9597:PRPSAP1
gene id: 9597:PRPSAP1
uniprot id: A0A2R9ANY8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9597:NT5C3B
gene id: 9597:NT5C3B
uniprot id: A0A2R9B9B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9597:SKAP2
gene id: 9597:SKAP2
uniprot id: A0A2R9AI38
names: Similarity
messages: Belongs to the SKAP family.

9597:FAR2
gene id: 9597:FAR2
uniprot id: A0A2R9BUJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9597:PTGS1
gene id: 9597:PTGS1
uniprot id: A0A2R8ZUM0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:STX7
gene id: 9597:STX7
uniprot id: A0A2R8ZQ90
names: Similarity
messages: Belongs to the syntaxin family.

9597:TM4SF4
gene id: 9597:TM4SF4
uniprot id: A0A2R9C7E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9597:POLR3F
gene id: 9597:POLR3F
uniprot id: A0A2R9BKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9597:TRAPPC6A
gene id: 9597:TRAPPC6A
uniprot id: A0A2R8ZVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9597:CDK2
gene id: 9597:CDK2
uniprot id: A0A2R9B4E4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:B4GALT2
gene id: 9597:B4GALT2
uniprot id: A0A2R9BWS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:THBS4
gene id: 9597:THBS4
uniprot id: A0A2R9B1Q9
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZIC4
gene id: 9597:ZIC4
uniprot id: A0A2R9BGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9597:SHMT2
gene id: 9597:SHMT2
uniprot id: A0A2R9AVY3
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9597:SLC25A45
gene id: 9597:SLC25A45
uniprot id: A0A2R9B3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:RPL27
gene id: 9597:RPL27
uniprot id: A0A2R8ZYE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9597:EIF3D
gene id: 9597:EIF3D
uniprot id: A0A2R9AH19
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9597:UBE2U
gene id: 9597:UBE2U
uniprot id: A0A2R9BXE8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:LOC100972396
gene id: 9597:LOC100972396
uniprot id: A0A2R9APS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TIGD6
gene id: 9597:TIGD6
uniprot id: A0A2R8ZA19
names: Subcellular Location Annotation
messages: Nucleus

9597:DESI1
gene id: 9597:DESI1
uniprot id: A0A2R9B6Y9
names: Similarity
messages: Belongs to the DeSI family.

9597:GLE1
gene id: 9597:GLE1
uniprot id: A0A2R9AY79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9597:MCMBP
gene id: 9597:MCMBP
uniprot id: A0A2R9C673
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9597:RPL39
gene id: 9597:RPL39
uniprot id: A0A2R9CE33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9597:KIF12
gene id: 9597:KIF12
uniprot id: A0A2R9C130
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:XPOT
gene id: 9597:XPOT
uniprot id: A0A2R9AGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9597:ALPI
gene id: 9597:ALPI
uniprot id: A0A2R9AW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9597:PFKM
gene id: 9597:PFKM
uniprot id: A0A2R9BRB6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PTPRD
gene id: 9597:PTPRD
uniprot id: A0A2R9AQW8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9597:CPSF2
gene id: 9597:CPSF2
uniprot id: A0A2R9BVW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9597:KRT73
gene id: 9597:KRT73
uniprot id: A0A2R9BRC5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:NEMP1
gene id: 9597:NEMP1
uniprot id: A0A2R9AMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9597:KYNU
gene id: 9597:KYNU
uniprot id: A0A2R8ZE77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TNFSF13B
gene id: 9597:TNFSF13B
uniprot id: A0A2R8ZNW2
uniprot id: A0A2R8ZQJ1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:SLC27A2
gene id: 9597:SLC27A2
uniprot id: A0A2R9CFT6
uniprot id: A0A2R9CIF1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:TMEM98
gene id: 9597:TMEM98
uniprot id: A0A2R9BGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9597:RPS14
gene id: 9597:RPS14
uniprot id: A0A2R8ZV22
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9597:P2RX4
gene id: 9597:P2RX4
uniprot id: A0A2R9CK77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:TXK
gene id: 9597:TXK
uniprot id: A0A2R9BH56
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:LECT2
gene id: 9597:LECT2
uniprot id: A0A2R8Z767
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9597:PSMD4
gene id: 9597:PSMD4
uniprot id: A0A2R9AIV2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9597:TATDN3
gene id: 9597:TATDN3
uniprot id: A0A2R9BJF7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9597:GCM2
gene id: 9597:GCM2
uniprot id: A0A2R9BES7
names: Subcellular Location Annotation
messages: Nucleus

9597:RGS2
gene id: 9597:RGS2
uniprot id: A0A2R9BEH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9597:LOC100979729
gene id: 9597:LOC100979729
uniprot id: A0A2R8ZBG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:BORA
gene id: 9597:BORA
uniprot id: A0A2R9B312
uniprot id: A0A2R9B5B9
names: Similarity
messages: Belongs to the BORA family.

9597:CDH9
gene id: 9597:CDH9
uniprot id: A0A2R9AV11
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:ZPBP
gene id: 9597:ZPBP
uniprot id: A0A2R9AF12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9597:ADAMTS4
gene id: 9597:ADAMTS4
uniprot id: A0A2R9CI30
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:HEXIM1
gene id: 9597:HEXIM1
uniprot id: A0A2R8ZEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9597:KRT40
gene id: 9597:KRT40
uniprot id: A0A2R9AGR7
names: Similarity
messages: Belongs to the intermediate filament family.

9597:AGPAT3
gene id: 9597:AGPAT3
uniprot id: A0A2R9AA44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TSC22D3
gene id: 9597:TSC22D3
uniprot id: A0A2R9BW34
uniprot id: A0A2R9C5T0
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9597:TYROBP
gene id: 9597:TYROBP
uniprot id: A0A2R9C1E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9597:WASHC5
gene id: 9597:WASHC5
uniprot id: A0A2R9BF54
names: Similarity
messages: Belongs to the strumpellin family.

9597:SH3BP5L
gene id: 9597:SH3BP5L
uniprot id: A0A2R9APA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9597:ZNF596
gene id: 9597:ZNF596
uniprot id: A0A2R8ZDM2
names: Function
messages: May be involved in transcriptional regulation.

9597:PARP6
gene id: 9597:PARP6
uniprot id: A0A2R9CPY3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:OSBPL8
gene id: 9597:OSBPL8
uniprot id: A0A2R9CL40
names: Similarity
messages: Belongs to the OSBP family.

9597:STC2
gene id: 9597:STC2
uniprot id: A0A2R9CC17
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9597:MCPH1
gene id: 9597:MCPH1
uniprot id: A0A2R8ZCB3
uniprot id: A0A2R8ZGA3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9597:NKAP
gene id: 9597:NKAP
uniprot id: A0A2R9AHB2
names: Similarity
messages: Belongs to the NKAP family.

9597:CRH
gene id: 9597:CRH
uniprot id: A0A2R8ZPS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9597:JUP
gene id: 9597:JUP
uniprot id: A0A2R9C352
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9597:AP1G1
gene id: 9597:AP1G1
uniprot id: A0A2R9AGR9
uniprot id: A0A2R9ANN7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:GJC1
gene id: 9597:GJC1
uniprot id: A0A2R8ZCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:SLC9C2
gene id: 9597:SLC9C2
uniprot id: A0A2R9A6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9597:GFM1
gene id: 9597:GFM1
uniprot id: A0A2R9AW37
uniprot id: A0A2R9B001
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9597:MCIDAS
gene id: 9597:MCIDAS
uniprot id: A0A2R9B0E3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9597:SCGB1D2
gene id: 9597:SCGB1D2
uniprot id: A0A2R8ZCD0
names: Subcellular Location Annotation
messages: Secreted

9597:SCNN1G
gene id: 9597:SCNN1G
uniprot id: A0A2R8ZRP1
names: Subcellular Location Annotation
messages: Membrane

9597:PIGW
gene id: 9597:PIGW
uniprot id: A0A2R8ZPP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9597:RIDA
gene id: 9597:RIDA
uniprot id: A0A2R9ABI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9597:ATP6V1E2
gene id: 9597:ATP6V1E2
uniprot id: A0A2R9ARI0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9597:ZNF174
gene id: 9597:ZNF174
uniprot id: A0A2R9ASF3
names: Subcellular Location Annotation
messages: Nucleus

9597:PAX8
gene id: 9597:PAX8
uniprot id: A0A2R9AHH6
names: Subcellular Location Annotation
messages: Nucleus

9597:GCH1
gene id: 9597:GCH1
uniprot id: A0A2R9C157
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9597:IL12A
gene id: 9597:IL12A
uniprot id: A0A2R9BQY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9597:LDB2
gene id: 9597:LDB2
uniprot id: A0A2R9ATR9
names: Similarity
messages: Belongs to the LDB family.

9597:DIS3
gene id: 9597:DIS3
uniprot id: A0A2R9C8K9
uniprot id: A0A2R9CB13
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9597:HYAL3
gene id: 9597:HYAL3
uniprot id: A0A2R9BA36
uniprot id: A0A2R9BCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Membrane
messages: acrosome

9597:SPRR2B
gene id: 9597:SPRR2B
uniprot id: A0A2R8ZGR6
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9597:SGCD
gene id: 9597:SGCD
uniprot id: A0A2R8ZV78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9597:KIF21B
gene id: 9597:KIF21B
uniprot id: A0A2R9C367
uniprot id: A0A2R9C5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9597:DGKG
gene id: 9597:DGKG
uniprot id: A0A2R9AY61
uniprot id: A0A2R9B257
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9597:POPDC3
gene id: 9597:POPDC3
uniprot id: A0A2R9ALV6
names: Similarity
messages: Belongs to the popeye family.

9597:FAM110C
gene id: 9597:FAM110C
uniprot id: A0A2R9AB80
names: Similarity
messages: Belongs to the FAM110 family.

9597:VAMP7
gene id: 9597:VAMP7
uniprot id: A0A2R9ATW9
uniprot id: A0A2R9AW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:SMOC2
gene id: 9597:SMOC2
uniprot id: A0A2R9BJ17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ATG7
gene id: 9597:ATG7
uniprot id: A0A2R9C9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9597:SEC62
gene id: 9597:SEC62
uniprot id: A0A2R9BU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:VSNL1
gene id: 9597:VSNL1
uniprot id: A0A2R9AQ19
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9597:TOR2A
gene id: 9597:TOR2A
uniprot id: A0A2R9C7V2
uniprot id: A0A2R9CIE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9597:F2RL2
gene id: 9597:F2RL2
uniprot id: A0A2R9BBE2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC100994750
gene id: 9597:LOC100994750
uniprot id: A0A2R8ZCB5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:AMIGO2
gene id: 9597:AMIGO2
uniprot id: A0A2R8ZJY3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9597:FAM155A
gene id: 9597:FAM155A
uniprot id: A0A2R8ZJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9597:TIMM13
gene id: 9597:TIMM13
uniprot id: A0A2R9B7J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:TUBA1C
gene id: 9597:TUBA1C
uniprot id: A0A2R9ASI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9597:TNFRSF25
gene id: 9597:TNFRSF25
uniprot id: A0A2R9BER1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:UTP25
gene id: 9597:UTP25
uniprot id: A0A2R9CJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9597:TARS1
gene id: 9597:TARS1
uniprot id: A0A2R8ZJH6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:AMY2B
gene id: 9597:AMY2B
uniprot id: A0A2R8ZUK3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9597:CDC45
gene id: 9597:CDC45
uniprot id: A0A2R9A6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9597:PARP16
gene id: 9597:PARP16
uniprot id: A0A2R9AA47
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:SLC17A9
gene id: 9597:SLC17A9
uniprot id: A0A2R8ZFI7
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100988443
gene id: 9597:LOC100988443
uniprot id: A0A2R9BB48
names: Function
messages: May be involved in transcriptional regulation.

9597:CBS
gene id: 9597:CBS
uniprot id: A0A2R9CEY1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9597:ELOVL1
gene id: 9597:ELOVL1
uniprot id: A0A2R9CDD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:VPS26C
gene id: 9597:VPS26C
uniprot id: A0A2R9ABU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9597:ACER1
gene id: 9597:ACER1
uniprot id: A0A2R9C7X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9597:GRK3
gene id: 9597:GRK3
uniprot id: A0A2R9A3T4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:FTMT
gene id: 9597:FTMT
uniprot id: A0A2R8ZN40
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9597:MAST4
gene id: 9597:MAST4
uniprot id: A0A2R8ZBS7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9597:ZNF221
gene id: 9597:ZNF221
uniprot id: A0A2R9A814
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC25A41
gene id: 9597:SLC25A41
uniprot id: A0A2R9BEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:MTCP1
gene id: 9597:MTCP1
uniprot id: A0A2R9A4E0
names: Similarity
messages: Belongs to the TCL1 family.

9597:LOC100993427
gene id: 9597:LOC100993427
uniprot id: A0A2R9BCS2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9597:PCYT1B
gene id: 9597:PCYT1B
uniprot id: A0A2R8ZXA1
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9597:LBX2
gene id: 9597:LBX2
uniprot id: A0A2R9BXD3
names: Subcellular Location Annotation
messages: Nucleus

9597:AVIL
gene id: 9597:AVIL
uniprot id: A0A2R9CR49
names: Similarity
messages: Belongs to the villin/gelsolin family.

9597:PDE6G
gene id: 9597:PDE6G
uniprot id: A0A2R9A364
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9597:VPS37C
gene id: 9597:VPS37C
uniprot id: A0A2R9AQ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:LOC100983853
gene id: 9597:LOC100983853
uniprot id: A0A2R9AN18
names: Similarity
messages: Belongs to the amidase family.

9597:PNP
gene id: 9597:PNP
uniprot id: A0A2R8ZI70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9597:ABCG5
gene id: 9597:ABCG5
uniprot id: A0A2R8ZSC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9597:LXN
gene id: 9597:LXN
uniprot id: A0A2R9CAF3
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9597:CD40LG
gene id: 9597:CD40LG
uniprot id: A0A2R9CD52
uniprot id: A0A2R9CD61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9597:TIMM8B
gene id: 9597:TIMM8B
uniprot id: A0A2R9B6T3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:PROM1
gene id: 9597:PROM1
uniprot id: A0A2R9AWA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9597:PEMT
gene id: 9597:PEMT
uniprot id: A0A2R8Z718
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9597:NOL6
gene id: 9597:NOL6
uniprot id: A0A2R9C5Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9597:FZD4
gene id: 9597:FZD4
uniprot id: A0A2R9BZZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9597:AKAP8
gene id: 9597:AKAP8
uniprot id: A0A2R9B909
names: Similarity
messages: Belongs to the AKAP95 family.

9597:MTFMT
gene id: 9597:MTFMT
uniprot id: A0A2R9B368
names: Similarity
messages: Belongs to the Fmt family.

9597:ARL4D
gene id: 9597:ARL4D
uniprot id: A0A2R8ZRG5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:NKD2
gene id: 9597:NKD2
uniprot id: A0A2R9AZU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9597:GLA
gene id: 9597:GLA
uniprot id: A0A2R9A2F5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9597:XCR1
gene id: 9597:XCR1
uniprot id: A0A2R8Z9R7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC100967723
gene id: 9597:LOC100967723
uniprot id: A0A2R9BAA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9597:MTHFD1
gene id: 9597:MTHFD1
uniprot id: A0A2R8ZEG2
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9597:POLG2
gene id: 9597:POLG2
uniprot id: A0A2R9AS12
names: Subcellular Location Annotation
messages: Mitochondrion

9597:TBXAS1
gene id: 9597:TBXAS1
uniprot id: A0A2R9A342
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:LOC100985913
gene id: 9597:LOC100985913
uniprot id: A0A2R8ZF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:HBP1
gene id: 9597:HBP1
uniprot id: A0A2R9CA46
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9597:SMU1
gene id: 9597:SMU1
uniprot id: A0A2R9AQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9597:CNR2
gene id: 9597:CNR2
uniprot id: A0A2R8ZE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:STING1
gene id: 9597:STING1
uniprot id: A0A2R9ALQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9597:STX10
gene id: 9597:STX10
uniprot id: A0A2R9CA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9597:CFAP97D1
gene id: 9597:CFAP97D1
uniprot id: A0A2R9AZX8
names: Similarity
messages: Belongs to the CFAP97 family.

9597:MEP1B
gene id: 9597:MEP1B
uniprot id: A0A2R8ZFM8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:EIF2B1
gene id: 9597:EIF2B1
uniprot id: A0A2R8ZMT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9597:SLC22A7
gene id: 9597:SLC22A7
uniprot id: A0A2R9BNG5
uniprot id: A0A2R9BP63
names: Subcellular Location Annotation
messages: Membrane

9597:RELT
gene id: 9597:RELT
uniprot id: A0A2R9AKJ8
names: Similarity
messages: Belongs to the RELT family.

9597:L3MBTL2
gene id: 9597:L3MBTL2
uniprot id: A0A2R9C1E1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9597:ZC3HAV1
gene id: 9597:ZC3HAV1
uniprot id: A0A2R9BSP8
uniprot id: B0LB04
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:S100A8
gene id: 9597:S100A8
uniprot id: A0A2R9C7E2
names: Similarity
messages: Belongs to the S-100 family.

9597:LOC100987845
gene id: 9597:LOC100987845
uniprot id: A0A2R9A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9597:SEC24D
gene id: 9597:SEC24D
uniprot id: A0A2R9A1R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:ALKBH1
gene id: 9597:ALKBH1
uniprot id: A0A2R9C7C9
names: Similarity
messages: Belongs to the alkB family.

9597:FBL
gene id: 9597:FBL
uniprot id: A0A2R9B441
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9597:SCN4A
gene id: 9597:SCN4A
uniprot id: A0A2R9BN28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9597:PLA2G4D
gene id: 9597:PLA2G4D
uniprot id: A0A2R9BZ19
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9597:MFF
gene id: 9597:MFF
uniprot id: A0A2R9CEZ4
uniprot id: A0A2R9CF37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9597:P2RX1
gene id: 9597:P2RX1
uniprot id: A0A2R9AHU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:CPN1
gene id: 9597:CPN1
uniprot id: A0A2R9CHK1
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:LOC100975217
gene id: 9597:LOC100975217
uniprot id: A0A2R8ZEF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PPFIBP2
gene id: 9597:PPFIBP2
uniprot id: A0A2R9C2G1
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9597:PKMYT1
gene id: 9597:PKMYT1
uniprot id: A0A2R9BCZ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:SIX6
gene id: 9597:SIX6
uniprot id: A0A2R9CLP7
names: Subcellular Location Annotation
messages: Nucleus

9597:CHAF1B
gene id: 9597:CHAF1B
uniprot id: A0A2R9ACU3
names: Subcellular Location Annotation
messages: Nucleus

9597:KRT6A
gene id: 9597:KRT6A
uniprot id: A0A2R9B125
names: Similarity
messages: Belongs to the intermediate filament family.

9597:HS2ST1
gene id: 9597:HS2ST1
uniprot id: A0A2R9BUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9597:GIMAP7
gene id: 9597:GIMAP7
uniprot id: A0A2R8ZHS2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:EFTUD2
gene id: 9597:EFTUD2
uniprot id: A0A2R9AB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9597:CYP3A43
gene id: 9597:CYP3A43
uniprot id: A0A2R8ZKP7
uniprot id: A0A2R8ZLS0
uniprot id: A0A2R8ZNI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:RBM48
gene id: 9597:RBM48
uniprot id: A0A2R9BU12
names: Similarity
messages: Belongs to the RBM48 family.

9597:GJB2
gene id: 9597:GJB2
uniprot id: A0A2R8ZIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:DNM1L
gene id: 9597:DNM1L
uniprot id: A0A2R9BXC8
uniprot id: A0A2R9C0R1
uniprot id: A0A2R9C0R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

9597:FABP6
gene id: 9597:FABP6
uniprot id: A0A2R9CCH1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:UBE2A
gene id: 9597:UBE2A
uniprot id: A0A2R8Z7N0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:LSS
gene id: 9597:LSS
uniprot id: A0A2R9B2H2
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

9597:LOC100980803
gene id: 9597:LOC100980803
uniprot id: A0A2R8ZFE4
names: Similarity
messages: Belongs to the ATG8 family.

9597:LOC100989678
gene id: 9597:LOC100989678
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:NR4A2
gene id: 9597:NR4A2
uniprot id: A0A2R9AK54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9597:MRPL3
gene id: 9597:MRPL3
uniprot id: A0A2R8ZF57
uniprot id: A0A2R8ZLM9
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9597:POMT1
gene id: 9597:POMT1
uniprot id: A0A2R8ZUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9597:PCK1
gene id: 9597:PCK1
uniprot id: A0A2R9BLN9
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9597:CTSB
gene id: 9597:CTSB
uniprot id: A0A2R9A6B0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:APOA2
gene id: 9597:APOA2
uniprot id: P0DM95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A2 family.
messages: Homodimer; disulfide-linked (PubMed:21298813). Interacts with NAXE and NDRG1 (By similarity).
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Plasma.
messages: Secreted

9597:RPL18
gene id: 9597:RPL18
uniprot id: A0A2R8ZFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9597:CLCA1
gene id: 9597:CLCA1
uniprot id: A0A2R9CPF6
names: Similarity
messages: Belongs to the CLCR family.

9597:APIP
gene id: 9597:APIP
uniprot id: A0A2R9B3W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9597:IMMP1L
gene id: 9597:IMMP1L
uniprot id: A0A2R9CKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9597:NSUN2
gene id: 9597:NSUN2
uniprot id: A0A2R9B8T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9597:LOC100984553
gene id: 9597:LOC100984553
uniprot id: A0A2R9AJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ST8SIA3
gene id: 9597:ST8SIA3
uniprot id: A0A2R8ZQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LOC103786029
gene id: 9597:LOC103786029
uniprot id: A0A2R8ZUE3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:CAMK2N1
gene id: 9597:CAMK2N1
uniprot id: A0A2R9CHD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9597:PIGH
gene id: 9597:PIGH
uniprot id: A0A2R9C3M8
names: Similarity
messages: Belongs to the PIGH family.

9597:ZC3H12B
gene id: 9597:ZC3H12B
uniprot id: A0A2R9C444
names: Similarity
messages: Belongs to the ZC3H12 family.

9597:DYNLL2
gene id: 9597:DYNLL2
uniprot id: A0A2R9ASN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9597:CTNNB1
gene id: 9597:CTNNB1
uniprot id: A0A2R9BC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9597:SFTPD
gene id: 9597:SFTPD
uniprot id: A0A2R9BYW6
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9597:HAPLN1
gene id: 9597:HAPLN1
uniprot id: A0A2R9BLD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100981677
gene id: 9597:LOC100981677
uniprot id: A0A2R8ZCQ5
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9597:DLX5
gene id: 9597:DLX5
uniprot id: A0A2R9ALQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9597:CLUAP1
gene id: 9597:CLUAP1
uniprot id: A0A2R8ZXU7
uniprot id: A0A2R9A1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9597:EMC6
gene id: 9597:EMC6
uniprot id: A0A2R8ZPJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100989488
gene id: 9597:LOC100989488
uniprot id: A0A2R8ZIT4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:HADHA
gene id: 9597:HADHA
uniprot id: A0A2R9CMA4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9597:SNRPD1
gene id: 9597:SNRPD1
uniprot id: A0A2R9CD13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9597:HS3ST5
gene id: 9597:HS3ST5
uniprot id: A0A2R8ZRJ5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:TP73
gene id: 9597:TP73
uniprot id: A0A2R9BEB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Nucleus

9597:HDAC1
gene id: 9597:HDAC1
uniprot id: A0A2R9AMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9597:MFSD11
gene id: 9597:MFSD11
uniprot id: A0A2R9CD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9597:VAMP5
gene id: 9597:VAMP5
uniprot id: A0A2R9AEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:FGF13
gene id: 9597:FGF13
uniprot id: A0A2R9BAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9597:IPO9
gene id: 9597:IPO9
uniprot id: A0A2R9BK65
names: Subcellular Location Annotation
messages: Cytoplasm

9597:METTL15
gene id: 9597:METTL15
uniprot id: A0A2R9A2B6
uniprot id: A0A2R9A2C6
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9597:PPP2R5A
gene id: 9597:PPP2R5A
uniprot id: A0A2R8ZLU4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:MC5R
gene id: 9597:MC5R
uniprot id: A0A2R8Z6X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9597:PSMB4
gene id: 9597:PSMB4
uniprot id: A0A2R9AAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9597:ATP2B2
gene id: 9597:ATP2B2
uniprot id: A0A2R9CH85
uniprot id: A0A2R9CK00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TNFSF8
gene id: 9597:TNFSF8
uniprot id: A0A2R9CJ75
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:MTMR9
gene id: 9597:MTMR9
uniprot id: A0A2R8ZTD2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:LOC100988637
gene id: 9597:LOC100988637
uniprot id: A0A2R9BFT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RAP2B
gene id: 9597:RAP2B
uniprot id: A0A2R8ZU86
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9597:DPPA5
gene id: 9597:DPPA5
uniprot id: A0A2R9B3Q3
names: Similarity
messages: Belongs to the KHDC1 family.

9597:PACSIN2
gene id: 9597:PACSIN2
uniprot id: A0A2R9BEV2
uniprot id: A0A2R9BHF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9597:CYP2A13
gene id: 9597:CYP2A13
uniprot id: A0A2R8ZAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:ALKBH2
gene id: 9597:ALKBH2
uniprot id: A0A2R9AWD5
names: Similarity
messages: Belongs to the alkB family.

9597:UXT
gene id: 9597:UXT
uniprot id: A0A2R9A7R1
names: Similarity
messages: Belongs to the UXT family.

9597:ACRBP
gene id: 9597:ACRBP
uniprot id: A0A2R9CE14
names: Subcellular Location Annotation
messages: acrosome

9597:CPB2
gene id: 9597:CPB2
uniprot id: A0A2R9AX42
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:HPS6
gene id: 9597:HPS6
uniprot id: A0A2R8ZCG4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9597:LOC100994595
gene id: 9597:LOC100994595
uniprot id: A0A2R8ZLQ1
names: Similarity
messages: Belongs to the TAPR1 family.

9597:STARD5
gene id: 9597:STARD5
uniprot id: A0A2R9C3H0
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9597:HMGB3
gene id: 9597:HMGB3
uniprot id: A0A2R9BT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9597:SLC25A32
gene id: 9597:SLC25A32
uniprot id: A0A2R9C2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:WDR48
gene id: 9597:WDR48
uniprot id: A0A2R9ADG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9597:TAGLN3
gene id: 9597:TAGLN3
uniprot id: A0A2R9BSF0
names: Similarity
messages: Belongs to the calponin family.

9597:PARN
gene id: 9597:PARN
uniprot id: A0A2R9APG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9597:ZFP69
gene id: 9597:ZFP69
uniprot id: A0A2R9A6H0
names: Function
messages: May be involved in transcriptional regulation.

9597:CHMP5
gene id: 9597:CHMP5
uniprot id: A0A2R9AXJ7
names: Similarity
messages: Belongs to the SNF7 family.

9597:ATP8B2
gene id: 9597:ATP8B2
uniprot id: A0A2R9AX67
uniprot id: A0A2R9AX93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:HYOU1
gene id: 9597:HYOU1
uniprot id: A0A2R8ZB00
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9597:LYPD5
gene id: 9597:LYPD5
uniprot id: A0A2R9ABL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:IL9
gene id: 9597:IL9
uniprot id: A0A2R9ANX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9597:ZNF396
gene id: 9597:ZNF396
uniprot id: A0A2R8ZJL8
names: Subcellular Location Annotation
messages: Nucleus

9597:YAE1
gene id: 9597:YAE1
uniprot id: A0A2R8ZYI0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:LOC100988315
gene id: 9597:LOC100988315
uniprot id: A0A2R8ZWF1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:NDRG1
gene id: 9597:NDRG1
uniprot id: A0A2R8ZLB2
names: Similarity
messages: Belongs to the NDRG family.

9597:LOC106635329
gene id: 9597:LOC106635329
uniprot id: A0A2R8Z624
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:DPM1
gene id: 9597:DPM1
uniprot id: A0A2R9CPW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9597:DDAH1
gene id: 9597:DDAH1
uniprot id: A0A2R9ATQ6
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9597:CASQ1
gene id: 9597:CASQ1
uniprot id: A0A2R9AKL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9597:E2F8
gene id: 9597:E2F8
uniprot id: A0A2R9B864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:SPTBN1
gene id: 9597:SPTBN1
uniprot id: A0A2R8ZQ01
uniprot id: A0A2R8ZQ14
names: Similarity
messages: Belongs to the spectrin family.

9597:COQ8A
gene id: 9597:COQ8A
uniprot id: A0A2R9BPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9597:NKAPL
gene id: 9597:NKAPL
uniprot id: A0A2R8ZU93
names: Similarity
messages: Belongs to the NKAP family.

9597:LOC100978567
gene id: 9597:LOC100978567
uniprot id: A0A2R8ZLC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:POLB
gene id: 9597:POLB
uniprot id: A0A2R8ZGI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9597:ANKZF1
gene id: 9597:ANKZF1
uniprot id: A0A2R9AIQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9597:PDK4
gene id: 9597:PDK4
uniprot id: A0A2R8ZSG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9597:RPL8
gene id: 9597:RPL8
uniprot id: A0A2R9C8R8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9597:CD5L
gene id: 9597:CD5L
uniprot id: A0A2R9CA56
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LYZL1
gene id: 9597:LYZL1
uniprot id: A0A2R9A1K3
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9597:WNT2
gene id: 9597:WNT2
uniprot id: A0A2R9AB51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:MOB3A
gene id: 9597:MOB3A
uniprot id: A0A2R9C2K8
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:LOC100970534
gene id: 9597:LOC100970534
uniprot id: A0A2R9B892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9597:NEMF
gene id: 9597:NEMF
uniprot id: A0A2R9ASD9
names: Similarity
messages: Belongs to the NEMF family.

9597:SFXN4
gene id: 9597:SFXN4
uniprot id: A0A2R9B6S0
uniprot id: A0A2R9B890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9597:LOC100985290
gene id: 9597:LOC100985290
uniprot id: A0A2R8ZF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9597:NKAIN2
gene id: 9597:NKAIN2
uniprot id: A0A2R8Z9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9597:CNIH3
gene id: 9597:CNIH3
uniprot id: A0A2R9CBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9597:LOC100983724
gene id: 9597:LOC100983724
uniprot id: A0A2R9APD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FUT4
gene id: 9597:FUT4
uniprot id: A0A2R8ZQQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9597:MDH2
gene id: 9597:MDH2
uniprot id: A0A2R9AZI0
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9597:IFNA8
gene id: 9597:IFNA8
uniprot id: A0A2R8ZIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:SLC44A3
gene id: 9597:SLC44A3
uniprot id: A0A2R9BQR5
uniprot id: A0A2R9BRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9597:ASPDH
gene id: 9597:ASPDH
uniprot id: A0A2R9A749
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9597:SRD5A2
gene id: 9597:SRD5A2
uniprot id: A0A2R9ANP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9597:PTGER4
gene id: 9597:PTGER4
uniprot id: A0A2R9A7J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9597:LGALS3
gene id: 9597:LGALS3
uniprot id: A0A2R9AZ94
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:NDUFB9
gene id: 9597:NDUFB9
uniprot id: A0A2R9BV43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:LOC100970246
gene id: 9597:LOC100970246
uniprot id: A0A2R9BHJ3
names: Function
messages: May be involved in transcriptional regulation.

9597:NGB
gene id: 9597:NGB
uniprot id: A0A2R9C3L3
names: Similarity
messages: Belongs to the globin family.

9597:LOC100972973
gene id: 9597:LOC100972973
uniprot id: A0A2R8Z9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:THEMIS
gene id: 9597:THEMIS
uniprot id: A0A2R9AW99
names: Similarity
messages: Belongs to the themis family.

9597:AXIN2
gene id: 9597:AXIN2
uniprot id: A0A2R9AXD3
uniprot id: A0A2R9AXL2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:CA12
gene id: 9597:CA12
uniprot id: A0A2R9CJN5
uniprot id: A0A2R9CMB8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9597:LOC106634652
gene id: 9597:LOC106634652
uniprot id: A0A2R8Z6E0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:ODC1
gene id: 9597:ODC1
uniprot id: A0A2R8ZEL7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9597:SLC2A8
gene id: 9597:SLC2A8
uniprot id: A0A2R9AB25
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9597:CPO
gene id: 9597:CPO
uniprot id: A0A2R9AYB1
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:OSBPL11
gene id: 9597:OSBPL11
uniprot id: A0A2R9BCN3
names: Similarity
messages: Belongs to the OSBP family.

9597:LOC100968071
gene id: 9597:LOC100968071
uniprot id: A0A2R9CFF5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9597:GTF2H5
gene id: 9597:GTF2H5
uniprot id: A0A2R9CDD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9597:NTMT1
gene id: 9597:NTMT1
uniprot id: A0A2R9BLQ4
uniprot id: A0A2R9BQA2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9597:COPS9
gene id: 9597:COPS9
uniprot id: A0A2R9BW14
names: Similarity
messages: Belongs to the CSN9 family.

9597:ECSIT
gene id: 9597:ECSIT
uniprot id: A0A2R9BGV4
uniprot id: A0A2R9BHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9597:SLC48A1
gene id: 9597:SLC48A1
uniprot id: A0A2R9C8S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9597:ELOVL3
gene id: 9597:ELOVL3
uniprot id: A0A2R9C1K2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:RND3
gene id: 9597:RND3
uniprot id: A0A2R9CCZ2
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9597:TAP2
gene id: 9597:TAP2
uniprot id: A0A2R9AWW1
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9597:ROS1
gene id: 9597:ROS1
uniprot id: A0A2R9C2C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9597:ARID1A
gene id: 9597:ARID1A
uniprot id: A0A2R9B7U2
names: Subcellular Location Annotation
messages: Nucleus

9597:SAP130
gene id: 9597:SAP130
uniprot id: A0A2R9BNT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9597:SERINC4
gene id: 9597:SERINC4
uniprot id: A0A2R9ARN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9597:TMEM106B
gene id: 9597:TMEM106B
uniprot id: A0A2R9ABQ4
names: Similarity
messages: Belongs to the TMEM106 family.

9597:CBLB
gene id: 9597:CBLB
uniprot id: A0A2R9AMN4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9597:N4BP3
gene id: 9597:N4BP3
uniprot id: A0A2R8ZSP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9597:PSMD2
gene id: 9597:PSMD2
uniprot id: A0A2R9BE76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9597:NELFCD
gene id: 9597:NELFCD
uniprot id: A0A2R9CH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9597:EFNA1
gene id: 9597:EFNA1
uniprot id: A0A2R8ZSH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LOC106634091
gene id: 9597:LOC106634091
uniprot id: A0A2R8ZPL7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:CDC42
gene id: 9597:CDC42
uniprot id: A0A2R9AF88
uniprot id: A0A2R9AG93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9597:LOC100971814
gene id: 9597:LOC100971814
uniprot id: A0A2R8Z5R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PRRX1
gene id: 9597:PRRX1
uniprot id: A0A2R9AGJ6
uniprot id: A0A2R9AKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:LOC100991079
gene id: 9597:LOC100991079
uniprot id: A0A2R8ZFM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9597:GTF2A1L
gene id: 9597:GTF2A1L
uniprot id: A0A2R8ZQN9
uniprot id: A0A2R8ZRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9597:YME1L1
gene id: 9597:YME1L1
uniprot id: A0A2R9C161
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9597:ART1
gene id: 9597:ART1
uniprot id: A0A2R9A8F9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9597:ARPP19
gene id: 9597:ARPP19
uniprot id: A0A2R9B6P2
uniprot id: A0A2R9B860
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9597:EFEMP1
gene id: 9597:EFEMP1
uniprot id: A0A2R9AUY9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NF2
gene id: 9597:NF2
uniprot id: A0A2R9AF69
uniprot id: A0A2R9ALW4
uniprot id: A0A2R9ALW9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:AVPI1
gene id: 9597:AVPI1
uniprot id: A0A2R9ARR5
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9597:ZNF112
gene id: 9597:ZNF112
uniprot id: A0A2R9C319
uniprot id: A0A2R9CA15
names: Function
messages: May be involved in transcriptional regulation.

9597:TSPAN18
gene id: 9597:TSPAN18
uniprot id: A0A2R9AHT9
uniprot id: A0A2R9AMI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:MRPL32
gene id: 9597:MRPL32
uniprot id: A0A2R9BSZ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9597:RDM1
gene id: 9597:RDM1
uniprot id: A0A2R9A9K3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9597:ADGRL2
gene id: 9597:ADGRL2
uniprot id: A0A2R8ZV82
uniprot id: A0A2R8ZWF7
uniprot id: A0A2R9A0W1
names: Subcellular Location Annotation
messages: Membrane

9597:ACO2
gene id: 9597:ACO2
uniprot id: A0A2R8ZLD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9597:TUBGCP4
gene id: 9597:TUBGCP4
uniprot id: A0A2R8ZMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9597:CIBAR2
gene id: 9597:CIBAR2
uniprot id: A0A2R9A3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9597:SEPSECS
gene id: 9597:SEPSECS
uniprot id: A0A2R9BML0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9597:TEC
gene id: 9597:TEC
uniprot id: A0A2R9AFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:RPL15
gene id: 9597:RPL15
uniprot id: A0A2R9ARX9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9597:AP5M1
gene id: 9597:AP5M1
uniprot id: A0A2R9CB95
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9597:LOC100990238
gene id: 9597:LOC100990238
uniprot id: A0A2R9BG39
uniprot id: A0A2R9BG43
uniprot id: A0A2R9BG57
names: Subcellular Location Annotation
messages: cilium

9597:WASF1
gene id: 9597:WASF1
uniprot id: A0A2R8Z8I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9597:ANKRD13C
gene id: 9597:ANKRD13C
uniprot id: A0A2R9B0Y8
names: Subcellular Location Annotation
messages: Membrane

9597:CBX8
gene id: 9597:CBX8
uniprot id: A0A2R9A1E3
names: Subcellular Location Annotation
messages: Nucleus

9597:LAMB3
gene id: 9597:LAMB3
uniprot id: A0A2R9A5F9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MOSPD1
gene id: 9597:MOSPD1
uniprot id: A0A2R9AHI8
uniprot id: A0A2R9AM97
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9597:LOC100971372
gene id: 9597:LOC100971372
uniprot id: A0A2R8ZE55
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9597:HHIP
gene id: 9597:HHIP
uniprot id: A0A2R9AW72
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SCAMP4
gene id: 9597:SCAMP4
uniprot id: A0A2R9AFK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:C1RL
gene id: 9597:C1RL
uniprot id: A0A2R9BEQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:XPNPEP2
gene id: 9597:XPNPEP2
uniprot id: A0A2R8ZFY1
names: Similarity
messages: Belongs to the peptidase M24B family.

9597:PNCK
gene id: 9597:PNCK
uniprot id: A0A2R9AEK0
uniprot id: A0A2R9AJZ2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:HSD17B10
gene id: 9597:HSD17B10
uniprot id: A0A2R9ANQ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:SLC11A1
gene id: 9597:SLC11A1
uniprot id: A0A2R9B2T1
names: Similarity
messages: Belongs to the NRAMP family.

9597:ACTRT3
gene id: 9597:ACTRT3
uniprot id: A0A2R9BMZ8
names: Similarity
messages: Belongs to the actin family.

9597:GK2
gene id: 9597:GK2
uniprot id: A0A2R8ZLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9597:XAGE2
gene id: 9597:XAGE2
uniprot id: A0A2R8ZDX8
names: Similarity
messages: Belongs to the GAGE family.

9597:KCNMB4
gene id: 9597:KCNMB4
uniprot id: A0A2R9BLF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9597:BVES
gene id: 9597:BVES
uniprot id: A0A2R9BGX9
names: Similarity
messages: Belongs to the popeye family.

9597:MAS1
gene id: 9597:MAS1
uniprot id: A0A2R8Z7J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9597:GDPD2
gene id: 9597:GDPD2
uniprot id: A0A2R8ZGG7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:TM2D2
gene id: 9597:TM2D2
uniprot id: A0A2R9AYD5
names: Subcellular Location Annotation
messages: Membrane

9597:MESD
gene id: 9597:MESD
uniprot id: A0A2R8ZE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9597:SLC27A6
gene id: 9597:SLC27A6
uniprot id: A0A2R9CCJ0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:TMC2
gene id: 9597:TMC2
uniprot id: A0A2R8ZW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:TFF2
gene id: 9597:TFF2
uniprot id: A0A2R9AA66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:STON2
gene id: 9597:STON2
uniprot id: A0A2R9AQ58
uniprot id: A0A2R9AQR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9597:PDYN
gene id: 9597:PDYN
uniprot id: A0A2R9AML7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9597:NAT10
gene id: 9597:NAT10
uniprot id: A0A2R9B8I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9597:MFSD6L
gene id: 9597:MFSD6L
uniprot id: A0A2R8ZHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9597:TNFSF9
gene id: 9597:TNFSF9
uniprot id: A0A2R9CI89
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:INTS11
gene id: 9597:INTS11
uniprot id: A0A2R9BK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

9597:LACC1
gene id: 9597:LACC1
uniprot id: A0A2R9AZJ3
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9597:DERL3
gene id: 9597:DERL3
uniprot id: A0A2R9A1B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9597:NASP
gene id: 9597:NASP
uniprot id: A0A2R9AQM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9597:FAM53C
gene id: 9597:FAM53C
uniprot id: A0A2R9CCJ3
names: Similarity
messages: Belongs to the FAM53 family.

9597:FBN3
gene id: 9597:FBN3
uniprot id: A0A2R9AG92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:KCNB1
gene id: 9597:KCNB1
uniprot id: A0A2R9ADU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9597:NDUFA6
gene id: 9597:NDUFA6
uniprot id: A0A2R9BP15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:LIN28B
gene id: 9597:LIN28B
uniprot id: A0A2R9BPJ2
uniprot id: A0A2R9BPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9597:THG1L
gene id: 9597:THG1L
uniprot id: A0A2R9CC24
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9597:LOC100991696
gene id: 9597:LOC100991696
uniprot id: A0A2R8ZLH9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9597:TH
gene id: 9597:TH
uniprot id: A0A2R9BE28
uniprot id: A0A2R9BMK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9597:GTPBP8
gene id: 9597:GTPBP8
uniprot id: A0A2R9AQX2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9597:CCNG1
gene id: 9597:CCNG1
uniprot id: A0A2R9ABA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9597:EOGT
gene id: 9597:EOGT
uniprot id: A0A2R9BZ03
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9597:SLC14A1
gene id: 9597:SLC14A1
uniprot id: A0A2R8ZJM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9597:SIX4
gene id: 9597:SIX4
uniprot id: A0A2R9AAV0
names: Subcellular Location Annotation
messages: Nucleus

9597:USB1
gene id: 9597:USB1
uniprot id: A0A2R9CAG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9597:NR2E1
gene id: 9597:NR2E1
uniprot id: A0A2R9BUM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:EXOC6B
gene id: 9597:EXOC6B
uniprot id: A0A2R8ZJV0
uniprot id: A0A2R8ZQ79
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9597:MAPK10
gene id: 9597:MAPK10
uniprot id: A0A2R9CES1
uniprot id: A0A2R9CEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9597:FBLN5
gene id: 9597:FBLN5
uniprot id: A0A2R9BAT7
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMCO4
gene id: 9597:TMCO4
uniprot id: A0A2R9AHQ4
names: Similarity
messages: Belongs to the TMCO4 family.

9597:ADAMTS6
gene id: 9597:ADAMTS6
uniprot id: A0A2R9B0X2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:LOC100972898
gene id: 9597:LOC100972898
uniprot id: A0A2R8ZQC9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:CLPTM1L
gene id: 9597:CLPTM1L
uniprot id: A0A2R8ZIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9597:CFB
gene id: 9597:CFB
uniprot id: A0A2R9CIE9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:RSRP1
gene id: 9597:RSRP1
uniprot id: A0A2R9ACL1
names: Similarity
messages: Belongs to the RSRP family.

9597:RAD18
gene id: 9597:RAD18
uniprot id: A0A2R9BAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9597:CIBAR1
gene id: 9597:CIBAR1
uniprot id: A0A2R9CHE5
uniprot id: A0A2R9CPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9597:ELF5
gene id: 9597:ELF5
uniprot id: A0A2R9AK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:MRPS30
gene id: 9597:MRPS30
uniprot id: A0A2R9AC55
names: Subcellular Location Annotation
messages: Mitochondrion

9597:TRIM46
gene id: 9597:TRIM46
uniprot id: A0A2R9A2Q7
uniprot id: A0A2R9A7C6
names: Subcellular Location Annotation
messages: cytoskeleton

9597:MSL3
gene id: 9597:MSL3
uniprot id: A0A2R9BVN3
names: Subcellular Location Annotation
messages: Nucleus

9597:AMDHD1
gene id: 9597:AMDHD1
uniprot id: A0A2R9C3J0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9597:LOC100982890
gene id: 9597:LOC100982890
uniprot id: A0A2R9CDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CIAO1
gene id: 9597:CIAO1
uniprot id: A0A2R9CNN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9597:ILDR1
gene id: 9597:ILDR1
uniprot id: A0A2R9CLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9597:POLR2D
gene id: 9597:POLR2D
uniprot id: A0A2R9CTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9597:CTSV
gene id: 9597:CTSV
uniprot id: A0A2R9C6I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:TMEM107
gene id: 9597:TMEM107
uniprot id: A0A2R9CCI2
names: Subcellular Location Annotation
messages: Membrane

9597:SEC24C
gene id: 9597:SEC24C
uniprot id: A0A2R9C4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:ACSL6
gene id: 9597:ACSL6
uniprot id: A0A2R9C9R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9597:WDR55
gene id: 9597:WDR55
uniprot id: A0A2R9CDN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9597:KYAT3
gene id: 9597:KYAT3
uniprot id: A0A2R9B9H2
names: Subunit
messages: Homodimer.

9597:TNFRSF11B
gene id: 9597:TNFRSF11B
uniprot id: A0A2R9AB16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SFRP2
gene id: 9597:SFRP2
uniprot id: A0A2R9AN78
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:UBA6
gene id: 9597:UBA6
uniprot id: A0A2R9B8U5
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9597:ASB17
gene id: 9597:ASB17
uniprot id: A0A2R9BZ94
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:MSX2
gene id: 9597:MSX2
uniprot id: A1YG93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).
messages: Belongs to the Msh homeobox family.
messages: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
messages: Nucleus

9597:FLVCR1
gene id: 9597:FLVCR1
uniprot id: A0A2R9BHV5
names: Subcellular Location Annotation
messages: Membrane

9597:CD320
gene id: 9597:CD320
uniprot id: A0A2R9AJ50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZNF641
gene id: 9597:ZNF641
uniprot id: A0A2R9CKH3
names: Function
messages: May be involved in transcriptional regulation.

9597:NAA40
gene id: 9597:NAA40
uniprot id: A0A2R9AEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9597:ACTR6
gene id: 9597:ACTR6
uniprot id: A0A2R9B3B3
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9597:SLC35B4
gene id: 9597:SLC35B4
uniprot id: A0A2R9BBZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9597:PPP2R5E
gene id: 9597:PPP2R5E
uniprot id: A0A2R8ZLW4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:SPATA20
gene id: 9597:SPATA20
uniprot id: A0A2R9AID4
uniprot id: A0A2R9AIE2
uniprot id: A0A2R9AIE4
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9597:ZNF408
gene id: 9597:ZNF408
uniprot id: A0A2R9B617
names: Subcellular Location Annotation
messages: Nucleus

9597:KRT82
gene id: 9597:KRT82
uniprot id: A0A2R9AZX5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:NDUFB6
gene id: 9597:NDUFB6
uniprot id: A0A2R9BUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:CRB1
gene id: 9597:CRB1
uniprot id: A0A2R9BCU6
uniprot id: A0A2R9BCW6
uniprot id: A0A2R9BGM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:OVOL3
gene id: 9597:OVOL3
uniprot id: A0A2R9A5T5
uniprot id: A0A2R9AAK0
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM221A
gene id: 9597:FAM221A
uniprot id: A0A2R9C541
uniprot id: A0A2R9C7Y7
uniprot id: A0A2R9CFM5
names: Similarity
messages: Belongs to the FAM221 family.

9597:OPTN
gene id: 9597:OPTN
uniprot id: A0A2R9BNA4
uniprot id: A0A2R9BP57
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9597:TRDMT1
gene id: 9597:TRDMT1
uniprot id: A0A2R9ATZ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9597:MAPRE1
gene id: 9597:MAPRE1
uniprot id: A0A2R8ZQE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9597:YIPF5
gene id: 9597:YIPF5
uniprot id: A0A2R9C7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9597:TLX1
gene id: 9597:TLX1
uniprot id: A0A2R9BZH0
names: Subcellular Location Annotation
messages: Nucleus

9597:SPPL2B
gene id: 9597:SPPL2B
uniprot id: A0A2R9BQN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9597:C22H22orf39
gene id: 9597:C22H22orf39
uniprot id: A0A2R9AJ26
uniprot id: A0A2R9AR96
names: Similarity
messages: Belongs to the UPF0545 family.

9597:SNCG
gene id: 9597:SNCG
uniprot id: A0A2R9AM13
uniprot id: A0A2R9ATH1
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9597:LOC100979269
gene id: 9597:LOC100979269
uniprot id: A0A2R8ZXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9597:ORC4
gene id: 9597:ORC4
uniprot id: A0A2R9CSN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9597:GTDC1
gene id: 9597:GTDC1
uniprot id: A0A2R9AVG0
uniprot id: A0A2R9AZJ0
uniprot id: A0A2R9AZJ7
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9597:NR1H4
gene id: 9597:NR1H4
uniprot id: A0A2R8ZRX0
uniprot id: A0A2R8ZRX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:MS4A1
gene id: 9597:MS4A1
uniprot id: A0A2R9BLG9
names: Similarity
messages: Belongs to the MS4A family.

9597:RNPEP
gene id: 9597:RNPEP
uniprot id: A0A2R9BNE8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:MICOS10
gene id: 9597:MICOS10
uniprot id: A0A2R9CHB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9597:DHH
gene id: 9597:DHH
uniprot id: A0A2R8ZGI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9597:LOC103786072
gene id: 9597:LOC103786072
uniprot id: A0A2R9A3G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9597:LIMK2
gene id: 9597:LIMK2
uniprot id: A0A2R9BXG1
uniprot id: A0A2R9BY65
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9597:ECHDC2
gene id: 9597:ECHDC2
uniprot id: A0A2R9AT31
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:PLCB4
gene id: 9597:PLCB4
uniprot id: A0A2R8ZM50
uniprot id: A0A2R8ZNC8
uniprot id: A0A2R8ZPT1
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9597:CBFA2T3
gene id: 9597:CBFA2T3
uniprot id: A0A2R9ASZ4
uniprot id: A0A2R9AT09
names: Similarity
messages: Belongs to the CBFA2T family.

9597:SHKBP1
gene id: 9597:SHKBP1
uniprot id: A0A2R9CLG4
names: Similarity
messages: Belongs to the KCTD3 family.

9597:CHEK1
gene id: 9597:CHEK1
uniprot id: A0A2R8ZM27
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9597:PLAC1
gene id: 9597:PLAC1
uniprot id: A0A2R8ZPP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9597:GSS
gene id: 9597:GSS
uniprot id: A0A2R9A4W7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9597:DOCK4
gene id: 9597:DOCK4
uniprot id: A0A2R9C4S8
names: Similarity
messages: Belongs to the DOCK family.

9597:GNAT2
gene id: 9597:GNAT2
uniprot id: A0A2R8ZSU7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:EP300
gene id: 9597:EP300
uniprot id: A0A2R9ATU0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:DTYMK
gene id: 9597:DTYMK
uniprot id: A0A2R9C564
names: Similarity
messages: Belongs to the thymidylate kinase family.

9597:OSBPL7
gene id: 9597:OSBPL7
uniprot id: A0A2R8ZWM5
names: Similarity
messages: Belongs to the OSBP family.

9597:NPC1
gene id: 9597:NPC1
uniprot id: A0A2R8ZK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9597:STX12
gene id: 9597:STX12
uniprot id: A0A2R9C5C2
names: Similarity
messages: Belongs to the syntaxin family.

9597:RUNX1T1
gene id: 9597:RUNX1T1
uniprot id: A0A2R9AHS9
uniprot id: A0A2R9AHT1
uniprot id: A0A2R9APW9
uniprot id: A0A2R9APX5
names: Similarity
messages: Belongs to the CBFA2T family.

9597:TSEN15
gene id: 9597:TSEN15
uniprot id: A0A2R9AEB9
uniprot id: A0A2R9AJ54
names: Similarity
messages: Belongs to the SEN15 family.

9597:IRGC
gene id: 9597:IRGC
uniprot id: A0A2R8ZKF0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9597:MBTPS1
gene id: 9597:MBTPS1
uniprot id: A0A2R9CLP8
names: Similarity
messages: Belongs to the peptidase S8 family.

9597:MYOZ2
gene id: 9597:MYOZ2
uniprot id: A0A2R9BB68
names: Similarity
messages: Belongs to the myozenin family.

9597:TPPP3
gene id: 9597:TPPP3
uniprot id: A0A2R9BVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9597:ENO2
gene id: 9597:ENO2
uniprot id: A0A2R9C6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9597:CEPT1
gene id: 9597:CEPT1
uniprot id: A0A2R9CGQ3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9597:CAPN7
gene id: 9597:CAPN7
uniprot id: A0A2R9AQ47
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:FGFBP3
gene id: 9597:FGFBP3
uniprot id: A0A2R9B852
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9597:ARL4C
gene id: 9597:ARL4C
uniprot id: A0A2R8ZD81
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:WNT10B
gene id: 9597:WNT10B
uniprot id: A0A2R9B5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:LOC100987685
gene id: 9597:LOC100987685
uniprot id: A0A2R9B108
names: Subcellular Location Annotation
messages: Membrane

9597:SI
gene id: 9597:SI
uniprot id: A0A2R9A1Y1
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TRIQK
gene id: 9597:TRIQK
uniprot id: A0A2R8ZDC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:FGF6
gene id: 9597:FGF6
uniprot id: A0A2R9C1N8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:RAB33A
gene id: 9597:RAB33A
uniprot id: A0A2R9BLL4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9597:PDSS1
gene id: 9597:PDSS1
uniprot id: A0A2R8ZSC1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9597:PRUNE2
gene id: 9597:PRUNE2
uniprot id: A0A2R9AC58
uniprot id: A0A2R9AI30
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9597:PCYT2
gene id: 9597:PCYT2
uniprot id: A0A2R9AMP0
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9597:LEUTX
gene id: 9597:LEUTX
uniprot id: A0A2R8ZZB6
uniprot id: A0A2R9A0G0
names: Subcellular Location Annotation
messages: Nucleus

9597:LGALS3BP
gene id: 9597:LGALS3BP
uniprot id: A0A2R9AEC1
names: Function
names: Subcellular Location Annotation
messages: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
messages: extracellular matrix

9597:AARS2
gene id: 9597:AARS2
uniprot id: A0A2R8ZCJ3
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9597:ADGRF5
gene id: 9597:ADGRF5
uniprot id: A0A2R9B2W1
uniprot id: A0A2R9B554
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9597:MMP8
gene id: 9597:MMP8
uniprot id: A0A2R9A8Y9
uniprot id: A0A2R9A9L1
names: Similarity
messages: Belongs to the peptidase M10A family.

9597:NOTO
gene id: 9597:NOTO
uniprot id: A0A2R9B8T8
names: Subcellular Location Annotation
messages: Nucleus

9597:MEF2C
gene id: 9597:MEF2C
uniprot id: A0A2R9BUT3
names: Subcellular Location Annotation
messages: Nucleus

9597:CXCL13
gene id: 9597:CXCL13
uniprot id: A0A2R9BK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:TMEM63B
gene id: 9597:TMEM63B
uniprot id: A0A2R8ZS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9597:TAF12
gene id: 9597:TAF12
uniprot id: A0A2R8ZV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9597:LEAP2
gene id: 9597:LEAP2
uniprot id: A0A2R9BJ48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9597:LRRFIP2
gene id: 9597:LRRFIP2
uniprot id: A0A2R9BS38
uniprot id: A0A2R9BSQ3
uniprot id: A0A2R9C160
names: Similarity
messages: Belongs to the LRRFIP family.

9597:TBC1D7
gene id: 9597:TBC1D7
uniprot id: A0A2R9CLM0
uniprot id: A0A2R9CS18
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9597:ADH1B
gene id: 9597:ADH1B
uniprot id: A0A2R9BG66
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:SAMM50
gene id: 9597:SAMM50
uniprot id: A0A2R9A8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9597:LOC100967331
gene id: 9597:LOC100967331
uniprot id: A0A2R9ADB3
uniprot id: A0A2R9AIA7
uniprot id: A0A2R9AIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9597:AGK
gene id: 9597:AGK
uniprot id: A0A2R9CHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9597:ST6GAL1
gene id: 9597:ST6GAL1
uniprot id: A0A2R9AW76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:BDKRB1
gene id: 9597:BDKRB1
uniprot id: A0A2R8Z9J8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9597:KEF42 p07
gene id: 9597:KEF42_p07
uniprot id: E0XI88
uniprot id: Q9T9W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9597:RAD17
gene id: 9597:RAD17
uniprot id: A0A2R9CLE8
uniprot id: A0A2R9CLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9597:IFITM5
gene id: 9597:IFITM5
uniprot id: A0A2R9B389
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:SLITRK3
gene id: 9597:SLITRK3
uniprot id: A0A2R8ZS61
names: Similarity
messages: Belongs to the SLITRK family.

9597:PIWIL3
gene id: 9597:PIWIL3
uniprot id: A0A2R9AQ60
names: Similarity
messages: Belongs to the argonaute family.

9597:POU5F1
gene id: 9597:POU5F1
uniprot id: A0A2R9BMQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9597:NHP2
gene id: 9597:NHP2
uniprot id: A0A2R9A0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9597:PIGO
gene id: 9597:PIGO
uniprot id: A0A2R8ZMP4
uniprot id: A0A2R8ZNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:BGN
gene id: 9597:BGN
uniprot id: A0A2R9AYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9597:FAM163A
gene id: 9597:FAM163A
uniprot id: A0A2R9B445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9597:CD74
gene id: 9597:CD74
uniprot id: A0A2R9BGX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100986973
gene id: 9597:LOC100986973
uniprot id: A0A2R8ZQM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:NADK
gene id: 9597:NADK
uniprot id: A0A2R9AMP6
names: Similarity
messages: Belongs to the NAD kinase family.

9597:PABPC4
gene id: 9597:PABPC4
uniprot id: A0A2R9CJF4
uniprot id: A0A2R9CS92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9597:SLC24A1
gene id: 9597:SLC24A1
uniprot id: A0A2R9CF50
uniprot id: A0A2R9CF90
uniprot id: A0A2R9CFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9597:CLDN17
gene id: 9597:CLDN17
uniprot id: A0A2R9AVC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:CXHXorf56
gene id: 9597:CXHXorf56
uniprot id: A0A2R8ZWA0
names: Similarity
messages: Belongs to the STEEP1 family.

9597:NOB1
gene id: 9597:NOB1
uniprot id: A0A2R9C8W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9597:LOC100968942
gene id: 9597:LOC100968942
uniprot id: A0A2R8ZMZ9
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9597:ALG9
gene id: 9597:ALG9
uniprot id: A0A2R9BWM6
uniprot id: A0A2R9C697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:IGFBP6
gene id: 9597:IGFBP6
uniprot id: A0A2R9AYI0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:VPS25
gene id: 9597:VPS25
uniprot id: A0A2R9B279
names: Similarity
messages: Belongs to the VPS25 family.

9597:KRT74
gene id: 9597:KRT74
uniprot id: A0A2R9AVZ5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:FADS2
gene id: 9597:FADS2
uniprot id: A0A2R9BKZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9597:TUB
gene id: 9597:TUB
uniprot id: A0A2R9APF1
uniprot id: A0A2R9AW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9597:GPR108
gene id: 9597:GPR108
uniprot id: A0A2R9AAP6
names: Subcellular Location Annotation
messages: Membrane

9597:IMP4
gene id: 9597:IMP4
uniprot id: A0A2R9A6L9
names: Subcellular Location Annotation
messages: nucleolus

9597:DNAJA1
gene id: 9597:DNAJA1
uniprot id: A0A2R8ZXS2
names: Subcellular Location Annotation
messages: Membrane

9597:LDLRAD4
gene id: 9597:LDLRAD4
uniprot id: A0A2R8Z883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9597:SPDYE4
gene id: 9597:SPDYE4
uniprot id: A0A2R9CIC7
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9597:CNOT3
gene id: 9597:CNOT3
uniprot id: A0A2R8Z7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9597:IDS
gene id: 9597:IDS
uniprot id: A0A2R9BWW8
uniprot id: A0A2R9C0B2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:SMAD9
gene id: 9597:SMAD9
uniprot id: A0A2R9A3J1
uniprot id: A0A2R9A4Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:RCL1
gene id: 9597:RCL1
uniprot id: A0A2R9BKG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9597:AFF1
gene id: 9597:AFF1
uniprot id: A0A2R9A544
names: Similarity
messages: Belongs to the AF4 family.

9597:PDE2A
gene id: 9597:PDE2A
uniprot id: A0A2R9BH84
uniprot id: A0A2R9BH94
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:TK1
gene id: 9597:TK1
uniprot id: A0A2R9ADQ5
names: Similarity
messages: Belongs to the thymidine kinase family.

9597:KRBOX4
gene id: 9597:KRBOX4
uniprot id: A0A2R9ABC9
names: Function
messages: May be involved in transcriptional regulation.

9597:PNMA2
gene id: 9597:PNMA2
uniprot id: A0A2R9AVS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9597:HPDL
gene id: 9597:HPDL
uniprot id: A0A2R8ZR72
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9597:CLDN23
gene id: 9597:CLDN23
uniprot id: A0A2R9AP40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:RNF7
gene id: 9597:RNF7
uniprot id: A0A2R9BAE1
names: Similarity
messages: Belongs to the RING-box family.

9597:TTC39A
gene id: 9597:TTC39A
uniprot id: A0A2R9AH31
uniprot id: A0A2R9ALT7
names: Similarity
messages: Belongs to the TTC39 family.

9597:CLCA4
gene id: 9597:CLCA4
uniprot id: A0A2R9AF53
names: Similarity
messages: Belongs to the CLCR family.

9597:FADS3
gene id: 9597:FADS3
uniprot id: A0A2R8ZW45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9597:MOK
gene id: 9597:MOK
uniprot id: A0A2R9A571
uniprot id: A0A2R9A576
uniprot id: A0A2R9A9X7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MRPL20
gene id: 9597:MRPL20
uniprot id: A0A2R9CBH5
uniprot id: A0A2R9CBN9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9597:RIBC1
gene id: 9597:RIBC1
uniprot id: A0A2R9CGR9
uniprot id: A0A2R9CJG0
names: Similarity
messages: Belongs to the RIB43A family.

9597:MRAP
gene id: 9597:MRAP
uniprot id: A0A2R8Z7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TMEM17
gene id: 9597:TMEM17
uniprot id: A0A2R8ZC99
names: Subcellular Location Annotation
messages: Membrane

9597:HOXB4
gene id: 9597:HOXB4
uniprot id: A0A2R9C1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:NCK1
gene id: 9597:NCK1
uniprot id: A0A2R9A1S6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9597:TMEM106A
gene id: 9597:TMEM106A
uniprot id: A0A2R9B6A7
uniprot id: A0A2R9B6B3
uniprot id: A0A2R9B7T8
names: Similarity
messages: Belongs to the TMEM106 family.

9597:FAM163B
gene id: 9597:FAM163B
uniprot id: A0A2R9BG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9597:UVSSA
gene id: 9597:UVSSA
uniprot id: A0A2R9C1F3
names: Similarity
messages: Belongs to the UVSSA family.

9597:ELOVL6
gene id: 9597:ELOVL6
uniprot id: A0A2R9AUT1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9597:VPS26A
gene id: 9597:VPS26A
uniprot id: A0A2R9C7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9597:COMTD1
gene id: 9597:COMTD1
uniprot id: A0A2R9A5Z9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9597:ERCC4
gene id: 9597:ERCC4
uniprot id: A0A2R9BAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9597:STC1
gene id: 9597:STC1
uniprot id: A0A2R9A5G4
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9597:ALOX5AP
gene id: 9597:ALOX5AP
uniprot id: A0A2R9AV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:HNRNPK
gene id: 9597:HNRNPK
uniprot id: A0A2R9CSP4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9597:CDK5
gene id: 9597:CDK5
uniprot id: A0A2R9B886
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MMAB
gene id: 9597:MMAB
uniprot id: A0A2R9ANE0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9597:ERLIN2
gene id: 9597:ERLIN2
uniprot id: A0A2R9B4K8
uniprot id: A0A2R9B717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9597:KIF14
gene id: 9597:KIF14
uniprot id: A0A2R8Z602
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:NARF
gene id: 9597:NARF
uniprot id: A0A2R9BB87
names: Similarity
messages: Belongs to the NARF family.

9597:CYP1A2
gene id: 9597:CYP1A2
uniprot id: A0A2R8ZXU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:GPR156
gene id: 9597:GPR156
uniprot id: A0A2R8ZUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:VPS35
gene id: 9597:VPS35
uniprot id: A0A2R8ZKL0
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9597:SEMA3A
gene id: 9597:SEMA3A
uniprot id: A0A2R9BBJ2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:EEF1AKMT1
gene id: 9597:EEF1AKMT1
uniprot id: A0A2R9C8B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9597:LOC100986336
gene id: 9597:LOC100986336
uniprot id: A0A2R9AR52
uniprot id: B3Y663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Lysosome
messages: Membrane
messages: cytoskeleton
messages: phagosome

9597:GNS
gene id: 9597:GNS
uniprot id: A0A2R9AU63
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:SESN3
gene id: 9597:SESN3
uniprot id: A0A2R8ZUF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9597:TSNAX
gene id: 9597:TSNAX
uniprot id: A0A2R9ABA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9597:KMT5B
gene id: 9597:KMT5B
uniprot id: A0A2R9BT57
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9597:TOM1
gene id: 9597:TOM1
uniprot id: A0A2R9BZ40
names: Similarity
messages: Belongs to the TOM1 family.

9597:LOC100972703
gene id: 9597:LOC100972703
uniprot id: A0A2R9C5Z0
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9597:EVL
gene id: 9597:EVL
uniprot id: A0A2R9AR90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9597:ELOVL7
gene id: 9597:ELOVL7
uniprot id: A0A2R9CE84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:TLCD4
gene id: 9597:TLCD4
uniprot id: A0A2R9C637
names: Subcellular Location Annotation
messages: Membrane

9597:LAMP5
gene id: 9597:LAMP5
uniprot id: A0A2R8ZH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9597:SLCO5A1
gene id: 9597:SLCO5A1
uniprot id: A0A2R8ZIK4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TNFRSF21
gene id: 9597:TNFRSF21
uniprot id: A0A2R9ADT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GNRH1
gene id: 9597:GNRH1
uniprot id: A0A2R8ZXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9597:SSTR1
gene id: 9597:SSTR1
uniprot id: A0A2R8ZDJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:CDK10
gene id: 9597:CDK10
uniprot id: A0A2R9A3I8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TARBP2
gene id: 9597:TARBP2
uniprot id: A0A2R9ABA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9597:AMELX
gene id: 9597:AMELX
uniprot id: A0A2R9A2H0
names: Similarity
messages: Belongs to the amelogenin family.

9597:FAM189A2
gene id: 9597:FAM189A2
uniprot id: A0A2R8ZDF9
names: Similarity
messages: Belongs to the ENTREP family.

9597:AQR
gene id: 9597:AQR
uniprot id: A0A2R9AK31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

9597:NKX2-5
gene id: 9597:NKX2-5
uniprot id: A0A2R9AEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9597:PPP2R2A
gene id: 9597:PPP2R2A
uniprot id: A0A2R9B314
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:FAM124B
gene id: 9597:FAM124B
uniprot id: A0A2R8Z6X8
names: Similarity
messages: Belongs to the FAM124 family.

9597:EIF6
gene id: 9597:EIF6
uniprot id: A0A2R9ADA3
uniprot id: A0A2R9AIA4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-155 and Ser-156 promotes nuclear export.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9597:ARR3
gene id: 9597:ARR3
uniprot id: A0A2R9A5X7
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

9597:UBE2D2
gene id: 9597:UBE2D2
uniprot id: A0A2R9CDE7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:PEX5
gene id: 9597:PEX5
uniprot id: A0A2R9C1R3
uniprot id: A0A2R9C299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9597:PPM1B
gene id: 9597:PPM1B
uniprot id: A0A2R9CJN8
uniprot id: A0A2R9CJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9597:CALU
gene id: 9597:CALU
uniprot id: A0A2R8ZZY3
uniprot id: A0A2R9A482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9597:MIS12
gene id: 9597:MIS12
uniprot id: A0A2R8Z9A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9597:CSNK1G1
gene id: 9597:CSNK1G1
uniprot id: A0A2R9BBQ7
uniprot id: A0A2R9BBS5
uniprot id: A0A2R9BFG2
uniprot id: A0A2R9BFH2
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9597:CYP2J2
gene id: 9597:CYP2J2
uniprot id: A0A2R9C539
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:LOC103782837
gene id: 9597:LOC103782837
uniprot id: A0A2R9CC67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9597:BCO1
gene id: 9597:BCO1
uniprot id: A0A2R8ZE23
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9597:GLO1
gene id: 9597:GLO1
uniprot id: A0A2R9BBA5
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9597:CD36
gene id: 9597:CD36
uniprot id: A0A2R8Z8C9
uniprot id: A0A2R8Z8H3
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9597:ZFP69B
gene id: 9597:ZFP69B
uniprot id: A0A2R9C2T6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:TAFA3
gene id: 9597:TAFA3
uniprot id: A0A2R8ZUI9
names: Similarity
messages: Belongs to the TAFA family.

9597:RPS4X
gene id: 9597:RPS4X
uniprot id: A0A2R9C5L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9597:NUCB2
gene id: 9597:NUCB2
uniprot id: A0A2R9C7N7
names: Similarity
messages: Belongs to the nucleobindin family.

9597:SYNGR4
gene id: 9597:SYNGR4
uniprot id: A0A2R9CHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9597:OASL
gene id: 9597:OASL
uniprot id: A0A2R9B9Z2
uniprot id: A0A2R9BFY8
names: Similarity
messages: Belongs to the 2-5A synthase family.

9597:GPN1
gene id: 9597:GPN1
uniprot id: A0A2R8ZRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9597:DEFB132
gene id: 9597:DEFB132
uniprot id: A0A2R9C956
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:MCHR1
gene id: 9597:MCHR1
uniprot id: A0A2R9AFP0
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9597:CNOT6
gene id: 9597:CNOT6
uniprot id: A0A2R9AR59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9597:TNMD
gene id: 9597:TNMD
uniprot id: A0A2R9B8B7
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9597:NCOA2
gene id: 9597:NCOA2
uniprot id: A0A2R9AI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9597:STAG2
gene id: 9597:STAG2
uniprot id: A0A2R9BTK7
uniprot id: A0A2R9BU86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9597:PMVK
gene id: 9597:PMVK
uniprot id: A0A2R9C6W1
names: Subcellular Location Annotation
messages: cytosol

9597:SMIM22
gene id: 9597:SMIM22
uniprot id: A0A2R8ZPC4
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100973279
gene id: 9597:LOC100973279
uniprot id: A0A2R9CF96
names: Similarity
messages: Belongs to the MIX23 family.

