445423
gene id: 9601:LOC100445423
uniprot id: H2PDG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9601:CDK5RAP2
gene id: 9601:CDK5RAP2
uniprot id: H2PT81
names: Subcellular Location Annotation
messages: centrosome

9601:UMPS
gene id: 9601:UMPS
uniprot id: Q5R514
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
messages: Homodimer; dimerization is required for enzymatic activity.
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9601:SFXN3
gene id: 9601:SFXN3
uniprot id: A0A663D8C2
uniprot id: H2NBC6
uniprot id: Q5RD16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.
messages: Mitochondrion membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PITX1
gene id: 9601:PITX1
uniprot id: A0A6D2W1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9601:CPLX3
gene id: 9601:CPLX3
uniprot id: K7EUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9601:KCNA5
gene id: 9601:KCNA5
uniprot id: H2NG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9601:PNOC
gene id: 9601:PNOC
uniprot id: A0A2J8X5A2
uniprot id: H2PPX8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTFMT
gene id: 9601:MTFMT
uniprot id: A0A6D2XHT0
names: Similarity
messages: Belongs to the Fmt family.

9601:TMOD1
gene id: 9601:TMOD1
uniprot id: A0A6D2Y8A2
names: Subcellular Location Annotation
messages: cytoskeleton

9601:ZFP69
gene id: 9601:ZFP69
uniprot id: A0A6D2XNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:MAPKAPK3
gene id: 9601:MAPKAPK3
uniprot id: A0A6D2W999
names: Similarity
messages: Belongs to the protein kinase superfamily.

9601:DDX42
gene id: 9601:DDX42
uniprot id: Q5R7D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
messages: Belongs to the DEAD box helicase family. DDX42 subfamily.
messages: Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53.
messages: Cytoplasm
messages: Nucleus

9601:NEUROD6
gene id: 9601:NEUROD6
uniprot id: H2PMG4
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9601:TTR
gene id: 9601:TTR
uniprot id: Q5NVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).

9601:MMP13
gene id: 9601:MMP13
uniprot id: H2NF36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9601:NFAM1
gene id: 9601:NFAM1
uniprot id: A0A2J8TWJ6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CSTF3
gene id: 9601:CSTF3
uniprot id: Q5RDW9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1 (By similarity).
messages: Nucleus
messages: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

9601:ARPP19
gene id: 9601:ARPP19
uniprot id: A0A2J8VBU8
uniprot id: A0A2J8VBV3
uniprot id: A0A2J8VBV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100440002
gene id: 9601:LOC100440002
uniprot id: H2NEE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:GLI1
gene id: 9601:GLI1
uniprot id: A0A2J8UHB6
uniprot id: H2NHT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DPP3
gene id: 9601:DPP3
uniprot id: Q5RCB1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9601:CRYL1
gene id: 9601:CRYL1
uniprot id: A0A2J8RJH4
uniprot id: A0A8I5YNK5
uniprot id: Q5RDZ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Cytoplasm
messages: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
messages: Homodimer.
messages: Inhibited by malonate.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BARX2
gene id: 9601:BARX2
uniprot id: H2NFV4
names: Subcellular Location Annotation
messages: Nucleus

9601:PITRM1
gene id: 9601:PITRM1
uniprot id: Q5RDG3
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber.
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mainly exists in a closed and catalytically competent conformation but a closed-to-open switch allows substrate entry into the catalytic chamber. Substrate binding induces closure and dimerization. A disulfide bond may lock the enzyme in a closed conformation preventing substrate entry into the catalytic chamber, participating in redox regulation of the enzyme. Inhibited by metal-chelating agents. Inhibited by nickel and zinc excess, and slightly activated by manganese.
messages: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

9601:GPR50
gene id: 9601:GPR50
uniprot id: H2PX28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:ZNF665
gene id: 9601:ZNF665
uniprot id: Q5R8X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:LDHB
gene id: 9601:LDHB
uniprot id: A0A6D2XUS2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9601:ADIPOR2
gene id: 9601:ADIPOR2
uniprot id: H2NG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9601:RPL24
gene id: 9601:RPL24
uniprot id: H2P9V3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9601:PRMT7
gene id: 9601:PRMT7
uniprot id: A0A8I5TZS8
uniprot id: H2NRB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9601:CLU
gene id: 9601:CLU
uniprot id: A0A2J8X5F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9601:GFOD2
gene id: 9601:GFOD2
uniprot id: A0A6D2WZK8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9601:DNAJC19
gene id: 9601:DNAJC19
uniprot id: A0A2J8WGW3
uniprot id: Q5RF34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Interacts with PHB2; the interaction associates DNAJC19 with the prohibitin complex. Interacts with TIMM16/PAM16 (By similarity). May be a component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity).
messages: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100939434
gene id: 9601:LOC100939434
uniprot id: A0A8I5TXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:KANSL2
gene id: 9601:KANSL2
uniprot id: Q5R802
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9601:ETV3L
gene id: 9601:ETV3L
uniprot id: H2N5A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:SEPT2
gene id: 9601:SEPT2
uniprot id: A0A2J8RPL7
uniprot id: A0A2J8RPL9
uniprot id: Q5RA66
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Coordinated expression with SEPTIN6 and SEPTIN7.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity).
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit (By similarity). Interaction between SEPTIN2 and SEPTIN7 seems indirect. Interacts with SEPTIN5 (By similarity). Interaction with SEPTIN4 not detected (By similarity). Interacts with SEPTIN9. Component of a septin core octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus. Interacts with MAP4. Interacts with DZIP1L (By similarity).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cell cortex
messages: cilium membrane
messages: cytoskeleton
messages: flagellum
messages: spindle

9601:CUL3
gene id: 9601:CUL3
uniprot id: A0A2J8TUW9
uniprot id: H2P8S3
names: Similarity
messages: Belongs to the cullin family.

9601:ETV2
gene id: 9601:ETV2
uniprot id: A0A2J8RRR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:FZD1
gene id: 9601:FZD1
uniprot id: H2PMY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:RUNDC3A
gene id: 9601:RUNDC3A
uniprot id: A0A2J8UYF6
uniprot id: Q5R565
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with the GTP-bound form of RAP2A.
messages: May act as an effector of RAP2A in neuronal cells.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PTCD3
gene id: 9601:PTCD3
uniprot id: Q5R8W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).
messages: Mitochondrial RNA-binding protein that has a role in mitochondrial translation.
messages: Mitochondrion

9601:PUS3
gene id: 9601:PUS3
uniprot id: A0A6D2XY89
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9601:XKR6
gene id: 9601:XKR6
uniprot id: A0A6D2XQX2
uniprot id: H2PPK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GCM2
gene id: 9601:GCM2
uniprot id: H2PHX4
names: Subcellular Location Annotation
messages: Nucleus

9601:P2RY2
gene id: 9601:P2RY2
uniprot id: A0A6D2XT83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:STYX
gene id: 9601:STYX
uniprot id: Q5RDP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (By similarity).
messages: Contains a Gly residue instead of a conserved Cys residue at position 120 in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (By similarity). The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may protect them from phosphatases (By similarity).
messages: Interacts with MAPK1; independently of MAPK1 phosphorylation status (By similarity). Interacts with CARHSP1/Crhsp-24 (By similarity). Interacts (via FQQ motif) with FBXW7 (via F-box domain); the interaction is direct and prevents FBXW7 interaction with SKP1, a component of the SCF(FBXW7) complex.
messages: Nucleus
messages: cytosol

9601:CD46
gene id: 9601:CD46
uniprot id: A0A2J8V6K7
uniprot id: A0A2J8V6K9
uniprot id: A0A2J8V6L4
uniprot id: A0A2J8V6L7
uniprot id: A0A2J8V6M7
uniprot id: A0A2J8V6N7
uniprot id: H2N3V0
uniprot id: Q5R4D0
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sushi domains 3 and 4 are the most important for interaction with C3b and C4b.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: acrosome inner membrane

9601:TP53INP1
gene id: 9601:TP53INP1
uniprot id: A0A2J8UGI8
uniprot id: A0A6D2W8V2
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9601:RBMS3
gene id: 9601:RBMS3
uniprot id: A0A2J8WYU3
uniprot id: Q5RBD3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds poly(A) and poly(U) oligoribonucleotides.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MISP
gene id: 9601:MISP
uniprot id: Q5RBH3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1 (By similarity).
messages: Belongs to the MISP family.
messages: Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase (By similarity).
messages: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity).
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9601:LOC100453373
gene id: 9601:LOC100453373
uniprot id: H2N354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CTNNA1
gene id: 9601:CTNNA1
uniprot id: H2PGP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

9601:PAF1
gene id: 9601:PAF1
uniprot id: Q5RAX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAF1 family.
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity).
messages: Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with POLR2A, TCEA1, SKIC3, KMT2A/MLL1, SUPT5H, RNF20 and RNF40. Interacts with UBE2E1 (By similarity).
messages: Nucleus

9601:ACKR4
gene id: 9601:ACKR4
uniprot id: H2PBG1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:CABP4
gene id: 9601:CABP4
uniprot id: A0A2J8U0D9
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:USP15
gene id: 9601:USP15
uniprot id: A0A2J8UGL0
uniprot id: H2NHW3
uniprot id: K7ETJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9601:BSG
gene id: 9601:BSG
uniprot id: Q5R758
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

9601:MKRN2
gene id: 9601:MKRN2
uniprot id: H2P9A3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:ADD2
gene id: 9601:ADD2
uniprot id: A0A2J8XBP7
uniprot id: Q5R5V7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
messages: Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1 (By similarity).
messages: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:DPYS
gene id: 9601:DPYS
uniprot id: H2PR01
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9601:CAMKMT
gene id: 9601:CAMKMT
uniprot id: H2P6C9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9601:MGRN1
gene id: 9601:MGRN1
uniprot id: H2NQ13
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9601:RAB9B
gene id: 9601:RAB9B
uniprot id: A0A2J8VAY8
uniprot id: Q5R4W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1. The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone.
messages: Involved in the transport of proteins between the endosomes and the trans Golgi network.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: phagosome membrane

9601:GFRAL
gene id: 9601:GFRAL
uniprot id: H2PJF3
names: Similarity
messages: Belongs to the GDNFR family.