9597:KRT19
gene id: 9597:KRT19
uniprot id: A0A2R9ALU5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:TM9SF1
gene id: 9597:TM9SF1
uniprot id: A0A2R9CC98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9597:ST3GAL1
gene id: 9597:ST3GAL1
uniprot id: A0A2R9C5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:B3GNT5
gene id: 9597:B3GNT5
uniprot id: A0A2R8Z615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:SLC12A1
gene id: 9597:SLC12A1
uniprot id: A0A2R8Z779
uniprot id: A0A2R8Z783
uniprot id: A0A2R8ZB10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9597:CEBPZ
gene id: 9597:CEBPZ
uniprot id: A0A2R9CR99
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9597:DEFA4
gene id: 9597:DEFA4
uniprot id: A0A2R8Z9J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9597:GABRR3
gene id: 9597:GABRR3
uniprot id: A0A2R9BJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:WDR4
gene id: 9597:WDR4
uniprot id: A0A2R9BLN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9597:NDRG2
gene id: 9597:NDRG2
uniprot id: A0A2R9BQT1
uniprot id: A0A2R9BUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

9597:RPS15A
gene id: 9597:RPS15A
uniprot id: A0A2R9ALI7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9597:LGR5
gene id: 9597:LGR5
uniprot id: A0A2R9AWL1
uniprot id: A0A2R9B2G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:RDH10
gene id: 9597:RDH10
uniprot id: A0A2R9C8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:FNIP2
gene id: 9597:FNIP2
uniprot id: A0A2R9ACN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9597:CD37
gene id: 9597:CD37
uniprot id: A0A2R9BM06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:DAG1
gene id: 9597:DAG1
uniprot id: A0A2R9BAV6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9597:CA14
gene id: 9597:CA14
uniprot id: A0A2R9A052
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9597:BET1
gene id: 9597:BET1
uniprot id: A0A2R9CDV3
names: Subcellular Location Annotation
messages: Membrane

9597:IL6R
gene id: 9597:IL6R
uniprot id: A0A2R9A372
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9597:PSMA6
gene id: 9597:PSMA6
uniprot id: A0A2R8ZU34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:SLC43A1
gene id: 9597:SLC43A1
uniprot id: A0A2R8ZFD1
names: Subcellular Location Annotation
messages: Membrane

9597:NUBP1
gene id: 9597:NUBP1
uniprot id: A0A2R9A296
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9597:TOP3A
gene id: 9597:TOP3A
uniprot id: A0A2R8ZPA3
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9597:RPS27L
gene id: 9597:RPS27L
uniprot id: A0A2R8ZTE7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:SEMA6D
gene id: 9597:SEMA6D
uniprot id: A0A2R9AC21
uniprot id: A0A2R9AC34
uniprot id: A0A2R9AH08
uniprot id: A0A2R9AI10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RPAP2
gene id: 9597:RPAP2
uniprot id: A0A2R9BAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9597:GADL1
gene id: 9597:GADL1
uniprot id: A0A2R8ZX33
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:CHRNA6
gene id: 9597:CHRNA6
uniprot id: A0A2R9BF04
uniprot id: A0A2R9BIW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:PIP4P1
gene id: 9597:PIP4P1
uniprot id: A0A2R9A1B6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9597:B2M
gene id: 9597:B2M
uniprot id: A0A2R8ZGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9597:STON1
gene id: 9597:STON1
uniprot id: A0A2R8ZTT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9597:CA5A
gene id: 9597:CA5A
uniprot id: A0A2R9AD52
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9597:TMED5
gene id: 9597:TMED5
uniprot id: A0A2R8ZVQ1
uniprot id: A0A2R8ZXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9597:OXER1
gene id: 9597:OXER1
uniprot id: A0A2R8ZIX0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:PEX16
gene id: 9597:PEX16
uniprot id: A0A2R9CBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9597:RNPEPL1
gene id: 9597:RNPEPL1
uniprot id: A0A2R9B711
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:GPN3
gene id: 9597:GPN3
uniprot id: A0A2R9AHM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9597:AGPAT2
gene id: 9597:AGPAT2
uniprot id: A0A2R9BV35
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9597:C1QBP
gene id: 9597:C1QBP
uniprot id: A0A2R9AAP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9597:TSPAN5
gene id: 9597:TSPAN5
uniprot id: A0A2R9CKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:LAMTOR3
gene id: 9597:LAMTOR3
uniprot id: A0A2R9B362
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9597:APPL1
gene id: 9597:APPL1
uniprot id: A0A2R9BK75
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9597:LOC100979289
gene id: 9597:LOC100979289
uniprot id: A0A2R8ZGW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:TCEANC2
gene id: 9597:TCEANC2
uniprot id: A0A2R9C9F9
names: Subcellular Location Annotation
messages: Nucleus

9597:HDAC2
gene id: 9597:HDAC2
uniprot id: A0A2R9AS16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9597:ASIC1
gene id: 9597:ASIC1
uniprot id: A0A2R9BGA3
uniprot id: A0A2R9BH83
names: Subcellular Location Annotation
messages: Membrane

9597:ITGB7
gene id: 9597:ITGB7
uniprot id: A0A2R9BLF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9597:PRR15L
gene id: 9597:PRR15L
uniprot id: A0A2R8Z7H9
names: Similarity
messages: Belongs to the PRR15 family.

9597:PFN4
gene id: 9597:PFN4
uniprot id: A0A2R9BZB6
names: Similarity
messages: Belongs to the profilin family.

9597:LBP
gene id: 9597:LBP
uniprot id: A0A2R9B8P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9597:SLC1A3
gene id: 9597:SLC1A3
uniprot id: A0A2R9AQ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:GARS1
gene id: 9597:GARS1
uniprot id: A0A2R9BJK5
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9597:ASB4
gene id: 9597:ASB4
uniprot id: A0A2R9CA43
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:LOC106634229
gene id: 9597:LOC106634229
uniprot id: A0A2R9AZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9597:SLX4
gene id: 9597:SLX4
uniprot id: A0A2R9CIP7
names: Similarity
messages: Belongs to the SLX4 family.

9597:CTNS
gene id: 9597:CTNS
uniprot id: A0A2R9BGF6
uniprot id: A0A2R9BNZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9597:PLA2G3
gene id: 9597:PLA2G3
uniprot id: A0A2R9A6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9597:GNA13
gene id: 9597:GNA13
uniprot id: A0A2R8ZGE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9597:LMOD3
gene id: 9597:LMOD3
uniprot id: A0A2R9AZ59
names: Subcellular Location Annotation
messages: cytoskeleton

9597:NFKB1
gene id: 9597:NFKB1
uniprot id: A0A2R9AKQ2
uniprot id: A0A2R9AST7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:LOC100975235
gene id: 9597:LOC100975235
uniprot id: A0A2R8ZAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FAM20B
gene id: 9597:FAM20B
uniprot id: A0A2R9C474
names: Similarity
messages: Belongs to the FAM20 family.

9597:LOC100982531
gene id: 9597:LOC100982531
uniprot id: A0A2R9A4U4
names: Subcellular Location Annotation
messages: Membrane

9597:REEP2
gene id: 9597:REEP2
uniprot id: A0A2R9AKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9597:PSMB8
gene id: 9597:PSMB8
uniprot id: A0A2R9CBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:S100B
gene id: 9597:S100B
uniprot id: A0A2R9ADJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9597:DOLPP1
gene id: 9597:DOLPP1
uniprot id: A0A2R9BRC9
uniprot id: A0A2R9BUU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9597:VPS11
gene id: 9597:VPS11
uniprot id: A0A2R8ZI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9597:FSCN2
gene id: 9597:FSCN2
uniprot id: A0A2R9CIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9597:GABRQ
gene id: 9597:GABRQ
uniprot id: A0A2R9ALH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:SEMA3D
gene id: 9597:SEMA3D
uniprot id: A0A2R9BIA1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GRB10
gene id: 9597:GRB10
uniprot id: A0A2R8ZJ58
uniprot id: A0A2R8ZPN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9597:GREB1L
gene id: 9597:GREB1L
uniprot id: A0A2R8ZHH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

9597:B3GALT1
gene id: 9597:B3GALT1
uniprot id: Q7JK25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.
messages: Golgi apparatus membrane

9597:MSH4
gene id: 9597:MSH4
uniprot id: A0A2R9BEZ3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9597:LOC100970104
gene id: 9597:LOC100970104
uniprot id: A0A2R8ZB08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100983218
gene id: 9597:LOC100983218
uniprot id: A0A2R8ZCH5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:CHRDL1
gene id: 9597:CHRDL1
uniprot id: A0A2R9ASZ3
names: Subcellular Location Annotation
messages: Secreted

9597:TRAPPC4
gene id: 9597:TRAPPC4
uniprot id: A0A2R9BV14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9597:GAL
gene id: 9597:GAL
uniprot id: A0A2R9ADP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9597:KRTCAP2
gene id: 9597:KRTCAP2
uniprot id: A0A2R9A4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9597:CDC37L1
gene id: 9597:CDC37L1
uniprot id: A0A2R9BNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9597:FOXJ2
gene id: 9597:FOXJ2
uniprot id: A0A2R9C3N6
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100975309
gene id: 9597:LOC100975309
uniprot id: A0A2R9CHA8
names: Similarity
messages: Belongs to the intermediate filament family.

9597:TPD52
gene id: 9597:TPD52
uniprot id: A0A2R9BQP3
names: Similarity
messages: Belongs to the TPD52 family.

9597:KCNV2
gene id: 9597:KCNV2
uniprot id: A0A2R9CCF3
names: Subcellular Location Annotation
messages: Membrane

9597:C4BPB
gene id: 9597:C4BPB
uniprot id: A0A2R9AXB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TRPC4
gene id: 9597:TRPC4
uniprot id: A0A2R8ZRZ3
uniprot id: A0A2R8ZXU6
names: Subcellular Location Annotation
messages: Membrane

9597:AKAP13
gene id: 9597:AKAP13
uniprot id: A0A2R9BXA9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:WSCD1
gene id: 9597:WSCD1
uniprot id: A0A2R9CDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9597:NFIL3
gene id: 9597:NFIL3
uniprot id: A0A2R8Z9C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9597:CCK
gene id: 9597:CCK
uniprot id: A0A2R8ZA42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9597:BTNL3
gene id: 9597:BTNL3
uniprot id: A0A2R9AMI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9597:KPNA7
gene id: 9597:KPNA7
uniprot id: A0A2R9C214
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9597:CWC15
gene id: 9597:CWC15
uniprot id: A0A2R9AU78
names: Similarity
messages: Belongs to the CWC15 family.

9597:LIM2
gene id: 9597:LIM2
uniprot id: A0A2R9C2B7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9597:MGST1
gene id: 9597:MGST1
uniprot id: A0A2R9AZ36
uniprot id: A0A2R9AZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9597:COG1
gene id: 9597:COG1
uniprot id: A0A2R8ZKL3
names: Similarity
messages: Belongs to the COG1 family.

9597:CPA4
gene id: 9597:CPA4
uniprot id: A0A2R8ZQY8
uniprot id: A0A2R8ZTX9
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:NLRP4
gene id: 9597:NLRP4
uniprot id: A0A2R9AX44
names: Similarity
messages: Belongs to the NLRP family.

9597:TMEM256
gene id: 9597:TMEM256
uniprot id: A0A2R9BY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9597:BARX2
gene id: 9597:BARX2
uniprot id: A0A2R9A129
names: Subcellular Location Annotation
messages: Nucleus

9597:HOXB6
gene id: 9597:HOXB6
uniprot id: A0A2R9ALG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:SLC20A1
gene id: 9597:SLC20A1
uniprot id: A0A2R9A132
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9597:C19H19orf54
gene id: 9597:C19H19orf54
uniprot id: A0A2R9AIA6
names: Similarity
messages: Belongs to the UPF0692 family.

9597:MTURN
gene id: 9597:MTURN
uniprot id: A0A2R9BXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9597:EPN2
gene id: 9597:EPN2
uniprot id: A0A2R9AAA2
uniprot id: A0A2R9AAB0
names: Similarity
messages: Belongs to the epsin family.

9597:PIK3CB
gene id: 9597:PIK3CB
uniprot id: A0A2R9AJY1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:BMP4
gene id: 9597:BMP4
uniprot id: A0A2R9A169
names: Similarity
messages: Belongs to the TGF-beta family.

9597:LOC100972441
gene id: 9597:LOC100972441
uniprot id: A0A2R9AS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ARSJ
gene id: 9597:ARSJ
uniprot id: A0A2R9CAG4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:UBE2E1
gene id: 9597:UBE2E1
uniprot id: A0A2R9C2G2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:ITGB3BP
gene id: 9597:ITGB3BP
uniprot id: A0A2R9AU50
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9597:POGLUT2
gene id: 9597:POGLUT2
uniprot id: A0A2R9A598
names: Similarity
messages: Belongs to the KDELC family.

9597:TLR3
gene id: 9597:TLR3
uniprot id: B3Y621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:SETD3
gene id: 9597:SETD3
uniprot id: A0A2R9BBP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9597:PRPF31
gene id: 9597:PRPF31
uniprot id: A0A2R9ALM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9597:GPM6B
gene id: 9597:GPM6B
uniprot id: A0A2R9BQI3
uniprot id: A0A2R9BQI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9597:PSMG1
gene id: 9597:PSMG1
uniprot id: A0A2R9A631
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9597:NTHL1
gene id: 9597:NTHL1
uniprot id: A0A2R8Z7L4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9597:YPEL1
gene id: 9597:YPEL1
uniprot id: A0A2R9AQX1
names: Similarity
messages: Belongs to the yippee family.

9597:GLYAT
gene id: 9597:GLYAT
uniprot id: A0A2R9BLT6
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9597:LOC100973313
gene id: 9597:LOC100973313
uniprot id: A0A2R8ZP55
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:AADACL4
gene id: 9597:AADACL4
uniprot id: A0A2R9CKS5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9597:RPL3
gene id: 9597:RPL3
uniprot id: A0A2R9BQK0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9597:ISM2
gene id: 9597:ISM2
uniprot id: A0A2R9AX37
names: Similarity
messages: Belongs to the isthmin family.

9597:LOC100980406
gene id: 9597:LOC100980406
uniprot id: A0A2R8Z9V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TMEM115
gene id: 9597:TMEM115
uniprot id: A0A2R8ZJV2
names: Subcellular Location Annotation
messages: Membrane

9597:ELK3
gene id: 9597:ELK3
uniprot id: A0A2R9CGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:BBOX1
gene id: 9597:BBOX1
uniprot id: A0A2R9B329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9597:DCBLD2
gene id: 9597:DCBLD2
uniprot id: A0A2R9ABR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MPC1
gene id: 9597:MPC1
uniprot id: A0A2R9B2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:HMOX2
gene id: 9597:HMOX2
uniprot id: A0A2R8ZZ65
names: Similarity
messages: Belongs to the heme oxygenase family.

9597:KEF42 p01
gene id: 9597:KEF42_p01
uniprot id: Q9T9W4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9597:TUBG1
gene id: 9597:TUBG1
uniprot id: A0A2R9A2E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9597:NMT1
gene id: 9597:NMT1
uniprot id: A0A2R9BQM1
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9597:SRSF5
gene id: 9597:SRSF5
uniprot id: A0A2R9A8C0
names: Similarity
messages: Belongs to the splicing factor SR family.

9597:TIMM17A
gene id: 9597:TIMM17A
uniprot id: A0A2R8ZTT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9597:SLC7A4
gene id: 9597:SLC7A4
uniprot id: A0A2R9A9F8
names: Subcellular Location Annotation
messages: Membrane

9597:CSNK2A1
gene id: 9597:CSNK2A1
uniprot id: A0A2R9AMW1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:LOC100990769
gene id: 9597:LOC100990769
uniprot id: A0A2R8ZAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:NIFK
gene id: 9597:NIFK
uniprot id: A0A2R9B3P2
names: Subcellular Location Annotation
messages: nucleolus

9597:LOC100968761
gene id: 9597:LOC100968761
uniprot id: A0A2R9AVM7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9597:LOC100981207
gene id: 9597:LOC100981207
uniprot id: A0A2R8ZGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ALDH1L1
gene id: 9597:ALDH1L1
uniprot id: A0A2R9AW45
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9597:LOC100993774
gene id: 9597:LOC100993774
uniprot id: A0A2R9A7T2
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

9597:BAX
gene id: 9597:BAX
uniprot id: A0A2R9BX16
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:YPEL5
gene id: 9597:YPEL5
uniprot id: A0A2R9A6P4
names: Similarity
messages: Belongs to the yippee family.

9597:TM6SF2
gene id: 9597:TM6SF2
uniprot id: A0A2R9CIK7
names: Subcellular Location Annotation
messages: Membrane

9597:NIPAL1
gene id: 9597:NIPAL1
uniprot id: A0A2R9AIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9597:EDEM3
gene id: 9597:EDEM3
uniprot id: A0A2R9BPZ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9597:CRYL1
gene id: 9597:CRYL1
uniprot id: A0A2R9CGF8
uniprot id: A0A2R9CJ69
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9597:DENND5B
gene id: 9597:DENND5B
uniprot id: A0A2R8Z705
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CNOT8
gene id: 9597:CNOT8
uniprot id: A0A2R9CJP8
uniprot id: A0A2R9CJP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9597:GIP
gene id: 9597:GIP
uniprot id: A0A2R9A756
names: Subcellular Location Annotation
messages: Secreted

9597:SERPINB1
gene id: 9597:SERPINB1
uniprot id: A0A2R9CF34
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9597:VPS52
gene id: 9597:VPS52
uniprot id: A0A2R9BVC3
names: Similarity
messages: Belongs to the VPS52 family.

9597:GRIN2A
gene id: 9597:GRIN2A
uniprot id: A0A2R9AYV3
uniprot id: A0A2R9AYX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9597:MSN
gene id: 9597:MSN
uniprot id: A0A2R9AZU4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:ZFP57
gene id: 9597:ZFP57
uniprot id: A0A2R8ZRJ3
names: Function
messages: May be involved in transcriptional regulation.

9597:MYO1G
gene id: 9597:MYO1G
uniprot id: A0A2R9C381
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:SFRP4
gene id: 9597:SFRP4
uniprot id: A0A2R9AVJ4
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100972109
gene id: 9597:LOC100972109
uniprot id: A0A2R9AQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:EHF
gene id: 9597:EHF
uniprot id: A0A2R9B7J1
uniprot id: A1YG61
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: The PNT domain acts as a transcriptional activator.
messages: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).

9597:GATC
gene id: 9597:GATC
uniprot id: A0A2R9A3N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9597:ZNF77
gene id: 9597:ZNF77
uniprot id: A0A2R9AGP0
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC103784643
gene id: 9597:LOC103784643
uniprot id: A0A2R9BRC2
names: Function
messages: May be involved in transcriptional regulation.

9597:EPS8
gene id: 9597:EPS8
uniprot id: A0A2R9BSG7
names: Similarity
messages: Belongs to the EPS8 family.

9597:MYMK
gene id: 9597:MYMK
uniprot id: A0A2R9AL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9597:CLEC12A
gene id: 9597:CLEC12A
uniprot id: A0A2R8ZC44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MAP2K1
gene id: 9597:MAP2K1
uniprot id: A0A2R9A4U3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:LOC100973583
gene id: 9597:LOC100973583
uniprot id: A0A2R9BJY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9597:TUBG2
gene id: 9597:TUBG2
uniprot id: A0A2R9BLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9597:ACTL6B
gene id: 9597:ACTL6B
uniprot id: A0A2R9B2N6
names: Similarity
messages: Belongs to the actin family.

9597:LOC100979847
gene id: 9597:LOC100979847
uniprot id: A0A2R8ZL84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Odorant receptor.

9597:TRNT1
gene id: 9597:TRNT1
uniprot id: A0A2R9CS35
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9597:LOC100993256
gene id: 9597:LOC100993256
uniprot id: A0A2R9A8A8
uniprot id: A0A2R9CKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9597:ZNF333
gene id: 9597:ZNF333
uniprot id: A0A2R9A239
names: Function
messages: May be involved in transcriptional regulation.

9597:RIPK2
gene id: 9597:RIPK2
uniprot id: A0A2R9CNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9597:AQP6
gene id: 9597:AQP6
uniprot id: A0A2R9CJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:RARB
gene id: 9597:RARB
uniprot id: A0A2R9BQB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:TNFRSF10D
gene id: 9597:TNFRSF10D
uniprot id: A0A2R9B2D6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZIM3
gene id: 9597:ZIM3
uniprot id: A0A2R9B3Q0
names: Function
messages: May be involved in transcriptional regulation.

9597:NDRG3
gene id: 9597:NDRG3
uniprot id: A0A2R9A671
uniprot id: A0A2R9AAY5
uniprot id: A0A2R9ABI4
names: Similarity
messages: Belongs to the NDRG family.

9597:SYCP2L
gene id: 9597:SYCP2L
uniprot id: A0A2R9A5P2
uniprot id: A0A2R9A6V5
uniprot id: A0A2R9AAZ4
uniprot id: A0A2R9AB04
names: Similarity
messages: Belongs to the TMEM14 family.

9597:ADCK2
gene id: 9597:ADCK2
uniprot id: A0A2R9AZ50
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:LOC100972759
gene id: 9597:LOC100972759
uniprot id: A0A2R8ZD62
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9597:TFIP11
gene id: 9597:TFIP11
uniprot id: A0A2R9BQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9597:LOC100977675
gene id: 9597:LOC100977675
uniprot id: A0A2R8ZJR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TWSG1
gene id: 9597:TWSG1
uniprot id: A0A2R9A035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9597:MED12
gene id: 9597:MED12
uniprot id: A0A2R9APR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9597:HTR3B
gene id: 9597:HTR3B
uniprot id: A0A2R8ZWJ3
names: Subcellular Location Annotation
messages: Membrane

9597:CASP10
gene id: 9597:CASP10
uniprot id: A0A2R9CBN6
uniprot id: A0A2R9CBT5
uniprot id: A0A2R9CBU0
uniprot id: A0A2R9CEB3
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:KRT6C
gene id: 9597:KRT6C
uniprot id: A0A2R8ZE58
names: Similarity
messages: Belongs to the intermediate filament family.

9597:MED6
gene id: 9597:MED6
uniprot id: A0A2R9CA51
uniprot id: A0A2R9CAC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9597:CNOT2
gene id: 9597:CNOT2
uniprot id: A0A2R9CD80
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9597:LOC100985390
gene id: 9597:LOC100985390
uniprot id: A0A2R9AKG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SLC25A20
gene id: 9597:SLC25A20
uniprot id: A0A2R9AMS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ACVR1
gene id: 9597:ACVR1
uniprot id: A0A2R9BMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9597:PRKG2
gene id: 9597:PRKG2
uniprot id: A0A2R9C2A8
uniprot id: A0A2R9C2R9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9597:ADAMTS10
gene id: 9597:ADAMTS10
uniprot id: A0A2R9CBX6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:PYCR2
gene id: 9597:PYCR2
uniprot id: A0A2R9ABC1
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9597:WFDC12
gene id: 9597:WFDC12
uniprot id: A0A2R8Z9I4
names: Function
messages: Antibacterial protein. Putative acid-stable proteinase inhibitor.

9597:GPAT4
gene id: 9597:GPAT4
uniprot id: A0A2R9A7F5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:PLA2G4A
gene id: 9597:PLA2G4A
uniprot id: A0A2R9CGU6
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9597:DBX2
gene id: 9597:DBX2
uniprot id: A0A2R9BB85
names: Subcellular Location Annotation
messages: Nucleus

9597:FAXC
gene id: 9597:FAXC
uniprot id: A0A2R9C329
names: Similarity
messages: Belongs to the FAX family.

9597:IZUMO1
gene id: 9597:IZUMO1
uniprot id: A0A2R9A1Y2
names: Similarity
messages: Belongs to the Izumo family.

9597:KHDRBS2
gene id: 9597:KHDRBS2
uniprot id: A0A2R9ANP4
uniprot id: A0A2R9AVJ6
names: Similarity
messages: Belongs to the KHDRBS family.

9597:PNOC
gene id: 9597:PNOC
uniprot id: A0A2R9AJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9597:ARPC1B
gene id: 9597:ARPC1B
uniprot id: A0A2R9A5H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9597:HTR1E
gene id: 9597:HTR1E
uniprot id: A0A2R8ZA08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:CNDP2
gene id: 9597:CNDP2
uniprot id: A0A2R9C0F8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9597:FAM229B
gene id: 9597:FAM229B
uniprot id: A0A2R9B2X8
names: Similarity
messages: Belongs to the FAM229 family.

9597:TAS2R38
gene id: 9597:TAS2R38
uniprot id: I0CKB7
uniprot id: Q697L6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9597:L3HYPDH
gene id: 9597:L3HYPDH
uniprot id: A0A2R9BWA8
names: Similarity
messages: Belongs to the proline racemase family.

9597:ESRRA
gene id: 9597:ESRRA
uniprot id: A0A2R9BL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9597:SLC25A15
gene id: 9597:SLC25A15
uniprot id: A0A2R9AKQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:LEFTY2
gene id: 9597:LEFTY2
uniprot id: A0A2R9A9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9597:LOC100984057
gene id: 9597:LOC100984057
uniprot id: A0A2R9AUU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MGAM2
gene id: 9597:MGAM2
uniprot id: A0A2R9B3A5
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SSR4
gene id: 9597:SSR4
uniprot id: A0A2R9CDY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9597:TMEM134
gene id: 9597:TMEM134
uniprot id: A0A2R9BPB8
uniprot id: A0A2R9BYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9597:TRRAP
gene id: 9597:TRRAP
uniprot id: A0A2R9BFY1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

9597:EMX2
gene id: 9597:EMX2
uniprot id: A0A2R9A2P6
names: Subcellular Location Annotation
messages: Nucleus

9597:DNAAF6
gene id: 9597:DNAAF6
uniprot id: A0A2R9CAC2
names: Similarity
messages: Belongs to the PIH1 family.

9597:LOC100975727
gene id: 9597:LOC100975727
uniprot id: A0A2R8ZKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:GPRIN2
gene id: 9597:GPRIN2
uniprot id: A0A2R9AJ69
names: Function
messages: May be involved in neurite outgrowth.

9597:COQ4
gene id: 9597:COQ4
uniprot id: A0A2R9BE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9597:ZSCAN10
gene id: 9597:ZSCAN10
uniprot id: A0A2R9BWK2
names: Subcellular Location Annotation
messages: Nucleus

9597:SMC3
gene id: 9597:SMC3
uniprot id: A0A2R9AH80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9597:PPEF1
gene id: 9597:PPEF1
uniprot id: A0A2R9A238
names: Similarity
messages: Belongs to the PPP phosphatase family.

9597:CAV2
gene id: 9597:CAV2
uniprot id: A0A2R9CAM3
uniprot id: A0A2R9CAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
messages: Membrane
messages: Nucleus
messages: caveola

9597:KRT35
gene id: 9597:KRT35
uniprot id: A0A2R9ATZ6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:LOC100992664
gene id: 9597:LOC100992664
uniprot id: A0A2R8ZPV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:BABAM1
gene id: 9597:BABAM1
uniprot id: A0A2R9A8T6
names: Subcellular Location Annotation
messages: Nucleus

9597:ZNF225
gene id: 9597:ZNF225
uniprot id: A0A2R9BTQ5
names: Function
messages: May be involved in transcriptional regulation.

9597:LYRM7
gene id: 9597:LYRM7
uniprot id: A0A2R9AT14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9597:AKT3
gene id: 9597:AKT3
uniprot id: A0A2R9BCQ8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9597:LOC100970658
gene id: 9597:LOC100970658
uniprot id: A0A2R8ZDB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:EIF2D
gene id: 9597:EIF2D
uniprot id: A0A2R9AWK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9597:MRPL35
gene id: 9597:MRPL35
uniprot id: A0A2R9CE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9597:TNNT3
gene id: 9597:TNNT3
uniprot id: A0A2R9AR16
uniprot id: A0A2R9ARJ3
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9597:BRMS1L
gene id: 9597:BRMS1L
uniprot id: A0A2R9ADS1
names: Subcellular Location Annotation
messages: Nucleus

9597:FARSB
gene id: 9597:FARSB
uniprot id: A0A2R9C2A7
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9597:WSCD2
gene id: 9597:WSCD2
uniprot id: A0A2R9ATF8
names: Similarity
messages: Belongs to the WSCD family.

9597:ITGA2B
gene id: 9597:ITGA2B
uniprot id: A0A2R9BZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:GALC
gene id: 9597:GALC
uniprot id: A0A2R9AG83
uniprot id: A0A2R9AL28
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

9597:TMEM255A
gene id: 9597:TMEM255A
uniprot id: A0A2R9B7X7
uniprot id: A0A2R9BF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9597:PKN1
gene id: 9597:PKN1
uniprot id: A0A2R9BTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9597:NECAP1
gene id: 9597:NECAP1
uniprot id: A0A2R9CG30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9597:THNSL1
gene id: 9597:THNSL1
uniprot id: A0A2R8ZAN4
names: Similarity
messages: Belongs to the threonine synthase family.

9597:SERPINB7
gene id: 9597:SERPINB7
uniprot id: A0A2R9A1V2
names: Similarity
messages: Belongs to the serpin family.

9597:SENP6
gene id: 9597:SENP6
uniprot id: A0A2R9AAE8
uniprot id: A0A2R9AAF0
names: Similarity
messages: Belongs to the peptidase C48 family.

9597:LOC100985450
gene id: 9597:LOC100985450
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:STMN4
gene id: 9597:STMN4
uniprot id: A0A2R9CHU2
uniprot id: A0A2R9CHX5
names: Similarity
messages: Belongs to the stathmin family.

9597:RALY
gene id: 9597:RALY
uniprot id: A0A2R9B3Y0
uniprot id: A0A2R9B8X9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9597:BPNT1
gene id: 9597:BPNT1
uniprot id: A0A2R9AC40
uniprot id: A0A2R9AH02
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:AK6
gene id: 9597:AK6
uniprot id: A0A2R9CGZ2
uniprot id: A0A2R9CJQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9597:ITGAD
gene id: 9597:ITGAD
uniprot id: A0A2R9C3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:TYR
gene id: 9597:TYR
uniprot id: A0A2R9A709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9597:RPAP1
gene id: 9597:RPAP1
uniprot id: A0A2R9B7W3
uniprot id: A0A2R9BA33
names: Similarity
messages: Belongs to the RPAP1 family.

9597:MCM7
gene id: 9597:MCM7
uniprot id: A0A2R9B174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9597:COL4A1
gene id: 9597:COL4A1
uniprot id: A0A2R8ZQ62
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9597:S100A10
gene id: 9597:S100A10
uniprot id: A0A2R9BHV8
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9597:NPLOC4
gene id: 9597:NPLOC4
uniprot id: A0A2R9A043
names: Similarity
messages: Belongs to the NPL4 family.

9597:DNAJC22
gene id: 9597:DNAJC22
uniprot id: A0A2R8ZJ38
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9597:SGSM2
gene id: 9597:SGSM2
uniprot id: A0A2R9BQQ1
uniprot id: A0A2R9BZT2
names: Similarity
messages: Belongs to the RUTBC family.

9597:SLC35D1
gene id: 9597:SLC35D1
uniprot id: A0A2R8ZT85
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100987365
gene id: 9597:LOC100987365
uniprot id: A0A2R9BGD8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:CARMIL1
gene id: 9597:CARMIL1
uniprot id: A0A2R9BSS0
uniprot id: A0A2R9BVI7
uniprot id: A0A2R9BVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9597:PMM1
gene id: 9597:PMM1
uniprot id: A0A2R9B4G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9597:ADAM10
gene id: 9597:ADAM10
uniprot id: A0A2R9C3C4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: adherens junction

9597:FAM221B
gene id: 9597:FAM221B
uniprot id: A0A2R9AYK1
names: Similarity
messages: Belongs to the FAM221 family.

9597:CYP39A1
gene id: 9597:CYP39A1
uniprot id: A0A2R9BGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9597:LOC100985441
gene id: 9597:LOC100985441
uniprot id: A0A2R8ZBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:WNT7A
gene id: 9597:WNT7A
uniprot id: A0A2R9AAY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:QRFPR
gene id: 9597:QRFPR
uniprot id: A0A2R9C677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:PPA2
gene id: 9597:PPA2
uniprot id: A0A2R9CDE9
uniprot id: A0A2R9CNU0
names: Similarity
messages: Belongs to the PPase family.

9597:LOC100976647
gene id: 9597:LOC100976647
uniprot id: A0A2R8ZPJ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:CPNE3
gene id: 9597:CPNE3
uniprot id: A0A2R9A005
names: Similarity
messages: Belongs to the copine family.

9597:SPOPL
gene id: 9597:SPOPL
uniprot id: A0A2R8Z6S0
names: Similarity
messages: Belongs to the Tdpoz family.

9597:ODF1
gene id: 9597:ODF1
uniprot id: A0A2R9BJY7
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9597:LOC100990022
gene id: 9597:LOC100990022
uniprot id: A0A2R8ZJY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ADH6
gene id: 9597:ADH6
uniprot id: A0A2R9B7L7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:MAF1
gene id: 9597:MAF1
uniprot id: A0A2R9BII4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9597:CD3D
gene id: 9597:CD3D
uniprot id: A0A2R8ZGT9
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100986365
gene id: 9597:LOC100986365
uniprot id: A0A2R8ZIQ4
names: Similarity
messages: Belongs to the PRAME family.

9597:MINPP1
gene id: 9597:MINPP1
uniprot id: A0A2R9CJN3
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9597:SLC7A7
gene id: 9597:SLC7A7
uniprot id: A0A2R9BHL1
names: Subcellular Location Annotation
messages: Membrane

9597:TULP3
gene id: 9597:TULP3
uniprot id: A0A2R9A7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9597:ATP5MF
gene id: 9597:ATP5MF
uniprot id: A0A2R9BDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9597:PHKB
gene id: 9597:PHKB
uniprot id: A0A2R9B2B7
uniprot id: A0A2R9B3W5
uniprot id: A0A2R9B406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9597:LOC100996196
gene id: 9597:LOC100996196
uniprot id: A0A2R9ARX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9597:KCNN4
gene id: 9597:KCNN4
uniprot id: A0A2R9AAT6
names: Subcellular Location Annotation
messages: Membrane

9597:BSPH1
gene id: 9597:BSPH1
uniprot id: A0A2R9CKF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:FAM13B
gene id: 9597:FAM13B
uniprot id: A0A2R9ANS0
uniprot id: A0A2R9AT97
names: Similarity
messages: Belongs to the FAM13 family.

9597:GRK5
gene id: 9597:GRK5
uniprot id: A0A2R9A0D5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:ESS2
gene id: 9597:ESS2
uniprot id: A0A2R9AXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9597:SFMBT1
gene id: 9597:SFMBT1
uniprot id: A0A2R8Z8J9
names: Subcellular Location Annotation
messages: Nucleus

9597:CHRNA9
gene id: 9597:CHRNA9
uniprot id: A0A2R8ZXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:ZNF234
gene id: 9597:ZNF234
uniprot id: A0A2R9AG22
names: Function
messages: May be involved in transcriptional regulation.

9597:PER2
gene id: 9597:PER2
uniprot id: A0A2R9CHZ7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:FBLN2
gene id: 9597:FBLN2
uniprot id: A0A2R8ZIS8
uniprot id: A0A2R8ZLT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:TNF
gene id: 9597:TNF
uniprot id: A0A2R8ZGR1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.

9597:HOXD8
gene id: 9597:HOXD8
uniprot id: A0A2R9AXY1
names: Subcellular Location Annotation
messages: Nucleus

9597:CORIN
gene id: 9597:CORIN
uniprot id: A0A2R9APB5
uniprot id: A0A2R9ATW5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ELL3
gene id: 9597:ELL3
uniprot id: A0A2R8ZSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9597:C12H12orf43
gene id: 9597:C12H12orf43
uniprot id: A0A2R9CI08
uniprot id: A0A2R9CKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9597:ACSM4
gene id: 9597:ACSM4
uniprot id: A0A2R9AFR0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:RBP7
gene id: 9597:RBP7
uniprot id: A0A2R9AR81
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:PRF1
gene id: 9597:PRF1
uniprot id: A0A2R9C5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9597:GAA
gene id: 9597:GAA
uniprot id: A0A2R8ZS20
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MRPS16
gene id: 9597:MRPS16
uniprot id: A0A2R8ZAM2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9597:IL17RB
gene id: 9597:IL17RB
uniprot id: A0A2R9C6Y5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:PLXNA3
gene id: 9597:PLXNA3
uniprot id: A0A2R9BG96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:RPL38
gene id: 9597:RPL38
uniprot id: A0A2R9AUE2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9597:POLR3C
gene id: 9597:POLR3C
uniprot id: A0A2R8ZRI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9597:FUT10
gene id: 9597:FUT10
uniprot id: A0A2R9AZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9597:TPM3
gene id: 9597:TPM3
uniprot id: A0A2R9B237
uniprot id: A0A2R9B5U7
uniprot id: A0A2R9B8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:DTNB
gene id: 9597:DTNB
uniprot id: A0A2R9A0F0
uniprot id: A0A2R9A3P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9597:ELF2
gene id: 9597:ELF2
uniprot id: A0A2R8ZG81
uniprot id: A0A2R8ZGN5
uniprot id: A0A2R8ZGP0
uniprot id: A0A2R8ZML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:TM4SF5
gene id: 9597:TM4SF5
uniprot id: A0A2R9A2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9597:PSME4
gene id: 9597:PSME4
uniprot id: A0A2R9C9E5
names: Similarity
messages: Belongs to the BLM10 family.

9597:LHX9
gene id: 9597:LHX9
uniprot id: A0A2R8Z7U1
uniprot id: A0A2R8Z7Z9
names: Subcellular Location Annotation
messages: Nucleus

9597:LNPK
gene id: 9597:LNPK
uniprot id: A0A2R9ABG0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9597:S1PR1
gene id: 9597:S1PR1
uniprot id: A0A2R8ZKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:GLI3
gene id: 9597:GLI3
uniprot id: A0A2R9CIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

9597:FOXP3
gene id: 9597:FOXP3
uniprot id: A0A2R8ZXV7
uniprot id: A0A2R9A1N1
names: Subcellular Location Annotation
messages: Nucleus

9597:HTR4
gene id: 9597:HTR4
uniprot id: A0A2R9C267
uniprot id: A0A2R9C269
uniprot id: A0A2R9C2P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9597:ADAMTS3
gene id: 9597:ADAMTS3
uniprot id: A0A2R9CC15
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:PRDM14
gene id: 9597:PRDM14
uniprot id: A0A2R8ZS07
names: Subcellular Location Annotation
messages: Nucleus

9597:MLN
gene id: 9597:MLN
uniprot id: A0A2R9AQE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9597:HAP1
gene id: 9597:HAP1
uniprot id: A0A2R8ZXS7
uniprot id: A0A2R8ZYW3
names: Subcellular Location Annotation
messages: Early endosome
messages: Mitochondrion

9597:TRIP12
gene id: 9597:TRIP12
uniprot id: A0A2R9CE67
uniprot id: A0A2R9CE74
uniprot id: A0A2R9CPA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9597:LPCAT3
gene id: 9597:LPCAT3
uniprot id: A0A2R9BH33
names: Subcellular Location Annotation
messages: Membrane

9597:SMPD2
gene id: 9597:SMPD2
uniprot id: A0A2R9ANF2
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9597:GPD2
gene id: 9597:GPD2
uniprot id: A0A2R9AFW8
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9597:TRMT2A
gene id: 9597:TRMT2A
uniprot id: A0A2R9CKD7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:COPS6
gene id: 9597:COPS6
uniprot id: A0A2R9CNJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9597:GPR158
gene id: 9597:GPR158
uniprot id: A0A2R9AC25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9597:ODAM
gene id: 9597:ODAM
uniprot id: A0A2R9AZ39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9597:CCNO
gene id: 9597:CCNO
uniprot id: A0A2R8ZXY8
names: Similarity
messages: Belongs to the cyclin family.

9597:ZNF607
gene id: 9597:ZNF607
uniprot id: A0A2R8Z8N5
uniprot id: A0A2R9CF94
names: Function
messages: May be involved in transcriptional regulation.

9597:LAMTOR2
gene id: 9597:LAMTOR2
uniprot id: A0A2R9BH20
uniprot id: A0A2R9BQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9597:A4GNT
gene id: 9597:A4GNT
uniprot id: A0A2R9B7L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9597:CCR6
gene id: 9597:CCR6
uniprot id: A0A2R9B7I6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC103785886
gene id: 9597:LOC103785886
uniprot id: A0A2R8ZKJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ADAM2
gene id: 9597:ADAM2
uniprot id: A0A2R8ZW93
uniprot id: A0A2R9A1V7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

9597:VEGFA
gene id: 9597:VEGFA
uniprot id: A0A2R8ZTA0
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9597:ENTPD2
gene id: 9597:ENTPD2
uniprot id: A0A2R9CEE2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:MOB1B
gene id: 9597:MOB1B
uniprot id: A0A2R9ARS9
uniprot id: A0A2R9AYC4
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:ASXL2
gene id: 9597:ASXL2
uniprot id: A0A2R9C392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9597:HAMP
gene id: 9597:HAMP
uniprot id: A0A2R9BZJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9597:SERPINA7
gene id: 9597:SERPINA7
uniprot id: A0A2R9BCB8
names: Similarity
messages: Belongs to the serpin family.

9597:AP2A1
gene id: 9597:AP2A1
uniprot id: A0A2R8ZNX3
uniprot id: A0A2R8ZUS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9597:GRK1
gene id: 9597:GRK1
uniprot id: A0A2R8ZIW3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:SRPX2
gene id: 9597:SRPX2
uniprot id: A0A2R9BTE1
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9597:VARS1
gene id: 9597:VARS1
uniprot id: A0A2R9AWC1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:RAB33B
gene id: 9597:RAB33B
uniprot id: A0A2R9CHS4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9597:CLIC2
gene id: 9597:CLIC2
uniprot id: A0A2R9C5B1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9597:CCNT2
gene id: 9597:CCNT2
uniprot id: A0A2R9BFQ3
uniprot id: A0A2R9BFR5
names: Similarity
messages: Belongs to the cyclin family.

9597:CD200R1L
gene id: 9597:CD200R1L
uniprot id: A0A2R9CFG5
names: Similarity
messages: Belongs to the CD200R family.

9597:FICD
gene id: 9597:FICD
uniprot id: A0A2R9AM27
names: Similarity
messages: Belongs to the fic family.

9597:CA11
gene id: 9597:CA11
uniprot id: A0A2R9A1F0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9597:LOC103785895
gene id: 9597:LOC103785895
uniprot id: A0A2R8ZQQ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9597:FAM174B
gene id: 9597:FAM174B
uniprot id: A0A2R9B0I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9597:ANAPC10
gene id: 9597:ANAPC10
uniprot id: A0A2R9B1F2
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9597:DNASE2
gene id: 9597:DNASE2
uniprot id: A0A2R9AXV7
names: Similarity
messages: Belongs to the DNase II family.

9597:CYP27B1
gene id: 9597:CYP27B1
uniprot id: A0A2R9ALD4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:SDAD1
gene id: 9597:SDAD1
uniprot id: A0A2R9BSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9597:MRC1
gene id: 9597:MRC1
uniprot id: A0A2R9CHH0
names: Subcellular Location Annotation
messages: Membrane

9597:DGKB
gene id: 9597:DGKB
uniprot id: A0A2R9BCL3
uniprot id: A0A2R9BEZ0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9597:PPM1A
gene id: 9597:PPM1A
uniprot id: A0A2R9BCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9597:IL25
gene id: 9597:IL25
uniprot id: A0A2R8ZT80
uniprot id: A0A2R8ZWI1
names: Similarity
messages: Belongs to the IL-17 family.

9597:STAC
gene id: 9597:STAC
uniprot id: A0A2R9C0J1
names: Subcellular Location Annotation
messages: sarcolemma

9597:ZNF510
gene id: 9597:ZNF510
uniprot id: A0A2R9BRL3
names: Function
messages: May be involved in transcriptional regulation.

9597:SLA
gene id: 9597:SLA
uniprot id: A0A2R9C909
uniprot id: A0A2R9CJR3
names: Subcellular Location Annotation
messages: Cytoplasm

9597:ACTRT2
gene id: 9597:ACTRT2
uniprot id: A0A2R8Z9G4
names: Similarity
messages: Belongs to the actin family.

9597:LPO
gene id: 9597:LPO
uniprot id: A0A2R9B378
uniprot id: A0A2R9B9U1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Secreted

9597:FLOT2
gene id: 9597:FLOT2
uniprot id: A0A2R8ZJ25
uniprot id: A0A2R8ZM31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

9597:MRPL12
gene id: 9597:MRPL12
uniprot id: A0A2R9C9I4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9597:HTR1A
gene id: 9597:HTR1A
uniprot id: A0A2R8ZRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9597:BCCIP
gene id: 9597:BCCIP
uniprot id: A0A2R8ZMB1
uniprot id: A0A2R8ZQI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9597:LOC100968956
gene id: 9597:LOC100968956
uniprot id: A0A2R9CAE0
names: Function
messages: May be involved in transcriptional regulation.

9597:TMPRSS11A
gene id: 9597:TMPRSS11A
uniprot id: A0A2R9C075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9597:CNTNAP2
gene id: 9597:CNTNAP2
uniprot id: A0A2R9A2M7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9597:MIGA2
gene id: 9597:MIGA2
uniprot id: A0A2R9ADA1
names: Similarity
messages: Belongs to the mitoguardin family.

9597:NDUFB4
gene id: 9597:NDUFB4
uniprot id: A0A2R8ZZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:SLC18A2
gene id: 9597:SLC18A2
uniprot id: A0A2R8ZND4
names: Subcellular Location Annotation
messages: Membrane

9597:DCLRE1A
gene id: 9597:DCLRE1A
uniprot id: A0A2R9CJR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9597:RPL36
gene id: 9597:RPL36
uniprot id: A0A2R8ZWN1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9597:TEX261
gene id: 9597:TEX261
uniprot id: A0A2R9BQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9597:IL13
gene id: 9597:IL13
uniprot id: A0A2R9AD54
uniprot id: A0A2R9AD95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9597:GNPTAB
gene id: 9597:GNPTAB
uniprot id: A0A2R9CF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9597:LOC100977815
gene id: 9597:LOC100977815
uniprot id: A0A2R8ZCK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:XPNPEP1
gene id: 9597:XPNPEP1
uniprot id: A0A2R8ZUH3
names: Similarity
messages: Belongs to the peptidase M24B family.

9597:NETO1
gene id: 9597:NETO1
uniprot id: A0A2R8ZPB0
uniprot id: A0A2R8ZQI0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:C19H19orf53
gene id: 9597:C19H19orf53
uniprot id: A0A2R9BTN2
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9597:PRDM15
gene id: 9597:PRDM15
uniprot id: A0A2R9AE29
names: Subcellular Location Annotation
messages: Nucleus

9597:CCL5
gene id: 9597:CCL5
uniprot id: A0A2R9CSX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:SOX10
gene id: 9597:SOX10
uniprot id: A0A2R9A0H5
names: Subcellular Location Annotation
messages: Nucleus

9597:GLUL
gene id: 9597:GLUL
uniprot id: A0A2R9CBD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9597:LSM5
gene id: 9597:LSM5
uniprot id: A0A2R8Z7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9597:ABL2
gene id: 9597:ABL2
uniprot id: A0A2R9CKH6
uniprot id: A0A2R9CMY8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:ETFRF1
gene id: 9597:ETFRF1
uniprot id: A0A2R9BVR7
names: Similarity
messages: Belongs to the complex I LYR family.

9597:NUP35
gene id: 9597:NUP35
uniprot id: A0A2R9BBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9597:PSME3
gene id: 9597:PSME3
uniprot id: A0A2R9CT29
names: Similarity
messages: Belongs to the PA28 family.

9597:CMTM8
gene id: 9597:CMTM8
uniprot id: A0A2R9AGV2
names: Subcellular Location Annotation
messages: Membrane

9597:PIWIL1
gene id: 9597:PIWIL1
uniprot id: A0A2R8ZHG2
names: Similarity
messages: Belongs to the argonaute family.

9597:ALB
gene id: 9597:ALB
uniprot id: A0A2R9CFC1
names: Subcellular Location Annotation
messages: Secreted

9597:CLSTN3
gene id: 9597:CLSTN3
uniprot id: A0A2R9AML8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9597:CREB3L4
gene id: 9597:CREB3L4
uniprot id: A0A2R8ZJH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RRP15
gene id: 9597:RRP15
uniprot id: A0A2R9CKV5
names: Similarity
messages: Belongs to the RRP15 family.

9597:ANAPC15
gene id: 9597:ANAPC15
uniprot id: A0A2R8ZH31
names: Similarity
messages: Belongs to the APC15 family.

9597:MRPL51
gene id: 9597:MRPL51
uniprot id: A0A2R9BXA6
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9597:TRPC5
gene id: 9597:TRPC5
uniprot id: A0A2R9B567
names: Subcellular Location Annotation
messages: Membrane

9597:RAP2C
gene id: 9597:RAP2C
uniprot id: A0A2R9BPU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9597:RPS11
gene id: 9597:RPS11
uniprot id: A0A2R9BSU4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9597:SNX14
gene id: 9597:SNX14
uniprot id: A0A2R9BRD1
uniprot id: A0A2R9BUT4
names: Similarity
messages: Belongs to the sorting nexin family.

9597:ZNF566
gene id: 9597:ZNF566
uniprot id: A0A2R9CHL1
uniprot id: A0A2R9CHP8
names: Function
messages: May be involved in transcriptional regulation.

9597:KCNK5
gene id: 9597:KCNK5
uniprot id: A0A2R8ZIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:PAICS
gene id: 9597:PAICS
uniprot id: A0A2R9B604
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9597:GABARAPL2
gene id: 9597:GABARAPL2
uniprot id: A0A2R9ASH1
names: Similarity
messages: Belongs to the ATG8 family.

9597:VGLL2
gene id: 9597:VGLL2
uniprot id: A0A2R9CH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9597:DDX50
gene id: 9597:DDX50
uniprot id: A0A2R9CC31
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9597:HCRTR1
gene id: 9597:HCRTR1
uniprot id: A0A2R9A4P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:IFI27
gene id: 9597:IFI27
uniprot id: A0A2R9AJH8
uniprot id: A0A2R9AQR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9597:MS4A10
gene id: 9597:MS4A10
uniprot id: A0A2R9A9Y9
names: Similarity
messages: Belongs to the MS4A family.

9597:ATM
gene id: 9597:ATM
uniprot id: A0A2R9A1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.

9597:HOMER3
gene id: 9597:HOMER3
uniprot id: A0A2R9BIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9597:UNC5D
gene id: 9597:UNC5D
uniprot id: A0A2R9CAA5
uniprot id: A0A2R9CCQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9597:DAP3
gene id: 9597:DAP3
uniprot id: A0A2R9AE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9597:CD164
gene id: 9597:CD164
uniprot id: A0A2R9BEK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9597:WIF1
gene id: 9597:WIF1
uniprot id: A0A2R9AG94
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LANCL3
gene id: 9597:LANCL3
uniprot id: A0A2R8ZYM5
uniprot id: A0A2R9A0W6
names: Similarity
messages: Belongs to the LanC-like protein family.

9597:SMAD1
gene id: 9597:SMAD1
uniprot id: A0A2R8ZY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:SLC18B1
gene id: 9597:SLC18B1
uniprot id: A0A2R9C8A3
uniprot id: A0A2R9C8N1
names: Subcellular Location Annotation
messages: Membrane

9597:MRPS17
gene id: 9597:MRPS17
uniprot id: A0A2R9BKT7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9597:DENND6A
gene id: 9597:DENND6A
uniprot id: A0A2R9AW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9597:METTL8
gene id: 9597:METTL8
uniprot id: A0A2R9AB17
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9597:ISX
gene id: 9597:ISX
uniprot id: A0A2R8ZKJ5
names: Subcellular Location Annotation
messages: Nucleus

9597:MVD
gene id: 9597:MVD
uniprot id: A0A2R8ZP16
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9597:PHC3
gene id: 9597:PHC3
uniprot id: A0A2R8ZSC0
names: Subcellular Location Annotation
messages: Nucleus

9597:TRPM1
gene id: 9597:TRPM1
uniprot id: A0A2R9AHK7
uniprot id: A0A2R9AMB0
names: Subcellular Location Annotation
messages: Membrane

9597:DSG1
gene id: 9597:DSG1
uniprot id: A0A2R9C939
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:AMER3
gene id: 9597:AMER3
uniprot id: A0A2R9AY54
names: Similarity
messages: Belongs to the Amer family.

9597:FAM131A
gene id: 9597:FAM131A
uniprot id: A0A2R9BJG3
names: Similarity
messages: Belongs to the FAM131 family.

9597:SELP
gene id: 9597:SELP
uniprot id: A0A2R9AUS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LOC100991849
gene id: 9597:LOC100991849
uniprot id: A0A2R9BWP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9597:PARVA
gene id: 9597:PARVA
uniprot id: A0A2R9BJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9597:SERPINE2
gene id: 9597:SERPINE2
uniprot id: A0A2R9C5Q1
names: Similarity
messages: Belongs to the serpin family.

9597:GTF2A1
gene id: 9597:GTF2A1
uniprot id: A0A2R9BJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9597:RAB9B
gene id: 9597:RAB9B
uniprot id: A0A2R8ZB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9597:NANOS2
gene id: 9597:NANOS2
uniprot id: A0A2R8ZIX2
names: Similarity
messages: Belongs to the nanos family.

9597:TECPR1
gene id: 9597:TECPR1
uniprot id: A0A2R9BF29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

9597:PRDX5
gene id: 9597:PRDX5
uniprot id: A0A2R9AGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9597:TAS2R1
gene id: 9597:TAS2R1
uniprot id: Q646G9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:PMEPA1
gene id: 9597:PMEPA1
uniprot id: A0A2R9BYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9597:LOC100986388
gene id: 9597:LOC100986388
uniprot id: A0A2R9A0L9
uniprot id: A0A2R9A618
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:GRIA1
gene id: 9597:GRIA1
uniprot id: A0A2R9A0F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:CDC37
gene id: 9597:CDC37
uniprot id: A0A2R9C7D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9597:CCR4
gene id: 9597:CCR4
uniprot id: A0A2R8ZA62
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:ADGRD1
gene id: 9597:ADGRD1
uniprot id: A0A2R8ZIA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:POLR2B
gene id: 9597:POLR2B
uniprot id: A0A2R9BZK6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9597:TP53INP2
gene id: 9597:TP53INP2
uniprot id: A0A2R8ZCD2
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9597:HOXA1
gene id: 9597:HOXA1
uniprot id: A0A2R8Z5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9597:SNRPF
gene id: 9597:SNRPF
uniprot id: A0A2R8Z7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9597:CXCL9
gene id: 9597:CXCL9
uniprot id: A0A2R9BUU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:MRPL4
gene id: 9597:MRPL4
uniprot id: A0A2R9C897
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9597:PCYOX1
gene id: 9597:PCYOX1
uniprot id: A0A2R9BF23
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9597:LOC100994559
gene id: 9597:LOC100994559
uniprot id: A0A2R9AES3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:IRAK4
gene id: 9597:IRAK4
uniprot id: A0A2R8ZXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9597:HACD4
gene id: 9597:HACD4
uniprot id: A0A2R9BPY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PLOD3
gene id: 9597:PLOD3
uniprot id: A0A2R9BNE3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9597:PRM1
gene id: 9597:PRM1
uniprot id: P35308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

9597:GDPD5
gene id: 9597:GDPD5
uniprot id: A0A2R9CC92
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:AKT2
gene id: 9597:AKT2
uniprot id: A0A2R9A1U2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9597:KRT36
gene id: 9597:KRT36
uniprot id: A0A2R9BRN9
names: Similarity
messages: Belongs to the intermediate filament family.

9597:VPS16
gene id: 9597:VPS16
uniprot id: A0A2R9B9X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9597:CCDC39
gene id: 9597:CCDC39
uniprot id: A0A2R8ZX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9597:LOC100983651
gene id: 9597:LOC100983651
uniprot id: A0A2R9B5J0
uniprot id: A0A2R9B5J2
uniprot id: A0A2R9B9A3
uniprot id: A0A2R9BCL5
names: Function
messages: May be involved in transcriptional regulation.

9597:CLDN14
gene id: 9597:CLDN14
uniprot id: A0A2R9AUN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:EIF1AD
gene id: 9597:EIF1AD
uniprot id: A0A2R8Z714
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9597:ZNF81
gene id: 9597:ZNF81
uniprot id: A0A2R8ZW46
names: Function
messages: May be involved in transcriptional regulation.

9597:P4HA2
gene id: 9597:P4HA2
uniprot id: A0A2R9A1T5
uniprot id: A0A2R9A6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9597:ATG4D
gene id: 9597:ATG4D
uniprot id: A0A2R9AJ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9597:USP33
gene id: 9597:USP33
uniprot id: A0A2R9CFV2
uniprot id: A0A2R9CQ86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9597:EPHA4
gene id: 9597:EPHA4
uniprot id: A0A2R9CME8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9597:ZNF215
gene id: 9597:ZNF215
uniprot id: A0A2R9B819
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:POU4F3
gene id: 9597:POU4F3
uniprot id: A0A2R9CJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:GRHPR
gene id: 9597:GRHPR
uniprot id: A0A2R9BIX8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9597:WTAP
gene id: 9597:WTAP
uniprot id: A0A2R9A685
uniprot id: A0A2R9A694
names: Similarity
messages: Belongs to the fl(2)d family.

9597:C19H19orf12
gene id: 9597:C19H19orf12
uniprot id: A0A2R9A8G0
uniprot id: A0A2R9A9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9597:ADAM19
gene id: 9597:ADAM19
uniprot id: A0A2R9AQB2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HOXB9
gene id: 9597:HOXB9
uniprot id: A0A2R8ZZY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9597:PATZ1
gene id: 9597:PATZ1
uniprot id: A0A2R9ARW0
uniprot id: A0A2R9ASE3
uniprot id: A0A2R9AYE5
names: Subcellular Location Annotation
messages: Nucleus

9597:XPR1
gene id: 9597:XPR1
uniprot id: A0A2R8ZLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9597:ZNF850
gene id: 9597:ZNF850
uniprot id: A0A2R9BS37
names: Function
messages: May be involved in transcriptional regulation.

9597:TFB1M
gene id: 9597:TFB1M
uniprot id: A0A2R9ADI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9597:LOC100980884
gene id: 9597:LOC100980884
uniprot id: A0A2R8Z8L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ERCC3
gene id: 9597:ERCC3
uniprot id: A0A2R9B901
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9597:HIGD1A
gene id: 9597:HIGD1A
uniprot id: A0A2R8ZSI2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:ELOVL4
gene id: 9597:ELOVL4
uniprot id: A0A2R9CF78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:PPARGC1A
gene id: 9597:PPARGC1A
uniprot id: A0A2R9B0J6
uniprot id: A0A2R9B1U3
names: Subcellular Location Annotation
messages: PML body

9597:ATP6V0C
gene id: 9597:ATP6V0C
uniprot id: A0A2R9C662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9597:LOC100975109
gene id: 9597:LOC100975109
uniprot id: A0A2R8ZNA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ZNF124
gene id: 9597:ZNF124
uniprot id: A0A2R9ASX3
uniprot id: A0A2R9ATA1
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC103785057
gene id: 9597:LOC103785057
uniprot id: A0A2R8ZM75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9597:ADCY2
gene id: 9597:ADCY2
uniprot id: A0A2R9B9K9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9597:LOC100989331
gene id: 9597:LOC100989331
uniprot id: A0A2R8ZP44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:PPFIA3
gene id: 9597:PPFIA3
uniprot id: A0A2R8ZQ03
uniprot id: A0A2R8ZT21
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9597:ADA2
gene id: 9597:ADA2
uniprot id: A0A2R9BSU9
uniprot id: A0A2R9BSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9597:MEN1
gene id: 9597:MEN1
uniprot id: A0A2R8ZTC6
names: Subcellular Location Annotation
messages: Nucleus

9597:MGST2
gene id: 9597:MGST2
uniprot id: A0A2R9B5L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ZDHHC16
gene id: 9597:ZDHHC16
uniprot id: A0A2R9AAW1
uniprot id: A0A2R9AGG3
uniprot id: A0A2R9AGG7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:TSC22D1
gene id: 9597:TSC22D1
uniprot id: A0A2R9BWG4
uniprot id: A0A2R9BWH4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9597:CYP4F22
gene id: 9597:CYP4F22
uniprot id: A0A2R9C8I6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:GTPBP4
gene id: 9597:GTPBP4
uniprot id: A0A2R9CCI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9597:RAD50
gene id: 9597:RAD50
uniprot id: A0A2R9ACX5
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9597:ARL5A
gene id: 9597:ARL5A
uniprot id: A0A2R9AT82
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:RASGRP4
gene id: 9597:RASGRP4
uniprot id: A0A2R9CKI3
names: Similarity
messages: Belongs to the RASGRP family.

9597:RPL6
gene id: 9597:RPL6
uniprot id: A0A2R8ZAQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9597:SNAPC3
gene id: 9597:SNAPC3
uniprot id: A0A2R8ZM08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9597:PRSS16
gene id: 9597:PRSS16
uniprot id: A0A2R9A5V9
names: Similarity
messages: Belongs to the peptidase S28 family.

9597:PFKFB4
gene id: 9597:PFKFB4
uniprot id: A0A2R9C0V9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9597:TIRAP
gene id: 9597:TIRAP
uniprot id: B3Y686
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9597:MYOF
gene id: 9597:MYOF
uniprot id: A0A2R9C196
uniprot id: A0A2R9C1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:CDC5L
gene id: 9597:CDC5L
uniprot id: A0A2R9APB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

9597:GLYR1
gene id: 9597:GLYR1
uniprot id: A0A2R9BC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9597:RNMT
gene id: 9597:RNMT
uniprot id: A0A2R8ZPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9597:RHBDD1
gene id: 9597:RHBDD1
uniprot id: A0A2R9CS20
names: Subcellular Location Annotation
messages: Membrane

9597:HMGCLL1
gene id: 9597:HMGCLL1
uniprot id: A0A2R9ALA9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9597:ST3GAL4
gene id: 9597:ST3GAL4
uniprot id: A0A2R9A9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:SLC9A1
gene id: 9597:SLC9A1
uniprot id: A0A2R9CKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane

9597:IKBKE
gene id: 9597:IKBKE
uniprot id: A0A2R9BQ59
names: Subcellular Location Annotation
messages: Cytoplasm

9597:TGM5
gene id: 9597:TGM5
uniprot id: A0A2R8Z5W5
uniprot id: A0A2R8Z9Q4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:MEIS1
gene id: 9597:MEIS1
uniprot id: A0A2R9BFH6
uniprot id: A0A2R9BFJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9597:POLD1
gene id: 9597:POLD1
uniprot id: A0A2R9A9F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9597:PLSCR2
gene id: 9597:PLSCR2
uniprot id: A0A2R8ZPV5
uniprot id: A0A2R8ZR15
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9597:SNURF
gene id: 9597:SNURF
uniprot id: A0A2R8ZV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9597:MYG1
gene id: 9597:MYG1
uniprot id: A0A2R9C926
names: Similarity
messages: Belongs to the MYG1 family.

9597:PROKR2
gene id: 9597:PROKR2
uniprot id: A0A2R9B0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:NDUFA3
gene id: 9597:NDUFA3
uniprot id: A0A2R9B995
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ROM1
gene id: 9597:ROM1
uniprot id: A0A2R9B4T6
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9597:GPS1
gene id: 9597:GPS1
uniprot id: A0A2R9BC89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN1 family.
messages: Cytoplasm
messages: Nucleus

9597:SMC4
gene id: 9597:SMC4
uniprot id: A0A2R9CEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9597:IZUMO4
gene id: 9597:IZUMO4
uniprot id: A0A2R9CA91
uniprot id: A0A2R9CAA8
names: Similarity
messages: Belongs to the Izumo family.

9597:ENTPD7
gene id: 9597:ENTPD7
uniprot id: A0A2R9B779
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:SLC12A6
gene id: 9597:SLC12A6
uniprot id: A0A2R9AVG1
uniprot id: A0A2R9AVH9
uniprot id: A0A2R9AVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9597:ABRACL
gene id: 9597:ABRACL
uniprot id: A0A2R8ZQX7
names: Similarity
messages: Belongs to the costars family.

9597:MDM2
gene id: 9597:MDM2
uniprot id: A0A2R9AQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9597:MRTO4
gene id: 9597:MRTO4
uniprot id: A0A2R9CMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9597:CLTRN
gene id: 9597:CLTRN
uniprot id: A0A2R9A7Z1
names: Subcellular Location Annotation
messages: Membrane

9597:ACE2
gene id: 9597:ACE2
uniprot id: A0A2R9BJK0
uniprot id: A0A2R9BKD8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9597:PEDS1
gene id: 9597:PEDS1
uniprot id: A0A2R9A6Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9597:CHMP4C
gene id: 9597:CHMP4C
uniprot id: A0A2R9C9K3
names: Similarity
messages: Belongs to the SNF7 family.

9597:HSPA13
gene id: 9597:HSPA13
uniprot id: A0A2R9CIK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9597:ITGA8
gene id: 9597:ITGA8
uniprot id: A0A2R9AJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:NPC2
gene id: 9597:NPC2
uniprot id: A0A2R9BTI8
uniprot id: A0A2R9BU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9597:KIAA1191
gene id: 9597:KIAA1191
uniprot id: A0A2R8ZMV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9597:TMEM80
gene id: 9597:TMEM80
uniprot id: A0A2R9AM72
names: Subcellular Location Annotation
messages: Membrane

9597:KDM4C
gene id: 9597:KDM4C
uniprot id: A0A2R9CC08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9597:BTK
gene id: 9597:BTK
uniprot id: A0A2R9BPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:LYG1
gene id: 9597:LYG1
uniprot id: A0A2R9B453
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9597:MGAT4D
gene id: 9597:MGAT4D
uniprot id: A0A2R9BC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:SPTLC3
gene id: 9597:SPTLC3
uniprot id: A0A2R9BLL9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9597:CD40
gene id: 9597:CD40
uniprot id: A0A2R9C4Y2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:SLC41A2
gene id: 9597:SLC41A2
uniprot id: A0A2R9CBK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9597:LOC100994024
gene id: 9597:LOC100994024
uniprot id: A0A2R8ZHV4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SLC35C1
gene id: 9597:SLC35C1
uniprot id: A0A2R9BVS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9597:PRDX2
gene id: 9597:PRDX2
uniprot id: A0A2R9B3Q2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9597:CD79A
gene id: 9597:CD79A
uniprot id: A0A2R9BXX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:PTPN2
gene id: 9597:PTPN2
uniprot id: A0A2R9BT42
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9597:EPAS1
gene id: 9597:EPAS1
uniprot id: A0A2R9BIT2
names: Subcellular Location Annotation
messages: Nucleus speckle

9597:ISOC2
gene id: 9597:ISOC2
uniprot id: A0A2R8ZLI5
uniprot id: A0A2R8ZNA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isochorismatase family.
messages: Cytoplasm
messages: Interacts with CDKN2A.
messages: Nucleus

9597:LYZ
gene id: 9597:LYZ
uniprot id: P61627
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
messages: Monomer.
messages: Secreted

9597:IDI2
gene id: 9597:IDI2
uniprot id: A0A2R9CAI9
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9597:EPHB1
gene id: 9597:EPHB1
uniprot id: A0A2R8ZM22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9597:SCG5
gene id: 9597:SCG5
uniprot id: A0A2R9CFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9597:PHKG2
gene id: 9597:PHKG2
uniprot id: A0A2R9B805
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9597:ART5
gene id: 9597:ART5
uniprot id: A0A2R8ZSC8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9597:LOC100974311
gene id: 9597:LOC100974311
uniprot id: A0A2R8ZE83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FER1L5
gene id: 9597:FER1L5
uniprot id: A0A2R9A500
names: Similarity
messages: Belongs to the ferlin family.

9597:LOC100977178
gene id: 9597:LOC100977178
uniprot id: A0A2R9A4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9597:LOC100993131
gene id: 9597:LOC100993131
uniprot id: A0A2R9AF88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9597:SLC30A5
gene id: 9597:SLC30A5
uniprot id: A0A2R9AVT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9597:CEP57L1
gene id: 9597:CEP57L1
uniprot id: A0A2R9CF14
names: Similarity
messages: Belongs to the translokin family.

9597:IFT43
gene id: 9597:IFT43
uniprot id: A0A2R9B5V4
names: Similarity
messages: Belongs to the IFT43 family.

9597:MPP7
gene id: 9597:MPP7
uniprot id: A0A2R9AP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9597:MAP7D3
gene id: 9597:MAP7D3
uniprot id: A0A2R9AQK5
names: Similarity
messages: Belongs to the MAP7 family.

9597:DDI1
gene id: 9597:DDI1
uniprot id: A0A2R8ZIX9
names: Similarity
messages: Belongs to the DDI1 family.

9597:E2F2
gene id: 9597:E2F2
uniprot id: A0A2R9C653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:LCE3C
gene id: 9597:LCE3C
uniprot id: A0A2R8ZHF2
names: Similarity
messages: Belongs to the LCE family.

9597:TRPV1
gene id: 9597:TRPV1
uniprot id: A0A2R8Z9D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendritic spine membrane

9597:ELF1
gene id: 9597:ELF1
uniprot id: A0A2R9AQQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:RIF1
gene id: 9597:RIF1
uniprot id: A0A2R8ZLP8
uniprot id: A0A2R8ZPE7
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9597:SERPINB9
gene id: 9597:SERPINB9
uniprot id: A0A2R9B0Y4
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9597:TMEM263
gene id: 9597:TMEM263
uniprot id: A0A2R8Z9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9597:SOSTDC1
gene id: 9597:SOSTDC1
uniprot id: A0A2R9B357
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ST3GAL6
gene id: 9597:ST3GAL6
uniprot id: A0A2R8Z6P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LOC100984043
gene id: 9597:LOC100984043
uniprot id: A0A2R9A954
names: Function
messages: May be involved in transcriptional regulation.

9597:NIBAN2
gene id: 9597:NIBAN2
uniprot id: A0A2R9APM5
names: Similarity
messages: Belongs to the Niban family.

9597:TTC30A
gene id: 9597:TTC30A
uniprot id: A0A2R8ZMV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9597:ACADL
gene id: 9597:ACADL
uniprot id: A0A2R9B7K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9597:AHR
gene id: 9597:AHR
uniprot id: A0A2R9AFN6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:TFE3
gene id: 9597:TFE3
uniprot id: A0A2R9A329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9597:SLC6A6
gene id: 9597:SLC6A6
uniprot id: A0A2R9C9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9597:LOC100989831
gene id: 9597:LOC100989831
uniprot id: A0A2R8ZJJ5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:NES
gene id: 9597:NES
uniprot id: A0A2R9B9M3
names: Similarity
messages: Belongs to the intermediate filament family.

9597:SPTAN1
gene id: 9597:SPTAN1
uniprot id: A0A2R9BEI2
uniprot id: A0A2R9BEJ7
uniprot id: A0A2R9BH32
uniprot id: A0A2R9BH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9597:AADAC
gene id: 9597:AADAC
uniprot id: A0A2R9AXS8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9597:LOC100979846
gene id: 9597:LOC100979846
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:IMMT
gene id: 9597:IMMT
uniprot id: A0A2R9AJI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9597:FOXB1
gene id: 9597:FOXB1
uniprot id: A0A2R8ZKY7
names: Subcellular Location Annotation
messages: Nucleus

9597:KIF3A
gene id: 9597:KIF3A
uniprot id: A0A2R9BCA2
uniprot id: A0A2R9BDL2
uniprot id: A0A2R9BKR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:BTBD10
gene id: 9597:BTBD10
uniprot id: A0A2R8ZGH8
uniprot id: A0A2R8ZMT5
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LMF2
gene id: 9597:LMF2
uniprot id: A0A2R9AVN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9597:LOC100968416
gene id: 9597:LOC100968416
uniprot id: A0A2R8ZFR6
names: Similarity
messages: Belongs to the FAM154 family.

9597:ERCC2
gene id: 9597:ERCC2
uniprot id: A0A2R9CT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9597:LOC100984360
gene id: 9597:LOC100984360
uniprot id: A0A2R8ZF70
names: Subcellular Location Annotation
messages: Nucleus

9597:MTRF1L
gene id: 9597:MTRF1L
uniprot id: A0A2R9AG16
uniprot id: A0A2R9AH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9597:DMAP1
gene id: 9597:DMAP1
uniprot id: A0A2R9BEF6
names: Subcellular Location Annotation
messages: Nucleus

9597:PRKAG1
gene id: 9597:PRKAG1
uniprot id: A0A2R9CE80
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9597:CCR2
gene id: 9597:CCR2
uniprot id: A0A2R8ZHL5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:CACNB3
gene id: 9597:CACNB3
uniprot id: A0A2R8ZCD4
uniprot id: A0A2R8ZCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9597:ZC3H12C
gene id: 9597:ZC3H12C
uniprot id: A0A2R9C9A0
names: Similarity
messages: Belongs to the ZC3H12 family.

9597:TDP1
gene id: 9597:TDP1
uniprot id: A0A2R9A582
uniprot id: A0A2R9AAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9597:PSMD3
gene id: 9597:PSMD3
uniprot id: A0A2R9A3G8
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9597:RFC1
gene id: 9597:RFC1
uniprot id: A0A2R9C9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9597:CXCR2
gene id: 9597:CXCR2
uniprot id: A0A2R8ZGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:CGA
gene id: 9597:CGA
uniprot id: A0A2R9A0T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

9597:NEIL1
gene id: 9597:NEIL1
uniprot id: A0A2R9BXT0
names: Similarity
messages: Belongs to the FPG family.

9597:SNX18
gene id: 9597:SNX18
uniprot id: A0A2R9AWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9597:SMAD3
gene id: 9597:SMAD3
uniprot id: A0A2R9AV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:ST6GALNAC4
gene id: 9597:ST6GALNAC4
uniprot id: A0A2R9CDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:RWDD3
gene id: 9597:RWDD3
uniprot id: A0A2R8ZTP1
uniprot id: A0A2R8ZUW1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:FAM167A
gene id: 9597:FAM167A
uniprot id: A0A2R8ZHJ9
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9597:CLP1
gene id: 9597:CLP1
uniprot id: A0A2R9C6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9597:BCLAF3
gene id: 9597:BCLAF3
uniprot id: A0A2R9C7Q7
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9597:ERC1
gene id: 9597:ERC1
uniprot id: A0A2R9AZ11
uniprot id: A0A2R9AZN4
uniprot id: A0A2R9B2T2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:TONSL
gene id: 9597:TONSL
uniprot id: A0A2R9AZE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9597:ADI1
gene id: 9597:ADI1
uniprot id: A0A2R9AS51
uniprot id: A0A2R9AYN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9597:PGLS
gene id: 9597:PGLS
uniprot id: A0A2R8ZUQ4
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9597:PKM
gene id: 9597:PKM
uniprot id: A0A2R9C418
uniprot id: A0A2R9C424
uniprot id: A0A2R9CED5
names: Similarity
messages: Belongs to the pyruvate kinase family.

9597:MC2R
gene id: 9597:MC2R
uniprot id: A0A2R8Z669
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

9597:CHRNA2
gene id: 9597:CHRNA2
uniprot id: A0A2R9C9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:ADAMTS1
gene id: 9597:ADAMTS1
uniprot id: A0A2R8Z755
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:MYT1L
gene id: 9597:MYT1L
uniprot id: A0A2R8ZQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9597:SSTR3
gene id: 9597:SSTR3
uniprot id: A0A2R8ZR62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:KDM1B
gene id: 9597:KDM1B
uniprot id: A0A2R9C6J0
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9597:TBCC
gene id: 9597:TBCC
uniprot id: A0A2R8Z8R5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9597:UNK
gene id: 9597:UNK
uniprot id: A0A2R9APG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9597:PRR20G
gene id: 9597:PRR20G
uniprot id: A0A2R9BIV6
names: Similarity
messages: Belongs to the PRR20 family.

9597:LOC100988821
gene id: 9597:LOC100988821
uniprot id: A0A2R8ZH37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ARL6IP5
gene id: 9597:ARL6IP5
uniprot id: A0A2R9AYA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9597:YWHAQ
gene id: 9597:YWHAQ
uniprot id: A0A2R9CFU0
names: Similarity
messages: Belongs to the 14-3-3 family.

9597:VPS72
gene id: 9597:VPS72
uniprot id: A0A2R9BHJ9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9597:BEST2
gene id: 9597:BEST2
uniprot id: A0A2R9BDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:AGA
gene id: 9597:AGA
uniprot id: A0A2R9BM07
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9597:MIF
gene id: 9597:MIF
uniprot id: A0A2R9AQ00
names: Similarity
messages: Belongs to the MIF family.

9597:PAMR1
gene id: 9597:PAMR1
uniprot id: A0A2R8ZP49
uniprot id: A0A2R8ZQC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SPTLC2
gene id: 9597:SPTLC2
uniprot id: A0A2R8ZTG0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9597:LOC100976792
gene id: 9597:LOC100976792
uniprot id: A0A2R8ZIV6
names: Similarity
messages: Belongs to the LCE family.

9597:DPH1
gene id: 9597:DPH1
uniprot id: A0A2R9AWE5
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9597:CAP1
gene id: 9597:CAP1
uniprot id: A0A2R9AZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9597:COPB1
gene id: 9597:COPB1
uniprot id: A0A2R9BT66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9597:TRAPPC11
gene id: 9597:TRAPPC11
uniprot id: A0A2R9A614
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9597:SCN7A
gene id: 9597:SCN7A
uniprot id: A0A2R9AAX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9597:SLC22A8
gene id: 9597:SLC22A8
uniprot id: A0A2R9C641
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9597:FAM149B1
gene id: 9597:FAM149B1
uniprot id: A0A2R9BYZ0
names: Similarity
messages: Belongs to the FAM149 family.

9597:RASSF5
gene id: 9597:RASSF5
uniprot id: A0A2R9A9R2
names: Subcellular Location Annotation
messages: cytoskeleton

9597:ZSCAN30
gene id: 9597:ZSCAN30
uniprot id: A0A2R9CB23
names: Subcellular Location Annotation
messages: Nucleus

9597:MX2
gene id: 9597:MX2
uniprot id: A0A2R9AMN8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9597:UNC5C
gene id: 9597:UNC5C
uniprot id: A0A2R9C6D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9597:TTLL1
gene id: 9597:TTLL1
uniprot id: A0A2R9C6E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9597:KPNA3
gene id: 9597:KPNA3
uniprot id: A0A2R9AZF8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9597:SEMA4F
gene id: 9597:SEMA4F
uniprot id: A0A2R9CL15
uniprot id: A0A2R9CL37
uniprot id: A0A2R9CNB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100988840
gene id: 9597:LOC100988840
uniprot id: A0A2R9B807
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:DCLK1
gene id: 9597:DCLK1
uniprot id: A0A2R9BKT5
uniprot id: A0A2R9BPD2
uniprot id: A0A2R9BUP3
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9597:ABI1
gene id: 9597:ABI1
uniprot id: A0A2R9BPX0
uniprot id: A0A2R9BPY7
uniprot id: A0A2R9BQM8
uniprot id: A0A2R9BTE7
uniprot id: A0A2R9BYZ2
uniprot id: A0A2R9BYZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9597:METTL4
gene id: 9597:METTL4
uniprot id: A0A2R9ACH1
names: Similarity
messages: Belongs to the MT-A70-like family.

9597:CPQ
gene id: 9597:CPQ
uniprot id: A0A2R9ASH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome
messages: Secreted

9597:NGFR
gene id: 9597:NGFR
uniprot id: A0A2R9BW44
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:BBS4
gene id: 9597:BBS4
uniprot id: A0A2R9AZX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

9597:ZNF471
gene id: 9597:ZNF471
uniprot id: A0A2R8Z6X5
names: Function
messages: May be involved in transcriptional regulation.

9597:LBR
gene id: 9597:LBR
uniprot id: A0A2R9A887
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9597:RTRAF
gene id: 9597:RTRAF
uniprot id: A0A2R9AEQ8
names: Similarity
messages: Belongs to the RTRAF family.

9597:PLOD2
gene id: 9597:PLOD2
uniprot id: A0A2R9BUL7
uniprot id: A0A2R9BV87
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9597:MKS1
gene id: 9597:MKS1
uniprot id: A0A2R8ZTG8
names: Subcellular Location Annotation
messages: cilium basal body

9597:NOTCH1
gene id: 9597:NOTCH1
uniprot id: A0A2R9BUT9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9597:SCGB2A2
gene id: 9597:SCGB2A2
uniprot id: A0A2R9BRF9
names: Subcellular Location Annotation
messages: Secreted

9597:CRYGC
gene id: 9597:CRYGC
uniprot id: A0A2R9A6L2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:UBE2C
gene id: 9597:UBE2C
uniprot id: A0A2R9AJ19
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:XKR9
gene id: 9597:XKR9
uniprot id: A0A2R9B9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9597:GMDS
gene id: 9597:GMDS
uniprot id: A0A2R8ZSP9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9597:VCL
gene id: 9597:VCL
uniprot id: A0A2R9CAL0
uniprot id: A0A2R9CAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9597:CAMSAP2
gene id: 9597:CAMSAP2
uniprot id: A0A2R8ZV42
uniprot id: A0A2R8ZWB3
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9597:PEX1
gene id: 9597:PEX1
uniprot id: A0A2R9C762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9597:ZSCAN20
gene id: 9597:ZSCAN20
uniprot id: A0A2R8ZK93
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:VEGFD
gene id: 9597:VEGFD
uniprot id: A0A2R9C7K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9597:CALCRL
gene id: 9597:CALCRL
uniprot id: A0A2R9BXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9597:DSC3
gene id: 9597:DSC3
uniprot id: A0A2R9C429
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:ZRANB2
gene id: 9597:ZRANB2
uniprot id: A0A2R9BEH2
uniprot id: A0A2R9BMY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9597:ZNF300
gene id: 9597:ZNF300
uniprot id: A0A2R9AP07
names: Function
messages: May be involved in transcriptional regulation.

9597:FADS1
gene id: 9597:FADS1
uniprot id: A0A2R9CGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9597:LOC100989229
gene id: 9597:LOC100989229
uniprot id: A0A2R8ZHV5
names: Subunit
messages: Interacts with hair keratins.

9597:LOC100968172
gene id: 9597:LOC100968172
uniprot id: A0A2R9CDR3
names: Function
messages: May be involved in transcriptional regulation.

9597:ZNF782
gene id: 9597:ZNF782
uniprot id: A0A2R9BXM1
names: Function
messages: May be involved in transcriptional regulation.

9597:ZSCAN5B
gene id: 9597:ZSCAN5B
uniprot id: A0A2R8ZAP5
names: Subcellular Location Annotation
messages: Nucleus

9597:DDAH2
gene id: 9597:DDAH2
uniprot id: A0A2R8ZJA1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9597:CSE1L
gene id: 9597:CSE1L
uniprot id: A0A2R9BNT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9597:CNDP1
gene id: 9597:CNDP1
uniprot id: A0A2R9AT56
uniprot id: A0A2R9C0F8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9597:CREB5
gene id: 9597:CREB5
uniprot id: A0A2R9ACK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9597:RORC
gene id: 9597:RORC
uniprot id: A0A2R8ZTF3
uniprot id: A0A2R8ZY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:ACY1
gene id: 9597:ACY1
uniprot id: A0A2R8ZDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9597:PPP6R2
gene id: 9597:PPP6R2
uniprot id: A0A2R9A8P5
names: Similarity
messages: Belongs to the SAPS family.

9597:LOC100969533
gene id: 9597:LOC100969533
uniprot id: A0A2R9AFU1
names: Similarity
messages: Belongs to the histone H2B family.

9597:SIM1
gene id: 9597:SIM1
uniprot id: A0A2R8ZHR3
names: Subcellular Location Annotation
messages: Nucleus

9597:FASN
gene id: 9597:FASN
uniprot id: A0A2R9CIH4
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

9597:ZSCAN26
gene id: 9597:ZSCAN26
uniprot id: A0A2R8ZIE1
names: Subcellular Location Annotation
messages: Nucleus

9597:SV2C
gene id: 9597:SV2C
uniprot id: A0A2R9CB55
uniprot id: A0A2R9CLS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9597:PITRM1
gene id: 9597:PITRM1
uniprot id: A0A2R9A2G5
names: Subunit
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

9597:AP3S2
gene id: 9597:AP3S2
uniprot id: A0A2R9CAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9597:IDO2
gene id: 9597:IDO2
uniprot id: A0A2R9BPN0
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9597:CCNJ
gene id: 9597:CCNJ
uniprot id: A0A2R9BUV0
uniprot id: A0A2R9BUV5
names: Similarity
messages: Belongs to the cyclin family.

9597:STATH
gene id: 9597:STATH
uniprot id: A0A2R9B880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
messages: Secreted

9597:PGAP1
gene id: 9597:PGAP1
uniprot id: A0A2R9BTW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9597:ATP5F1A
gene id: 9597:ATP5F1A
uniprot id: A0A2R9AEQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9597:IL19
gene id: 9597:IL19
uniprot id: A0A2R9B3D8
uniprot id: A0A2R9B4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9597:MST1R
gene id: 9597:MST1R
uniprot id: A0A2R9AIE6
uniprot id: A0A2R9AM93
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:SLC25A35
gene id: 9597:SLC25A35
uniprot id: A0A2R9AUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ZNF527
gene id: 9597:ZNF527
uniprot id: A0A2R9BAB0
names: Function
messages: May be involved in transcriptional regulation.

9597:CBX1
gene id: 9597:CBX1
uniprot id: A0A2R9AGT2
names: Subcellular Location Annotation
messages: Nucleus

9597:GPR15
gene id: 9597:GPR15
uniprot id: A0A2R8ZKQ7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:PDCL2
gene id: 9597:PDCL2
uniprot id: A0A2R9BN33
names: Similarity
messages: Belongs to the phosducin family.

9597:LOC100991867
gene id: 9597:LOC100991867
uniprot id: A0A2R9BU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9597:ATP2C1
gene id: 9597:ATP2C1
uniprot id: A0A2R9AU76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9597:LOC100991254
gene id: 9597:LOC100991254
uniprot id: A0A2R9B668
uniprot id: A0A2R9BDB4
names: Similarity
messages: Belongs to the filamin family.

9597:VPS8
gene id: 9597:VPS8
uniprot id: A0A2R9BQE6
uniprot id: A0A2R9BTV3
names: Similarity
messages: Belongs to the VPS8 family.

9597:PLCD4
gene id: 9597:PLCD4
uniprot id: A0A2R9BW26
uniprot id: A0A2R9C5Q7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9597:ABCG4
gene id: 9597:ABCG4
uniprot id: A0A2R8ZTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9597:RHBG
gene id: 9597:RHBG
uniprot id: A0A2R9AUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9597:CNGA1
gene id: 9597:CNGA1
uniprot id: A0A2R8ZMB6
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
messages: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.

9597:SCAMP3
gene id: 9597:SCAMP3
uniprot id: A0A2R9A3I7
uniprot id: A0A2R9A4P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:FGF20
gene id: 9597:FGF20
uniprot id: A0A2R9AHG1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:TREH
gene id: 9597:TREH
uniprot id: A0A2R9C6C2
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9597:F2
gene id: 9597:F2
uniprot id: A0A2R9C6W7
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9597:DNMT1
gene id: 9597:DNMT1
uniprot id: A0A2R8ZXP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9597:PUF60
gene id: 9597:PUF60
uniprot id: A0A2R9A919
uniprot id: A0A2R9AA46
uniprot id: A0A2R9AEA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9597:KCNS3
gene id: 9597:KCNS3
uniprot id: A0A2R8Z5X2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:CLVS2
gene id: 9597:CLVS2
uniprot id: A0A2R9BFT0
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9597:C2AH2orf68
gene id: 9597:C2AH2orf68
uniprot id: A0A2R8ZS34
names: Similarity
messages: Belongs to the UPF0561 family.

9597:SGIP1
gene id: 9597:SGIP1
uniprot id: A0A2R9C7T5
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9597:RBP1
gene id: 9597:RBP1
uniprot id: A0A2R8ZX83
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:LOC100970998
gene id: 9597:LOC100970998
uniprot id: A0A2R8Z7P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9597:HSPA8
gene id: 9597:HSPA8
uniprot id: A0A2R9C3N8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9597:HOXB7
gene id: 9597:HOXB7
uniprot id: A0A2R8ZFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:TAF6
gene id: 9597:TAF6
uniprot id: A0A2R9BD84
uniprot id: A0A2R9BK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9597:PSMC4
gene id: 9597:PSMC4
uniprot id: A0A2R9AQT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9597:ZNF568
gene id: 9597:ZNF568
uniprot id: A0A2R9ACR5
names: Function
messages: May be involved in transcriptional regulation.

9597:PTCH1
gene id: 9597:PTCH1
uniprot id: A0A2R9C9L0
uniprot id: A0A2R9C9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9597:DNASE1L3
gene id: 9597:DNASE1L3
uniprot id: A0A2R9CDX2
names: Similarity
messages: Belongs to the DNase I family.

9597:POLM
gene id: 9597:POLM
uniprot id: A0A2R9BRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9597:SLC6A14
gene id: 9597:SLC6A14
uniprot id: A0A2R8ZY55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:MINDY3
gene id: 9597:MINDY3
uniprot id: A0A2R9CE46
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9597:CTLA4
gene id: 9597:CTLA4
uniprot id: A0A2R9C7H7
uniprot id: A0A2R9CI29
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9597:LOC100968749
gene id: 9597:LOC100968749
uniprot id: A0A2R9A3H5
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9597:ST3GAL3
gene id: 9597:ST3GAL3
uniprot id: A0A2R9C323
uniprot id: A0A2R9C3E6
uniprot id: A0A2R9C3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:CRABP1
gene id: 9597:CRABP1
uniprot id: A0A2R8ZL11
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

9597:LOC100978282
gene id: 9597:LOC100978282
uniprot id: A0A2R9AQM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative pheromone receptor.

9597:GCHFR
gene id: 9597:GCHFR
uniprot id: A0A2R9BAE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9597:OSBPL6
gene id: 9597:OSBPL6
uniprot id: A0A2R8ZQ83
uniprot id: A0A2R8ZTB4
uniprot id: A0A2R8ZTB9
names: Similarity
messages: Belongs to the OSBP family.

9597:FGD5
gene id: 9597:FGD5
uniprot id: A0A2R8ZVC3
names: Subcellular Location Annotation
messages: cytoskeleton

9597:CXXC5
gene id: 9597:CXXC5
uniprot id: A0A2R8ZN63
names: Subcellular Location Annotation
messages: Cytoplasm

9597:RAD21L1
gene id: 9597:RAD21L1
uniprot id: A0A2R8ZEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:C16H16orf71
gene id: 9597:C16H16orf71
uniprot id: A0A2R9C6N9
names: Function
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

9597:LOC100975318
gene id: 9597:LOC100975318
uniprot id: A0A2R9CMC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9597:NLK
gene id: 9597:NLK
uniprot id: A0A2R9AE67
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9597:NUP107
gene id: 9597:NUP107
uniprot id: A0A2R9AD58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9597:EIF4E2
gene id: 9597:EIF4E2
uniprot id: A0A2R9B0X3
uniprot id: A0A2R9B2B9
uniprot id: A0A2R9B4S9
uniprot id: A0A2R9B799
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9597:MED21
gene id: 9597:MED21
uniprot id: A0A2R9AF15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9597:JMJD1C
gene id: 9597:JMJD1C
uniprot id: A0A2R9CGF6
uniprot id: A0A2R9CJ42
names: Subcellular Location Annotation
messages: Nucleus

9597:MMS22L
gene id: 9597:MMS22L
uniprot id: A0A2R8ZT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9597:NDUFA11
gene id: 9597:NDUFA11
uniprot id: A0A2R8ZMW9
uniprot id: A0A2R8ZTU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:NCOA1
gene id: 9597:NCOA1
uniprot id: A0A2R9CAU3
uniprot id: A0A2R9CDJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9597:ANXA2
gene id: 9597:ANXA2
uniprot id: A0A2R9CNI1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9597:PHKG1
gene id: 9597:PHKG1
uniprot id: A0A2R9ASX0
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9597:FAM83D
gene id: 9597:FAM83D
uniprot id: A0A2R9BBD9
names: Similarity
messages: Belongs to the FAM83 family.

9597:NUDC
gene id: 9597:NUDC
uniprot id: A0A2R8Z5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9597:COPG1
gene id: 9597:COPG1
uniprot id: A0A2R8ZYG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9597:TRAF6
gene id: 9597:TRAF6
uniprot id: A0A2R9CI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9597:MOB3C
gene id: 9597:MOB3C
uniprot id: A0A2R9CFE6
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:LOC100972384
gene id: 9597:LOC100972384
uniprot id: A0A2R9C9M6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:SLC4A9
gene id: 9597:SLC4A9
uniprot id: A0A2R8ZFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9597:CPB1
gene id: 9597:CPB1
uniprot id: A0A2R9BJL6
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:LOC100979694
gene id: 9597:LOC100979694
uniprot id: A0A2R8ZJ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PPP1R16B
gene id: 9597:PPP1R16B
uniprot id: A0A2R8ZVF3
uniprot id: A0A2R8ZZW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:VPS29
gene id: 9597:VPS29
uniprot id: A0A2R9BLX8
uniprot id: A0A2R9BVZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9597:SERPINA11
gene id: 9597:SERPINA11
uniprot id: A0A2R9BAT4
names: Similarity
messages: Belongs to the serpin family.

9597:PDP2
gene id: 9597:PDP2
uniprot id: A0A2R8Z6Q8
names: Similarity
messages: Belongs to the PP2C family.

9597:DDO
gene id: 9597:DDO
uniprot id: A0A2R9B5I8
uniprot id: A0A2R9B716
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9597:HMGN1
gene id: 9597:HMGN1
uniprot id: A0A2R9AQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9597:TRAK1
gene id: 9597:TRAK1
uniprot id: A0A2R9A2T9
uniprot id: A0A2R9A7F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9597:FES
gene id: 9597:FES
uniprot id: A0A2R9B472
uniprot id: A0A2R9B5Q6
uniprot id: A0A2R9BB03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9597:BCHE
gene id: 9597:BCHE
uniprot id: A0A2R9BEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9597:FAM160A2
gene id: 9597:FAM160A2
uniprot id: A0A2R9AI96
names: Similarity
messages: Belongs to the FHIP family.

9597:CLDN11
gene id: 9597:CLDN11
uniprot id: A0A2R8ZNI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:ADGRG1
gene id: 9597:ADGRG1
uniprot id: A0A2R8ZWN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9597:IFNG
gene id: 9597:IFNG
uniprot id: A0A2R9CC85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9597:RBM15
gene id: 9597:RBM15
uniprot id: A0A2R9C994
names: Similarity
messages: Belongs to the RRM Spen family.

9597:SLC1A7
gene id: 9597:SLC1A7
uniprot id: A0A2R9BDY0
uniprot id: A0A2R9BL66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FMNL3
gene id: 9597:FMNL3
uniprot id: A0A2R9A721
uniprot id: A0A2R9ABS3
names: Similarity
messages: Belongs to the formin homology family.

9597:ENO1
gene id: 9597:ENO1
uniprot id: A0A2R8Z7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9597:PADI4
gene id: 9597:PADI4
uniprot id: A0A2R9AGC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9597:EPB41
gene id: 9597:EPB41
uniprot id: A0A2R9BLM6
uniprot id: A0A2R9BMC0
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9597:RBKS
gene id: 9597:RBKS
uniprot id: A0A2R9AXG3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9597:FGD1
gene id: 9597:FGD1
uniprot id: A0A2R9CM84
names: Subcellular Location Annotation
messages: cytoskeleton

9597:APLP1
gene id: 9597:APLP1
uniprot id: A0A2R9AFK0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CDX4
gene id: 9597:CDX4
uniprot id: A0A2R9BDJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9597:GLI1
gene id: 9597:GLI1
uniprot id: A0A2R9CQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9597:CMC2
gene id: 9597:CMC2
uniprot id: A0A2R9AJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9597:TRABD2A
gene id: 9597:TRABD2A
uniprot id: A0A2R9BW86
uniprot id: A0A2R9BW90
uniprot id: A0A2R9C5V8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9597:CDH4
gene id: 9597:CDH4
uniprot id: A0A2R9AIS2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:ANK1
gene id: 9597:ANK1
uniprot id: A0A2R9AEU3
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:WRN
gene id: 9597:WRN
uniprot id: A0A2R9BLV2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9597:FTSJ1
gene id: 9597:FTSJ1
uniprot id: A0A2R9A0A8
uniprot id: A0A2R9A1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9597:SERINC1
gene id: 9597:SERINC1
uniprot id: A0A2R9C3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9597:DEFB114
gene id: 9597:DEFB114
uniprot id: A0A2R9ABV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:AFG3L2
gene id: 9597:AFG3L2
uniprot id: A0A2R8Z921
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9597:DPYS
gene id: 9597:DPYS
uniprot id: A0A2R9CME1
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9597:MINAR2
gene id: 9597:MINAR2
uniprot id: A0A2R9C4E7
names: Similarity
messages: Belongs to the MINAR family.

9597:PPP5C
gene id: 9597:PPP5C
uniprot id: A0A2R9BNS1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9597:ZPR1
gene id: 9597:ZPR1
uniprot id: A0A2R9BCU3
names: Similarity
messages: Belongs to the ZPR1 family.

9597:BCKDK
gene id: 9597:BCKDK
uniprot id: A0A2R9A9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9597:CRYGN
gene id: 9597:CRYGN
uniprot id: A0A2R8ZMZ8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:PYM1
gene id: 9597:PYM1
uniprot id: A0A2R9CJC7
uniprot id: A0A2R9CJF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9597:DCSTAMP
gene id: 9597:DCSTAMP
uniprot id: A0A2R9CK08
names: Subcellular Location Annotation
messages: Membrane

9597:OR7D4
gene id: 9597:OR7D4
uniprot id: D1MFA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:INO80D
gene id: 9597:INO80D
uniprot id: A0A2R8ZGA6
names: Subcellular Location Annotation
messages: Nucleus

9597:ORMDL1
gene id: 9597:ORMDL1
uniprot id: A0A2R9C6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9597:ST7L
gene id: 9597:ST7L
uniprot id: A0A2R9BHE9
uniprot id: A0A2R9BHF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9597:EXOC2
gene id: 9597:EXOC2
uniprot id: A0A2R9A9J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9597:SPRR3
gene id: 9597:SPRR3
uniprot id: A0A2R8ZLP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9597:ASL
gene id: 9597:ASL
uniprot id: A0A2R9BWW6
uniprot id: A0A2R9BWX4
uniprot id: A0A2R9BXK2
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9597:ZNF235
gene id: 9597:ZNF235
uniprot id: A0A2R9AI52
names: Function
messages: May be involved in transcriptional regulation.

9597:MAPK9
gene id: 9597:MAPK9
uniprot id: A0A2R9BKH2
uniprot id: A0A2R9BL65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9597:RAD21
gene id: 9597:RAD21
uniprot id: A0A2R8ZFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:RNF170
gene id: 9597:RNF170
uniprot id: A0A2R8ZMV7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ASB10
gene id: 9597:ASB10
uniprot id: A0A2R9C4I6
uniprot id: A0A2R9C4X4
uniprot id: A0A2R9C7H8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:FAM168A
gene id: 9597:FAM168A
uniprot id: A0A2R9CEJ3
names: Similarity
messages: Belongs to the FAM168 family.

9597:SCML4
gene id: 9597:SCML4
uniprot id: A0A2R8ZIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9597:IZUMO2
gene id: 9597:IZUMO2
uniprot id: A0A2R9BH87
names: Similarity
messages: Belongs to the Izumo family.

9597:NKX2-8
gene id: 9597:NKX2-8
uniprot id: A0A2R9BXM0
names: Subcellular Location Annotation
messages: Nucleus

9597:MTMR3
gene id: 9597:MTMR3
uniprot id: A0A2R9BKZ8
uniprot id: A0A2R9BR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9597:ORC3
gene id: 9597:ORC3
uniprot id: A0A2R9BMI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9597:ARPC1A
gene id: 9597:ARPC1A
uniprot id: A0A2R9AR18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9597:ENDOG
gene id: 9597:ENDOG
uniprot id: A0A2R9C4H9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9597:SLC25A11
gene id: 9597:SLC25A11
uniprot id: A0A2R9C729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:GFRAL
gene id: 9597:GFRAL
uniprot id: A0A2R9BKW6
names: Similarity
messages: Belongs to the GDNFR family.

9597:FRRS1
gene id: 9597:FRRS1
uniprot id: A0A2R9C039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9597:RPL7L1
gene id: 9597:RPL7L1
uniprot id: A0A2R8ZYZ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9597:EDA2R
gene id: 9597:EDA2R
uniprot id: A0A2R8ZCJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RPLP0
gene id: 9597:RPLP0
uniprot id: A0A2R9AAE7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9597:VPS13A
gene id: 9597:VPS13A
uniprot id: A0A2R8Z9J5
uniprot id: A0A2R8ZDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9597:GUCA2B
gene id: 9597:GUCA2B
uniprot id: A0A2R9BDN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9597:PRND
gene id: 9597:PRND
uniprot id: A0A2R8ZAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9597:TBPL1
gene id: 9597:TBPL1
uniprot id: A0A2R8ZHH2
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9597:GSTM3
gene id: 9597:GSTM3
uniprot id: A0A2R8ZY73
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9597:CUL2
gene id: 9597:CUL2
uniprot id: A0A2R9BAC0
uniprot id: A0A2R9BCL7
names: Similarity
messages: Belongs to the cullin family.

9597:LOC103785360
gene id: 9597:LOC103785360
uniprot id: A0A2R8ZKB9
names: Similarity
messages: Belongs to the NGF-beta family.

9597:RPL35
gene id: 9597:RPL35
uniprot id: A0A2R8ZRY3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9597:NIPAL3
gene id: 9597:NIPAL3
uniprot id: A0A2R9AXZ0
uniprot id: A0A2R9B3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9597:TAF11
gene id: 9597:TAF11
uniprot id: A0A2R9C8S6
uniprot id: A0A2R9CGM7
names: Similarity
messages: Belongs to the TAF11 family.

9597:CKAP2
gene id: 9597:CKAP2
uniprot id: A0A2R9AZI9
names: Similarity
messages: Belongs to the CKAP2 family.

9597:ZNF460
gene id: 9597:ZNF460
uniprot id: A0A2R9C8I3
names: Function
messages: May be involved in transcriptional regulation.

9597:ZFP90
gene id: 9597:ZFP90
uniprot id: A0A2R9B4I6
uniprot id: A0A2R9B6R8
names: Function
messages: May be involved in transcriptional regulation.

9597:MS4A7
gene id: 9597:MS4A7
uniprot id: A0A2R9CN30
names: Similarity
messages: Belongs to the MS4A family.

9597:APAF1
gene id: 9597:APAF1
uniprot id: A0A2R9AIY1
uniprot id: A0A2R9AJS4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9597:SLC25A46
gene id: 9597:SLC25A46
uniprot id: A0A2R9CDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:CD14
gene id: 9597:CD14
uniprot id: B3Y6B4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9597:IL24
gene id: 9597:IL24
uniprot id: A0A2R9BHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9597:MTFR1
gene id: 9597:MTFR1
uniprot id: A0A2R9ACU4
uniprot id: A0A2R9AHU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9597:ST6GAL2
gene id: 9597:ST6GAL2
uniprot id: A0A2R9B816
uniprot id: A0A2R9BBT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9597:LOC100982169
gene id: 9597:LOC100982169
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:SDHAF3
gene id: 9597:SDHAF3
uniprot id: A0A2R9BID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9597:B4GALT3
gene id: 9597:B4GALT3
uniprot id: A0A2R9AR93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:ACTR5
gene id: 9597:ACTR5
uniprot id: A0A2R8Z991
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

9597:SLC25A31
gene id: 9597:SLC25A31
uniprot id: A0A2R9A6Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9597:RNF8
gene id: 9597:RNF8
uniprot id: A0A2R9AN67
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9597:ETV2
gene id: 9597:ETV2
uniprot id: A0A2R9BNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:GATA2
gene id: 9597:GATA2
uniprot id: A0A2R8ZVR6
names: Subcellular Location Annotation
messages: Nucleus

9597:TRARG1
gene id: 9597:TRARG1
uniprot id: A0A2R9ACJ5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:FZD6
gene id: 9597:FZD6
uniprot id: A0A2R9B4K7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PARP4
gene id: 9597:PARP4
uniprot id: A0A2R8ZM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9597:CHN2
gene id: 9597:CHN2
uniprot id: A0A2R9AIP2
names: Function
messages: GTPase-activating protein for p21-rac.

9597:GFOD1
gene id: 9597:GFOD1
uniprot id: A0A2R9ABE3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:BECN2
gene id: 9597:BECN2
uniprot id: A0A2R8ZFZ4
names: Similarity
messages: Belongs to the beclin family.

9597:NR2C2
gene id: 9597:NR2C2
uniprot id: A0A2R8ZNX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:LCAT
gene id: 9597:LCAT
uniprot id: A0A2R9BD07
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:GLIPR1
gene id: 9597:GLIPR1
uniprot id: A0A2R9BRE0
names: Similarity
messages: Belongs to the CRISP family.

9597:MARVELD2
gene id: 9597:MARVELD2
uniprot id: A0A2R9AHD4
uniprot id: A0A2R9APH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:PARP8
gene id: 9597:PARP8
uniprot id: A0A2R9A9J6
uniprot id: A0A2R9AF07
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:CCL18
gene id: 9597:CCL18
uniprot id: A0A2R9BML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:GRM6
gene id: 9597:GRM6
uniprot id: A0A2R9BEN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9597:CORO1B
gene id: 9597:CORO1B
uniprot id: A0A2R9A938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.
messages: stress fiber

9597:RNF2
gene id: 9597:RNF2
uniprot id: A0A2R9A0Q0
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9597:TAS2R5
gene id: 9597:TAS2R5
uniprot id: Q646D5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:PLPP3
gene id: 9597:PLPP3
uniprot id: A0A2R9CLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:DDIT3
gene id: 9597:DDIT3
uniprot id: A0A2R9AYQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9597:ZNF254
gene id: 9597:ZNF254
uniprot id: A0A2R9A9H9
names: Function
messages: May be involved in transcriptional regulation.

9597:TRAF5
gene id: 9597:TRAF5
uniprot id: A0A2R9AKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9597:C1D
gene id: 9597:C1D
uniprot id: A0A2R9BSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9597:NME7
gene id: 9597:NME7
uniprot id: A0A2R9BXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9597:RPL39L
gene id: 9597:RPL39L
uniprot id: A0A2R8ZAE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9597:SLC35E2B
gene id: 9597:SLC35E2B
uniprot id: A0A2R9BW13
uniprot id: A0A2R9BWQ5
names: Subcellular Location Annotation
messages: Membrane

9597:ZRANB1
gene id: 9597:ZRANB1
uniprot id: A0A2R9BAV0
names: Similarity
messages: Belongs to the peptidase C64 family.

9597:LOC100985075
gene id: 9597:LOC100985075
uniprot id: Q646E3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:SEC23A
gene id: 9597:SEC23A
uniprot id: A0A2R8ZZK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:HOMEZ
gene id: 9597:HOMEZ
uniprot id: A0A2R9BK87
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC103784642
gene id: 9597:LOC103784642
uniprot id: A0A2R9AQR0
names: Function
messages: May be involved in transcriptional regulation.

9597:EPC1
gene id: 9597:EPC1
uniprot id: A0A2R9AP37
uniprot id: A0A2R9ASZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9597:YIPF3
gene id: 9597:YIPF3
uniprot id: A0A2R8ZLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9597:LOC100986481
gene id: 9597:LOC100986481
uniprot id: G4XXM0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9597:DHODH
gene id: 9597:DHODH
uniprot id: A0A2R9BWW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9597:FAM3A
gene id: 9597:FAM3A
uniprot id: A0A2R9A0F8
uniprot id: A0A2R9A607
uniprot id: A0A2R9A613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:GAPDH
gene id: 9597:GAPDH
uniprot id: A0A2R9BWP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9597:SPO11
gene id: 9597:SPO11
uniprot id: A0A2R9B8U8
uniprot id: A0A2R9BGA0
names: Similarity
messages: Belongs to the TOP6A family.

9597:CHST6
gene id: 9597:CHST6
uniprot id: A0A2R8Z788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9597:CRY2
gene id: 9597:CRY2
uniprot id: A0A2R9AVA7
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9597:CLPP
gene id: 9597:CLPP
uniprot id: A0A2R9CDX0
names: Similarity
messages: Belongs to the peptidase S14 family.

9597:ASPH
gene id: 9597:ASPH
uniprot id: A0A2R9BAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9597:GNA15
gene id: 9597:GNA15
uniprot id: A0A2R9C5A3
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9597:RTN3
gene id: 9597:RTN3
uniprot id: A0A2R9AEJ4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TSPO2
gene id: 9597:TSPO2
uniprot id: A0A2R9C919
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9597:TES
gene id: 9597:TES
uniprot id: A0A2R9B209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

9597:HOXC12
gene id: 9597:HOXC12
uniprot id: A0A2R9AD08
names: Subcellular Location Annotation
messages: Nucleus

9597:PIGV
gene id: 9597:PIGV
uniprot id: A0A2R9AWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9597:NDUFS8
gene id: 9597:NDUFS8
uniprot id: A0A2R9BSV7
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9597:TMCC3
gene id: 9597:TMCC3
uniprot id: A0A2R9CT21
names: Similarity
messages: Belongs to the TEX28 family.

9597:ESX1
gene id: 9597:ESX1
uniprot id: A0A2R8ZPQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:NR4A1
gene id: 9597:NR4A1
uniprot id: A0A2R9B4U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9597:POP5
gene id: 9597:POP5
uniprot id: A0A2R9CJZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9597:PIGB
gene id: 9597:PIGB
uniprot id: A0A2R9CHF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9597:AURKC
gene id: 9597:AURKC
uniprot id: A0A2R9C9K6
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9597:LOC100982199
gene id: 9597:LOC100982199
uniprot id: A0A2R8ZN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:SH3RF2
gene id: 9597:SH3RF2
uniprot id: A0A2R9CMR3
names: Similarity
messages: Belongs to the SH3RF family.

9597:LYPLA1
gene id: 9597:LYPLA1
uniprot id: A0A2R9BL27
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9597:UCP3
gene id: 9597:UCP3
uniprot id: A0A2R9CJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:TFAP2C
gene id: 9597:TFAP2C
uniprot id: A0A2R9AQD2
names: Similarity
messages: Belongs to the AP-2 family.

9597:P2RY1
gene id: 9597:P2RY1
uniprot id: A0A2R8ZUR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:KBTBD8
gene id: 9597:KBTBD8
uniprot id: A0A2R9C7L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9597:NKIRAS1
gene id: 9597:NKIRAS1
uniprot id: A0A2R9B1Q5
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9597:CCND3
gene id: 9597:CCND3
uniprot id: A0A2R9A185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9597:CAVIN3
gene id: 9597:CAVIN3
uniprot id: A0A2R9CF66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9597:CAMK2N2
gene id: 9597:CAMK2N2
uniprot id: A0A2R8ZH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9597:PLEKHA8
gene id: 9597:PLEKHA8
uniprot id: A0A2R9BJM9
uniprot id: A0A2R9BMB7
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9597:SLC7A10
gene id: 9597:SLC7A10
uniprot id: A0A2R9A9J3
names: Subcellular Location Annotation
messages: Membrane

9597:CDK20
gene id: 9597:CDK20
uniprot id: A0A2R9BAB7
uniprot id: A0A2R9BBN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:DCTN2
gene id: 9597:DCTN2
uniprot id: A0A2R8ZF37
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9597:FGF16
gene id: 9597:FGF16
uniprot id: A0A2R9AZR1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:LOC100968718
gene id: 9597:LOC100968718
uniprot id: A0A2R8Z5M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9597:IFNA6
gene id: 9597:IFNA6
uniprot id: A0A2R8ZAA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:ADGRB3
gene id: 9597:ADGRB3
uniprot id: A0A2R9BJC0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:RNF121
gene id: 9597:RNF121
uniprot id: A0A2R9AR76
uniprot id: A0A2R9ARS8
names: Subcellular Location Annotation
messages: Membrane

9597:DRC1
gene id: 9597:DRC1
uniprot id: A0A2R9A9Z6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

9597:CXCR1
gene id: 9597:CXCR1
uniprot id: A0A2R8ZQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:MAEL
gene id: 9597:MAEL
uniprot id: A0A2R9CAB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9597:LHX2
gene id: 9597:LHX2
uniprot id: A0A2R9AZ03
names: Subcellular Location Annotation
messages: Nucleus

9597:SFMBT2
gene id: 9597:SFMBT2
uniprot id: A0A2R9BTG2
names: Subcellular Location Annotation
messages: Nucleus

9597:LGI4
gene id: 9597:LGI4
uniprot id: A0A2R9AUI5
names: Subcellular Location Annotation
messages: Secreted

9597:RHCG
gene id: 9597:RHCG
uniprot id: A0A2R9C1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9597:PTK2
gene id: 9597:PTK2
uniprot id: A0A2R9CGE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9597:GRP
gene id: 9597:GRP
uniprot id: A0A2R9CG81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

9597:PTPN3
gene id: 9597:PTPN3
uniprot id: A0A2R9CS47
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

9597:LOC100972491
gene id: 9597:LOC100972491
uniprot id: A0A2R8ZCA5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:NNAT
gene id: 9597:NNAT
uniprot id: A0A2R9C8E9
uniprot id: A0A2R9C8R6
names: Similarity
messages: Belongs to the neuronatin family.

9597:NOL11
gene id: 9597:NOL11
uniprot id: A0A2R9AW31
names: Subcellular Location Annotation
messages: nucleolus

9597:CDC25A
gene id: 9597:CDC25A
uniprot id: A0A2R9B0S6
uniprot id: A0A2R9B4N0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9597:APCS
gene id: 9597:APCS
uniprot id: A0A2R9C9Y7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9597:ZNF789
gene id: 9597:ZNF789
uniprot id: A0A2R9C0B7
uniprot id: A0A2R9C0W9
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100987138
gene id: 9597:LOC100987138
uniprot id: A0A2R9CCW2
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:PTK2B
gene id: 9597:PTK2B
uniprot id: A0A2R9BL74
uniprot id: A0A2R9BP01
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9597:IL23A
gene id: 9597:IL23A
uniprot id: A0A2R9CIV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9597:HPGD
gene id: 9597:HPGD
uniprot id: A0A2R9BY99
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:ARHGDIA
gene id: 9597:ARHGDIA
uniprot id: A0A2R9BA66
names: Similarity
messages: Belongs to the Rho GDI family.

9597:ACSS3
gene id: 9597:ACSS3
uniprot id: A0A2R9C396
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:AP4S1
gene id: 9597:AP4S1
uniprot id: A0A2R9C6K9
uniprot id: A0A2R9C6L8
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9597:GNG4
gene id: 9597:GNG4
uniprot id: A0A2R9ATT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:LCE1F
gene id: 9597:LCE1F
uniprot id: A0A2R8Z6G1
names: Similarity
messages: Belongs to the LCE family.

9597:FMO3
gene id: 9597:FMO3
uniprot id: A0A2R9B212
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9597:UNC119B
gene id: 9597:UNC119B
uniprot id: A0A2R9CPV0
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9597:CENPQ
gene id: 9597:CENPQ
uniprot id: A0A2R9BPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9597:LRRFIP1
gene id: 9597:LRRFIP1
uniprot id: A0A2R8ZX94
names: Similarity
messages: Belongs to the LRRFIP family.

9597:CSNK1A1L
gene id: 9597:CSNK1A1L
uniprot id: A0A2R8ZLE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:LIPF
gene id: 9597:LIPF
uniprot id: A0A2R9A4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9597:KLC4
gene id: 9597:KLC4
uniprot id: A0A2R9AQJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9597:NEU2
gene id: 9597:NEU2
uniprot id: A0A2R9BJ98
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9597:IGF2BP1
gene id: 9597:IGF2BP1
uniprot id: A0A2R9C8U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule
messages: filopodium
messages: lamellipodium

9597:SETDB2
gene id: 9597:SETDB2
uniprot id: A0A2R9BX57
uniprot id: A0A2R9BZX0
names: Subcellular Location Annotation
messages: Chromosome

9597:RPLP2
gene id: 9597:RPLP2
uniprot id: A0A2R8ZWV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9597:DYNC1I1
gene id: 9597:DYNC1I1
uniprot id: A0A2R9CKL4
uniprot id: A0A2R9CRF2
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9597:GNAT1
gene id: 9597:GNAT1
uniprot id: A0A2R9AZM2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:LOC100990437
gene id: 9597:LOC100990437
uniprot id: A0A2R9BIH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9597:TSPO
gene id: 9597:TSPO
uniprot id: A0A2R8ZE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane
messages: Mitochondrion membrane

9597:RPL26
gene id: 9597:RPL26
uniprot id: A0A2R9CF39
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9597:C12H12orf65
gene id: 9597:C12H12orf65
uniprot id: A0A2R9A6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9597:ADGRG3
gene id: 9597:ADGRG3
uniprot id: A0A2R9BJ79
names: Subcellular Location Annotation
messages: Membrane

9597:PRKCE
gene id: 9597:PRKCE
uniprot id: A0A2R9AUU7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9597:TRPC3
gene id: 9597:TRPC3
uniprot id: A0A2R9AZ30
names: Subcellular Location Annotation
messages: Membrane

9597:LYPD6B
gene id: 9597:LYPD6B
uniprot id: A0A2R9BWK6
uniprot id: A0A2R9BZZ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:NFS1
gene id: 9597:NFS1
uniprot id: A0A2R9BYF7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9597:SEC13
gene id: 9597:SEC13
uniprot id: A0A2R9CFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9597:ATP10B
gene id: 9597:ATP10B
uniprot id: A0A2R9C7A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:PTPRZ1
gene id: 9597:PTPRZ1
uniprot id: A0A2R9CDB5
uniprot id: A0A2R9CFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9597:AFF4
gene id: 9597:AFF4
uniprot id: A0A2R9CJU9
names: Similarity
messages: Belongs to the AF4 family.

9597:LCK
gene id: 9597:LCK
uniprot id: A0A2R9AKH9
uniprot id: A0A2R9AKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9597:OXSR1
gene id: 9597:OXSR1
uniprot id: A0A2R9A1K9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9597:CXCL5
gene id: 9597:CXCL5
uniprot id: A0A2R9B6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:ALX1
gene id: 9597:ALX1
uniprot id: A0A2R9B0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:PEPD
gene id: 9597:PEPD
uniprot id: A0A2R8ZZT3
names: Similarity
messages: Belongs to the peptidase M24B family.

9597:ZNF621
gene id: 9597:ZNF621
uniprot id: A0A2R9CQ47
names: Function
messages: May be involved in transcriptional regulation.

9597:TMEM63A
gene id: 9597:TMEM63A
uniprot id: A0A2R9B2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9597:MYO1D
gene id: 9597:MYO1D
uniprot id: A0A2R9BD01
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:RAF1
gene id: 9597:RAF1
uniprot id: A0A2R9B7H5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9597:GUK1
gene id: 9597:GUK1
uniprot id: A0A2R9AGD7
names: Similarity
messages: Belongs to the guanylate kinase family.

9597:SLC6A16
gene id: 9597:SLC6A16
uniprot id: A0A2R9BLK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:ANAPC13
gene id: 9597:ANAPC13
uniprot id: A0A2R9ACC0
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9597:TAS2R60
gene id: 9597:TAS2R60
uniprot id: Q646D0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:ALDH3A1
gene id: 9597:ALDH3A1
uniprot id: A0A2R9CHQ4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:SYNE1
gene id: 9597:SYNE1
uniprot id: A0A2R8ZXI5
names: Similarity
messages: Belongs to the nesprin family.

9597:SLC9A4
gene id: 9597:SLC9A4
uniprot id: A0A2R9B217
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9597:PUS3
gene id: 9597:PUS3
uniprot id: A0A2R8ZSK3
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9597:ILF3
gene id: 9597:ILF3
uniprot id: A0A2R9C1L7
uniprot id: A0A2R9C1N5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:ADAMTS5
gene id: 9597:ADAMTS5
uniprot id: A0A2R9BJM3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:ARRDC4
gene id: 9597:ARRDC4
uniprot id: A0A2R9BXP8
names: Similarity
messages: Belongs to the arrestin family.

9597:LOC100986914
gene id: 9597:LOC100986914
uniprot id: A0A2R8ZJK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9597:GLS2
gene id: 9597:GLS2
uniprot id: A0A2R8ZZ76
names: Similarity
messages: Belongs to the glutaminase family.

9597:ZNF280C
gene id: 9597:ZNF280C
uniprot id: A0A2R8ZVK6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9597:RUNX3
gene id: 9597:RUNX3
uniprot id: A0A2R9B517
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9597:LRP10
gene id: 9597:LRP10
uniprot id: A0A2R9AA34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:KLRK1
gene id: 9597:KLRK1
uniprot id: A0A2R8ZBC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:HIGD1C
gene id: 9597:HIGD1C
uniprot id: A0A2R9B916
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:MTHFD1L
gene id: 9597:MTHFD1L
uniprot id: A0A2R9B0N7
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9597:C16H16orf70
gene id: 9597:C16H16orf70
uniprot id: A0A2R9BNC5
names: Similarity
messages: Belongs to the PHAF1 family.

9597:TRIM54
gene id: 9597:TRIM54
uniprot id: A0A2R9BCG1
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9597:LOC100967245
gene id: 9597:LOC100967245
uniprot id: A0A2R9AY08
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9597:AGO1
gene id: 9597:AGO1
uniprot id: A0A2R9B1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9597:NDUFB2
gene id: 9597:NDUFB2
uniprot id: A0A2R9BWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:ASIC3
gene id: 9597:ASIC3
uniprot id: A0A2R9BJ81
uniprot id: A0A2R9BS54
names: Subcellular Location Annotation
messages: Membrane

9597:PPIP5K2
gene id: 9597:PPIP5K2
uniprot id: A0A2R8ZTV3
uniprot id: A0A2R8ZYH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9597:PGAP2
gene id: 9597:PGAP2
uniprot id: A0A2R9CCL3
uniprot id: A0A2R9CF12
uniprot id: A0A2R9CF49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9597:TNFRSF10A
gene id: 9597:TNFRSF10A
uniprot id: A0A2R9C3Q3
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9597:CD200
gene id: 9597:CD200
uniprot id: A0A2R9A9M0
uniprot id: A0A2R9ADU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:LOC100971024
gene id: 9597:LOC100971024
uniprot id: A0A2R9ASA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9597:GNRHR
gene id: 9597:GNRHR
uniprot id: A0A2R9C7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:DEUP1
gene id: 9597:DEUP1
uniprot id: A0A2R9A7E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9597:RBBP8
gene id: 9597:RBBP8
uniprot id: A0A2R8ZPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9597:DMTF1
gene id: 9597:DMTF1
uniprot id: A0A2R9B7A4
names: Subcellular Location Annotation
messages: Nucleus

9597:KRT8
gene id: 9597:KRT8
uniprot id: A0A2R9A6T6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:GPR34
gene id: 9597:GPR34
uniprot id: Q3SAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Orphan receptor.

9597:STK38
gene id: 9597:STK38
uniprot id: A0A2R9BT32
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:PMP2
gene id: 9597:PMP2
uniprot id: A0A2R9A080
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9597:GPBP1
gene id: 9597:GPBP1
uniprot id: A0A2R8ZVE5
uniprot id: A0A2R9A114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9597:DDC
gene id: 9597:DDC
uniprot id: A0A2R9A9P2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:GAD1
gene id: 9597:GAD1
uniprot id: A0A2R9B9E1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:CLDND2
gene id: 9597:CLDND2
uniprot id: A0A2R9AAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9597:CCL15
gene id: 9597:CCL15
uniprot id: A0A2R9B897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:GRIA2
gene id: 9597:GRIA2
uniprot id: A0A2R9BL79
uniprot id: A0A2R9BPR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:ANXA11
gene id: 9597:ANXA11
uniprot id: A0A2R9B7V6
uniprot id: A0A2R9B9B5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9597:PRRC1
gene id: 9597:PRRC1
uniprot id: A0A2R8ZQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9597:KIF24
gene id: 9597:KIF24
uniprot id: A0A2R9A000
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:BMP2
gene id: 9597:BMP2
uniprot id: A0A2R9ABN7
names: Similarity
messages: Belongs to the TGF-beta family.

9597:TBCE
gene id: 9597:TBCE
uniprot id: A0A2R9A128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9597:ZFP92
gene id: 9597:ZFP92
uniprot id: A0A2R9A217
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC25A19
gene id: 9597:SLC25A19
uniprot id: A0A2R9BB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:TMEM14B
gene id: 9597:TMEM14B
uniprot id: A0A2R9AB04
names: Similarity
messages: Belongs to the TMEM14 family.

9597:PRKAR2A
gene id: 9597:PRKAR2A
uniprot id: A0A2R9AKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9597:LOC100972888
gene id: 9597:LOC100972888
uniprot id: A0A2R9AY07
names: Similarity
messages: Belongs to the peptidase M16 family.

9597:LOC100988969
gene id: 9597:LOC100988969
uniprot id: A0A2R9A967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9597:CRYZ
gene id: 9597:CRYZ
uniprot id: A0A2R9CDZ6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9597:PRPF4
gene id: 9597:PRPF4
uniprot id: A0A2R9CB33
names: Subcellular Location Annotation
messages: Nucleus speckle

9597:TAC4
gene id: 9597:TAC4
uniprot id: A0A2R9A569
names: Similarity
messages: Belongs to the tachykinin family.

9597:ZNF8
gene id: 9597:ZNF8
uniprot id: A0A2R9A750
names: Function
messages: May be involved in transcriptional regulation.

9597:TMED4
gene id: 9597:TMED4
uniprot id: A0A2R9B5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100990999
gene id: 9597:LOC100990999
uniprot id: A0A2R8ZKE4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LUM
gene id: 9597:LUM
uniprot id: A0A2R8ZXH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9597:PRDM10
gene id: 9597:PRDM10
uniprot id: A0A2R9CFG7
uniprot id: A0A2R9CFJ6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:PUS10
gene id: 9597:PUS10
uniprot id: A0A2R8ZQ34
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9597:MEF2A
gene id: 9597:MEF2A
uniprot id: A0A2R9B3E7
uniprot id: A0A2R9B3G6
uniprot id: A0A2R9BA52
names: Subcellular Location Annotation
messages: Nucleus

9597:FOLR1
gene id: 9597:FOLR1
uniprot id: A0A2R9ABR9
names: Similarity
messages: Belongs to the folate receptor family.

9597:DGAT2
gene id: 9597:DGAT2
uniprot id: A0A2R8ZFN0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:HABP2
gene id: 9597:HABP2
uniprot id: A0A2R9AIP9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:SEMA3B
gene id: 9597:SEMA3B
uniprot id: A0A2R9CEH4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PRDM1
gene id: 9597:PRDM1
uniprot id: A0A2R8ZUJ0
uniprot id: A0A2R8ZUJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9597:SLC7A3
gene id: 9597:SLC7A3
uniprot id: A0A2R8ZBV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9597:FLAD1
gene id: 9597:FLAD1
uniprot id: A0A2R8ZFY8
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9597:TATDN2
gene id: 9597:TATDN2
uniprot id: A0A2R9A5S1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9597:LOC100986643
gene id: 9597:LOC100986643
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:NIF3L1
gene id: 9597:NIF3L1
uniprot id: A0A2R9CLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9597:MSRB3
gene id: 9597:MSRB3
uniprot id: A0A2R9B061
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9597:SRP9
gene id: 9597:SRP9
uniprot id: A0A2R9CDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9597:AMHR2
gene id: 9597:AMHR2
uniprot id: A0A2R8ZS02
uniprot id: A0A2R8ZS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9597:SEPTIN4
gene id: 9597:SEPTIN4
uniprot id: A0A2R8ZYM4
uniprot id: A0A2R9A2N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:RPS27A
gene id: 9597:RPS27A
uniprot id: A0A2R9B0K9
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9597:CALHM1
gene id: 9597:CALHM1
uniprot id: A0A2R9BIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:RTCA
gene id: 9597:RTCA
uniprot id: A0A2R9B4J6
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9597:CLK2
gene id: 9597:CLK2
uniprot id: A0A2R9CJL9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:HMBOX1
gene id: 9597:HMBOX1
uniprot id: A0A2R8ZTM2
uniprot id: A0A2R8ZWC2
names: Subcellular Location Annotation
messages: Nucleus

9597:NDRG4
gene id: 9597:NDRG4
uniprot id: A0A2R9BG45
uniprot id: A0A2R9BG55
uniprot id: A0A2R9BH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9597:BSX
gene id: 9597:BSX
uniprot id: A0A2R9C627
names: Subcellular Location Annotation
messages: Nucleus

9597:GABARAP
gene id: 9597:GABARAP
uniprot id: A0A2R9AE68
names: Similarity
messages: Belongs to the ATG8 family.

9597:PIK3R3
gene id: 9597:PIK3R3
uniprot id: A0A2R8ZHQ7
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9597:SPP1
gene id: 9597:SPP1
uniprot id: A0A2R9BYD7
uniprot id: A0A2R9BYZ3
uniprot id: A0A2R9C8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9597:COQ7
gene id: 9597:COQ7
uniprot id: A0A2R9BAP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9597:BAAT
gene id: 9597:BAAT
uniprot id: A0A2R9BMP0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9597:LOC100974607
gene id: 9597:LOC100974607
uniprot id: A0A2R8ZI48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RRM1
gene id: 9597:RRM1
uniprot id: A0A2R9BPQ4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9597:BLK
gene id: 9597:BLK
uniprot id: A0A2R8ZDG4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:PDCD11
gene id: 9597:PDCD11
uniprot id: A0A2R8ZTQ6
names: Subcellular Location Annotation
messages: nucleolus

9597:TCTN3
gene id: 9597:TCTN3
uniprot id: A0A2R9CK10
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9597:DHX58
gene id: 9597:DHX58
uniprot id: A0A2R9AG97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9597:ELF3
gene id: 9597:ELF3
uniprot id: A0A2R9B6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:ITGA7
gene id: 9597:ITGA7
uniprot id: A0A2R9B961
uniprot id: A0A2R9B992
uniprot id: A0A2R9B996
uniprot id: A0A2R9BAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:TALDO1
gene id: 9597:TALDO1
uniprot id: A0A2R9ARX4
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9597:MED29
gene id: 9597:MED29
uniprot id: A0A2R9BE52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9597:NR5A2
gene id: 9597:NR5A2
uniprot id: A0A2R9BR60
uniprot id: A0A2R9BTY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9597:LOC100974537
gene id: 9597:LOC100974537
uniprot id: A0A2R8ZA82
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SLC5A1
gene id: 9597:SLC5A1
uniprot id: A0A2R9C7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9597:DCN
gene id: 9597:DCN
uniprot id: A0A2R9BU23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9597:GADD45B
gene id: 9597:GADD45B
uniprot id: A0A2R9CMK8
names: Similarity
messages: Belongs to the GADD45 family.

9597:VPS13D
gene id: 9597:VPS13D
uniprot id: A0A2R9AUX0
uniprot id: A0A2R9AV95
names: Similarity
messages: Belongs to the VPS13 family.

9597:SATB2
gene id: 9597:SATB2
uniprot id: A0A2R9CTC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9597:ADAMTS9
gene id: 9597:ADAMTS9
uniprot id: A0A2R8ZXK3
uniprot id: A0A2R8ZXK9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:KIF13A
gene id: 9597:KIF13A
uniprot id: A0A2R8ZDK8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:RAB29
gene id: 9597:RAB29
uniprot id: A0A2R8ZEE0
uniprot id: A0A2R8ZEE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9597:SEC22A
gene id: 9597:SEC22A
uniprot id: A0A2R9AA87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9597:SCML2
gene id: 9597:SCML2
uniprot id: A0A2R9BX05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9597:PPA1
gene id: 9597:PPA1
uniprot id: A0A2R9AJJ7
names: Similarity
messages: Belongs to the PPase family.

9597:QTRT1
gene id: 9597:QTRT1
uniprot id: A0A2R9ABY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9597:CALB1
gene id: 9597:CALB1
uniprot id: A0A2R9CNG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9597:RBP2
gene id: 9597:RBP2
uniprot id: A0A2R9APR6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:DIMT1
gene id: 9597:DIMT1
uniprot id: A0A2R9AYI1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9597:LOC100976125
gene id: 9597:LOC100976125
uniprot id: A0A2R8ZCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CDK2AP1
gene id: 9597:CDK2AP1
uniprot id: A0A2R9AF25
names: Similarity
messages: Belongs to the CDK2AP family.

9597:ME2
gene id: 9597:ME2
uniprot id: A0A2R9BBS9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9597:TMED1
gene id: 9597:TMED1
uniprot id: A0A2R9AJK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:CCS
gene id: 9597:CCS
uniprot id: A0A2R9AT42
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9597:HMGN2
gene id: 9597:HMGN2
uniprot id: A0A2R9AT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9597:CTSS
gene id: 9597:CTSS
uniprot id: A0A2R9ABI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:PSMA2
gene id: 9597:PSMA2
uniprot id: A0A2R9BBY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:CLDN8
gene id: 9597:CLDN8
uniprot id: A0A2R9API0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:DNA2
gene id: 9597:DNA2
uniprot id: A0A2R9BE95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9597:FAM24A
gene id: 9597:FAM24A
uniprot id: A0A2R9A5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

9597:TOX4
gene id: 9597:TOX4
uniprot id: A0A2R9B9J5
names: Subcellular Location Annotation
messages: Nucleus

9597:SEPTIN3
gene id: 9597:SEPTIN3
uniprot id: A0A2R8ZHA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:NUF2
gene id: 9597:NUF2
uniprot id: A0A2R9CF19
names: Similarity
messages: Belongs to the NUF2 family.

9597:CHST4
gene id: 9597:CHST4
uniprot id: A0A2R9AVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9597:SNRPA1
gene id: 9597:SNRPA1
uniprot id: A0A2R9ASR3
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9597:SUPT16H
gene id: 9597:SUPT16H
uniprot id: A0A2R8ZBD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9597:GRB7
gene id: 9597:GRB7
uniprot id: A0A2R9AMK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9597:LOC100968477
gene id: 9597:LOC100968477
uniprot id: A0A2R8ZLB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9597:KRT12
gene id: 9597:KRT12
uniprot id: A0A2R9B0H7
names: Similarity
messages: Belongs to the intermediate filament family.

9597:LOC100983857
gene id: 9597:LOC100983857
uniprot id: A0A2R9BYB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9597:PRICKLE2
gene id: 9597:PRICKLE2
uniprot id: A0A2R9BE32
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9597:FA2H
gene id: 9597:FA2H
uniprot id: A0A2R8ZJK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100980208
gene id: 9597:LOC100980208
uniprot id: A0A2R8ZGR2
names: Similarity
messages: Belongs to the FAM47 family.

9597:LOC100977566
gene id: 9597:LOC100977566
uniprot id: A0A2R9CF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9597:ANAPC16
gene id: 9597:ANAPC16
uniprot id: A0A2R9BSH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9597:MED17
gene id: 9597:MED17
uniprot id: A0A2R9BM32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:RUSF1
gene id: 9597:RUSF1
uniprot id: A0A2R9BAX6
names: Similarity
messages: Belongs to the RUS1 family.

9597:LOC100981041
gene id: 9597:LOC100981041
uniprot id: A0A2R9APZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:EIF4A1
gene id: 9597:EIF4A1
uniprot id: A0A2R9C6F8
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9597:CASP9
gene id: 9597:CASP9
uniprot id: A0A2R9CHF2
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:LOC100973589
gene id: 9597:LOC100973589
uniprot id: A0A2R8ZNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:IL3
gene id: 9597:IL3
uniprot id: A0A2R9B411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

9597:FZD3
gene id: 9597:FZD3
uniprot id: A0A2R9AS81
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CSN1S1
gene id: 9597:CSN1S1
uniprot id: A0A2R9AYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Secreted

9597:MRPL30
gene id: 9597:MRPL30
uniprot id: A0A2R9BUE6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9597:ADGRL3
gene id: 9597:ADGRL3
uniprot id: A0A2R9BNZ0
names: Subcellular Location Annotation
messages: Membrane

9597:PTK7
gene id: 9597:PTK7
uniprot id: A0A2R9BXV6
uniprot id: A0A2R9BXW9
names: Subcellular Location Annotation
messages: Membrane

9597:ZMPSTE24
gene id: 9597:ZMPSTE24
uniprot id: A0A2R9B1R7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9597:LCA5L
gene id: 9597:LCA5L
uniprot id: A0A2R9B9U9
names: Similarity
messages: Belongs to the LCA5 family.

9597:OAS2
gene id: 9597:OAS2
uniprot id: A0A2R9B084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9597:CAPRIN2
gene id: 9597:CAPRIN2
uniprot id: A0A2R9C5Z2
uniprot id: A0A2R9C6B2
uniprot id: A0A2R9C8Q1
names: Similarity
messages: Belongs to the caprin family.

9597:UBE2K
gene id: 9597:UBE2K
uniprot id: A0A2R9ARK0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:ST6GALNAC6
gene id: 9597:ST6GALNAC6
uniprot id: A0A2R9BCB6
uniprot id: A0A2R9BG11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:PGF
gene id: 9597:PGF
uniprot id: A0A2R9AEK8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9597:HAT1
gene id: 9597:HAT1
uniprot id: A0A2R9CI44
uniprot id: A0A2R9CI71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9597:MAPKAPK3
gene id: 9597:MAPKAPK3
uniprot id: A0A2R9A884
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:VASN
gene id: 9597:VASN
uniprot id: A0A2R8Z7P3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:APOC2
gene id: 9597:APOC2
uniprot id: A0A2R9CC44
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9597:LOC100992550
gene id: 9597:LOC100992550
uniprot id: A0A2R8ZJC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CLDN19
gene id: 9597:CLDN19
uniprot id: A0A2R9BUY2
uniprot id: A0A2R9BYC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:SENP8
gene id: 9597:SENP8
uniprot id: A0A2R8Z824
names: Similarity
messages: Belongs to the peptidase C48 family.

9597:MRPL54
gene id: 9597:MRPL54
uniprot id: A0A2R9CEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9597:GATM
gene id: 9597:GATM
uniprot id: A0A2R9CTN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9597:LOC100982452
gene id: 9597:LOC100982452
uniprot id: A0A2R8ZVS6
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:GPR89A
gene id: 9597:GPR89A
uniprot id: A0A2R9A501
uniprot id: A0A2R9A672
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9597:MARCO
gene id: 9597:MARCO
uniprot id: A0A2R9BMI0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LCTL
gene id: 9597:LCTL
uniprot id: A0A2R9C2W1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9597:OAT
gene id: 9597:OAT
uniprot id: A0A2R9B3M7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:VSX1
gene id: 9597:VSX1
uniprot id: A0A2R9BYB3
uniprot id: A0A2R9BYB8
uniprot id: A0A2R9C1L9
names: Subcellular Location Annotation
messages: Nucleus

9597:CYP2B6
gene id: 9597:CYP2B6
uniprot id: A0A2R9AIM3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:SNX19
gene id: 9597:SNX19
uniprot id: A0A2R9B0F0
names: Similarity
messages: Belongs to the sorting nexin family.

9597:LOC100987218
gene id: 9597:LOC100987218
uniprot id: A0A2R8Z9Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:SCGB2A1
gene id: 9597:SCGB2A1
uniprot id: A0A2R9C1P9
names: Subcellular Location Annotation
messages: Secreted

9597:GLRX
gene id: 9597:GLRX
uniprot id: A0A2R9CS70
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9597:IST1
gene id: 9597:IST1
uniprot id: A0A2R9CK94
uniprot id: A0A2R9CMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9597:HAO1
gene id: 9597:HAO1
uniprot id: A0A2R8ZF43
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9597:TPRKB
gene id: 9597:TPRKB
uniprot id: A0A2R9ALN7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9597:SST
gene id: 9597:SST
uniprot id: A0A2R8ZYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9597:CFL2
gene id: 9597:CFL2
uniprot id: A0A2R8Z9R1
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9597:KCNS2
gene id: 9597:KCNS2
uniprot id: A0A2R8Z807
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:CTSO
gene id: 9597:CTSO
uniprot id: A0A2R9CA02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:LOC100995078
gene id: 9597:LOC100995078
uniprot id: A0A2R8ZC00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:DHRS11
gene id: 9597:DHRS11
uniprot id: A0A2R9AKF4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:BIRC7
gene id: 9597:BIRC7
uniprot id: A0A2R8ZVR3
names: Similarity
messages: Belongs to the IAP family.

9597:GPR119
gene id: 9597:GPR119
uniprot id: A0A2R8ZEY9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:JAG1
gene id: 9597:JAG1
uniprot id: A0A2R9AZ83
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9597:LOC100979818
gene id: 9597:LOC100979818
uniprot id: A0A2R9CML0
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9597:C11H11orf87
gene id: 9597:C11H11orf87
uniprot id: A0A2R8Z6R7
names: Subcellular Location Annotation
messages: Membrane

9597:STX19
gene id: 9597:STX19
uniprot id: A0A2R8ZIZ3
names: Similarity
messages: Belongs to the syntaxin family.

9597:ABHD1
gene id: 9597:ABHD1
uniprot id: A0A2R8ZY70
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9597:NR3C1
gene id: 9597:NR3C1
uniprot id: A0A2R9BT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9597:DOLK
gene id: 9597:DOLK
uniprot id: A0A2R8ZFN2
names: Similarity
messages: Belongs to the polyprenol kinase family.

9597:AMOT
gene id: 9597:AMOT
uniprot id: A0A2R9BTE3
names: Similarity
messages: Belongs to the angiomotin family.

9597:SASS6
gene id: 9597:SASS6
uniprot id: A0A2R9ALG5
names: Subcellular Location Annotation
messages: centrosome

9597:TSPAN16
gene id: 9597:TSPAN16
uniprot id: A0A2R9AUJ0
uniprot id: A0A2R9B0E9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:EEF2
gene id: 9597:EEF2
uniprot id: A0A2R9CEE9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9597:NRCAM
gene id: 9597:NRCAM
uniprot id: A0A2R9BC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9597:STOM
gene id: 9597:STOM
uniprot id: A0A2R9AUH5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9597:USP16
gene id: 9597:USP16
uniprot id: A0A2R8ZKJ4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9597:GSG1
gene id: 9597:GSG1
uniprot id: A0A2R9C053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9597:FASLG
gene id: 9597:FASLG
uniprot id: A0A2R9A5R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9597:DIP2A
gene id: 9597:DIP2A
uniprot id: A0A2R9BR91
uniprot id: A0A2R9BRJ5
names: Similarity
messages: Belongs to the DIP2 family.