9601:SLC16A11
gene id: 9601:SLC16A11
uniprot id: H2NSH0
names: Subcellular Location Annotation
messages: Membrane

9601:KCNK16
gene id: 9601:KCNK16
uniprot id: H2PIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9601:HOMER1
gene id: 9601:HOMER1
uniprot id: Q5RD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9601:WEE2
gene id: 9601:WEE2
uniprot id: H2PNQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9601:SLC4A11
gene id: 9601:SLC4A11
uniprot id: H2P1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9601:CALR
gene id: 9601:CALR
uniprot id: H2NXQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

9601:SLC6A20
gene id: 9601:SLC6A20
uniprot id: A0A2J8TFH1
uniprot id: H2PAY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9601:PPP3CC
gene id: 9601:PPP3CC
uniprot id: H2PPS1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9601:ERAP2
gene id: 9601:ERAP2
uniprot id: Q5RFP3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ERAP1.
messages: N-glycosylated.

9601:PPP2R2A
gene id: 9601:PPP2R2A
uniprot id: H2PPV9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9601:G6PC3
gene id: 9601:G6PC3
uniprot id: H2NTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9601:TGFBR2
gene id: 9601:TGFBR2
uniprot id: A0A2J8WYY1
uniprot id: H2PBA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9601:SPOCK2
gene id: 9601:SPOCK2
uniprot id: A0A2J8U5W6
uniprot id: A0A2J8U5Y5
uniprot id: A0A6D2X950
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATG4A
gene id: 9601:ATG4A
uniprot id: Q5R699
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy.
messages: Cytoplasm
messages: Inhibited by N-ethylmaleimide. Redox-regulated during autophagy since reducing conditions activate ATG4A whereas an oxidizing environment such as the presence of H(2)O(2) inhibits its activity.
messages: Interacts with ATG9A; the interaction is direct.
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins.

9601:GABRB3
gene id: 9601:GABRB3
uniprot id: A0A8I3B2C2
uniprot id: K7EVN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:TMEM182
gene id: 9601:TMEM182
uniprot id: A0A2J8RU09
uniprot id: A0A663D8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9601:LYN
gene id: 9601:LYN
uniprot id: A0A2J8UNA4
uniprot id: H2PQC0
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYNN
gene id: 9601:MYNN
uniprot id: Q5R5N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:PPP2R5D
gene id: 9601:PPP2R5D
uniprot id: H2PJ35
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9601:CDNF
gene id: 9601:CDNF
uniprot id: A0A2J8VKL2
uniprot id: H2N9T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9601:POLR2C
gene id: 9601:POLR2C
uniprot id: A0A6D2WS96
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9601:CCNK
gene id: 9601:CCNK
uniprot id: A0A6D2XS62
uniprot id: K7ETF7
names: Similarity
messages: Belongs to the cyclin family.

9601:MCM7
gene id: 9601:MCM7
uniprot id: H2PLL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9601:ARMC6
gene id: 9601:ARMC6
uniprot id: Q5RD03
names: Caution
names: PTM
names: Similarity
messages: Belongs to the ARMC6 family.
messages: It is uncertain whether Met-1 or Met-26 is the initiator.
messages: Methylated at His-263 by METTL9.

9601:CXCL3
gene id: 9601:CXCL3
uniprot id: H2PDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9601:BRS3
gene id: 9601:BRS3
uniprot id: H2PWX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9601:SRMS
gene id: 9601:SRMS
uniprot id: H2P2M2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9601:GJC2
gene id: 9601:GJC2
uniprot id: H2N3H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9601:CERS4
gene id: 9601:CERS4
uniprot id: A0A2J8RD37
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9601:DDX49
gene id: 9601:DDX49
uniprot id: A0A2J8T5N6
uniprot id: H2NY48
names: Caution
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:FABP3
gene id: 9601:FABP3
uniprot id: A0A663DIG0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9601:ZBTB8A
gene id: 9601:ZBTB8A
uniprot id: A0A2J8Y781
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100449561
gene id: 9601:LOC100449561
uniprot id: A0A6D2WGT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9601:TMCO6
gene id: 9601:TMCO6
uniprot id: A0A2J8VPB5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100460871
gene id: 9601:LOC100460871
uniprot id: A0A2J8WN73
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNH8
gene id: 9601:KCNH8
uniprot id: H2PBC8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9601:CLDN16
gene id: 9601:CLDN16
uniprot id: H2PCC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9601:HOXC13
gene id: 9601:HOXC13
uniprot id: H2NHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9601:CCDC88A
gene id: 9601:CCDC88A
uniprot id: A0A2J8XCP8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KCNK7
gene id: 9601:KCNK7
uniprot id: A0A6D2XD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9601:CTGF
gene id: 9601:CTGF
uniprot id: H2PKC3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:CALHM1
gene id: 9601:CALHM1
uniprot id: H2NBH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9601:NDUFB3
gene id: 9601:NDUFB3
uniprot id: A0A6D2W0C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9601:NDST2
gene id: 9601:NDST2
uniprot id: H2NAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9601:ANP32E
gene id: 9601:ANP32E
uniprot id: Q5RAC3
names: Similarity
messages: Belongs to the ANP32 family.

9601:GSTZ1
gene id: 9601:GSTZ1
uniprot id: A0A2J8W5V5
uniprot id: H2NLW5
names: Caution
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TARS
gene id: 9601:TARS
uniprot id: Q5RA09
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9601:CNTROB
gene id: 9601:CNTROB
uniprot id: A0A6D2Y183
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AAR2
gene id: 9601:AAR2
uniprot id: Q5R5N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.
messages: Interacts with PRPF8 (via RNase H homology domain) (By similarity). Component of a U5 snRNP complex that contains PRPF8 (By similarity).

9601:LOC100440309
gene id: 9601:LOC100440309
uniprot id: H2P3T9
names: Subcellular Location Annotation
messages: Nucleus

9601:USP39
gene id: 9601:USP39
uniprot id: A0A6D2X8Z9
uniprot id: Q5R761
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Lacks the conserved His and Cys residues that are essential for the activity of de-ubiquitinating enzymes. Lacks ubiquitin C-terminal hydrolase activity.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.
messages: The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.

9601:LBR
gene id: 9601:LBR
uniprot id: Q5R7H4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG4/ERG24 family.
messages: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with CBX5 (By similarity). Interacts with DNA (By similarity). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (By similarity). Interacts with lamin B (By similarity). Interacts with CLNK (By similarity).
messages: Nucleus
messages: Nucleus inner membrane
messages: Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin (By similarity). It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (By similarity). Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated by SRPK1 (By similarity). In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin (By similarity).
messages: The Tudor domain may not recognize methylation marks, but rather bind unassembled free histone H3.