9597:TOMM7
gene id: 9597:TOMM7
uniprot id: A0A2R9C848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:BATF
gene id: 9597:BATF
uniprot id: A0A2R9BMU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9597:SDR42E2
gene id: 9597:SDR42E2
uniprot id: A0A2R8ZYK6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9597:RO60
gene id: 9597:RO60
uniprot id: A0A2R9CN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9597:ARHGEF12
gene id: 9597:ARHGEF12
uniprot id: A0A2R9AYK8
uniprot id: A0A2R9AZ06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9597:KIT
gene id: 9597:KIT
uniprot id: A0A2R9AUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:POMGNT2
gene id: 9597:POMGNT2
uniprot id: A0A2R8ZIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SH3GL3
gene id: 9597:SH3GL3
uniprot id: A0A2R8Z992
uniprot id: A0A2R8Z996
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9597:SERPINA4
gene id: 9597:SERPINA4
uniprot id: A0A2R8ZZK5
names: Similarity
messages: Belongs to the serpin family.

9597:TRNAU1AP
gene id: 9597:TRNAU1AP
uniprot id: A0A2R9AW67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9597:ACTR1A
gene id: 9597:ACTR1A
uniprot id: A0A2R9AD10
names: Similarity
messages: Belongs to the actin family.

9597:PPEF2
gene id: 9597:PPEF2
uniprot id: A0A2R9AD26
names: Similarity
messages: Belongs to the PPP phosphatase family.

9597:ASCC3
gene id: 9597:ASCC3
uniprot id: A0A2R9AJM0
names: Similarity
messages: Belongs to the helicase family.

9597:MDGA2
gene id: 9597:MDGA2
uniprot id: A0A2R9BP11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:XRN2
gene id: 9597:XRN2
uniprot id: A0A2R9ATM4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9597:HNRNPC
gene id: 9597:HNRNPC
uniprot id: A0A2R9AWL7
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9597:POT1
gene id: 9597:POT1
uniprot id: A0A2R9BKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9597:LOC100993994
gene id: 9597:LOC100993994
uniprot id: A0A2R8ZDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LSM4
gene id: 9597:LSM4
uniprot id: A0A2R9CTE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9597:DSP
gene id: 9597:DSP
uniprot id: A0A2R9AM84
names: Subcellular Location Annotation
messages: cytoskeleton

9597:MAP4
gene id: 9597:MAP4
uniprot id: A0A2R9CB91
uniprot id: A0A2R9CE05
uniprot id: A0A2R9CE15
names: Subcellular Location Annotation
messages: cytoskeleton

9597:PLA2G4E
gene id: 9597:PLA2G4E
uniprot id: A0A2R9A0R6
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9597:PSMF1
gene id: 9597:PSMF1
uniprot id: A0A2R9B9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9597:B4GALT1
gene id: 9597:B4GALT1
uniprot id: A0A2R9BQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:LOC100968365
gene id: 9597:LOC100968365
uniprot id: A0A2R8ZJM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9597:TSSK2
gene id: 9597:TSSK2
uniprot id: A0A2R8ZF39
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ANO1
gene id: 9597:ANO1
uniprot id: A0A2R8ZND9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:YBEY
gene id: 9597:YBEY
uniprot id: A0A2R9AKQ5
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9597:C15H15orf40
gene id: 9597:C15H15orf40
uniprot id: A0A2R8ZHU9
names: Similarity
messages: Belongs to the UPF0235 family.

9597:ELP6
gene id: 9597:ELP6
uniprot id: A0A2R9BXF5
names: Similarity
messages: Belongs to the ELP6 family.

9597:ATP6V0E1
gene id: 9597:ATP6V0E1
uniprot id: A0A2R9BNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:PCDH17
gene id: 9597:PCDH17
uniprot id: A0A2R9BB59
uniprot id: A0A2R9BCI6
names: Subcellular Location Annotation
messages: Membrane

9597:KCNA1
gene id: 9597:KCNA1
uniprot id: A0A2R8ZFZ7
names: Subcellular Location Annotation
messages: Membrane

9597:MTERF4
gene id: 9597:MTERF4
uniprot id: A0A2R9CDW1
names: Similarity
messages: Belongs to the mTERF family.

9597:CYP2U1
gene id: 9597:CYP2U1
uniprot id: A0A2R9CKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:JAGN1
gene id: 9597:JAGN1
uniprot id: A0A2R9BJF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MYO1C
gene id: 9597:MYO1C
uniprot id: A0A2R8ZQ29
uniprot id: A0A2R8ZVX3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:NOP16
gene id: 9597:NOP16
uniprot id: A0A2R9B6J4
uniprot id: A0A2R9B8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9597:GALNT5
gene id: 9597:GALNT5
uniprot id: A0A2R9C4V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:TARS3
gene id: 9597:TARS3
uniprot id: A0A2R9BXX9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:WAS
gene id: 9597:WAS
uniprot id: A0A2R9AUP0
names: Subcellular Location Annotation
messages: Nucleus

9597:GPC1
gene id: 9597:GPC1
uniprot id: A0A2R9BL44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

9597:STK32A
gene id: 9597:STK32A
uniprot id: A0A2R8ZXG1
uniprot id: A0A2R8ZYM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:KDM4A
gene id: 9597:KDM4A
uniprot id: A0A2R9BW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9597:DPT
gene id: 9597:DPT
uniprot id: A0A2R8ZEN1
names: Similarity
messages: Belongs to the dermatopontin family.

9597:SEMA3G
gene id: 9597:SEMA3G
uniprot id: A0A2R9ASH9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DDOST
gene id: 9597:DDOST
uniprot id: A0A2R9BPC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

9597:GC
gene id: 9597:GC
uniprot id: A0A2R8ZB94
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9597:RUNX1
gene id: 9597:RUNX1
uniprot id: A0A2R8Z7Z3
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9597:CASR
gene id: 9597:CASR
uniprot id: A0A2R9BDK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:NMD3
gene id: 9597:NMD3
uniprot id: A0A2R9CKL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9597:SET
gene id: 9597:SET
uniprot id: A0A2R9A757
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:TSPAN17
gene id: 9597:TSPAN17
uniprot id: A0A2R9BJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:LETMD1
gene id: 9597:LETMD1
uniprot id: A0A2R9BPZ9
uniprot id: A0A2R9BZ08
names: Subcellular Location Annotation
messages: Membrane

9597:MRI1
gene id: 9597:MRI1
uniprot id: A0A2R9ASE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9597:GPR50
gene id: 9597:GPR50
uniprot id: A0A2R9BYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:NPY1R
gene id: 9597:NPY1R
uniprot id: A0A2R9CMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:VWC2L
gene id: 9597:VWC2L
uniprot id: A0A2R9BKB5
names: Subcellular Location Annotation
messages: Synapse

9597:LOC100986527
gene id: 9597:LOC100986527
uniprot id: A0A2R9BTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9597:ETS2
gene id: 9597:ETS2
uniprot id: A0A2R9A0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9597:FN3K
gene id: 9597:FN3K
uniprot id: A0A2R9CI92
names: Similarity
messages: Belongs to the fructosamine kinase family.

9597:SUMO1
gene id: 9597:SUMO1
uniprot id: A0A2R9BUH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9597:HESX1
gene id: 9597:HESX1
uniprot id: A0A2R8ZZ78
uniprot id: A1YGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANF homeobox family.
messages: Can form heterodimers with PROP1 in binding to DNA. Interacts with TLE1 (By similarity).
messages: Nucleus
messages: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).

9597:LYPLA2
gene id: 9597:LYPLA2
uniprot id: A0A2R8ZLB5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9597:SCAMP5
gene id: 9597:SCAMP5
uniprot id: A0A2R9CE85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:LOC100977441
gene id: 9597:LOC100977441
uniprot id: A0A2R9AN85
names: Similarity
messages: Belongs to the cytochrome b5 family.

9597:GALNT14
gene id: 9597:GALNT14
uniprot id: A0A2R9BJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:PGLYRP3
gene id: 9597:PGLYRP3
uniprot id: A0A2R9CMU3
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9597:LOC100981444
gene id: 9597:LOC100981444
uniprot id: Q646C7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:DEFB119
gene id: 9597:DEFB119
uniprot id: A0A2R9A5R6
uniprot id: A0A2R9AAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:P2RX3
gene id: 9597:P2RX3
uniprot id: A0A2R9BII3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:ZKSCAN8
gene id: 9597:ZKSCAN8
uniprot id: A1YG60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ADSL
gene id: 9597:ADSL
uniprot id: A0A2R9AAB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9597:LOC100975679
gene id: 9597:LOC100975679
uniprot id: A0A2R9AMC4
names: Similarity
messages: Belongs to the FAH family.

9597:MGAT1
gene id: 9597:MGAT1
uniprot id: A0A2R8Z919
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9597:EIF4A2
gene id: 9597:EIF4A2
uniprot id: A0A2R8ZFC3
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9597:GNPNAT1
gene id: 9597:GNPNAT1
uniprot id: A0A2R9AAM1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9597:SARM1
gene id: 9597:SARM1
uniprot id: A0A2R9B3Z7
names: Similarity
messages: Belongs to the SARM1 family.

9597:LOC100977568
gene id: 9597:LOC100977568
uniprot id: A0A2R9AU43
uniprot id: A0A2R9B032
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:TGM6
gene id: 9597:TGM6
uniprot id: A0A2R9AVL9
uniprot id: A0A2R9B1D9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:ACTL7B
gene id: 9597:ACTL7B
uniprot id: A0A2R8ZJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9597:VIP
gene id: 9597:VIP
uniprot id: A0A2R9AEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9597:CDKAL1
gene id: 9597:CDKAL1
uniprot id: A0A2R8ZMJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9597:NCSTN
gene id: 9597:NCSTN
uniprot id: A0A2R9ATE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9597:MIP
gene id: 9597:MIP
uniprot id: A0A2R9CLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:TRMT11
gene id: 9597:TRMT11
uniprot id: A0A2R9ABD1
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9597:TSR1
gene id: 9597:TSR1
uniprot id: A0A2R9BAB2
names: Subcellular Location Annotation
messages: nucleolus

9597:CHRNB4
gene id: 9597:CHRNB4
uniprot id: A0A2R9A5J9
uniprot id: A0A2R9A6Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:BLOC1S2
gene id: 9597:BLOC1S2
uniprot id: A0A2R9CI40
uniprot id: A0A2R9CRI6
names: Similarity
messages: Belongs to the BLOC1S2 family.

9597:LOC100976704
gene id: 9597:LOC100976704
uniprot id: A0A2R9BLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:LTBR
gene id: 9597:LTBR
uniprot id: A0A2R9BG90
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:C3AR1
gene id: 9597:C3AR1
uniprot id: A0A2R8ZLW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9597:SLC22A2
gene id: 9597:SLC22A2
uniprot id: A0A2R8ZCZ9
uniprot id: A0A2R8ZD17
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9597:UBE3A
gene id: 9597:UBE3A
uniprot id: A0A2R9BJP4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9597:MPP6
gene id: 9597:MPP6
uniprot id: A0A2R9BAP0
names: Similarity
messages: Belongs to the MAGUK family.

9597:ZNF891
gene id: 9597:ZNF891
uniprot id: A0A2R8Z7T5
names: Function
messages: May be involved in transcriptional regulation.

9597:EGR3
gene id: 9597:EGR3
uniprot id: A0A2R9A862
uniprot id: A0A2R9A866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9597:TRMT6
gene id: 9597:TRMT6
uniprot id: A0A2R9BE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

9597:FDFT1
gene id: 9597:FDFT1
uniprot id: A0A2R9A4B7
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9597:SLC25A23
gene id: 9597:SLC25A23
uniprot id: A0A2R9BZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:HDAC4
gene id: 9597:HDAC4
uniprot id: A0A2R9B8W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9597:PSMD5
gene id: 9597:PSMD5
uniprot id: A0A2R9C0K4
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9597:TAC3
gene id: 9597:TAC3
uniprot id: A0A2R9BYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9597:MOB2
gene id: 9597:MOB2
uniprot id: A0A2R9ADL9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:CA3
gene id: 9597:CA3
uniprot id: A0A2R9CFW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9597:TGFB1I1
gene id: 9597:TGFB1I1
uniprot id: A0A2R9BBV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Nucleus matrix
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: cytoskeleton
messages: focal adhesion

9597:FUNDC2
gene id: 9597:FUNDC2
uniprot id: A0A2R9A2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9597:LOC103784268
gene id: 9597:LOC103784268
uniprot id: A0A2R9B6V9
names: Function
messages: May be involved in transcriptional regulation.

9597:NECAP2
gene id: 9597:NECAP2
uniprot id: A0A2R9CEW6
uniprot id: A0A2R9CPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9597:SARDH
gene id: 9597:SARDH
uniprot id: A0A2R8ZS08
names: Similarity
messages: Belongs to the GcvT family.

9597:NME3
gene id: 9597:NME3
uniprot id: A0A2R9A983
names: Similarity
messages: Belongs to the NDK family.

9597:TSPAN1
gene id: 9597:TSPAN1
uniprot id: A0A2R9C4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:REC8
gene id: 9597:REC8
uniprot id: A0A2R9AFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:COG4
gene id: 9597:COG4
uniprot id: A0A2R9A7R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9597:CNTFR
gene id: 9597:CNTFR
uniprot id: A0A2R9C7G4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9597:ITGA2
gene id: 9597:ITGA2
uniprot id: A0A2R9CTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:IL18RAP
gene id: 9597:IL18RAP
uniprot id: A0A2R9A4V6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:COL4A4
gene id: 9597:COL4A4
uniprot id: A0A2R9BIA2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9597:SLC25A16
gene id: 9597:SLC25A16
uniprot id: A0A2R9CJG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:EIF2S1
gene id: 9597:EIF2S1
uniprot id: A0A2R9CGS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9597:MED8
gene id: 9597:MED8
uniprot id: A0A2R9B3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:GFRA1
gene id: 9597:GFRA1
uniprot id: A0A2R9AIA1
uniprot id: A0A2R9AQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9597:PSMB7
gene id: 9597:PSMB7
uniprot id: A0A2R9CID4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9597:IGF2
gene id: 9597:IGF2
uniprot id: A0A2R9BAY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9597:POLA1
gene id: 9597:POLA1
uniprot id: A0A2R9CFV7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9597:PRKD3
gene id: 9597:PRKD3
uniprot id: A0A2R9AG38
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9597:MARK2
gene id: 9597:MARK2
uniprot id: A0A2R9AQR7
uniprot id: A0A2R9AR61
uniprot id: A0A2R9AR77
uniprot id: A0A2R9AV64
uniprot id: A0A2R9AV99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:SPA17
gene id: 9597:SPA17
uniprot id: A0A2R9BDD1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9597:TCTEX1D2
gene id: 9597:TCTEX1D2
uniprot id: A0A2R9AQS6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:FAM161B
gene id: 9597:FAM161B
uniprot id: A0A2R9BC30
names: Similarity
messages: Belongs to the FAM161 family.

9597:GET3
gene id: 9597:GET3
uniprot id: A0A2R9CEY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9597:ARMT1
gene id: 9597:ARMT1
uniprot id: A0A2R9ABL2
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9597:SVOPL
gene id: 9597:SVOPL
uniprot id: A0A2R9AAU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9597:LOC100974743
gene id: 9597:LOC100974743
uniprot id: A0A2R9C869
names: Subcellular Location Annotation
messages: Membrane

9597:SPHKAP
gene id: 9597:SPHKAP
uniprot id: A0A2R8ZTF4
uniprot id: A0A2R8ZZ69
names: Similarity
messages: Belongs to the AKAP110 family.

9597:ME1
gene id: 9597:ME1
uniprot id: A0A2R9C9K1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9597:ECI1
gene id: 9597:ECI1
uniprot id: A0A2R9BNM9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:NAA60
gene id: 9597:NAA60
uniprot id: A0A2R9BVX1
uniprot id: A0A2R9C509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9597:ZDHHC13
gene id: 9597:ZDHHC13
uniprot id: A0A2R9CM25
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:TG
gene id: 9597:TG
uniprot id: A0A2R9AW86
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ARV1
gene id: 9597:ARV1
uniprot id: A0A2R9CIA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9597:SLC39A6
gene id: 9597:SLC39A6
uniprot id: A0A2R9A211
names: Subcellular Location Annotation
messages: Membrane

9597:SPEM1
gene id: 9597:SPEM1
uniprot id: A0A2R9CLU4
names: Subcellular Location Annotation
messages: Membrane

9597:BPIFA1
gene id: 9597:BPIFA1
uniprot id: A0A2R9B1T5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Secreted

9597:B4GALNT1
gene id: 9597:B4GALNT1
uniprot id: A0A2R9BJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:EIF3G
gene id: 9597:EIF3G
uniprot id: A0A2R8ZXP0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9597:HSD17B11
gene id: 9597:HSD17B11
uniprot id: A0A2R8ZH80
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:MINDY1
gene id: 9597:MINDY1
uniprot id: A0A2R9BTU8
uniprot id: A0A2R9BZD6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9597:AGMAT
gene id: 9597:AGMAT
uniprot id: A0A2R9A166
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9597:CYFIP2
gene id: 9597:CYFIP2
uniprot id: A0A2R9CAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9597:RNF111
gene id: 9597:RNF111
uniprot id: A0A2R8ZS76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9597:TSHZ2
gene id: 9597:TSHZ2
uniprot id: A0A2R9AIL8
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9597:LOC100979108
gene id: 9597:LOC100979108
uniprot id: A0A2R8ZB51
uniprot id: A0A2R8ZB67
uniprot id: A0A2R8ZB71
uniprot id: A0A2R8ZBA4
uniprot id: A0A2R8ZBU7
uniprot id: A0A2R8ZF55
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9597:LOC100975556
gene id: 9597:LOC100975556
uniprot id: A0A2R8ZFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:NAXD
gene id: 9597:NAXD
uniprot id: A0A2R9AZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

9597:SSRP1
gene id: 9597:SSRP1
uniprot id: A0A2R9BSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9597:ISY1
gene id: 9597:ISY1
uniprot id: A0A2R9CAA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9597:MED4
gene id: 9597:MED4
uniprot id: A0A2R9BPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:MRPL15
gene id: 9597:MRPL15
uniprot id: A0A2R9AXT2
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9597:PUSL1
gene id: 9597:PUSL1
uniprot id: A0A2R9A5N5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9597:LCN15
gene id: 9597:LCN15
uniprot id: A0A2R9A1I4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9597:PDP1
gene id: 9597:PDP1
uniprot id: A0A2R8ZRK3
names: Similarity
messages: Belongs to the PP2C family.

9597:YARS2
gene id: 9597:YARS2
uniprot id: A0A2R9BFE5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:ZSCAN23
gene id: 9597:ZSCAN23
uniprot id: A0A2R9BD00
names: Subcellular Location Annotation
messages: Nucleus

9597:CCN3
gene id: 9597:CCN3
uniprot id: A0A2R9ABL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:ZCCHC8
gene id: 9597:ZCCHC8
uniprot id: A0A2R9CP66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9597:ACTL9
gene id: 9597:ACTL9
uniprot id: A0A2R8ZEN5
names: Similarity
messages: Belongs to the actin family.

9597:KIN
gene id: 9597:KIN
uniprot id: A0A2R9BFF5
names: Similarity
messages: Belongs to the KIN17 family.

9597:DPF3
gene id: 9597:DPF3
uniprot id: A0A2R9BH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

9597:MMAA
gene id: 9597:MMAA
uniprot id: A0A2R9AIX0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9597:RFC4
gene id: 9597:RFC4
uniprot id: A0A2R9C3P2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9597:MACIR
gene id: 9597:MACIR
uniprot id: A0A2R8ZMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9597:LOC100996106
gene id: 9597:LOC100996106
uniprot id: A0A2R8ZP45
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SNRNP27
gene id: 9597:SNRNP27
uniprot id: A0A2R9BSD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9597:PORCN
gene id: 9597:PORCN
uniprot id: A0A2R9AQ84
uniprot id: A0A2R9AQT1
names: Subcellular Location Annotation
messages: Membrane

9597:PRIMPOL
gene id: 9597:PRIMPOL
uniprot id: A0A2R9BM03
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9597:ETV3L
gene id: 9597:ETV3L
uniprot id: A0A2R9A4Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:NAGK
gene id: 9597:NAGK
uniprot id: A0A2R9BU47
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9597:NOX1
gene id: 9597:NOX1
uniprot id: A0A2R8ZK08
uniprot id: A0A2R8ZL32
uniprot id: A0A2R8ZMV9
names: Subcellular Location Annotation
messages: Membrane

9597:MANBA
gene id: 9597:MANBA
uniprot id: A0A2R9A4B3
uniprot id: A0A2R9A5H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9597:ERMN
gene id: 9597:ERMN
uniprot id: A0A2R9AT88
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9597:LOC100968447
gene id: 9597:LOC100968447
uniprot id: A0A2R8ZB01
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:MRGPRX3
gene id: 9597:MRGPRX3
uniprot id: A0A2R8ZCA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9597:NDUFS4
gene id: 9597:NDUFS4
uniprot id: A0A2R9ANH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9597:HSCB
gene id: 9597:HSCB
uniprot id: A0A2R9ALN2
names: Similarity
messages: Belongs to the HscB family.

9597:NELFE
gene id: 9597:NELFE
uniprot id: A0A2R9BWZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9597:UBR4
gene id: 9597:UBR4
uniprot id: A0A2R8ZK63
names: Similarity
messages: Belongs to the UBR4 family.

9597:S1PR2
gene id: 9597:S1PR2
uniprot id: A0A2R8ZI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:CAMKK2
gene id: 9597:CAMKK2
uniprot id: A0A2R9B8E6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ITIH2
gene id: 9597:ITIH2
uniprot id: A0A2R8Z603
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:CMAS
gene id: 9597:CMAS
uniprot id: A0A2R9BYY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9597:EPCAM
gene id: 9597:EPCAM
uniprot id: A0A2R9A8B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9597:KRBOX1
gene id: 9597:KRBOX1
uniprot id: A0A2R9BRL7
names: Function
messages: May be involved in transcriptional regulation.

9597:NPR2
gene id: 9597:NPR2
uniprot id: A0A2R9ADF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9597:ZNF718
gene id: 9597:ZNF718
uniprot id: A0A2R9AL82
names: Function
messages: May be involved in transcriptional regulation.

9597:POLR3H
gene id: 9597:POLR3H
uniprot id: A0A2R9AEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9597:TRMO
gene id: 9597:TRMO
uniprot id: A0A2R8ZDR4
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9597:ATP4B
gene id: 9597:ATP4B
uniprot id: A0A2R8ZBW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9597:FGF12
gene id: 9597:FGF12
uniprot id: A0A2R9B7Q7
uniprot id: A0A2R9BAP4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:LAMTOR5
gene id: 9597:LAMTOR5
uniprot id: A0A2R9CGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9597:ABL1
gene id: 9597:ABL1
uniprot id: A0A2R9BA11
uniprot id: A0A2R9BBG8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:INPP5K
gene id: 9597:INPP5K
uniprot id: A0A2R9CCA5
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9597:LRWD1
gene id: 9597:LRWD1
uniprot id: A0A2R8ZZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9597:C12H12orf57
gene id: 9597:C12H12orf57
uniprot id: A0A2R9CN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9597:KIF16B
gene id: 9597:KIF16B
uniprot id: A0A2R8ZGR0
uniprot id: A0A2R8ZK03
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:LOC100978482
gene id: 9597:LOC100978482
uniprot id: A0A2R8ZP43
names: Similarity
messages: Belongs to the LCE family.

9597:WBP4
gene id: 9597:WBP4
uniprot id: A0A2R9B222
names: Subcellular Location Annotation
messages: Nucleus

9597:MYO19
gene id: 9597:MYO19
uniprot id: A0A2R9AXU1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:LOC100987081
gene id: 9597:LOC100987081
uniprot id: A0A2R9C8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9597:RPS20
gene id: 9597:RPS20
uniprot id: A0A2R8Z8W6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9597:HOXB5
gene id: 9597:HOXB5
uniprot id: A0A2R9C1J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:TP53INP1
gene id: 9597:TP53INP1
uniprot id: A0A2R9B7P0
uniprot id: A0A2R9B7Q8
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9597:SRSF1
gene id: 9597:SRSF1
uniprot id: A0A2R9CI18
names: Similarity
messages: Belongs to the splicing factor SR family.

9597:RPS29
gene id: 9597:RPS29
uniprot id: A0A2R9AK38
uniprot id: A0A2R9AS94
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9597:TMTC2
gene id: 9597:TMTC2
uniprot id: A0A2R9CJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9597:HPSE
gene id: 9597:HPSE
uniprot id: A0A2R9BIC6
uniprot id: A0A2R9BLV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9597:MTMR6
gene id: 9597:MTMR6
uniprot id: A0A2R9B6J7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:IL21
gene id: 9597:IL21
uniprot id: A0A2R9BR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9597:TNFSF13
gene id: 9597:TNFSF13
uniprot id: A0A2R8ZPT3
uniprot id: A0A2R8ZVN2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:CYP4F3
gene id: 9597:CYP4F3
uniprot id: A0A2R9BI89
uniprot id: A0A2R9BS15
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:TMPRSS6
gene id: 9597:TMPRSS6
uniprot id: A0A2R9CIH7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MIOX
gene id: 9597:MIOX
uniprot id: A0A2R9BVT3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9597:AKAP8L
gene id: 9597:AKAP8L
uniprot id: A0A2R9A7D9
names: Similarity
messages: Belongs to the AKAP95 family.

9597:HOATZ
gene id: 9597:HOATZ
uniprot id: A0A2R9A431
uniprot id: A0A2R9A436
names: Similarity
messages: Belongs to the HOATZ family.

9597:LOC103783475
gene id: 9597:LOC103783475
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:SART1
gene id: 9597:SART1
uniprot id: A0A2R9ABI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9597:CD79B
gene id: 9597:CD79B
uniprot id: A0A2R9C3B1
uniprot id: A0A2R9C3B4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:SCD5
gene id: 9597:SCD5
uniprot id: A0A2R8ZTN7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9597:CALCA
gene id: 9597:CALCA
uniprot id: A0A2R9C2C6
uniprot id: A0A2R9C976
names: Similarity
messages: Belongs to the calcitonin family.

9597:POLR3D
gene id: 9597:POLR3D
uniprot id: A0A2R9A6A7
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100992080
gene id: 9597:LOC100992080
uniprot id: A0A2R9A8C6
names: Subcellular Location Annotation
messages: Nucleus

9597:GCNT2
gene id: 9597:GCNT2
uniprot id: A0A2R9C5N5
uniprot id: A0A2R9C5P1
uniprot id: A0A2R9C5P6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9597:POLR2H
gene id: 9597:POLR2H
uniprot id: A0A2R9BD68
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9597:MASP1
gene id: 9597:MASP1
uniprot id: A0A2R9BC56
uniprot id: A0A2R9BDD5
uniprot id: A0A2R9BDE3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:BBS7
gene id: 9597:BBS7
uniprot id: A0A2R9A8B3
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9597:SLC16A4
gene id: 9597:SLC16A4
uniprot id: A0A2R9B6J2
uniprot id: A0A2R9B803
uniprot id: A0A2R9B808
uniprot id: A0A2R9BDP9
names: Subcellular Location Annotation
messages: Membrane

9597:ARRDC3
gene id: 9597:ARRDC3
uniprot id: A0A2R9B0Y9
names: Similarity
messages: Belongs to the arrestin family.

9597:ANO3
gene id: 9597:ANO3
uniprot id: A0A2R9AXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9597:KHDC1L
gene id: 9597:KHDC1L
uniprot id: A0A2R8ZQ44
names: Similarity
messages: Belongs to the KHDC1 family.

9597:CDK5RAP1
gene id: 9597:CDK5RAP1
uniprot id: A0A2R8ZEK1
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9597:NQO1
gene id: 9597:NQO1
uniprot id: A0A2R9ATE6
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9597:OCEL1
gene id: 9597:OCEL1
uniprot id: A0A2R9AKJ9
names: Similarity
messages: Belongs to the ELL/occludin family.

9597:CNRIP1
gene id: 9597:CNRIP1
uniprot id: A0A2R9B9K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9597:ADRA2B
gene id: 9597:ADRA2B
uniprot id: A0A2R8ZLT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9597:TRIM36
gene id: 9597:TRIM36
uniprot id: A0A2R9BP33
names: Subcellular Location Annotation
messages: cytoskeleton

9597:FBN1
gene id: 9597:FBN1
uniprot id: A0A2R9CMD1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:DNAH8
gene id: 9597:DNAH8
uniprot id: A0A2R9CRG6
names: Similarity
messages: Belongs to the dynein heavy chain family.

9597:LTBP4
gene id: 9597:LTBP4
uniprot id: A0A2R9A3Z6
uniprot id: A0A2R9A9D5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:TMEM116
gene id: 9597:TMEM116
uniprot id: A0A2R9B7C8
names: Subcellular Location Annotation
messages: Membrane

9597:CAB39L
gene id: 9597:CAB39L
uniprot id: A0A2R9A8T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9597:SCRN2
gene id: 9597:SCRN2
uniprot id: A0A2R8ZYA1
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9597:HCN3
gene id: 9597:HCN3
uniprot id: A0A2R8ZUU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9597:LOC100969955
gene id: 9597:LOC100969955
uniprot id: A0A2R8ZMH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TPRA1
gene id: 9597:TPRA1
uniprot id: A0A2R8ZU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9597:SLCO6A1
gene id: 9597:SLCO6A1
uniprot id: A0A2R8ZPZ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CITED1
gene id: 9597:CITED1
uniprot id: A0A2R9BGL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9597:DCP1B
gene id: 9597:DCP1B
uniprot id: A0A2R9APP8
names: Similarity
messages: Belongs to the DCP1 family.

9597:FAM98C
gene id: 9597:FAM98C
uniprot id: A0A2R9CHR7
names: Similarity
messages: Belongs to the FAM98 family.

9597:ACMSD
gene id: 9597:ACMSD
uniprot id: A0A2R9BUU5
uniprot id: A0A2R9C3U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9597:SART3
gene id: 9597:SART3
uniprot id: A0A2R9C8C5
uniprot id: A0A2R9CJ43
names: Subcellular Location Annotation
messages: nucleoplasm

9597:TENT5C
gene id: 9597:TENT5C
uniprot id: A0A2R8ZMB3
names: Similarity
messages: Belongs to the TENT family.

9597:LMNB2
gene id: 9597:LMNB2
uniprot id: A0A2R9C2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9597:GCNT1
gene id: 9597:GCNT1
uniprot id: A0A2R8ZI21
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9597:FPR1
gene id: 9597:FPR1
uniprot id: A0A2R8ZPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:RMI1
gene id: 9597:RMI1
uniprot id: A0A2R8ZFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9597:MON1A
gene id: 9597:MON1A
uniprot id: A0A2R8ZDN4
uniprot id: A0A2R8ZJV7
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9597:TTC27
gene id: 9597:TTC27
uniprot id: A0A2R9A5I4
names: Similarity
messages: Belongs to the TTC27 family.

9597:TAF13
gene id: 9597:TAF13
uniprot id: A0A2R9BUH2
names: Subcellular Location Annotation
messages: Nucleus

9597:MAT1A
gene id: 9597:MAT1A
uniprot id: A0A2R9A4P2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9597:AFM
gene id: 9597:AFM
uniprot id: A0A2R8ZLB9
names: Subcellular Location Annotation
messages: Secreted

9597:CRBN
gene id: 9597:CRBN
uniprot id: A0A2R9CKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9597:ZNF558
gene id: 9597:ZNF558
uniprot id: A0A2R9BBF3
names: Function
messages: May be involved in transcriptional regulation.

9597:ASB15
gene id: 9597:ASB15
uniprot id: A0A2R9AAB1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:EGF
gene id: 9597:EGF
uniprot id: A0A2R8Z6N6
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100983833
gene id: 9597:LOC100983833
uniprot id: A0A2R8ZTV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100967520
gene id: 9597:LOC100967520
uniprot id: A0A2R9AY06
uniprot id: A0A2R9B3E8
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.
messages: May be involved in transcriptional regulation.

9597:SLC8B1
gene id: 9597:SLC8B1
uniprot id: A0A2R9BG26
names: Subcellular Location Annotation
messages: Membrane

9597:ATPAF2
gene id: 9597:ATPAF2
uniprot id: A0A2R9AH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9597:LOC100993258
gene id: 9597:LOC100993258
uniprot id: A0A2R9AM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RPL41
gene id: 9597:RPL41
uniprot id: A0A2R9CIZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.
messages: Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

9597:MMP10
gene id: 9597:MMP10
uniprot id: A0A2R8ZHX4
names: Similarity
messages: Belongs to the peptidase M10A family.

9597:IFNAR1
gene id: 9597:IFNAR1
uniprot id: A0A2R8ZEG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9597:LOC100990425
gene id: 9597:LOC100990425
uniprot id: A0A2R8ZE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:EXOSC2
gene id: 9597:EXOSC2
uniprot id: A0A2R9B0Y2
uniprot id: A0A2R9B7H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9597:PMEL
gene id: 9597:PMEL
uniprot id: A0A2R9B1T8
names: Similarity
messages: Belongs to the PMEL/NMB family.

9597:SNRPD3
gene id: 9597:SNRPD3
uniprot id: A0A2R9C1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9597:RNF43
gene id: 9597:RNF43
uniprot id: A0A2R9AYW1
uniprot id: A0A2R9AZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9597:KCNQ5
gene id: 9597:KCNQ5
uniprot id: A0A2R9C6I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:HGFAC
gene id: 9597:HGFAC
uniprot id: A0A2R8ZIN1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RC3H1
gene id: 9597:RC3H1
uniprot id: A0A2R9BT06
names: Subcellular Location Annotation
messages: P-body

9597:ALKAL1
gene id: 9597:ALKAL1
uniprot id: A0A2R9C248
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9597:NUP93
gene id: 9597:NUP93
uniprot id: A0A2R8ZYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9597:SMAD4
gene id: 9597:SMAD4
uniprot id: A0A2R9A0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:NCL
gene id: 9597:NCL
uniprot id: A0A2R8ZC94
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9597:SUPT6H
gene id: 9597:SUPT6H
uniprot id: A0A2R9BCW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9597:LOC100967935
gene id: 9597:LOC100967935
uniprot id: A0A2R9ALS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CCDC86
gene id: 9597:CCDC86
uniprot id: A0A2R9CMT4
names: Subcellular Location Annotation
messages: Nucleus

9597:TGM1
gene id: 9597:TGM1
uniprot id: A0A2R9AAS4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:ARHGEF1
gene id: 9597:ARHGEF1
uniprot id: A0A2R9C015
uniprot id: A0A2R9C029
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9597:KCNH3
gene id: 9597:KCNH3
uniprot id: A0A2R9ANM2
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9597:RAD9A
gene id: 9597:RAD9A
uniprot id: A0A2R9AJH6
names: Similarity
messages: Belongs to the rad9 family.

9597:PRPSAP2
gene id: 9597:PRPSAP2
uniprot id: A0A2R8ZC92
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9597:MYBL2
gene id: 9597:MYBL2
uniprot id: A0A2R9CF52
names: Subcellular Location Annotation
messages: Nucleus

9597:SSX2IP
gene id: 9597:SSX2IP
uniprot id: A0A2R9AFH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9597:MAT2A
gene id: 9597:MAT2A
uniprot id: A0A2R9C4C8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9597:LOC100974786
gene id: 9597:LOC100974786
uniprot id: A0A2R8ZAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SLC25A22
gene id: 9597:SLC25A22
uniprot id: A0A2R9CEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:GALM
gene id: 9597:GALM
uniprot id: A0A2R9BWD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9597:CAD
gene id: 9597:CAD
uniprot id: A0A2R9C7S3
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9597:RPS9
gene id: 9597:RPS9
uniprot id: A0A2R8ZZG1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9597:UNC45A
gene id: 9597:UNC45A
uniprot id: A0A2R9BKP6
names: Subcellular Location Annotation
messages: perinuclear region

9597:ZNF783
gene id: 9597:ZNF783
uniprot id: A0A2R8ZDR9
names: Function
messages: May be involved in transcriptional regulation.

9597:ENOPH1
gene id: 9597:ENOPH1
uniprot id: A0A2R9B7Z9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9597:GCDH
gene id: 9597:GCDH
uniprot id: A0A2R8ZQM3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:RNF20
gene id: 9597:RNF20
uniprot id: A0A2R9C5Y6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9597:LOC100974682
gene id: 9597:LOC100974682
uniprot id: A0A2R9BFA3
uniprot id: A0A2R9BGB7
uniprot id: A0A2R9BIW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ACSL5
gene id: 9597:ACSL5
uniprot id: A0A2R8Z7G2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9597:TXNL4B
gene id: 9597:TXNL4B
uniprot id: A0A2R9ATQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9597:PIGG
gene id: 9597:PIGG
uniprot id: A0A2R9A5W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:GRM4
gene id: 9597:GRM4
uniprot id: A0A2R9CHT6
uniprot id: A0A2R9CKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9597:DUSP13
gene id: 9597:DUSP13
uniprot id: A0A2R8Z997
uniprot id: A0A2R8ZDD0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9597:LOC100987642
gene id: 9597:LOC100987642
uniprot id: A0A2R8ZMP5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ITGB2
gene id: 9597:ITGB2
uniprot id: A0A2R9B178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9597:CX3CL1
gene id: 9597:CX3CL1
uniprot id: A0A2R9BJ74
names: Subcellular Location Annotation
messages: Secreted

9597:SLC16A9
gene id: 9597:SLC16A9
uniprot id: A0A2R9ABF7
names: Subcellular Location Annotation
messages: Membrane

9597:MTFR1L
gene id: 9597:MTFR1L
uniprot id: A0A2R9ACD1
uniprot id: A0A2R9AG98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9597:OTOG
gene id: 9597:OTOG
uniprot id: A0A2R8ZW83
uniprot id: A0A2R8ZW98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NUP188
gene id: 9597:NUP188
uniprot id: A0A2R9BL32
names: Subcellular Location Annotation
messages: nuclear pore complex

9597:LOC100972166
gene id: 9597:LOC100972166
uniprot id: A0A2R8ZUD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9597:RPE
gene id: 9597:RPE
uniprot id: A0A2R9B0Z6
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9597:LOC100971765
gene id: 9597:LOC100971765
uniprot id: A0A2R9ASP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:DRD3
gene id: 9597:DRD3
uniprot id: A0A2R9AV93
uniprot id: A0A2R9AVK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9597:RAB39B
gene id: 9597:RAB39B
uniprot id: A0A2R9C4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9597:CANT1
gene id: 9597:CANT1
uniprot id: A0A2R9AD62
names: Similarity
messages: Belongs to the apyrase family.

9597:LOC100980715
gene id: 9597:LOC100980715
uniprot id: A0A2R9AU24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CEP55
gene id: 9597:CEP55
uniprot id: A0A2R9C2I3
names: Subcellular Location Annotation
messages: Cytoplasm

9597:IRAK2
gene id: 9597:IRAK2
uniprot id: A0A2R9BPE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9597:FUCA2
gene id: 9597:FUCA2
uniprot id: A0A2R9BGD3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9597:CTBS
gene id: 9597:CTBS
uniprot id: A0A2R9C459
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

9597:TMEM123
gene id: 9597:TMEM123
uniprot id: A0A2R9CBF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9597:CSF3
gene id: 9597:CSF3
uniprot id: A0A2R8ZJQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

9597:GIMAP6
gene id: 9597:GIMAP6
uniprot id: A0A2R9AXZ2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:TP53I11
gene id: 9597:TP53I11
uniprot id: A0A2R9A4P5
names: Subcellular Location Annotation
messages: Membrane

9597:RHBDF2
gene id: 9597:RHBDF2
uniprot id: A0A2R9BTV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9597:PSMB10
gene id: 9597:PSMB10
uniprot id: A0A2R9AV10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:GALNT15
gene id: 9597:GALNT15
uniprot id: A0A2R9C5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:SLC35B3
gene id: 9597:SLC35B3
uniprot id: A0A2R9BWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9597:ZFP36
gene id: 9597:ZFP36
uniprot id: A0A2R9AM16
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9597:MBOAT4
gene id: 9597:MBOAT4
uniprot id: A0A2R9APM1
names: Subcellular Location Annotation
messages: Membrane

9597:CASP6
gene id: 9597:CASP6
uniprot id: A0A2R9BHM8
uniprot id: A0A2R9BMA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9597:USH2A
gene id: 9597:USH2A
uniprot id: A0A2R9ADY7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100980585
gene id: 9597:LOC100980585
uniprot id: A0A2R9BHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:KCNJ4
gene id: 9597:KCNJ4
uniprot id: A0A2R8ZJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:ANTXR1
gene id: 9597:ANTXR1
uniprot id: A0A2R9BPT3
uniprot id: A0A2R9BPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9597:EIF4E
gene id: 9597:EIF4E
uniprot id: A0A2R9CSB0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9597:B3GALNT2
gene id: 9597:B3GALNT2
uniprot id: A0A2R9B8J8
uniprot id: A0A2R9BEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:RPL11
gene id: 9597:RPL11
uniprot id: A0A2R9AUR7
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9597:CA1
gene id: 9597:CA1
uniprot id: A0A2R9C5D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9597:PIGS
gene id: 9597:PIGS
uniprot id: A0A2R9CGJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CFI
gene id: 9597:CFI
uniprot id: A0A2R9BVP8
uniprot id: A0A2R9BVQ4
uniprot id: A0A2R9C4V3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100992969
gene id: 9597:LOC100992969
uniprot id: A0A2R9AZ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:CCSER2
gene id: 9597:CCSER2
uniprot id: A0A2R9ADT3
uniprot id: A0A2R9AIP4
uniprot id: A0A2R9AK67
names: Similarity
messages: Belongs to the CCSER family.

9597:CXCR3
gene id: 9597:CXCR3
uniprot id: A0A2R9CB54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9597:ITM2A
gene id: 9597:ITM2A
uniprot id: A0A2R9AK87
uniprot id: A0A2R9AP45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9597:PMPCB
gene id: 9597:PMPCB
uniprot id: A0A2R9C0H2
uniprot id: A0A2R9C334
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9597:POMGNT1
gene id: 9597:POMGNT1
uniprot id: A0A2R9ADK6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9597:LOC100988783
gene id: 9597:LOC100988783
uniprot id: A0A2R9BHM1
names: Function
messages: May be involved in transcriptional regulation.

9597:CACNG5
gene id: 9597:CACNG5
uniprot id: A0A2R9C1U1
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9597:LOC100977464
gene id: 9597:LOC100977464
uniprot id: A0A2R8ZCZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RCAN3
gene id: 9597:RCAN3
uniprot id: A0A2R9AD09
names: Similarity
messages: Belongs to the RCAN family.

9597:LOC117974251
gene id: 9597:LOC117974251
uniprot id: A0A2R8ZE99
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9597:SQSTM1
gene id: 9597:SQSTM1
uniprot id: A0A2R9B442
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9597:SLC34A1
gene id: 9597:SLC34A1
uniprot id: A0A2R9AEJ9
uniprot id: A0A2R9AL66
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9597:ARFGEF2
gene id: 9597:ARFGEF2
uniprot id: A0A2R9B2G6
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9597:GPR182
gene id: 9597:GPR182
uniprot id: A0A2R8ZN22
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:NEXMIF
gene id: 9597:NEXMIF
uniprot id: A0A2R8ZFQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:ATP6V0A1
gene id: 9597:ATP6V0A1
uniprot id: A0A2R9B4D4
uniprot id: A0A2R9B4D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9597:SLC6A9
gene id: 9597:SLC6A9
uniprot id: A0A2R9CHG2
uniprot id: A0A2R9CR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9597:C16H16orf91
gene id: 9597:C16H16orf91
uniprot id: A0A2R9B3Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

9597:NUDT12
gene id: 9597:NUDT12
uniprot id: A0A2R9BGH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9597:MAN1A2
gene id: 9597:MAN1A2
uniprot id: A0A2R9A2C4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9597:ELL2
gene id: 9597:ELL2
uniprot id: A0A2R8ZKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9597:MCEE
gene id: 9597:MCEE
uniprot id: A0A2R8ZPA7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9597:MRGPRE
gene id: 9597:MRGPRE
uniprot id: A0A2R8ZF99
names: Subcellular Location Annotation
messages: Cell membrane

9597:STARD8
gene id: 9597:STARD8
uniprot id: A0A2R8ZIY8
names: Subcellular Location Annotation
messages: Cytoplasm

9597:SERPINF2
gene id: 9597:SERPINF2
uniprot id: A0A2R9BXC9
names: Similarity
messages: Belongs to the serpin family.

9597:HTN3
gene id: 9597:HTN3
uniprot id: A0A2R9AZZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9597:UROS
gene id: 9597:UROS
uniprot id: A0A2R9A8M7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9597:PAQR3
gene id: 9597:PAQR3
uniprot id: A0A2R9C4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:TMEM208
gene id: 9597:TMEM208
uniprot id: A0A2R8ZZ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9597:GBF1
gene id: 9597:GBF1
uniprot id: A0A2R9CF35
names: Subcellular Location Annotation
messages: Golgi apparatus

9597:ARSI
gene id: 9597:ARSI
uniprot id: A0A2R9BT80
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:BTAF1
gene id: 9597:BTAF1
uniprot id: A0A2R9CL47
names: Subcellular Location Annotation
messages: Nucleus

9597:RFFL
gene id: 9597:RFFL
uniprot id: A0A2R9AAH6
names: Subcellular Location Annotation
messages: Cell membrane

9597:DRD1
gene id: 9597:DRD1
uniprot id: A0A2R8ZF27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9597:SNUPN
gene id: 9597:SNUPN
uniprot id: A0A2R9AYD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9597:ADGRF1
gene id: 9597:ADGRF1
uniprot id: A0A2R8ZWS3
names: Subcellular Location Annotation
messages: Membrane

9597:EEF1B2
gene id: 9597:EEF1B2
uniprot id: A0A2R9AUS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9597:NDUFS5
gene id: 9597:NDUFS5
uniprot id: A0A2R9A979
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9597:SLC2A2
gene id: 9597:SLC2A2
uniprot id: A0A2R9BVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9597:CACNG2
gene id: 9597:CACNG2
uniprot id: A0A2R8ZR06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9597:ABHD12
gene id: 9597:ABHD12
uniprot id: A0A2R9BRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ZNF18
gene id: 9597:ZNF18
uniprot id: A0A2R9AE09
uniprot id: A0A2R9AHY7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:TNNI3
gene id: 9597:TNNI3
uniprot id: A0A2R9ATT7
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9597:CAST
gene id: 9597:CAST
uniprot id: A0A2R9CCE7
uniprot id: A0A2R9CCK9
uniprot id: A0A2R9CN40
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9597:VNN2
gene id: 9597:VNN2
uniprot id: A0A2R9AA81
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:PRPS1
gene id: 9597:PRPS1
uniprot id: A0A2R9CDT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9597:ADAM32
gene id: 9597:ADAM32
uniprot id: A0A2R9AWU9
uniprot id: A0A2R9B2Q0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TMEM198
gene id: 9597:TMEM198
uniprot id: A0A2R9A0U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9597:OSBPL2
gene id: 9597:OSBPL2
uniprot id: A0A2R8ZDQ6
names: Similarity
messages: Belongs to the OSBP family.

9597:NOG
gene id: 9597:NOG
uniprot id: A0A2R8ZAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9597:GGPS1
gene id: 9597:GGPS1
uniprot id: A0A2R9AIF6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9597:LOX
gene id: 9597:LOX
uniprot id: A0A2R9B5X9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:CDIP1
gene id: 9597:CDIP1
uniprot id: A0A2R9CDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9597:PNMT
gene id: 9597:PNMT
uniprot id: A0A2R9ARD0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9597:LOC100980404
gene id: 9597:LOC100980404
uniprot id: A0A2R9C518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9597:H1-2
gene id: 9597:H1-2
uniprot id: A0A2R8ZHX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9597:TMEM170A
gene id: 9597:TMEM170A
uniprot id: A0A2R9BCJ3
uniprot id: A0A2R9BDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9597:ATE1
gene id: 9597:ATE1
uniprot id: A0A2R9BVX0
uniprot id: A0A2R9C5M4
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9597:NHS
gene id: 9597:NHS
uniprot id: A0A2R9AJ71
uniprot id: A0A2R9ARC7
names: Similarity
messages: Belongs to the NHS family.

9597:HBEGF
gene id: 9597:HBEGF
uniprot id: A0A2R9BV62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TRAPPC3L
gene id: 9597:TRAPPC3L
uniprot id: A0A2R9CJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9597:STARD9
gene id: 9597:STARD9
uniprot id: A0A2R8Z965
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:GCAT
gene id: 9597:GCAT
uniprot id: A0A2R8ZU53
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9597:SKA2
gene id: 9597:SKA2
uniprot id: A0A2R9B8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9597:PGBD1
gene id: 9597:PGBD1
uniprot id: A0A2R9BPD9
names: Subcellular Location Annotation
messages: Nucleus

9597:DHX8
gene id: 9597:DHX8
uniprot id: A0A2R9CCJ7
names: Subcellular Location Annotation
messages: Nucleus

9597:HOXC4
gene id: 9597:HOXC4
uniprot id: A0A2R9BS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:SPG7
gene id: 9597:SPG7
uniprot id: A0A2R9AEG9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9597:GTF2E2
gene id: 9597:GTF2E2
uniprot id: A0A2R9AHX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9597:RHO
gene id: 9597:RHO
uniprot id: A0A2R9C4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9597:KIFBP
gene id: 9597:KIFBP
uniprot id: A0A2R9BSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9597:SDC2
gene id: 9597:SDC2
uniprot id: A0A2R9B337
uniprot id: A0A2R9B549
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9597:LYRM4
gene id: 9597:LYRM4
uniprot id: A0A2R9A2C0
uniprot id: A0A2R9A3H3
uniprot id: A0A2R9A6W7
names: Similarity
messages: Belongs to the complex I LYR family.

9597:FAT4
gene id: 9597:FAT4
uniprot id: A0A2R9AP84
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LDHB
gene id: 9597:LDHB
uniprot id: A0A2R9AUG7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:SEC61A1
gene id: 9597:SEC61A1
uniprot id: A0A2R8ZJ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LAMA2
gene id: 9597:LAMA2
uniprot id: A0A2R9AC71
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:ATP8B1
gene id: 9597:ATP8B1
uniprot id: A0A2R9CHA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:NOSIP
gene id: 9597:NOSIP
uniprot id: A0A2R9AWT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9597:WDR91
gene id: 9597:WDR91
uniprot id: A0A2R9CLL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:CRYAB
gene id: 9597:CRYAB
uniprot id: A0A2R9CGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9597:MINAR1
gene id: 9597:MINAR1
uniprot id: A0A2R9BXS2
names: Similarity
messages: Belongs to the MINAR family.

9597:TIMM17B
gene id: 9597:TIMM17B
uniprot id: A0A2R9BCR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9597:RIC3
gene id: 9597:RIC3
uniprot id: A0A2R9BXD8
names: Similarity
messages: Belongs to the ric-3 family.

9597:SBDS
gene id: 9597:SBDS
uniprot id: A0A2R9CL09
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9597:LIX1
gene id: 9597:LIX1
uniprot id: A0A2R9B1J2
names: Similarity
messages: Belongs to the LIX1 family.

9597:AKAP5
gene id: 9597:AKAP5
uniprot id: A0A2R8ZNQ9
names: Subcellular Location Annotation
messages: Membrane

9597:RAMP2
gene id: 9597:RAMP2
uniprot id: A0A2R9BNU3
names: Similarity
messages: Belongs to the RAMP family.

9597:HBS1L
gene id: 9597:HBS1L
uniprot id: A0A2R9A8Z6
uniprot id: A0A2R9AE88
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Interacts with the SKI complex.

9597:PCK2
gene id: 9597:PCK2
uniprot id: A0A2R9AWJ1
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9597:OST4
gene id: 9597:OST4
uniprot id: A0A2R8ZDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TNS1
gene id: 9597:TNS1
uniprot id: A0A2R9C2V5
uniprot id: A0A2R9C5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9597:URM1
gene id: 9597:URM1
uniprot id: A0A2R9AE82
uniprot id: A0A2R9AJ31
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9597:DNASE1
gene id: 9597:DNASE1
uniprot id: A0A2R9B4D1
names: Similarity
messages: Belongs to the DNase I family.

9597:CACNB4
gene id: 9597:CACNB4
uniprot id: A0A2R8ZZ38
uniprot id: A0A2R8ZZ57
uniprot id: A0A2R9A3E7
uniprot id: A0A2R9A4Q0
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9597:ZHX1
gene id: 9597:ZHX1
uniprot id: A1YG99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity).
messages: Belongs to the ZHX family.
messages: Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity).
messages: Nucleus

9597:CYP3A5
gene id: 9597:CYP3A5
uniprot id: A0A2R9BZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:SLC6A7
gene id: 9597:SLC6A7
uniprot id: A0A2R8ZDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:EARS2
gene id: 9597:EARS2
uniprot id: A0A2R8ZZ88
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9597:ERAP2
gene id: 9597:ERAP2
uniprot id: A0A2R9A7J6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:DSTN
gene id: 9597:DSTN
uniprot id: A0A2R9CF75
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9597:MARK1
gene id: 9597:MARK1
uniprot id: A0A2R9B216
uniprot id: A0A2R9B5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:LOC100991582
gene id: 9597:LOC100991582
uniprot id: A0A2R8Z930
uniprot id: A0A2R8ZA15
names: Similarity
messages: Belongs to the SMIM12 family.

9597:CDH3
gene id: 9597:CDH3
uniprot id: A0A2R9BYH8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:PTPRB
gene id: 9597:PTPRB
uniprot id: A0A2R9C722
uniprot id: A0A2R9C9S7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9597:CLEC16A
gene id: 9597:CLEC16A
uniprot id: A0A2R9BXE4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9597:C5
gene id: 9597:C5
uniprot id: A0A2R9APR4
names: Subcellular Location Annotation
messages: Secreted

9597:SLITRK5
gene id: 9597:SLITRK5
uniprot id: A0A2R8ZM48
names: Similarity
messages: Belongs to the SLITRK family.

9597:NDOR1
gene id: 9597:NDOR1
uniprot id: A0A2R9BP41
uniprot id: A0A2R9BP43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

9597:PAFAH1B1
gene id: 9597:PAFAH1B1
uniprot id: A0A2R9A5C1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9597:GPC4
gene id: 9597:GPC4
uniprot id: A0A2R9BDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9597:PKD1L3
gene id: 9597:PKD1L3
uniprot id: A0A2R9A437
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TANGO6
gene id: 9597:TANGO6
uniprot id: A0A2R9C531
names: Similarity
messages: Belongs to the Tango6 family.

9597:CASP14
gene id: 9597:CASP14
uniprot id: A0A2R9A9W3
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:PPP1R10
gene id: 9597:PPP1R10
uniprot id: A0A2R9BPN9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9597:GGCX
gene id: 9597:GGCX
uniprot id: A0A2R9AHA6
uniprot id: A0A2R9AL65
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9597:SYT1
gene id: 9597:SYT1
uniprot id: A0A2R9A4D0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9597:ZNF776
gene id: 9597:ZNF776
uniprot id: A0A2R8ZSR4
names: Function
messages: May be involved in transcriptional regulation.

9597:STX11
gene id: 9597:STX11
uniprot id: A0A2R8ZCY5
names: Similarity
messages: Belongs to the syntaxin family.

9597:ASB7
gene id: 9597:ASB7
uniprot id: A0A2R9BHT5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:NRP2
gene id: 9597:NRP2
uniprot id: A0A2R9C4B1
uniprot id: A0A2R9C6T9
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SLC24A5
gene id: 9597:SLC24A5
uniprot id: A0A2R9C9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9597:TYK2
gene id: 9597:TYK2
uniprot id: A0A2R9C1D6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9597:OXCT2
gene id: 9597:OXCT2
uniprot id: A0A2R8ZDZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9597:SLC10A1
gene id: 9597:SLC10A1
uniprot id: A0A2R9AN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:CD3G
gene id: 9597:CD3G
uniprot id: A0A2R8ZVB5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9597:FAM114A1
gene id: 9597:FAM114A1
uniprot id: A0A2R9BYV1
names: Similarity
messages: Belongs to the FAM114 family.

9597:VDAC1
gene id: 9597:VDAC1
uniprot id: A0A2R9BFY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9597:LYPD6
gene id: 9597:LYPD6
uniprot id: A0A2R9CH19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:COG7
gene id: 9597:COG7
uniprot id: A0A2R9BJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:LOC100973061
gene id: 9597:LOC100973061
uniprot id: A0A2R9CIL5
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9597:RUVBL2
gene id: 9597:RUVBL2
uniprot id: A0A2R9BQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9597:IAPP
gene id: 9597:IAPP
uniprot id: A0A2R9ATQ5
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9597:CTPS1
gene id: 9597:CTPS1
uniprot id: A0A2R9A533
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9597:DCTN6
gene id: 9597:DCTN6
uniprot id: A0A2R9BDS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9597:ATP5MC1
gene id: 9597:ATP5MC1
uniprot id: A0A2R9C6Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9597:STARD6
gene id: 9597:STARD6
uniprot id: A0A2R9ABZ8
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9597:ITPK1
gene id: 9597:ITPK1
uniprot id: A0A2R9BE27
uniprot id: A0A2R9BHY4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
messages: Monomer.

9597:MICALL2
gene id: 9597:MICALL2
uniprot id: A0A2R8ZU41
names: Subcellular Location Annotation
messages: Membrane

9597:VPS37A
gene id: 9597:VPS37A
uniprot id: A0A2R9B4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:THOC5
gene id: 9597:THOC5
uniprot id: A0A2R9BRG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9597:ZW10
gene id: 9597:ZW10
uniprot id: A0A2R9AI36
uniprot id: A0A2R9ALY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9597:XIAP
gene id: 9597:XIAP
uniprot id: A0A2R9A858
names: Similarity
messages: Belongs to the IAP family.

9597:KCNK1
gene id: 9597:KCNK1
uniprot id: A0A2R9ACF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9597:SMARCAD1
gene id: 9597:SMARCAD1
uniprot id: A0A2R9B6H0
names: Subcellular Location Annotation
messages: Chromosome

9597:FSCN3
gene id: 9597:FSCN3
uniprot id: A0A2R9CGH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9597:COPE
gene id: 9597:COPE
uniprot id: A0A2R8ZM06
uniprot id: A0A2R8ZQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9597:ERN1
gene id: 9597:ERN1
uniprot id: A0A2R9AFY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:GABRB2
gene id: 9597:GABRB2
uniprot id: A0A2R9C809
uniprot id: A0A2R9C8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:TOP1
gene id: 9597:TOP1
uniprot id: A0A2R9CGT5
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9597:PPP2R2D
gene id: 9597:PPP2R2D
uniprot id: A0A2R8ZJJ0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:TRPM4
gene id: 9597:TRPM4
uniprot id: A0A2R9AII9
names: Subcellular Location Annotation
messages: Membrane

9597:DUSP7
gene id: 9597:DUSP7
uniprot id: A0A2R9CJY9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9597:ARL14
gene id: 9597:ARL14
uniprot id: A0A2R8ZGM7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:LRRC8E
gene id: 9597:LRRC8E
uniprot id: A0A2R9BKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9597:LOC100974684
gene id: 9597:LOC100974684
uniprot id: A0A2R8ZIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100978244
gene id: 9597:LOC100978244
uniprot id: A0A2R8ZEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:OSGEP
gene id: 9597:OSGEP
uniprot id: A0A2R8ZJ76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9597:HAS2
gene id: 9597:HAS2
uniprot id: A0A2R9AEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9597:NOP10
gene id: 9597:NOP10
uniprot id: A0A2R9B7C3
names: Similarity
messages: Belongs to the NOP10 family.

9597:SLC44A2
gene id: 9597:SLC44A2
uniprot id: A0A2R9BUX2
uniprot id: A0A2R9BYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9597:HSF2
gene id: 9597:HSF2
uniprot id: A0A2R9B097
uniprot id: A0A2R9B0A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9597:PNKD
gene id: 9597:PNKD
uniprot id: A0A2R9B600
uniprot id: A0A2R9B8M0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9597:TMEM19
gene id: 9597:TMEM19
uniprot id: A0A2R9B6R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9597:PAX7
gene id: 9597:PAX7
uniprot id: A0A2R9AC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:GABRG1
gene id: 9597:GABRG1
uniprot id: A0A2R9A1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:PUS7L
gene id: 9597:PUS7L
uniprot id: A0A2R9CDC6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9597:KIF2B
gene id: 9597:KIF2B
uniprot id: A0A2R8ZER8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:PNRC1
gene id: 9597:PNRC1
uniprot id: A0A2R9C2P9
names: Subcellular Location Annotation
messages: Nucleus

9597:DOCK9
gene id: 9597:DOCK9
uniprot id: A0A2R9B815
names: Similarity
messages: Belongs to the DOCK family.

9597:UBAC2
gene id: 9597:UBAC2
uniprot id: A0A2R9A3K3
names: Subcellular Location Annotation
messages: Membrane

9597:ASPN
gene id: 9597:ASPN
uniprot id: A0A2R9B818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9597:RTF2
gene id: 9597:RTF2
uniprot id: A0A2R8ZSA9
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9597:MMD
gene id: 9597:MMD
uniprot id: A0A2R9C4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:TSHZ1
gene id: 9597:TSHZ1
uniprot id: A0A2R9AAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9597:MLF2
gene id: 9597:MLF2
uniprot id: A0A2R9B1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9597:HOXA9
gene id: 9597:HOXA9
uniprot id: A0A2R9A8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9597:SERPINB8
gene id: 9597:SERPINB8
uniprot id: A0A2R9AD47
names: Similarity
messages: Belongs to the serpin family.

9597:ZFHX2
gene id: 9597:ZFHX2
uniprot id: A0A2R9BVA3
names: Subcellular Location Annotation
messages: Nucleus

9597:BCL2L10
gene id: 9597:BCL2L10
uniprot id: A0A2R9BCD9
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:CTSK
gene id: 9597:CTSK
uniprot id: A0A2R9C710
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9597:SMC5
gene id: 9597:SMC5
uniprot id: A0A2R8ZBS8
uniprot id: A0A2R8ZFB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9597:SULT1E1
gene id: 9597:SULT1E1
uniprot id: A0A2R8ZSI9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:PLCB1
gene id: 9597:PLCB1
uniprot id: A0A2R8ZKZ8
uniprot id: A0A2R8ZNS9
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9597:PTPN12
gene id: 9597:PTPN12
uniprot id: A0A2R9A8Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9597:JRK
gene id: 9597:JRK
uniprot id: A0A2R9BMH4
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100972584
gene id: 9597:LOC100972584
uniprot id: A0A2R8Z6F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:COQ8B
gene id: 9597:COQ8B
uniprot id: A0A2R9ANL3
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:SRXN1
gene id: 9597:SRXN1
uniprot id: A0A2R9AHS2
names: Similarity
messages: Belongs to the sulfiredoxin family.

9597:MTRNR2L4
gene id: 9597:MTRNR2L4
uniprot id: A0A2R9AXJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9597:PHOSPHO2
gene id: 9597:PHOSPHO2
uniprot id: A0A2R8ZP24
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9597:ZNF317
gene id: 9597:ZNF317
uniprot id: A0A2R9B2Z8
uniprot id: A0A2R9B303
names: Function
messages: May be involved in transcriptional regulation.

9597:GOSR1
gene id: 9597:GOSR1
uniprot id: A0A2R9AEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9597:TAS2R4
gene id: 9597:TAS2R4
uniprot id: Q646D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.
messages: cilium membrane

9597:RIPPLY1
gene id: 9597:RIPPLY1
uniprot id: A0A2R9BR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9597:UCP2
gene id: 9597:UCP2
uniprot id: A0A2R8Z8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:USP48
gene id: 9597:USP48
uniprot id: A0A2R9A2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9597:KCNJ14
gene id: 9597:KCNJ14
uniprot id: A0A2R9A2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:LOC100995302
gene id: 9597:LOC100995302
uniprot id: A0A2R9BNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9597:CUL3
gene id: 9597:CUL3
uniprot id: A0A2R9A568
names: Similarity
messages: Belongs to the cullin family.

9597:TRAPPC2
gene id: 9597:TRAPPC2
uniprot id: A0A2R9BQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9597:PIR
gene id: 9597:PIR
uniprot id: A0A2R9A827
names: Similarity
messages: Belongs to the pirin family.

9597:VCAN
gene id: 9597:VCAN
uniprot id: A0A2R8ZPX8
uniprot id: A0A2R8ZPY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:SLC2A4
gene id: 9597:SLC2A4
uniprot id: A0A2R8Z846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9597:LDHA
gene id: 9597:LDHA
uniprot id: A0A2R9CIK4
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:SLCO1B1
gene id: 9597:SLCO1B1
uniprot id: A0A2R9AN29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:DLK2
gene id: 9597:DLK2
uniprot id: A0A2R8ZUJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PPAT
gene id: 9597:PPAT
uniprot id: A0A2R9C821
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9597:CD3E
gene id: 9597:CD3E
uniprot id: A0A2R9AJG0
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100971602
gene id: 9597:LOC100971602
uniprot id: A0A2R9AXC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:PSMD11
gene id: 9597:PSMD11
uniprot id: A0A2R9CMB9
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9597:NDUFA7
gene id: 9597:NDUFA7
uniprot id: A0A2R9CL51
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9597:DSG4
gene id: 9597:DSG4
uniprot id: A0A2R9C3N0
uniprot id: A0A2R9C6L3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:KDR
gene id: 9597:KDR
uniprot id: A0A2R9CED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:DIPK1A
gene id: 9597:DIPK1A
uniprot id: A0A2R9CNM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9597:E2F7
gene id: 9597:E2F7
uniprot id: A0A2R8Z7E6
uniprot id: A0A2R8ZDR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:NRXN3
gene id: 9597:NRXN3
uniprot id: A0A2R9ALZ5
uniprot id: A0A2R9AML2
uniprot id: A0A2R9ARK2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TMEM230
gene id: 9597:TMEM230
uniprot id: A0A2R9AAV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9597:HK1
gene id: 9597:HK1
uniprot id: A0A2R9C115
uniprot id: A0A2R9C7F8
names: Similarity
messages: Belongs to the hexokinase family.

9597:SERPINC1
gene id: 9597:SERPINC1
uniprot id: A0A2R9CFX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9597:ARG2
gene id: 9597:ARG2
uniprot id: A0A2R9CNG5
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9597:DNTT
gene id: 9597:DNTT
uniprot id: A0A2R9C288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9597:NOP2
gene id: 9597:NOP2
uniprot id: A0A2R9ABG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9597:PRDX1
gene id: 9597:PRDX1
uniprot id: A0A2R8Z6R9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9597:CER1
gene id: 9597:CER1
uniprot id: A0A2R9BLX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:CDKL1
gene id: 9597:CDKL1
uniprot id: A0A2R9C4D6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:PI4K2B
gene id: 9597:PI4K2B
uniprot id: A0A2R9C0R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9597:DHRS7C
gene id: 9597:DHRS7C
uniprot id: A0A2R9A4E4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:RARRES2
gene id: 9597:RARRES2
uniprot id: A0A2R9CGZ5
names: Subcellular Location Annotation
messages: Secreted

9597:RPL7
gene id: 9597:RPL7
uniprot id: A0A2R9BEJ4
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9597:C9H9orf64
gene id: 9597:C9H9orf64
uniprot id: A0A2R8ZZH7
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9597:PADI2
gene id: 9597:PADI2
uniprot id: A0A2R9BZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9597:GLRA2
gene id: 9597:GLRA2
uniprot id: A0A2R9AUZ5
uniprot id: A0A2R9B148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9597:PDCD4
gene id: 9597:PDCD4
uniprot id: A0A2R9C3Z6
names: Similarity
messages: Belongs to the PDCD4 family.

9597:CDH8
gene id: 9597:CDH8
uniprot id: A0A2R9B5D6
names: Subcellular Location Annotation
messages: Membrane

9597:TRAF1
gene id: 9597:TRAF1
uniprot id: A0A2R9C863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9597:COQ9
gene id: 9597:COQ9
uniprot id: A0A2R8ZFF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9597:GCFC2
gene id: 9597:GCFC2
uniprot id: A0A2R9C7L6
names: Similarity
messages: Belongs to the GCF family.

9597:SMIM12
gene id: 9597:SMIM12
uniprot id: A0A2R8Z930
uniprot id: A0A2R8ZA15
names: Similarity
messages: Belongs to the SMIM12 family.

9597:PF4
gene id: 9597:PF4
uniprot id: A0A2R9BF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:NME5
gene id: 9597:NME5
uniprot id: A0A2R9ADE6
names: Similarity
messages: Belongs to the NDK family.

9597:CCKAR
gene id: 9597:CCKAR
uniprot id: A0A2R8ZVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9597:CUTA
gene id: 9597:CUTA
uniprot id: A0A2R9BHL2
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9597:DEGS1
gene id: 9597:DEGS1
uniprot id: A0A2R9AT49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

9597:DPH2
gene id: 9597:DPH2
uniprot id: A0A2R9BW78
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9597:EEF1AKMT3
gene id: 9597:EEF1AKMT3
uniprot id: A0A2R9CI70
uniprot id: A0A2R9CI74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9597:BLMH
gene id: 9597:BLMH
uniprot id: A0A2R9B0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9597:TFCP2
gene id: 9597:TFCP2
uniprot id: A0A2R8ZHD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9597:FBXO32
gene id: 9597:FBXO32
uniprot id: A0A2R8ZCU0
names: Subcellular Location Annotation
messages: Nucleus

9597:GAL3ST1
gene id: 9597:GAL3ST1
uniprot id: A0A2R9B778
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9597:RBM10
gene id: 9597:RBM10
uniprot id: A0A2R9C265
names: Subcellular Location Annotation
messages: Nucleus

9597:EGFL8
gene id: 9597:EGFL8
uniprot id: A0A2R9CS31
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:AQP1
gene id: 9597:AQP1
uniprot id: A0A2R9B319
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

9597:LOC100974972
gene id: 9597:LOC100974972
uniprot id: A0A2R8ZGF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:BCAR1
gene id: 9597:BCAR1
uniprot id: A0A2R9AR95
uniprot id: A0A2R9AXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9597:RASGRP3
gene id: 9597:RASGRP3
uniprot id: A0A2R9B2S9
names: Similarity
messages: Belongs to the RASGRP family.

9597:C5AR2
gene id: 9597:C5AR2
uniprot id: A0A2R8ZS57
names: Subcellular Location Annotation
messages: Cell membrane

9597:PRKAB2
gene id: 9597:PRKAB2
uniprot id: A0A2R9BAT5
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9597:RAB27A
gene id: 9597:RAB27A
uniprot id: A0A2R9ACB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9597:GDPGP1
gene id: 9597:GDPGP1
uniprot id: A0A2R8ZDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9597:OTX2
gene id: 9597:OTX2
uniprot id: A0A2R9CE23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9597:HCAR3
gene id: 9597:HCAR3
uniprot id: A0A2R8ZLY5
uniprot id: A0A4Y1JWN7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:FAM53B
gene id: 9597:FAM53B
uniprot id: A0A2R8ZVX0
names: Similarity
messages: Belongs to the FAM53 family.

9597:PEX2
gene id: 9597:PEX2
uniprot id: A0A2R9ARI5
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9597:PITPNM3
gene id: 9597:PITPNM3
uniprot id: A0A2R8ZX56
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9597:CCNJL
gene id: 9597:CCNJL
uniprot id: A0A2R9BYM4
names: Similarity
messages: Belongs to the cyclin family.