9601:LOC100436243
gene id: 9601:LOC100436243
uniprot id: A0A2J8W3V7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DIO1
gene id: 9601:DIO1
uniprot id: A0A2J8V8X7
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9601:FGFBP1
gene id: 9601:FGFBP1
uniprot id: H2PF09
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9601:POLR2H
gene id: 9601:POLR2H
uniprot id: H2PC71
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9601:CCL28
gene id: 9601:CCL28
uniprot id: A0A6D2X156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:PCCB
gene id: 9601:PCCB
uniprot id: A0A6D2WXS5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UBE2T
gene id: 9601:UBE2T
uniprot id: H2N457
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9601:POP4
gene id: 9601:POP4
uniprot id: A0A2J8SAG6
uniprot id: Q5R7B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:CLIC4
gene id: 9601:CLIC4
uniprot id: Q5R957
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel CLIC family.
messages: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Monomer. Interacts with HRH3 (By similarity).
messages: Nucleus

9601:KLHL18
gene id: 9601:KLHL18
uniprot id: A0A2J8TFN6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CDC6
gene id: 9601:CDC6
uniprot id: A0A6D2VUQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9601:S100PBP
gene id: 9601:S100PBP
uniprot id: A0A6D2X6W7
names: Subcellular Location Annotation
messages: Nucleus

9601:GATD1
gene id: 9601:GATD1
uniprot id: A0A2J8XSK0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLOCK
gene id: 9601:CLOCK
uniprot id: Q5RAK8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Forms a heterodimer with BMAL1 (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and for phosphorylation of both CLOCK and BMAL1 (By similarity). Interacts with NR3C1 in a ligand-dependent fashion (By similarity). Interacts with ESR1 and estrogen stimulates this interaction (By similarity). Interacts with the complex p35/CDK5 (By similarity). Interacts with RELA/p65 (By similarity). Interacts with KAT2B, CREBBP and EP300 (By similarity). Interacts with ID1 and ID3 (By similarity). Interacts with ID2 (By similarity). Interacts with MTA1 (By similarity). Interacts with OGA (By similarity). Interacts with SIRT1 (By similarity). Interacts with CIPC (By similarity). Interacts with EZH2 (By similarity). Interacts with EIF4E, PIWIL1 and DDX4 (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with MYBBP1A (By similarity). Interacts with THRAP3 (By similarity). Interacts with MED1; this interaction requires the presence of THRAP3 (By similarity). Interacts with NCOA2 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1. Interacts with ASS1 and IMPDH2; in a circadian manner. Interacts with NDUFA9 (By similarity). Interacts with PIWIL2 (via PIWI domain) (By similarity). Interacts with HNF4A (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2.
messages: Phosphorylation is dependent on the CLOCK-BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver. May be phosphorylated by CSNK1D and CKSN1E (By similarity).
messages: Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.
messages: cytosol

9601:EXOSC7
gene id: 9601:EXOSC7
uniprot id: H2PAZ3
names: Subcellular Location Annotation
messages: Cytoplasm

9601:TFB1M
gene id: 9601:TFB1M
uniprot id: Q5R4V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity).
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).

9601:ZFP1
gene id: 9601:ZFP1
uniprot id: A0A6D2YCI5
uniprot id: Q5RC79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9601:CTSA
gene id: 9601:CTSA
uniprot id: A0A2J8XVF7
uniprot id: Q5R786
names: Caution
names: Similarity
messages: Belongs to the peptidase S10 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MTRNR2L3
gene id: 9601:MTRNR2L3
uniprot id: A0A8I5YLA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9601:C5H5orf46
gene id: 9601:C5H5orf46
uniprot id: A0A663DHD2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ATP13A5
gene id: 9601:ATP13A5
uniprot id: H2PCD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9601:TACR2
gene id: 9601:TACR2
uniprot id: H2NAP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:CAMK2A
gene id: 9601:CAMK2A
uniprot id: A0A2J8X624
uniprot id: Q5RCC4
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
messages: Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
messages: Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
messages: Postsynaptic density
messages: Synapse
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: There are 4 genes encoding calcium/calmodulin-dependent protein kinase type II chains: CAMK2A, CAMK2B, CAMK2G and CAMK2D. The corresponding proteins assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (By similarity). Interacts with BAALC. Interacts with MPDZ. Interacts with SYN1. Interacts with CAMK2N2. Interacts with SYNGAP1. Interacts with SYNPO2 (By similarity). Interacts with SHANK3. Interacts with GRIN2B. Interacts with CACNB2. Interacts with LRRC7. Interacts with GRM5 (By similarity). Interacts with DAGLA (via C-terminal); this interaction is enhanced by autophosphorylation of CAMK2A at Thr-286 (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2A activation by Ca(2+) (By similarity).
messages: dendrite
messages: dendritic spine

9601:TMED6
gene id: 9601:TMED6
uniprot id: H2NRC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9601:LOC100446754
gene id: 9601:LOC100446754
uniprot id: H2N343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:TMEM129
gene id: 9601:TMEM129
uniprot id: A0A6D2YB80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9601:APITD1
gene id: 9601:APITD1
uniprot id: A0A6D2XY30
uniprot id: H2N958
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Belongs to the somatostatin family.
messages: Nucleus
messages: Secreted
messages: kinetochore

9601:APOC2
gene id: 9601:APOC2
uniprot id: A0A6D2VSA1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9601:BCCIP
gene id: 9601:BCCIP
uniprot id: A0A2J8W670
uniprot id: A0A2J8W679
uniprot id: A0A2J8W692
uniprot id: Q5R4S4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: spindle pole

9601:RARRES2
gene id: 9601:RARRES2
uniprot id: A0A2J8RK16
uniprot id: Q5R551
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin (By similarity).
messages: Secreted
messages: Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity. For example, the removal of six amino acids results in chemerin-157, which exhibits the highest activity, while removal of seven amino acids results in chemerin-156 which has slightly less activity. Some proteases are able to cleave at more than one site and chemerin forms may be sequentially processed by different enzymes to modulate activity levels. The coordinated expression and activity of chemerin-modifying enzymes is essential for regulating its bioactivation, inactivation and, consequently, biological function. Cathepsin G cleaves seven C-terminal amino acids from prochemerin (chemerin-156), elastase is able to cleave six (chemerin-157), eight (chemerin-155) or eleven (chemerin-152), plasmin cleaves five amino acids (chemerin-158), and tryptase cleaves five (chemerin-158) or eight (chemerin-155). Multiple cleavages might be required to fully activate chemerin, with an initial tryptase cleavage resulting in chemerin with low activity (chemerin-158), and a second cleavage by carboxypeptidase N or B producing highly active chemerin (chemerin-157).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:HNF1B
gene id: 9601:HNF1B
uniprot id: A0A2J8RCE9
uniprot id: Q5RER5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HNF1 homeobox family.
messages: Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha (By similarity). Interacts (via HNF-p1 domain) with PCBD1; the interaction increases its transactivation activity (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity).

9601:PABPC4
gene id: 9601:PABPC4
uniprot id: A0A2J8Y6D1
uniprot id: A0A2J8Y6D2
uniprot id: A0A2J8Y6D6
uniprot id: H2N7W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IMP3
gene id: 9601:IMP3
uniprot id: A0A6D2VUE9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9601:SLC35A2
gene id: 9601:SLC35A2
uniprot id: A0A2J8R8J1
uniprot id: A0A2J8R8J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9601:TGM5
gene id: 9601:TGM5
uniprot id: A0A2J8S5E2
uniprot id: H2NN08
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:PIK3C2A
gene id: 9601:PIK3C2A
uniprot id: Q5RAY1
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Ca(2+) or Mg(2+). Mn(2+) cannot be used.
messages: Cell membrane
messages: Cytoplasm
messages: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function (By similarity). Involved in the regulation of ciliogenesis and trafficking of ciliary components (By similarity).
messages: Nucleus
messages: Only slightly inhibited by wortmannin and LY294002. Activated by clathrin and insulin (By similarity).
messages: Part of a complex with ERBB2 and EGFR (By similarity). Interacts with clathrin trimers (By similarity). Interacts with SBF2/MTMR13 (By similarity).
messages: Phosphorylated on Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation. Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity).
messages: clathrin-coated vesicle
messages: trans-Golgi network

9601:ALG2
gene id: 9601:ALG2
uniprot id: H2PSW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9601:ALDH1B1
gene id: 9601:ALDH1B1
uniprot id: Q5R6B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity).
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9601:AMMECR1L
gene id: 9601:AMMECR1L
uniprot id: A0A2J8VLU1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DDI2
gene id: 9601:DDI2
uniprot id: H2N8Z2
names: Similarity
messages: Belongs to the DDI1 family.

9601:LOC100439777
gene id: 9601:LOC100439777
uniprot id: A0A6D2WR21
names: Similarity
messages: Belongs to the cytochrome P450 family.

9601:TPH1
gene id: 9601:TPH1
uniprot id: H2NDZ5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9601:ITGB1BP1
gene id: 9601:ITGB1BP1
uniprot id: A0A2J8V3X5
uniprot id: Q5R5S7
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts (via N-terminus and PTB domain) with ROCK1. Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminal region) with ITGB1 (via C-terminal cytoplasmic tail); the interaction prevents talin TLN1 binding to ITGB1 and KRIT1 and ITGB1 compete for the same binding site. Interacts with KRIT1 (via N-terminal NPXY motif); the interaction induces the opening conformation of KRIT1 and KRIT1 and ITGB1 compete for the same binding site. Isoform 2 does not interact with ITGB1. Interacts with CDC42 (GTP- or GDP-bound form); the interaction is increased with the CDC42-membrane bound forms and prevents both CDC42 activation and cell spreading. Interacts (via C-terminal domain region) with NME2. Interacts with FERMT2 and RAC1 (By similarity).
messages: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity).
messages: Nucleus
messages: Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton
messages: lamellipodium
messages: ruffle

9601:RFC4
gene id: 9601:RFC4
uniprot id: A0A6D2W461
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9601:ADAMTS16
gene id: 9601:ADAMTS16
uniprot id: H2PF51
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9601:FRMD3
gene id: 9601:FRMD3
uniprot id: Q5R803
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

9601:ARL5A
gene id: 9601:ARL5A
uniprot id: H2P7J7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9601:RAB5C
gene id: 9601:RAB5C
uniprot id: Q5R7L7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Early endosome membrane
messages: Interacts with EEA1 and INCA1 (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-85 disrupts this interaction (By similarity).
messages: Melanosome
messages: Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9601:DNAJB9
gene id: 9601:DNAJB9
uniprot id: Q5R9A4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).
messages: Endoplasmic reticulum lumen
messages: Interacts with HSPA5/BiP; interaction is direct (By similarity). Interacts with ERN1/IRE1 (via the luminal region) (By similarity). Interacts with DERL1 (By similarity).
messages: The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences.