9597:DHRS7
gene id: 9597:DHRS7
uniprot id: A0A2R8ZPB8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:TNP1
gene id: 9597:TNP1
uniprot id: A0A2R8ZQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9597:MKX
gene id: 9597:MKX
uniprot id: A0A2R9C923
names: Subcellular Location Annotation
messages: Nucleus

9597:OSM
gene id: 9597:OSM
uniprot id: A0A2R9A1R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

9597:INCENP
gene id: 9597:INCENP
uniprot id: A0A2R8ZJ05
uniprot id: A0A2R8ZJU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9597:TSPAN19
gene id: 9597:TSPAN19
uniprot id: A0A2R9CAP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LOC100984482
gene id: 9597:LOC100984482
uniprot id: A0A2R9BFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

9597:HTR7
gene id: 9597:HTR7
uniprot id: A0A2R9C3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:IRX1
gene id: 9597:IRX1
uniprot id: A0A2R9BLD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9597:HDHD3
gene id: 9597:HDHD3
uniprot id: A0A2R8ZBN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9597:RDH11
gene id: 9597:RDH11
uniprot id: A0A2R9BIG4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:CDC20
gene id: 9597:CDC20
uniprot id: A0A2R9AFL6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9597:SF3B5
gene id: 9597:SF3B5
uniprot id: A0A2R8ZDC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9597:VARS2
gene id: 9597:VARS2
uniprot id: A0A2R9CFL7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:SLC26A6
gene id: 9597:SLC26A6
uniprot id: A0A2R8ZWF2
uniprot id: A0A2R8ZXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane

9597:ZNF277
gene id: 9597:ZNF277
uniprot id: A0A2R9ACZ1
names: Similarity
messages: Belongs to the ZNF277 family.

9597:TOR1B
gene id: 9597:TOR1B
uniprot id: A0A2R9ADY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9597:POMK
gene id: 9597:POMK
uniprot id: A0A2R9BAA0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

9597:CLASP1
gene id: 9597:CLASP1
uniprot id: A0A2R9CGU7
uniprot id: A0A2R9CJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

9597:ZCCHC17
gene id: 9597:ZCCHC17
uniprot id: A0A2R9AKQ1
uniprot id: A0A2R9AKS3
names: Subcellular Location Annotation
messages: nucleolus

9597:CSGALNACT2
gene id: 9597:CSGALNACT2
uniprot id: A0A2R9C3Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:RITA1
gene id: 9597:RITA1
uniprot id: A0A2R9A207
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9597:NAAA
gene id: 9597:NAAA
uniprot id: A0A2R9C7X5
uniprot id: A0A2R9CFJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9597:SIX2
gene id: 9597:SIX2
uniprot id: A0A2R9BZP5
names: Subcellular Location Annotation
messages: Nucleus

9597:ETS1
gene id: 9597:ETS1
uniprot id: A0A2R8ZVE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9597:MCOLN1
gene id: 9597:MCOLN1
uniprot id: A0A2R9B983
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9597:UROD
gene id: 9597:UROD
uniprot id: A0A2R9B7D3
uniprot id: A0A2R9BB53
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9597:INA
gene id: 9597:INA
uniprot id: A0A2R9BN98
names: Similarity
messages: Belongs to the intermediate filament family.

9597:HEPHL1
gene id: 9597:HEPHL1
uniprot id: A0A2R9BXI6
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:GPR87
gene id: 9597:GPR87
uniprot id: A0A2R9BZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:ATP5F1B
gene id: 9597:ATP5F1B
uniprot id: A0A2R9BG76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9597:UBE2E2
gene id: 9597:UBE2E2
uniprot id: A0A2R9AB22
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:HTR2A
gene id: 9597:HTR2A
uniprot id: A0A2R8Z5S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9597:TEX13A
gene id: 9597:TEX13A
uniprot id: A0A2R9CLL4
names: Similarity
messages: Belongs to the TEX13 family.

9597:KAT7
gene id: 9597:KAT7
uniprot id: A0A2R9C4N7
uniprot id: A0A2R9CER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9597:ZNF229
gene id: 9597:ZNF229
uniprot id: A0A2R9B887
names: Function
messages: May be involved in transcriptional regulation.

9597:GRAMD1C
gene id: 9597:GRAMD1C
uniprot id: A0A2R9CQY7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:IL5
gene id: 9597:IL5
uniprot id: A0A2R9CIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9597:CLN8
gene id: 9597:CLN8
uniprot id: A0A2R9BYT9
names: Subcellular Location Annotation
messages: Membrane

9597:RAPSN
gene id: 9597:RAPSN
uniprot id: A0A2R9CCI0
uniprot id: A0A2R9CCI6
names: Similarity
messages: Belongs to the RAPsyn family.

9597:ZCCHC4
gene id: 9597:ZCCHC4
uniprot id: A0A2R9AF87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9597:ACTN3
gene id: 9597:ACTN3
uniprot id: A0A2R8ZKX8
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:GPT2
gene id: 9597:GPT2
uniprot id: A0A2R9BCX8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9597:ATP5PF
gene id: 9597:ATP5PF
uniprot id: A0A2R9B379
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9597:CA2
gene id: 9597:CA2
uniprot id: A0A2R9ATI3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9597:DNAJC18
gene id: 9597:DNAJC18
uniprot id: A0A2R9ABN6
names: Subcellular Location Annotation
messages: Membrane

9597:CLDN1
gene id: 9597:CLDN1
uniprot id: A0A2R9B835
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:PDE9A
gene id: 9597:PDE9A
uniprot id: A0A2R8ZW91
uniprot id: A0A2R8ZYF4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:BCAP29
gene id: 9597:BCAP29
uniprot id: A0A2R9CIC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9597:IGFL4
gene id: 9597:IGFL4
uniprot id: A0A2R9C246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9597:DPRX
gene id: 9597:DPRX
uniprot id: A0A2R9CKC3
names: Subcellular Location Annotation
messages: Nucleus

9597:SMC2
gene id: 9597:SMC2
uniprot id: A0A2R8ZCC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9597:ICAM3
gene id: 9597:ICAM3
uniprot id: A0A2R9CDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9597:BEX4
gene id: 9597:BEX4
uniprot id: A0A2R8Z8F7
names: Similarity
messages: Belongs to the BEX family.

9597:USE1
gene id: 9597:USE1
uniprot id: A0A2R9A2D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RC3H2
gene id: 9597:RC3H2
uniprot id: A0A2R9B867
names: Subcellular Location Annotation
messages: P-body

9597:LOC100991181
gene id: 9597:LOC100991181
uniprot id: A0A2R8ZRL0
names: Subcellular Location Annotation
messages: Membrane

9597:TAS2R10
gene id: 9597:TAS2R10
uniprot id: Q646D7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:ADCY8
gene id: 9597:ADCY8
uniprot id: A0A2R9BI25
uniprot id: A0A2R9BKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9597:LOC100992836
gene id: 9597:LOC100992836
uniprot id: A0A2R9AQ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CRABP2
gene id: 9597:CRABP2
uniprot id: A0A2R8ZYS2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:DSC2
gene id: 9597:DSC2
uniprot id: A0A2R9BB52
uniprot id: A0A2R9BEU8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:IL26
gene id: 9597:IL26
uniprot id: A0A2R9ADA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9597:DDX43
gene id: 9597:DDX43
uniprot id: A0A2R9AXQ3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:AVPR2
gene id: 9597:AVPR2
uniprot id: A0A2R9B7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

9597:NBN
gene id: 9597:NBN
uniprot id: A0A2R8ZPC7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9597:HBE1
gene id: 9597:HBE1
uniprot id: A0A2R9BP35
names: Similarity
messages: Belongs to the globin family.

9597:TINAG
gene id: 9597:TINAG
uniprot id: A0A2R9AH55
names: Similarity
messages: Belongs to the peptidase C1 family.

9597:KCNK16
gene id: 9597:KCNK16
uniprot id: A0A2R9CJT6
uniprot id: A0A2R9CJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:BZW1
gene id: 9597:BZW1
uniprot id: A0A2R9A2I6
names: Similarity
messages: Belongs to the BZW family.

9597:RFX2
gene id: 9597:RFX2
uniprot id: A0A2R9CBT6
uniprot id: A0A2R9CJS5
names: Subcellular Location Annotation
messages: Nucleus

9597:EMC8
gene id: 9597:EMC8
uniprot id: A0A2R9CBP9
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9597:DDX55
gene id: 9597:DDX55
uniprot id: A0A2R8Z8Y8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:POLR1B
gene id: 9597:POLR1B
uniprot id: A0A2R8ZDU5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9597:RGS14
gene id: 9597:RGS14
uniprot id: A0A2R9AP20
names: Subcellular Location Annotation
messages: dendrite

9597:SMARCA1
gene id: 9597:SMARCA1
uniprot id: A0A2R9B0H8
uniprot id: A0A2R9B6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9597:CYP11A1
gene id: 9597:CYP11A1
uniprot id: A0A2R9AUS6
uniprot id: A0A2R9AYY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9597:GOLM2
gene id: 9597:GOLM2
uniprot id: A0A2R8ZY29
uniprot id: A0A2R9A2I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9597:CXCR5
gene id: 9597:CXCR5
uniprot id: A0A2R9B3P4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:IL2
gene id: 9597:IL2
uniprot id: A0A2R9ACE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9597:PRDM4
gene id: 9597:PRDM4
uniprot id: A0A2R9BMW8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9597:SLC27A5
gene id: 9597:SLC27A5
uniprot id: A0A2R9C256
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:MKNK2
gene id: 9597:MKNK2
uniprot id: A0A2R9C7J3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:SLC45A3
gene id: 9597:SLC45A3
uniprot id: A0A2R9CC87
names: Subcellular Location Annotation
messages: Membrane

9597:RELL1
gene id: 9597:RELL1
uniprot id: A0A2R9AH43
names: Similarity
messages: Belongs to the RELT family.

9597:MRPS14
gene id: 9597:MRPS14
uniprot id: A0A2R9ABE5
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9597:PLA2G15
gene id: 9597:PLA2G15
uniprot id: A0A2R9CBJ6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:ERGIC3
gene id: 9597:ERGIC3
uniprot id: A0A2R9BEJ5
uniprot id: A0A2R9BN15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9597:ZNF625
gene id: 9597:ZNF625
uniprot id: A0A2R9BZ24
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100982404
gene id: 9597:LOC100982404
uniprot id: A0A2R9C0J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9597:HENMT1
gene id: 9597:HENMT1
uniprot id: A0A2R8ZWD2
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9597:TCN1
gene id: 9597:TCN1
uniprot id: A0A2R9CAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9597:GMPPB
gene id: 9597:GMPPB
uniprot id: A0A2R9ANZ8
uniprot id: A0A2R9ATG2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9597:LOC100981745
gene id: 9597:LOC100981745
uniprot id: A0A2R8ZHG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9597:ARL6IP4
gene id: 9597:ARL6IP4
uniprot id: A0A2R9A6S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9597:LOC103783663
gene id: 9597:LOC103783663
uniprot id: A0A2R8ZA07
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:PIGU
gene id: 9597:PIGU
uniprot id: A0A2R9BEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:POLR1E
gene id: 9597:POLR1E
uniprot id: A0A2R9AZN3
uniprot id: A0A2R9B0X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9597:PITX2
gene id: 9597:PITX2
uniprot id: A0A2R9C2F5
uniprot id: A0A2R9CCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9597:SRFBP1
gene id: 9597:SRFBP1
uniprot id: A0A2R9B8L8
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9597:ZNF425
gene id: 9597:ZNF425
uniprot id: A0A2R9CAB5
names: Function
messages: May be involved in transcriptional regulation.

9597:CAV3
gene id: 9597:CAV3
uniprot id: A0A2R9C7C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

9597:HSD17B4
gene id: 9597:HSD17B4
uniprot id: A0A2R9C8G1
uniprot id: A0A2R9CB89
names: Subcellular Location Annotation
messages: Peroxisome

9597:NCDN
gene id: 9597:NCDN
uniprot id: A0A2R9BZC2
uniprot id: A0A2R9C2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9597:LAMTOR4
gene id: 9597:LAMTOR4
uniprot id: A0A2R9BJ39
names: Similarity
messages: Belongs to the LAMTOR4 family.

9597:CTBP1
gene id: 9597:CTBP1
uniprot id: A0A2R9AQ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9597:NPPB
gene id: 9597:NPPB
uniprot id: A0A2R8ZZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9597:TSPYL4
gene id: 9597:TSPYL4
uniprot id: A0A2R8ZPA6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:ZNF841
gene id: 9597:ZNF841
uniprot id: A0A2R9AGT5
names: Function
messages: May be involved in transcriptional regulation.

9597:STK17B
gene id: 9597:STK17B
uniprot id: A0A2R8ZLI1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TMEM35B
gene id: 9597:TMEM35B
uniprot id: A0A2R8ZD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9597:FUT8
gene id: 9597:FUT8
uniprot id: A0A2R8ZTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9597:HEXB
gene id: 9597:HEXB
uniprot id: A0A2R9CF26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9597:ATF1
gene id: 9597:ATF1
uniprot id: A0A2R9BP84
names: Subcellular Location Annotation
messages: Nucleus

9597:ITPA
gene id: 9597:ITPA
uniprot id: A0A2R9B6B8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9597:TIMP1
gene id: 9597:TIMP1
uniprot id: A0A2R9A894
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9597:TAS2R3
gene id: 9597:TAS2R3
uniprot id: Q646D2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9597:NEK9
gene id: 9597:NEK9
uniprot id: A0A2R8ZH82
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9597:SLC6A12
gene id: 9597:SLC6A12
uniprot id: A0A2R8Z8I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

9597:MTO1
gene id: 9597:MTO1
uniprot id: A0A2R9A193
uniprot id: A0A2R9A5L3
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9597:PKIB
gene id: 9597:PKIB
uniprot id: A0A2R9C8U5
uniprot id: A0A2R9CJI2
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:GDI2
gene id: 9597:GDI2
uniprot id: A0A2R9A110
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9597:TIMELESS
gene id: 9597:TIMELESS
uniprot id: A0A2R9BBH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9597:TAGLN
gene id: 9597:TAGLN
uniprot id: A0A2R9CFE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9597:EWSR1
gene id: 9597:EWSR1
uniprot id: A0A2R9ARH0
uniprot id: A0A2R9AXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9597:SURF6
gene id: 9597:SURF6
uniprot id: A0A2R9ARF2
names: Similarity
messages: Belongs to the SURF6 family.

9597:IFT20
gene id: 9597:IFT20
uniprot id: A0A2R8ZB42
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9597:EXTL3
gene id: 9597:EXTL3
uniprot id: A0A2R9AY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:KEAP1
gene id: 9597:KEAP1
uniprot id: A0A2R9BRR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100984974
gene id: 9597:LOC100984974
uniprot id: A0A2R9BHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9597:IL15
gene id: 9597:IL15
uniprot id: A0A2R9CIL2
uniprot id: A0A2R9CIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9597:MAP3K7
gene id: 9597:MAP3K7
uniprot id: A0A2R8ZW71
uniprot id: A0A2R8ZZW1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9597:SLC39A10
gene id: 9597:SLC39A10
uniprot id: A0A2R9CCD6
names: Subcellular Location Annotation
messages: Membrane

9597:SLC66A3
gene id: 9597:SLC66A3
uniprot id: A0A2R8ZUE9
uniprot id: A0A2R8ZX30
names: Subcellular Location Annotation
messages: Membrane

9597:DBNDD2
gene id: 9597:DBNDD2
uniprot id: A0A2R9BLB3
uniprot id: A0A2R9BV41
uniprot id: A0A2R9BV46
names: Similarity
messages: Belongs to the dysbindin family.

9597:PIGN
gene id: 9597:PIGN
uniprot id: A0A2R9BVL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:EPO
gene id: 9597:EPO
uniprot id: A0A2R9CD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9597:MVK
gene id: 9597:MVK
uniprot id: A0A2R9CBP3
uniprot id: A0A2R9CMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9597:BEST3
gene id: 9597:BEST3
uniprot id: A0A2R9B2W6
uniprot id: A0A2R9B2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:SLAIN1
gene id: 9597:SLAIN1
uniprot id: A0A2R9C8M5
uniprot id: A0A2R9C8X7
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9597:SULT2A1
gene id: 9597:SULT2A1
uniprot id: A0A2R9C5R7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:ORC2
gene id: 9597:ORC2
uniprot id: A0A2R9AA19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9597:TBL1XR1
gene id: 9597:TBL1XR1
uniprot id: A0A2R9CPA2
names: Similarity
messages: Belongs to the WD repeat EBI family.

9597:ACTL8
gene id: 9597:ACTL8
uniprot id: A0A2R9AUX3
names: Similarity
messages: Belongs to the actin family.

9597:DOK4
gene id: 9597:DOK4
uniprot id: A0A2R9AY35
uniprot id: A0A2R9B3V0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9597:TTC21B
gene id: 9597:TTC21B
uniprot id: A0A2R9BJI3
names: Similarity
messages: Belongs to the TTC21 family.

9597:CARMIL3
gene id: 9597:CARMIL3
uniprot id: A0A2R9BAR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9597:GAST
gene id: 9597:GAST
uniprot id: A0A2R9AFI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9597:PSMB11
gene id: 9597:PSMB11
uniprot id: A0A2R8Z8M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:C20H20orf27
gene id: 9597:C20H20orf27
uniprot id: A0A2R9B4I8
names: Similarity
messages: Belongs to the UPF0687 family.

9597:EMP2
gene id: 9597:EMP2
uniprot id: A0A2R8ZMQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9597:ENTPD8
gene id: 9597:ENTPD8
uniprot id: A0A2R8ZU48
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:IP6K3
gene id: 9597:IP6K3
uniprot id: A0A2R9ALD0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9597:CDK5RAP3
gene id: 9597:CDK5RAP3
uniprot id: A0A2R9A907
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9597:DUSP4
gene id: 9597:DUSP4
uniprot id: A0A2R9BJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9597:CLCN5
gene id: 9597:CLCN5
uniprot id: A0A2R9A9A7
uniprot id: A0A2R9AD48
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HAL
gene id: 9597:HAL
uniprot id: A0A2R8Z7Z2
names: Similarity
messages: Belongs to the PAL/histidase family.

9597:NAPB
gene id: 9597:NAPB
uniprot id: A0A2R9CL04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9597:PDC
gene id: 9597:PDC
uniprot id: A0A2R9CQM8
names: Similarity
messages: Belongs to the phosducin family.

9597:FAM3B
gene id: 9597:FAM3B
uniprot id: A0A2R9AB58
uniprot id: A0A2R9AGR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:THBS2
gene id: 9597:THBS2
uniprot id: A0A2R9C0U2
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:UBA5
gene id: 9597:UBA5
uniprot id: A0A2R8ZX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9597:CPSF4L
gene id: 9597:CPSF4L
uniprot id: A0A2R9BE04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9597:RPL13A
gene id: 9597:RPL13A
uniprot id: A0A2R9BPU7
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9597:TEFM
gene id: 9597:TEFM
uniprot id: A0A2R9BX78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9597:RSBN1L
gene id: 9597:RSBN1L
uniprot id: A0A2R9AC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9597:ZNF548
gene id: 9597:ZNF548
uniprot id: A0A2R9BTA0
names: Function
messages: May be involved in transcriptional regulation.

9597:LZTFL1
gene id: 9597:LZTFL1
uniprot id: A0A2R8Z988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9597:FAM151A
gene id: 9597:FAM151A
uniprot id: A0A2R9A2C3
names: Similarity
messages: Belongs to the FAM151 family.

9597:ZNF189
gene id: 9597:ZNF189
uniprot id: A0A2R9AYB6
uniprot id: A0A2R9AZ15
names: Function
messages: May be involved in transcriptional regulation.

9597:PADI6
gene id: 9597:PADI6
uniprot id: A0A2R9C338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

9597:KCNB2
gene id: 9597:KCNB2
uniprot id: A0A2R9C703
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

9597:MOCS2
gene id: 9597:MOCS2
uniprot id: A0A2R9B0D2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9597:ALCAM
gene id: 9597:ALCAM
uniprot id: A0A2R9BTS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9597:CCL22
gene id: 9597:CCL22
uniprot id: A0A2R9C4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:NDEL1
gene id: 9597:NDEL1
uniprot id: A0A2R9BZ31
uniprot id: A0A2R9BZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9597:OPA3
gene id: 9597:OPA3
uniprot id: A0A2R9C1S7
uniprot id: A0A2R9C4S4
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9597:LOC100984505
gene id: 9597:LOC100984505
uniprot id: A0A2R8ZTY9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:DMC1
gene id: 9597:DMC1
uniprot id: A0A2R9BVM3
uniprot id: A0A2R9BW93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9597:EHD4
gene id: 9597:EHD4
uniprot id: A0A2R9CKA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9597:EFNA4
gene id: 9597:EFNA4
uniprot id: A0A2R8ZSX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:DYNLRB1
gene id: 9597:DYNLRB1
uniprot id: A0A2R9AEC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9597:SPCS1
gene id: 9597:SPCS1
uniprot id: A0A2R9AZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TNFSF15
gene id: 9597:TNFSF15
uniprot id: A0A2R8ZVZ2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:CTNND1
gene id: 9597:CTNND1
uniprot id: A0A2R9CFR2
uniprot id: A0A2R9CNM6
names: Similarity
messages: Belongs to the beta-catenin family.

9597:RPA3
gene id: 9597:RPA3
uniprot id: A0A2R9BSN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9597:OPRD1
gene id: 9597:OPRD1
uniprot id: A0A2R9CAS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:SPIC
gene id: 9597:SPIC
uniprot id: A0A2R9A5D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:SLC31A1
gene id: 9597:SLC31A1
uniprot id: A0A2R9AXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9597:TULP2
gene id: 9597:TULP2
uniprot id: A0A2R9BNS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9597:DUS4L
gene id: 9597:DUS4L
uniprot id: A0A2R9AM37
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9597:ITPRIPL1
gene id: 9597:ITPRIPL1
uniprot id: A0A2R9BRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9597:GPX8
gene id: 9597:GPX8
uniprot id: A0A2R9B4V9
uniprot id: A0A2R9B736
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9597:GNPDA2
gene id: 9597:GNPDA2
uniprot id: A0A2R9BM67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9597:GFM2
gene id: 9597:GFM2
uniprot id: A0A2R9BBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9597:TSEN34
gene id: 9597:TSEN34
uniprot id: A0A2R9BDN0
uniprot id: A0A2R9BM63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9597:VPS45
gene id: 9597:VPS45
uniprot id: A0A2R9BUS7
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9597:NIT2
gene id: 9597:NIT2
uniprot id: A0A2R9A3D8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9597:NMI
gene id: 9597:NMI
uniprot id: A0A2R9B1A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:ALDH1A3
gene id: 9597:ALDH1A3
uniprot id: A0A2R9CDK5
uniprot id: A0A2R9CLP3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:FAM122A
gene id: 9597:FAM122A
uniprot id: A0A2R8ZCM8
names: Similarity
messages: Belongs to the FAM122 family.

9597:NLGN3
gene id: 9597:NLGN3
uniprot id: A0A2R9A3K6
uniprot id: A0A2R9A705
uniprot id: A0A2R9A7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9597:KLC3
gene id: 9597:KLC3
uniprot id: A0A2R9CNL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9597:LUC7L3
gene id: 9597:LUC7L3
uniprot id: A0A2R8ZPS0
names: Similarity
messages: Belongs to the Luc7 family.

9597:AKR1A1
gene id: 9597:AKR1A1
uniprot id: A0A2R9ABJ2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9597:IFITM10
gene id: 9597:IFITM10
uniprot id: A0A2R8ZI05
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:LAMC3
gene id: 9597:LAMC3
uniprot id: A0A2R9AYI2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:FEN1
gene id: 9597:FEN1
uniprot id: A0A2R8ZQP1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9597:EIF5A
gene id: 9597:EIF5A
uniprot id: A0A2R9AUC9
uniprot id: A0A2R9AUE3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9597:SMARCA4
gene id: 9597:SMARCA4
uniprot id: A0A2R9CJH6
uniprot id: A0A2R9CJJ8
uniprot id: A0A2R9CSA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9597:MMGT1
gene id: 9597:MMGT1
uniprot id: A0A2R9AT41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9597:KCNA10
gene id: 9597:KCNA10
uniprot id: A0A2R8Z7H3
names: Subcellular Location Annotation
messages: Membrane

9597:EFNB3
gene id: 9597:EFNB3
uniprot id: A0A2R8ZZZ1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LSM1
gene id: 9597:LSM1
uniprot id: A0A2R9ARA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9597:NAPG
gene id: 9597:NAPG
uniprot id: A0A2R9B7E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9597:BLM
gene id: 9597:BLM
uniprot id: A0A2R9ATE2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9597:HMGCS2
gene id: 9597:HMGCS2
uniprot id: A0A2R9ASK2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9597:NRG4
gene id: 9597:NRG4
uniprot id: A0A2R9AS43
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:STARD3
gene id: 9597:STARD3
uniprot id: A0A2R9CKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:ZNF514
gene id: 9597:ZNF514
uniprot id: A0A2R9BJR5
names: Function
messages: May be involved in transcriptional regulation.

9597:CDH19
gene id: 9597:CDH19
uniprot id: A0A2R9BH09
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:BRINP2
gene id: 9597:BRINP2
uniprot id: A0A2R9CIU2
names: Similarity
messages: Belongs to the BRINP family.

9597:CORO1C
gene id: 9597:CORO1C
uniprot id: A0A2R9APZ3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9597:LMNA
gene id: 9597:LMNA
uniprot id: A0A2R9BK07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9597:CALHM4
gene id: 9597:CALHM4
uniprot id: A0A2R8ZL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:CAMK4
gene id: 9597:CAMK4
uniprot id: A0A2R9C7Q5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:RCAN2
gene id: 9597:RCAN2
uniprot id: A0A2R9A2S3
uniprot id: A0A2R9A643
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9597:MT1HL1
gene id: 9597:MT1HL1
uniprot id: A0A2R8ZNW3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:ZHX3
gene id: 9597:ZHX3
uniprot id: A0A2R8ZNU0
uniprot id: A0A2R8ZRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9597:KATNAL1
gene id: 9597:KATNAL1
uniprot id: A0A2R9ATJ5
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9597:EIF3M
gene id: 9597:EIF3M
uniprot id: A0A2R9A5V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9597:LOC100967703
gene id: 9597:LOC100967703
uniprot id: A0A2R9BJI5
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9597:SH3YL1
gene id: 9597:SH3YL1
uniprot id: A0A2R8ZFR7
uniprot id: A0A2R8ZG58
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9597:RPS18
gene id: 9597:RPS18
uniprot id: A0A2R8Z8K8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9597:LOC100971427
gene id: 9597:LOC100971427
uniprot id: A0A2R9AML4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SYBU
gene id: 9597:SYBU
uniprot id: A0A2R9AQN4
uniprot id: A0A2R9AR72
names: Subcellular Location Annotation
messages: Membrane

9597:POLR2G
gene id: 9597:POLR2G
uniprot id: A0A2R9BWD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9597:NLRP13
gene id: 9597:NLRP13
uniprot id: A0A2R9C5U1
names: Similarity
messages: Belongs to the NLRP family.

9597:GOT1L1
gene id: 9597:GOT1L1
uniprot id: A0A2R9BBX8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9597:STAT2
gene id: 9597:STAT2
uniprot id: A0A2R9C943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9597:OCIAD1
gene id: 9597:OCIAD1
uniprot id: A0A2R9CRP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9597:VAMP2
gene id: 9597:VAMP2
uniprot id: A0A2R8ZRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

9597:PSEN1
gene id: 9597:PSEN1
uniprot id: A0A2R9BSY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9597:ST8SIA2
gene id: 9597:ST8SIA2
uniprot id: A0A2R9CF06
uniprot id: A0A2R9CPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:CENPT
gene id: 9597:CENPT
uniprot id: A0A2R9B7U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9597:LOC100977810
gene id: 9597:LOC100977810
uniprot id: A0A2R8ZLX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SSR3
gene id: 9597:SSR3
uniprot id: A0A2R9B068
uniprot id: A0A2R9B4A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9597:PRUNE1
gene id: 9597:PRUNE1
uniprot id: A0A2R9AX72
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9597:ASB1
gene id: 9597:ASB1
uniprot id: A0A2R9BHF6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:RAD51D
gene id: 9597:RAD51D
uniprot id: A0A2R8ZQR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9597:ADPRH
gene id: 9597:ADPRH
uniprot id: A0A2R9BJB4
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9597:ANXA3
gene id: 9597:ANXA3
uniprot id: A0A2R9AXV0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9597:CDH6
gene id: 9597:CDH6
uniprot id: A0A2R9AUM4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:MED20
gene id: 9597:MED20
uniprot id: A0A2R9AU31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:PFAS
gene id: 9597:PFAS
uniprot id: A0A2R8ZP75
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9597:GPR161
gene id: 9597:GPR161
uniprot id: A0A2R9A4J3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:HHAT
gene id: 9597:HHAT
uniprot id: A0A2R9CD92
names: Subcellular Location Annotation
messages: Membrane

9597:CHMP1A
gene id: 9597:CHMP1A
uniprot id: A0A2R9AMQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9597:LOC100974914
gene id: 9597:LOC100974914
uniprot id: A0A2R8ZQ27
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LOC100975313
gene id: 9597:LOC100975313
uniprot id: A0A2R8ZK36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100986825
gene id: 9597:LOC100986825
uniprot id: A0A2R8ZFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ATP1B4
gene id: 9597:ATP1B4
uniprot id: A0A2R9BY14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9597:GPN2
gene id: 9597:GPN2
uniprot id: A0A2R9BVZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9597:LSM6
gene id: 9597:LSM6
uniprot id: A0A2R9BKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9597:MYO18B
gene id: 9597:MYO18B
uniprot id: A0A2R9ADT7
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NFXL1
gene id: 9597:NFXL1
uniprot id: A0A2R9CRL2
names: Similarity
messages: Belongs to the NFX1 family.

9597:DERL1
gene id: 9597:DERL1
uniprot id: A0A2R9CK79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9597:PPM1G
gene id: 9597:PPM1G
uniprot id: A0A2R9BH01
names: Similarity
messages: Belongs to the PP2C family.

9597:CA10
gene id: 9597:CA10
uniprot id: A0A2R9A615
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9597:BYSL
gene id: 9597:BYSL
uniprot id: A0A2R9A313
names: Similarity
messages: Belongs to the bystin family.

9597:PCDHB5
gene id: 9597:PCDHB5
uniprot id: A0A2R8Z686
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MRPS2
gene id: 9597:MRPS2
uniprot id: A0A2R9A4A5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

9597:LOC100976323
gene id: 9597:LOC100976323
uniprot id: A0A2R8ZGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RPTOR
gene id: 9597:RPTOR
uniprot id: A0A2R9CM07
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9597:PHKA2
gene id: 9597:PHKA2
uniprot id: A0A2R9BBG6
uniprot id: A0A2R9BFB2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9597:GRM3
gene id: 9597:GRM3
uniprot id: A0A2R9BG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9597:FAS
gene id: 9597:FAS
uniprot id: A0A2R9B6U6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9597:S100A5
gene id: 9597:S100A5
uniprot id: A0A2R9A8V2
names: Similarity
messages: Belongs to the S-100 family.

9597:SH2D1A
gene id: 9597:SH2D1A
uniprot id: A0A2R9BY26
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9597:SGPL1
gene id: 9597:SGPL1
uniprot id: A0A2R9B6W9
names: Similarity
messages: Belongs to the group II decarboxylase family.

9597:UFD1
gene id: 9597:UFD1
uniprot id: A0A2R9B7J8
names: Similarity
messages: Belongs to the UFD1 family.

9597:BOLA3
gene id: 9597:BOLA3
uniprot id: A0A2R9BV74
names: Similarity
messages: Belongs to the BolA/IbaG family.

9597:LIF
gene id: 9597:LIF
uniprot id: A0A2R8ZDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9597:DNTTIP1
gene id: 9597:DNTTIP1
uniprot id: A0A2R8ZVI0
names: Subcellular Location Annotation
messages: Nucleus

9597:ATP6V1B2
gene id: 9597:ATP6V1B2
uniprot id: A0A2R9CR87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9597:PTGES3
gene id: 9597:PTGES3
uniprot id: A0A2R8ZD55
uniprot id: A0A2R8ZD59
uniprot id: A0A2R8ZJX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9597:SLC6A2
gene id: 9597:SLC6A2
uniprot id: A0A2R9AJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:PDRG1
gene id: 9597:PDRG1
uniprot id: A0A2R9A910
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9597:GATA1
gene id: 9597:GATA1
uniprot id: A0A2R9B5B4
names: Subcellular Location Annotation
messages: Nucleus

9597:PRPS2
gene id: 9597:PRPS2
uniprot id: A0A2R9B019
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9597:ZEB2
gene id: 9597:ZEB2
uniprot id: A0A2R8ZPM1
uniprot id: A0A2R8ZSN8
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9597:BAK1
gene id: 9597:BAK1
uniprot id: A0A2R9A7S4
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:LOC100988794
gene id: 9597:LOC100988794
uniprot id: A0A2R8ZEZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CERS4
gene id: 9597:CERS4
uniprot id: A0A2R9CFQ2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:PHC1
gene id: 9597:PHC1
uniprot id: A0A2R9AEF7
names: Subcellular Location Annotation
messages: Nucleus

9597:AMIGO1
gene id: 9597:AMIGO1
uniprot id: A0A2R8ZDX0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9597:ASIC2
gene id: 9597:ASIC2
uniprot id: A0A2R9B5H0
uniprot id: A0A2R9BAN8
names: Subcellular Location Annotation
messages: Membrane

9597:TLL1
gene id: 9597:TLL1
uniprot id: A0A2R9BQX4
uniprot id: A0A2R9C010
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MTOR
gene id: 9597:MTOR
uniprot id: A0A2R9BI87
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9597:DKC1
gene id: 9597:DKC1
uniprot id: A0A2R8ZSQ5
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9597:CAVIN1
gene id: 9597:CAVIN1
uniprot id: A0A2R9B0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9597:PPIL1
gene id: 9597:PPIL1
uniprot id: A0A2R9ATX8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:LCE1C
gene id: 9597:LCE1C
uniprot id: A0A2R8Z5Y8
names: Similarity
messages: Belongs to the LCE family.

9597:CCL8
gene id: 9597:CCL8
uniprot id: A0A2R9BZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:MCUB
gene id: 9597:MCUB
uniprot id: A0A2R9ACB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:GMNN
gene id: 9597:GMNN
uniprot id: A0A2R9C717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9597:RARG
gene id: 9597:RARG
uniprot id: A0A2R9A2W6
uniprot id: A0A2R9A872
uniprot id: A0A2R9A880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:C1H1orf43
gene id: 9597:C1H1orf43
uniprot id: A0A2R9BG04
uniprot id: A0A2R9BJR2
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9597:TLR4
gene id: 9597:TLR4
uniprot id: B3Y628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:GLMP
gene id: 9597:GLMP
uniprot id: A0A2R9A1F5
uniprot id: A0A2R9A6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9597:PPIC
gene id: 9597:PPIC
uniprot id: A0A2R9CNV6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:FGFBP1
gene id: 9597:FGFBP1
uniprot id: A0A2R8ZKV9
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9597:HMMR
gene id: 9597:HMMR
uniprot id: A0A2R9ANT3
names: Subcellular Location Annotation
messages: spindle

9597:GJB4
gene id: 9597:GJB4
uniprot id: A0A2R8ZCY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:CBX5
gene id: 9597:CBX5
uniprot id: A0A2R9A4K7
names: Subcellular Location Annotation
messages: Nucleus

9597:ETFDH
gene id: 9597:ETFDH
uniprot id: A0A2R9B258
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9597:KAT5
gene id: 9597:KAT5
uniprot id: A0A2R9C9W8
uniprot id: A0A2R9CCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9597:AIFM1
gene id: 9597:AIFM1
uniprot id: A0A2R9AMY8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9597:CAPN12
gene id: 9597:CAPN12
uniprot id: A0A2R9BTR5
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:RBX1
gene id: 9597:RBX1
uniprot id: A0A2R9AIH9
names: Similarity
messages: Belongs to the RING-box family.

9597:ZC2HC1C
gene id: 9597:ZC2HC1C
uniprot id: A0A2R9AN57
names: Similarity
messages: Belongs to the ZC2HC1 family.

9597:EXOG
gene id: 9597:EXOG
uniprot id: A0A2R9AWM6
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9597:MS4A6A
gene id: 9597:MS4A6A
uniprot id: A0A2R8ZTT1
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

9597:MOG
gene id: 9597:MOG
uniprot id: A0A2R8ZJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9597:GUCA2A
gene id: 9597:GUCA2A
uniprot id: A0A2R9AA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9597:LOC100983542
gene id: 9597:LOC100983542
uniprot id: A0A2R8ZRN3
names: Function
messages: May be involved in transcriptional regulation.

9597:S100A9
gene id: 9597:S100A9
uniprot id: A0A2R9A6I5
names: Similarity
messages: Belongs to the S-100 family.

9597:SPPL2C
gene id: 9597:SPPL2C
uniprot id: A0A2R8ZT11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9597:KEF42 p12
gene id: 9597:KEF42_p12
uniprot id: E0XI70
uniprot id: Q9T9X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9597:POU3F4
gene id: 9597:POU3F4
uniprot id: A0A2R8ZGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9597:PLSCR4
gene id: 9597:PLSCR4
uniprot id: A0A2R9APM8
uniprot id: A0A2R9APN3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9597:UFC1
gene id: 9597:UFC1
uniprot id: A0A2R9BT93
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9597:CADM3
gene id: 9597:CADM3
uniprot id: A0A2R9CIJ2
uniprot id: A0A2R9CL84
names: Similarity
messages: Belongs to the nectin family.

9597:OAS1
gene id: 9597:OAS1
uniprot id: B6RC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9597:KIF5B
gene id: 9597:KIF5B
uniprot id: A0A2R9A2Q6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:GSTO2
gene id: 9597:GSTO2
uniprot id: A0A2R9AHG4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9597:WNT9B
gene id: 9597:WNT9B
uniprot id: A0A2R9AVU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:PTPN14
gene id: 9597:PTPN14
uniprot id: A0A2R9AKT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9597:PIN4
gene id: 9597:PIN4
uniprot id: A0A2R9B5P5
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9597:POC5
gene id: 9597:POC5
uniprot id: A0A2R9BIF3
uniprot id: A0A2R9BLY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

9597:CP
gene id: 9597:CP
uniprot id: A0A2R9AYC2
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:ARGLU1
gene id: 9597:ARGLU1
uniprot id: A0A2R9ACG3
names: Similarity
messages: Belongs to the UPF0430 family.

9597:ACADVL
gene id: 9597:ACADVL
uniprot id: A0A2R9BXB4
uniprot id: A0A2R9C0N0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:ADCY10
gene id: 9597:ADCY10
uniprot id: A0A2R9AU90
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.

9597:MAX
gene id: 9597:MAX
uniprot id: A0A2R9C7H0
uniprot id: A0A2R9C7R9
uniprot id: A0A2R9CA70
uniprot id: A0A2R9CHZ6
names: Similarity
messages: Belongs to the MAX family.

9597:TMPO
gene id: 9597:TMPO
uniprot id: A0A2R9AK93
names: Similarity
messages: Belongs to the LEM family.

9597:HHATL
gene id: 9597:HHATL
uniprot id: A0A2R8ZYE8
names: Subcellular Location Annotation
messages: Membrane

9597:GLRB
gene id: 9597:GLRB
uniprot id: A0A2R8ZFL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9597:TRIM32
gene id: 9597:TRIM32
uniprot id: A0A2R8ZPX3
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9597:AATF
gene id: 9597:AATF
uniprot id: A0A2R9C8A1
names: Similarity
messages: Belongs to the AATF family.

9597:LOC100987821
gene id: 9597:LOC100987821
uniprot id: A0A2R9C017
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:LY6D
gene id: 9597:LY6D
uniprot id: A0A2R9C091
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:ZNF688
gene id: 9597:ZNF688
uniprot id: A0A2R9B8U9
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100974795
gene id: 9597:LOC100974795
uniprot id: A0A2R8ZIJ8
names: Similarity
messages: Belongs to the histone H3 family.

9597:COPA
gene id: 9597:COPA
uniprot id: A0A2R9A2F0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9597:SFXN2
gene id: 9597:SFXN2
uniprot id: A0A2R9AMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9597:ATP6V1B1
gene id: 9597:ATP6V1B1
uniprot id: A0A2R8ZSZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9597:RAP1GDS1
gene id: 9597:RAP1GDS1
uniprot id: A0A2R9AA08
uniprot id: A0A2R9AA23
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

9597:HCFC1
gene id: 9597:HCFC1
uniprot id: A0A2R9CM34
names: Subcellular Location Annotation
messages: Nucleus

9597:CETN1
gene id: 9597:CETN1
uniprot id: A0A2R9AQL0
names: Similarity
messages: Belongs to the centrin family.

9597:SLC9A3R1
gene id: 9597:SLC9A3R1
uniprot id: A0A2R8ZEL3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

9597:MRPL23
gene id: 9597:MRPL23
uniprot id: A0A2R9AYS2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9597:NDUFB8
gene id: 9597:NDUFB8
uniprot id: A0A2R8ZUX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:LOC100981885
gene id: 9597:LOC100981885
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CCN1
gene id: 9597:CCN1
uniprot id: A0A2R9BFM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:PLIN2
gene id: 9597:PLIN2
uniprot id: A0A2R8ZBB9
uniprot id: A0A2R8ZI15
names: Similarity
messages: Belongs to the perilipin family.

9597:RPL9
gene id: 9597:RPL9
uniprot id: A0A2R9CDD2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9597:TBPL2
gene id: 9597:TBPL2
uniprot id: A0A2R9AQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9597:ACAT1
gene id: 9597:ACAT1
uniprot id: A0A2R9B6L3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9597:DYRK4
gene id: 9597:DYRK4
uniprot id: A0A2R9BQ13
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9597:PKLR
gene id: 9597:PKLR
uniprot id: A0A2R9C0K5
names: Similarity
messages: Belongs to the pyruvate kinase family.

9597:BACE1
gene id: 9597:BACE1
uniprot id: A0A2R9BN30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9597:HAPLN2
gene id: 9597:HAPLN2
uniprot id: A0A2R9AH74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NTAQ1
gene id: 9597:NTAQ1
uniprot id: A0A2R9CD66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9597:ACTA1
gene id: 9597:ACTA1
uniprot id: A0A2R9AZU8
names: Similarity
messages: Belongs to the actin family.

9597:TCP11L2
gene id: 9597:TCP11L2
uniprot id: A0A2R9C876
uniprot id: A0A2R9CIX0
names: Similarity
messages: Belongs to the TCP11 family.

9597:PLPP4
gene id: 9597:PLPP4
uniprot id: A0A2R9C2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:HNMT
gene id: 9597:HNMT
uniprot id: A0A2R9A9L0
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9597:SCGB1A1
gene id: 9597:SCGB1A1
uniprot id: A0A2R9BEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9597:FAM216B
gene id: 9597:FAM216B
uniprot id: A0A2R8Z672
names: Similarity
messages: Belongs to the FAM216 family.

9597:TCL1B
gene id: 9597:TCL1B
uniprot id: A0A2R9B5B6
names: Similarity
messages: Belongs to the TCL1 family.

9597:TMEM14C
gene id: 9597:TMEM14C
uniprot id: A0A2R9BX17
names: Similarity
messages: Belongs to the TMEM14 family.

9597:CCN6
gene id: 9597:CCN6
uniprot id: A0A2R9CIT0
uniprot id: A0A2R9CLI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:UBL3
gene id: 9597:UBL3
uniprot id: A0A2R8ZU73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:TOMM40L
gene id: 9597:TOMM40L
uniprot id: A0A2R9C7B2
uniprot id: A0A2R9C7B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:THUMPD3
gene id: 9597:THUMPD3
uniprot id: A0A2R8ZQS5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9597:ADSS2
gene id: 9597:ADSS2
uniprot id: A0A2R9B5Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9597:DMAC2L
gene id: 9597:DMAC2L
uniprot id: A0A2R8ZLR0
uniprot id: A0A2R8ZNG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9597:IL17F
gene id: 9597:IL17F
uniprot id: A0A2R9BY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:LAMA4
gene id: 9597:LAMA4
uniprot id: A0A2R9C435
names: Caution
names: Function
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:BTC
gene id: 9597:BTC
uniprot id: A0A2R9AUY6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GPR55
gene id: 9597:GPR55
uniprot id: A0A2R8ZCP7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:MRPS18B
gene id: 9597:MRPS18B
uniprot id: A0A2R9BVF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9597:FBXO34
gene id: 9597:FBXO34
uniprot id: A0A2R8ZNG7
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9597:TARS2
gene id: 9597:TARS2
uniprot id: A0A2R9C9N8
uniprot id: A0A2R9CCD5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:ERBB2
gene id: 9597:ERBB2
uniprot id: A0A2R9C656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9597:BMP7
gene id: 9597:BMP7
uniprot id: A0A2R9AT21
names: Similarity
messages: Belongs to the TGF-beta family.

9597:TMEM184C
gene id: 9597:TMEM184C
uniprot id: A0A2R9AN83
names: Subcellular Location Annotation
messages: Membrane

9597:BTG3
gene id: 9597:BTG3
uniprot id: A0A2R9CEI1
names: Similarity
messages: Belongs to the BTG family.

9597:MMP3
gene id: 9597:MMP3
uniprot id: A0A2R9BCT7
names: Similarity
messages: Belongs to the peptidase M10A family.

9597:ACTN1
gene id: 9597:ACTN1
uniprot id: A0A2R9BFF0
uniprot id: A0A2R9BFF6
uniprot id: A0A2R9BFG1
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:SLC12A4
gene id: 9597:SLC12A4
uniprot id: A0A2R9B4J5
uniprot id: A0A2R9BBG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9597:LOC100988550
gene id: 9597:LOC100988550
uniprot id: A0A2R9CAA2
uniprot id: A0A2R9CAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9597:PTTG1
gene id: 9597:PTTG1
uniprot id: A0A2R9ABT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9597:YIF1A
gene id: 9597:YIF1A
uniprot id: A0A2R9C3C9
uniprot id: A0A2R9C6E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FAM91A1
gene id: 9597:FAM91A1
uniprot id: A0A2R9ANI6
names: Similarity
messages: Belongs to the FAM91 family.

9597:CCL1
gene id: 9597:CCL1
uniprot id: A0A2R8Z7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:SPSB3
gene id: 9597:SPSB3
uniprot id: A0A2R8ZKW4
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:CCNY
gene id: 9597:CCNY
uniprot id: A0A2R8ZQK7
uniprot id: A0A2R8ZQL2
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9597:LMBR1L
gene id: 9597:LMBR1L
uniprot id: A0A2R9CHP9
names: Similarity
messages: Belongs to the LIMR family.

9597:TMC5
gene id: 9597:TMC5
uniprot id: A0A2R9B896
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:ZNF556
gene id: 9597:ZNF556
uniprot id: A0A2R8ZLP9
names: Function
messages: May be involved in transcriptional regulation.

9597:INPP5D
gene id: 9597:INPP5D
uniprot id: A0A2R9AEZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

9597:ACAN
gene id: 9597:ACAN
uniprot id: A0A2R9BUF1
uniprot id: A0A2R9C002
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:NDUFAF3
gene id: 9597:NDUFAF3
uniprot id: A0A2R9BLA4
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9597:BTN3A1
gene id: 9597:BTN3A1
uniprot id: A0A2R9CCX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9597:BROX
gene id: 9597:BROX
uniprot id: A0A2R9BSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

9597:MATK
gene id: 9597:MATK
uniprot id: A0A2R8ZAM3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:CCHCR1
gene id: 9597:CCHCR1
uniprot id: A0A2R8ZZ61
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9597:CETN2
gene id: 9597:CETN2
uniprot id: A0A2R9BTG6
names: Similarity
messages: Belongs to the centrin family.

9597:SKIL
gene id: 9597:SKIL
uniprot id: A0A2R9A8L9
uniprot id: A0A2R9A8M4
names: Similarity
messages: Belongs to the SKI family.

9597:KCNJ9
gene id: 9597:KCNJ9
uniprot id: A0A2R9B157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:UCK1
gene id: 9597:UCK1
uniprot id: A0A2R9CFB1
uniprot id: A0A2R9CHS8
names: Similarity
messages: Belongs to the uridine kinase family.

9597:SPDYA
gene id: 9597:SPDYA
uniprot id: A0A2R9BDL4
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9597:TNS2
gene id: 9597:TNS2
uniprot id: A0A2R9B4X9
uniprot id: A0A2R9B4Y4
uniprot id: A0A2R9B8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9597:FAM8A1
gene id: 9597:FAM8A1
uniprot id: A0A2R8ZU30
names: Subcellular Location Annotation
messages: Membrane

9597:UBA1
gene id: 9597:UBA1
uniprot id: A0A2R9BUW2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9597:HIBADH
gene id: 9597:HIBADH
uniprot id: A0A2R9CNE8
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9597:SF1
gene id: 9597:SF1
uniprot id: A0A2R8ZCW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9597:CWF19L1
gene id: 9597:CWF19L1
uniprot id: A0A2R9ASJ2
names: Similarity
messages: Belongs to the CWF19 family.

9597:FABP7
gene id: 9597:FABP7
uniprot id: A0A2R9ABE2
uniprot id: A0A2R9AGA6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:NXPE3
gene id: 9597:NXPE3
uniprot id: A0A2R9B367
names: Similarity
messages: Belongs to the NXPE family.

9597:SYT2
gene id: 9597:SYT2
uniprot id: A0A2R9BB69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9597:TMLHE
gene id: 9597:TMLHE
uniprot id: A0A2R9BGE1
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9597:SULT1C4
gene id: 9597:SULT1C4
uniprot id: A0A2R9BNR2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:CCNB1
gene id: 9597:CCNB1
uniprot id: A0A2R9CK63
names: Similarity
messages: Belongs to the cyclin family.

9597:SLC26A8
gene id: 9597:SLC26A8
uniprot id: A0A2R9BTP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9597:TFDP1
gene id: 9597:TFDP1
uniprot id: A0A2R9AK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:NID1
gene id: 9597:NID1
uniprot id: A0A2R9AXE3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9597:TRAPPC3
gene id: 9597:TRAPPC3
uniprot id: A0A2R9CEI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9597:KEF42 p10
gene id: 9597:KEF42_p10
uniprot id: E0XI98
uniprot id: P26457
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9597:BGLAP
gene id: 9597:BGLAP
uniprot id: A0A2R9CDC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9597:HEBP2
gene id: 9597:HEBP2
uniprot id: A0A2R9C6L5
names: Similarity
messages: Belongs to the HEBP family.

9597:MMD2
gene id: 9597:MMD2
uniprot id: A0A2R9CCE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:AZIN2
gene id: 9597:AZIN2
uniprot id: A0A2R9AAQ7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9597:BBS5
gene id: 9597:BBS5
uniprot id: A0A2R9BW62
uniprot id: A0A2R9BWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9597:LOC100970874
gene id: 9597:LOC100970874
uniprot id: A0A2R9C5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9597:ZNF543
gene id: 9597:ZNF543
uniprot id: A0A2R9B0R2
names: Function
messages: May be involved in transcriptional regulation.

9597:GDF2
gene id: 9597:GDF2
uniprot id: A0A2R8ZGL7
names: Similarity
messages: Belongs to the TGF-beta family.

9597:CCL13
gene id: 9597:CCL13
uniprot id: A0A2R9C8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:UGT2B4
gene id: 9597:UGT2B4
uniprot id: A0A2R8ZJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:ADORA1
gene id: 9597:ADORA1
uniprot id: A0A2R9AWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9597:MYH8
gene id: 9597:MYH8
uniprot id: A0A2R9BPX7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:COG3
gene id: 9597:COG3
uniprot id: A0A2R9AUL1
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9597:CUL7
gene id: 9597:CUL7
uniprot id: A0A2R9B5F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9597:ALKBH6
gene id: 9597:ALKBH6
uniprot id: A0A2R9BCU9
uniprot id: A0A2R9BGS0
names: Similarity
messages: Belongs to the alkB family.

9597:CHPF
gene id: 9597:CHPF
uniprot id: A0A2R9AJP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:FOXS1
gene id: 9597:FOXS1
uniprot id: A0A2R9ARS5
names: Subcellular Location Annotation
messages: Nucleus

9597:MFSD9
gene id: 9597:MFSD9
uniprot id: A0A2R9BZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9597:NUP50
gene id: 9597:NUP50
uniprot id: A0A2R9ATL1
names: Subcellular Location Annotation
messages: nuclear pore complex

9597:ANXA4
gene id: 9597:ANXA4
uniprot id: A0A2R9A478
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9597:DHX29
gene id: 9597:DHX29
uniprot id: A0A2R9C7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9597:PNLIP
gene id: 9597:PNLIP
uniprot id: A0A2R8ZH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9597:CCL19
gene id: 9597:CCL19
uniprot id: A0A2R9ARU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:ADAMTS14
gene id: 9597:ADAMTS14
uniprot id: A0A2R9A0L5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:LPAR6
gene id: 9597:LPAR6
uniprot id: A0A2R8ZD42
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:CENPN
gene id: 9597:CENPN
uniprot id: A0A2R9B8F1
uniprot id: A0A2R9B8F7
uniprot id: A0A2R9B9W8
uniprot id: A0A2R9BC57
uniprot id: A0A2R9BFV1
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9597:MRPL14
gene id: 9597:MRPL14
uniprot id: A0A2R9BD85
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9597:NME6
gene id: 9597:NME6
uniprot id: A0A2R9BF56
names: Similarity
messages: Belongs to the NDK family.

9597:MFAP3L
gene id: 9597:MFAP3L
uniprot id: A0A2R9C413
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:SEPTIN12
gene id: 9597:SEPTIN12
uniprot id: A0A2R9B1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:PURG
gene id: 9597:PURG
uniprot id: A0A2R9B1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9597:LHCGR
gene id: 9597:LHCGR
uniprot id: A0A2R9APW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9597:FOXI2
gene id: 9597:FOXI2
uniprot id: A0A2R9BTX1
names: Subcellular Location Annotation
messages: Nucleus

9597:MTMR4
gene id: 9597:MTMR4
uniprot id: A0A2R9C5A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9597:CTNNBIP1
gene id: 9597:CTNNBIP1
uniprot id: A0A2R8ZXT9
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9597:RPS6KB2
gene id: 9597:RPS6KB2
uniprot id: A0A2R8ZFT7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:FLI1
gene id: 9597:FLI1
uniprot id: A0A2R9C1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:PPP2R5C
gene id: 9597:PPP2R5C
uniprot id: A0A2R9BML8
uniprot id: A0A2R9BNF8
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:GJB6
gene id: 9597:GJB6
uniprot id: A0A2R8ZJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:SH3BGR
gene id: 9597:SH3BGR
uniprot id: A0A2R9BED8
names: Similarity
messages: Belongs to the SH3BGR family.

9597:SLC49A3
gene id: 9597:SLC49A3
uniprot id: A0A2R9C4V5
names: Subcellular Location Annotation
messages: Membrane

9597:NR0B1
gene id: 9597:NR0B1
uniprot id: A0A2R8ZNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9597:NOTCH4
gene id: 9597:NOTCH4
uniprot id: A0A2R9AC37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9597:ZNF284
gene id: 9597:ZNF284
uniprot id: A0A2R9AK22
names: Function
messages: May be involved in transcriptional regulation.

9597:MOB1A
gene id: 9597:MOB1A
uniprot id: A0A2R9C5D4
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:CDH18
gene id: 9597:CDH18
uniprot id: A0A2R9C061
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:TOMM20
gene id: 9597:TOMM20
uniprot id: A0A2R9ABS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:EIF4G1
gene id: 9597:EIF4G1
uniprot id: A0A2R9CEB6
uniprot id: A0A2R9CPE2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9597:ELOA
gene id: 9597:ELOA
uniprot id: A0A2R8Z8S5
names: Subcellular Location Annotation
messages: Nucleus

9597:TJP1
gene id: 9597:TJP1
uniprot id: A0A2R9C179
uniprot id: A0A2R9C480
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:IRX6
gene id: 9597:IRX6
uniprot id: A0A2R8ZGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9597:GNB4
gene id: 9597:GNB4
uniprot id: A0A2R9CN27
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9597:SYNPR
gene id: 9597:SYNPR
uniprot id: A0A2R9BE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9597:ZKSCAN3
gene id: 9597:ZKSCAN3
uniprot id: A0A2R9BX51
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:CASP2
gene id: 9597:CASP2
uniprot id: A0A2R9A1X3
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:PIM2
gene id: 9597:PIM2
uniprot id: A0A2R9C4I5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9597:TBRG1
gene id: 9597:TBRG1
uniprot id: A0A2R9A871
names: Subcellular Location Annotation
messages: Nucleus

9597:PRKAR1B
gene id: 9597:PRKAR1B
uniprot id: A0A2R9BW82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9597:MRPL36
gene id: 9597:MRPL36
uniprot id: A0A2R8ZJI9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9597:IZUMO1R
gene id: 9597:IZUMO1R
uniprot id: A0A2R9C5Y0
names: Similarity
messages: Belongs to the folate receptor family.

9597:LOC100979972
gene id: 9597:LOC100979972
uniprot id: P61639
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:PPARG
gene id: 9597:PPARG
uniprot id: A0A2R9A3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9597:SCIN
gene id: 9597:SCIN
uniprot id: A0A2R9CL46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9597:AP4B1
gene id: 9597:AP4B1
uniprot id: A0A2R9BMU2
uniprot id: A0A2R9BMW7
uniprot id: A0A2R9BNP5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:TPMT
gene id: 9597:TPMT
uniprot id: A0A2R9A781
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9597:CNIH1
gene id: 9597:CNIH1
uniprot id: A0A2R9AH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9597:AMPD2
gene id: 9597:AMPD2
uniprot id: A0A2R9A068
uniprot id: A0A2R9A5P5
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9597:FH
gene id: 9597:FH
uniprot id: A0A2R9A8K1
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9597:UBE2T
gene id: 9597:UBE2T
uniprot id: A0A2R9B0J5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:SIRT5
gene id: 9597:SIRT5
uniprot id: A0A2R9AH39
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9597:ATP5MC3
gene id: 9597:ATP5MC3
uniprot id: A0A2R9BB70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9597:LOC100987427
gene id: 9597:LOC100987427
uniprot id: A0A2R9A2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CCNYL1
gene id: 9597:CCNYL1
uniprot id: A0A2R9B0L8
uniprot id: A0A2R9B2L1
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9597:FITM1
gene id: 9597:FITM1
uniprot id: A0A2R9ANF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9597:BBOF1
gene id: 9597:BBOF1
uniprot id: A0A2R9B2V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9597:PSMC6
gene id: 9597:PSMC6
uniprot id: A0A2R9AV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100979908
gene id: 9597:LOC100979908
uniprot id: A0A2R8ZL50
names: Subcellular Location Annotation
messages: Nucleus

9597:HARS2
gene id: 9597:HARS2
uniprot id: A0A2R9BX99
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:ZNF768
gene id: 9597:ZNF768
uniprot id: A0A2R9BTQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100995751
gene id: 9597:LOC100995751
uniprot id: A0A2R8Z604
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LCN12
gene id: 9597:LCN12
uniprot id: A0A2R9C009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9597:H1-1
gene id: 9597:H1-1
uniprot id: A0A2R8ZJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9597:LMNB1
gene id: 9597:LMNB1
uniprot id: A0A2R9BUC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9597:MED11
gene id: 9597:MED11
uniprot id: A0A2R8ZI02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:CR1L
gene id: 9597:CR1L
uniprot id: A0A2R8Z9Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TENM2
gene id: 9597:TENM2
uniprot id: A0A2R9BEF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TM4SF18
gene id: 9597:TM4SF18
uniprot id: A0A2R9BTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9597:CENPX
gene id: 9597:CENPX
uniprot id: A0A2R9A6P0
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9597:SAMD8
gene id: 9597:SAMD8
uniprot id: A0A2R9B5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9597:GTPBP3
gene id: 9597:GTPBP3
uniprot id: A0A2R8ZUU2
uniprot id: A0A2R8ZVY6
uniprot id: A0A2R8ZVZ0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9597:PIK3C2A
gene id: 9597:PIK3C2A
uniprot id: A0A2R9BSX3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:LOC100993304
gene id: 9597:LOC100993304
uniprot id: A0A2R8ZFL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:HPS3
gene id: 9597:HPS3
uniprot id: A0A2R8ZYI6
uniprot id: A0A2R9A2W9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9597:LOC100995379
gene id: 9597:LOC100995379
uniprot id: A0A2R8Z7D9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:ASAH1
gene id: 9597:ASAH1
uniprot id: A0A2R9A1T9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Belongs to the peptidase C59 family.
messages: Heterodimer.
messages: Lysosome

9597:NRP1
gene id: 9597:NRP1
uniprot id: A0A2R8Z673
uniprot id: A0A2R8Z9X4
uniprot id: A0A2R8Z9Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FOXJ3
gene id: 9597:FOXJ3
uniprot id: A0A2R9B2M3
names: Subcellular Location Annotation
messages: Nucleus

9597:PYCARD
gene id: 9597:PYCARD
uniprot id: A0A2R9CG76
uniprot id: A0A2R9CGD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9597:SPIN4
gene id: 9597:SPIN4
uniprot id: A0A2R8ZMM1
names: Similarity
messages: Belongs to the SPIN/STSY family.

9597:FAM133A
gene id: 9597:FAM133A
uniprot id: A0A2R8ZJW3
names: Similarity
messages: Belongs to the FAM133 family.

9597:ACAT2
gene id: 9597:ACAT2
uniprot id: A0A2R9CJL2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9597:NXF3
gene id: 9597:NXF3
uniprot id: A0A2R9AJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9597:EI24
gene id: 9597:EI24
uniprot id: A0A2R9A0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9597:LOC100981014
gene id: 9597:LOC100981014
uniprot id: A0A2R9A7B2
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:ZNF155
gene id: 9597:ZNF155
uniprot id: A0A2R8ZK98
names: Function
messages: May be involved in transcriptional regulation.

9597:GPRC5B
gene id: 9597:GPRC5B
uniprot id: A0A2R8ZYF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:UFM1
gene id: 9597:UFM1
uniprot id: A0A2R9AIR5
uniprot id: A0A2R9AML1
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9597:CRK
gene id: 9597:CRK
uniprot id: A0A2R9A9X4
names: Similarity
messages: Belongs to the CRK family.

9597:EID2B
gene id: 9597:EID2B
uniprot id: A0A2R8ZJ03
names: Subcellular Location Annotation
messages: Nucleus

9597:MAN2A1
gene id: 9597:MAN2A1
uniprot id: A0A2R9BN84
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9597:PARP3
gene id: 9597:PARP3
uniprot id: A0A2R9C2I5
uniprot id: A0A2R9C302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9597:USP2
gene id: 9597:USP2
uniprot id: A0A2R8ZT66
uniprot id: A0A2R8ZXT1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:LOC100995836
gene id: 9597:LOC100995836
uniprot id: A0A2R8ZAQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9597:METTL6
gene id: 9597:METTL6
uniprot id: A0A2R9BTN7
uniprot id: A0A2R9BTP2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9597:NUS1
gene id: 9597:NUS1
uniprot id: A0A2R8ZGV4
names: Similarity
messages: Belongs to the UPP synthase family.

9597:SERPINI1
gene id: 9597:SERPINI1
uniprot id: A0A2R9BSS5
names: Similarity
messages: Belongs to the serpin family.

9597:CCDC124
gene id: 9597:CCDC124
uniprot id: A0A2R9AG76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9597:LOC100991027
gene id: 9597:LOC100991027
uniprot id: A0A2R9APU6
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9597:CNOT10
gene id: 9597:CNOT10
uniprot id: A0A2R8ZSB5
uniprot id: A0A2R8ZSB8
uniprot id: A0A2R8ZY54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9597:RAD23A
gene id: 9597:RAD23A
uniprot id: A0A2R8ZJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9597:SLC15A2
gene id: 9597:SLC15A2
uniprot id: A0A2R9BFL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9597:GTF3C5
gene id: 9597:GTF3C5
uniprot id: A0A2R9A3I3
names: Subcellular Location Annotation
messages: Nucleus

9597:SMPD1
gene id: 9597:SMPD1
uniprot id: A0A2R9AIC5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9597:RELN
gene id: 9597:RELN
uniprot id: A0A2R9B232
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

9597:LOC100983379
gene id: 9597:LOC100983379
uniprot id: A0A2R8Z6H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:OGDH
gene id: 9597:OGDH
uniprot id: A0A2R9C111
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9597:ARPIN
gene id: 9597:ARPIN
uniprot id: A0A2R9C3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

9597:UBP1
gene id: 9597:UBP1
uniprot id: A0A2R8ZZJ8
uniprot id: A0A2R9A0P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9597:POLR1A
gene id: 9597:POLR1A
uniprot id: A0A2R9CCE6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9597:PGM1
gene id: 9597:PGM1
uniprot id: A0A2R9BID9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9597:PPP1R21
gene id: 9597:PPP1R21
uniprot id: A0A2R9AKC2
uniprot id: A0A2R9AKD9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9597:SPECC1L
gene id: 9597:SPECC1L
uniprot id: A0A2R9AC63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9597:ATP6V0A2
gene id: 9597:ATP6V0A2
uniprot id: A0A2R9BD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9597:INPP4A
gene id: 9597:INPP4A
uniprot id: A0A2R9AA28
uniprot id: A0A2R9AF05
uniprot id: A0A2R9AFR6
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9597:SH3BP4
gene id: 9597:SH3BP4
uniprot id: A0A2R9CSM6
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9597:ZNF132
gene id: 9597:ZNF132
uniprot id: A0A2R9C8I9
names: Function
messages: May be involved in transcriptional regulation.

9597:MRPL33
gene id: 9597:MRPL33
uniprot id: A0A2R9AMU4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9597:EDNRA
gene id: 9597:EDNRA
uniprot id: A0A2R9BHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9597:EXOC7
gene id: 9597:EXOC7
uniprot id: A0A2R9BRH7
uniprot id: A0A2R9BRI1
uniprot id: A0A2R9BRI5
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9597:GAPDHS
gene id: 9597:GAPDHS
uniprot id: A0A2R8Z5R8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9597:MYADM
gene id: 9597:MYADM
uniprot id: A0A2R8Z748
names: Subcellular Location Annotation
messages: Membrane

9597:BANF2
gene id: 9597:BANF2
uniprot id: A0A2R8ZXI3
names: Subcellular Location Annotation
messages: Nucleus

9597:TMEM144
gene id: 9597:TMEM144
uniprot id: A0A2R9AD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9597:EGR2
gene id: 9597:EGR2
uniprot id: A0A2R9BFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9597:TBX4
gene id: 9597:TBX4
uniprot id: A0A2R9BRB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:SHOC2
gene id: 9597:SHOC2
uniprot id: A0A2R9CDZ7
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9597:TMEM175
gene id: 9597:TMEM175
uniprot id: A0A2R8Z6H9
uniprot id: A0A2R8Z6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9597:OGDHL
gene id: 9597:OGDHL
uniprot id: A0A2R9B524
uniprot id: A0A2R9B8T2
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9597:OXSM
gene id: 9597:OXSM
uniprot id: A0A2R9APM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9597:PRPH2
gene id: 9597:PRPH2
uniprot id: A0A2R9B7L6
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9597:TFRC
gene id: 9597:TFRC
uniprot id: A0A2R8ZIZ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9597:ALG8
gene id: 9597:ALG8
uniprot id: A0A2R9ABB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:KEF42 p09
gene id: 9597:KEF42_p09
uniprot id: Q35587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

9597:WASF3
gene id: 9597:WASF3
uniprot id: A0A2R9B7U3
uniprot id: A0A2R9BDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9597:HOXA6
gene id: 9597:HOXA6
uniprot id: A0A2R9BXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:C11H11orf58
gene id: 9597:C11H11orf58
uniprot id: A0A2R9B475
names: Similarity
messages: Belongs to the SMAP family.

9597:LOC100982295
gene id: 9597:LOC100982295
uniprot id: A0A2R8ZMB2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:NR1I3
gene id: 9597:NR1I3
uniprot id: A0A2R8ZWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:ABI3
gene id: 9597:ABI3
uniprot id: A0A2R8ZV64
names: Similarity
messages: Belongs to the ABI family.

9597:LCN1
gene id: 9597:LCN1
uniprot id: A0A2R9BEH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9597:TNS4
gene id: 9597:TNS4
uniprot id: A0A2R8ZYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9597:DRP2
gene id: 9597:DRP2
uniprot id: A0A2R8Z9Q8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
messages: dendrite

9597:CORO2A
gene id: 9597:CORO2A
uniprot id: A0A2R9C3A8
names: Similarity
messages: Belongs to the WD repeat coronin family.

9597:ACTR1B
gene id: 9597:ACTR1B
uniprot id: A0A2R8ZL16
names: Similarity
messages: Belongs to the actin family.

9597:TMEM86A
gene id: 9597:TMEM86A
uniprot id: A0A2R9AAR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9597:EPHA8
gene id: 9597:EPHA8
uniprot id: A0A2R9CCC4
names: Subcellular Location Annotation
messages: Membrane

9597:CLCA2
gene id: 9597:CLCA2
uniprot id: A0A2R9BHZ5
names: Similarity
messages: Belongs to the CLCR family.

9597:NAT2
gene id: 9597:NAT2
uniprot id: A0A2R8ZIN0
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9597:PRKDC
gene id: 9597:PRKDC
uniprot id: A0A2R9A952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: nucleolus

9597:LOC100975092
gene id: 9597:LOC100975092
uniprot id: A0A2R9C257
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9597:TACC3
gene id: 9597:TACC3
uniprot id: A0A2R9C4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9597:DCLRE1B
gene id: 9597:DCLRE1B
uniprot id: A0A2R9AH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9597:SFR1
gene id: 9597:SFR1
uniprot id: A0A2R9BFZ8
uniprot id: A0A2R9BJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9597:DOK2
gene id: 9597:DOK2
uniprot id: A0A2R9BT20
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9597:F3
gene id: 9597:F3
uniprot id: A0A2R9AQY7
uniprot id: A0A2R9AXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9597:GPRC5A
gene id: 9597:GPRC5A
uniprot id: A0A2R9AIZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:DMRT1
gene id: 9597:DMRT1
uniprot id: A0A2R9BLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9597:PLCB3
gene id: 9597:PLCB3
uniprot id: A0A2R9CAD8
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9597:HNRNPDL
gene id: 9597:HNRNPDL
uniprot id: A0A2R9CQQ7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:IREB2
gene id: 9597:IREB2
uniprot id: A0A2R9BR28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9597:DLG1
gene id: 9597:DLG1
uniprot id: A0A2R9AUN2
uniprot id: A0A2R9AUP6
uniprot id: A0A2R9AUP8
uniprot id: A0A2R9B0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9597:DCPS
gene id: 9597:DCPS
uniprot id: A0A2R9AJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9597:ILKAP
gene id: 9597:ILKAP
uniprot id: A0A2R9CGB5
names: Similarity
messages: Belongs to the PP2C family.

9597:ARVCF
gene id: 9597:ARVCF
uniprot id: A0A2R8ZT99
uniprot id: A0A2R8ZTA6
names: Similarity
messages: Belongs to the beta-catenin family.

9597:ACTG2
gene id: 9597:ACTG2
uniprot id: A0A2R9A4B9
uniprot id: A0A2R9A5I8
names: Similarity
messages: Belongs to the actin family.

9597:RPL14
gene id: 9597:RPL14
uniprot id: A0A2R9A518
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9597:PARP9
gene id: 9597:PARP9
uniprot id: A0A2R9CL01
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:PRNP
gene id: 9597:PRNP
uniprot id: A0A2R8ZHM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9597:CHI3L1
gene id: 9597:CHI3L1
uniprot id: A0A2R9ASJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space

9597:SUGP1
gene id: 9597:SUGP1
uniprot id: A0A2R9BII1
names: Subcellular Location Annotation
messages: Nucleus

9597:KARS1
gene id: 9597:KARS1
uniprot id: A0A2R9BGP9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:CNEP1R1
gene id: 9597:CNEP1R1
uniprot id: A0A2R8ZX45
uniprot id: A0A2R9A0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9597:USP45
gene id: 9597:USP45
uniprot id: A0A2R9AZS7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:MRPS9
gene id: 9597:MRPS9
uniprot id: A0A2R9BGM3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9597:CHD4
gene id: 9597:CHD4
uniprot id: A0A2R9A4P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9597:ATP6V1G3
gene id: 9597:ATP6V1G3
uniprot id: A0A2R9B0Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:SLC29A2
gene id: 9597:SLC29A2
uniprot id: A0A2R9ALZ9
uniprot id: A0A2R9AMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9597:PATL2
gene id: 9597:PATL2
uniprot id: A0A2R8ZDH6
names: Similarity
messages: Belongs to the PAT1 family.