9601:POU5F1
gene id: 9601:POU5F1
uniprot id: A0A6D2YBI4
uniprot id: H2PL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9601:LOC100454770
gene id: 9601:LOC100454770
uniprot id: H2PA86
names: Similarity
messages: Belongs to the pro/parathymosin family.

9601:LHX8
gene id: 9601:LHX8
uniprot id: A0A2J8WQ37
uniprot id: H2N712
names: Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GRP
gene id: 9601:GRP
uniprot id: A0A2J8W3A1
uniprot id: A0A6D2XUZ3
uniprot id: H2NWF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: neuron projection
messages: secretory vesicle lumen

9601:PTX3
gene id: 9601:PTX3
uniprot id: H2PBU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:SLC22A2
gene id: 9601:SLC22A2
uniprot id: Q5R5H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Mediates tubular uptake of organic compounds from circulation. Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity). Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity).
messages: Membrane

9601:SPTLC1
gene id: 9601:SPTLC1
uniprot id: Q5R9T5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with SPTLC2 or SPTLC3. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB. The composition of the complex will define the substrate specificity. Interacts with SPTSSA and SPTSSB; the interaction is direct. Interacts with ORMDL3 (By similarity). Interacts with RTN4 (isoform B) (By similarity).
messages: Phosphorylation at Tyr-164 inhibits activity and promotes cell survival.
messages: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity).

9601:POLR3F
gene id: 9601:POLR3F
uniprot id: H2P144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9601:BCAP29
gene id: 9601:BCAP29
uniprot id: A0A2J8TAC4
uniprot id: Q5R9U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer and heterodimer with BCAP31. Binds CASP8 as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity).
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DNAJC16
gene id: 9601:DNAJC16
uniprot id: A0A2J8S8Z9
uniprot id: H2N8Z4
uniprot id: Q5RCM7
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PWP2
gene id: 9601:PWP2
uniprot id: Q5RFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9601:ARNTL
gene id: 9601:ARNTL
uniprot id: A0A2J8UQ19
uniprot id: A0A2J8UQ31
uniprot id: Q5R4T2
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-537 by CLOCK during the repression phase of the circadian cycle. Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle. Acetylated at Lys-537 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts. Deacetylated by SIRT1, which may result in decreased protein stability.
messages: Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (By similarity). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (By similarity). Interacts with NPAS2 (By similarity). Interacts with EZH2 (By similarity). Interacts with SUMO3 (By similarity). Interacts with SIRT1 (By similarity). Interacts with AHR (By similarity). Interacts with ID1, ID2 and ID3 (By similarity). Interacts with DDX4 (By similarity). Interacts with OGT (By similarity). Interacts with EED and SUZ12 (By similarity). Interacts with MTA1 (By similarity). Interacts with CIART (By similarity). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (By similarity). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with UBE3A (By similarity). Interacts with PRKCG (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1 (By similarity)…
messages: Cytoplasm
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.
messages: PML body
messages: Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity.
messages: Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP9X.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.

9601:MRPL47
gene id: 9601:MRPL47
uniprot id: H2PC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9601:MIS18A
gene id: 9601:MIS18A
uniprot id: H2P2Y8
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9601:ZNF583
gene id: 9601:ZNF583
uniprot id: A0A6D2WFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:GGCX
gene id: 9601:GGCX
uniprot id: Q5RF50
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the vitamin K-dependent gamma-carboxylase family.
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Monomer (By similarity). May interact with CALU (By similarity).
messages: The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates.

9601:SRSF10
gene id: 9601:SRSF10
uniprot id: A0A2J8SJ00
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PEX7
gene id: 9601:PEX7
uniprot id: H2PKF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

9601:CCDC92
gene id: 9601:CCDC92
uniprot id: A0A2J8XIZ5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:EZR
gene id: 9601:EZR
uniprot id: A0A6D2XPS5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9601:ACOX3
gene id: 9601:ACOX3
uniprot id: Q5RAU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
messages: Peroxisome

9601:CFHR2
gene id: 9601:CFHR2
uniprot id: H2N4B1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:LOC100442963
gene id: 9601:LOC100442963
uniprot id: A0A2J8TRS5
names: Caution
names: Similarity
messages: Belongs to the Bcl-2 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:POLR2D
gene id: 9601:POLR2D
uniprot id: A0A6D2Y218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9601:NPM3
gene id: 9601:NPM3
uniprot id: A0A2J8XYE4
uniprot id: Q5RC37
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoplasmin family.
messages: Interacts with NPM (via N-terminus). Forms a pentamer with NPM at a ratio 4:1 (NPM3/NPM). Two pentamers form a decamer.
messages: Nucleus
messages: Phosphorylated.
messages: Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:DNAJB6
gene id: 9601:DNAJB6
uniprot id: Q5R8H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
messages: Homooligomer. Interacts with BAG3, HSPB8 and STUB1 (By similarity). Interacts with ALKBH1 (By similarity). Interacts with HSP70, KRT18 and PTTG (By similarity).
messages: Nucleus
messages: Z line
messages: perinuclear region

9601:SMARCE1
gene id: 9601:SMARCE1
uniprot id: A0A2J8WAG1
uniprot id: A0A6D2Y3E7
uniprot id: A0A803KJ12
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ELK3
gene id: 9601:ELK3
uniprot id: H2NIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:PUF60
gene id: 9601:PUF60
uniprot id: Q5R469
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM half pint family.
messages: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA (By similarity).
messages: Homodimer (By similarity). Associates with the spliceosome (By similarity). Found in a complex with RO60 and Y5 RNA (By similarity). Found in a complex with FUBP1 and far upstream element (FUSE) DNA segment (By similarity). Interacts directly with ERCC3 (By similarity). Interacts with CDK7 and GTF2H1 (By similarity). Interacts with SRSF11/P54 (By similarity).
messages: Nucleus
messages: The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions.

9601:HOXB13
gene id: 9601:HOXB13
uniprot id: H2NVI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9601:TOMM7
gene id: 9601:TOMM7
uniprot id: H2PMP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9601:LOC100462147
gene id: 9601:LOC100462147
uniprot id: A0A6D2WUC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9601:WDR20
gene id: 9601:WDR20
uniprot id: A0A2J8SZQ8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYSM1
gene id: 9601:MYSM1
uniprot id: H2N786
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

9601:CHRNB3
gene id: 9601:CHRNB3
uniprot id: H2PQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:ZNF136
gene id: 9601:ZNF136
uniprot id: Q5REK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.
messages: Nucleus

9601:PCLAF
gene id: 9601:PCLAF
uniprot id: A0A2J8T8B3
uniprot id: A0A6D2XYF4
uniprot id: H2NNG9
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9601:PAX7
gene id: 9601:PAX7
uniprot id: A0A2J8T289
uniprot id: A0A2J8T290
uniprot id: H2N8U5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100459213
gene id: 9601:LOC100459213
uniprot id: A0A2J8TJU5
names: Caution
names: Similarity
messages: Belongs to the sulfotransferase 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RRM2B
gene id: 9601:RRM2B
uniprot id: A0A2J8UFL5
uniprot id: Q5R9G0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm
messages: Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage (By similarity).
messages: Nucleus
messages: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity).
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100459812
gene id: 9601:LOC100459812
uniprot id: H2NK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9601:ELF2
gene id: 9601:ELF2
uniprot id: A0A2J8XP86
uniprot id: H2PEC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ARGLU1
gene id: 9601:ARGLU1
uniprot id: H2NKA0
names: Similarity
messages: Belongs to the UPF0430 family.

9601:LOC100443389
gene id: 9601:LOC100443389
uniprot id: A0A8I5TSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9601:AMOTL1
gene id: 9601:AMOTL1
uniprot id: A0A2J8XWM3
uniprot id: H2NF02
names: Similarity
messages: Belongs to the angiomotin family.