9597:FABP2
gene id: 9597:FABP2
uniprot id: A0A2R8ZM56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9597:PTPRG
gene id: 9597:PTPRG
uniprot id: A0A2R9BDA7
uniprot id: A0A2R9BLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9597:PPP3CA
gene id: 9597:PPP3CA
uniprot id: A0A2R9CDE3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9597:SLC19A3
gene id: 9597:SLC19A3
uniprot id: A0A2R9CBJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

9597:KPNA6
gene id: 9597:KPNA6
uniprot id: A0A2R8ZHT3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9597:ZNF398
gene id: 9597:ZNF398
uniprot id: A0A2R8ZUC4
names: Function
messages: May be involved in transcriptional regulation.

9597:MVB12B
gene id: 9597:MVB12B
uniprot id: A0A2R9BJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:RBBP7
gene id: 9597:RBBP7
uniprot id: A0A2R9BC22
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM135A
gene id: 9597:FAM135A
uniprot id: A0A2R9AYL5
uniprot id: A0A2R9B1Y3
uniprot id: A0A2R9B1Z4
names: Similarity
messages: Belongs to the FAM135 family.

9597:PPOX
gene id: 9597:PPOX
uniprot id: A0A2R9B4Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9597:QRSL1
gene id: 9597:QRSL1
uniprot id: A0A2R9ADE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9597:APTX
gene id: 9597:APTX
uniprot id: A0A2R9ABN2
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9597:AP4M1
gene id: 9597:AP4M1
uniprot id: A0A2R9CGR5
uniprot id: A0A2R9CGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9597:SYP
gene id: 9597:SYP
uniprot id: A0A2R9AYF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9597:HOXC10
gene id: 9597:HOXC10
uniprot id: A0A2R9B7Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9597:FAM114A2
gene id: 9597:FAM114A2
uniprot id: A0A2R8ZRS0
names: Similarity
messages: Belongs to the FAM114 family.

9597:LOC100990167
gene id: 9597:LOC100990167
uniprot id: A0A2R8Z6E1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CAPG
gene id: 9597:CAPG
uniprot id: A0A2R9BD95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9597:ZC3H14
gene id: 9597:ZC3H14
uniprot id: A0A2R9B8Q9
uniprot id: A0A2R9B8S2
uniprot id: A0A2R9BB29
uniprot id: A0A2R9BEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9597:PRLHR
gene id: 9597:PRLHR
uniprot id: A0A2R8ZDB9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:IPO7
gene id: 9597:IPO7
uniprot id: A0A2R9BTN9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:DOP1A
gene id: 9597:DOP1A
uniprot id: A0A2R9CE30
uniprot id: A0A2R9CM96
names: Similarity
messages: Belongs to the dopey family.

9597:KREMEN2
gene id: 9597:KREMEN2
uniprot id: A0A2R9CBG3
uniprot id: A0A2R9CJE4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9597:POLE2
gene id: 9597:POLE2
uniprot id: A0A2R9ATT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9597:F2R
gene id: 9597:F2R
uniprot id: A0A2R9B5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:SYPL1
gene id: 9597:SYPL1
uniprot id: A0A2R9AXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9597:LOC100968231
gene id: 9597:LOC100968231
uniprot id: A0A2R8ZES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:ARPC5
gene id: 9597:ARPC5
uniprot id: A0A2R9BWR3
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9597:ZNF26
gene id: 9597:ZNF26
uniprot id: A0A2R9CFY8
uniprot id: A0A2R9CG19
names: Function
messages: May be involved in transcriptional regulation.

9597:IL13RA2
gene id: 9597:IL13RA2
uniprot id: A0A2R9BPA3
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9597:NCEH1
gene id: 9597:NCEH1
uniprot id: A0A2R8ZF52
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9597:AVPR1B
gene id: 9597:AVPR1B
uniprot id: A0A2R9BIK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9597:REEP4
gene id: 9597:REEP4
uniprot id: A0A2R9BBT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PDHX
gene id: 9597:PDHX
uniprot id: A0A2R9ACF8
uniprot id: A0A2R9AIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9597:GPHB5
gene id: 9597:GPHB5
uniprot id: A0A2R8Z911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:INTS14
gene id: 9597:INTS14
uniprot id: A0A2R9AG12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9597:IL4
gene id: 9597:IL4
uniprot id: A0A2R8ZVJ1
uniprot id: A0A2R8ZXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9597:TMCC1
gene id: 9597:TMCC1
uniprot id: A0A2R9B4E5
names: Similarity
messages: Belongs to the TEX28 family.

9597:SMC1B
gene id: 9597:SMC1B
uniprot id: A0A2R8ZJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9597:MINDY4
gene id: 9597:MINDY4
uniprot id: A0A2R8ZGQ9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9597:TAS2R7
gene id: 9597:TAS2R7
uniprot id: Q646D6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9597:INTS7
gene id: 9597:INTS7
uniprot id: A0A2R9CGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9597:CUL1
gene id: 9597:CUL1
uniprot id: A0A2R9C048
names: Similarity
messages: Belongs to the cullin family.

9597:VPS28
gene id: 9597:VPS28
uniprot id: A0A2R9CK01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Endosome membrane
messages: Membrane

9597:PSMD7
gene id: 9597:PSMD7
uniprot id: A0A2R9BYL8
names: Similarity
messages: Belongs to the peptidase M67A family.

9597:BMP10
gene id: 9597:BMP10
uniprot id: A0A2R9CI72
names: Similarity
messages: Belongs to the TGF-beta family.

9597:SERPINB2
gene id: 9597:SERPINB2
uniprot id: A0A2R9BU70
names: Similarity
messages: Belongs to the serpin family.

9597:CXCL1
gene id: 9597:CXCL1
uniprot id: A0A2R9AI50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:EGFLAM
gene id: 9597:EGFLAM
uniprot id: A0A2R9AZ08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SLC25A42
gene id: 9597:SLC25A42
uniprot id: A0A2R9BC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ACTL10
gene id: 9597:ACTL10
uniprot id: A0A2R8ZWT6
names: Similarity
messages: Belongs to the actin family.

9597:LOC100976584
gene id: 9597:LOC100976584
uniprot id: A0A2R8ZRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:DDX58
gene id: 9597:DDX58
uniprot id: A0A2R9CAP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9597:CORO7
gene id: 9597:CORO7
uniprot id: A0A2R9BFC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9597:CHMP4A
gene id: 9597:CHMP4A
uniprot id: A0A2R9CC56
names: Similarity
messages: Belongs to the SNF7 family.

9597:LARS2
gene id: 9597:LARS2
uniprot id: A0A2R9BKK9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:SMARCA5
gene id: 9597:SMARCA5
uniprot id: A0A2R9A065
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9597:BAMBI
gene id: 9597:BAMBI
uniprot id: A0A2R8Z892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9597:LOC100982014
gene id: 9597:LOC100982014
uniprot id: A0A2R8ZRM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9597:FAM118B
gene id: 9597:FAM118B
uniprot id: A0A2R9A5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9597:SLC39A8
gene id: 9597:SLC39A8
uniprot id: A0A2R9B8F3
names: Subcellular Location Annotation
messages: Membrane

9597:ATP1B1
gene id: 9597:ATP1B1
uniprot id: A0A2R9BHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

9597:OTUB1
gene id: 9597:OTUB1
uniprot id: A0A2R8ZEY0
names: Similarity
messages: Belongs to the peptidase C65 family.

9597:TLR6
gene id: 9597:TLR6
uniprot id: B3Y642
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:VMA21
gene id: 9597:VMA21
uniprot id: A0A2R8Z5P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9597:PFDN4
gene id: 9597:PFDN4
uniprot id: A0A2R9CGH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9597:AGXT
gene id: 9597:AGXT
uniprot id: A0A2R8ZTW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9597:DDX6
gene id: 9597:DDX6
uniprot id: A0A2R9B387
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:CNOT1
gene id: 9597:CNOT1
uniprot id: A0A2R8ZLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9597:CDH5
gene id: 9597:CDH5
uniprot id: A0A2R9B8B3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9597:CBLIF
gene id: 9597:CBLIF
uniprot id: A0A2R9BIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9597:HYAL1
gene id: 9597:HYAL1
uniprot id: A0A2R9BIQ0
uniprot id: A0A2R9BRK8
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9597:LVRN
gene id: 9597:LVRN
uniprot id: A0A2R9BDU8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:ADCY9
gene id: 9597:ADCY9
uniprot id: A0A2R8ZJ01
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9597:MCF2L
gene id: 9597:MCF2L
uniprot id: A0A2R9BFA8
uniprot id: A0A2R9BFB4
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LHFPL5
gene id: 9597:LHFPL5
uniprot id: A0A2R9AIW5
names: Subcellular Location Annotation
messages: Membrane

9597:MPI
gene id: 9597:MPI
uniprot id: A0A2R9BP04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9597:GLI2
gene id: 9597:GLI2
uniprot id: A0A2R9BF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9597:ATG2A
gene id: 9597:ATG2A
uniprot id: A0A2R8ZQZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9597:FTSJ3
gene id: 9597:FTSJ3
uniprot id: A0A2R8ZT53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9597:KDM1A
gene id: 9597:KDM1A
uniprot id: A0A2R9C9V2
uniprot id: A0A2R9CA59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9597:DDRGK1
gene id: 9597:DDRGK1
uniprot id: A0A2R9AVC5
names: Similarity
messages: Belongs to the DDRGK1 family.

9597:FOXP2
gene id: 9597:FOXP2
uniprot id: Q8HZ00
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).

9597:LOC100976419
gene id: 9597:LOC100976419
uniprot id: A0A2R8ZPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9597:PDE6D
gene id: 9597:PDE6D
uniprot id: A0A2R9ACJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9597:AHCY
gene id: 9597:AHCY
uniprot id: A0A2R9BHH3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9597:CRYBA2
gene id: 9597:CRYBA2
uniprot id: A0A2R8ZH79
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:CTC1
gene id: 9597:CTC1
uniprot id: A0A2R9CCG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9597:CRCP
gene id: 9597:CRCP
uniprot id: A0A2R9AB98
uniprot id: A0A2R9ACB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9597:WARS1
gene id: 9597:WARS1
uniprot id: A0A2R9C6X6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:LOC100970314
gene id: 9597:LOC100970314
uniprot id: A0A2R8ZUG4
names: Similarity
messages: Belongs to the SNF7 family.

9597:EIF3K
gene id: 9597:EIF3K
uniprot id: A0A2R8ZTV9
uniprot id: A0A2R8ZV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9597:UBXN1
gene id: 9597:UBXN1
uniprot id: A0A2R9BG52
uniprot id: A0A2R9BKR6
names: Subcellular Location Annotation
messages: Cytoplasm

9597:FPR3
gene id: 9597:FPR3
uniprot id: A0A2R8Z8J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9597:SUV39H2
gene id: 9597:SUV39H2
uniprot id: A0A2R9AED6
uniprot id: A0A2R9AJ90
uniprot id: A0A2R9AKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9597:TBCB
gene id: 9597:TBCB
uniprot id: A0A2R9CG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9597:TOMM20L
gene id: 9597:TOMM20L
uniprot id: A0A2R9CL66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:FAM151B
gene id: 9597:FAM151B
uniprot id: A0A2R9BT92
names: Similarity
messages: Belongs to the FAM151 family.

9597:LDOC1
gene id: 9597:LDOC1
uniprot id: Q6SEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDOC1 family.
messages: Interacts with NOD2.
messages: May have an important role in the development and/or progression of some cancers.
messages: Nucleus

9597:PIH1D1
gene id: 9597:PIH1D1
uniprot id: A0A2R9BCA5
names: Similarity
messages: Belongs to the PIH1 family.

9597:TJP2
gene id: 9597:TJP2
uniprot id: A0A2R9BLV3
uniprot id: A0A2R9BLW8
uniprot id: A0A2R9BQ87
uniprot id: A0A2R9BVR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:LOC100980965
gene id: 9597:LOC100980965
uniprot id: A0A2R9BFF8
names: Similarity
messages: Belongs to the MHC class I family.

9597:ACVRL1
gene id: 9597:ACVRL1
uniprot id: A0A2R9BCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9597:PSKH1
gene id: 9597:PSKH1
uniprot id: A0A2R8ZTT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:LOC100971476
gene id: 9597:LOC100971476
uniprot id: A0A2R8ZTP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FOXF1
gene id: 9597:FOXF1
uniprot id: A0A2R9B5B5
names: Subcellular Location Annotation
messages: Nucleus

9597:MAST1
gene id: 9597:MAST1
uniprot id: A0A2R9B7I8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9597:INPP1
gene id: 9597:INPP1
uniprot id: A0A2R9BIM1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:PFDN1
gene id: 9597:PFDN1
uniprot id: A0A2R9A886
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9597:KRI1
gene id: 9597:KRI1
uniprot id: A0A2R9C8R9
names: Similarity
messages: Belongs to the KRI1 family.

9597:COPZ1
gene id: 9597:COPZ1
uniprot id: A0A2R9B038
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9597:GRIN2B
gene id: 9597:GRIN2B
uniprot id: A0A2R8ZSD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9597:PAPOLA
gene id: 9597:PAPOLA
uniprot id: A0A2R9AJ48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9597:MED18
gene id: 9597:MED18
uniprot id: A0A2R9AV56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:GPR137
gene id: 9597:GPR137
uniprot id: A0A2R9BV34
uniprot id: A0A2R9C431
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9597:IL22
gene id: 9597:IL22
uniprot id: A0A2R8ZS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9597:TM9SF4
gene id: 9597:TM9SF4
uniprot id: A0A2R9AVY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9597:CSRNP3
gene id: 9597:CSRNP3
uniprot id: A0A2R9B103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9597:LOC100996092
gene id: 9597:LOC100996092
uniprot id: A0A2R8Z7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:AP3M1
gene id: 9597:AP3M1
uniprot id: A0A2R8ZLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9597:PWP2
gene id: 9597:PWP2
uniprot id: A0A2R9BMW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9597:LOC100979614
gene id: 9597:LOC100979614
uniprot id: A0A2R8ZNV6
names: Similarity
messages: Belongs to the pro/parathymosin family.

9597:ZIC1
gene id: 9597:ZIC1
uniprot id: A0A2R9B6P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9597:PROK1
gene id: 9597:PROK1
uniprot id: A0A2R9BYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9597:KCNJ13
gene id: 9597:KCNJ13
uniprot id: A0A2R9AFS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:TMBIM4
gene id: 9597:TMBIM4
uniprot id: A0A2R9BYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:B3GNT4
gene id: 9597:B3GNT4
uniprot id: A0A2R9BTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:ERO1A
gene id: 9597:ERO1A
uniprot id: A0A2R9BD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9597:LOC100988917
gene id: 9597:LOC100988917
uniprot id: A0A2R9CC73
names: Similarity
messages: Belongs to the histone H2B family.

9597:PBX1
gene id: 9597:PBX1
uniprot id: A0A2R8ZDM5
uniprot id: A0A2R8ZJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9597:MTMR8
gene id: 9597:MTMR8
uniprot id: A0A2R8ZEM9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:WDR46
gene id: 9597:WDR46
uniprot id: A0A2R9AB91
names: Subcellular Location Annotation
messages: nucleolus

9597:CD63
gene id: 9597:CD63
uniprot id: A0A2R9C3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9597:MON2
gene id: 9597:MON2
uniprot id: A0A2R9BC32
uniprot id: A0A2R9BKE4
uniprot id: A0A2R9BKI0
names: Similarity
messages: Belongs to the MON2 family.

9597:DAD1
gene id: 9597:DAD1
uniprot id: A0A2R8ZR60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9597:SLC17A5
gene id: 9597:SLC17A5
uniprot id: A0A2R8ZTZ2
names: Subcellular Location Annotation
messages: Membrane

9597:NSF
gene id: 9597:NSF
uniprot id: A0A2R9AKP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9597:PSMD9
gene id: 9597:PSMD9
uniprot id: A0A2R9A0N0
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9597:LPAR2
gene id: 9597:LPAR2
uniprot id: A0A2R9CK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:RPS10
gene id: 9597:RPS10
uniprot id: A0A2R9C8K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9597:CYP3A4
gene id: 9597:CYP3A4
uniprot id: A0A2R9BTU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:CPEB4
gene id: 9597:CPEB4
uniprot id: A0A2R9ACA4
uniprot id: A0A2R9ACB4
uniprot id: A0A2R9AH90
uniprot id: A0A2R9AH93
names: Similarity
messages: Belongs to the RRM CPEB family.

9597:GPNMB
gene id: 9597:GPNMB
uniprot id: A0A2R9AQ34
names: Similarity
messages: Belongs to the PMEL/NMB family.

9597:AHSA1
gene id: 9597:AHSA1
uniprot id: A0A2R8ZMF0
names: Similarity
messages: Belongs to the AHA1 family.

9597:MYOD1
gene id: 9597:MYOD1
uniprot id: A0A2R9BB02
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9597:MAPK7
gene id: 9597:MAPK7
uniprot id: A0A2R9BV16
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9597:SRP19
gene id: 9597:SRP19
uniprot id: A0A2R9BEE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9597:USP27X
gene id: 9597:USP27X
uniprot id: A0A2R8ZCQ6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:LOC100978332
gene id: 9597:LOC100978332
uniprot id: A0A2R9AY18
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:ALG6
gene id: 9597:ALG6
uniprot id: A0A2R9B967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CDK3
gene id: 9597:CDK3
uniprot id: A0A2R9BSE8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:NAP1L4
gene id: 9597:NAP1L4
uniprot id: A0A2R9ALN5
uniprot id: A0A2R9ALP1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:ZBED9
gene id: 9597:ZBED9
uniprot id: A0A2R8ZQH4
names: Subcellular Location Annotation
messages: Nucleus

9597:CACNB2
gene id: 9597:CACNB2
uniprot id: A0A2R9APT0
uniprot id: A0A2R9AUD3
uniprot id: A0A2R9AUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9597:TMEM161A
gene id: 9597:TMEM161A
uniprot id: A0A2R9CJT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9597:LOC100978153
gene id: 9597:LOC100978153
uniprot id: A0A2R8ZFQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:DNMT3L
gene id: 9597:DNMT3L
uniprot id: A0A2R9C933
names: Subcellular Location Annotation
messages: Nucleus

9597:ADM
gene id: 9597:ADM
uniprot id: A0A2R8Z703
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9597:KRT72
gene id: 9597:KRT72
uniprot id: A0A2R9CPA3
names: Similarity
messages: Belongs to the intermediate filament family.

9597:IFT57
gene id: 9597:IFT57
uniprot id: A0A2R8ZS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9597:C18H18orf32
gene id: 9597:C18H18orf32
uniprot id: A0A2R8ZU84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9597:EPHB6
gene id: 9597:EPHB6
uniprot id: A0A2R9AQ56
names: Subcellular Location Annotation
messages: Membrane

9597:SAA1
gene id: 9597:SAA1
uniprot id: A0A2R9C1G3
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9597:ACAD11
gene id: 9597:ACAD11
uniprot id: A0A2R9BXK0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:AKT1
gene id: 9597:AKT1
uniprot id: A0A2R9BZ66
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9597:SDR42E1
gene id: 9597:SDR42E1
uniprot id: A0A2R9AXU6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9597:DARS2
gene id: 9597:DARS2
uniprot id: A0A2R9CJP7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9597:LIFR
gene id: 9597:LIFR
uniprot id: A0A2R9C1G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9597:LOC100993494
gene id: 9597:LOC100993494
uniprot id: A0A2R8ZDQ9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SLC5A7
gene id: 9597:SLC5A7
uniprot id: A0A2R9A7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9597:TUBB4A
gene id: 9597:TUBB4A
uniprot id: A0A2R8ZJQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:JPH3
gene id: 9597:JPH3
uniprot id: A0A2R9C555
uniprot id: A0A2R9C7Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9597:NIPSNAP3A
gene id: 9597:NIPSNAP3A
uniprot id: A0A2R9B2U7
names: Similarity
messages: Belongs to the NipSnap family.

9597:NAALADL1
gene id: 9597:NAALADL1
uniprot id: A0A2R9CKJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9597:ZACN
gene id: 9597:ZACN
uniprot id: A0A2R9BAS2
names: Subcellular Location Annotation
messages: Membrane

9597:FABP5
gene id: 9597:FABP5
uniprot id: A0A2R8ZEW7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:IL16
gene id: 9597:IL16
uniprot id: A0A2R9BD16
uniprot id: A0A2R9BED1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9597:LOC100983301
gene id: 9597:LOC100983301
uniprot id: A0A2R9AUN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9597:FLOT1
gene id: 9597:FLOT1
uniprot id: A0A2R9AGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9597:DNAJC10
gene id: 9597:DNAJC10
uniprot id: A0A2R9C0F0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9597:SLC6A17
gene id: 9597:SLC6A17
uniprot id: A0A2R9CBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:RNASEH1
gene id: 9597:RNASEH1
uniprot id: A0A2R9AXK0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9597:SNAP25
gene id: 9597:SNAP25
uniprot id: A0A2R9A2V1
uniprot id: A0A2R9A2V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9597:LOC100975788
gene id: 9597:LOC100975788
uniprot id: A0A2R8ZHA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MASTL
gene id: 9597:MASTL
uniprot id: A0A2R9BTF3
uniprot id: A0A2R9BWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9597:UST
gene id: 9597:UST
uniprot id: A0A2R8ZVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9597:TCEA1
gene id: 9597:TCEA1
uniprot id: A0A2R8ZA45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9597:FXYD4
gene id: 9597:FXYD4
uniprot id: A0A2R8ZI07
names: Similarity
messages: Belongs to the FXYD family.

9597:RRH
gene id: 9597:RRH
uniprot id: A0A2R9C7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:LPGAT1
gene id: 9597:LPGAT1
uniprot id: A0A2R9AXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:EXOC8
gene id: 9597:EXOC8
uniprot id: A0A2R8Z9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9597:NAF1
gene id: 9597:NAF1
uniprot id: A0A2R9B4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9597:YPEL2
gene id: 9597:YPEL2
uniprot id: A0A2R9ASV6
names: Similarity
messages: Belongs to the yippee family.

9597:KCNJ2
gene id: 9597:KCNJ2
uniprot id: A0A2R8ZA76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane

9597:TRAPPC1
gene id: 9597:TRAPPC1
uniprot id: A0A2R9A9B1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9597:SEMA3E
gene id: 9597:SEMA3E
uniprot id: A0A2R9A876
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CREB1
gene id: 9597:CREB1
uniprot id: A0A2R9CEL5
uniprot id: A0A2R9CPF8
names: Subcellular Location Annotation
messages: Nucleus

9597:SNCA
gene id: 9597:SNCA
uniprot id: P61144
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9597:RPS23
gene id: 9597:RPS23
uniprot id: A0A2R9CFP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9597:FAM120B
gene id: 9597:FAM120B
uniprot id: A0A2R8ZIG7
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9597:CYP46A1
gene id: 9597:CYP46A1
uniprot id: A0A2R9B9R6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:NCK2
gene id: 9597:NCK2
uniprot id: A0A2R9BIN4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9597:FUNDC1
gene id: 9597:FUNDC1
uniprot id: A0A2R9ACQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9597:PEA15
gene id: 9597:PEA15
uniprot id: A0A2R9A7G9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:CFAP52
gene id: 9597:CFAP52
uniprot id: A0A2R9B4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9597:PISD
gene id: 9597:PISD
uniprot id: A0A2R9C6P1
uniprot id: A0A2R9CH99
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9597:ACOT13
gene id: 9597:ACOT13
uniprot id: A0A2R8ZZQ2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9597:LOC100980598
gene id: 9597:LOC100980598
uniprot id: A0A2R9B2Z6
uniprot id: A0A2R9B9K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9597:SARS2
gene id: 9597:SARS2
uniprot id: A0A2R9BM96
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9597:CALB2
gene id: 9597:CALB2
uniprot id: A0A2R9CAC0
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9597:ENPP3
gene id: 9597:ENPP3
uniprot id: A0A2R8ZBQ0
names: Subcellular Location Annotation
messages: Secreted

9597:MYO1A
gene id: 9597:MYO1A
uniprot id: A0A2R9ATR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:LOC103786747
gene id: 9597:LOC103786747
uniprot id: A0A2R9AF17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9597:ABCB6
gene id: 9597:ABCB6
uniprot id: A0A2R9AJX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

9597:ITGB6
gene id: 9597:ITGB6
uniprot id: A0A2R9C494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9597:LOC100987460
gene id: 9597:LOC100987460
uniprot id: A0A2R8ZCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TACR1
gene id: 9597:TACR1
uniprot id: A0A2R8ZV24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9597:ZDHHC17
gene id: 9597:ZDHHC17
uniprot id: A0A2R9AAL1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:LSM3
gene id: 9597:LSM3
uniprot id: A0A2R9AX57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9597:IL18R1
gene id: 9597:IL18R1
uniprot id: A0A2R9BFV9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:CFAP45
gene id: 9597:CFAP45
uniprot id: A0A2R9B7G7
names: Similarity
messages: Belongs to the CFAP45 family.

9597:LCN8
gene id: 9597:LCN8
uniprot id: A0A2R9BBZ7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9597:ATG13
gene id: 9597:ATG13
uniprot id: A0A2R9CLU2
uniprot id: A0A2R9CLU8
uniprot id: A0A2R9CLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9597:OAZ1
gene id: 9597:OAZ1
uniprot id: A0A2R9B0A3
names: Similarity
messages: Belongs to the ODC antizyme family.

9597:KCNJ8
gene id: 9597:KCNJ8
uniprot id: A0A2R9BZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:SPOP
gene id: 9597:SPOP
uniprot id: A0A2R8ZSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9597:GFAP
gene id: 9597:GFAP
uniprot id: A0A2R9CBF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

9597:WNT11
gene id: 9597:WNT11
uniprot id: A0A2R8ZIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:CAPN6
gene id: 9597:CAPN6
uniprot id: A0A2R8ZZK0
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PIGC
gene id: 9597:PIGC
uniprot id: A0A2R8ZMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9597:LOC100987164
gene id: 9597:LOC100987164
uniprot id: A0A2R9BJ63
names: Similarity
messages: Belongs to the SKP1 family.

9597:SNRPA
gene id: 9597:SNRPA
uniprot id: A0A2R9AYG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9597:LRP1
gene id: 9597:LRP1
uniprot id: A0A2R9A7D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MS4A3
gene id: 9597:MS4A3
uniprot id: A0A2R9BFU4
uniprot id: A0A2R9BN34
names: Similarity
messages: Belongs to the MS4A family.

9597:LDAH
gene id: 9597:LDAH
uniprot id: A0A2R8ZM82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9597:LOC100989257
gene id: 9597:LOC100989257
uniprot id: A0A2R9BK82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9597:GCNT3
gene id: 9597:GCNT3
uniprot id: A0A2R8ZFN8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9597:IFI35
gene id: 9597:IFI35
uniprot id: A0A2R9A9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:S100A16
gene id: 9597:S100A16
uniprot id: A0A2R9CD60
names: Similarity
messages: Belongs to the S-100 family.

9597:SCN3A
gene id: 9597:SCN3A
uniprot id: A0A2R8ZIK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9597:FRAS1
gene id: 9597:FRAS1
uniprot id: A0A2R9C9U7
names: Similarity
messages: Belongs to the FRAS1 family.

9597:SLC39A14
gene id: 9597:SLC39A14
uniprot id: A0A2R8Z750
uniprot id: A0A2R8ZDH0
names: Subcellular Location Annotation
messages: Membrane

9597:STARD13
gene id: 9597:STARD13
uniprot id: A0A2R9BNF4
uniprot id: A0A2R9BNJ2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:DDIT4L
gene id: 9597:DDIT4L
uniprot id: A0A2R8ZQW6
names: Similarity
messages: Belongs to the DDIT4 family.

9597:PKIA
gene id: 9597:PKIA
uniprot id: A0A2R8ZIM0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:HLF
gene id: 9597:HLF
uniprot id: A0A2R8ZWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9597:PLBD2
gene id: 9597:PLBD2
uniprot id: A0A2R8ZXD7
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9597:IDH1
gene id: 9597:IDH1
uniprot id: A0A2R9BW49
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9597:CACNA2D1
gene id: 9597:CACNA2D1
uniprot id: A0A2R8ZS28
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9597:RNASE2
gene id: 9597:RNASE2
uniprot id: A0A2R9AR08
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:NDUFB11
gene id: 9597:NDUFB11
uniprot id: A0A2R9B427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:NDUFA5
gene id: 9597:NDUFA5
uniprot id: A0A2R9CJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:MPC1L
gene id: 9597:MPC1L
uniprot id: A0A2R8ZL99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ADAM9
gene id: 9597:ADAM9
uniprot id: A0A2R9AIT1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:POFUT1
gene id: 9597:POFUT1
uniprot id: A0A2R9BCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9597:PFDN2
gene id: 9597:PFDN2
uniprot id: A0A2R9AYJ1
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9597:HUS1B
gene id: 9597:HUS1B
uniprot id: A0A2R8ZKZ4
names: Similarity
messages: Belongs to the HUS1 family.

9597:ILVBL
gene id: 9597:ILVBL
uniprot id: A0A2R9AGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9597:RPL32
gene id: 9597:RPL32
uniprot id: A0A2R8ZDY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9597:ATRNL1
gene id: 9597:ATRNL1
uniprot id: A0A2R9AYS8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NMUR2
gene id: 9597:NMUR2
uniprot id: A0A2R8ZQR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9597:MAOB
gene id: 9597:MAOB
uniprot id: A0A2R9AU54
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9597:PHKA1
gene id: 9597:PHKA1
uniprot id: A0A2R9CAS6
uniprot id: A0A2R9CAX2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9597:MDFI
gene id: 9597:MDFI
uniprot id: A0A2R9BJQ2
uniprot id: A0A2R9BNA6
names: Similarity
messages: Belongs to the MDFI family.

9597:CLDN16
gene id: 9597:CLDN16
uniprot id: A0A2R9AJ88
uniprot id: A0A2R9AN64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:CPT1B
gene id: 9597:CPT1B
uniprot id: A0A2R8ZN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:ZNF165
gene id: 9597:ZNF165
uniprot id: A0A2R9ASP6
names: Subcellular Location Annotation
messages: Nucleus

9597:DLD
gene id: 9597:DLD
uniprot id: A0A2R9AX27
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9597:NCOA3
gene id: 9597:NCOA3
uniprot id: A0A2R9AXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9597:EPG5
gene id: 9597:EPG5
uniprot id: A0A2R8ZVN4
names: Similarity
messages: Belongs to the EPG5 family.

9597:CD59
gene id: 9597:CD59
uniprot id: A0A2R9BGD4
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

9597:GABRA5
gene id: 9597:GABRA5
uniprot id: A0A2R9BFW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:ACSF2
gene id: 9597:ACSF2
uniprot id: A0A2R9CAF0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:SLC17A7
gene id: 9597:SLC17A7
uniprot id: A0A2R9CBP1
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100986779
gene id: 9597:LOC100986779
uniprot id: A0A2R8ZLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PAEP
gene id: 9597:PAEP
uniprot id: A0A2R9AU61
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9597:TIPIN
gene id: 9597:TIPIN
uniprot id: A0A2R9AZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9597:GPRC6A
gene id: 9597:GPRC6A
uniprot id: A0A2R9APW7
uniprot id: A0A2R9APX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:EIF3I
gene id: 9597:EIF3I
uniprot id: A0A2R9ADB9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9597:NLE1
gene id: 9597:NLE1
uniprot id: A0A2R9AJ97
names: Subcellular Location Annotation
messages: nucleolus

9597:DNAJA2
gene id: 9597:DNAJA2
uniprot id: A0A2R8ZGS7
names: Subcellular Location Annotation
messages: Membrane

9597:SPTBN2
gene id: 9597:SPTBN2
uniprot id: A0A2R9A0X1
names: Similarity
messages: Belongs to the spectrin family.

9597:PPP1R1B
gene id: 9597:PPP1R1B
uniprot id: A0A2R9A0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9597:VTI1B
gene id: 9597:VTI1B
uniprot id: A0A2R8ZP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9597:ETV7
gene id: 9597:ETV7
uniprot id: A0A2R8ZLH3
uniprot id: A0A2R8ZPP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:XPO1
gene id: 9597:XPO1
uniprot id: A0A2R9AC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9597:ZNF157
gene id: 9597:ZNF157
uniprot id: A0A2R9CKQ3
names: Function
messages: May be involved in transcriptional regulation.

9597:PSMD6
gene id: 9597:PSMD6
uniprot id: A0A2R8ZEJ3
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

9597:NOP56
gene id: 9597:NOP56
uniprot id: A0A2R8ZU94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9597:LRRC42
gene id: 9597:LRRC42
uniprot id: A0A2R9BFS4
names: Similarity
messages: Belongs to the LRRC42 family.

9597:LOXL1
gene id: 9597:LOXL1
uniprot id: A0A2R9AG59
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:RPL23A
gene id: 9597:RPL23A
uniprot id: A0A2R9A5I1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9597:AQP2
gene id: 9597:AQP2
uniprot id: A0A2R9CFL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:CPSF3
gene id: 9597:CPSF3
uniprot id: A0A2R9CMZ9
names: Subcellular Location Annotation
messages: Nucleus

9597:MRPL1
gene id: 9597:MRPL1
uniprot id: A0A2R9C628
names: Subcellular Location Annotation
messages: Mitochondrion

9597:GSTZ1
gene id: 9597:GSTZ1
uniprot id: A0A2R9C487
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9597:EXOC1
gene id: 9597:EXOC1
uniprot id: A0A2R9CKU7
uniprot id: A0A2R9CKW5
uniprot id: A0A2R9CN68
names: Similarity
messages: Belongs to the SEC3 family.

9597:LOC100995326
gene id: 9597:LOC100995326
uniprot id: A0A2R9AG50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9597:LOC100974335
gene id: 9597:LOC100974335
uniprot id: A0A2R8ZAV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CSGALNACT1
gene id: 9597:CSGALNACT1
uniprot id: A0A2R8ZH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:FAM102B
gene id: 9597:FAM102B
uniprot id: A0A2R9BI51
names: Similarity
messages: Belongs to the FAM102 family.

9597:PTAR1
gene id: 9597:PTAR1
uniprot id: A0A2R8ZXR4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9597:CCDC58
gene id: 9597:CCDC58
uniprot id: A0A2R8ZZ87
names: Similarity
messages: Belongs to the MIX23 family.

9597:FABP3
gene id: 9597:FABP3
uniprot id: A0A2R9A8D8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:PLPBP
gene id: 9597:PLPBP
uniprot id: A0A2R9BH12
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9597:TGS1
gene id: 9597:TGS1
uniprot id: A0A2R9BRR3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9597:IPO8
gene id: 9597:IPO8
uniprot id: A0A2R9CAE9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:MRPL11
gene id: 9597:MRPL11
uniprot id: A0A2R9A3R3
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9597:CHD7
gene id: 9597:CHD7
uniprot id: A0A2R9ASX4
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9597:AKAP4
gene id: 9597:AKAP4
uniprot id: A0A2R9B4P4
names: Similarity
messages: Belongs to the AKAP110 family.

9597:LYG2
gene id: 9597:LYG2
uniprot id: A0A2R9ASR8
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9597:MYD88
gene id: 9597:MYD88
uniprot id: A0A2R9BKV0
uniprot id: B3Y679
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9597:METTL3
gene id: 9597:METTL3
uniprot id: A0A2R9BRP7
names: Similarity
messages: Belongs to the MT-A70-like family.

9597:VAMP1
gene id: 9597:VAMP1
uniprot id: A0A2R9B198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:THBD
gene id: 9597:THBD
uniprot id: A0A2R8ZHT7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9597:GNGT1
gene id: 9597:GNGT1
uniprot id: A0A2R8ZV08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:MZF1
gene id: 9597:MZF1
uniprot id: A0A2R9ACI4
names: Subcellular Location Annotation
messages: Nucleus

9597:PSD2
gene id: 9597:PSD2
uniprot id: A0A2R9BVI8
names: Subcellular Location Annotation
messages: ruffle membrane

9597:DYSF
gene id: 9597:DYSF
uniprot id: A0A2R9B7D1
uniprot id: A0A2R9BB58
uniprot id: A0A2R9BB65
uniprot id: A0A2R9BB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:B3GNT3
gene id: 9597:B3GNT3
uniprot id: A0A2R9BUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:NEDD9
gene id: 9597:NEDD9
uniprot id: A0A2R9A1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9597:RPIA
gene id: 9597:RPIA
uniprot id: A0A2R9CP46
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9597:TMEM106C
gene id: 9597:TMEM106C
uniprot id: A0A2R9ABZ6
names: Similarity
messages: Belongs to the TMEM106 family.

9597:CPSF4
gene id: 9597:CPSF4
uniprot id: A0A2R9CR90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9597:OLFM2
gene id: 9597:OLFM2
uniprot id: A0A2R9CHF1
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9597:METAP2
gene id: 9597:METAP2
uniprot id: A0A2R9C140
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9597:MRPL47
gene id: 9597:MRPL47
uniprot id: A0A2R8ZX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9597:LRRC8A
gene id: 9597:LRRC8A
uniprot id: A0A2R9CN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9597:BARHL2
gene id: 9597:BARHL2
uniprot id: A0A2R9B1X9
names: Subcellular Location Annotation
messages: Nucleus

9597:RSBN1
gene id: 9597:RSBN1
uniprot id: A0A2R9A297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9597:GMPPA
gene id: 9597:GMPPA
uniprot id: A0A2R8ZVG0
uniprot id: A0A2R8ZVG5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9597:FAM98B
gene id: 9597:FAM98B
uniprot id: A0A2R9BM14
names: Similarity
messages: Belongs to the FAM98 family.

9597:UCN
gene id: 9597:UCN
uniprot id: A0A2R8Z9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9597:REXO4
gene id: 9597:REXO4
uniprot id: A0A2R8ZWM2
names: Similarity
messages: Belongs to the REXO4 family.

9597:GDAP1L1
gene id: 9597:GDAP1L1
uniprot id: A0A2R9AUH4
names: Similarity
messages: Belongs to the GST superfamily.

9597:CMTM6
gene id: 9597:CMTM6
uniprot id: A0A2R9B108
names: Subcellular Location Annotation
messages: Membrane

9597:PSENEN
gene id: 9597:PSENEN
uniprot id: A0A2R9APY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9597:BAIAP2
gene id: 9597:BAIAP2
uniprot id: A0A2R8ZTG1
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9597:GGT6
gene id: 9597:GGT6
uniprot id: A0A2R9BVE5
uniprot id: A0A2R9BY67
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9597:PPP1CC
gene id: 9597:PPP1CC
uniprot id: A0A2R9AE39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9597:MID1IP1
gene id: 9597:MID1IP1
uniprot id: A0A2R8ZB72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9597:EMP1
gene id: 9597:EMP1
uniprot id: A0A2R9AAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9597:CDK9
gene id: 9597:CDK9
uniprot id: A0A2R9B5G9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ADGRL4
gene id: 9597:ADGRL4
uniprot id: A0A2R9CMJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:DNAJC27
gene id: 9597:DNAJC27
uniprot id: A0A2R9ANF0
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9597:IWS1
gene id: 9597:IWS1
uniprot id: A0A2R9C5I5
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100974064
gene id: 9597:LOC100974064
uniprot id: A0A2R9C3U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9597:APLNR
gene id: 9597:APLNR
uniprot id: A0A2R8Z9F6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:OXCT1
gene id: 9597:OXCT1
uniprot id: A0A2R8ZA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9597:TAP1
gene id: 9597:TAP1
uniprot id: A0A2R9A6J2
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9597:SEC23B
gene id: 9597:SEC23B
uniprot id: A0A2R8ZQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:LOC100973708
gene id: 9597:LOC100973708
uniprot id: A0A2R8ZEA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TCTN2
gene id: 9597:TCTN2
uniprot id: A0A2R8ZT19
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9597:ST6GALNAC5
gene id: 9597:ST6GALNAC5
uniprot id: A0A2R8ZNL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:FANCM
gene id: 9597:FANCM
uniprot id: A0A2R9A3N5
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9597:KEF42 p04
gene id: 9597:KEF42_p04
uniprot id: E0XIA4
uniprot id: Q9T9W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9597:STAMBP
gene id: 9597:STAMBP
uniprot id: A0A2R8ZEM7
names: Similarity
messages: Belongs to the peptidase M67C family.

9597:SLC25A44
gene id: 9597:SLC25A44
uniprot id: A0A2R8ZWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ENGASE
gene id: 9597:ENGASE
uniprot id: A0A2R9C2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9597:MRGPRX1
gene id: 9597:MRGPRX1
uniprot id: A0A2R8ZJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:SPX
gene id: 9597:SPX
uniprot id: A0A2R9A851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9597:SEMA4D
gene id: 9597:SEMA4D
uniprot id: A0A2R8Z765
uniprot id: A0A2R8Z782
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DNAAF4
gene id: 9597:DNAAF4
uniprot id: A0A2R8ZE43
uniprot id: A0A2R8ZHP6
uniprot id: Q863A6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with ZMYND10 (By similarity). Interacts with STUB1 (By similarity). Interacts with ESR1 and ESR2. Interacts with DNAAF2 (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (By similarity). Interacts with DNAAF6/PIH1D3 (By similarity).
messages: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).
messages: Nucleus
messages: neuron projection

9597:LOC100969759
gene id: 9597:LOC100969759
uniprot id: A0A2R8ZTU5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:INSIG1
gene id: 9597:INSIG1
uniprot id: A0A2R9BF15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9597:CXCL12
gene id: 9597:CXCL12
uniprot id: A0A2R9C2C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:ALDH2
gene id: 9597:ALDH2
uniprot id: A0A2R8ZCP2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:TAPT1
gene id: 9597:TAPT1
uniprot id: A0A2R8ZVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9597:INTS9
gene id: 9597:INTS9
uniprot id: A0A2R9C9U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9597:MC4R
gene id: 9597:MC4R
uniprot id: C3U0E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9597:NDUFB3
gene id: 9597:NDUFB3
uniprot id: A0A2R9C357
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9597:CCNI
gene id: 9597:CCNI
uniprot id: A0A2R9C8T1
names: Similarity
messages: Belongs to the cyclin family.

9597:MOCS1
gene id: 9597:MOCS1
uniprot id: A0A2R9CEX6
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9597:TSHZ3
gene id: 9597:TSHZ3
uniprot id: A0A2R9BA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9597:FOXP4
gene id: 9597:FOXP4
uniprot id: A0A2R9C2Q7
names: Subcellular Location Annotation
messages: Nucleus

9597:YDJC
gene id: 9597:YDJC
uniprot id: A0A2R9BHB6
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9597:TGIF2LX
gene id: 9597:TGIF2LX
uniprot id: A1YGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: May have a transcription role in testis.
messages: Nucleus

9597:RPRD1A
gene id: 9597:RPRD1A
uniprot id: A0A2R8ZVE1
uniprot id: A0A2R8ZWL3
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9597:CDR2L
gene id: 9597:CDR2L
uniprot id: A0A2R9C5B2
names: Similarity
messages: Belongs to the CDR2 family.

9597:LEPR
gene id: 9597:LEPR
uniprot id: A0A2R9B1D1
uniprot id: A0A2R9B1D7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9597:SELENBP1
gene id: 9597:SELENBP1
uniprot id: A0A2R9CG66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9597:PIK3IP1
gene id: 9597:PIK3IP1
uniprot id: A0A2R9A0C3
uniprot id: A0A2R9A4N9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PITHD1
gene id: 9597:PITHD1
uniprot id: A0A2R9AD35
names: Similarity
messages: Belongs to the PITHD1 family.

9597:RIMKLA
gene id: 9597:RIMKLA
uniprot id: A0A2R9AR13
names: Similarity
messages: Belongs to the RimK family.

9597:DCAF11
gene id: 9597:DCAF11
uniprot id: A0A2R9BTA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9597:MAPK1IP1L
gene id: 9597:MAPK1IP1L
uniprot id: A0A2R8ZYD7
names: Similarity
messages: Belongs to the MISS family.

9597:ABITRAM
gene id: 9597:ABITRAM
uniprot id: A0A2R9A253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9597:AKR1C4
gene id: 9597:AKR1C4
uniprot id: A0A2R9AMJ4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:TMEM168
gene id: 9597:TMEM168
uniprot id: A0A2R9CB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9597:TYRO3
gene id: 9597:TYRO3
uniprot id: A0A2R9BVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9597:ARRDC2
gene id: 9597:ARRDC2
uniprot id: A0A2R9AGZ1
names: Similarity
messages: Belongs to the arrestin family.

9597:LOC100969613
gene id: 9597:LOC100969613
uniprot id: A0A2R8ZER1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PPP6R1
gene id: 9597:PPP6R1
uniprot id: A0A2R9B9W9
names: Similarity
messages: Belongs to the SAPS family.

9597:IPMK
gene id: 9597:IPMK
uniprot id: A0A2R8ZTN4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9597:TMEM147
gene id: 9597:TMEM147
uniprot id: A0A2R9BXH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:FAM161A
gene id: 9597:FAM161A
uniprot id: A0A2R9BGS1
uniprot id: A0A2R9BGS6
names: Similarity
messages: Belongs to the FAM161 family.

9597:FZD5
gene id: 9597:FZD5
uniprot id: A0A2R8ZA02
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HOXC11
gene id: 9597:HOXC11
uniprot id: A0A2R9CK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9597:NRF1
gene id: 9597:NRF1
uniprot id: A0A2R9BZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9597:TULP4
gene id: 9597:TULP4
uniprot id: A0A2R9BSP4
names: Similarity
messages: Belongs to the TUB family.

9597:CDA
gene id: 9597:CDA
uniprot id: A0A2R9C9Q5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9597:PPP1R3B
gene id: 9597:PPP1R3B
uniprot id: A0A2R9AP01
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9597:TNKS2
gene id: 9597:TNKS2
uniprot id: A0A2R9BZG6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:LOC100976806
gene id: 9597:LOC100976806
uniprot id: A0A2R8ZBD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:NLGN1
gene id: 9597:NLGN1
uniprot id: A0A2R9A9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9597:LOC100991861
gene id: 9597:LOC100991861
uniprot id: A0A2R8Z736
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:RDX
gene id: 9597:RDX
uniprot id: A0A2R9C1K1
uniprot id: A0A2R9C4M0
uniprot id: A0A2R9CBT7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:IFIH1
gene id: 9597:IFIH1
uniprot id: A0A2R9BSQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9597:SUCLA2
gene id: 9597:SUCLA2
uniprot id: A0A2R9BKF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9597:POLR2K
gene id: 9597:POLR2K
uniprot id: A0A2R9C346
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9597:ASB5
gene id: 9597:ASB5
uniprot id: A0A2R9B4W8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:LOC100983382
gene id: 9597:LOC100983382
uniprot id: A0A2R9APA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CFAP300
gene id: 9597:CFAP300
uniprot id: A0A2R9BP32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9597:WEE2
gene id: 9597:WEE2
uniprot id: A0A2R8ZJE5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9597:SLC30A6
gene id: 9597:SLC30A6
uniprot id: A0A2R9BLV1
uniprot id: A0A2R9BV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9597:PTH
gene id: 9597:PTH
uniprot id: A0A2R9A3P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9597:PACC1
gene id: 9597:PACC1
uniprot id: A0A2R8ZRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9597:AGT
gene id: 9597:AGT
uniprot id: A0A2R8ZSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9597:PYDC1
gene id: 9597:PYDC1
uniprot id: A0A2R8ZHA2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:FGF21
gene id: 9597:FGF21
uniprot id: A0A2R9AZE4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:RRM2
gene id: 9597:RRM2
uniprot id: A0A2R9C7C5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9597:SGCG
gene id: 9597:SGCG
uniprot id: A0A2R8ZAL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9597:FAIM2
gene id: 9597:FAIM2
uniprot id: A0A2R9CH37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:BEX5
gene id: 9597:BEX5
uniprot id: A0A2R8ZIF4
names: Similarity
messages: Belongs to the BEX family.

9597:CEP44
gene id: 9597:CEP44
uniprot id: A0A2R9AH85
uniprot id: A0A2R9AI66
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9597:SLC25A18
gene id: 9597:SLC25A18
uniprot id: A0A2R9C9V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:SLC10A3
gene id: 9597:SLC10A3
uniprot id: A0A2R9B8V5
uniprot id: A0A2R9BGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:LOC100991415
gene id: 9597:LOC100991415
uniprot id: A0A2R8ZN55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100991647
gene id: 9597:LOC100991647
uniprot id: A0A2R9CJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9597:POU4F2
gene id: 9597:POU4F2
uniprot id: A0A2R9B3T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:MRPL17
gene id: 9597:MRPL17
uniprot id: A0A2R9BT89
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9597:RMND1
gene id: 9597:RMND1
uniprot id: A0A2R9B6V6
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9597:OVCA2
gene id: 9597:OVCA2
uniprot id: A0A2R9C6Z8
names: Similarity
messages: Belongs to the LovG family.

9597:ADD2
gene id: 9597:ADD2
uniprot id: A0A2R9AWM8
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9597:HSPA5
gene id: 9597:HSPA5
uniprot id: A0A2R9CFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

9597:ADRA1A
gene id: 9597:ADRA1A
uniprot id: A0A2R9CKI0
uniprot id: A0A2R9CSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9597:ENPP4
gene id: 9597:ENPP4
uniprot id: A0A2R9ALU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9597:CYP2S1
gene id: 9597:CYP2S1
uniprot id: A0A2R9AFV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:FABP9
gene id: 9597:FABP9
uniprot id: A0A2R9APN4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:BID
gene id: 9597:BID
uniprot id: A0A2R9A786
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:GNG7
gene id: 9597:GNG7
uniprot id: A0A2R9BDV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:CALHM3
gene id: 9597:CALHM3
uniprot id: A0A2R8ZAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:ZNF619
gene id: 9597:ZNF619
uniprot id: A0A2R9B7B8
names: Function
messages: May be involved in transcriptional regulation.

9597:CRYBG1
gene id: 9597:CRYBG1
uniprot id: A0A2R9AHZ4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:GAS8
gene id: 9597:GAS8
uniprot id: A0A2R8Z7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9597:TMEM233
gene id: 9597:TMEM233
uniprot id: A0A2R9A5H0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:PDE7A
gene id: 9597:PDE7A
uniprot id: A0A2R9BMV2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:FNTB
gene id: 9597:FNTB
uniprot id: A0A2R9AQT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9597:LOC100978251
gene id: 9597:LOC100978251
uniprot id: A0A2R8Z9X5
uniprot id: A0A2R9BUC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Belongs to the polypeptide deformylase family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9597:TECR
gene id: 9597:TECR
uniprot id: A0A2R9AIJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RTN4IP1
gene id: 9597:RTN4IP1
uniprot id: A0A2R9AN49
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9597:MRPL46
gene id: 9597:MRPL46
uniprot id: A0A2R9C178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9597:TMEM170B
gene id: 9597:TMEM170B
uniprot id: A0A2R9AXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9597:SMIM5
gene id: 9597:SMIM5
uniprot id: A0A2R9B3M0
names: Subcellular Location Annotation
messages: Membrane

9597:KCNK13
gene id: 9597:KCNK13
uniprot id: A0A2R9C9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:ASB9
gene id: 9597:ASB9
uniprot id: A0A2R9CJ65
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:EEF1A1
gene id: 9597:EEF1A1
uniprot id: A0A2R9BYN3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9597:MAP3K12
gene id: 9597:MAP3K12
uniprot id: A0A2R9C1I8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9597:MRPS7
gene id: 9597:MRPS7
uniprot id: A0A2R8ZN53
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9597:TPD52L3
gene id: 9597:TPD52L3
uniprot id: A0A2R9AS45
names: Similarity
messages: Belongs to the TPD52 family.

9597:RPS6KA1
gene id: 9597:RPS6KA1
uniprot id: A0A2R9C519
uniprot id: A0A2R9C536
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:ZNF251
gene id: 9597:ZNF251
uniprot id: A0A2R8ZAD2
names: Function
messages: May be involved in transcriptional regulation.

9597:CHRD
gene id: 9597:CHRD
uniprot id: A0A2R9B5W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Secreted

9597:NOP14
gene id: 9597:NOP14
uniprot id: A0A2R9BLU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9597:ARPC2
gene id: 9597:ARPC2
uniprot id: A0A2R9BBC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9597:JRKL
gene id: 9597:JRKL
uniprot id: A0A2R8ZRX1
names: Subcellular Location Annotation
messages: Nucleus

9597:PDIK1L
gene id: 9597:PDIK1L
uniprot id: A0A2R8ZKW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TOP3B
gene id: 9597:TOP3B
uniprot id: A0A2R9BLW1
uniprot id: A0A2R9BLW2
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9597:LOC100976988
gene id: 9597:LOC100976988
uniprot id: A0A2R8ZPB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MTRNR2L7
gene id: 9597:MTRNR2L7
uniprot id: A0A2R8ZI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9597:LOC100980458
gene id: 9597:LOC100980458
uniprot id: A0A2R9ALI7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9597:GBP6
gene id: 9597:GBP6
uniprot id: A0A2R9B0K8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:EXOSC3
gene id: 9597:EXOSC3
uniprot id: A0A2R9A844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9597:MRPS25
gene id: 9597:MRPS25
uniprot id: A0A2R9BU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9597:ARRB2
gene id: 9597:ARRB2
uniprot id: A0A2R9BT61
uniprot id: A0A2R9BT67
uniprot id: A0A2R9BWL3
names: Similarity
messages: Belongs to the arrestin family.

9597:FYN
gene id: 9597:FYN
uniprot id: A0A2R9B759
uniprot id: A0A2R9BAX8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:GFOD2
gene id: 9597:GFOD2
uniprot id: A0A2R9AJK1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:UNC5B
gene id: 9597:UNC5B
uniprot id: A0A2R9B4C2
uniprot id: A0A2R9B5X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9597:AMPD1
gene id: 9597:AMPD1
uniprot id: A0A2R9BAW9
uniprot id: A0A2R9BD70
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9597:CLSPN
gene id: 9597:CLSPN
uniprot id: A0A2R9A3S2
uniprot id: A0A2R9A8H6
names: Subcellular Location Annotation
messages: Nucleus

9597:GAB1
gene id: 9597:GAB1
uniprot id: A0A2R9BTS6
uniprot id: A0A2R9C3B3
names: Similarity
messages: Belongs to the GAB family.

9597:CDS1
gene id: 9597:CDS1
uniprot id: A0A2R9CJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9597:LOC100976596
gene id: 9597:LOC100976596
uniprot id: A0A2R8ZCU1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SCAMP2
gene id: 9597:SCAMP2
uniprot id: A0A2R9A3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:TVP23A
gene id: 9597:TVP23A
uniprot id: A0A2R9B555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9597:KAT6B
gene id: 9597:KAT6B
uniprot id: A0A2R8ZD29
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9597:BTG4
gene id: 9597:BTG4
uniprot id: A0A2R9CQ48
names: Similarity
messages: Belongs to the BTG family.

9597:PLD3
gene id: 9597:PLD3
uniprot id: A0A2R8ZHK7
names: Similarity
messages: Belongs to the phospholipase D family.

9597:SCN3B
gene id: 9597:SCN3B
uniprot id: A0A2R9AKY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9597:GPM6A
gene id: 9597:GPM6A
uniprot id: A0A2R9CEY0
uniprot id: A0A2R9CF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9597:TBCCD1
gene id: 9597:TBCCD1
uniprot id: A0A2R9BFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9597:IL1RAPL2
gene id: 9597:IL1RAPL2
uniprot id: A0A2R9C5Y8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:RAB21
gene id: 9597:RAB21
uniprot id: A0A2R9CLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

9597:CCNDBP1
gene id: 9597:CCNDBP1
uniprot id: A0A2R9B143
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9597:TIMM21
gene id: 9597:TIMM21
uniprot id: A0A2R8ZH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9597:ATP9B
gene id: 9597:ATP9B
uniprot id: A0A2R9B240
uniprot id: A0A2R9B422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:FGF23
gene id: 9597:FGF23
uniprot id: A0A2R9AWI6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:ADAT2
gene id: 9597:ADAT2
uniprot id: A0A2R9AW33
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9597:LOC100986475
gene id: 9597:LOC100986475
uniprot id: A0A2R9C247
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:TPX2
gene id: 9597:TPX2
uniprot id: A0A2R9AHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9597:DPY30
gene id: 9597:DPY30
uniprot id: A0A2R9BZ79
names: Similarity
messages: Belongs to the dpy-30 family.

9597:PLCG1
gene id: 9597:PLCG1
uniprot id: A0A2R9APB3
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9597:SRP68
gene id: 9597:SRP68
uniprot id: A0A2R9A348
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9597:SNU13
gene id: 9597:SNU13
uniprot id: A0A2R8ZRL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9597:SGMS2
gene id: 9597:SGMS2
uniprot id: A0A2R9C4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9597:IRF2
gene id: 9597:IRF2
uniprot id: A0A2R9B110
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:LOC100971996
gene id: 9597:LOC100971996
uniprot id: A0A2R8ZQ45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100986707
gene id: 9597:LOC100986707
uniprot id: A0A2R9BUP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:TRMT61A
gene id: 9597:TRMT61A
uniprot id: A0A2R8ZZL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9597:TCEA3
gene id: 9597:TCEA3
uniprot id: A0A2R9CNL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9597:RPS8
gene id: 9597:RPS8
uniprot id: A0A2R9BHB1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9597:HAX1
gene id: 9597:HAX1
uniprot id: A0A2R9A4K5
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9597:PMPCA
gene id: 9597:PMPCA
uniprot id: A0A2R9BJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9597:FGD3
gene id: 9597:FGD3
uniprot id: A0A2R9A8E1
uniprot id: A0A2R9A912
names: Subcellular Location Annotation
messages: cytoskeleton

9597:IDO1
gene id: 9597:IDO1
uniprot id: A0A2R9A3G1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9597:C7H7orf25
gene id: 9597:C7H7orf25
uniprot id: A0A2R9C777
names: Similarity
messages: Belongs to the UPF0415 family.

9597:TRAM1
gene id: 9597:TRAM1
uniprot id: A0A2R8ZD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9597:CCNA1
gene id: 9597:CCNA1
uniprot id: A0A2R9CDL2
uniprot id: A0A2R9CNX9
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9597:PSME2
gene id: 9597:PSME2
uniprot id: A0A2R8ZA22
names: Similarity
messages: Belongs to the PA28 family.

9597:NAB1
gene id: 9597:NAB1
uniprot id: A0A2R8Z6Q9
uniprot id: A0A2R8ZD15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9597:C5H5orf24
gene id: 9597:C5H5orf24
uniprot id: A0A2R9CPD9
names: Similarity
messages: Belongs to the UPF0461 family.

9597:DCT
gene id: 9597:DCT
uniprot id: A0A2R8ZPM8
uniprot id: A0A2R8ZSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9597:NPSR1
gene id: 9597:NPSR1
uniprot id: A0A2R9CJJ0
uniprot id: A0A2R9CJJ1
uniprot id: A0A2R9CM68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ARL2
gene id: 9597:ARL2
uniprot id: A0A2R9C7Z2
uniprot id: A0A2R9CI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9597:CKM
gene id: 9597:CKM
uniprot id: A0A2R9BMI4
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9597:SLC26A5
gene id: 9597:SLC26A5
uniprot id: A0A2R9CI47
uniprot id: A0A2R9CI49
uniprot id: A0A2R9CKT3
uniprot id: A0A2R9CRI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

9597:PLA2G2A
gene id: 9597:PLA2G2A
uniprot id: A0A2R8ZCM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:LOC100977974
gene id: 9597:LOC100977974
uniprot id: A0A2R8ZKP3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:ATP6V0B
gene id: 9597:ATP6V0B
uniprot id: A0A2R9BVN4
uniprot id: A0A2R9BZ25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9597:SEC16A
gene id: 9597:SEC16A
uniprot id: A0A2R9CEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9597:STX3
gene id: 9597:STX3
uniprot id: A0A2R8ZBH3
uniprot id: A0A2R8ZBL1
uniprot id: A0A2R8ZF33
names: Similarity
messages: Belongs to the syntaxin family.

9597:LOC100969609
gene id: 9597:LOC100969609
uniprot id: A0A2R9AVQ7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9597:MTRNR2L3
gene id: 9597:MTRNR2L3
uniprot id: A0A2R9AUN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9597:DPH6
gene id: 9597:DPH6
uniprot id: A0A2R8Z9F9
uniprot id: A0A2R8ZG56
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9597:PPP2R2B
gene id: 9597:PPP2R2B
uniprot id: A0A2R9CFA8
uniprot id: A0A2R9CFB4
uniprot id: A0A2R9CI09
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:POPDC2
gene id: 9597:POPDC2
uniprot id: A0A2R9AB24
uniprot id: A0A2R9AFZ4
names: Similarity
messages: Belongs to the popeye family.

9597:MTMR2
gene id: 9597:MTMR2
uniprot id: A0A2R9CCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9597:HTATSF1
gene id: 9597:HTATSF1
uniprot id: A0A2R8ZM86
names: Similarity
messages: Belongs to the HTATSF1 family.

9597:SLC17A8
gene id: 9597:SLC17A8
uniprot id: A0A2R9CII7
names: Subcellular Location Annotation
messages: Membrane

9597:PARVG
gene id: 9597:PARVG
uniprot id: A0A2R9BC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9597:CLDN15
gene id: 9597:CLDN15
uniprot id: A0A2R9B8A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:PRMT7
gene id: 9597:PRMT7
uniprot id: A0A2R9BNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9597:LIN7C
gene id: 9597:LIN7C
uniprot id: A0A2R9B2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9597:XCL1
gene id: 9597:XCL1
uniprot id: A0A2R9CFQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9597:ING3
gene id: 9597:ING3
uniprot id: A0A2R9A2Z0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9597:NMU
gene id: 9597:NMU
uniprot id: A0A2R9BKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9597:STN1
gene id: 9597:STN1
uniprot id: A0A2R9AF72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9597:NDUFA2
gene id: 9597:NDUFA2
uniprot id: A0A2R9AAX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:MMP19
gene id: 9597:MMP19
uniprot id: A0A2R8ZFY2
names: Similarity
messages: Belongs to the peptidase M10A family.

9597:TMOD3
gene id: 9597:TMOD3
uniprot id: A0A2R9A378
names: Subcellular Location Annotation
messages: cytoskeleton

9597:CTSH
gene id: 9597:CTSH
uniprot id: A0A2R9C3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:PDIA3
gene id: 9597:PDIA3
uniprot id: A0A2R9AJW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9597:CDK14
gene id: 9597:CDK14
uniprot id: A0A2R9CE45
uniprot id: A0A2R9CEA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MDH1B
gene id: 9597:MDH1B
uniprot id: A0A2R9AHF3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9597:TAF1A
gene id: 9597:TAF1A
uniprot id: A0A2R9BPT1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9597:LOC100988170
gene id: 9597:LOC100988170
uniprot id: A0A2R9APD1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:HIF1A
gene id: 9597:HIF1A
uniprot id: A0A2R9A0V2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9597:POLR1C
gene id: 9597:POLR1C
uniprot id: A0A2R9CSD9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9597:APOA5
gene id: 9597:APOA5
uniprot id: A0A2R9C0K9
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9597:FABP4
gene id: 9597:FABP4
uniprot id: A0A2R9APP5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:SCPEP1
gene id: 9597:SCPEP1
uniprot id: A0A2R9CPC7
names: Similarity
messages: Belongs to the peptidase S10 family.

9597:LOC100977138
gene id: 9597:LOC100977138
uniprot id: A0A2R8ZAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PCSK1
gene id: 9597:PCSK1
uniprot id: A0A2R9BH22
uniprot id: A0A2R9BI06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9597:SLC25A13
gene id: 9597:SLC25A13
uniprot id: A0A2R9B4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ZNF584
gene id: 9597:ZNF584
uniprot id: A0A2R9A9Y6
names: Function
messages: May be involved in transcriptional regulation.

9597:CASP8
gene id: 9597:CASP8
uniprot id: A0A2R9AE19
uniprot id: A0A2R9AJC1
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:IRGQ
gene id: 9597:IRGQ
uniprot id: A0A2R9C798
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9597:NFRKB
gene id: 9597:NFRKB
uniprot id: A0A2R9AHT8
names: Subcellular Location Annotation
messages: Nucleus

9597:MMRN1
gene id: 9597:MMRN1
uniprot id: A0A2R9CCC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TP53
gene id: 9597:TP53
uniprot id: A0A2R9A5P4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9597:STMN1
gene id: 9597:STMN1
uniprot id: A0A2R9BTL6
uniprot id: A0A2R9BZ38
names: Similarity
messages: Belongs to the stathmin family.

9597:SLC26A1
gene id: 9597:SLC26A1
uniprot id: A0A2R9B339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
messages: Membrane

9597:RSAD1
gene id: 9597:RSAD1
uniprot id: A0A2R9BU92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

9597:RANGRF
gene id: 9597:RANGRF
uniprot id: A0A2R8ZQT8
names: Similarity
messages: Belongs to the MOG1 family.

9597:LOC100973858
gene id: 9597:LOC100973858
uniprot id: A0A2R9BU98
names: Similarity
messages: Belongs to the intermediate filament family.

9597:EZH2
gene id: 9597:EZH2
uniprot id: A0A2R9AHK6
names: Subcellular Location Annotation
messages: Nucleus

9597:PATL1
gene id: 9597:PATL1
uniprot id: A0A2R9AYS4
names: Similarity
messages: Belongs to the PAT1 family.

9597:CD70
gene id: 9597:CD70
uniprot id: A0A2R9A5Z7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:B9D2
gene id: 9597:B9D2
uniprot id: A0A2R9C9N0
names: Subcellular Location Annotation
messages: cilium basal body

9597:KHDRBS3
gene id: 9597:KHDRBS3
uniprot id: A0A2R9CT81
names: Similarity
messages: Belongs to the KHDRBS family.

9597:CYP4F2
gene id: 9597:CYP4F2
uniprot id: A0A2R8ZQU9
uniprot id: A0A2R8ZVJ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:PPIL3
gene id: 9597:PPIL3
uniprot id: A0A2R9BSM7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:LOC100968579
gene id: 9597:LOC100968579
uniprot id: A0A2R9AR25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:CLK4
gene id: 9597:CLK4
uniprot id: A0A2R9BIW2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:HEATR5A
gene id: 9597:HEATR5A
uniprot id: A0A2R9B3B7
names: Similarity
messages: Belongs to the HEATR5 family.

9597:NEURL2
gene id: 9597:NEURL2
uniprot id: A0A2R9BZQ0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PDS5B
gene id: 9597:PDS5B
uniprot id: A0A2R8Z973
names: Similarity
messages: Belongs to the PDS5 family.

9597:LSM14A
gene id: 9597:LSM14A
uniprot id: A0A2R9CDQ6
uniprot id: A0A2R9CDR2
names: Similarity
messages: Belongs to the LSM14 family.

9597:LCE3B
gene id: 9597:LCE3B
uniprot id: A0A2R8ZNN4
names: Similarity
messages: Belongs to the LCE family.

9597:LOC100982084
gene id: 9597:LOC100982084
uniprot id: A0A2R8Z858
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:GDE1
gene id: 9597:GDE1
uniprot id: A0A2R9AFK3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:CAMK2A
gene id: 9597:CAMK2A
uniprot id: A0A2R9CAT1
uniprot id: A0A2R9CAY6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9597:HSPB8
gene id: 9597:HSPB8
uniprot id: A0A2R9AWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9597:DESI2
gene id: 9597:DESI2
uniprot id: A0A2R9BD75
names: Similarity
messages: Belongs to the DeSI family.

9597:TPH2
gene id: 9597:TPH2
uniprot id: A0A2R9ACE6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9597:AP2B1
gene id: 9597:AP2B1
uniprot id: A0A2R9AN06
uniprot id: A0A2R9AN11
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:GJA5
gene id: 9597:GJA5
uniprot id: A0A2R8ZBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:PIGZ
gene id: 9597:PIGZ
uniprot id: A0A2R9C6F3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:RNF40
gene id: 9597:RNF40
uniprot id: A0A2R8ZS60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9597:GUCY1B1
gene id: 9597:GUCY1B1
uniprot id: A0A2R8ZGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9597:ZNF785
gene id: 9597:ZNF785
uniprot id: A0A2R9CSC7
names: Function
messages: May be involved in transcriptional regulation.

9597:B3GNT9
gene id: 9597:B3GNT9
uniprot id: A0A2R8ZCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:ST8SIA1
gene id: 9597:ST8SIA1
uniprot id: A0A2R9CDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LHX5
gene id: 9597:LHX5
uniprot id: A0A2R9B0Q4
names: Subcellular Location Annotation
messages: Nucleus

9597:PIAS3
gene id: 9597:PIAS3
uniprot id: A0A2R9AN48
names: Similarity
messages: Belongs to the PIAS family.

9597:FAM83B
gene id: 9597:FAM83B
uniprot id: A0A2R9A0A2
names: Similarity
messages: Belongs to the FAM83 family.

9597:LOC100978529
gene id: 9597:LOC100978529
uniprot id: A0A2R9BP16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:GNAI1
gene id: 9597:GNAI1
uniprot id: A0A2R9AFQ7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:GRPEL2
gene id: 9597:GRPEL2
uniprot id: A0A2R9AM09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9597:ADGB
gene id: 9597:ADGB
uniprot id: A0A2R9AEZ6
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PLBD1
gene id: 9597:PLBD1
uniprot id: A0A2R9AF34
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9597:CPA2
gene id: 9597:CPA2
uniprot id: A0A2R9CD62
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:OSTC
gene id: 9597:OSTC
uniprot id: A0A2R9CSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9597:PPIL2
gene id: 9597:PPIL2
uniprot id: A0A2R9AF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9597:AQP9
gene id: 9597:AQP9
uniprot id: A0A2R9CLD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:AP2M1
gene id: 9597:AP2M1
uniprot id: A0A2R9B698
uniprot id: A0A2R9B9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9597:PDGFRA
gene id: 9597:PDGFRA
uniprot id: A0A2R9AK21
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9597:PELI3
gene id: 9597:PELI3
uniprot id: A0A2R8ZVA7
uniprot id: A0A2R8ZZT0
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9597:VAX1
gene id: 9597:VAX1
uniprot id: A0A2R9A8I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9597:HSPA14
gene id: 9597:HSPA14
uniprot id: A0A2R8ZE99
uniprot id: A0A2R8ZHF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9597:GGA3
gene id: 9597:GGA3
uniprot id: A0A2R9A587
uniprot id: A0A2R9AAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9597:PSMA3
gene id: 9597:PSMA3
uniprot id: A0A2R9B530
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:GNAO1
gene id: 9597:GNAO1
uniprot id: A0A2R9C7L7
uniprot id: A0A2R9CI50
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:CA8
gene id: 9597:CA8
uniprot id: A0A2R9BI01
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9597:FAM3C
gene id: 9597:FAM3C
uniprot id: A0A2R9BJ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:IRF5
gene id: 9597:IRF5
uniprot id: A0A2R9AHU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:CCNG2
gene id: 9597:CCNG2
uniprot id: A0A2R9C0Z0
names: Similarity
messages: Belongs to the cyclin family.