9601:FIBP
gene id: 9601:FIBP
uniprot id: A0A2J8TZQ2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MYCN
gene id: 9601:MYCN
uniprot id: A0A2J8V478
uniprot id: H2P6X2
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CLRN3
gene id: 9601:CLRN3
uniprot id: H2NBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9601:ALKBH6
gene id: 9601:ALKBH6
uniprot id: A0A2J8RRX3
uniprot id: K7EVL5
names: Similarity
messages: Belongs to the alkB family.

9601:LOC100449389
gene id: 9601:LOC100449389
uniprot id: A0A6D2XNQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:LOC100456423
gene id: 9601:LOC100456423
uniprot id: A0A2J8SSJ1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRSS55
gene id: 9601:PRSS55
uniprot id: A0A663DAV1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:C9H9orf153
gene id: 9601:C9H9orf153
uniprot id: A0A6D2XAZ7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PLA2G1B
gene id: 9601:PLA2G1B
uniprot id: H2NIV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9601:LOC100452112
gene id: 9601:LOC100452112
uniprot id: A0A663DHS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GPR61
gene id: 9601:GPR61
uniprot id: A0A6D2WEN6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:FNIP2
gene id: 9601:FNIP2
uniprot id: H2PEM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9601:TAGLN3
gene id: 9601:TAGLN3
uniprot id: Q5R6R2
names: Similarity
messages: Belongs to the calponin family.

9601:OTOP3
gene id: 9601:OTOP3
uniprot id: A0A663DCT6
uniprot id: H2NUN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GALNT18
gene id: 9601:GALNT18
uniprot id: H2NE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9601:LOC100458340
gene id: 9601:LOC100458340
uniprot id: H2NIT0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9601:LOC100447911
gene id: 9601:LOC100447911
uniprot id: A0A2J8RSH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CEPT1
gene id: 9601:CEPT1
uniprot id: A0A6D2WG37
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9601:SLC23A1
gene id: 9601:SLC23A1
uniprot id: A0A803KGY4
uniprot id: Q5RE01
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SPEM1
gene id: 9601:SPEM1
uniprot id: H2NSJ3
names: Subcellular Location Annotation
messages: Membrane

9601:TUT1
gene id: 9601:TUT1
uniprot id: Q5RE94
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

9601:ELP4
gene id: 9601:ELP4
uniprot id: A0A2J8WGI0
uniprot id: A0A6D2XUR0
uniprot id: H2NDS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:YTHDF3
gene id: 9601:YTHDF3
uniprot id: A0A2J8UR49
uniprot id: Q5RFL8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YTHDF family. YTHDF3 subfamily.
messages: Interacts with CNOT1; promoting recruitment of the CCR4-NOT complex. Interacts with YTHDF1. Interacts with YTHDF2 (By similarity). Interacts with PAN3 (By similarity).
messages: P-body
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (By similarity). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity).
messages: Stress granule
messages: The disordered regions have the ability to interact with each other and to 'phase separate' into liquid droplets within the cytosol following binding to mRNAs containing multiple m6A-modified residues. This leads to the partition of m6A-containing mRNAs into membraneless compartments, where mRNAs may be stored, degraded or used to transport mRNAs to dendritic arbors in neurons.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytosol

9601:TSC22D1
gene id: 9601:TSC22D1
uniprot id: A0A2J8VSQ0
uniprot id: A0A2J8VST3
uniprot id: Q5R4H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Cytoplasm
messages: Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).

9601:PLOD1
gene id: 9601:PLOD1
uniprot id: Q5R9N3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). Identified in a complex with P3H3 and P3H4 (By similarity).
messages: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity).
messages: Rough endoplasmic reticulum membrane

9601:ZHX2
gene id: 9601:ZHX2
uniprot id: Q5R7F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
messages: Belongs to the ZHX family.
messages: Homodimer (via homeobox domain 1). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX3 (via homeobox domain 1). Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity.
messages: Nucleus

9601:ACTL9
gene id: 9601:ACTL9
uniprot id: A0A6D2X9L4
names: Similarity
messages: Belongs to the actin family.

9601:TSPYL1
gene id: 9601:TSPYL1
uniprot id: Q5R5G8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg-Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation.
messages: nucleolus

9601:PECR
gene id: 9601:PECR
uniprot id: A0A2J8STU4
uniprot id: Q5RCH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Interacts with PEX5, probably required to target it into peroxisomes.
messages: Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
messages: Peroxisome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:UPP1
gene id: 9601:UPP1
uniprot id: A0A6D2XQ50
uniprot id: A0A8I5TBM1
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9601:SMARCD3
gene id: 9601:SMARCD3
uniprot id: A0A663DDD2
names: Similarity
messages: Belongs to the SMARCD family.

9601:HLX
gene id: 9601:HLX
uniprot id: H2N3N3
names: Subcellular Location Annotation
messages: Nucleus

9601:UGDH
gene id: 9601:UGDH
uniprot id: A0A6D2Y7K7
uniprot id: Q5R7B3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity).
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
messages: The allosteric switch region moves by about 5 Angstroms when UDP-xylose is bound, and occupies part of the UDP-glucose binding site. At the same time it promotes domain movements that disrupt the active hexameric ring structure and lead to the formation of a horseshoe-shaped, inactive hexamer.
messages: The protein goes through several conformation states during the reaction cycle, giving rise to hysteresis. In the initial state, the ligand-free protein is in an inactive conformation (E*). Substrate binding triggers a change to the active conformation (E). UDP-xylose binding triggers the transition to a distinct, inhibited conformation. The presence of an intrinsically disordered C-terminus promotes a more dynamic protein structure and favors a conformation with high affinity for UPD-xylose.
messages: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor. It binds at the same site as the substrate, but functions as allosteric inhibitor by triggering a conformation change that disrupts the active hexameric ring structure and gives rise to an inactive, horseshoe-shaped hexamer.

9601:UBQLN1
gene id: 9601:UBQLN1
uniprot id: Q5R684
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Degraded during both macroautophagy and during chaperone-mediated autophagy (CMA).
messages: Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.
messages: Endoplasmic reticulum
messages: Monomer and homodimer. Heterodimer with UBQLN2. Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3. Binds UBE3A, BTRC, P4HB and MTOR. Interacts with the proteasome 19S subunit. Interacts (via ubiquitin-like domain) with TREX1; the interaction is direct and may control TREX1 subcellular location. Forms a complex with UBXN4 and VCP. Interacts (via UBA domain) with UBQLN4 (via ubiquitin-like domain). Found in a complex with UBQLN2 and MAP1LC3A/B/C. The monomeric form interacts with PSEN1 and PSEN2. Interacts with ORAI1. Interacts (via UBA domain) with TICAM1. Interacts with EPS15. Interacts (via UBA domain) with UBA52 and (via ubiquitin-like domain) with PSMD3 and PSMD4. Interacts with HERPUD1. Interacts with MAP1LC3A/B/C in the presence of UBQLN4. Interacts (via ubiquitin-like domain) with EPS15 (via UIM domains) and both the ubiquitinated and non-ubiquitinated forms can interact with EPS15. Interacts (via ubiquitin-like domain) with EPS15L1, HGS (via UIM domain) and STAM2 (via UIM domain) (By similarity). Interacts with BCL2L10/BCL-B; in the cytoplasm (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization. Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing. Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (By similarity).
messages: The UBA domain mediates binding to PSEN1 and PSEN2. It also binds ubiquitin with micromolar affinity, independently of polyubiquitin linkage type. Essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3).
messages: The ubiquitin-like domain mediates its association with the subunits of the proteasome.
messages: Ubiquitinated.
messages: autophagosome

9601:CMTM8
gene id: 9601:CMTM8
uniprot id: H2PB95
names: Subcellular Location Annotation
messages: Membrane

9601:APC
gene id: 9601:APC
uniprot id: H2PG96
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9601:SERP1
gene id: 9601:SERP1
uniprot id: Q5REZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).
messages: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).
messages: Membrane

9601:MMP20
gene id: 9601:MMP20
uniprot id: H2NF32
names: Similarity
messages: Belongs to the peptidase M10A family.

9601:LOC100450413
gene id: 9601:LOC100450413
uniprot id: A0A8I5TEM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9601:GHSR
gene id: 9601:GHSR
uniprot id: H2PC06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9601:BCR
gene id: 9601:BCR
uniprot id: H2P3R7
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9601:NFIB
gene id: 9601:NFIB
uniprot id: A0A2J8XI05
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PRKG2
gene id: 9601:PRKG2
uniprot id: A0A2J8UUJ0
uniprot id: A0A6D2W0L5
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SRP14
gene id: 9601:SRP14
uniprot id: Q5RBX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).

9601:KIF19
gene id: 9601:KIF19
uniprot id: H2NUL4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9601:CHSY3
gene id: 9601:CHSY3
uniprot id: Q5R852
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9601:LAYN
gene id: 9601:LAYN
uniprot id: A0A6D2Y2L4
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PCSK5
gene id: 9601:PCSK5
uniprot id: A0A2J8SU84
uniprot id: A0A2J8SUA0
names: Similarity
messages: Belongs to the peptidase S8 family.