9597:CARTPT
gene id: 9597:CARTPT
uniprot id: A0A2R9CBD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9597:PARD6B
gene id: 9597:PARD6B
uniprot id: A0A2R9BQ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9597:ATP23
gene id: 9597:ATP23
uniprot id: A0A2R9B683
names: Similarity
messages: Belongs to the peptidase M76 family.

9597:CD53
gene id: 9597:CD53
uniprot id: A0A2R9BVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:ASB12
gene id: 9597:ASB12
uniprot id: A0A2R9AIW6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:VIPR1
gene id: 9597:VIPR1
uniprot id: A0A2R8ZIZ6
uniprot id: A0A2R8ZM03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9597:NIM1K
gene id: 9597:NIM1K
uniprot id: A0A2R9AWS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:CD247
gene id: 9597:CD247
uniprot id: A0A2R9CQ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9597:L1CAM
gene id: 9597:L1CAM
uniprot id: A0A2R9C9W7
uniprot id: A0A2R9C9X1
uniprot id: A0A2R9CCL8
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9597:SEMA5A
gene id: 9597:SEMA5A
uniprot id: A0A2R9CRB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NFYB
gene id: 9597:NFYB
uniprot id: A0A2R9C725
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9597:ZNF735
gene id: 9597:ZNF735
uniprot id: A0A2R9AKI5
names: Function
messages: May be involved in transcriptional regulation.

9597:DISP3
gene id: 9597:DISP3
uniprot id: A0A2R9BUF0
names: Subcellular Location Annotation
messages: Membrane

9597:ZSCAN18
gene id: 9597:ZSCAN18
uniprot id: A0A2R9ALY8
names: Subcellular Location Annotation
messages: Nucleus

9597:RPLP1
gene id: 9597:RPLP1
uniprot id: A0A2R9BTM9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9597:PLA2G2D
gene id: 9597:PLA2G2D
uniprot id: A0A2R9AN17
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:MAP1LC3A
gene id: 9597:MAP1LC3A
uniprot id: A0A2R9BFU8
names: Similarity
messages: Belongs to the ATG8 family.

9597:PPP6C
gene id: 9597:PPP6C
uniprot id: A0A2R8Z8V6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9597:LYPD2
gene id: 9597:LYPD2
uniprot id: A0A2R8ZM16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:PHETA2
gene id: 9597:PHETA2
uniprot id: A0A2R8ZCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9597:RDH5
gene id: 9597:RDH5
uniprot id: A0A2R8ZEU3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:APOO
gene id: 9597:APOO
uniprot id: A0A2R9AXK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9597:RALA
gene id: 9597:RALA
uniprot id: A0A2R8Z7T7
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9597:UBAC1
gene id: 9597:UBAC1
uniprot id: A0A2R9B836
names: Subcellular Location Annotation
messages: Cytoplasm

9597:TAGLN2
gene id: 9597:TAGLN2
uniprot id: A0A2R9AVL5
names: Similarity
messages: Belongs to the calponin family.

9597:MYH2
gene id: 9597:MYH2
uniprot id: A0A2R9C3D0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:ACBD5
gene id: 9597:ACBD5
uniprot id: A0A2R9BMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9597:GALNT1
gene id: 9597:GALNT1
uniprot id: A0A2R8ZP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:SLF2
gene id: 9597:SLF2
uniprot id: A0A2R9C158
names: Similarity
messages: Belongs to the FAM178 family.

9597:DDX3X
gene id: 9597:DDX3X
uniprot id: A0A2R9C920
uniprot id: A0A2R9C951
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:SULT1B1
gene id: 9597:SULT1B1
uniprot id: A0A2R9BUA8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:LOC100982351
gene id: 9597:LOC100982351
uniprot id: A0A2R9BWJ1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9597:MRPL16
gene id: 9597:MRPL16
uniprot id: A0A2R9BS01
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9597:DLGAP1
gene id: 9597:DLGAP1
uniprot id: A0A2R9AP48
uniprot id: A0A2R9ATL5
uniprot id: A0A2R9ATN1
uniprot id: A0A2R9AW07
names: Similarity
messages: Belongs to the SAPAP family.

9597:BCL2L1
gene id: 9597:BCL2L1
uniprot id: A0A2R8Z9D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9597:AURKA
gene id: 9597:AURKA
uniprot id: A0A2R9ANX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9597:ZNF503
gene id: 9597:ZNF503
uniprot id: A0A2R8Z5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9597:LOC100982405
gene id: 9597:LOC100982405
uniprot id: A0A2R8ZCY2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LIPM
gene id: 9597:LIPM
uniprot id: A0A2R9CBQ7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:GOLGA5
gene id: 9597:GOLGA5
uniprot id: A0A2R9BM95
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9597:ATP13A3
gene id: 9597:ATP13A3
uniprot id: A0A2R9C6Q3
uniprot id: A0A2R9C6U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9597:RPS26
gene id: 9597:RPS26
uniprot id: A0A2R9BFK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9597:HS3ST2
gene id: 9597:HS3ST2
uniprot id: A0A2R9B8Q8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:UBE2F
gene id: 9597:UBE2F
uniprot id: A0A2R9C572
uniprot id: A0A2R9C5F3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:USP35
gene id: 9597:USP35
uniprot id: A0A2R9BR25
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:S100G
gene id: 9597:S100G
uniprot id: A0A2R9B678
names: Similarity
messages: Belongs to the S-100 family.

9597:TMPRSS11F
gene id: 9597:TMPRSS11F
uniprot id: A0A2R8Z9R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9597:RNFT2
gene id: 9597:RNFT2
uniprot id: A0A2R9BE12
names: Subcellular Location Annotation
messages: Membrane

9597:GPR20
gene id: 9597:GPR20
uniprot id: A0A2R8ZDI5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LPCAT4
gene id: 9597:LPCAT4
uniprot id: A0A2R9B1Q1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:MATN3
gene id: 9597:MATN3
uniprot id: A0A2R9B520
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SLC39A9
gene id: 9597:SLC39A9
uniprot id: A0A2R9AF04
uniprot id: A0A2R9AJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9597:UNC119
gene id: 9597:UNC119
uniprot id: A0A2R9C9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9597:CLU
gene id: 9597:CLU
uniprot id: A0A2R9AC29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9597:EFEMP2
gene id: 9597:EFEMP2
uniprot id: A0A2R9A1U7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ESYT3
gene id: 9597:ESYT3
uniprot id: A0A2R8ZI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:GABRG2
gene id: 9597:GABRG2
uniprot id: A0A2R9CM58
uniprot id: A0A2R9CM76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:ZSCAN25
gene id: 9597:ZSCAN25
uniprot id: A0A2R9CHA0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:LOXL4
gene id: 9597:LOXL4
uniprot id: A0A2R9AFR2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:CHIA
gene id: 9597:CHIA
uniprot id: A0A2R8ZL98
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9597:PSMA8
gene id: 9597:PSMA8
uniprot id: A0A2R8ZX05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:POLR3GL
gene id: 9597:POLR3GL
uniprot id: A0A2R9AY48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9597:RIMKLB
gene id: 9597:RIMKLB
uniprot id: A0A2R9A7I7
names: Similarity
messages: Belongs to the RimK family.

9597:ZDHHC21
gene id: 9597:ZDHHC21
uniprot id: A0A2R9BML4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:TBL1X
gene id: 9597:TBL1X
uniprot id: A0A2R9BZY4
names: Similarity
messages: Belongs to the WD repeat EBI family.

9597:ASPA
gene id: 9597:ASPA
uniprot id: A0A2R9C417
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9597:CLDN34
gene id: 9597:CLDN34
uniprot id: A0A2R8ZI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:VEPH1
gene id: 9597:VEPH1
uniprot id: A0A2R9B0V6
names: Similarity
messages: Belongs to the MELT/VEPH family.

9597:KCNJ15
gene id: 9597:KCNJ15
uniprot id: A0A2R9AKM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:PDS5A
gene id: 9597:PDS5A
uniprot id: A0A2R9BBB8
names: Similarity
messages: Belongs to the PDS5 family.

9597:SLC25A12
gene id: 9597:SLC25A12
uniprot id: A0A2R8ZPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ATAD2
gene id: 9597:ATAD2
uniprot id: A0A2R9CHR1
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:ELOC
gene id: 9597:ELOC
uniprot id: A0A2R8ZBZ5
names: Similarity
messages: Belongs to the SKP1 family.

9597:RPL28
gene id: 9597:RPL28
uniprot id: A0A2R9BTU0
uniprot id: A0A2R9BTV5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9597:UBA2
gene id: 9597:UBA2
uniprot id: A0A2R9AE16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9597:NT5E
gene id: 9597:NT5E
uniprot id: A0A2R9B776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9597:C7
gene id: 9597:C7
uniprot id: A0A2R9AUH1
uniprot id: A0A2R9AYC3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:LOC100984084
gene id: 9597:LOC100984084
uniprot id: A0A2R8ZDT2
uniprot id: A0A2R8ZHH0
names: Function
messages: May be involved in transcriptional regulation.

9597:HOXA7
gene id: 9597:HOXA7
uniprot id: A0A2R9AYE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:ADGRF2
gene id: 9597:ADGRF2
uniprot id: A0A2R9B8I2
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100994493
gene id: 9597:LOC100994493
uniprot id: A0A2R8Z791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

9597:EMG1
gene id: 9597:EMG1
uniprot id: A0A2R9AXE4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9597:DRD5
gene id: 9597:DRD5
uniprot id: A0A2R8ZLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:INSL6
gene id: 9597:INSL6
uniprot id: A0A2R8Z728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

9597:CELF3
gene id: 9597:CELF3
uniprot id: A0A2R9BSC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9597:FBLN7
gene id: 9597:FBLN7
uniprot id: A0A2R9AFX3
uniprot id: A0A2R9AMM3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:C1S
gene id: 9597:C1S
uniprot id: A0A2R9CER8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CDKN1B
gene id: 9597:CDKN1B
uniprot id: A0A2R9A797
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9597:SMAGP
gene id: 9597:SMAGP
uniprot id: A0A2R9CAH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:PACSIN1
gene id: 9597:PACSIN1
uniprot id: A0A2R8ZCS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9597:TAS2R42
gene id: 9597:TAS2R42
uniprot id: A0A2R8ZS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9597:PPP4R3B
gene id: 9597:PPP4R3B
uniprot id: A0A2R9BBC1
uniprot id: A0A2R9BEY6
names: Similarity
messages: Belongs to the SMEK family.

9597:ZNF75A
gene id: 9597:ZNF75A
uniprot id: A0A2R9A4I3
names: Function
messages: May be involved in transcriptional regulation.

9597:THY1
gene id: 9597:THY1
uniprot id: A0A2R9AEX5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9597:CADM2
gene id: 9597:CADM2
uniprot id: A0A2R9AHU7
uniprot id: A0A2R9AJ73
names: Similarity
messages: Belongs to the nectin family.

9597:RNASET2
gene id: 9597:RNASET2
uniprot id: A0A2R9AMM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9597:ATG4C
gene id: 9597:ATG4C
uniprot id: A0A2R9CGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9597:SDHAF2
gene id: 9597:SDHAF2
uniprot id: A0A2R9CGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9597:HAUS1
gene id: 9597:HAUS1
uniprot id: A0A2R9AWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9597:IL33
gene id: 9597:IL33
uniprot id: A0A2R9A3H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9597:DCTPP1
gene id: 9597:DCTPP1
uniprot id: A0A2R9B350
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9597:ZNF337
gene id: 9597:ZNF337
uniprot id: A0A2R8ZUC8
names: Function
messages: May be involved in transcriptional regulation.

9597:MCTP2
gene id: 9597:MCTP2
uniprot id: A0A2R8Z631
names: Subcellular Location Annotation
messages: Membrane

9597:POSTN
gene id: 9597:POSTN
uniprot id: A0A2R9ABE0
uniprot id: A0A2R9ABE4
uniprot id: A0A2R9ABW4
uniprot id: A0A2R9ABY3
names: Subcellular Location Annotation
messages: extracellular matrix

9597:TRUB2
gene id: 9597:TRUB2
uniprot id: A0A2R9CGK9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9597:LOC100982553
gene id: 9597:LOC100982553
uniprot id: A0A2R8ZMQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100974647
gene id: 9597:LOC100974647
uniprot id: A0A2R8ZYE4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9597:DR1
gene id: 9597:DR1
uniprot id: A0A2R8ZU21
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9597:TDO2
gene id: 9597:TDO2
uniprot id: A0A2R8ZQE8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CPT2
gene id: 9597:CPT2
uniprot id: A0A2R9BDL0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9597:DPP3
gene id: 9597:DPP3
uniprot id: A0A2R9C5K9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9597:APH1B
gene id: 9597:APH1B
uniprot id: A0A2R8ZDL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9597:CELF1
gene id: 9597:CELF1
uniprot id: A0A2R9AVQ9
uniprot id: A0A2R9AZU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9597:IQCG
gene id: 9597:IQCG
uniprot id: A0A2R9AK59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9597:TSPAN13
gene id: 9597:TSPAN13
uniprot id: A0A2R8ZDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:SLC27A1
gene id: 9597:SLC27A1
uniprot id: A0A2R9CKC4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:CHRND
gene id: 9597:CHRND
uniprot id: A0A2R9BS42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:DSCC1
gene id: 9597:DSCC1
uniprot id: A0A2R8ZGV0
names: Similarity
messages: Belongs to the DCC1 family.

9597:TMED3
gene id: 9597:TMED3
uniprot id: A0A2R9BX70
uniprot id: A0A2R9BXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:PMM2
gene id: 9597:PMM2
uniprot id: A0A2R9C751
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9597:ZNF671
gene id: 9597:ZNF671
uniprot id: A0A2R9CHI0
names: Function
messages: May be involved in transcriptional regulation.

9597:LAMC2
gene id: 9597:LAMC2
uniprot id: A0A2R9B9I9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:TMEM254
gene id: 9597:TMEM254
uniprot id: A0A2R9BGP2
uniprot id: A0A2R9BKD0
names: Subcellular Location Annotation
messages: Membrane

9597:CPLX4
gene id: 9597:CPLX4
uniprot id: A0A2R9A7Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9597:GTF2H4
gene id: 9597:GTF2H4
uniprot id: A0A2R9BWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9597:PLXNB1
gene id: 9597:PLXNB1
uniprot id: A0A2R9BNG0
uniprot id: A0A2R9BXJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CCDC153
gene id: 9597:CCDC153
uniprot id: A0A2R9BL48
names: Similarity
messages: Belongs to the UPF0610 family.

9597:SLC22A4
gene id: 9597:SLC22A4
uniprot id: A0A2R9C4N8
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9597:OLFML3
gene id: 9597:OLFML3
uniprot id: A0A2R9BK47
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:MPO
gene id: 9597:MPO
uniprot id: A0A2R9BXA8
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9597:GOLM1
gene id: 9597:GOLM1
uniprot id: A0A2R8ZYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9597:IRF1
gene id: 9597:IRF1
uniprot id: A0A2R9BBG0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:MID1
gene id: 9597:MID1
uniprot id: A0A2R9BLE9
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9597:PRKAB1
gene id: 9597:PRKAB1
uniprot id: A0A2R9AUB1
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9597:MRPL40
gene id: 9597:MRPL40
uniprot id: A0A2R9AAU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9597:IL17C
gene id: 9597:IL17C
uniprot id: A0A2R8Z6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:MAPK8
gene id: 9597:MAPK8
uniprot id: A0A2R8Z8K5
uniprot id: A0A2R8Z8R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9597:RFNG
gene id: 9597:RFNG
uniprot id: A0A2R9BSY8
names: Subcellular Location Annotation
messages: Membrane

9597:S100A2
gene id: 9597:S100A2
uniprot id: A0A2R9B689
names: Similarity
messages: Belongs to the S-100 family.

9597:TNFRSF8
gene id: 9597:TNFRSF8
uniprot id: A0A2R9AXI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DIABLO
gene id: 9597:DIABLO
uniprot id: A0A2R8ZB90
names: Subcellular Location Annotation
messages: Mitochondrion

9597:RAD1
gene id: 9597:RAD1
uniprot id: A0A2R8ZZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9597:TOR1AIP2
gene id: 9597:TOR1AIP2
uniprot id: A0A2R9BSV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9597:ITGA1
gene id: 9597:ITGA1
uniprot id: A0A2R9BDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:FREM3
gene id: 9597:FREM3
uniprot id: A0A2R9A5H1
names: Similarity
messages: Belongs to the FRAS1 family.

9597:GOT2
gene id: 9597:GOT2
uniprot id: A0A2R9CP09
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9597:CFL1
gene id: 9597:CFL1
uniprot id: A0A2R9C8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9597:MAGT1
gene id: 9597:MAGT1
uniprot id: A0A2R9BIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:STK40
gene id: 9597:STK40
uniprot id: A0A2R9BTT0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9597:PDE5A
gene id: 9597:PDE5A
uniprot id: A0A2R9CF87
uniprot id: A0A2R9CFA2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:ARL3
gene id: 9597:ARL3
uniprot id: A0A2R9B1Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9597:THYN1
gene id: 9597:THYN1
uniprot id: A0A2R8ZTM6
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9597:BMP5
gene id: 9597:BMP5
uniprot id: A0A2R8Z8H0
names: Similarity
messages: Belongs to the TGF-beta family.

9597:FAM214B
gene id: 9597:FAM214B
uniprot id: A0A2R9AZQ6
names: Similarity
messages: Belongs to the FAM214 family.

9597:SNRPD2
gene id: 9597:SNRPD2
uniprot id: A0A2R9BU17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9597:XRN1
gene id: 9597:XRN1
uniprot id: A0A2R8ZBD9
uniprot id: A0A2R8ZI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9597:PGC
gene id: 9597:PGC
uniprot id: A0A2R9CFK5
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

9597:SSTR2
gene id: 9597:SSTR2
uniprot id: A0A2R8ZAV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9597:CPPED1
gene id: 9597:CPPED1
uniprot id: A0A2R9B663
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9597:PLOD1
gene id: 9597:PLOD1
uniprot id: A0A2R9B141
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9597:ZNF662
gene id: 9597:ZNF662
uniprot id: A0A2R9CB85
names: Function
messages: May be involved in transcriptional regulation.

9597:FNBP1L
gene id: 9597:FNBP1L
uniprot id: A0A2R9A8H9
uniprot id: A0A2R9A8I9
uniprot id: A0A2R9ADU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9597:RPL5
gene id: 9597:RPL5
uniprot id: A0A2R8ZY92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9597:CDX2
gene id: 9597:CDX2
uniprot id: A0A2R9AQ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9597:TCAF1
gene id: 9597:TCAF1
uniprot id: A0A2R9CGI0
names: Similarity
messages: Belongs to the TCAF family.

9597:SUB1
gene id: 9597:SUB1
uniprot id: A0A2R8ZIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9597:TSPAN4
gene id: 9597:TSPAN4
uniprot id: A0A2R9B448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:SLC38A2
gene id: 9597:SLC38A2
uniprot id: A1YG32
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Inhibited by N-methyl-D-glucamine. Inhibited by choline. Allosteric regulation of sodium ions binding by pH.
messages: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
messages: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).
messages: The extracellular C-terminal domain controls the voltage dependence for amino acid transports activity.

9597:PAPA-C
gene id: 9597:PAPA-C
uniprot id: A0A023T6C6
names: Similarity
messages: Belongs to the MHC class I family.

9597:CASK
gene id: 9597:CASK
uniprot id: A0A2R9BZ46
uniprot id: A0A2R9C1W5
uniprot id: A0A2R9C8M8
names: Similarity
messages: Belongs to the MAGUK family.

9597:ZNF141
gene id: 9597:ZNF141
uniprot id: A0A2R8ZM32
names: Function
messages: May be involved in transcriptional regulation.

9597:KIF6
gene id: 9597:KIF6
uniprot id: A0A2R9BL69
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:FAM98A
gene id: 9597:FAM98A
uniprot id: A0A2R9BLM0
names: Similarity
messages: Belongs to the FAM98 family.

9597:MRPS33
gene id: 9597:MRPS33
uniprot id: A0A2R9CQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9597:KDM5C
gene id: 9597:KDM5C
uniprot id: A0A2R9BE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Nucleus

9597:SMARCB1
gene id: 9597:SMARCB1
uniprot id: A0A2R9A3R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9597:LIN28A
gene id: 9597:LIN28A
uniprot id: A0A2R9BMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9597:ACP5
gene id: 9597:ACP5
uniprot id: A0A2R8ZRI1
names: Cofactor
messages: Binds 2 iron ions per subunit.

9597:DAPK3
gene id: 9597:DAPK3
uniprot id: A0A2R9A7I4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:SUPV3L1
gene id: 9597:SUPV3L1
uniprot id: A0A2R9B196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9597:PKNOX2
gene id: 9597:PKNOX2
uniprot id: A0A2R9CF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9597:FXYD3
gene id: 9597:FXYD3
uniprot id: A0A2R8ZHG9
names: Similarity
messages: Belongs to the FXYD family.

9597:TARDBP
gene id: 9597:TARDBP
uniprot id: A0A2R9C1F8
names: Subcellular Location Annotation
messages: Nucleus

9597:DRAM1
gene id: 9597:DRAM1
uniprot id: A0A2R9CSQ3
names: Subcellular Location Annotation
messages: Membrane

9597:DPPA2
gene id: 9597:DPPA2
uniprot id: A0A2R8ZXS6
names: Subcellular Location Annotation
messages: Nucleus

9597:IARS2
gene id: 9597:IARS2
uniprot id: A0A2R9A7Y9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:SLC25A1
gene id: 9597:SLC25A1
uniprot id: A0A2R8Z7R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:MCM5
gene id: 9597:MCM5
uniprot id: A0A2R9C800
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9597:NR1H3
gene id: 9597:NR1H3
uniprot id: A0A2R9BV37
uniprot id: A0A2R9BV44
uniprot id: A0A2R9BV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:PKIG
gene id: 9597:PKIG
uniprot id: A0A2R9CGG5
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:ZZZ3
gene id: 9597:ZZZ3
uniprot id: A0A2R9BW28
names: Subcellular Location Annotation
messages: Nucleus

9597:PTPRM
gene id: 9597:PTPRM
uniprot id: A0A2R8ZLI9
uniprot id: A0A2R8ZRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9597:MAB21L2
gene id: 9597:MAB21L2
uniprot id: A0A2R8ZMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9597:GJA3
gene id: 9597:GJA3
uniprot id: A0A2R8ZQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:DUSP26
gene id: 9597:DUSP26
uniprot id: A0A2R9BXG4
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9597:CHRNB2
gene id: 9597:CHRNB2
uniprot id: A0A2R9AJA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:P2RY2
gene id: 9597:P2RY2
uniprot id: A0A2R8ZPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:TUBE1
gene id: 9597:TUBE1
uniprot id: A0A2R8ZTN8
uniprot id: A0A2R8ZZE4
names: Similarity
messages: Belongs to the tubulin family.

9597:FAM214A
gene id: 9597:FAM214A
uniprot id: A0A2R9BIL9
uniprot id: A0A2R9BIM4
names: Similarity
messages: Belongs to the FAM214 family.

9597:LEF1
gene id: 9597:LEF1
uniprot id: A0A2R9CF20
uniprot id: A0A2R9CPR7
uniprot id: A0A2R9CPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9597:TLCD5
gene id: 9597:TLCD5
uniprot id: A0A2R8ZP20
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100969400
gene id: 9597:LOC100969400
uniprot id: A0A2R8ZG71
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9597:DNAJC24
gene id: 9597:DNAJC24
uniprot id: A0A2R9ANH5
names: Similarity
messages: Belongs to the DPH4 family.

9597:NPNT
gene id: 9597:NPNT
uniprot id: A0A2R9AYJ2
uniprot id: A0A2R9AZC1
uniprot id: A0A2R9B4L9
uniprot id: A0A2R9B4M3
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PLK4
gene id: 9597:PLK4
uniprot id: A0A2R9AC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9597:DDX47
gene id: 9597:DDX47
uniprot id: A0A2R9C5R5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9597:HOXD10
gene id: 9597:HOXD10
uniprot id: A0A2R9B8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9597:GNAI2
gene id: 9597:GNAI2
uniprot id: A0A2R9ANZ4
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:ALAS2
gene id: 9597:ALAS2
uniprot id: A0A2R8ZRC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9597:PGLYRP1
gene id: 9597:PGLYRP1
uniprot id: A0A2R9BV11
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9597:ATG4A
gene id: 9597:ATG4A
uniprot id: A0A2R8ZNT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9597:CAPN10
gene id: 9597:CAPN10
uniprot id: A0A2R9AF24
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:LDLRAD2
gene id: 9597:LDLRAD2
uniprot id: A0A2R9CMD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SOAT1
gene id: 9597:SOAT1
uniprot id: A0A2R9BQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:HTRA4
gene id: 9597:HTRA4
uniprot id: A0A2R9ATF4
names: Similarity
messages: Belongs to the peptidase S1C family.

9597:CCDC130
gene id: 9597:CCDC130
uniprot id: A0A2R9A3W3
names: Similarity
messages: Belongs to the CWC16 family.

9597:TASOR2
gene id: 9597:TASOR2
uniprot id: A0A2R9A7W7
names: Similarity
messages: Belongs to the TASOR family.

9597:GIMAP1
gene id: 9597:GIMAP1
uniprot id: A0A2R9C9Q1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:RGS3
gene id: 9597:RGS3
uniprot id: A0A2R9AX77
uniprot id: A0A2R9AX90
names: Subcellular Location Annotation
messages: Cytoplasm

9597:TMA16
gene id: 9597:TMA16
uniprot id: A0A2R8Z9K2
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9597:ZER1
gene id: 9597:ZER1
uniprot id: A0A2R9B106
names: Similarity
messages: Belongs to the zyg-11 family.

9597:TNFAIP6
gene id: 9597:TNFAIP6
uniprot id: A0A2R9ACW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GNAI3
gene id: 9597:GNAI3
uniprot id: A0A2R9BVD2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:MAP4K3
gene id: 9597:MAP4K3
uniprot id: A0A2R9AAI2
uniprot id: A0A2R9AAI7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9597:IQCD
gene id: 9597:IQCD
uniprot id: A0A2R9A4L0
uniprot id: A0A2R9A5T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9597:RIN3
gene id: 9597:RIN3
uniprot id: A0A2R9C3W0
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9597:AMY2A
gene id: 9597:AMY2A
uniprot id: A8HDH0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9597:EIF5A2
gene id: 9597:EIF5A2
uniprot id: A0A2R9BAY0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9597:SNX3
gene id: 9597:SNX3
uniprot id: A0A2R9AMC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9597:ABCC8
gene id: 9597:ABCC8
uniprot id: A0A2R8ZS53
names: Subunit
messages: Interacts with KCNJ11.

9597:ACTL6A
gene id: 9597:ACTL6A
uniprot id: A0A2R9AKF6
names: Similarity
messages: Belongs to the actin family.

9597:FOXM1
gene id: 9597:FOXM1
uniprot id: A0A2R9CHJ6
uniprot id: A0A2R9CKA6
names: Subcellular Location Annotation
messages: Nucleus

9597:ZNF446
gene id: 9597:ZNF446
uniprot id: A0A2R9BSW2
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:TRMT13
gene id: 9597:TRMT13
uniprot id: A0A2R9CSI6
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9597:MAOA
gene id: 9597:MAOA
uniprot id: A0A2R9ARD5
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9597:CFAP36
gene id: 9597:CFAP36
uniprot id: A0A2R9BY09
names: Similarity
messages: Belongs to the CFAP36 family.

9597:AGPAT1
gene id: 9597:AGPAT1
uniprot id: A0A2R9BTZ0
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9597:CASTOR1
gene id: 9597:CASTOR1
uniprot id: A0A2R9AUD1
uniprot id: A0A2R9AUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9597:DLC1
gene id: 9597:DLC1
uniprot id: A0A2R9BQ18
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

9597:TAS1R1
gene id: 9597:TAS1R1
uniprot id: A0A2R9AFU2
uniprot id: A0A2R9AGS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:ZNF285
gene id: 9597:ZNF285
uniprot id: A0A2R9APL1
names: Function
messages: May be involved in transcriptional regulation.

9597:LPIN1
gene id: 9597:LPIN1
uniprot id: A0A2R9ARS1
names: Similarity
messages: Belongs to the lipin family.

9597:LOC100974973
gene id: 9597:LOC100974973
uniprot id: A0A2R9AQS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:HPCAL4
gene id: 9597:HPCAL4
uniprot id: A0A2R9AB94
uniprot id: A0A2R9AGU7
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9597:RGN
gene id: 9597:RGN
uniprot id: A0A2R9B6Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

9597:TSHB
gene id: 9597:TSHB
uniprot id: A0A2R9AHW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:ASPM
gene id: 9597:ASPM
uniprot id: A0A2R9CCV8
uniprot id: A0A2R9CFH3
names: Subcellular Location Annotation
messages: Nucleus
messages: spindle

9597:KCNE5
gene id: 9597:KCNE5
uniprot id: A0A2R8ZNK6
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9597:ARSB
gene id: 9597:ARSB
uniprot id: A0A2R9C0H9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:INSL5
gene id: 9597:INSL5
uniprot id: A0A2R8ZN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9597:AGL
gene id: 9597:AGL
uniprot id: A0A2R9BB14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9597:ITIH1
gene id: 9597:ITIH1
uniprot id: A0A2R9C9J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:MRPL19
gene id: 9597:MRPL19
uniprot id: A0A2R9C8M3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9597:LOC100995944
gene id: 9597:LOC100995944
uniprot id: A0A2R9B4Y5
names: Similarity
messages: Belongs to the TACO1 family.

9597:TMEM50A
gene id: 9597:TMEM50A
uniprot id: A0A2R8Z9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9597:SHOX
gene id: 9597:SHOX
uniprot id: A0A2R9B0S0
names: Subcellular Location Annotation
messages: Nucleus

9597:HMGCR
gene id: 9597:HMGCR
uniprot id: A0A2R9B572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9597:NTRK3
gene id: 9597:NTRK3
uniprot id: A0A2R9CFI2
uniprot id: A0A2R9CFJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9597:CCNA2
gene id: 9597:CCNA2
uniprot id: A0A2R9BV77
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9597:SNRNP200
gene id: 9597:SNRNP200
uniprot id: A0A2R9C7E7
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9597:HINT2
gene id: 9597:HINT2
uniprot id: A0A2R8ZB15
names: Similarity
messages: Belongs to the HINT family.

9597:MX1
gene id: 9597:MX1
uniprot id: A0A2R9AZN7
uniprot id: K4JEZ2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9597:FMNL2
gene id: 9597:FMNL2
uniprot id: A0A2R9BRD6
names: Similarity
messages: Belongs to the formin homology family.

9597:DLX3
gene id: 9597:DLX3
uniprot id: A0A2R8Z7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9597:PELP1
gene id: 9597:PELP1
uniprot id: A0A2R9BTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

9597:PAQR4
gene id: 9597:PAQR4
uniprot id: A0A2R9A4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:PTPN21
gene id: 9597:PTPN21
uniprot id: A0A2R9B463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9597:LOC100992975
gene id: 9597:LOC100992975
uniprot id: A0A2R8ZI20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RHBDL2
gene id: 9597:RHBDL2
uniprot id: A0A2R9C7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9597:RAD9B
gene id: 9597:RAD9B
uniprot id: A0A2R8Z9Z3
names: Similarity
messages: Belongs to the rad9 family.

9597:SHBG
gene id: 9597:SHBG
uniprot id: A0A2R9C134
uniprot id: A0A2R9C153
uniprot id: A0A2R9C163
uniprot id: A0A2R9C1N4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RPL12
gene id: 9597:RPL12
uniprot id: A0A2R9ACW1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9597:AMZ2
gene id: 9597:AMZ2
uniprot id: A0A2R9AVH1
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9597:PON3
gene id: 9597:PON3
uniprot id: A0A2R9AP95
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9597:NOTCH2
gene id: 9597:NOTCH2
uniprot id: A0A2R9AAN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9597:D2HGDH
gene id: 9597:D2HGDH
uniprot id: A0A2R8Z5Z2
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9597:U2AF2
gene id: 9597:U2AF2
uniprot id: A0A2R9BWJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9597:STX1B
gene id: 9597:STX1B
uniprot id: A0A2R9C7T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9597:ZDHHC12
gene id: 9597:ZDHHC12
uniprot id: A0A2R9BRK9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:NUTF2
gene id: 9597:NUTF2
uniprot id: A0A2R9CNS8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9597:LOC100985433
gene id: 9597:LOC100985433
uniprot id: A0A2R8ZR86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:RAB3GAP1
gene id: 9597:RAB3GAP1
uniprot id: A0A2R9A2X7
uniprot id: A0A2R9A751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9597:CFAP157
gene id: 9597:CFAP157
uniprot id: A0A2R9BUB0
names: Similarity
messages: Belongs to the CFAP157 family.

9597:LTBP1
gene id: 9597:LTBP1
uniprot id: A0A2R9BKQ5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:ADA
gene id: 9597:ADA
uniprot id: A0A2R8ZN08
uniprot id: A0A2R8ZQZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

9597:CDKN3
gene id: 9597:CDKN3
uniprot id: A0A2R9C6I7
uniprot id: A0A2R9CGT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9597:CREB3L2
gene id: 9597:CREB3L2
uniprot id: A0A2R9CGX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:CANX
gene id: 9597:CANX
uniprot id: A0A2R9AWV7
names: Similarity
messages: Belongs to the calreticulin family.

9597:SLC6A1
gene id: 9597:SLC6A1
uniprot id: A0A2R9CH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:TIMM8A
gene id: 9597:TIMM8A
uniprot id: A0A2R8ZRL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:MANBAL
gene id: 9597:MANBAL
uniprot id: A0A2R9C298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9597:FKTN
gene id: 9597:FKTN
uniprot id: A0A2R8ZUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9597:NSMCE2
gene id: 9597:NSMCE2
uniprot id: A0A2R9CF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9597:ACTN4
gene id: 9597:ACTN4
uniprot id: A0A2R9CB79
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:SPACA3
gene id: 9597:SPACA3
uniprot id: A0A2R9BWV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

9597:NRG1
gene id: 9597:NRG1
uniprot id: A0A2R9A6B4
uniprot id: A0A2R9A6C2
uniprot id: A0A2R9AB27
uniprot id: A0A2R9ABM0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9597:SYCE1L
gene id: 9597:SYCE1L
uniprot id: A0A2R9C0V3
names: Similarity
messages: Belongs to the SYCE family.

9597:ACAD10
gene id: 9597:ACAD10
uniprot id: A0A2R9A8E3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:MPV17
gene id: 9597:MPV17
uniprot id: A0A2R9AZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9597:CALCB
gene id: 9597:CALCB
uniprot id: A0A2R9BXK8
names: Similarity
messages: Belongs to the calcitonin family.

9597:Papa-A
gene id: 9597:Papa-A
uniprot id: Q30900
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

9597:FAM228A
gene id: 9597:FAM228A
uniprot id: A0A2R8ZPQ8
names: Similarity
messages: Belongs to the FAM228 family.

9597:SEH1L
gene id: 9597:SEH1L
uniprot id: A0A2R8ZD69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9597:DLGAP5
gene id: 9597:DLGAP5
uniprot id: A0A2R8ZXB4
uniprot id: A0A2R8ZZL9
names: Similarity
messages: Belongs to the SAPAP family.

9597:PSEN2
gene id: 9597:PSEN2
uniprot id: A0A2R9AA90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9597:EEF1D
gene id: 9597:EEF1D
uniprot id: A0A2R8ZI37
uniprot id: A0A2R8ZI39
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9597:SMAD7
gene id: 9597:SMAD7
uniprot id: A0A2R9AGA7
names: Subcellular Location Annotation
messages: Nucleus

9597:TAS2R16
gene id: 9597:TAS2R16
uniprot id: Q646D1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Cell membrane
messages: Interacts with RTP3 and RTP4.
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:MAPT
gene id: 9597:MAPT
uniprot id: A0A2R8Z985
uniprot id: A0A2R8Z9J4
uniprot id: A0A2R8ZFY4
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

9597:NTNG1
gene id: 9597:NTNG1
uniprot id: A0A2R9CK20
uniprot id: A0A2R9CMN7
uniprot id: A0A2R9CSI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100978828
gene id: 9597:LOC100978828
uniprot id: A0A2R9C8Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9597:RDH12
gene id: 9597:RDH12
uniprot id: A0A2R9C7Y4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:CALR
gene id: 9597:CALR
uniprot id: A0A2R8Z933
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

9597:PIWIL2
gene id: 9597:PIWIL2
uniprot id: W0HFS1
names: Similarity
messages: Belongs to the argonaute family.

9597:SKA3
gene id: 9597:SKA3
uniprot id: A0A2R9BI31
uniprot id: A0A2R9BIY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9597:ZFPL1
gene id: 9597:ZFPL1
uniprot id: A0A2R8ZI90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9597:ANXA5
gene id: 9597:ANXA5
uniprot id: A0A2R9AHE1
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9597:TMEM8B
gene id: 9597:TMEM8B
uniprot id: A0A2R8ZSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9597:CDC42BPA
gene id: 9597:CDC42BPA
uniprot id: A0A2R9AEW0
uniprot id: A0A2R9AEW7
uniprot id: A0A2R9AEX3
uniprot id: A0A2R9AFX2
uniprot id: A0A2R9AJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9597:BMP3
gene id: 9597:BMP3
uniprot id: A0A2R9C6X0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9597:GBE1
gene id: 9597:GBE1
uniprot id: A0A2R9CB94
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9597:PPP1R14D
gene id: 9597:PPP1R14D
uniprot id: A0A2R9BAR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9597:AP1M2
gene id: 9597:AP1M2
uniprot id: A0A2R9CDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9597:CTNNBL1
gene id: 9597:CTNNBL1
uniprot id: A0A2R8ZG40
names: Subcellular Location Annotation
messages: Nucleus

9597:TPM2
gene id: 9597:TPM2
uniprot id: A0A2R9AEL6
uniprot id: A0A2R9AEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:ATAD2B
gene id: 9597:ATAD2B
uniprot id: A0A2R9AS78
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:LOC103783188
gene id: 9597:LOC103783188
uniprot id: A0A2R9B5H8
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:SUDS3
gene id: 9597:SUDS3
uniprot id: A0A2R9BME3
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC28A1
gene id: 9597:SLC28A1
uniprot id: A0A2R9BNC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9597:LHFPL1
gene id: 9597:LHFPL1
uniprot id: A0A2R9B1N4
names: Subcellular Location Annotation
messages: Membrane

9597:SLC10A2
gene id: 9597:SLC10A2
uniprot id: A0A2R8ZLX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9597:GALNT3
gene id: 9597:GALNT3
uniprot id: A0A2R9BCK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:USP37
gene id: 9597:USP37
uniprot id: A0A2R9A530
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:AK1
gene id: 9597:AK1
uniprot id: A0A2R9AYN7
uniprot id: A0A2R9AYP4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9597:HSD17B2
gene id: 9597:HSD17B2
uniprot id: A0A2R9BJN5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:S100A4
gene id: 9597:S100A4
uniprot id: A0A2R8ZE71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:ELK1
gene id: 9597:ELK1
uniprot id: A0A2R9CFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:ABCC9
gene id: 9597:ABCC9
uniprot id: A0A2R9AZ23
uniprot id: A0A2R9AZ28
names: Subunit
messages: Interacts with KCNJ11.

9597:CYLD
gene id: 9597:CYLD
uniprot id: A0A2R9A2C5
uniprot id: A0A2R9A2D3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9597:FOXR2
gene id: 9597:FOXR2
uniprot id: A0A2R8ZLN4
names: Subcellular Location Annotation
messages: Nucleus

9597:TNPO1
gene id: 9597:TNPO1
uniprot id: A0A2R9CNL4
names: Subcellular Location Annotation
messages: Cytoplasm

9597:INTS12
gene id: 9597:INTS12
uniprot id: A0A2R9C2D4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9597:CAPN5
gene id: 9597:CAPN5
uniprot id: A0A2R9AXC4
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:DDX49
gene id: 9597:DDX49
uniprot id: A0A2R9BAA4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:LCA5
gene id: 9597:LCA5
uniprot id: A0A2R8ZKA0
names: Similarity
messages: Belongs to the LCA5 family.

9597:DCK
gene id: 9597:DCK
uniprot id: A0A2R9BA40
names: Similarity
messages: Belongs to the DCK/DGK family.

9597:RAB3C
gene id: 9597:RAB3C
uniprot id: A0A2R8ZB83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9597:GDF9
gene id: 9597:GDF9
uniprot id: A0A2R9B978
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9597:RAMP3
gene id: 9597:RAMP3
uniprot id: A0A2R9C7D1
names: Similarity
messages: Belongs to the RAMP family.

9597:LOC100970092
gene id: 9597:LOC100970092
uniprot id: A0A2R8ZGR6
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9597:ABHD16A
gene id: 9597:ABHD16A
uniprot id: A0A2R9C7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9597:SPPL2A
gene id: 9597:SPPL2A
uniprot id: A0A2R9A3S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9597:KCND1
gene id: 9597:KCND1
uniprot id: A0A2R9B401
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9597:LOC100968913
gene id: 9597:LOC100968913
uniprot id: A0A2R9AKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9597:CNTNAP1
gene id: 9597:CNTNAP1
uniprot id: A0A2R9A9Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9597:CDH7
gene id: 9597:CDH7
uniprot id: A0A2R9C879
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:MS4A4A
gene id: 9597:MS4A4A
uniprot id: A0A2R9A3J7
uniprot id: A0A2R9A7T1
names: Similarity
messages: Belongs to the MS4A family.

9597:NOX5
gene id: 9597:NOX5
uniprot id: A0A2R9BPS1
names: Subcellular Location Annotation
messages: Membrane

9597:LOXL3
gene id: 9597:LOXL3
uniprot id: A0A2R8ZPE4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:COPS4
gene id: 9597:COPS4
uniprot id: A0A2R8ZN25
uniprot id: A0A2R8ZP91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9597:MYORG
gene id: 9597:MYORG
uniprot id: A0A2R8ZJA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9597:HAAO
gene id: 9597:HAAO
uniprot id: A0A2R8Z9N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9597:CD8B
gene id: 9597:CD8B
uniprot id: A0A2R9C6U7
names: Subcellular Location Annotation
messages: Membrane

9597:NMBR
gene id: 9597:NMBR
uniprot id: A0A2R9CMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:CYP19A1
gene id: 9597:CYP19A1
uniprot id: A0A2R9A604
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:LOC100989580
gene id: 9597:LOC100989580
uniprot id: A0A2R8ZNF4
names: Subunit
messages: Interacts with hair keratins.

9597:CSTA
gene id: 9597:CSTA
uniprot id: A0A2R9CEC6
names: Similarity
messages: Belongs to the cystatin family.

9597:TCHP
gene id: 9597:TCHP
uniprot id: A0A2R9BN22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCHP family.
messages: cytoskeleton

9597:MPPED2
gene id: 9597:MPPED2
uniprot id: A0A2R8ZLC2
names: Similarity
messages: Belongs to the UPF0046 family.

9597:SLC13A1
gene id: 9597:SLC13A1
uniprot id: A0A2R9BYP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9597:HTR1F
gene id: 9597:HTR1F
uniprot id: A0A2R8ZDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9597:AOC2
gene id: 9597:AOC2
uniprot id: A0A2R9CKS0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9597:AGPAT4
gene id: 9597:AGPAT4
uniprot id: A0A2R9CBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:KHDRBS1
gene id: 9597:KHDRBS1
uniprot id: A0A2R9B8Q7
names: Similarity
messages: Belongs to the KHDRBS family.

9597:FERMT2
gene id: 9597:FERMT2
uniprot id: A0A2R9B007
uniprot id: A0A2R9B1Z3
names: Similarity
messages: Belongs to the kindlin family.

9597:TOB1
gene id: 9597:TOB1
uniprot id: A0A2R8ZD48
names: Similarity
messages: Belongs to the BTG family.

9597:CYRIB
gene id: 9597:CYRIB
uniprot id: A0A2R9CCT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9597:PPFIBP1
gene id: 9597:PPFIBP1
uniprot id: A0A2R9B1G1
uniprot id: A0A2R9B1G5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9597:LOC100971425
gene id: 9597:LOC100971425
uniprot id: A0A2R9C648
uniprot id: A0A2R9C8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9597:GREM2
gene id: 9597:GREM2
uniprot id: A0A2R8ZBR1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:TBX18
gene id: 9597:TBX18
uniprot id: A0A2R9A1N2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:ZNF75D
gene id: 9597:ZNF75D
uniprot id: A0A2R9BDD6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:TEF
gene id: 9597:TEF
uniprot id: A0A2R9B9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9597:TLR7
gene id: 9597:TLR7
uniprot id: B3Y649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:SRSF2
gene id: 9597:SRSF2
uniprot id: A0A2R9ALQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

9597:CENPL
gene id: 9597:CENPL
uniprot id: A0A2R8ZFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9597:CYP2G2
gene id: 9597:CYP2G2
uniprot id: A0A2R9C0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:GNPDA1
gene id: 9597:GNPDA1
uniprot id: A0A2R9BM46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9597:CPXM2
gene id: 9597:CPXM2
uniprot id: A0A2R9BN00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9597:CCN4
gene id: 9597:CCN4
uniprot id: A0A2R9CCT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:LOC100982788
gene id: 9597:LOC100982788
uniprot id: A0A2R9AE21
names: Similarity
messages: Belongs to the PRAME family.

9597:IKBKB
gene id: 9597:IKBKB
uniprot id: A0A2R9AXR5
uniprot id: A0A2R9AXT3
uniprot id: A0A2R9B3R9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:PADI3
gene id: 9597:PADI3
uniprot id: A0A2R9CL57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9597:MAP2K6
gene id: 9597:MAP2K6
uniprot id: A0A2R9BGH1
uniprot id: A0A2R9BHG8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:GATA3
gene id: 9597:GATA3
uniprot id: A0A2R8ZRJ9
names: Subcellular Location Annotation
messages: Nucleus

9597:ZNF620
gene id: 9597:ZNF620
uniprot id: A0A2R9C4H0
names: Function
messages: May be involved in transcriptional regulation.

9597:PPP1R9A
gene id: 9597:PPP1R9A
uniprot id: A0A2R9CGB8
uniprot id: A0A2R9CGD3
names: Subcellular Location Annotation
messages: cytoskeleton

9597:NUDT7
gene id: 9597:NUDT7
uniprot id: A0A2R9BVP5
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9597:RNASEK
gene id: 9597:RNASEK
uniprot id: A0A2R9BX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

9597:HLX
gene id: 9597:HLX
uniprot id: A0A2R9APK8
names: Subcellular Location Annotation
messages: Nucleus

9597:MPHOSPH10
gene id: 9597:MPHOSPH10
uniprot id: A0A2R9ARM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9597:FAM126B
gene id: 9597:FAM126B
uniprot id: A0A2R9C234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9597:B3GNT2
gene id: 9597:B3GNT2
uniprot id: A0A2R8ZMJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:NPR3
gene id: 9597:NPR3
uniprot id: A0A2R9AEI1
uniprot id: A0A2R9AL31
names: Subcellular Location Annotation
messages: Membrane

9597:CRY1
gene id: 9597:CRY1
uniprot id: A0A2R8ZDU0
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9597:DIO1
gene id: 9597:DIO1
uniprot id: A0A2R9CBB7
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9597:AGXT2
gene id: 9597:AGXT2
uniprot id: A0A2R9B5M5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:LOC100985787
gene id: 9597:LOC100985787
uniprot id: A0A2R8ZE56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ZNF878
gene id: 9597:ZNF878
uniprot id: A0A2R9AE49
names: Function
messages: May be involved in transcriptional regulation.

9597:PIK3CG
gene id: 9597:PIK3CG
uniprot id: A0A2R9CFV4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:FLNB
gene id: 9597:FLNB
uniprot id: A0A2R9ADY8
uniprot id: A0A2R9AJ93
names: Similarity
messages: Belongs to the filamin family.

9597:YWHAZ
gene id: 9597:YWHAZ
uniprot id: A0A2R9BQD0
names: Similarity
messages: Belongs to the 14-3-3 family.

9597:IYD
gene id: 9597:IYD
uniprot id: A0A2R9B3G8
uniprot id: A0A2R9B3H2
uniprot id: A0A2R9B3I3
uniprot id: A0A2R9B550
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane

9597:KRT32
gene id: 9597:KRT32
uniprot id: A0A2R8ZEN7
names: Similarity
messages: Belongs to the intermediate filament family.

9597:KRT18
gene id: 9597:KRT18
uniprot id: A0A2R9CIV2
names: Similarity
messages: Belongs to the intermediate filament family.

9597:OTULINL
gene id: 9597:OTULINL
uniprot id: A0A2R8ZJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9597:LOC100974724
gene id: 9597:LOC100974724
uniprot id: A0A2R8ZBM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ATP11C
gene id: 9597:ATP11C
uniprot id: A0A2R9CIT9
uniprot id: A0A2R9CLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:KDM4B
gene id: 9597:KDM4B
uniprot id: A0A2R9B952
uniprot id: A0A2R9BCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9597:LOC100974357
gene id: 9597:LOC100974357
uniprot id: A0A2R8ZII4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:METTL14
gene id: 9597:METTL14
uniprot id: A0A2R9A9D6
names: Similarity
messages: Belongs to the MT-A70-like family.

9597:CDC42EP2
gene id: 9597:CDC42EP2
uniprot id: A0A2R8ZHL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9597:CCDC103
gene id: 9597:CCDC103
uniprot id: A0A2R8ZE44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9597:MAP1LC3B
gene id: 9597:MAP1LC3B
uniprot id: A0A2R9AC06
names: Similarity
messages: Belongs to the ATG8 family.

9597:GHRHR
gene id: 9597:GHRHR
uniprot id: A0A2R9AAT3
names: Subcellular Location Annotation
messages: Membrane

9597:SLC5A8
gene id: 9597:SLC5A8
uniprot id: A0A2R9BLW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9597:PELI1
gene id: 9597:PELI1
uniprot id: A0A2R9CTL4
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9597:OLFM4
gene id: 9597:OLFM4
uniprot id: A0A2R9BC21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:USP44
gene id: 9597:USP44
uniprot id: A0A2R9AI97
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:ITGB1
gene id: 9597:ITGB1
uniprot id: A0A2R9BQG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9597:DNAJB12
gene id: 9597:DNAJB12
uniprot id: A0A2R9BHL0
names: Subcellular Location Annotation
messages: Membrane

9597:VWF
gene id: 9597:VWF
uniprot id: A0A2R8ZVE3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9597:LOC100972936
gene id: 9597:LOC100972936
uniprot id: A0A2R8ZE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:STK4
gene id: 9597:STK4
uniprot id: A0A2R8ZVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9597:PANX1
gene id: 9597:PANX1
uniprot id: A0A2R9C7D5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9597:TMEM91
gene id: 9597:TMEM91
uniprot id: A0A2R9BNY8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:PGS1
gene id: 9597:PGS1
uniprot id: A0A2R9AEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9597:DEFB124
gene id: 9597:DEFB124
uniprot id: A0A2R9AAG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:EFNB2
gene id: 9597:EFNB2
uniprot id: A0A2R9A2R0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TUBD1
gene id: 9597:TUBD1
uniprot id: A0A2R9AIX3
uniprot id: A0A2R9AIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9597:AMDHD2
gene id: 9597:AMDHD2
uniprot id: A0A2R9AV22
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

9597:FGR
gene id: 9597:FGR
uniprot id: A0A2R9A4Q1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:LOC100976465
gene id: 9597:LOC100976465
uniprot id: P68872
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA).
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9597:CMAH
gene id: 9597:CMAH
uniprot id: A0A2R9B733
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9597:ACER3
gene id: 9597:ACER3
uniprot id: A0A2R8ZFR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9597:RANBP10
gene id: 9597:RANBP10
uniprot id: A0A2R9BMZ7
names: Similarity
messages: Belongs to the RANBP9/10 family.

9597:RAMP1
gene id: 9597:RAMP1
uniprot id: A0A2R9B9U4
names: Similarity
messages: Belongs to the RAMP family.

9597:GPR12
gene id: 9597:GPR12
uniprot id: A0A2R8ZDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:PARPBP
gene id: 9597:PARPBP
uniprot id: A0A2R9BME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9597:GALNT13
gene id: 9597:GALNT13
uniprot id: A0A2R9B4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:LASP1
gene id: 9597:LASP1
uniprot id: A0A2R8Z9S7
uniprot id: A0A2R8ZG60
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9597:VSIG1
gene id: 9597:VSIG1
uniprot id: A0A2R9B5R4
uniprot id: A0A2R9B5S2
names: Subcellular Location Annotation
messages: Membrane

9597:CHRNG
gene id: 9597:CHRNG
uniprot id: A0A2R9CIL1
uniprot id: A0A2R9CRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:TRAPPC2B
gene id: 9597:TRAPPC2B
uniprot id: A0A2R9BQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9597:SERPINB12
gene id: 9597:SERPINB12
uniprot id: A0A2R8ZU00
names: Similarity
messages: Belongs to the serpin family.

9597:RPF1
gene id: 9597:RPF1
uniprot id: A0A2R9BSD1
names: Subcellular Location Annotation
messages: nucleolus

9597:MCM2
gene id: 9597:MCM2
uniprot id: A0A2R8ZAB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9597:RAB38
gene id: 9597:RAB38
uniprot id: A0A2R9BF11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9597:TMEM120A
gene id: 9597:TMEM120A
uniprot id: A0A2R9B2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9597:CFAP97
gene id: 9597:CFAP97
uniprot id: A0A2R9A6H5
uniprot id: A0A2R9A6I1
names: Similarity
messages: Belongs to the CFAP97 family.

9597:LOC100971962
gene id: 9597:LOC100971962
uniprot id: A0A2R8Z8X2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SLC39A1
gene id: 9597:SLC39A1
uniprot id: A0A2R9CDA8
names: Subcellular Location Annotation
messages: Membrane

9597:ABCD3
gene id: 9597:ABCD3
uniprot id: A0A2R9BW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9597:NAT1
gene id: 9597:NAT1
uniprot id: A0A4P8J1D3
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9597:CRYBG3
gene id: 9597:CRYBG3
uniprot id: A0A2R9BY08
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:BUD31
gene id: 9597:BUD31
uniprot id: A0A2R9C277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9597:OTC
gene id: 9597:OTC
uniprot id: A0A2R9AD21
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9597:ISL1
gene id: 9597:ISL1
uniprot id: A0A2R9B1B8
names: Subcellular Location Annotation
messages: Nucleus

9597:IK
gene id: 9597:IK
uniprot id: A0A2R8ZGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9597:NPM1
gene id: 9597:NPM1
uniprot id: A0A2R9C8S0
uniprot id: A0A2R9C8S7
names: Similarity
messages: Belongs to the nucleoplasmin family.

9597:LONP2
gene id: 9597:LONP2
uniprot id: A0A2R9AV09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9597:MUS81
gene id: 9597:MUS81
uniprot id: A0A2R8ZM69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9597:TUBGCP3
gene id: 9597:TUBGCP3
uniprot id: A0A2R8ZBL3
uniprot id: A0A2R8ZID3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9597:CCNB2
gene id: 9597:CCNB2
uniprot id: A0A2R9BSA0
names: Similarity
messages: Belongs to the cyclin family.

9597:RPL22L1
gene id: 9597:RPL22L1
uniprot id: A0A2R9B3J2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9597:SLC35E3
gene id: 9597:SLC35E3
uniprot id: A0A2R9BVJ4
names: Subcellular Location Annotation
messages: Membrane

9597:RXRB
gene id: 9597:RXRB
uniprot id: A0A2R9BXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9597:ZNF875
gene id: 9597:ZNF875
uniprot id: A0A2R9A6J8
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100971948
gene id: 9597:LOC100971948
uniprot id: A0A2R9ALK8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9597:PTP4A2
gene id: 9597:PTP4A2
uniprot id: A0A2R9AQP1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9597:PDE4D
gene id: 9597:PDE4D
uniprot id: A0A2R9CIU9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:SYNDIG1L
gene id: 9597:SYNDIG1L
uniprot id: A0A2R9BLP2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:PHC2
gene id: 9597:PHC2
uniprot id: A0A2R8ZL28
uniprot id: A0A2R8ZL33
uniprot id: A0A2R8ZNX1
names: Subcellular Location Annotation
messages: Nucleus

9597:CWF19L2
gene id: 9597:CWF19L2
uniprot id: A0A2R8ZSA2
names: Similarity
messages: Belongs to the CWF19 family.

9597:GTF2A2
gene id: 9597:GTF2A2
uniprot id: A0A2R9BP38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9597:HOGA1
gene id: 9597:HOGA1
uniprot id: A0A2R8ZPI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9597:KANSL2
gene id: 9597:KANSL2
uniprot id: A0A2R8ZR03
uniprot id: A0A2R8ZWU0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9597:EFNB1
gene id: 9597:EFNB1
uniprot id: A0A2R9C3A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:DEF8
gene id: 9597:DEF8
uniprot id: A0A2R9A7H0
names: Similarity
messages: Belongs to the DEF8 family.

9597:INHBA
gene id: 9597:INHBA
uniprot id: A0A2R9BD91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9597:LOC100995311
gene id: 9597:LOC100995311
uniprot id: A0A2R9AQE6
names: Subcellular Location Annotation
messages: Membrane

9597:GPR68
gene id: 9597:GPR68
uniprot id: A0A2R8Z941
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:PLA2G12A
gene id: 9597:PLA2G12A
uniprot id: A0A2R9A9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9597:C5H5orf22
gene id: 9597:C5H5orf22
uniprot id: A0A2R9A9A3
names: Similarity
messages: Belongs to the UPF0489 family.

9597:STRA6
gene id: 9597:STRA6
uniprot id: A0A2R9B7F3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:NCBP1
gene id: 9597:NCBP1
uniprot id: A0A2R8ZS19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9597:SYNE4
gene id: 9597:SYNE4
uniprot id: A0A2R9AW54
uniprot id: A0A2R9AZY2
names: Similarity
messages: Belongs to the nesprin family.

9597:ZSCAN21
gene id: 9597:ZSCAN21
uniprot id: A0A2R8ZS42
uniprot id: A1YG26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity).

9597:LOC103783322
gene id: 9597:LOC103783322
uniprot id: P60181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:CDK15
gene id: 9597:CDK15
uniprot id: A0A2R8ZWU4
uniprot id: A0A2R8ZWU8
uniprot id: A0A2R8ZZ90
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:EPYC
gene id: 9597:EPYC
uniprot id: A0A2R9A7S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

9597:LOC100973895
gene id: 9597:LOC100973895
uniprot id: A0A2R8ZFI4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:UNG
gene id: 9597:UNG
uniprot id: A0A2R8ZKC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

9597:FXR1
gene id: 9597:FXR1
uniprot id: A0A2R9BTK0
names: Similarity
messages: Belongs to the FMR1 family.

9597:PARD6A
gene id: 9597:PARD6A
uniprot id: A0A2R9BT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9597:LOC100992900
gene id: 9597:LOC100992900
uniprot id: A0A2R8ZP79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:LOC103787041
gene id: 9597:LOC103787041
uniprot id: A0A2R9BL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9597:CSNK1A1
gene id: 9597:CSNK1A1
uniprot id: A0A2R9C4S3
uniprot id: A0A2R9CFB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TLR2
gene id: 9597:TLR2
uniprot id: B3Y614
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9597:PLA2G4F
gene id: 9597:PLA2G4F
uniprot id: A0A2R9AYX5
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9597:ZNF684
gene id: 9597:ZNF684
uniprot id: A0A2R9AEE5
names: Function
messages: May be involved in transcriptional regulation.

9597:PHACTR2
gene id: 9597:PHACTR2
uniprot id: A0A2R9C152
uniprot id: A0A2R9C3N9
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9597:AP1G2
gene id: 9597:AP1G2
uniprot id: A0A2R9AE73
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:CAPN11
gene id: 9597:CAPN11
uniprot id: A0A2R9BB88
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:MANEA
gene id: 9597:MANEA
uniprot id: A0A2R9CIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:CLDN25
gene id: 9597:CLDN25
uniprot id: A0A2R8Z9P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:C1H1orf174
gene id: 9597:C1H1orf174
uniprot id: A0A2R9AGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9597:EFHC2
gene id: 9597:EFHC2
uniprot id: A0A2R9BHX8
names: Subcellular Location Annotation
messages: cilium axoneme

9597:DOK3
gene id: 9597:DOK3
uniprot id: A0A2R9AEB1
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9597:TXNL4A
gene id: 9597:TXNL4A
uniprot id: A0A2R9B0Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9597:TAF8
gene id: 9597:TAF8
uniprot id: A0A2R8Z7P7
uniprot id: A0A2R8Z7Q1
uniprot id: A0A2R8Z7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9597:PLN
gene id: 9597:PLN
uniprot id: A0A2R8ZJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9597:SSBP2
gene id: 9597:SSBP2
uniprot id: A0A2R9AHG7
uniprot id: A0A2R9AIM6
names: Subcellular Location Annotation
messages: Nucleus

9597:CLNS1A
gene id: 9597:CLNS1A
uniprot id: A0A2R9B7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9597:FMO5
gene id: 9597:FMO5
uniprot id: A0A2R9AK06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:HEATR5B
gene id: 9597:HEATR5B
uniprot id: A0A2R9C824
names: Similarity
messages: Belongs to the HEATR5 family.

9597:MCM8
gene id: 9597:MCM8
uniprot id: A0A2R9AVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9597:GJD2
gene id: 9597:GJD2
uniprot id: A0A2R8ZQX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:PDCL
gene id: 9597:PDCL
uniprot id: A0A2R8ZQ76
names: Similarity
messages: Belongs to the phosducin family.

9597:MRPL13
gene id: 9597:MRPL13
uniprot id: A0A2R9CJ45
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9597:SF3B4
gene id: 9597:SF3B4
uniprot id: A0A2R9C2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9597:TM7SF3
gene id: 9597:TM7SF3
uniprot id: A0A2R9AXP7
names: Subcellular Location Annotation
messages: Membrane

9597:PARP1
gene id: 9597:PARP1
uniprot id: A0A2R9C5K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9597:GOSR2
gene id: 9597:GOSR2
uniprot id: A0A2R8ZEQ6
uniprot id: A0A2R8ZF05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9597:TMEM86B
gene id: 9597:TMEM86B
uniprot id: A0A2R9A1I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9597:ATP5PD
gene id: 9597:ATP5PD
uniprot id: A0A2R9BBD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9597:SLC35E4
gene id: 9597:SLC35E4
uniprot id: A0A2R9ANN3
names: Subcellular Location Annotation
messages: Membrane

9597:APOLD1
gene id: 9597:APOLD1
uniprot id: A0A2R8ZFP6
uniprot id: A0A2R8ZM40
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:ARHGEF3
gene id: 9597:ARHGEF3
uniprot id: A0A2R9BM68
uniprot id: A0A2R9BMC9
uniprot id: A0A2R9BN46
uniprot id: A0A2R9BQT6
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9597:RAB3IL1
gene id: 9597:RAB3IL1
uniprot id: A0A2R9CC19
names: Similarity
messages: Belongs to the SEC2 family.

9597:ENTPD5
gene id: 9597:ENTPD5
uniprot id: A0A2R9A7Y0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:HIKESHI
gene id: 9597:HIKESHI
uniprot id: A0A2R9BH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9597:UPK1B
gene id: 9597:UPK1B
uniprot id: A0A2R9BNL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9597:CIT
gene id: 9597:CIT
uniprot id: A0A2R9BDB7
uniprot id: A0A2R9BHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9597:ZDHHC3
gene id: 9597:ZDHHC3
uniprot id: A0A2R9AFS3
uniprot id: A0A2R9AGE2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:TMEM186
gene id: 9597:TMEM186
uniprot id: A0A2R9BFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9597:CSTF1
gene id: 9597:CSTF1
uniprot id: A0A2R9BSV4
names: Subcellular Location Annotation
messages: Nucleus

9597:PPM1L
gene id: 9597:PPM1L
uniprot id: A0A2R9CE87
names: Similarity
messages: Belongs to the PP2C family.

9597:LOC100987067
gene id: 9597:LOC100987067
uniprot id: A0A2R9AKJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Odorant receptor.

9597:CHRM1
gene id: 9597:CHRM1
uniprot id: A0A2R8ZHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9597:LOC103783476
gene id: 9597:LOC103783476
uniprot id: A0A2R8ZRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CERS3
gene id: 9597:CERS3
uniprot id: A0A2R8ZE42
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:CXCL10
gene id: 9597:CXCL10
uniprot id: A0A2R9BLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:CXCL14
gene id: 9597:CXCL14
uniprot id: A0A2R9BWC6
names: Subcellular Location Annotation
messages: Secreted

9597:MTRF1
gene id: 9597:MTRF1
uniprot id: A0A2R8Z5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9597:RPS12
gene id: 9597:RPS12
uniprot id: A0A2R9CR19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9597:SLC1A1
gene id: 9597:SLC1A1
uniprot id: A0A2R8ZZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:MICAL1
gene id: 9597:MICAL1
uniprot id: A0A2R9C430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9597:TMEM11
gene id: 9597:TMEM11
uniprot id: A0A2R9CG01
uniprot id: A0A2R9CQB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9597:NR1D1
gene id: 9597:NR1D1
uniprot id: A0A2R9CEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:TMPRSS11E
gene id: 9597:TMPRSS11E
uniprot id: A0A2R9C1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9597:GYS1
gene id: 9597:GYS1
uniprot id: A0A2R9BUZ0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9597:KCNJ1
gene id: 9597:KCNJ1
uniprot id: A0A2R8ZC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:GOLPH3L
gene id: 9597:GOLPH3L
uniprot id: A0A2R8ZGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9597:ANAPC2
gene id: 9597:ANAPC2
uniprot id: A0A2R9CGV8
names: Similarity
messages: Belongs to the cullin family.

9597:ATP5MG
gene id: 9597:ATP5MG
uniprot id: A0A2R8Z8D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9597:LOC100989812
gene id: 9597:LOC100989812
uniprot id: A0A2R8Z9N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:BET1L
gene id: 9597:BET1L
uniprot id: A0A2R8ZEA9
names: Subcellular Location Annotation
messages: Membrane

9597:GSKIP
gene id: 9597:GSKIP
uniprot id: A0A2R9B495
names: Similarity
messages: Belongs to the GSKIP family.

9597:LHX1
gene id: 9597:LHX1
uniprot id: A0A2R9C5I6
names: Subcellular Location Annotation
messages: Nucleus

9597:LAMTOR1
gene id: 9597:LAMTOR1
uniprot id: A0A2R9C3K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9597:MITF
gene id: 9597:MITF
uniprot id: A0A2R9C5E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9597:DDX1
gene id: 9597:DDX1
uniprot id: A0A2R8ZXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

9597:MPP2
gene id: 9597:MPP2
uniprot id: A0A2R9B1M1
uniprot id: A0A2R9B1S9
names: Similarity
messages: Belongs to the MAGUK family.

9597:ARAP2
gene id: 9597:ARAP2
uniprot id: A0A2R9C069
uniprot id: A0A2R9C079
names: Subcellular Location Annotation
messages: Cytoplasm

9597:REXO2
gene id: 9597:REXO2
uniprot id: A0A2R9BWC5
names: Similarity
messages: Belongs to the oligoribonuclease family.

9597:BEST1
gene id: 9597:BEST1
uniprot id: A0A2R9A1Z6
uniprot id: A0A2R9A6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:TMC1
gene id: 9597:TMC1
uniprot id: A0A2R9AMV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:PDE1C
gene id: 9597:PDE1C
uniprot id: A0A2R9CEK6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:MTRNR2L8
gene id: 9597:MTRNR2L8
uniprot id: A0A2R8ZG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9597:KCNT2
gene id: 9597:KCNT2
uniprot id: A0A2R9ASQ1
uniprot id: A0A2R9AX18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:EIF1
gene id: 9597:EIF1
uniprot id: A0A2R9B599
names: Similarity
messages: Belongs to the SUI1 family.

9597:HNF1B
gene id: 9597:HNF1B
uniprot id: A0A2R9C2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9597:RARA
gene id: 9597:RARA
uniprot id: A0A2R9CKZ4
uniprot id: A0A2R9CL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:DEFB110
gene id: 9597:DEFB110
uniprot id: A0A2R9CCY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:SIKE1
gene id: 9597:SIKE1
uniprot id: A0A2R9AKY9
names: Similarity
messages: Belongs to the SIKE family.

9597:TADA2A
gene id: 9597:TADA2A
uniprot id: A0A2R9C7T3
names: Subcellular Location Annotation
messages: Nucleus

9597:TCTEX1D1
gene id: 9597:TCTEX1D1
uniprot id: A0A2R9CKD8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:TMEM205
gene id: 9597:TMEM205
uniprot id: A0A2R9BS18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9597:BCL9
gene id: 9597:BCL9
uniprot id: A0A2R9A031
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9597:NPM3
gene id: 9597:NPM3
uniprot id: A0A2R9C0F3
names: Similarity
messages: Belongs to the nucleoplasmin family.

9597:ERF
gene id: 9597:ERF
uniprot id: A0A2R8ZX10
uniprot id: A0A2R9A2L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:FAN1
gene id: 9597:FAN1
uniprot id: A0A2R9C9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9597:ADAM15
gene id: 9597:ADAM15
uniprot id: A0A2R9BLW5
uniprot id: A0A2R9BLW9
uniprot id: A0A2R9BM08
uniprot id: A0A2R9BMT1
uniprot id: A0A2R9BVZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NIP7
gene id: 9597:NIP7
uniprot id: A0A2R8ZC01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9597:COQ2
gene id: 9597:COQ2
uniprot id: A0A2R9BPT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner.
messages: Mitochondrion inner membrane

9597:SLC35F6
gene id: 9597:SLC35F6
uniprot id: A0A2R8ZNR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9597:ALLC
gene id: 9597:ALLC
uniprot id: A0A2R9CJV7
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9597:FOS
gene id: 9597:FOS
uniprot id: A0A2R8ZK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9597:SLC39A4
gene id: 9597:SLC39A4
uniprot id: A0A2R9BKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9597:ACAD8
gene id: 9597:ACAD8
uniprot id: A0A2R8ZBF2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:MPPE1
gene id: 9597:MPPE1
uniprot id: A0A2R8ZL51
uniprot id: A0A2R8ZL54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9597:PXMP2
gene id: 9597:PXMP2
uniprot id: A0A2R9BSE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9597:PYCR3
gene id: 9597:PYCR3
uniprot id: A0A2R8ZZF5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9597:TSR2
gene id: 9597:TSR2
uniprot id: A0A2R8ZJG2
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9597:NAP1L3
gene id: 9597:NAP1L3
uniprot id: A0A2R8ZPP2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:MMP1
gene id: 9597:MMP1
uniprot id: A0A2R9C2G5
names: Similarity
messages: Belongs to the peptidase M10A family.

9597:CDH11
gene id: 9597:CDH11
uniprot id: A0A2R8ZND1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:EDN3
gene id: 9597:EDN3
uniprot id: A0A2R9B636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9597:BCL7C
gene id: 9597:BCL7C
uniprot id: A0A2R9BQZ2
names: Similarity
messages: Belongs to the BCL7 family.

9597:ADH4
gene id: 9597:ADH4
uniprot id: A0A2R9CDG7
uniprot id: A0A2R9CNV9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

9597:PPM1K
gene id: 9597:PPM1K
uniprot id: A0A2R9CCF4
names: Similarity
messages: Belongs to the PP2C family.