9601:LNPK
gene id: 9601:LNPK
uniprot id: Q5R891
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes.
messages: Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-217, Ser-227, Ser-321 and Ser-384 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-353 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.
messages: Subject to proteasomal degradation following phosphorylation during mitosis.
messages: The transmembrane domain 1 and 2 function as a signal-anchor and stop-transfer sequence, respectively, generating a double-spanning integral membrane protein with a N- and C-terminal cytoplasmic orientation. Transmembrane domain 1 and 2 are probably sufficient to mediate membrane translocation and topology formation in a N-myristoylation-independent manner. Transmembrane domain 2 is sufficient to block the protein secretion pathway. The two coiled-coil domains are necessary for its endoplasmic reticulum (ER) three-way tubular junction localization. The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9601:CTNNB1
gene id: 9601:CTNNB1
uniprot id: A0A6D2XVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9601:NELFCD
gene id: 9601:NELFCD
uniprot id: Q5RFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NELF-D family.
messages: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).
messages: Nucleus
messages: The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (By similarity). Binds RNA which may help to stabilize the NELF complex on nucleic acid (By similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (By similarity). Interacts with ARAF1 (By similarity). Interacts with PCF11 (By similarity). Interacts with NELFB (By similarity). Interacts with KAT8 (By similarity).

9601:SLC9A7
gene id: 9601:SLC9A7
uniprot id: H2PVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9601:UCKL1
gene id: 9601:UCKL1
uniprot id: H2P2N5
names: Similarity
messages: Belongs to the uridine kinase family.

9601:LOC100439906
gene id: 9601:LOC100439906
uniprot id: H2NTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9601:PIWIL4
gene id: 9601:PIWIL4
uniprot id: H2NF00
names: Similarity
messages: Belongs to the argonaute family.

9601:DNAJC22
gene id: 9601:DNAJC22
uniprot id: A0A6D2VTQ3
uniprot id: Q5RBD7
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9601:SGSM3
gene id: 9601:SGSM3
uniprot id: Q5RBJ4
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9601:BMP8B
gene id: 9601:BMP8B
uniprot id: H2N7V4
names: Similarity
messages: Belongs to the TGF-beta family.

9601:IL33
gene id: 9601:IL33
uniprot id: A0A2J8XHT2
uniprot id: Q5RDG8
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity).
messages: Cytoplasm
messages: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity).
messages: Nucleus
messages: Secreted
messages: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity).
messages: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Vesicle
messages: secretory vesicle

9601:SPCS2
gene id: 9601:SPCS2
uniprot id: A0A2J8V191
uniprot id: Q5RAY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CASQ1
gene id: 9601:CASQ1
uniprot id: H2N552
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9601:AP2B1
gene id: 9601:AP2B1
uniprot id: Q5R7H7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9601:IFI27L1
gene id: 9601:IFI27L1
uniprot id: A0A2J8TLW7
uniprot id: A0A6D2XKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9601:SQSTM1
gene id: 9601:SQSTM1
uniprot id: Q5RBA5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes. Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (By similarity). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity).
messages: Endoplasmic reticulum
messages: Homooligomer or heterooligomer; may form homotypic arrays. Interacts directly with PRKCI and PRKCZ (Probable). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM13, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 probably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with AJUBA, PRKCZ and TRAF6. Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. Identified in a heterotrimeric complex with ubiquitin and ZFAND5, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Directly interacts with MAP1LC3A and MAP1LC3B, as well as with other MAP1 LC3 family members, including GABARAP, GABARAPL1 and GABARAPL2; these interactions are necessary for the recruitment MAP1 LC3 family members to inclusion bodies containing polyubiquitinated protein aggregates and for their degradation by autophagy (By similarity). Interacts with FHOD3 (By similarity). Interacts with TRMI5 (By similarity). Interacts with SESN1 (By similarity). Interacts with SESN2 (By similarity). Interacts with ULK1. Interacts with UBD (By similarity). Interacts with WDR81; the interaction is direct and regulates the interaction of SQSTM1 with ubiquitinated proteins (By similarity). Interacts with WDFY3; this interaction is required to recruit WDFY3 to cytoplasmic bodies and to PML bodies (By similarity). Interacts with TRIM50 (By similarity). Interacts with TR…
messages: Late endosome
messages: Lysosome
messages: Nucleus
messages: PML body
messages: Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN. Phosphorylation at Ser-403 by ULK1 is stimulated by SESN2 (By similarity). Phosphorylated at Ser-403 by TBK1, leading to promote relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Phosphorylation at Ser-349 by MTOR promotes interaction with KEAP1 and inactivation of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity).
messages: Preautophagosomal structure
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: The PB1 domain mediates homooligomerization and interactions with FHOD3, MAP2K5, NBR1, PRKCI, PRKCZ and WDR81. Both the PB1 and UBA domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies.
messages: The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55. Both the UBA and PB1 domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies.
messages: The ZZ-type zinc finger mediates the interaction with RIPK1.
messages: Ubiquitinated by UBE2J1 and RNF26 at Lys-435: ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Deubiquitination by USP15 releases target vesicles for fast transport into the cell periphery. Ubiquitinated by the BCR(KEAP1) complex at Lys-420, increasing SQSTM1 sequestering activity and promoting its degradation. Ubiquitinated via 'Lys-29' and 'Lys-33'-linked polyubiquitination leading to xenophagic targeting of bacteria and inhibition of their replication.
messages: autophagosome
messages: cytosol
messages: sarcomere

9601:SUCLA2
gene id: 9601:SUCLA2
uniprot id: Q5R6V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9601:C12H12orf65
gene id: 9601:C12H12orf65
uniprot id: A0A6D2XWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9601:INTS3
gene id: 9601:INTS3
uniprot id: Q5RE70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 3 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1.
messages: Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
messages: Cytoplasm
messages: Nucleus

9601:CHRNA3
gene id: 9601:CHRNA3
uniprot id: A0A2J8SKF3
uniprot id: A0A6D2Y7D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9601:TPM2
gene id: 9601:TPM2
uniprot id: A0A2J8T0D6
uniprot id: A0A2J8T0D9
uniprot id: A0A6D2WXX7
uniprot id: A0A8I5T6B8
uniprot id: H2PRS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: cytoskeleton

9601:SYNE4
gene id: 9601:SYNE4
uniprot id: H2NYJ3
names: Similarity
messages: Belongs to the nesprin family.

9601:GPR55
gene id: 9601:GPR55
uniprot id: A0A6D2XML8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9601:VPS26C
gene id: 9601:VPS26C
uniprot id: A0A2J8UAF9
uniprot id: Q5RF33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L. Interacts with SNX17; the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.
messages: Endosome
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LETMD1
gene id: 9601:LETMD1
uniprot id: A0A2J8SXW5
uniprot id: A0A663DJ52
uniprot id: H2NHA8
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PPP1R2
gene id: 9601:PPP1R2
uniprot id: H2PCF1
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9601:LHX9
gene id: 9601:LHX9
uniprot id: A0A6D2XV37
uniprot id: H2N4A3
names: Subcellular Location Annotation
messages: Nucleus

9601:LOC100445036
gene id: 9601:LOC100445036
uniprot id: A0A8I5U1R4
names: Similarity
messages: Belongs to the intermediate filament family.

9601:MAPK14
gene id: 9601:MAPK14
uniprot id: A0A2J8Y3G6
uniprot id: A0A663DEM3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9601:WDR45B
gene id: 9601:WDR45B
uniprot id: Q5R7W0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway.
messages: Interacts with the TSC1-TSC2 complex; stimulated upon starvation. Interacts with RB1CC1.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

9601:TIMM17B
gene id: 9601:TIMM17B
uniprot id: A0A6D2WJY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:WLS
gene id: 9601:WLS
uniprot id: Q5R9R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the wntless family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A.
messages: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

9601:NAT6
gene id: 9601:NAT6
uniprot id: A0A2J8TGX3
uniprot id: A0A2J8TH68
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MMS22L
gene id: 9601:MMS22L
uniprot id: H2PJV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9601:TMEM30A
gene id: 9601:TMEM30A
uniprot id: Q5RA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

9601:SERPINE3
gene id: 9601:SERPINE3
uniprot id: A0A2J8VS65
uniprot id: A0A2J8VS98
names: Similarity
messages: Belongs to the serpin family.

9601:MED31
gene id: 9601:MED31
uniprot id: A0A2J8RXG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9601:CTSO
gene id: 9601:CTSO
uniprot id: H2PEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9601:MYH2
gene id: 9601:MYH2
uniprot id: A0A6D2XB89
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9601:SPIN4
gene id: 9601:SPIN4
uniprot id: A0A6D2WK79
names: Similarity
messages: Belongs to the SPIN/STSY family.

9601:ZNF438
gene id: 9601:ZNF438
uniprot id: Q5RC05
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor.
messages: Nucleus

9601:GRM3
gene id: 9601:GRM3
uniprot id: Q5RAL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity).
messages: Interacts with TAMALIN.

9601:DLX5
gene id: 9601:DLX5
uniprot id: H2PMV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9601:C2AH2orf49
gene id: 9601:C2AH2orf49
uniprot id: A0A2J8S9I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9601:TREX1
gene id: 9601:TREX1
uniprot id: H2PAU7
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9601:TRPM7
gene id: 9601:TRPM7
uniprot id: A0A663DEA5
uniprot id: H2NN79
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ADAMTS8
gene id: 9601:ADAMTS8
uniprot id: H2NFY5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9601:NDUFAF2
gene id: 9601:NDUFAF2
uniprot id: H2PFM7
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9601:ITFG2
gene id: 9601:ITFG2
uniprot id: Q5RBH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
messages: Lysosome membrane
messages: Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complex in an amino acid-independent manner.

9601:EVA1A
gene id: 9601:EVA1A
uniprot id: A0A2J8SEZ2
names: Similarity
messages: Belongs to the EVA1 family.

9601:ACVR1B
gene id: 9601:ACVR1B
uniprot id: A0A2J8SXN8
uniprot id: A0A6D2VSG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LYSMD1
gene id: 9601:LYSMD1
uniprot id: A0A2J8VF10
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:AMD1
gene id: 9601:AMD1
uniprot id: A0A6D2XPJ6
uniprot id: H2PK22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PFKL
gene id: 9601:PFKL
uniprot id: Q5R7V5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. GlcNAcylation by OGT overcomes allosteric regulation (By similarity).
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).
messages: Cytoplasm
messages: GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation (By similarity).
messages: Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable).

9601:IRGC
gene id: 9601:IRGC
uniprot id: H2NZ36
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9601:RAB39B
gene id: 9601:RAB39B
uniprot id: A0A6D2X1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9601:C1R
gene id: 9601:C1R
uniprot id: Q5R544
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds (By similarity).
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9601:PIK3C3
gene id: 9601:PIK3C3
uniprot id: A0A2J8XFL8
uniprot id: A0A6D2VUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9601:LGR5
gene id: 9601:LGR5
uniprot id: H2NI23
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9601:FAM214B
gene id: 9601:FAM214B
uniprot id: A0A2J8T0M3
uniprot id: Q5RBA3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Belongs to the FAM214 family.
messages: Nucleus
messages: The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: Transcription regulator that may syncronize transcriptional and translational programs.

9601:MUC13
gene id: 9601:MUC13
uniprot id: H2P9I2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9601:MARCH7
gene id: 9601:MARCH7
uniprot id: Q5R9W2
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (By similarity).
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

9601:FAXDC2
gene id: 9601:FAXDC2
uniprot id: A0A6D2XJU3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CEP57
gene id: 9601:CEP57
uniprot id: A0A6D2XCM1
uniprot id: H2NF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Belongs to the translokin family.
messages: Cytoplasm

9601:LOC100453006
gene id: 9601:LOC100453006
uniprot id: A0A6D2VSM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SEPT4
gene id: 9601:SEPT4
uniprot id: Q5R6R7
uniprot id: Q5R7Y5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity).
messages: Perikaryon
messages: Phosphorylated by DYRK1A.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPTIN8 (By similarity). Component of a septin core octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 (By similarity). Interacts with SEPTIN14 (via C-terminus) (By similarity). Interacts with DYRK1A (By similarity). Interacts with SLC6A3/DAT and SNCA/alpha-synuclein (By similarity). Interacts with STX1A; in the striatum (By similarity). Interacts with XIAP (via BIR3 domain) following the induction of apoptosis (By similarity). Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (By similarity).
messages: Synapse
messages: Ubiquitinated by AREL1.
messages: axon
messages: dendrite
messages: flagellum
messages: secretory vesicle

9601:ELP1
gene id: 9601:ELP1
uniprot id: Q5RDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Cytoplasm

9601:NT5DC3
gene id: 9601:NT5DC3
uniprot id: H2NIF9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9601:MFAP3
gene id: 9601:MFAP3
uniprot id: A0A2J8X6G7
uniprot id: Q5R9E4
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of the elastin-associated microfibrils.
messages: Glycosylated.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:TCP11
gene id: 9601:TCP11
uniprot id: A0A2J8Y387
uniprot id: A0A2J8Y3D8
names: Caution
names: Similarity
messages: Belongs to the TCP11 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:IL12A
gene id: 9601:IL12A
uniprot id: H2PBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9601:HMGN3
gene id: 9601:HMGN3
uniprot id: A0A2J8V2F0
uniprot id: A0A2J8V2F9
uniprot id: H2PJM8
uniprot id: Q5R715
uniprot id: Q5RCS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with transcriptional regulator SEHBP. Interacts with nucleosomes.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100432153
gene id: 9601:LOC100432153
uniprot id: A0A2J8XIS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9601:HVCN1
gene id: 9601:HVCN1
uniprot id: A0A6D2WYN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9601:GALNT4
gene id: 9601:GALNT4
uniprot id: A0A2J8XND2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DHX15
gene id: 9601:DHX15
uniprot id: Q5RAZ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is enhanced upon binding to G-patch domain-containing proteins. G-patch domain-containing proteins act like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity, thereby promoting the ATPase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Identified in the Intron Large spliceosome complex (IL, also named intron lariat spliceosome), a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. The IL complex exists in two distinct conformations, one with the DHX15 (ILS2) and one without (ILS1). Interacts with TFIP11 (via G-patch domain); indicative for a recruitment to the IL complex. Interacts with SSB/La. Interacts with GPATCH2 (via G-patch domain); promoting the RNA helicase activity. Interacts with NKRF (via G-patch domain); promoting the RNA helicase activity. Interacts with NLRP6.
messages: Nucleus
messages: RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses. The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (By similarity). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).
messages: nucleolus

9601:FAM110B
gene id: 9601:FAM110B
uniprot id: A0A2J8UQU1
uniprot id: Q5R5R3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM110 family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: centrosome

9601:OLFML3
gene id: 9601:OLFML3
uniprot id: H2N6B0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9601:MGP
gene id: 9601:MGP
uniprot id: Q5RDP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation (By similarity).
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9601:GSC
gene id: 9601:GSC
uniprot id: H2NM59
names: Subcellular Location Annotation
messages: Nucleus

9601:DPH2
gene id: 9601:DPH2
uniprot id: A0A2J8SM52
uniprot id: Q5RE82
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with DPH1 (By similarity).
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:SENP2
gene id: 9601:SENP2
uniprot id: Q5R7K7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C48 family.
messages: Binds to SUMO2 and SUMO3. Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.
messages: Cytoplasm
messages: Nucleus membrane
messages: Polyubiquitinated; which leads to proteasomal degradation.
messages: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
messages: The N-terminus is necessary and sufficient for nuclear envelope targeting.
messages: nuclear pore complex

9601:AGPAT4
gene id: 9601:AGPAT4
uniprot id: H2PKT6
uniprot id: Q5R757
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9601:ZNF84
gene id: 9601:ZNF84
uniprot id: A0A2J8RAV2
uniprot id: Q5R7I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:GATB
gene id: 9601:GATB
uniprot id: H2PEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9601:ENPP2
gene id: 9601:ENPP2
uniprot id: A0A2J8X2W4
uniprot id: A0A2J8X2W5
uniprot id: A0A2J8X2Z1
uniprot id: Q5R6E5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CABS1
gene id: 9601:CABS1
uniprot id: H2PDH9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9601:SERPINB11
gene id: 9601:SERPINB11
uniprot id: A0A2J8W3N7
names: Similarity
messages: Belongs to the serpin family.

9601:TGM3
gene id: 9601:TGM3
uniprot id: H2P1F0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9601:FSTL1
gene id: 9601:FSTL1
uniprot id: Q5R9Y1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). Interacts with SCN10A (By similarity). Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1. Interacts with BMP4. Interacts with CD14; this interaction promotes TL4-mediated signaling cascade (By similarity).
messages: Secreted
messages: Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).

9601:ELP6
gene id: 9601:ELP6
uniprot id: H2PAW4
names: Similarity
messages: Belongs to the ELP6 family.

9601:HRH4
gene id: 9601:HRH4
uniprot id: A0A2J8XGJ6
uniprot id: H2NW27
names: Caution
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:DACT1
gene id: 9601:DACT1
uniprot id: A0A2J8WLC8
uniprot id: H2NLD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZNF641
gene id: 9601:ZNF641
uniprot id: A0A2J8WD56
uniprot id: A0A6D2X1V9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PACSIN2
gene id: 9601:PACSIN2
uniprot id: Q5R7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9601:LOC100442186
gene id: 9601:LOC100442186
uniprot id: H2NJ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:IDH2
gene id: 9601:IDH2
uniprot id: A0A2J8VX59
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9601:PPM1D
gene id: 9601:PPM1D
uniprot id: H2NUD3
names: Similarity
messages: Belongs to the PP2C family.

9601:C2AH2orf40
gene id: 9601:C2AH2orf40
uniprot id: A0A663D793
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9601:PGLYRP2
gene id: 9601:PGLYRP2
uniprot id: H2NXW7
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9601:CCNI2
gene id: 9601:CCNI2
uniprot id: A0A2J8XDN5
uniprot id: H2PGI7
names: Caution
names: Similarity
messages: Belongs to the cyclin family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:LOC100445875
gene id: 9601:LOC100445875
uniprot id: A0A6D2XQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:PLTP
gene id: 9601:PLTP
uniprot id: Q5RCP9
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9601:ADAMTS4
gene id: 9601:ADAMTS4
uniprot id: H2N516
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9601:POP5
gene id: 9601:POP5
uniprot id: A0A2J8XJZ7
uniprot id: H2NIW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: nucleolus

9601:SLC17A1
gene id: 9601:SLC17A1
uniprot id: A0A6D2XMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9601:SHMT1
gene id: 9601:SHMT1
uniprot id: Q5RFK5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Homotetramer. Identified in complex with ABRAXAS2 and the other subunits of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.

9601:CRYGA
gene id: 9601:CRYGA
uniprot id: H2P8F8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9601:VARS2
gene id: 9601:VARS2
uniprot id: A0A663D5W5
uniprot id: H2PIG7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9601:RAD18
gene id: 9601:RAD18
uniprot id: Q5RAZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9601:GIMAP4
gene id: 9601:GIMAP4
uniprot id: A0A2J8RK36
uniprot id: A0A663D680
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:RBPJL
gene id: 9601:RBPJL
uniprot id: A4K2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9601:OGDHL
gene id: 9601:OGDHL
uniprot id: Q5R9L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH. The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (By similarity).
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Mitochondrion matrix
messages: The OGDHC complex comprises multiple copies of three catalytic enzyme components, the 2-oxoglutarate dehydrogenase (OGDH/E1), the dihydrolipoamide dehydrogenase (DLST/E2) and the dihydrolipoamide dehydrogenase (DLD/E3). OGDHL/E1-like isoenzyme may replace OGDH in the OGDHC complex in the brain. The presence of either ODGH/E1 or ODGHL/E1-like isoenzyme in the complex may depend on its tissular distribution.

9601:LOC100447858
gene id: 9601:LOC100447858
uniprot id: H2N344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:SPRY4
gene id: 9601:SPRY4
uniprot id: A0A2J8VNY8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:GAPDH
gene id: 9601:GAPDH
uniprot id: A0A6D2WJ05
uniprot id: Q5RAB4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).
messages: Homotetramer.
messages: ISGylated.
messages: Nucleus
messages: Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.
messages: S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
messages: Sulfhydration at Cys-152 increases catalytic activity.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: cytosol

9601:SLC2A3
gene id: 9601:SLC2A3
uniprot id: Q5R608
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9601:LOC100438841
gene id: 9601:LOC100438841
uniprot id: A0A2J8R820
names: Caution
names: Similarity
messages: Belongs to the SMEK family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:KLHL3
gene id: 9601:KLHL3
uniprot id: Q5REP9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 (By similarity). Interacts with SLC12A3 (By similarity). Interacts with WNK1 and WNK4 (By similarity). Interacts with CLDN8 (By similarity).
messages: Phosphorylation at Ser-433 by PKA decreases the interaction with WNK4, Leading to inhibit WNK4 degradation by the BCR(KLHL3) complex. Phosphorylation at Ser-433 is increased by insulin.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
messages: cytoskeleton
messages: cytosol

9601:CCDC198
gene id: 9601:CCDC198
uniprot id: A0A2J8WL69
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:PABPC1
gene id: 9601:PABPC1
uniprot id: Q5R8F7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability.
messages: Cytoplasm
messages: May form homodimers. Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Directly interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with PAIP1 and PAIP2 (via the PABPC1-interacting motifs PAM1 and PAM2). Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction with CSDE1 is direct and RNA-independent (By similarity). Found in a mRNP complex with YBX2. Interacts with TENT2/GLD2 (By similarity). Identified in the spliceosome C complex. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. The interaction with DDX3X is direct and RNA-independent. This interaction increases in stressed cells and decreases during cell recovery. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NXF1/TAP (By similarity). Interacts with PIWIL1 (By similarity). Interacts with AGO1, AGO2, GSPT1 and GSPT2. Interacts with LARP4B. Interacts (via the second and third RRM domains and the C-terminus) with PAIP2B (via central acidic portion and C-terminus). Forms a complex with LARP1 and SHFL. Interacts with LARP4. Interacts with ZFC3H1 in a RNase-sensitive manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function. Interacts with G3BP1 and G3BP2 (By similarity). Interacts with ENDOV; the interaction is RNA-dependent and stimulates ENDOV activity (By similarity). Interacts with UPF1; the interaction is RNA-dependent (By similarity). Interacts with IGF2BP2 and IGF2BP3. May interact with SETX.
messages: Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine (By similarity).
messages: Nucleus
messages: Phosphorylated by MAPKAPK2.
messages: Stress granule
messages: The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact respectively with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively.
messages: The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively.
messages: lamellipodium

9601:CDC45
gene id: 9601:CDC45
uniprot id: A0A2J8RBH7
uniprot id: A0A2J8RBI7
uniprot id: A0A6D2Y4B3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MGST1
gene id: 9601:MGST1
uniprot id: A0A2J8T1L0
uniprot id: A0A6D2W942
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9601:SPIB
gene id: 9601:SPIB
uniprot id: A0A8I5UYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9601:SLFN5
gene id: 9601:SLFN5
uniprot id: H2NTD0
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9601:BCLAF1
gene id: 9601:BCLAF1
uniprot id: A0A2J8X9J8
uniprot id: A0A2J8X9K4
uniprot id: H2PKE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCLAF1/THRAP3 family.
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:BMP2
gene id: 9601:BMP2
uniprot id: H2P103
names: Similarity
messages: Belongs to the TGF-beta family.

9601:NRM
gene id: 9601:NRM
uniprot id: A0A6D2XYD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9601:NNMT
gene id: 9601:NNMT
uniprot id: A0A6D2XYP1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9601:ZNF302
gene id: 9601:ZNF302
uniprot id: Q5R8B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9601:EIF1AD
gene id: 9601:EIF1AD
uniprot id: A0A2J8TZT3
uniprot id: Q5RD29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Nucleus
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:STK33
gene id: 9601:STK33
uniprot id: A0A2J8SVB3
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:CUL2
gene id: 9601:CUL2
uniprot id: A0A2J8U366
uniprot id: Q5RCF3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and a variable substrate-specific adapter. Component of the ECS(VHL) or CBC(VHL) complex containing VHL. Component of the ECS(MED8) complex with the probable substrate recognition component MED8. Component of multiple ECS complexes part of the DesCEND (destruction via C-end degrons) pathway, which contain either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component. Component of the ECS(LRR1) complex with the probable substrate recognition component LRR1. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC. Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1. Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation. Component of VCB (elongins BC/CUL2/VHL) complex that contains at least DCUN1D1, CUL2 and VHL; this complex triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation.
messages: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity).
messages: Neddylated; which enhances the ubiquitination activity of ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:ZFP37
gene id: 9601:ZFP37
uniprot id: A0A2J8WRV2
uniprot id: A0A2J8WRZ4
uniprot id: H2PT34
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:MAEL
gene id: 9601:MAEL
uniprot id: A0A6D2X6C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9601:LOC100460430
gene id: 9601:LOC100460430
uniprot id: A0A6D2XBG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9601:FAM206A
gene id: 9601:FAM206A
uniprot id: A0A2J8WS40
uniprot id: Q5RFS0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
messages: Belongs to the ABITRAM family.
messages: Interacts with F-actin (By similarity). Interacts with G-actin (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The name derives from simia, latin, a female ape, and M, A, T and E, the first four amino acids of the ape orthologs.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
messages: dendrite
messages: growth cone
messages: lamellipodium

9601:USP1
gene id: 9601:USP1
uniprot id: A0A6D2XF17
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9601:SMR3B
gene id: 9601:SMR3B
uniprot id: A0A6D2WA57
names: Subcellular Location Annotation
messages: Secreted

9601:GPATCH11
gene id: 9601:GPATCH11
uniprot id: H2P6H8
names: Similarity
messages: Belongs to the GPATCH11 family.

9601:AICDA
gene id: 9601:AICDA
uniprot id: A0A2J8TC35
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

9601:VPS4B
gene id: 9601:VPS4B
uniprot id: Q5R658
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses).
messages: Belongs to the AAA ATPase family.
messages: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
messages: Late endosome membrane
messages: Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner. In vitro, associates on the inside of a helical tubular structure formed by a CHMP2A-CHMP3 polymer. Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP4B and CHMP6. Interacts with VPS4A; the interaction suggests a heteromeric assembly with VPS4A. Interacts with VTA1 (By similarity).
messages: The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2).