9597:F13B
gene id: 9597:F13B
uniprot id: A0A2R9AQU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ASB14
gene id: 9597:ASB14
uniprot id: A0A2R9C1K6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:CASD1
gene id: 9597:CASD1
uniprot id: A0A2R9C9U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9597:ST3GAL5
gene id: 9597:ST3GAL5
uniprot id: A0A2R9AD61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LOC100991978
gene id: 9597:LOC100991978
uniprot id: A0A2R9C432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9597:TSG101
gene id: 9597:TSG101
uniprot id: A0A2R9AQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

9597:C8B
gene id: 9597:C8B
uniprot id: A0A2R9C373
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:ADGRG7
gene id: 9597:ADGRG7
uniprot id: A0A2R9AGG6
uniprot id: A0A2R9AN92
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100988316
gene id: 9597:LOC100988316
uniprot id: A0A2R9BY24
names: Similarity
messages: Belongs to the LEO1 family.

9597:YPEL4
gene id: 9597:YPEL4
uniprot id: A0A2R9AMH0
names: Similarity
messages: Belongs to the yippee family.

9597:POMT2
gene id: 9597:POMT2
uniprot id: A0A2R9AB99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9597:ZNF485
gene id: 9597:ZNF485
uniprot id: A0A2R8ZR33
names: Function
messages: May be involved in transcriptional regulation.

9597:LPL
gene id: 9597:LPL
uniprot id: A0A2R8ZTC4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9597:MARK3
gene id: 9597:MARK3
uniprot id: A0A2R9AEA1
uniprot id: A0A2R9AJ56
uniprot id: A0A2R9AKV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:LOC100978613
gene id: 9597:LOC100978613
uniprot id: A0A2R8ZCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9597:DDX53
gene id: 9597:DDX53
uniprot id: A0A2R8ZDA1
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:EIF2B2
gene id: 9597:EIF2B2
uniprot id: A0A2R9AGX7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9597:TOMM22
gene id: 9597:TOMM22
uniprot id: A0A2R9AR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9597:DHDH
gene id: 9597:DHDH
uniprot id: A0A2R9BFW6
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:ERGIC2
gene id: 9597:ERGIC2
uniprot id: A0A2R9ABJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9597:PIK3C2B
gene id: 9597:PIK3C2B
uniprot id: A0A2R9AIX4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:PNLDC1
gene id: 9597:PNLDC1
uniprot id: A0A2R8ZR07
names: Similarity
messages: Belongs to the CAF1 family.

9597:FGFR3
gene id: 9597:FGFR3
uniprot id: A0A2R9AXL3
uniprot id: A0A2R9AY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:THNSL2
gene id: 9597:THNSL2
uniprot id: A0A2R9C1Y1
names: Similarity
messages: Belongs to the threonine synthase family.

9597:LOC100984344
gene id: 9597:LOC100984344
uniprot id: A0A2R9AZ99
uniprot id: A0A2R9B0M1
uniprot id: A0A2R9B3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9597:ORC6
gene id: 9597:ORC6
uniprot id: A0A2R9BQP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9597:LOC100968432
gene id: 9597:LOC100968432
uniprot id: A0A2R9A9R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9597:RPN2
gene id: 9597:RPN2
uniprot id: A0A2R9C2J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9597:TMEM14A
gene id: 9597:TMEM14A
uniprot id: A0A2R9B801
names: Similarity
messages: Belongs to the TMEM14 family.

9597:TMEM178B
gene id: 9597:TMEM178B
uniprot id: A0A2R8Z743
names: Similarity
messages: Belongs to the TMEM178 family.

9597:TBP
gene id: 9597:TBP
uniprot id: A0A2R9AGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9597:PGPEP1
gene id: 9597:PGPEP1
uniprot id: A0A2R9ABG4
uniprot id: A0A2R9ABG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9597:DHRS3
gene id: 9597:DHRS3
uniprot id: A0A2R9CHQ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:SPATS2L
gene id: 9597:SPATS2L
uniprot id: A0A2R9BGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9597:LRP6
gene id: 9597:LRP6
uniprot id: A0A2R9B648
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CBR1
gene id: 9597:CBR1
uniprot id: A0A2R9ARG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9597:ENPP2
gene id: 9597:ENPP2
uniprot id: A0A2R9AJU3
uniprot id: A0A2R9AJU7
uniprot id: A0A2R9APG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9597:LOC100981854
gene id: 9597:LOC100981854
uniprot id: A0A2R9BBV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9597:CWC25
gene id: 9597:CWC25
uniprot id: A0A2R8ZL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9597:GTF2H2C
gene id: 9597:GTF2H2C
uniprot id: A0A2R9BCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9597:PIGL
gene id: 9597:PIGL
uniprot id: A0A2R9CBY2
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9597:EZR
gene id: 9597:EZR
uniprot id: A0A2R9BDY7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:LOC100992828
gene id: 9597:LOC100992828
uniprot id: A0A2R8ZCH9
names: Similarity
messages: Belongs to the MIF family.

9597:GDA
gene id: 9597:GDA
uniprot id: A0A2R9BNQ9
uniprot id: A0A2R9BPF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9597:FIS1
gene id: 9597:FIS1
uniprot id: A0A2R9BAE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9597:PFDN5
gene id: 9597:PFDN5
uniprot id: A0A2R9BEU9
uniprot id: A0A2R9BG05
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9597:LOC100980586
gene id: 9597:LOC100980586
uniprot id: A0A2R9CE33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9597:LOC100992114
gene id: 9597:LOC100992114
uniprot id: A0A2R8ZNC5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SLC25A40
gene id: 9597:SLC25A40
uniprot id: A0A2R9CIG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9597:CENPS
gene id: 9597:CENPS
uniprot id: A0A2R9BKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9597:TMOD4
gene id: 9597:TMOD4
uniprot id: A0A2R9ANE4
names: Subcellular Location Annotation
messages: cytoskeleton

9597:SS18
gene id: 9597:SS18
uniprot id: A0A2R9BHB4
uniprot id: A0A2R9BR14
names: Similarity
messages: Belongs to the SS18 family.

9597:SCN9A
gene id: 9597:SCN9A
uniprot id: A0A2R9AXG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9597:NCAPD3
gene id: 9597:NCAPD3
uniprot id: A0A2R9CLG1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9597:GSTO1
gene id: 9597:GSTO1
uniprot id: A0A2R9A5C4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9597:LAMB1
gene id: 9597:LAMB1
uniprot id: A0A2R9A2B3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9597:GORASP2
gene id: 9597:GORASP2
uniprot id: A0A2R9APA5
names: Similarity
messages: Belongs to the GORASP family.

9597:IL12B
gene id: 9597:IL12B
uniprot id: A0A2R9BID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
messages: Secreted

9597:EEF1G
gene id: 9597:EEF1G
uniprot id: A0A2R9CLP5
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9597:BDH1
gene id: 9597:BDH1
uniprot id: A0A2R9AZ51
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:DYNC1LI1
gene id: 9597:DYNC1LI1
uniprot id: A0A2R9BEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9597:DNM3
gene id: 9597:DNM3
uniprot id: A0A2R9AJZ9
uniprot id: A0A2R9ALU9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9597:NXPH1
gene id: 9597:NXPH1
uniprot id: A0A2R9B5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9597:SLC25A34
gene id: 9597:SLC25A34
uniprot id: A0A2R9CBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:CERT1
gene id: 9597:CERT1
uniprot id: A0A2R9CD16
uniprot id: A0A2R9CD85
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9597:VAMP4
gene id: 9597:VAMP4
uniprot id: A0A2R9A3T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:BPGM
gene id: 9597:BPGM
uniprot id: A0A2R9A0W4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9597:NAPRT
gene id: 9597:NAPRT
uniprot id: A0A2R8ZPA0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9597:LOC100992822
gene id: 9597:LOC100992822
uniprot id: A0A2R8ZN98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ZNF793
gene id: 9597:ZNF793
uniprot id: A0A2R9BMP2
names: Function
messages: May be involved in transcriptional regulation.

9597:VIPAS39
gene id: 9597:VIPAS39
uniprot id: A0A2R9B1T3
uniprot id: A0A2R9B5K9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9597:SLC7A13
gene id: 9597:SLC7A13
uniprot id: A0A2R9B2C4
names: Subcellular Location Annotation
messages: Membrane

9597:F8
gene id: 9597:F8
uniprot id: A0A2R9ATQ4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:RETNLB
gene id: 9597:RETNLB
uniprot id: A0A2R9AYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9597:ABRAXAS2
gene id: 9597:ABRAXAS2
uniprot id: A0A2R9AK64
names: Subcellular Location Annotation
messages: Nucleus

9597:SHC1
gene id: 9597:SHC1
uniprot id: A0A2R9ADH9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:KCNH4
gene id: 9597:KCNH4
uniprot id: A0A2R9BDH4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9597:ALDH3B1
gene id: 9597:ALDH3B1
uniprot id: A0A2R9A9W4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:HOXC5
gene id: 9597:HOXC5
uniprot id: A0A2R9AR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:TGFB3
gene id: 9597:TGFB3
uniprot id: A0A2R9AJT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9597:WNT3
gene id: 9597:WNT3
uniprot id: A0A2R9BL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:HSPA4
gene id: 9597:HSPA4
uniprot id: A0A2R9C712
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9597:MRPS18A
gene id: 9597:MRPS18A
uniprot id: A0A2R9B9W1
uniprot id: A0A2R9BDJ8
names: Subcellular Location Annotation
messages: Mitochondrion

9597:MAPK6
gene id: 9597:MAPK6
uniprot id: A0A2R8ZUR4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9597:ADCK5
gene id: 9597:ADCK5
uniprot id: A0A2R9C0F7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:LOC100992193
gene id: 9597:LOC100992193
uniprot id: A0A2R9CD46
names: Similarity
messages: Belongs to the S-100 family.

9597:THBS3
gene id: 9597:THBS3
uniprot id: A0A2R9CM69
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:FAM168B
gene id: 9597:FAM168B
uniprot id: A0A2R8Z695
names: Similarity
messages: Belongs to the FAM168 family.

9597:TPRG1
gene id: 9597:TPRG1
uniprot id: A0A2R9BYR2
names: Similarity
messages: Belongs to the TPRG1 family.

9597:PDGFB
gene id: 9597:PDGFB
uniprot id: A0A2R9ACQ2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9597:KCNJ6
gene id: 9597:KCNJ6
uniprot id: A0A2R9ASG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9597:LOC100994502
gene id: 9597:LOC100994502
uniprot id: A0A2R8ZAR9
names: Subcellular Location Annotation
messages: Membrane

9597:CRTC2
gene id: 9597:CRTC2
uniprot id: A0A2R9AQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100976120
gene id: 9597:LOC100976120
uniprot id: A0A2R8ZH21
names: Similarity
messages: Belongs to the LCE family.

9597:C4H4orf48
gene id: 9597:C4H4orf48
uniprot id: A0A2R9C9L1
names: Subcellular Location Annotation
messages: Secreted

9597:RABAC1
gene id: 9597:RABAC1
uniprot id: A0A2R9BKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9597:SUCNR1
gene id: 9597:SUCNR1
uniprot id: A0A2R9B0P3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:TENM3
gene id: 9597:TENM3
uniprot id: A0A2R9BL22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ATP2B4
gene id: 9597:ATP2B4
uniprot id: A0A2R9C7M1
uniprot id: A0A2R9CF82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LOC100967539
gene id: 9597:LOC100967539
uniprot id: A0A2R9AYW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:SLC25A39
gene id: 9597:SLC25A39
uniprot id: A0A2R9BZD3
uniprot id: A0A2R9BZD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9597:LRRC8B
gene id: 9597:LRRC8B
uniprot id: A0A2R8ZS38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9597:EIF2A
gene id: 9597:EIF2A
uniprot id: A0A2R9CKE2
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9597:THTPA
gene id: 9597:THTPA
uniprot id: A0A2R8ZVM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9597:DMGDH
gene id: 9597:DMGDH
uniprot id: A0A2R8ZK34
names: Similarity
messages: Belongs to the GcvT family.

9597:LOC100995951
gene id: 9597:LOC100995951
uniprot id: A0A2R9CR28
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.
messages: May be involved in transcriptional regulation.

9597:ICOS
gene id: 9597:ICOS
uniprot id: A0A2R9BIK8
uniprot id: A0A2R9BNB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9597:EBAG9
gene id: 9597:EBAG9
uniprot id: A0A2R9B0N6
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9597:MARCHF4
gene id: 9597:MARCHF4
uniprot id: A0A2R9B6S4
names: Subcellular Location Annotation
messages: Membrane

9597:G6PD
gene id: 9597:G6PD
uniprot id: A0A2R9A9Q3
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9597:ZNF230
gene id: 9597:ZNF230
uniprot id: A0A2R8ZK98
names: Function
messages: May be involved in transcriptional regulation.

9597:MCCC2
gene id: 9597:MCCC2
uniprot id: A0A2R9CTB8
names: Similarity
messages: Belongs to the AccD/PCCB family.

9597:SESN2
gene id: 9597:SESN2
uniprot id: A0A2R9BC26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9597:CDC42EP3
gene id: 9597:CDC42EP3
uniprot id: A0A2R8Z776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9597:HVCN1
gene id: 9597:HVCN1
uniprot id: A0A2R9AXA4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9597:PIANP
gene id: 9597:PIANP
uniprot id: A0A2R9A3V8
names: Subcellular Location Annotation
messages: Membrane

9597:TTYH3
gene id: 9597:TTYH3
uniprot id: A0A2R9BM76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9597:SERP1
gene id: 9597:SERP1
uniprot id: A0A2R8ZNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9597:LOC100993580
gene id: 9597:LOC100993580
uniprot id: A0A2R9A1F7
names: Function
messages: May be involved in transcriptional regulation.

9597:ANO6
gene id: 9597:ANO6
uniprot id: A0A2R9BAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9597:HDAC3
gene id: 9597:HDAC3
uniprot id: A0A2R9BGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9597:GNG3
gene id: 9597:GNG3
uniprot id: A0A2R9ASX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:COQ3
gene id: 9597:COQ3
uniprot id: A0A2R8ZCE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9597:SNX2
gene id: 9597:SNX2
uniprot id: A0A2R9AJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9597:CAPZA1
gene id: 9597:CAPZA1
uniprot id: A0A2R9B1W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9597:ACADSB
gene id: 9597:ACADSB
uniprot id: A0A2R9BHF8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:PANX3
gene id: 9597:PANX3
uniprot id: A0A2R9A6D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9597:GALNT18
gene id: 9597:GALNT18
uniprot id: A0A2R9C0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:PEX3
gene id: 9597:PEX3
uniprot id: A0A2R8ZY46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9597:ACTR2
gene id: 9597:ACTR2
uniprot id: A0A2R9ACM5
uniprot id: A0A2R9AHM0
names: Similarity
messages: Belongs to the actin family.

9597:COPS2
gene id: 9597:COPS2
uniprot id: A0A2R9A5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9597:MAPRE3
gene id: 9597:MAPRE3
uniprot id: A0A2R9B5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9597:CLPS
gene id: 9597:CLPS
uniprot id: A0A2R8ZRN1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9597:KIF23
gene id: 9597:KIF23
uniprot id: A0A2R9BM71
uniprot id: A0A2R9BVE2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:SERPINB10
gene id: 9597:SERPINB10
uniprot id: A0A2R9CEW8
names: Similarity
messages: Belongs to the serpin family.

9597:IL7R
gene id: 9597:IL7R
uniprot id: A0A2R9BVL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9597:STAT3
gene id: 9597:STAT3
uniprot id: A0A2R9CC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9597:TMEM9
gene id: 9597:TMEM9
uniprot id: A0A2R9BPC8
names: Similarity
messages: Belongs to the TMEM9 family.

9597:BEX1
gene id: 9597:BEX1
uniprot id: A0A2R8ZS10
names: Similarity
messages: Belongs to the BEX family.

9597:SKA1
gene id: 9597:SKA1
uniprot id: A0A2R9B3G3
names: Similarity
messages: Belongs to the SKA1 family.

9597:PRMT5
gene id: 9597:PRMT5
uniprot id: A0A2R9AKS4
uniprot id: A0A2R9AQE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9597:PHOSPHO1
gene id: 9597:PHOSPHO1
uniprot id: A0A2R9CFT9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9597:TMEM150B
gene id: 9597:TMEM150B
uniprot id: A0A2R9CAD4
names: Subcellular Location Annotation
messages: Membrane

9597:SEPTIN2
gene id: 9597:SEPTIN2
uniprot id: A0A2R9B3R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9597:NDST3
gene id: 9597:NDST3
uniprot id: A0A2R9AJE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9597:ADAM17
gene id: 9597:ADAM17
uniprot id: A0A2R9BL62
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:KIF20B
gene id: 9597:KIF20B
uniprot id: A0A2R9AGE3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:QPCT
gene id: 9597:QPCT
uniprot id: A0A2R9AL20
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9597:GHITM
gene id: 9597:GHITM
uniprot id: A0A2R8ZEJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:TMEM45A
gene id: 9597:TMEM45A
uniprot id: A0A2R9ASW0
uniprot id: A0A2R9ASW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9597:DPH5
gene id: 9597:DPH5
uniprot id: A0A2R9AF90
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9597:COPS7A
gene id: 9597:COPS7A
uniprot id: A0A2R8ZKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9597:TAF5L
gene id: 9597:TAF5L
uniprot id: A0A2R9AYR3
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9597:LOC100975166
gene id: 9597:LOC100975166
uniprot id: A0A2R9C8K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9597:TGM4
gene id: 9597:TGM4
uniprot id: Q3I1X5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:DNAH3
gene id: 9597:DNAH3
uniprot id: A0A2R9BHZ1
names: Similarity
messages: Belongs to the dynein heavy chain family.

9597:USP49
gene id: 9597:USP49
uniprot id: A0A2R8ZNI6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:ADIPOR2
gene id: 9597:ADIPOR2
uniprot id: A0A2R9B284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:OLFML2B
gene id: 9597:OLFML2B
uniprot id: A0A2R9A075
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SMIM8
gene id: 9597:SMIM8
uniprot id: A0A2R8ZBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9597:SHOX2
gene id: 9597:SHOX2
uniprot id: A0A2R8ZKC9
uniprot id: A0A2R8ZLD6
names: Subcellular Location Annotation
messages: Nucleus

9597:PHF1
gene id: 9597:PHF1
uniprot id: A0A2R9B7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9597:LOC100981494
gene id: 9597:LOC100981494
uniprot id: A0A2R8ZSG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CASP7
gene id: 9597:CASP7
uniprot id: A0A2R9BDG5
uniprot id: A0A2R9BHA8
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:SPEM2
gene id: 9597:SPEM2
uniprot id: A0A2R9BV75
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100992393
gene id: 9597:LOC100992393
uniprot id: A0A2R9AM04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9597:IGF1
gene id: 9597:IGF1
uniprot id: A0A2R8ZF45
uniprot id: A0A2R8ZF48
uniprot id: A0A2R8ZFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9597:BTG2
gene id: 9597:BTG2
uniprot id: A0A2R8Z9Z8
names: Similarity
messages: Belongs to the BTG family.

9597:CHD6
gene id: 9597:CHD6
uniprot id: A0A2R9CLN4
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9597:TRIM9
gene id: 9597:TRIM9
uniprot id: A0A2R9ABM1
names: Subcellular Location Annotation
messages: cytoskeleton

9597:CSN2
gene id: 9597:CSN2
uniprot id: A0A2R8Z5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Secreted

9597:XPO4
gene id: 9597:XPO4
uniprot id: A0A2R9APK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9597:ASRGL1
gene id: 9597:ASRGL1
uniprot id: A0A2R9BKT4
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9597:ZNF114
gene id: 9597:ZNF114
uniprot id: A0A2R9A984
names: Function
messages: May be involved in transcriptional regulation.

9597:FAM47E
gene id: 9597:FAM47E
uniprot id: A0A2R9C295
names: Similarity
messages: Belongs to the FAM47 family.

9597:LOC100975457
gene id: 9597:LOC100975457
uniprot id: A0A2R8ZPD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:EBPL
gene id: 9597:EBPL
uniprot id: A0A2R9CDM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SLC6A20
gene id: 9597:SLC6A20
uniprot id: A0A2R9AZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:TRHR
gene id: 9597:TRHR
uniprot id: A0A2R9BSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9597:WDR12
gene id: 9597:WDR12
uniprot id: A0A2R9AUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9597:PNPO
gene id: 9597:PNPO
uniprot id: A0A2R9BKX3
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9597:C10H10orf53
gene id: 9597:C10H10orf53
uniprot id: A0A2R9AZX4
names: Similarity
messages: Belongs to the UPF0728 family.

9597:PF4V1
gene id: 9597:PF4V1
uniprot id: A0A2R8ZN72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:SNX31
gene id: 9597:SNX31
uniprot id: A0A2R9BTC7
names: Similarity
messages: Belongs to the sorting nexin family.

9597:SCMH1
gene id: 9597:SCMH1
uniprot id: A0A2R9CCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9597:CUL9
gene id: 9597:CUL9
uniprot id: A0A2R9BA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9597:SENP3
gene id: 9597:SENP3
uniprot id: A0A2R8Z9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9597:LOC100977378
gene id: 9597:LOC100977378
uniprot id: A0A2R9BI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:ASB8
gene id: 9597:ASB8
uniprot id: A0A2R9B7R6
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:SLC6A15
gene id: 9597:SLC6A15
uniprot id: A0A2R9CFW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9597:SLC9A8
gene id: 9597:SLC9A8
uniprot id: A0A2R9B3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9597:TPT1
gene id: 9597:TPT1
uniprot id: A0A2R9CBI8
names: Similarity
messages: Belongs to the TCTP family.

9597:GCGR
gene id: 9597:GCGR
uniprot id: A0A2R9AXT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9597:PREPL
gene id: 9597:PREPL
uniprot id: A0A2R9C8X9
names: Similarity
messages: Belongs to the peptidase S9A family.

9597:BCL2A1
gene id: 9597:BCL2A1
uniprot id: A0A2R8ZJX9
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:LOC100993591
gene id: 9597:LOC100993591
uniprot id: A0A2R9A341
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9597:NDUFAF1
gene id: 9597:NDUFAF1
uniprot id: A0A2R9ATC1
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9597:DEDD2
gene id: 9597:DEDD2
uniprot id: A0A2R9CDV1
names: Subcellular Location Annotation
messages: nucleolus

9597:SETDB1
gene id: 9597:SETDB1
uniprot id: A0A2R9CE37
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9597:ESRRG
gene id: 9597:ESRRG
uniprot id: A0A2R9B310
uniprot id: A0A2R9B322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9597:MAPK4
gene id: 9597:MAPK4
uniprot id: A0A2R8ZAT0
uniprot id: A0A2R8ZAU0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9597:CAPNS1
gene id: 9597:CAPNS1
uniprot id: A0A2R9BR52
uniprot id: A0A2R9BR55
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

9597:MYF6
gene id: 9597:MYF6
uniprot id: A0A2R9ALT9
names: Subcellular Location Annotation
messages: Nucleus

9597:PHF5A
gene id: 9597:PHF5A
uniprot id: A0A2R8ZAJ0
names: Similarity
messages: Belongs to the PHF5 family.

9597:PDIA4
gene id: 9597:PDIA4
uniprot id: A0A2R9ALF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9597:SPSB2
gene id: 9597:SPSB2
uniprot id: A0A2R9B822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9597:BIRC3
gene id: 9597:BIRC3
uniprot id: A0A2R9ABF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9597:MGMT
gene id: 9597:MGMT
uniprot id: A0A2R8ZW16
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9597:TPM4
gene id: 9597:TPM4
uniprot id: A0A2R9BYH4
uniprot id: A0A2R9BZ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:COG6
gene id: 9597:COG6
uniprot id: A0A2R9BPS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9597:IGFBP5
gene id: 9597:IGFBP5
uniprot id: A0A2R8ZQV0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:P2RY4
gene id: 9597:P2RY4
uniprot id: A0A2R8Z6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:MTNR1B
gene id: 9597:MTNR1B
uniprot id: A0A2R9ADD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9597:ZNF227
gene id: 9597:ZNF227
uniprot id: A0A2R8Z8L3
names: Function
messages: May be involved in transcriptional regulation.

9597:ZNF223
gene id: 9597:ZNF223
uniprot id: A0A2R8ZKM0
names: Function
messages: May be involved in transcriptional regulation.

9597:CD27
gene id: 9597:CD27
uniprot id: A0A2R9BJU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RPL27A
gene id: 9597:RPL27A
uniprot id: A0A2R9A3H5
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9597:CBFA2T2
gene id: 9597:CBFA2T2
uniprot id: A0A2R9CBX5
names: Similarity
messages: Belongs to the CBFA2T family.

9597:CSN3
gene id: 9597:CSN3
uniprot id: A0A2R9B910
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9597:CHRM5
gene id: 9597:CHRM5
uniprot id: A0A2R8ZEP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9597:ESD
gene id: 9597:ESD
uniprot id: A0A2R9ACC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9597:LSM2
gene id: 9597:LSM2
uniprot id: A0A2R9AS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9597:NPAS1
gene id: 9597:NPAS1
uniprot id: A0A2R9C067
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC2A6
gene id: 9597:SLC2A6
uniprot id: A0A2R9BLP3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9597:TOM1L2
gene id: 9597:TOM1L2
uniprot id: A0A2R8ZNF3
uniprot id: A0A2R8ZRE5
names: Similarity
messages: Belongs to the TOM1 family.

9597:DNASE2B
gene id: 9597:DNASE2B
uniprot id: A0A2R9AF39
names: Similarity
messages: Belongs to the DNase II family.

9597:HTR1B
gene id: 9597:HTR1B
uniprot id: A0A2R8ZF96
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9597:LOC100993556
gene id: 9597:LOC100993556
uniprot id: A0A2R8ZCN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9597:MOS
gene id: 9597:MOS
uniprot id: A0A2R8ZJ46
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:CTNND2
gene id: 9597:CTNND2
uniprot id: A0A2R9AW02
names: Similarity
messages: Belongs to the beta-catenin family.

9597:ARSA
gene id: 9597:ARSA
uniprot id: A0A2R8ZGT3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:POP4
gene id: 9597:POP4
uniprot id: A0A2R9C2Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9597:STAMBPL1
gene id: 9597:STAMBPL1
uniprot id: A0A2R8ZNB1
names: Similarity
messages: Belongs to the peptidase M67C family.

9597:PPDPFL
gene id: 9597:PPDPFL
uniprot id: A0A2R9AS95
names: Similarity
messages: Belongs to the PPDPF family.

9597:TESMIN
gene id: 9597:TESMIN
uniprot id: A0A2R9CCT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9597:DDR2
gene id: 9597:DDR2
uniprot id: A0A2R9ADM8
names: Subcellular Location Annotation
messages: Membrane

9597:NAALADL2
gene id: 9597:NAALADL2
uniprot id: A0A2R9APY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9597:LETM2
gene id: 9597:LETM2
uniprot id: A0A2R8ZNW4
names: Subcellular Location Annotation
messages: Membrane

9597:RANBP17
gene id: 9597:RANBP17
uniprot id: A0A2R9CHP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9597:PUS1
gene id: 9597:PUS1
uniprot id: A0A2R9C3S2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9597:DHX9
gene id: 9597:DHX9
uniprot id: A0A2R9AB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9597:RXRG
gene id: 9597:RXRG
uniprot id: A0A2R9AKU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9597:UGT2A3
gene id: 9597:UGT2A3
uniprot id: A0A2R9AUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:SLC7A2
gene id: 9597:SLC7A2
uniprot id: A0A2R8ZFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9597:MYOZ1
gene id: 9597:MYOZ1
uniprot id: A0A2R8ZU40
names: Similarity
messages: Belongs to the myozenin family.

9597:GYS2
gene id: 9597:GYS2
uniprot id: A0A2R9CAG3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9597:ZNF805
gene id: 9597:ZNF805
uniprot id: A0A2R9BEQ1
names: Function
messages: May be involved in transcriptional regulation.

9597:CBR3
gene id: 9597:CBR3
uniprot id: A0A2R8ZEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9597:ARF3
gene id: 9597:ARF3
uniprot id: A0A2R9AC12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:CCN5
gene id: 9597:CCN5
uniprot id: A0A2R9BBC6
names: Similarity
messages: Belongs to the CCN family.

9597:ZNF667
gene id: 9597:ZNF667
uniprot id: A0A2R9C868
names: Function
messages: May be involved in transcriptional regulation.

9597:CERS5
gene id: 9597:CERS5
uniprot id: A0A2R9B4F4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:DYDC2
gene id: 9597:DYDC2
uniprot id: A0A2R9BBM7
names: Similarity
messages: Belongs to the dpy-30 family.

9597:SLC25A38
gene id: 9597:SLC25A38
uniprot id: A0A2R9AHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9597:KCNMB1
gene id: 9597:KCNMB1
uniprot id: A0A2R9BSK9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9597:CUZD1
gene id: 9597:CUZD1
uniprot id: A0A2R9BQ54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SERINC5
gene id: 9597:SERINC5
uniprot id: A0A2R9BWY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9597:TAS2R50
gene id: 9597:TAS2R50
uniprot id: Q646E4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:GSTCD
gene id: 9597:GSTCD
uniprot id: A0A2R9BT72
names: Similarity
messages: Belongs to the GSTCD family.

9597:TIGD3
gene id: 9597:TIGD3
uniprot id: A0A2R8Z6K9
names: Subcellular Location Annotation
messages: Nucleus

9597:RIC8A
gene id: 9597:RIC8A
uniprot id: A0A2R9C423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9597:APEX2
gene id: 9597:APEX2
uniprot id: A0A2R9B6M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9597:DRAXIN
gene id: 9597:DRAXIN
uniprot id: A0A2R9B931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
messages: Interacts with LRP6.
messages: Secreted

9597:BCAN
gene id: 9597:BCAN
uniprot id: A0A2R9BXM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:LOC100984507
gene id: 9597:LOC100984507
uniprot id: A0A2R8ZYZ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9597:NIPBL
gene id: 9597:NIPBL
uniprot id: A0A2R9BVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9597:SLC35A1
gene id: 9597:SLC35A1
uniprot id: A0A2R9C1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9597:CKAP2L
gene id: 9597:CKAP2L
uniprot id: A0A2R9A109
names: Similarity
messages: Belongs to the CKAP2 family.

9597:LSM7
gene id: 9597:LSM7
uniprot id: A0A2R8ZS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9597:ICAM2
gene id: 9597:ICAM2
uniprot id: A0A2R9B837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9597:GNMT
gene id: 9597:GNMT
uniprot id: A0A2R8ZA16
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9597:TMEM242
gene id: 9597:TMEM242
uniprot id: A0A2R8ZNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9597:ALDH6A1
gene id: 9597:ALDH6A1
uniprot id: A0A2R9AAJ7
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9597:MIPEP
gene id: 9597:MIPEP
uniprot id: A0A2R9A5P6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9597:C4BPA
gene id: 9597:C4BPA
uniprot id: A0A2R9BXJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:IL17B
gene id: 9597:IL17B
uniprot id: A0A2R9AYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:SERPINA3
gene id: 9597:SERPINA3
uniprot id: A0A2R9BT16
names: Similarity
messages: Belongs to the serpin family.

9597:PTPN6
gene id: 9597:PTPN6
uniprot id: A0A2R8ZVQ8
uniprot id: A0A2R8ZWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9597:BTF3L4
gene id: 9597:BTF3L4
uniprot id: A0A2R8ZPI0
names: Similarity
messages: Belongs to the NAC-beta family.

9597:SPCS2
gene id: 9597:SPCS2
uniprot id: A0A2R9A9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100992212
gene id: 9597:LOC100992212
uniprot id: A0A2R8ZRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ERG
gene id: 9597:ERG
uniprot id: A0A2R9ACP1
uniprot id: A0A2R9ACP5
uniprot id: A0A2R9AHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:PPP1R3C
gene id: 9597:PPP1R3C
uniprot id: A0A2R9CHU8
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9597:EIF1AX
gene id: 9597:EIF1AX
uniprot id: A0A2R9AWQ3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9597:RPS24
gene id: 9597:RPS24
uniprot id: A0A2R9CIG7
uniprot id: A0A2R9CL49
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9597:PIGF
gene id: 9597:PIGF
uniprot id: A0A2R9CCW6
uniprot id: A0A2R9CD35
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:NR5A1
gene id: 9597:NR5A1
uniprot id: A0A2R9AVM2
uniprot id: A0A2R9B1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9597:NHSL1
gene id: 9597:NHSL1
uniprot id: A0A2R9BDC9
uniprot id: A0A2R9BEK9
uniprot id: A0A2R9BH71
names: Similarity
messages: Belongs to the NHS family.

9597:CDC42BPG
gene id: 9597:CDC42BPG
uniprot id: A0A2R9AJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9597:CAMK2D
gene id: 9597:CAMK2D
uniprot id: A0A2R9AEX7
uniprot id: A0A2R9AEY3
uniprot id: A0A2R9AFW6
uniprot id: A0A2R9AJS9
uniprot id: A0A2R9AJT5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9597:FBXO46
gene id: 9597:FBXO46
uniprot id: A0A2R8ZNE1
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9597:MRPL24
gene id: 9597:MRPL24
uniprot id: A0A2R9AZQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9597:TMEM70
gene id: 9597:TMEM70
uniprot id: A0A2R8ZGM5
names: Similarity
messages: Belongs to the TMEM70 family.

9597:ADGRG5
gene id: 9597:ADGRG5
uniprot id: A0A2R9BK49
names: Subcellular Location Annotation
messages: Membrane

9597:ZNF549
gene id: 9597:ZNF549
uniprot id: A0A2R9BS06
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC47A2
gene id: 9597:SLC47A2
uniprot id: A0A2R9CHE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9597:TENT5A
gene id: 9597:TENT5A
uniprot id: A0A2R8ZZJ1
names: Similarity
messages: Belongs to the TENT family.

9597:CSNK1G3
gene id: 9597:CSNK1G3
uniprot id: A0A2R8ZYA3
uniprot id: A0A2R8ZZC9
uniprot id: A0A2R9A278
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9597:CCDC25
gene id: 9597:CCDC25
uniprot id: A0A2R9B6E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9597:TACR3
gene id: 9597:TACR3
uniprot id: A0A2R9AIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:TMEM251
gene id: 9597:TMEM251
uniprot id: A0A2R9B5M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

9597:KRT7
gene id: 9597:KRT7
uniprot id: A0A2R9CJ20
names: Similarity
messages: Belongs to the intermediate filament family.

9597:ZNF670
gene id: 9597:ZNF670
uniprot id: A0A2R9CAD1
names: Function
messages: May be involved in transcriptional regulation.

9597:SIAH3
gene id: 9597:SIAH3
uniprot id: A0A2R9AIW9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9597:BAG6
gene id: 9597:BAG6
uniprot id: A0A2R9A5H6
uniprot id: A0A2R9AA85
uniprot id: A0A2R9AAT5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9597:SLC27A4
gene id: 9597:SLC27A4
uniprot id: A0A2R9C7B4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:SNCB
gene id: 9597:SNCB
uniprot id: A0A2R9B721
names: Similarity
messages: Belongs to the synuclein family.

9597:CMKLR1
gene id: 9597:CMKLR1
uniprot id: A0A2R9AM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9597:KAT2B
gene id: 9597:KAT2B
uniprot id: A0A2R9BZT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

9597:ODF2L
gene id: 9597:ODF2L
uniprot id: A0A2R9BF63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9597:PSMB6
gene id: 9597:PSMB6
uniprot id: A0A2R9CGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:HMBS
gene id: 9597:HMBS
uniprot id: A0A2R8ZI12
names: Similarity
messages: Belongs to the HMBS family.

9597:NDUFB1
gene id: 9597:NDUFB1
uniprot id: A0A2R9CS99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:FUCA1
gene id: 9597:FUCA1
uniprot id: A0A2R9BZA7
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9597:HNF4A
gene id: 9597:HNF4A
uniprot id: A0A2R9BKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:MSTN
gene id: 9597:MSTN
uniprot id: A1C2U7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9597:CLIC1
gene id: 9597:CLIC1
uniprot id: A0A2R9APF0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9597:SGTB
gene id: 9597:SGTB
uniprot id: A0A2R9BWR2
names: Similarity
messages: Belongs to the SGT family.

9597:ZKSCAN1
gene id: 9597:ZKSCAN1
uniprot id: A0A2R9BHM6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:FAM83C
gene id: 9597:FAM83C
uniprot id: A0A2R9BT29
names: Similarity
messages: Belongs to the FAM83 family.

9597:SFXN1
gene id: 9597:SFXN1
uniprot id: A0A2R9BAN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9597:ING2
gene id: 9597:ING2
uniprot id: A0A2R9CAK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9597:NAE1
gene id: 9597:NAE1
uniprot id: A0A2R9C9V5
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9597:SETD7
gene id: 9597:SETD7
uniprot id: A0A2R8ZT30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9597:MMUT
gene id: 9597:MMUT
uniprot id: A0A2R9B0C4
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9597:SULF1
gene id: 9597:SULF1
uniprot id: A0A2R9C694
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:HOOK2
gene id: 9597:HOOK2
uniprot id: A0A2R8ZAL1
uniprot id: A0A2R8ZAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9597:LOC100967885
gene id: 9597:LOC100967885
uniprot id: A0A2R9C9C9
names: Similarity
messages: Belongs to the intermediate filament family.

9597:RPSA
gene id: 9597:RPSA
uniprot id: A0A2R9C257
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9597:PGM2L1
gene id: 9597:PGM2L1
uniprot id: A0A2R9A9G5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9597:PIF1
gene id: 9597:PIF1
uniprot id: A0A2R8ZSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9597:XK
gene id: 9597:XK
uniprot id: A0A2R8ZJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9597:MPC2
gene id: 9597:MPC2
uniprot id: A0A2R9AMQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:PCDH9
gene id: 9597:PCDH9
uniprot id: A0A2R9BNL0
uniprot id: A0A2R9BS63
names: Subcellular Location Annotation
messages: Membrane

9597:ATP6V1E1
gene id: 9597:ATP6V1E1
uniprot id: A0A2R9BJF0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9597:UTP14A
gene id: 9597:UTP14A
uniprot id: A0A2R9CCD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9597:PHACTR3
gene id: 9597:PHACTR3
uniprot id: A0A2R9BHZ2
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9597:GORAB
gene id: 9597:GORAB
uniprot id: A0A2R8ZZP2
names: Similarity
messages: Belongs to the GORAB family.

9597:SPIN1
gene id: 9597:SPIN1
uniprot id: A0A2R9A2A6
uniprot id: A0A2R9A2D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9597:P2RX7
gene id: 9597:P2RX7
uniprot id: A0A2R8ZH19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:FOXR1
gene id: 9597:FOXR1
uniprot id: A0A2R9C2J2
names: Subcellular Location Annotation
messages: Nucleus

9597:PTAFR
gene id: 9597:PTAFR
uniprot id: A0A2R8ZQA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9597:EXTL2
gene id: 9597:EXTL2
uniprot id: A0A2R9BBV1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:OPRM1
gene id: 9597:OPRM1
uniprot id: A0A2R9C8J8
uniprot id: A0A2R9C8X0
uniprot id: A0A2R9CJD0
uniprot id: A0A2R9CJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9597:SLC12A8
gene id: 9597:SLC12A8
uniprot id: A0A2R9CIT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9597:LOC100978488
gene id: 9597:LOC100978488
uniprot id: A0A2R8ZN32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:KIF5C
gene id: 9597:KIF5C
uniprot id: A0A2R9AM90
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:SMAD5
gene id: 9597:SMAD5
uniprot id: A0A2R9BFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:TSPAN12
gene id: 9597:TSPAN12
uniprot id: A0A2R9AU53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:ACO1
gene id: 9597:ACO1
uniprot id: A0A2R9ATW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9597:PGK2
gene id: 9597:PGK2
uniprot id: A0A2R8ZF46
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9597:LOC100977039
gene id: 9597:LOC100977039
uniprot id: A0A2R9C528
names: Similarity
messages: Belongs to the villin/gelsolin family.

9597:SMIM7
gene id: 9597:SMIM7
uniprot id: A0A2R9BHA4
names: Similarity
messages: Belongs to the SMIM7 family.

9597:LTB4R
gene id: 9597:LTB4R
uniprot id: A0A2R8ZDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:GSX1
gene id: 9597:GSX1
uniprot id: A0A2R9AN76
names: Subcellular Location Annotation
messages: Nucleus

9597:SZRD1
gene id: 9597:SZRD1
uniprot id: A0A2R9AJF1
uniprot id: A0A2R9ARK1
names: Similarity
messages: Belongs to the SZRD1 family.

9597:SLC10A6
gene id: 9597:SLC10A6
uniprot id: A0A2R8Z9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:RHBDD3
gene id: 9597:RHBDD3
uniprot id: A0A2R9BIW6
names: Subcellular Location Annotation
messages: Membrane

9597:CEP162
gene id: 9597:CEP162
uniprot id: A0A2R8ZUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9597:SSR2
gene id: 9597:SSR2
uniprot id: A0A2R9BCX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9597:ZP1
gene id: 9597:ZP1
uniprot id: A0A2R9B9H1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9597:EDC4
gene id: 9597:EDC4
uniprot id: A0A2R9AW25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9597:CRKL
gene id: 9597:CRKL
uniprot id: A0A2R8ZJE4
names: Similarity
messages: Belongs to the CRK family.

9597:RABEP1
gene id: 9597:RABEP1
uniprot id: A0A2R9AHB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9597:BAZ2A
gene id: 9597:BAZ2A
uniprot id: A0A2R8Z828
uniprot id: A0A2R8ZBN1
uniprot id: A0A2R8ZBP4
names: Similarity
messages: Belongs to the WAL family.

9597:SOD1
gene id: 9597:SOD1
uniprot id: A0A2R8ZYG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9597:LOC103785869
gene id: 9597:LOC103785869
uniprot id: A0A2R8ZBZ8
names: Similarity
messages: Belongs to the LCE family.

9597:EXOSC8
gene id: 9597:EXOSC8
uniprot id: A0A2R8ZU31
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LOC100993752
gene id: 9597:LOC100993752
uniprot id: A0A2R8ZIC3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:EFHC1
gene id: 9597:EFHC1
uniprot id: A0A2R8ZBJ6
uniprot id: A0A2R8ZBM0
names: Subcellular Location Annotation
messages: cilium axoneme

9597:KLHL36
gene id: 9597:KLHL36
uniprot id: A0A2R9BDI1
names: Function
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:TAMM41
gene id: 9597:TAMM41
uniprot id: A0A2R9BLU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9597:ZNF747
gene id: 9597:ZNF747
uniprot id: A0A2R9BTQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:PSMA4
gene id: 9597:PSMA4
uniprot id: A0A2R8ZRW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:MTMR10
gene id: 9597:MTMR10
uniprot id: A0A2R9A333
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:MLH1
gene id: 9597:MLH1
uniprot id: A0A2R9AM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9597:MOGAT3
gene id: 9597:MOGAT3
uniprot id: A0A2R9CLU9
uniprot id: A0A2R9CS57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GPLD1
gene id: 9597:GPLD1
uniprot id: A0A2R9CD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9597:WNT1
gene id: 9597:WNT1
uniprot id: A0A2R8ZPY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:GNAT3
gene id: 9597:GNAT3
uniprot id: A0A2R8ZVH6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:PLA2G2F
gene id: 9597:PLA2G2F
uniprot id: A0A2R8ZZ19
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:GLB1
gene id: 9597:GLB1
uniprot id: A0A2R9BMT9
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9597:HAPLN3
gene id: 9597:HAPLN3
uniprot id: A0A2R9B9J9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:UBQLN2
gene id: 9597:UBQLN2
uniprot id: A0A2R8ZET7
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9597:CHM
gene id: 9597:CHM
uniprot id: A0A2R9B236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9597:TBXT
gene id: 9597:TBXT
uniprot id: A0A2R9A9Z3
uniprot id: A0A2R9AA09
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:LOC100971082
gene id: 9597:LOC100971082
uniprot id: A0A2R8ZSV3
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9597:SERPINA10
gene id: 9597:SERPINA10
uniprot id: A0A2R9BG71
names: Similarity
messages: Belongs to the serpin family.

9597:ATP6V1G1
gene id: 9597:ATP6V1G1
uniprot id: A0A2R8ZA04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:LOC100978249
gene id: 9597:LOC100978249
uniprot id: A0A2R9AVL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9597:NAPEPLD
gene id: 9597:NAPEPLD
uniprot id: A0A2R9BCK2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9597:CLRN2
gene id: 9597:CLRN2
uniprot id: A0A2R8ZV37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9597:CLCNKA
gene id: 9597:CLCNKA
uniprot id: A0A2R9CMD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MEA1
gene id: 9597:MEA1
uniprot id: A0A2R9CF16
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9597:ABAT
gene id: 9597:ABAT
uniprot id: A0A2R8Z656
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9597:ERLIN1
gene id: 9597:ERLIN1
uniprot id: A0A2R9BCK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9597:DST
gene id: 9597:DST
uniprot id: A0A2R8ZLJ5
names: Subcellular Location Annotation
messages: cytoskeleton

9597:POLR3B
gene id: 9597:POLR3B
uniprot id: A0A2R9B527
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9597:PLET1
gene id: 9597:PLET1
uniprot id: A0A2R8ZTB7
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

9597:LAMA1
gene id: 9597:LAMA1
uniprot id: A0A2R9AFC7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:KRT13
gene id: 9597:KRT13
uniprot id: A0A2R8ZB46
uniprot id: A0A2R8ZHV6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:CRPPA
gene id: 9597:CRPPA
uniprot id: A0A2R9AYY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9597:KCNA2
gene id: 9597:KCNA2
uniprot id: A0A2R8ZH38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9597:MFSD4A
gene id: 9597:MFSD4A
uniprot id: A0A2R9A5Y7
names: Subcellular Location Annotation
messages: Membrane

9597:ZNF41
gene id: 9597:ZNF41
uniprot id: A0A2R9B6G9
names: Function
messages: May be involved in transcriptional regulation.

9597:UTP11
gene id: 9597:UTP11
uniprot id: A0A2R9A9M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9597:LOC100972442
gene id: 9597:LOC100972442
uniprot id: A0A2R9A9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9597:SKI
gene id: 9597:SKI
uniprot id: A0A2R9AH64
names: Similarity
messages: Belongs to the SKI family.

9597:NEK7
gene id: 9597:NEK7
uniprot id: A0A2R9A9G9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:LOC100988671
gene id: 9597:LOC100988671
uniprot id: A0A2R8Z7U5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:EDIL3
gene id: 9597:EDIL3
uniprot id: A0A2R9B167
uniprot id: A0A2R9B1E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MRPL58
gene id: 9597:MRPL58
uniprot id: A0A2R9AR27
names: Subcellular Location Annotation
messages: Mitochondrion

9597:BMX
gene id: 9597:BMX
uniprot id: A0A2R9BZZ3
uniprot id: A0A2R9C9H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:ERLEC1
gene id: 9597:ERLEC1
uniprot id: A0A2R9C749
uniprot id: A0A2R9C9X8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9597:RTBDN
gene id: 9597:RTBDN
uniprot id: A0A2R8ZNL9
uniprot id: A0A2R8ZPX1
names: Similarity
messages: Belongs to the folate receptor family.

9597:TIMP4
gene id: 9597:TIMP4
uniprot id: A0A2R9B8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9597:AARS1
gene id: 9597:AARS1
uniprot id: A0A2R9C0B8
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9597:SLC25A53
gene id: 9597:SLC25A53
uniprot id: A0A2R8ZKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:CLPTM1
gene id: 9597:CLPTM1
uniprot id: A0A2R9BVV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9597:API5
gene id: 9597:API5
uniprot id: A0A2R9B4I5
names: Similarity
messages: Belongs to the API5 family.

9597:GFUS
gene id: 9597:GFUS
uniprot id: A0A2R9A8H5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9597:TASP1
gene id: 9597:TASP1
uniprot id: A0A2R9C3Z2
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9597:UTS2
gene id: 9597:UTS2
uniprot id: A0A2R9A5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9597:BTD
gene id: 9597:BTD
uniprot id: A0A2R9B734
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:DEGS2
gene id: 9597:DEGS2
uniprot id: A0A2R9AXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:DGLUCY
gene id: 9597:DGLUCY
uniprot id: A0A2R9AQG9
uniprot id: A0A2R9AQH5
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9597:CCT3
gene id: 9597:CCT3
uniprot id: A0A2R9CAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:SND1
gene id: 9597:SND1
uniprot id: A0A2R9CFY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9597:SMPDL3A
gene id: 9597:SMPDL3A
uniprot id: A0A2R8ZKG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9597:MYO9A
gene id: 9597:MYO9A
uniprot id: A0A2R9BBY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

9597:LOC100980195
gene id: 9597:LOC100980195
uniprot id: A0A2R8ZJC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:EMC3
gene id: 9597:EMC3
uniprot id: A0A2R9C5S0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9597:RPL19
gene id: 9597:RPL19
uniprot id: A0A2R9B688
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9597:STK10
gene id: 9597:STK10
uniprot id: A0A2R8ZGP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9597:RNF34
gene id: 9597:RNF34
uniprot id: A0A2R8ZBE4
names: Subcellular Location Annotation
messages: Cell membrane

9597:UHRF1
gene id: 9597:UHRF1
uniprot id: A0A2R9BE36
names: Subcellular Location Annotation
messages: Nucleus

9597:F11R
gene id: 9597:F11R
uniprot id: A0A2R8ZLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:TACC2
gene id: 9597:TACC2
uniprot id: A0A2R9BPI3
uniprot id: A0A2R9BST9
uniprot id: A0A2R9BT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9597:GAR1
gene id: 9597:GAR1
uniprot id: A0A2R8ZEA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9597:B9D1
gene id: 9597:B9D1
uniprot id: A0A2R8ZVX6
names: Subcellular Location Annotation
messages: cilium basal body

9597:GINS3
gene id: 9597:GINS3
uniprot id: A0A2R9B3W8
uniprot id: A0A2R9B3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9597:PTCD3
gene id: 9597:PTCD3
uniprot id: A0A2R9A0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9597:DNPEP
gene id: 9597:DNPEP
uniprot id: A0A2R9ARD6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9597:NFYA
gene id: 9597:NFYA
uniprot id: A0A2R9C7U1
uniprot id: A0A2R9CID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9597:GABRE
gene id: 9597:GABRE
uniprot id: A0A2R8ZSJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:IFI6
gene id: 9597:IFI6
uniprot id: A0A2R9AKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9597:MAP1LC3C
gene id: 9597:MAP1LC3C
uniprot id: A0A2R8ZQI5
names: Similarity
messages: Belongs to the ATG8 family.

9597:MBTPS2
gene id: 9597:MBTPS2
uniprot id: A0A2R9ARM8
names: Similarity
messages: Belongs to the peptidase M50A family.

9597:KEF42 p08
gene id: 9597:KEF42_p08
uniprot id: E0XIA0
uniprot id: Q9T9W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9597:NPY
gene id: 9597:NPY
uniprot id: A0A2R8ZG61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9597:LOC100974017
gene id: 9597:LOC100974017
uniprot id: A0A2R8ZT84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TAS2R13
gene id: 9597:TAS2R13
uniprot id: Q646D8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:DPH3
gene id: 9597:DPH3
uniprot id: A0A2R9ALH4
uniprot id: A0A2R9ALI2
names: Similarity
messages: Belongs to the DPH3 family.

9597:MRPS18C
gene id: 9597:MRPS18C
uniprot id: A0A2R9BEQ3
uniprot id: A0A2R9BIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9597:NACC1
gene id: 9597:NACC1
uniprot id: A0A2R9B064
names: Subcellular Location Annotation
messages: Nucleus

9597:TATDN1
gene id: 9597:TATDN1
uniprot id: A0A2R9AMK9
uniprot id: A0A2R9AS25
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9597:PLXNA1
gene id: 9597:PLXNA1
uniprot id: A0A2R9CJ22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:VANGL2
gene id: 9597:VANGL2
uniprot id: A0A2R8ZHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9597:LOC100973935
gene id: 9597:LOC100973935
uniprot id: A0A2R8ZIK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100980944
gene id: 9597:LOC100980944
uniprot id: A0A2R8ZUW8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:AP1B1
gene id: 9597:AP1B1
uniprot id: A0A2R9ATU6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:SULF2
gene id: 9597:SULF2
uniprot id: A0A2R9A7N9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:APOL6
gene id: 9597:APOL6
uniprot id: A0A2R9BVD4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:LOC100984887
gene id: 9597:LOC100984887
uniprot id: A0A2R9CC68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:PPY
gene id: 9597:PPY
uniprot id: A0A2R9BJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9597:SEPHS1
gene id: 9597:SEPHS1
uniprot id: A0A2R9BTM4
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9597:RBP4
gene id: 9597:RBP4
uniprot id: A0A2R9C9Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9597:HACL1
gene id: 9597:HACL1
uniprot id: A0A2R9CEC8
names: Similarity
messages: Belongs to the TPP enzyme family.

9597:CAMK1
gene id: 9597:CAMK1
uniprot id: A0A2R9B175
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:CMTR1
gene id: 9597:CMTR1
uniprot id: A0A2R9B885
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9597:LOC100990096
gene id: 9597:LOC100990096
uniprot id: A0A2R9B9J3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:OGN
gene id: 9597:OGN
uniprot id: A0A2R9C3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9597:CDK2AP2
gene id: 9597:CDK2AP2
uniprot id: A0A2R9CG83
names: Similarity
messages: Belongs to the CDK2AP family.

9597:DOHH
gene id: 9597:DOHH
uniprot id: A0A2R8Z868
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9597:LOC100985735
gene id: 9597:LOC100985735
uniprot id: A0A2R9AUA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SDR9C7
gene id: 9597:SDR9C7
uniprot id: A0A2R8Z9Y3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:ZNF184
gene id: 9597:ZNF184
uniprot id: A0A2R9C8X5
names: Function
messages: May be involved in transcriptional regulation.

9597:TMEM151A
gene id: 9597:TMEM151A
uniprot id: A0A2R9AY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9597:P2RX6
gene id: 9597:P2RX6
uniprot id: A0A2R9AU12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:MMP7
gene id: 9597:MMP7
uniprot id: A0A2R9AZJ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9597:SEPTIN8
gene id: 9597:SEPTIN8
uniprot id: A0A2R8ZID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9597:ETNPPL
gene id: 9597:ETNPPL
uniprot id: A0A2R9AQ91
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:ZNF470
gene id: 9597:ZNF470
uniprot id: A0A2R9C2R2
names: Function
messages: May be involved in transcriptional regulation.

9597:SCRN1
gene id: 9597:SCRN1
uniprot id: A0A2R8ZIV2
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9597:PSMA1
gene id: 9597:PSMA1
uniprot id: A0A2R8ZB28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus

9597:DDA1
gene id: 9597:DDA1
uniprot id: A0A2R9C6K3
names: Similarity
messages: Belongs to the DDA1 family.

9597:LOC100976754
gene id: 9597:LOC100976754
uniprot id: A0A2R9C0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9597:KLHL15
gene id: 9597:KLHL15
uniprot id: A0A2R9C0D9
names: Subcellular Location Annotation
messages: Nucleus

9597:APRT
gene id: 9597:APRT
uniprot id: A0A2R8ZCU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9597:SLC19A2
gene id: 9597:SLC19A2
uniprot id: A0A2R9CL39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9597:LOC100993710
gene id: 9597:LOC100993710
uniprot id: A0A2R9CCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9597:TSPAN6
gene id: 9597:TSPAN6
uniprot id: A0A2R9BMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:LOC100989541
gene id: 9597:LOC100989541
uniprot id: A0A2R9C2V2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9597:ANTXR2
gene id: 9597:ANTXR2
uniprot id: A0A2R9C7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9597:PELO
gene id: 9597:PELO
uniprot id: A0A2R9C046
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

9597:NDUFA12
gene id: 9597:NDUFA12
uniprot id: A0A2R8ZLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:DNAAF2
gene id: 9597:DNAAF2
uniprot id: A0A2R9CEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9597:KRT20
gene id: 9597:KRT20
uniprot id: A0A2R9AN97
names: Similarity
messages: Belongs to the intermediate filament family.

9597:PDCD10
gene id: 9597:PDCD10
uniprot id: A0A2R9AWY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9597:MUSTN1
gene id: 9597:MUSTN1
uniprot id: A0A2R9ANR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9597:SLC1A2
gene id: 9597:SLC1A2
uniprot id: A0A2R9AD14
uniprot id: A0A2R9AD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:SPRTN
gene id: 9597:SPRTN
uniprot id: A0A2R9BCR3
uniprot id: A0A2R9BGJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9597:TDRD3
gene id: 9597:TDRD3
uniprot id: A0A2R8ZI96
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9597:LDHC
gene id: 9597:LDHC
uniprot id: A0A2R9BKE8
uniprot id: A0A2R9BUA1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:TMCC2
gene id: 9597:TMCC2
uniprot id: A0A2R9ADG7
names: Similarity
messages: Belongs to the TEX28 family.

9597:SYK
gene id: 9597:SYK
uniprot id: A0A2R9BI29
uniprot id: A0A2R9BI34
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9597:NR0B2
gene id: 9597:NR0B2
uniprot id: A0A2R9BTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9597:SLC33A1
gene id: 9597:SLC33A1
uniprot id: A0A2R9A788
names: Subcellular Location Annotation
messages: Membrane

9597:PTDSS1
gene id: 9597:PTDSS1
uniprot id: A0A2R9C088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CACFD1
gene id: 9597:CACFD1
uniprot id: A0A2R8ZCF5
uniprot id: A0A2R8ZCX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9597:TET3
gene id: 9597:TET3
uniprot id: A0A2R9AGG0
uniprot id: A0A2R9AHE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9597:RBM8A
gene id: 9597:RBM8A
uniprot id: A0A2R9A8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9597:LOC100978493
gene id: 9597:LOC100978493
uniprot id: A0A2R8Z9L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:C6
gene id: 9597:C6
uniprot id: A0A2R9B8Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:ZNF136
gene id: 9597:ZNF136
uniprot id: A0A2R8ZEJ9
names: Function
messages: May be involved in transcriptional regulation.

9597:KIZ
gene id: 9597:KIZ
uniprot id: A0A2R9AEV3
uniprot id: A0A2R9ALG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9597:VPS35L
gene id: 9597:VPS35L
uniprot id: A0A2R9A304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9597:HKDC1
gene id: 9597:HKDC1
uniprot id: A0A2R9B419
names: Similarity
messages: Belongs to the hexokinase family.

9597:GOLT1B
gene id: 9597:GOLT1B
uniprot id: A0A2R9AI84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9597:LOC100968236
gene id: 9597:LOC100968236
uniprot id: A0A2R9ANL2
names: Similarity
messages: Belongs to the intermediate filament family.

9597:CSK
gene id: 9597:CSK
uniprot id: A0A2R9A3Q5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:RAB3IP
gene id: 9597:RAB3IP
uniprot id: A0A2R9BQJ4
names: Similarity
messages: Belongs to the SEC2 family.

9597:ZDHHC5
gene id: 9597:ZDHHC5
uniprot id: A0A2R9BMP4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:INPP4B
gene id: 9597:INPP4B
uniprot id: A0A2R9CP85
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9597:ACSL1
gene id: 9597:ACSL1
uniprot id: A0A2R9B8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9597:ARF1
gene id: 9597:ARF1
uniprot id: A0A2R9ABQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:CNTNAP4
gene id: 9597:CNTNAP4
uniprot id: A0A2R8ZDR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LOC103782690
gene id: 9597:LOC103782690
uniprot id: A0A2R9A572
names: Function
messages: May be involved in transcriptional regulation.

9597:LHFPL4
gene id: 9597:LHFPL4
uniprot id: A0A2R9CK12
names: Subcellular Location Annotation
messages: Membrane

9597:MAP2K5
gene id: 9597:MAP2K5
uniprot id: A0A2R9BFH4
uniprot id: A0A2R9BI59
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:NLN
gene id: 9597:NLN
uniprot id: A0A2R9CP99
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9597:FRZB
gene id: 9597:FRZB
uniprot id: A0A2R9ANQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9597:MRPL44
gene id: 9597:MRPL44
uniprot id: A0A2R9AMW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9597:KIF1B
gene id: 9597:KIF1B
uniprot id: A0A2R9CDS6
uniprot id: A0A2R9CDT7
uniprot id: A0A2R9CDU5
uniprot id: A0A2R9CDW5
uniprot id: A0A2R9CGG4
uniprot id: A0A2R9CP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9597:LOC100992356
gene id: 9597:LOC100992356
uniprot id: A0A2R8ZHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SLC25A43
gene id: 9597:SLC25A43
uniprot id: A0A2R9BYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ZNF680
gene id: 9597:ZNF680
uniprot id: A0A2R9BDE4
names: Function
messages: May be involved in transcriptional regulation.

9597:SCUBE3
gene id: 9597:SCUBE3
uniprot id: A0A2R9CN24
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:ZNF354C
gene id: 9597:ZNF354C
uniprot id: A0A2R9C8V9
names: Function
messages: May be involved in transcriptional regulation.

9597:OSBPL3
gene id: 9597:OSBPL3
uniprot id: A0A2R9AZ81
uniprot id: A0A2R9B046
uniprot id: A0A2R9B2X6
names: Similarity
messages: Belongs to the OSBP family.

9597:TXN
gene id: 9597:TXN
uniprot id: A0A2R9CE55
names: Similarity
messages: Belongs to the thioredoxin family.

9597:HOMER1
gene id: 9597:HOMER1
uniprot id: A0A2R9AR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9597:GRAMD1A
gene id: 9597:GRAMD1A
uniprot id: A0A2R9BW77
uniprot id: A0A2R9BWV0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:IRF8
gene id: 9597:IRF8
uniprot id: A0A2R9B2H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:DMTN
gene id: 9597:DMTN
uniprot id: A0A2R9C6U0
uniprot id: A0A2R9C6W2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:EXOC3
gene id: 9597:EXOC3
uniprot id: A0A2R9AXF8
names: Similarity
messages: Belongs to the SEC6 family.

9597:LPIN3
gene id: 9597:LPIN3
uniprot id: A0A2R9C284
names: Similarity
messages: Belongs to the lipin family.

9597:IPO4
gene id: 9597:IPO4
uniprot id: A0A2R9B574
names: Subcellular Location Annotation
messages: Cytoplasm

9597:CD52
gene id: 9597:CD52
uniprot id: A0A2R9BPG1
names: Function
names: Subcellular Location Annotation
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
messages: Membrane

9597:TMEM45B
gene id: 9597:TMEM45B
uniprot id: A0A2R9AI60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9597:CAVIN4
gene id: 9597:CAVIN4
uniprot id: A0A2R9C9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9597:LOC100981375
gene id: 9597:LOC100981375
uniprot id: A0A2R9AUL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:GNB3
gene id: 9597:GNB3
uniprot id: A0A2R9CF71
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9597:HSDL2
gene id: 9597:HSDL2
uniprot id: A0A2R8Z825
uniprot id: A0A2R8ZEN0
names: Subcellular Location Annotation
messages: Peroxisome

9597:ARF4
gene id: 9597:ARF4
uniprot id: A0A2R9BFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:LIMS2
gene id: 9597:LIMS2
uniprot id: A0A2R9BH15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9597:CDC42SE1
gene id: 9597:CDC42SE1
uniprot id: A0A2R9BGD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9597:FIGN
gene id: 9597:FIGN
uniprot id: A0A2R9ARQ6
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:SLC7A8
gene id: 9597:SLC7A8
uniprot id: A0A2R9A4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9597:PROX1
gene id: 9597:PROX1
uniprot id: A0A2R9B5U5
names: Subcellular Location Annotation
messages: Nucleus

9597:PRXL2A
gene id: 9597:PRXL2A
uniprot id: A0A2R9BP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9597:BUD13
gene id: 9597:BUD13
uniprot id: A0A2R9C569
names: Similarity
messages: Belongs to the CWC26 family.

9597:GSK3B
gene id: 9597:GSK3B
uniprot id: A0A2R9C3U2
uniprot id: A0A2R9C6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9597:ULK3
gene id: 9597:ULK3
uniprot id: A0A2R9AZC8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:GSDMD
gene id: 9597:GSDMD
uniprot id: A0A2R9BZY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9597:MBD4
gene id: 9597:MBD4
uniprot id: A0A2R9BJD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

9597:SLC11A2
gene id: 9597:SLC11A2
uniprot id: A0A2R9BRR9
uniprot id: A0A2R9BRS5
names: Similarity
messages: Belongs to the NRAMP family.

9597:TLE1
gene id: 9597:TLE1
uniprot id: A0A2R9BI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9597:TMEM184B
gene id: 9597:TMEM184B
uniprot id: A0A2R8ZVC9
names: Subcellular Location Annotation
messages: Membrane

9597:PPBP
gene id: 9597:PPBP
uniprot id: A0A2R9CA87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:MSANTD3
gene id: 9597:MSANTD3
uniprot id: A0A2R9AYI9
names: Similarity
messages: Belongs to the MSANTD3 family.

9597:LOC100975275
gene id: 9597:LOC100975275
uniprot id: A0A2R8Z7E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:HIGD1B
gene id: 9597:HIGD1B
uniprot id: A0A2R9BGG4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:VCP
gene id: 9597:VCP
uniprot id: A0A2R9C1U9
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:GMPR2
gene id: 9597:GMPR2
uniprot id: A0A2R9BZM2
uniprot id: A0A2R9C072
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CCT2
gene id: 9597:CCT2
uniprot id: A0A2R8ZJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:CDHR2
gene id: 9597:CDHR2
uniprot id: A0A2R9BF46
names: Subcellular Location Annotation
messages: Membrane

9597:CAPZA3
gene id: 9597:CAPZA3
uniprot id: A0A2R8ZLK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9597:LOC100993874
gene id: 9597:LOC100993874
uniprot id: A0A2R9B1W7
names: Similarity
messages: Belongs to the MS4A family.

9597:MKRN2
gene id: 9597:MKRN2
uniprot id: A0A2R9BCM9
uniprot id: A0A2R9BF16
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:PLA1A
gene id: 9597:PLA1A
uniprot id: A0A2R8ZM37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9597:KLC1
gene id: 9597:KLC1
uniprot id: A0A2R9B9F8
uniprot id: A0A2R9B9R2
uniprot id: A0A2R9BAT1
uniprot id: A0A2R9BH40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9597:XIRP1
gene id: 9597:XIRP1
uniprot id: A0A2R9AE02
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9597:C2BH2orf83
gene id: 9597:C2BH2orf83
uniprot id: A0A2R9A4Y4
names: Similarity
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.

9597:POU1F1
gene id: 9597:POU1F1
uniprot id: A0A2R9BLP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9597:SERPINA5
gene id: 9597:SERPINA5
uniprot id: A0A2R9AU45
names: Similarity
messages: Belongs to the serpin family.

9597:THRSP
gene id: 9597:THRSP
uniprot id: A0A2R8ZKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9597:ANAPC5
gene id: 9597:ANAPC5
uniprot id: A0A2R9AX64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9597:CBX3
gene id: 9597:CBX3
uniprot id: A0A2R9C2U0
names: Subcellular Location Annotation
messages: Nucleus

9597:TLL2
gene id: 9597:TLL2
uniprot id: A0A2R9C077
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RPL10
gene id: 9597:RPL10
uniprot id: A0A2R9AXT4
uniprot id: A0A2R9B361
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9597:MGA
gene id: 9597:MGA
uniprot id: A0A2R9B6R6
uniprot id: A0A2R9B6S2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:SLITRK2
gene id: 9597:SLITRK2
uniprot id: A0A2R8ZTJ6
names: Similarity
messages: Belongs to the SLITRK family.

9597:SLC13A2
gene id: 9597:SLC13A2
uniprot id: A0A2R9AJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9597:CCNE1
gene id: 9597:CCNE1
uniprot id: A0A2R9BYA5
uniprot id: A0A2R9C4N5
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9597:LOC100978630
gene id: 9597:LOC100978630
uniprot id: A0A2R9BUF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9597:FAH
gene id: 9597:FAH
uniprot id: A0A2R9CIB9
names: Similarity
messages: Belongs to the FAH family.

9597:HEPH
gene id: 9597:HEPH
uniprot id: A0A2R9BM31
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:PLP1
gene id: 9597:PLP1
uniprot id: A0A2R8ZMV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9597:ABCB11
gene id: 9597:ABCB11
uniprot id: A0A2R9AU05
names: Subcellular Location Annotation
messages: Endosome

9597:ZSCAN16
gene id: 9597:ZSCAN16
uniprot id: A0A2R9BE49
names: Subcellular Location Annotation
messages: Nucleus

9597:RPS6KA2
gene id: 9597:RPS6KA2
uniprot id: A0A2R9BPU4
uniprot id: A0A2R9BYY6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:CXCL2
gene id: 9597:CXCL2
uniprot id: A0A2R9BNX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:PTPRE
gene id: 9597:PTPRE
uniprot id: A0A2R8ZB11
uniprot id: A0A2R8ZBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9597:SHCBP1
gene id: 9597:SHCBP1
uniprot id: A0A2R9C6W8
names: Subcellular Location Annotation
messages: spindle

9597:LOC100986734
gene id: 9597:LOC100986734
uniprot id: A0A2R9AKZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CTSL
gene id: 9597:CTSL
uniprot id: A0A2R9ACG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:ZNF287
gene id: 9597:ZNF287
uniprot id: A0A2R9AXM9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:UTP6
gene id: 9597:UTP6
uniprot id: A0A2R9BKI9
names: Similarity
messages: Belongs to the UTP6 family.

9597:VIM
gene id: 9597:VIM
uniprot id: A0A2R9BXN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9597:IGF2BP3
gene id: 9597:IGF2BP3
uniprot id: A0A2R9AZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9597:HOXC8
gene id: 9597:HOXC8
uniprot id: A0A2R9ASM5
names: Subcellular Location Annotation
messages: Nucleus

9597:PYROXD1
gene id: 9597:PYROXD1
uniprot id: A0A2R9AJQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9597:ZNF764
gene id: 9597:ZNF764
uniprot id: A0A2R9ABZ5
names: Function
messages: May be involved in transcriptional regulation.

9597:TGFB1
gene id: 9597:TGFB1
uniprot id: A0A2R9AI79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9597:LOC100991705
gene id: 9597:LOC100991705
uniprot id: A0A2R9BUL5
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:ACTL7A
gene id: 9597:ACTL7A
uniprot id: A0A2R8ZG05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9597:SSH2
gene id: 9597:SSH2
uniprot id: A0A2R9ATJ6
uniprot id: A0A2R9AXS9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9597:PAM
gene id: 9597:PAM
uniprot id: A0A2R9A3K2
uniprot id: A0A2R9A917
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9597:SF3B1
gene id: 9597:SF3B1
uniprot id: A0A2R9B2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9597:NANOG
gene id: 9597:NANOG
uniprot id: A0A2R8ZE61
names: Subcellular Location Annotation
messages: Nucleus

9597:CAMK1G
gene id: 9597:CAMK1G
uniprot id: A0A2R9CCR5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MTMR7
gene id: 9597:MTMR7
uniprot id: A0A2R8ZAG8
uniprot id: A0A2R8ZAH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9597:PPP1R12B
gene id: 9597:PPP1R12B
uniprot id: A0A2R8Z7L6
uniprot id: A0A2R8Z7M1
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9597:DLX1
gene id: 9597:DLX1
uniprot id: A0A2R9AKI2
names: Subcellular Location Annotation
messages: Nucleus

9597:KLHL21
gene id: 9597:KLHL21
uniprot id: A0A2R9AC80
names: Subcellular Location Annotation
messages: spindle

9597:ZNF426
gene id: 9597:ZNF426
uniprot id: A0A2R8ZT37
uniprot id: A0A2R8ZUA2
names: Function
messages: May be involved in transcriptional regulation.

9597:NFU1
gene id: 9597:NFU1
uniprot id: A0A2R9BC51
names: Similarity
messages: Belongs to the NifU family.

9597:TMBIM1
gene id: 9597:TMBIM1
uniprot id: A0A2R9AYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane