9595:HTR1F
gene id: 9595:HTR1F
uniprot id: A0A2I2YK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9595:WDR45
gene id: 9595:WDR45
uniprot id: A0A2I2Y3X5
uniprot id: A0A2I2ZFN6
uniprot id: G3QE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

9595:SETD7
gene id: 9595:SETD7
uniprot id: A0A2I2YLY0
uniprot id: G3R7Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9595:PRPF38A
gene id: 9595:PRPF38A
uniprot id: G3QMW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9595:LY75
gene id: 9595:LY75
uniprot id: G3RVS2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SOX21
gene id: 9595:SOX21
uniprot id: G3RV32
names: Subcellular Location Annotation
messages: Nucleus

9595:ART1
gene id: 9595:ART1
uniprot id: G3R210
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9595:CTSB
gene id: 9595:CTSB
uniprot id: G3QFS2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:YIPF6
gene id: 9595:YIPF6
uniprot id: A0A2I2YKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9595:THPO
gene id: 9595:THPO
uniprot id: G3QD04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9595:TMED3
gene id: 9595:TMED3
uniprot id: A0A2I2YSV8
uniprot id: G3R3A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9595:KRT35
gene id: 9595:KRT35
uniprot id: G3RL24
names: Similarity
messages: Belongs to the intermediate filament family.

9595:GOLT1A
gene id: 9595:GOLT1A
uniprot id: G3R6G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9595:SETDB2
gene id: 9595:SETDB2
uniprot id: G3S799
names: Subcellular Location Annotation
messages: Chromosome

9595:LOC101123867
gene id: 9595:LOC101123867
uniprot id: G3RNT7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:NPY2R
gene id: 9595:NPY2R
uniprot id: G3RAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GFM1
gene id: 9595:GFM1
uniprot id: G3QKQ5
uniprot id: G3S1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9595:TBP
gene id: 9595:TBP
uniprot id: G3R850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9595:ATP6V1H
gene id: 9595:ATP6V1H
uniprot id: A0A2I2Z4M8
uniprot id: G3QE24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:LOC101152819
gene id: 9595:LOC101152819
uniprot id: G3RKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RPAIN
gene id: 9595:RPAIN
uniprot id: A0A2I2YA76
uniprot id: A0A2I2YLB4
uniprot id: A0A2I2ZV45
uniprot id: G3QJU6
names: Subcellular Location Annotation
messages: Nucleus

9595:SPX
gene id: 9595:SPX
uniprot id: G3R5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9595:MAP7
gene id: 9595:MAP7
uniprot id: A0A2I2YR22
uniprot id: A0A2I2Z0C0
uniprot id: A0A2I2ZDG0
names: Similarity
messages: Belongs to the MAP7 family.

9595:CCNH
gene id: 9595:CCNH
uniprot id: A0A2I2ZGP3
uniprot id: G3QR33
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9595:LANCL1
gene id: 9595:LANCL1
uniprot id: A0A2I2Z0V7
names: Similarity
messages: Belongs to the LanC-like protein family.

9595:TRDMT1
gene id: 9595:TRDMT1
uniprot id: A0A2I2Y2J7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9595:NNAT
gene id: 9595:NNAT
uniprot id: A0A2I2ZHK7
uniprot id: G3QPM1
names: Similarity
messages: Belongs to the neuronatin family.

9595:LYZL2
gene id: 9595:LYZL2
uniprot id: G3SCD7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9595:UNK
gene id: 9595:UNK
uniprot id: G3R1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9595:LOC101145787
gene id: 9595:LOC101145787
uniprot id: G3QEE1
uniprot id: G3RZY8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.

9595:DHX15
gene id: 9595:DHX15
uniprot id: G3RKY1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9595:USP1
gene id: 9595:USP1
uniprot id: G3S8K7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:SLC29A1
gene id: 9595:SLC29A1
uniprot id: G3QZ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9595:IL18RAP
gene id: 9595:IL18RAP
uniprot id: G3QSS6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:PAM
gene id: 9595:PAM
uniprot id: A0A2I2ZHL5
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9595:DNAH7
gene id: 9595:DNAH7
uniprot id: G3RQK0
names: Similarity
messages: Belongs to the dynein heavy chain family.

9595:ABCG2
gene id: 9595:ABCG2
uniprot id: G3QHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9595:SLCO2B1
gene id: 9595:SLCO2B1
uniprot id: A0A2I2YC36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MRPL49
gene id: 9595:MRPL49
uniprot id: A0A2I2YN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9595:DCP1A
gene id: 9595:DCP1A
uniprot id: G3RAN0
names: Similarity
messages: Belongs to the DCP1 family.

9595:CCT6B
gene id: 9595:CCT6B
uniprot id: A0A2I2ZPT1
uniprot id: G3SDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:PHC1
gene id: 9595:PHC1
uniprot id: G3RWP3
names: Subcellular Location Annotation
messages: Nucleus

9595:SPTA1
gene id: 9595:SPTA1
uniprot id: G3QE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9595:TRADD
gene id: 9595:TRADD
uniprot id: G3R888
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9595:TMEM183A
gene id: 9595:TMEM183A
uniprot id: G3R2Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9595:LGSN
gene id: 9595:LGSN
uniprot id: A0A2I2ZYV7
uniprot id: G3QMX0
names: Similarity
messages: Belongs to the glutamine synthetase family.

9595:SEPTIN3
gene id: 9595:SEPTIN3
uniprot id: G3R0S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:SPP2
gene id: 9595:SPP2
uniprot id: G3QUX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9595:CCT5
gene id: 9595:CCT5
uniprot id: G3SG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:TRIM36
gene id: 9595:TRIM36
uniprot id: A0A2I2Z3J5
uniprot id: G3RKS5
names: Subcellular Location Annotation
messages: cytoskeleton

9595:EMP1
gene id: 9595:EMP1
uniprot id: G3SHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9595:LHX8
gene id: 9595:LHX8
uniprot id: G3RXH8
names: Subcellular Location Annotation
messages: Nucleus

9595:EIF4E
gene id: 9595:EIF4E
uniprot id: A0A2I2YJ03
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9595:LOC101154093
gene id: 9595:LOC101154093
uniprot id: G3RH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9595:EDNRA
gene id: 9595:EDNRA
uniprot id: G3QEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9595:LOC101142869
gene id: 9595:LOC101142869
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:SMC4
gene id: 9595:SMC4
uniprot id: G3RD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9595:IL26
gene id: 9595:IL26
uniprot id: G3R6F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:CRHBP
gene id: 9595:CRHBP
uniprot id: A0A2I2YML7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9595:VAC14
gene id: 9595:VAC14
uniprot id: G3RBC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9595:ZSCAN9
gene id: 9595:ZSCAN9
uniprot id: A0A2I2Y5J7
names: Subcellular Location Annotation
messages: Nucleus

9595:SMARCAD1
gene id: 9595:SMARCAD1
uniprot id: G3SH01
names: Subcellular Location Annotation
messages: Chromosome

9595:CD44
gene id: 9595:CD44
uniprot id: A0A2I2YTE1
uniprot id: A0A2I2Z590
uniprot id: A0A2I2ZPR8
uniprot id: G3QEY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9595:PDSS2
gene id: 9595:PDSS2
uniprot id: A0A2I2ZV98
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9595:TPST2
gene id: 9595:TPST2
uniprot id: G3QQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9595:SNPH
gene id: 9595:SNPH
uniprot id: G3QLF8
names: Subcellular Location Annotation
messages: Membrane

9595:GSX1
gene id: 9595:GSX1
uniprot id: G3QQN4
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101130182
gene id: 9595:LOC101130182
uniprot id: A0A2I2ZU56
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:CSNK1A1
gene id: 9595:CSNK1A1
uniprot id: A0A2I2ZQU5
uniprot id: G3RDH8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:VWC2L
gene id: 9595:VWC2L
uniprot id: A0A2I2Z2P4
uniprot id: G3RJ39
names: Subcellular Location Annotation
messages: Synapse

9595:DHCR7
gene id: 9595:DHCR7
uniprot id: G3QUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9595:FURIN
gene id: 9595:FURIN
uniprot id: G3QYP4
names: Similarity
messages: Belongs to the peptidase S8 family.

9595:LOC101127473
gene id: 9595:LOC101127473
uniprot id: G3RYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TUBG2
gene id: 9595:TUBG2
uniprot id: A0A2I2YLY1
uniprot id: A0A2I2ZF66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9595:ALDH1A1
gene id: 9595:ALDH1A1
uniprot id: G3QZR0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:TET2
gene id: 9595:TET2
uniprot id: A0A2I2Y4W1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9595:SMIM15
gene id: 9595:SMIM15
uniprot id: A0A2I2Y3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9595:ASB6
gene id: 9595:ASB6
uniprot id: G3QJN5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:LOC101153230
gene id: 9595:LOC101153230
uniprot id: G3QL22
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CCL25
gene id: 9595:CCL25
uniprot id: G3QRC6
names: Subcellular Location Annotation
messages: Secreted

9595:DHX58
gene id: 9595:DHX58
uniprot id: G3QRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9595:AFMID
gene id: 9595:AFMID
uniprot id: G3QVU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

9595:PTPN14
gene id: 9595:PTPN14
uniprot id: G3QF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9595:LOC101144197
gene id: 9595:LOC101144197
uniprot id: G3QKY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9595:LANCL2
gene id: 9595:LANCL2
uniprot id: G3RIV2
names: Similarity
messages: Belongs to the LanC-like protein family.

9595:UIMC1
gene id: 9595:UIMC1
uniprot id: G3RLL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9595:MDGA1
gene id: 9595:MDGA1
uniprot id: G3RYJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SCARB2
gene id: 9595:SCARB2
uniprot id: A0A2I2Y3T2
names: Similarity
messages: Belongs to the CD36 family.

9595:EMC6
gene id: 9595:EMC6
uniprot id: G3R352
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOXL3
gene id: 9595:LOXL3
uniprot id: A0A2I2ZIZ8
uniprot id: G3SHW2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:C4BPB
gene id: 9595:C4BPB
uniprot id: A0A2I2YWR4
uniprot id: G3R971
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TM7SF2
gene id: 9595:TM7SF2
uniprot id: G3QJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9595:DDI1
gene id: 9595:DDI1
uniprot id: G3RAE7
names: Similarity
messages: Belongs to the DDI1 family.

9595:LOC101150218
gene id: 9595:LOC101150218
uniprot id: G3QT71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9595:AUH
gene id: 9595:AUH
uniprot id: G3QML4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:DCLK2
gene id: 9595:DCLK2
uniprot id: A0A2I2YMA6
uniprot id: G3RDR8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9595:EXOSC7
gene id: 9595:EXOSC7
uniprot id: G3RCD6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SH3GLB1
gene id: 9595:SH3GLB1
uniprot id: A0A2I2YIS4
uniprot id: A0A2I2YMI0
uniprot id: A0A2I2Z1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9595:TUBA8
gene id: 9595:TUBA8
uniprot id: A0A2I2Y1Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9595:NTNG1
gene id: 9595:NTNG1
uniprot id: A0A2I2Z1B1
uniprot id: A0A2I2ZTW9
uniprot id: A0A2I2ZWL1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RET
gene id: 9595:RET
uniprot id: G3QLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9595:GLMP
gene id: 9595:GLMP
uniprot id: A0A2I2Z1V4
uniprot id: A0A2I2ZIV1
uniprot id: G3REB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9595:CDKL1
gene id: 9595:CDKL1
uniprot id: A0A2I2ZYD1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SLC27A4
gene id: 9595:SLC27A4
uniprot id: G3RFR1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:TTR
gene id: 9595:TTR
uniprot id: G3S3S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9595:LOC101128883
gene id: 9595:LOC101128883
uniprot id: A0A2I2YL94
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:PSMC4
gene id: 9595:PSMC4
uniprot id: G3QF43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9595:FAM13C
gene id: 9595:FAM13C
uniprot id: A0A2I2ZS22
uniprot id: G3RTH3
names: Similarity
messages: Belongs to the FAM13 family.

9595:ELP5
gene id: 9595:ELP5
uniprot id: G3S9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9595:C12H12orf49
gene id: 9595:C12H12orf49
uniprot id: G3RI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9595:POLR3D
gene id: 9595:POLR3D
uniprot id: G3QWI8
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM132A
gene id: 9595:TMEM132A
uniprot id: G3QZZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9595:EHF
gene id: 9595:EHF
uniprot id: A0A2I2YH19
uniprot id: A0A2I2YI92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:OTUD7B
gene id: 9595:OTUD7B
uniprot id: G3SI66
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:FECH
gene id: 9595:FECH
uniprot id: G3S2X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9595:STARD13
gene id: 9595:STARD13
uniprot id: A0A2I2ZC42
names: Subcellular Location Annotation
messages: Cytoplasm

9595:VPS29
gene id: 9595:VPS29
uniprot id: A0A2I2YR60
uniprot id: G3QU67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9595:FAM3D
gene id: 9595:FAM3D
uniprot id: G3RHF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:PSMB11
gene id: 9595:PSMB11
uniprot id: G3QWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:TMCC2
gene id: 9595:TMCC2
uniprot id: G3S0X2
names: Similarity
messages: Belongs to the TEX28 family.

9595:PTGES3L
gene id: 9595:PTGES3L
uniprot id: A0A2I2Y205
names: Similarity
messages: Belongs to the p23/wos2 family.

9595:C4H4orf47
gene id: 9595:C4H4orf47
uniprot id: G3SH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

9595:CAND2
gene id: 9595:CAND2
uniprot id: G3QFC2
names: Similarity
messages: Belongs to the CAND family.

9595:XKR7
gene id: 9595:XKR7
uniprot id: G3QR93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9595:FKRP
gene id: 9595:FKRP
uniprot id: A0A2I2ZR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9595:GDF2
gene id: 9595:GDF2
uniprot id: G3QSX0
names: Similarity
messages: Belongs to the TGF-beta family.

9595:ZSCAN10
gene id: 9595:ZSCAN10
uniprot id: G3R7W9
names: Subcellular Location Annotation
messages: Nucleus

9595:NKX2-5
gene id: 9595:NKX2-5
uniprot id: G3RLM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9595:NEK7
gene id: 9595:NEK7
uniprot id: A0A2I2ZMH9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:FAM32A
gene id: 9595:FAM32A
uniprot id: G3S291
names: Similarity
messages: Belongs to the FAM32 family.

9595:ALOX12
gene id: 9595:ALOX12
uniprot id: G3R2S7
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PLP2
gene id: 9595:PLP2
uniprot id: G3RTV4
names: Subcellular Location Annotation
messages: Membrane

9595:IRF7
gene id: 9595:IRF7
uniprot id: A0A2I2Z966
uniprot id: G3S813
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:HOXC9
gene id: 9595:HOXC9
uniprot id: G3QTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:KEG83 p05
gene id: 9595:KEG83_p05
uniprot id: G3RWE6
uniprot id: Q34572
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9595:VCL
gene id: 9595:VCL
uniprot id: A0A2I2ZYW7
uniprot id: G3R689
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9595:ITGA4
gene id: 9595:ITGA4
uniprot id: G3S3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:FBXO9
gene id: 9595:FBXO9
uniprot id: A0A2I2YYU6
uniprot id: G3QUI1
names: Subcellular Location Annotation
messages: Cytoplasm

9595:TMEM94
gene id: 9595:TMEM94
uniprot id: G3RUP2
uniprot id: G3SCJ5
names: Subcellular Location Annotation
messages: Membrane

9595:SEC23A
gene id: 9595:SEC23A
uniprot id: G3QFP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:ADPRH
gene id: 9595:ADPRH
uniprot id: G3QR17
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9595:GABRQ
gene id: 9595:GABRQ
uniprot id: G3RJ63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:IL6
gene id: 9595:IL6
uniprot id: A0A2I2ZVU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9595:CASC4
gene id: 9595:CASC4
uniprot id: G3SFZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9595:UTRN
gene id: 9595:UTRN
uniprot id: G3S2D7
names: Subcellular Location Annotation
messages: cytoskeleton

9595:UBALD2
gene id: 9595:UBALD2
uniprot id: G3R841
names: Similarity
messages: Belongs to the UBALD family.

9595:PPIL2
gene id: 9595:PPIL2
uniprot id: G3R2W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9595:CETN1
gene id: 9595:CETN1
uniprot id: G3QG53
names: Similarity
messages: Belongs to the centrin family.

9595:LOC109028938
gene id: 9595:LOC109028938
uniprot id: G3RV74
names: Subcellular Location Annotation
messages: Membrane

9595:CPVL
gene id: 9595:CPVL
uniprot id: G3R230
names: Similarity
messages: Belongs to the peptidase S10 family.

9595:DCBLD2
gene id: 9595:DCBLD2
uniprot id: G3R422
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:VPS37D
gene id: 9595:VPS37D
uniprot id: G3QGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:SLC35A1
gene id: 9595:SLC35A1
uniprot id: G3QT26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9595:RBM8A
gene id: 9595:RBM8A
uniprot id: A0A2I2ZK34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9595:HDAC1
gene id: 9595:HDAC1
uniprot id: G3R7V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9595:CLTC
gene id: 9595:CLTC
uniprot id: G3RZC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9595:PRPH2
gene id: 9595:PRPH2
uniprot id: G3QNA9
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9595:UBE2L3
gene id: 9595:UBE2L3
uniprot id: G3RVY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:CLSTN1
gene id: 9595:CLSTN1
uniprot id: A0A2I2ZCM8
uniprot id: G3SG87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9595:NADK2
gene id: 9595:NADK2
uniprot id: A0A2I2Z7B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9595:ACTC1
gene id: 9595:ACTC1
uniprot id: G3R7H3
names: Similarity
messages: Belongs to the actin family.

9595:MDM2
gene id: 9595:MDM2
uniprot id: A0A2I2ZWM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9595:UBE2C
gene id: 9595:UBE2C
uniprot id: G3S6I6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:FAM13A
gene id: 9595:FAM13A
uniprot id: A0A2I2YCU7
uniprot id: A0A2I2Z1M0
uniprot id: A0A2I2ZIL9
names: Similarity
messages: Belongs to the FAM13 family.

9595:CCR2
gene id: 9595:CCR2
uniprot id: G3RP68
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:NFXL1
gene id: 9595:NFXL1
uniprot id: G3QZI7
names: Similarity
messages: Belongs to the NFX1 family.

9595:LOC101134521
gene id: 9595:LOC101134521
uniprot id: A0A2I2YB31
uniprot id: G3R462
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9595:RNASE1
gene id: 9595:RNASE1
uniprot id: Q8SQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
messages: Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity).
messages: Secreted

9595:TPRA1
gene id: 9595:TPRA1
uniprot id: G3R3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9595:LPAR1
gene id: 9595:LPAR1
uniprot id: G3S1C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9595:ZNF18
gene id: 9595:ZNF18
uniprot id: G3QRQ6
names: Subcellular Location Annotation
messages: Nucleus

9595:FLAD1
gene id: 9595:FLAD1
uniprot id: G3RV92
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9595:PYGL
gene id: 9595:PYGL
uniprot id: G3RNK3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9595:DEDD
gene id: 9595:DEDD
uniprot id: A0A2I2YKS2
names: Subcellular Location Annotation
messages: nucleolus

9595:NRP1
gene id: 9595:NRP1
uniprot id: A0A2I2Y8U2
uniprot id: G3QGL8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:METAP2
gene id: 9595:METAP2
uniprot id: G3R026
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9595:NDUFB4
gene id: 9595:NDUFB4
uniprot id: Q0MQD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:UCN3
gene id: 9595:UCN3
uniprot id: G3RKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9595:TRMT2A
gene id: 9595:TRMT2A
uniprot id: G3QES2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PEX12
gene id: 9595:PEX12
uniprot id: G3QLC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9595:TUBA4A
gene id: 9595:TUBA4A
uniprot id: A0A2I2YM80
uniprot id: A0A2I2YPS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9595:MMP8
gene id: 9595:MMP8
uniprot id: G3R051
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:DRD2
gene id: 9595:DRD2
uniprot id: G3S8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9595:GALNT1
gene id: 9595:GALNT1
uniprot id: G3QVC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:RPE65
gene id: 9595:RPE65
uniprot id: G3R2K3
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9595:PPM1B
gene id: 9595:PPM1B
uniprot id: A0A2I2Z9I2
uniprot id: G3REP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9595:GJB2
gene id: 9595:GJB2
uniprot id: Q8MHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB4. Interacts with CNST (By similarity).
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
messages: gap junction

9595:PSMC1
gene id: 9595:PSMC1
uniprot id: G3R4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9595:B4GALT3
gene id: 9595:B4GALT3
uniprot id: G3QX18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:PPP1R12B
gene id: 9595:PPP1R12B
uniprot id: G3QPB2
uniprot id: G3S5C3
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9595:EXOC8
gene id: 9595:EXOC8
uniprot id: G3S1F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9595:ZFYVE27
gene id: 9595:ZFYVE27
uniprot id: A0A2I2ZRA3
uniprot id: G3SEV8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9595:XIRP1
gene id: 9595:XIRP1
uniprot id: G3RKB7
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9595:DOK4
gene id: 9595:DOK4
uniprot id: A0A2I2ZYZ4
uniprot id: G3R9P0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9595:SHFL
gene id: 9595:SHFL
uniprot id: G3SE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body

9595:PDCL
gene id: 9595:PDCL
uniprot id: G3RC41
names: Similarity
messages: Belongs to the phosducin family.

9595:ERO1A
gene id: 9595:ERO1A
uniprot id: G3RTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9595:LOC101146584
gene id: 9595:LOC101146584
uniprot id: G3S302
uniprot id: G3SFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:PPP1R1C
gene id: 9595:PPP1R1C
uniprot id: G3SHT3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9595:CHST10
gene id: 9595:CHST10
uniprot id: G3R7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:PROM2
gene id: 9595:PROM2
uniprot id: G3QUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9595:E2F3
gene id: 9595:E2F3
uniprot id: G3SFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:RETREG1
gene id: 9595:RETREG1
uniprot id: A0A2I2Y1L7
uniprot id: G3R4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9595:IFI27L2
gene id: 9595:IFI27L2
uniprot id: G3QX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:ZKSCAN1
gene id: 9595:ZKSCAN1
uniprot id: G3QQX3
names: Subcellular Location Annotation
messages: Nucleus

9595:NKX2-2
gene id: 9595:NKX2-2
uniprot id: G3QYG3
names: Subcellular Location Annotation
messages: Nucleus

9595:SNAP47
gene id: 9595:SNAP47
uniprot id: A0A2I2Z1Y1
uniprot id: G3QZE5
names: Similarity
messages: Belongs to the SVAP1 family.

9595:MYCL
gene id: 9595:MYCL
uniprot id: G3QH47
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9595:KEG83 p12
gene id: 9595:KEG83_p12
uniprot id: G3S569
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9595:SYNJ1
gene id: 9595:SYNJ1
uniprot id: A0A2I2Y500
uniprot id: A0A2I2YIF4
uniprot id: G3RIQ1
uniprot id: G3RU85
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9595:ZFYVE9
gene id: 9595:ZFYVE9
uniprot id: G3RAB1
uniprot id: G3SI82
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9595:OLFML2A
gene id: 9595:OLFML2A
uniprot id: G3RY25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IL22
gene id: 9595:IL22
uniprot id: G3R0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9595:VPS37C
gene id: 9595:VPS37C
uniprot id: G3RKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:DNM3
gene id: 9595:DNM3
uniprot id: A0A2I2YL61
uniprot id: G3R025
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9595:MAT1A
gene id: 9595:MAT1A
uniprot id: G3QSU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9595:MAP3K5
gene id: 9595:MAP3K5
uniprot id: G3S3K1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9595:ELAC1
gene id: 9595:ELAC1
uniprot id: G3QJI8
names: Subunit
messages: Homodimer.

9595:CUL5
gene id: 9595:CUL5
uniprot id: G3SHP7
names: Similarity
messages: Belongs to the cullin family.

9595:BRIX1
gene id: 9595:BRIX1
uniprot id: G3QNM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9595:GPR142
gene id: 9595:GPR142
uniprot id: G3RLJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SLCO1B7
gene id: 9595:SLCO1B7
uniprot id: G3QNU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ANXA4
gene id: 9595:ANXA4
uniprot id: G3QI88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9595:H1-3
gene id: 9595:H1-3
uniprot id: G3QW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:JAG1
gene id: 9595:JAG1
uniprot id: G3RXX3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:LOC101145063
gene id: 9595:LOC101145063
uniprot id: G3SI13
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

9595:SRM
gene id: 9595:SRM
uniprot id: G3RPZ5
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9595:SEMA3G
gene id: 9595:SEMA3G
uniprot id: G3RIL7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GGA1
gene id: 9595:GGA1
uniprot id: A0A2I2Z8T1
uniprot id: G3RF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9595:RPL41
gene id: 9595:RPL41
uniprot id: A0A2I2YS91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.
messages: Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

9595:TMEM218
gene id: 9595:TMEM218
uniprot id: G3RHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9595:IFNB1
gene id: 9595:IFNB1
uniprot id: G3RM24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9595:GLIS1
gene id: 9595:GLIS1
uniprot id: A0A2I2Z8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9595:OBP2B
gene id: 9595:OBP2B
uniprot id: G3R204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:HIBCH
gene id: 9595:HIBCH
uniprot id: A0A2I2Z7M5
uniprot id: A0A2I2ZTG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9595:DTNB
gene id: 9595:DTNB
uniprot id: A0A2I2ZG45
uniprot id: A0A2I2ZKZ6
uniprot id: G3QXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9595:LOC101136745
gene id: 9595:LOC101136745
uniprot id: G3R5W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PTCD2
gene id: 9595:PTCD2
uniprot id: G3R562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9595:VRK1
gene id: 9595:VRK1
uniprot id: A0A2I2Y8N8
uniprot id: G3QNA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:CLCN3
gene id: 9595:CLCN3
uniprot id: A0A2I2YUJ8
uniprot id: A0A2I2ZTH4
uniprot id: G3REC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:SLC4A8
gene id: 9595:SLC4A8
uniprot id: A0A2I2ZTX4
uniprot id: G3R9D5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CCT3
gene id: 9595:CCT3
uniprot id: A0A2I2Z9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:MED13
gene id: 9595:MED13
uniprot id: G3R2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:CASP10
gene id: 9595:CASP10
uniprot id: A0A2I2Y8W2
uniprot id: A0A2I2YRX6
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:FOXL1
gene id: 9595:FOXL1
uniprot id: G3RF46
names: Subcellular Location Annotation
messages: Nucleus

9595:NOP10
gene id: 9595:NOP10
uniprot id: G3QFH4
names: Similarity
messages: Belongs to the NOP10 family.

9595:LACC1
gene id: 9595:LACC1
uniprot id: G3R0P4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9595:PPIC
gene id: 9595:PPIC
uniprot id: G3QFM7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:SPDEF
gene id: 9595:SPDEF
uniprot id: A0A2I2YMJ9
uniprot id: G3QDQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:SERP1
gene id: 9595:SERP1
uniprot id: G3RR15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9595:CRYBB3
gene id: 9595:CRYBB3
uniprot id: G3SCP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9595:SCN2A
gene id: 9595:SCN2A
uniprot id: A0A2I2Y832
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:SMC2
gene id: 9595:SMC2
uniprot id: A0A2I2ZG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9595:DOCK7
gene id: 9595:DOCK7
uniprot id: A0A2I2Y2I8
uniprot id: A0A2I2ZJD2
uniprot id: G3QK73
uniprot id: G3S0Q6
names: Similarity
messages: Belongs to the DOCK family.

9595:RPL3
gene id: 9595:RPL3
uniprot id: A0A2I2Y8T8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9595:BICC1
gene id: 9595:BICC1
uniprot id: G3QRW0
names: Similarity
messages: Belongs to the BicC family.

9595:RPL31
gene id: 9595:RPL31
uniprot id: G3QU89
uniprot id: G3SDU2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9595:RPIA
gene id: 9595:RPIA
uniprot id: G3SGC2
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9595:POLR2I
gene id: 9595:POLR2I
uniprot id: G3RHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9595:PDCD5
gene id: 9595:PDCD5
uniprot id: A0A2I2YIR7
uniprot id: G3QTK5
names: Similarity
messages: Belongs to the PDCD5 family.

9595:GPM6B
gene id: 9595:GPM6B
uniprot id: A0A2I2Y331
uniprot id: A0A2I2YQZ7
uniprot id: G3REG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9595:GPR182
gene id: 9595:GPR182
uniprot id: G3RRX4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:RPL7L1
gene id: 9595:RPL7L1
uniprot id: G3S2G9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9595:LYPLA2
gene id: 9595:LYPLA2
uniprot id: G3QNX0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9595:FOXO1
gene id: 9595:FOXO1
uniprot id: G3QYI5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101153788
gene id: 9595:LOC101153788
uniprot id: G3RKU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SLC25A3
gene id: 9595:SLC25A3
uniprot id: G3RII8
uniprot id: G3SET8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9595:OXR1
gene id: 9595:OXR1
uniprot id: A0A2I2YQR4
uniprot id: A0A2I2ZKZ2
uniprot id: G3QTR9
names: Similarity
messages: Belongs to the OXR1 family.

9595:ADAM21
gene id: 9595:ADAM21
uniprot id: G3SAR3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SYNJ2
gene id: 9595:SYNJ2
uniprot id: G3R949
uniprot id: G3RRS3
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9595:GLRA3
gene id: 9595:GLRA3
uniprot id: G3QU31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9595:DAND5
gene id: 9595:DAND5
uniprot id: A0A2I2YQG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9595:NMI
gene id: 9595:NMI
uniprot id: G3RCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9595:DPCD
gene id: 9595:DPCD
uniprot id: G3QQQ9
names: Similarity
messages: Belongs to the DPCD family.

9595:MED4
gene id: 9595:MED4
uniprot id: G3RE20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:ILF3
gene id: 9595:ILF3
uniprot id: A0A2I2YPJ5
uniprot id: G3QNF4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:ASB10
gene id: 9595:ASB10
uniprot id: G3QDI7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:TBK1
gene id: 9595:TBK1
uniprot id: G3S8G6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SNX1
gene id: 9595:SNX1
uniprot id: A0A2I2YF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9595:FCN2
gene id: 9595:FCN2
uniprot id: G3SI20
names: Similarity
messages: Belongs to the ficolin lectin family.

9595:NT5E
gene id: 9595:NT5E
uniprot id: G3QF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9595:LOC101154090
gene id: 9595:LOC101154090
uniprot id: A0A2I2YYX3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:MTURN
gene id: 9595:MTURN
uniprot id: G3QJF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9595:CCDC58
gene id: 9595:CCDC58
uniprot id: A0A2I2ZR55
names: Similarity
messages: Belongs to the MIX23 family.

9595:LOC101151950
gene id: 9595:LOC101151950
uniprot id: G3RZY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9595:GALK2
gene id: 9595:GALK2
uniprot id: A0A2I2YIZ2
uniprot id: A0A2I2ZBW5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9595:MARVELD1
gene id: 9595:MARVELD1
uniprot id: G3SIG2
names: Subcellular Location Annotation
messages: Membrane

9595:RDM1
gene id: 9595:RDM1
uniprot id: A0A2I2YDT7
uniprot id: G3R4V8
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9595:LOC101146257
gene id: 9595:LOC101146257
uniprot id: G3QTP1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:MRPL16
gene id: 9595:MRPL16
uniprot id: G3S6I0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9595:ACTR6
gene id: 9595:ACTR6
uniprot id: G3QEY5
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9595:WSCD2
gene id: 9595:WSCD2
uniprot id: A0A2I2ZK03
names: Similarity
messages: Belongs to the WSCD family.

9595:PREP
gene id: 9595:PREP
uniprot id: G3RLW9
names: Similarity
messages: Belongs to the peptidase S9A family.

9595:CDH6
gene id: 9595:CDH6
uniprot id: G3RLA5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:LOC101136730
gene id: 9595:LOC101136730
uniprot id: G3QFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CDK4
gene id: 9595:CDK4
uniprot id: G3QGD2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ANG
gene id: 9595:ANG
uniprot id: A0A2I2YL38
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9595:RBBP4
gene id: 9595:RBBP4
uniprot id: A0A2I2ZFC8
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101128235
gene id: 9595:LOC101128235
uniprot id: G3QLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CPA3
gene id: 9595:CPA3
uniprot id: G3S533
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:HSD17B2
gene id: 9595:HSD17B2
uniprot id: G3RKG6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:TCTEX1D1
gene id: 9595:TCTEX1D1
uniprot id: G3QIZ5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9595:CA14
gene id: 9595:CA14
uniprot id: G3RLP6
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9595:POMC
gene id: 9595:POMC
uniprot id: G3QLQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

9595:EIF2A
gene id: 9595:EIF2A
uniprot id: A0A2I2YBQ1
uniprot id: A0A2I2ZFS3
uniprot id: A0A2I2ZU84
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9595:GH1
gene id: 9595:GH1
uniprot id: A0A2I2ZCZ5
uniprot id: G3RFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9595:GTF2A2
gene id: 9595:GTF2A2
uniprot id: G3RVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9595:LOC101147253
gene id: 9595:LOC101147253
uniprot id: G3SIR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:SYPL2
gene id: 9595:SYPL2
uniprot id: G3RC44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9595:POFUT2
gene id: 9595:POFUT2
uniprot id: G3RGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9595:TMEM63C
gene id: 9595:TMEM63C
uniprot id: G3QTM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9595:PTCH1
gene id: 9595:PTCH1
uniprot id: A0A2I2ZGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9595:INSM2
gene id: 9595:INSM2
uniprot id: A0A2I2Z1D2
names: Subcellular Location Annotation
messages: Nucleus

9595:PDE1A
gene id: 9595:PDE1A
uniprot id: A0A2I2YVR3
uniprot id: A0A2I2ZIK5
uniprot id: A0A2I2ZTQ4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:CLDN16
gene id: 9595:CLDN16
uniprot id: G3SJW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:GCLM
gene id: 9595:GCLM
uniprot id: G3RJX6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9595:INIP
gene id: 9595:INIP
uniprot id: A0A2I2YNT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9595:LOC101123729
gene id: 9595:LOC101123729
uniprot id: G3QT24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:DUSP7
gene id: 9595:DUSP7
uniprot id: A0A2I2Y1Z9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:STMN2
gene id: 9595:STMN2
uniprot id: G3QQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

9595:AKIRIN2
gene id: 9595:AKIRIN2
uniprot id: G3QJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9595:ACOT4
gene id: 9595:ACOT4
uniprot id: G3QGT1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9595:RAB4A
gene id: 9595:RAB4A
uniprot id: G3RI48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9595:GTF2E2
gene id: 9595:GTF2E2
uniprot id: G3RZT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9595:MRPL12
gene id: 9595:MRPL12
uniprot id: G3R1R2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9595:ASPN
gene id: 9595:ASPN
uniprot id: G3SJH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9595:PLPPR5
gene id: 9595:PLPPR5
uniprot id: G3RQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:MSX1
gene id: 9595:MSX1
uniprot id: G3R151
names: Subcellular Location Annotation
messages: Nucleus

9595:BNIP1
gene id: 9595:BNIP1
uniprot id: G3QIJ2
uniprot id: G3SHW1
names: Subcellular Location Annotation
messages: Membrane

9595:NIT1
gene id: 9595:NIT1
uniprot id: A0A2I2Z833
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9595:GDAP1
gene id: 9595:GDAP1
uniprot id: G3QK24
names: Similarity
messages: Belongs to the GST superfamily.

9595:ATP1B3
gene id: 9595:ATP1B3
uniprot id: G3RSA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9595:TFAP2A
gene id: 9595:TFAP2A
uniprot id: A0A2I2Y2H6
uniprot id: A0A2I2Y342
uniprot id: G3QX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9595:SLC13A5
gene id: 9595:SLC13A5
uniprot id: G3QDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9595:ZDHHC16
gene id: 9595:ZDHHC16
uniprot id: A0A2I2YFV3
uniprot id: A0A2I2Z4U9
uniprot id: A0A2I2ZX16
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:EIF3D
gene id: 9595:EIF3D
uniprot id: G3RM58
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9595:LOC101125954
gene id: 9595:LOC101125954
uniprot id: A0A2I2YDN8
uniprot id: A0A2I2ZQ55
uniprot id: G3RJC8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:LOC101139367
gene id: 9595:LOC101139367
uniprot id: A0A2I2YB08
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:RPRD1B
gene id: 9595:RPRD1B
uniprot id: G3QNP7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9595:MNS1
gene id: 9595:MNS1
uniprot id: G3QPS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9595:EI24
gene id: 9595:EI24
uniprot id: A0A2I2Y9X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9595:SLC25A37
gene id: 9595:SLC25A37
uniprot id: A0A2I2ZXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:PAPSS2
gene id: 9595:PAPSS2
uniprot id: G3SB39
uniprot id: G3SFQ9
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9595:CLDND2
gene id: 9595:CLDND2
uniprot id: G3RFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9595:SPTLC2
gene id: 9595:SPTLC2
uniprot id: G3R898
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9595:EEF1A1
gene id: 9595:EEF1A1
uniprot id: G3S518
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9595:ZNF706
gene id: 9595:ZNF706
uniprot id: A0A2I2Z9V7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:TNFRSF10A
gene id: 9595:TNFRSF10A
uniprot id: A0A2I2ZI00
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9595:LOC101124572
gene id: 9595:LOC101124572
uniprot id: G3S063
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:SOX9
gene id: 9595:SOX9
uniprot id: G3RLX8
names: Subcellular Location Annotation
messages: Nucleus

9595:PRSS36
gene id: 9595:PRSS36
uniprot id: G3S8C7
names: Function
names: Subcellular Location Annotation
messages: Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
messages: extracellular matrix

9595:PPM1N
gene id: 9595:PPM1N
uniprot id: G3QCS8
names: Similarity
messages: Belongs to the PP2C family.

9595:DZIP1L
gene id: 9595:DZIP1L
uniprot id: G3R7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9595:ATAD2
gene id: 9595:ATAD2
uniprot id: G3R1V2
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:LOC101131235
gene id: 9595:LOC101131235
uniprot id: G3S117
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:PAX9
gene id: 9595:PAX9
uniprot id: G3QGP5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9595:MAN2B2
gene id: 9595:MAN2B2
uniprot id: G3QYG2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:NR2C1
gene id: 9595:NR2C1
uniprot id: A0A2I2ZHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:ALOX5AP
gene id: 9595:ALOX5AP
uniprot id: G3RDC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:RSPO2
gene id: 9595:RSPO2
uniprot id: G3S4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9595:FAM53B
gene id: 9595:FAM53B
uniprot id: G3QH12
names: Similarity
messages: Belongs to the FAM53 family.

9595:MED20
gene id: 9595:MED20
uniprot id: G3RJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:IL4R
gene id: 9595:IL4R
uniprot id: G3QKJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9595:ACE2
gene id: 9595:ACE2
uniprot id: G3QWX4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9595:KIF20A
gene id: 9595:KIF20A
uniprot id: G3QW17
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:SCN1A
gene id: 9595:SCN1A
uniprot id: A0A2I2ZQZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:GDE1
gene id: 9595:GDE1
uniprot id: G3QJ60
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:MFSD14B
gene id: 9595:MFSD14B
uniprot id: G3QZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9595:LOC101153606
gene id: 9595:LOC101153606
uniprot id: G3QRG5
names: Similarity
messages: Belongs to the NGF-beta family.

9595:ARRDC5
gene id: 9595:ARRDC5
uniprot id: G3SH71
names: Similarity
messages: Belongs to the arrestin family.

9595:HOXA9
gene id: 9595:HOXA9
uniprot id: G3QIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:LY6G5C
gene id: 9595:LY6G5C
uniprot id: G3R3A3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9595:CHRNA1
gene id: 9595:CHRNA1
uniprot id: A0A2I2ZA95
uniprot id: G3S4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:ACO1
gene id: 9595:ACO1
uniprot id: G3RJN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9595:VPS26B
gene id: 9595:VPS26B
uniprot id: G3QV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9595:ANK3
gene id: 9595:ANK3
uniprot id: A0A2I2Z6M3
uniprot id: G3QMX5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:NDUFS1
gene id: 9595:NDUFS1
uniprot id: A0A2I2ZR47
uniprot id: Q0MQG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Interacts with MDM2 and AKAP1 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).
messages: Mitochondrion inner membrane

9595:TRPM6
gene id: 9595:TRPM6
uniprot id: A0A2I2YAK6
uniprot id: A0A2I2YQ50
uniprot id: G3SJI9
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9595:IPO4
gene id: 9595:IPO4
uniprot id: G3S5I6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LPCAT1
gene id: 9595:LPCAT1
uniprot id: G3RHY4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:MOGAT3
gene id: 9595:MOGAT3
uniprot id: A0A2I2ZL00
uniprot id: G3RKL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:KATNAL1
gene id: 9595:KATNAL1
uniprot id: G3S5S1
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9595:B4GALT7
gene id: 9595:B4GALT7
uniprot id: A0A2I2YRF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:PTHLH
gene id: 9595:PTHLH
uniprot id: A0A2I2Z7L9
uniprot id: G3RRH1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9595:NARF
gene id: 9595:NARF
uniprot id: A0A2I2ZGA6
names: Similarity
messages: Belongs to the NARF family.

9595:SEMA6D
gene id: 9595:SEMA6D
uniprot id: A0A2I2YAP2
uniprot id: A0A2I2YBL3
uniprot id: G3RK95
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MYT1L
gene id: 9595:MYT1L
uniprot id: G3S784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9595:SLC25A11
gene id: 9595:SLC25A11
uniprot id: G3QDA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:LOC101154074
gene id: 9595:LOC101154074
uniprot id: G3R2L4
names: Similarity
messages: Belongs to the intermediate filament family.

9595:SLC34A2
gene id: 9595:SLC34A2
uniprot id: G3SH16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9595:LYPD6B
gene id: 9595:LYPD6B
uniprot id: A0A2I2Z185
uniprot id: G3S101
uniprot id: G3S3G9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SNRNP27
gene id: 9595:SNRNP27
uniprot id: A0A2I2Y8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9595:LIPG
gene id: 9595:LIPG
uniprot id: G3QE94
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:B2M
gene id: 9595:B2M
uniprot id: P61771
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9595:CRYBG2
gene id: 9595:CRYBG2
uniprot id: G3QXJ2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:MRPS11
gene id: 9595:MRPS11
uniprot id: G3RGN4
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9595:INMT
gene id: 9595:INMT
uniprot id: G3QQF8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9595:CFTR
gene id: 9595:CFTR
uniprot id: G3S0G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Recycling endosome membrane

9595:CGA
gene id: 9595:CGA
uniprot id: A0A2I2Y6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

9595:HMGCS2
gene id: 9595:HMGCS2
uniprot id: G3R459
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9595:STX5
gene id: 9595:STX5
uniprot id: G3QHQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9595:PI4KB
gene id: 9595:PI4KB
uniprot id: A0A2I2YAY3
uniprot id: A0A2I2ZJU4
uniprot id: G3RGN7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:GPR183
gene id: 9595:GPR183
uniprot id: G3QEL2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:OVCA2
gene id: 9595:OVCA2
uniprot id: G3R1S1
names: Similarity
messages: Belongs to the LovG family.

9595:TMEM19
gene id: 9595:TMEM19
uniprot id: G3RXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9595:LOC101132797
gene id: 9595:LOC101132797
uniprot id: G3QK89
names: Similarity
messages: Belongs to the peptidase A1 family.

9595:IRGC
gene id: 9595:IRGC
uniprot id: G3S785
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9595:ANAPC2
gene id: 9595:ANAPC2
uniprot id: G3RV64
names: Similarity
messages: Belongs to the cullin family.

9595:ZBED1
gene id: 9595:ZBED1
uniprot id: G3R7R6
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC14A1
gene id: 9595:SLC14A1
uniprot id: G3QYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9595:PTGES2
gene id: 9595:PTGES2
uniprot id: G3SK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9595:NMU
gene id: 9595:NMU
uniprot id: A0A2I2YNU6
uniprot id: A0A2I2ZE22
uniprot id: A0A2I2ZFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9595:AMER3
gene id: 9595:AMER3
uniprot id: G3QSD0
names: Similarity
messages: Belongs to the Amer family.

9595:TRHR
gene id: 9595:TRHR
uniprot id: G3RKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9595:CENPB
gene id: 9595:CENPB
uniprot id: A0A2I2ZG27
names: Subcellular Location Annotation
messages: Nucleus

9595:CLCA2
gene id: 9595:CLCA2
uniprot id: G3QME4
names: Similarity
messages: Belongs to the CLCR family.

9595:LOC101149522
gene id: 9595:LOC101149522
uniprot id: G3RZ91
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9595:UPF3A
gene id: 9595:UPF3A
uniprot id: A0A2I2Y5T4
uniprot id: G3SAR2
names: Similarity
messages: Belongs to the RENT3 family.

9595:GPR68
gene id: 9595:GPR68
uniprot id: G3S4M3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:VARS2
gene id: 9595:VARS2
uniprot id: G3RF77
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:LOC101137192
gene id: 9595:LOC101137192
uniprot id: G3RDS5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:HMGN5
gene id: 9595:HMGN5
uniprot id: G3RK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:PIK3C2G
gene id: 9595:PIK3C2G
uniprot id: A0A2I2Z7Z4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:GLUL
gene id: 9595:GLUL
uniprot id: G3SJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9595:NDUFA7
gene id: 9595:NDUFA7
uniprot id: G3QF48
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9595:PMP2
gene id: 9595:PMP2
uniprot id: G3RTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9595:SGO2
gene id: 9595:SGO2
uniprot id: A0A2I2YSY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9595:FEN1
gene id: 9595:FEN1
uniprot id: G3RA03
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9595:SLC16A4
gene id: 9595:SLC16A4
uniprot id: A0A2I2YLD9
uniprot id: A0A2I2YY37
uniprot id: G3RJW7
names: Subcellular Location Annotation
messages: Membrane

9595:UROC1
gene id: 9595:UROC1
uniprot id: G3S3N4
names: Similarity
messages: Belongs to the urocanase family.

9595:CBX2
gene id: 9595:CBX2
uniprot id: G3R2W1
names: Subcellular Location Annotation
messages: Nucleus

9595:NGB
gene id: 9595:NGB
uniprot id: G3QTM7
names: Similarity
messages: Belongs to the globin family.

9595:DEFB110
gene id: 9595:DEFB110
uniprot id: G3QG52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:TUT7
gene id: 9595:TUT7
uniprot id: G3QX44
uniprot id: G3SAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9595:LSM8
gene id: 9595:LSM8
uniprot id: A0A2I2YFG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9595:SPAM1
gene id: 9595:SPAM1
uniprot id: A0A2I2ZU03
uniprot id: G3QVL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9595:XPO6
gene id: 9595:XPO6
uniprot id: G3QS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9595:ZNF75D
gene id: 9595:ZNF75D
uniprot id: A0A2I2Z4A5
names: Subcellular Location Annotation
messages: Nucleus

9595:ZHX1
gene id: 9595:ZHX1
uniprot id: A1YF22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor.
messages: Belongs to the ZHX family.
messages: Forms homodimers. Also forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2. Interacts with NFYA. Interacts with ATF7IP (By similarity).
messages: Nucleus

9595:SLITRK5
gene id: 9595:SLITRK5
uniprot id: G3S4W5
names: Similarity
messages: Belongs to the SLITRK family.

9595:EIF4A1
gene id: 9595:EIF4A1
uniprot id: G3SGA8
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9595:CITED1
gene id: 9595:CITED1
uniprot id: G3QDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9595:SEPTIN10
gene id: 9595:SEPTIN10
uniprot id: A0A2I2YIZ9
uniprot id: A0A2I2ZL83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:TBX3
gene id: 9595:TBX3
uniprot id: A0A2I2YWL2
uniprot id: G3QNP1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:SLA2
gene id: 9595:SLA2
uniprot id: G3RAU1
names: Subcellular Location Annotation
messages: Cytoplasm

9595:ZC3H12D
gene id: 9595:ZC3H12D
uniprot id: G3QRX9
names: Similarity
messages: Belongs to the ZC3H12 family.

9595:SLC46A2
gene id: 9595:SLC46A2
uniprot id: G3QNM0
names: Subcellular Location Annotation
messages: Membrane

9595:SMAD1
gene id: 9595:SMAD1
uniprot id: G3SBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9595:RARS1
gene id: 9595:RARS1
uniprot id: G3R2H6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:LOC101147404
gene id: 9595:LOC101147404
uniprot id: G3RSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:AFM
gene id: 9595:AFM
uniprot id: G3RCD3
names: Subcellular Location Annotation
messages: Secreted

9595:FEV
gene id: 9595:FEV
uniprot id: G3R5E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:PSMG1
gene id: 9595:PSMG1
uniprot id: A0A2I2ZNL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9595:SCARA5
gene id: 9595:SCARA5
uniprot id: G3QHJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9595:LBR
gene id: 9595:LBR
uniprot id: G3RGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9595:LOC101128237
gene id: 9595:LOC101128237
uniprot id: G3R317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9595:DPYS
gene id: 9595:DPYS
uniprot id: G3QDD2
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9595:ERLEC1
gene id: 9595:ERLEC1
uniprot id: A0A2I2YL59
uniprot id: G3QE52
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9595:FCF1
gene id: 9595:FCF1
uniprot id: G3RJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9595:POT1
gene id: 9595:POT1
uniprot id: G3RFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9595:ATPAF2
gene id: 9595:ATPAF2
uniprot id: A0A2I2Z239
uniprot id: G3QE00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9595:DPH6
gene id: 9595:DPH6
uniprot id: A0A2I2ZDW5
uniprot id: G3RHL7
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9595:LOC101127528
gene id: 9595:LOC101127528
uniprot id: G3RYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9595:RUNX1
gene id: 9595:RUNX1
uniprot id: A0A2I2YIQ6
uniprot id: A0A2I2ZU46
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9595:PLD2
gene id: 9595:PLD2
uniprot id: G3QUP6
names: Similarity
messages: Belongs to the phospholipase D family.

9595:LOC101128279
gene id: 9595:LOC101128279
uniprot id: A0A2I2ZGA3
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:FMNL1
gene id: 9595:FMNL1
uniprot id: A0A2I2YLV3
names: Similarity
messages: Belongs to the formin homology family.

9595:POU1F1
gene id: 9595:POU1F1
uniprot id: G3R8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9595:PPM1F
gene id: 9595:PPM1F
uniprot id: G3QEE2
names: Similarity
messages: Belongs to the PP2C family.

9595:GIMAP8
gene id: 9595:GIMAP8
uniprot id: G3S4T9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:SART3
gene id: 9595:SART3
uniprot id: G3R7E9
names: Subcellular Location Annotation
messages: nucleoplasm

9595:IZUMO3
gene id: 9595:IZUMO3
uniprot id: A0A2I2YUM5
uniprot id: G3R790
names: Similarity
messages: Belongs to the Izumo family.

9595:GINS4
gene id: 9595:GINS4
uniprot id: A0A2I2ZYR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9595:MC2R
gene id: 9595:MC2R
uniprot id: G3QPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

9595:PSME3
gene id: 9595:PSME3
uniprot id: A0A2I2Z4R3
uniprot id: G3R573
names: Similarity
messages: Belongs to the PA28 family.

9595:PLA2G5
gene id: 9595:PLA2G5
uniprot id: G3QVJ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:TERF2IP
gene id: 9595:TERF2IP
uniprot id: G3SE84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9595:DUSP26
gene id: 9595:DUSP26
uniprot id: G3REJ5
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9595:TRIP12
gene id: 9595:TRIP12
uniprot id: A0A2I2ZCZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9595:GPN2
gene id: 9595:GPN2
uniprot id: G3RH09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9595:DCTN6
gene id: 9595:DCTN6
uniprot id: A0A2I2YXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9595:CLDN17
gene id: 9595:CLDN17
uniprot id: G3QFD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:RPS29
gene id: 9595:RPS29
uniprot id: A0A2I2Z627
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9595:POLR2M
gene id: 9595:POLR2M
uniprot id: A0A2I2Y892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9595:LOC101152773
gene id: 9595:LOC101152773
uniprot id: G3S254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative pheromone receptor.

9595:STAC3
gene id: 9595:STAC3
uniprot id: G3R5C1
names: Subcellular Location Annotation
messages: sarcolemma

9595:TLR3
gene id: 9595:TLR3
uniprot id: G3SGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9595:TSR1
gene id: 9595:TSR1
uniprot id: G3QH58
names: Subcellular Location Annotation
messages: nucleolus

9595:EPYC
gene id: 9595:EPYC
uniprot id: G3RAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

9595:BORCS8
gene id: 9595:BORCS8
uniprot id: G3RN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9595:TNR
gene id: 9595:TNR
uniprot id: G3RJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9595:SLC9C2
gene id: 9595:SLC9C2
uniprot id: G3R4F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9595:SOAT1
gene id: 9595:SOAT1
uniprot id: G3S252
uniprot id: G3S4J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:BAMBI
gene id: 9595:BAMBI
uniprot id: G3QPL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9595:STAM
gene id: 9595:STAM
uniprot id: G3QDI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9595:PLA2G15
gene id: 9595:PLA2G15
uniprot id: G3QGS4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:PHETA2
gene id: 9595:PHETA2
uniprot id: A0A2I2YH37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9595:SYF2
gene id: 9595:SYF2
uniprot id: A0A2I2YYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9595:WASF1
gene id: 9595:WASF1
uniprot id: G3QWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:ZPBP
gene id: 9595:ZPBP
uniprot id: G3RKU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9595:HARBI1
gene id: 9595:HARBI1
uniprot id: G3QP39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9595:EDN2
gene id: 9595:EDN2
uniprot id: G3RLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9595:THYN1
gene id: 9595:THYN1
uniprot id: G3QV97
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9595:MFSD4B
gene id: 9595:MFSD4B
uniprot id: G3R0E5
names: Subcellular Location Annotation
messages: Membrane

9595:ATG12
gene id: 9595:ATG12
uniprot id: A0A2I2ZEL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9595:IL16
gene id: 9595:IL16
uniprot id: G3QR00
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9595:LYPLAL1
gene id: 9595:LYPLAL1
uniprot id: G3QHC1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9595:ICAM4
gene id: 9595:ICAM4
uniprot id: G3QT47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9595:DLL3
gene id: 9595:DLL3
uniprot id: A0A2I2ZIN7
uniprot id: G3REV8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:PLAU
gene id: 9595:PLAU
uniprot id: G3RGY4
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9595:CFC1B
gene id: 9595:CFC1B
uniprot id: G3SED3
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC109025355
gene id: 9595:LOC109025355
uniprot id: A0A2I2YDT2
names: Subcellular Location Annotation
messages: Membrane

9595:TLX1
gene id: 9595:TLX1
uniprot id: G3S1Q9
names: Subcellular Location Annotation
messages: Nucleus

9595:PPAT
gene id: 9595:PPAT
uniprot id: G3QPM3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9595:SLC7A11
gene id: 9595:SLC7A11
uniprot id: G3SDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9595:ENY2
gene id: 9595:ENY2
uniprot id: A0A2I2Y869
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9595:PCCA
gene id: 9595:PCCA
uniprot id: A0A2I2YJZ1
uniprot id: G3R9X1
names: Subcellular Location Annotation
messages: Mitochondrion matrix

9595:LYNX1
gene id: 9595:LYNX1
uniprot id: A0A2I2Z8F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CTSO
gene id: 9595:CTSO
uniprot id: G3RJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:ORMDL3
gene id: 9595:ORMDL3
uniprot id: G3QZ09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9595:FAM221B
gene id: 9595:FAM221B
uniprot id: G3R6M7
names: Similarity
messages: Belongs to the FAM221 family.

9595:CTSC
gene id: 9595:CTSC
uniprot id: G3QI81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9595:MHC-DMB
gene id: 9595:MHC-DMB
uniprot id: G3RQJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:CSTA
gene id: 9595:CSTA
uniprot id: G3S822
names: Similarity
messages: Belongs to the cystatin family.

9595:LMOD2
gene id: 9595:LMOD2
uniprot id: G3S961
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9595:LOC101124279
gene id: 9595:LOC101124279
uniprot id: G3S2N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9595:RIMKLA
gene id: 9595:RIMKLA
uniprot id: G3S078
names: Similarity
messages: Belongs to the RimK family.

9595:LOC101146463
gene id: 9595:LOC101146463
uniprot id: A0A2I2YY39
uniprot id: A0A2I2ZB38
names: Subcellular Location Annotation
messages: Cytoplasm

9595:HPSE
gene id: 9595:HPSE
uniprot id: A0A2I2ZSL7
uniprot id: G3QJZ7
uniprot id: G3RPR9
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9595:MBD4
gene id: 9595:MBD4
uniprot id: G3S7S7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

9595:DDIT3
gene id: 9595:DDIT3
uniprot id: G3QHW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9595:FAM90A1
gene id: 9595:FAM90A1
uniprot id: G3RBI7
names: Similarity
messages: Belongs to the FAM90 family.

9595:GPI
gene id: 9595:GPI
uniprot id: G3RPM0
names: Similarity
messages: Belongs to the GPI family.

9595:KCNA1
gene id: 9595:KCNA1
uniprot id: G3S108
names: Subcellular Location Annotation
messages: Membrane

9595:ZSCAN30
gene id: 9595:ZSCAN30
uniprot id: G3RWS5
names: Subcellular Location Annotation
messages: Nucleus

9595:OTC
gene id: 9595:OTC
uniprot id: G3R7S1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9595:SNAPIN
gene id: 9595:SNAPIN
uniprot id: G3QHF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9595:CD164
gene id: 9595:CD164
uniprot id: A0A2I2ZU49
uniprot id: G3QLH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:MAP3K7
gene id: 9595:MAP3K7
uniprot id: G3RXU7
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9595:PLPPR4
gene id: 9595:PLPPR4
uniprot id: G3RCC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:MPPE1
gene id: 9595:MPPE1
uniprot id: A0A2I2YXR5
uniprot id: G3QDC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9595:CPLX2
gene id: 9595:CPLX2
uniprot id: A0A2I2Y633
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:SRSF5
gene id: 9595:SRSF5
uniprot id: G3RK07
names: Similarity
messages: Belongs to the splicing factor SR family.

9595:CDC42EP3
gene id: 9595:CDC42EP3
uniprot id: A0A2I2ZB00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9595:HS3ST5
gene id: 9595:HS3ST5
uniprot id: G3QFL4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:SCFD2
gene id: 9595:SCFD2
uniprot id: G3R939
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9595:FAM124B
gene id: 9595:FAM124B
uniprot id: A0A2I2YFJ3
uniprot id: G3QFD1
names: Similarity
messages: Belongs to the FAM124 family.

9595:TRMT2B
gene id: 9595:TRMT2B
uniprot id: G3SG06
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TBX4
gene id: 9595:TBX4
uniprot id: G3RDF8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:SLC16A3
gene id: 9595:SLC16A3
uniprot id: G3QCW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9595:DCSTAMP
gene id: 9595:DCSTAMP
uniprot id: G3QHW0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC39A2
gene id: 9595:SLC39A2
uniprot id: G3RC51
names: Subcellular Location Annotation
messages: Membrane

9595:TMCO4
gene id: 9595:TMCO4
uniprot id: G3QRD2
names: Similarity
messages: Belongs to the TMCO4 family.

9595:GATA1
gene id: 9595:GATA1
uniprot id: G3RS51
names: Subcellular Location Annotation
messages: Nucleus

9595:RARA
gene id: 9595:RARA
uniprot id: A0A2I2Z5W1
uniprot id: A0A2I2ZS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:TM4SF19
gene id: 9595:TM4SF19
uniprot id: A0A2I2Y6E8
uniprot id: A0A2I2ZSE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:C6
gene id: 9595:C6
uniprot id: G3QYV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:CD14
gene id: 9595:CD14
uniprot id: G3R4C0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9595:TMEM98
gene id: 9595:TMEM98
uniprot id: G3RBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9595:SGO1
gene id: 9595:SGO1
uniprot id: G3QU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9595:POLB
gene id: 9595:POLB
uniprot id: G3SIQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9595:LOC101143886
gene id: 9595:LOC101143886
uniprot id: G3QL18
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9595:ACOX3
gene id: 9595:ACOX3
uniprot id: G3RSD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9595:ALDH5A1
gene id: 9595:ALDH5A1
uniprot id: Q6A2H1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion
messages: Redox-regulated. Inhibited under oxydizing conditions (By similarity).

9595:FAM135B
gene id: 9595:FAM135B
uniprot id: G3QWR5
names: Similarity
messages: Belongs to the FAM135 family.

9595:TAS2R1
gene id: 9595:TAS2R1
uniprot id: G3RD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:PRTFDC1
gene id: 9595:PRTFDC1
uniprot id: G3RFK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9595:SRPRA
gene id: 9595:SRPRA
uniprot id: G3RB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9595:MPL
gene id: 9595:MPL
uniprot id: A0A2I2Y7X8
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.

9595:VGLL4
gene id: 9595:VGLL4
uniprot id: A0A2I2YTG3
uniprot id: A0A2I2ZKA6
uniprot id: G3QLS5
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9595:DKC1
gene id: 9595:DKC1
uniprot id: G3RNN2
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9595:SLC5A1
gene id: 9595:SLC5A1
uniprot id: G3SHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9595:PAF1
gene id: 9595:PAF1
uniprot id: A0A2I2Z5M9
names: Similarity
messages: Belongs to the PAF1 family.

9595:ARPP19
gene id: 9595:ARPP19
uniprot id: A0A2I2Y2C8
uniprot id: A0A2I2ZT76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9595:B4GALT1
gene id: 9595:B4GALT1
uniprot id: G3R175
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:AR
gene id: 9595:AR
uniprot id: A0A2I2YGE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9595:NDUFB8
gene id: 9595:NDUFB8
uniprot id: Q0MQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:WSCD1
gene id: 9595:WSCD1
uniprot id: G3QNF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9595:WIPI2
gene id: 9595:WIPI2
uniprot id: A0A2I2Y4N6
uniprot id: G3S581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

9595:KCNJ1
gene id: 9595:KCNJ1
uniprot id: G3QQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:FAM83F
gene id: 9595:FAM83F
uniprot id: G3QVF6
names: Similarity
messages: Belongs to the FAM83 family.

9595:ART3
gene id: 9595:ART3
uniprot id: A0A2I2YM94
uniprot id: G3SFL6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9595:FTHL17
gene id: 9595:FTHL17
uniprot id: G3QY39
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9595:DNAL4
gene id: 9595:DNAL4
uniprot id: G3RCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9595:SLC7A8
gene id: 9595:SLC7A8
uniprot id: G3QWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9595:WNT10B
gene id: 9595:WNT10B
uniprot id: G3R6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:FMNL2
gene id: 9595:FMNL2
uniprot id: A0A2I2Z7A4
names: Similarity
messages: Belongs to the formin homology family.

9595:LRRC42
gene id: 9595:LRRC42
uniprot id: G3R555
names: Similarity
messages: Belongs to the LRRC42 family.

9595:ATG13
gene id: 9595:ATG13
uniprot id: A0A2I2Z9M8
uniprot id: G3QSD9
uniprot id: G3RZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9595:SPHKAP
gene id: 9595:SPHKAP
uniprot id: G3R5L9
names: Similarity
messages: Belongs to the AKAP110 family.

9595:GRIA3
gene id: 9595:GRIA3
uniprot id: G3R2A6
uniprot id: G3SEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:LIX1L
gene id: 9595:LIX1L
uniprot id: G3RMP0
names: Similarity
messages: Belongs to the LIX1 family.

9595:NOL6
gene id: 9595:NOL6
uniprot id: G3QN23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9595:SERPINH1
gene id: 9595:SERPINH1
uniprot id: G3QRM5
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9595:ADAMTS5
gene id: 9595:ADAMTS5
uniprot id: G3QVR6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:BPNT1
gene id: 9595:BPNT1
uniprot id: G3S9T6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9595:MFGE8
gene id: 9595:MFGE8
uniprot id: G3RF38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:NDUFA9
gene id: 9595:NDUFA9
uniprot id: Q0MQB3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation.
messages: Belongs to the complex I NDUFA9 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity). Interacts with CLOCK (By similarity). Interacts with RAB5IF (By similarity).
messages: Mitochondrion matrix

9595:PIGO
gene id: 9595:PIGO
uniprot id: G3QL12
uniprot id: G3S324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CDS1
gene id: 9595:CDS1
uniprot id: G3QJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9595:LRRC8A
gene id: 9595:LRRC8A
uniprot id: G3RLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:EIF2B2
gene id: 9595:EIF2B2
uniprot id: G3QE21
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9595:LOC101138548
gene id: 9595:LOC101138548
uniprot id: G3QSL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:POLR3GL
gene id: 9595:POLR3GL
uniprot id: G3R856
uniprot id: G3SHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:WAPL
gene id: 9595:WAPL
uniprot id: G3S4Q4
names: Similarity
messages: Belongs to the WAPL family.

9595:ARAP2
gene id: 9595:ARAP2
uniprot id: G3RS92
names: Subcellular Location Annotation
messages: Cytoplasm

9595:MFN1
gene id: 9595:MFN1
uniprot id: G3R1R7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:TMEM184B
gene id: 9595:TMEM184B
uniprot id: G3QVV3
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101150033
gene id: 9595:LOC101150033
uniprot id: A0A2I2ZPE1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:SCTR
gene id: 9595:SCTR
uniprot id: G3SA07
names: Subcellular Location Annotation
messages: Membrane

9595:CNTNAP5
gene id: 9595:CNTNAP5
uniprot id: G3QK85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9595:FGF1
gene id: 9595:FGF1
uniprot id: A0A2I2YI26
uniprot id: G3RPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9595:CENPC
gene id: 9595:CENPC
uniprot id: G3R2W2
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9595:TMEM131
gene id: 9595:TMEM131
uniprot id: G3QGP6
names: Similarity
messages: Belongs to the TMEM131 family.

9595:CD5L
gene id: 9595:CD5L
uniprot id: G3R058
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MMP27
gene id: 9595:MMP27
uniprot id: G3R045
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:C22H22orf39
gene id: 9595:C22H22orf39
uniprot id: A0A2I2YAN1
uniprot id: G3QNB3
names: Similarity
messages: Belongs to the UPF0545 family.

9595:WDR83OS
gene id: 9595:WDR83OS
uniprot id: G3RC27
names: Similarity
messages: Belongs to the Asterix family.

9595:XRCC5
gene id: 9595:XRCC5
uniprot id: G3R763
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9595:CCNB1
gene id: 9595:CCNB1
uniprot id: G3QGP3
names: Similarity
messages: Belongs to the cyclin family.

9595:KIT
gene id: 9595:KIT
uniprot id: G3RHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:CUL2
gene id: 9595:CUL2
uniprot id: A0A2I2YYC6
names: Similarity
messages: Belongs to the cullin family.

9595:RPS27L
gene id: 9595:RPS27L
uniprot id: G3RVW3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:PDCL3
gene id: 9595:PDCL3
uniprot id: A0A2I2YTV8
names: Similarity
messages: Belongs to the phosducin family.

9595:ZNF532
gene id: 9595:ZNF532
uniprot id: G3SAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:WNT5B
gene id: 9595:WNT5B
uniprot id: A0A2I2Z2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:UNG
gene id: 9595:UNG
uniprot id: G3RY62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

9595:LOC101136257
gene id: 9595:LOC101136257
uniprot id: G3SHJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:MTCP1
gene id: 9595:MTCP1
uniprot id: A0A2I2ZHP0
names: Similarity
messages: Belongs to the TCL1 family.

9595:POLR3B
gene id: 9595:POLR3B
uniprot id: A0A2I2Z996
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9595:KIF5B
gene id: 9595:KIF5B
uniprot id: G3RC75
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:DNAH3
gene id: 9595:DNAH3
uniprot id: G3SKH6
names: Similarity
messages: Belongs to the dynein heavy chain family.

9595:LOC101132254
gene id: 9595:LOC101132254
uniprot id: G3QQW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CMKLR1
gene id: 9595:CMKLR1
uniprot id: G3R3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9595:HCRTR2
gene id: 9595:HCRTR2
uniprot id: G3SII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SCNN1A
gene id: 9595:SCNN1A
uniprot id: G3R5I8
names: Subcellular Location Annotation
messages: Membrane

9595:MSMP
gene id: 9595:MSMP
uniprot id: G3QWQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9595:HGS
gene id: 9595:HGS
uniprot id: G3R1Q6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9595:LOC101145461
gene id: 9595:LOC101145461
uniprot id: G3RIY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9595:PSMB6
gene id: 9595:PSMB6
uniprot id: G3R756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:EIF4A3
gene id: 9595:EIF4A3
uniprot id: G3RAX3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:ADAMTS14
gene id: 9595:ADAMTS14
uniprot id: G3R9J1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:DTD2
gene id: 9595:DTD2
uniprot id: A0A2I2YZI5
names: Similarity
messages: Belongs to the DTD family.

9595:PRLR
gene id: 9595:PRLR
uniprot id: A0A2I2YN87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9595:SPATA18
gene id: 9595:SPATA18
uniprot id: A0A2I2ZD49
uniprot id: G3QZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9595:GTPBP8
gene id: 9595:GTPBP8
uniprot id: G3RSD1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9595:ANXA7
gene id: 9595:ANXA7
uniprot id: A0A2I2ZQ69
uniprot id: G3QP82
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:CD247
gene id: 9595:CD247
uniprot id: G3RQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9595:GPC1
gene id: 9595:GPC1
uniprot id: A0A2I2Y6K0
uniprot id: G3QGJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

9595:KCNS1
gene id: 9595:KCNS1
uniprot id: A0A2I2YND0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CENPT
gene id: 9595:CENPT
uniprot id: G3QGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9595:KHDRBS2
gene id: 9595:KHDRBS2
uniprot id: G3SH19
names: Similarity
messages: Belongs to the KHDRBS family.

9595:ASB13
gene id: 9595:ASB13
uniprot id: G3QDY4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:RBP7
gene id: 9595:RBP7
uniprot id: G3RS30
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:DARS2
gene id: 9595:DARS2
uniprot id: G3RQA7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9595:PDE4D
gene id: 9595:PDE4D
uniprot id: A0A2I2YCR8
uniprot id: A0A2I2ZRN8
uniprot id: G3QVP9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:DMTF1
gene id: 9595:DMTF1
uniprot id: G3QJY1
names: Subcellular Location Annotation
messages: Nucleus

9595:NRP2
gene id: 9595:NRP2
uniprot id: A0A2I2YSW1
uniprot id: G3R279
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TEKT3
gene id: 9595:TEKT3
uniprot id: G3QKW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9595:SPEM1
gene id: 9595:SPEM1
uniprot id: G3R818
names: Subcellular Location Annotation
messages: Membrane

9595:HMGB1
gene id: 9595:HMGB1
uniprot id: G3SGE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

9595:GIMAP4
gene id: 9595:GIMAP4
uniprot id: G3QIU6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:CERT1
gene id: 9595:CERT1
uniprot id: G3QQS6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9595:LOC101143299
gene id: 9595:LOC101143299
uniprot id: G3R7E3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:IGF2R
gene id: 9595:IGF2R
uniprot id: G3QH23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ERCC1
gene id: 9595:ERCC1
uniprot id: A0A2I2YAK9
uniprot id: A0A2I2YPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9595:FXYD3
gene id: 9595:FXYD3
uniprot id: G3S0U8
uniprot id: G3SIJ8
names: Caution
names: Similarity
messages: Belongs to the FXYD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AQP11
gene id: 9595:AQP11
uniprot id: G3R8H6
names: Subcellular Location Annotation
messages: Membrane

9595:AMELX
gene id: 9595:AMELX
uniprot id: A0A2I2Y2N2
uniprot id: A0A2I2YUA7
uniprot id: G3SDK0
names: Similarity
messages: Belongs to the amelogenin family.

9595:UTP15
gene id: 9595:UTP15
uniprot id: A0A2I2ZXL7
names: Subcellular Location Annotation
messages: nucleolus

9595:LOC101124358
gene id: 9595:LOC101124358
uniprot id: G3SI34
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:PLAC8L1
gene id: 9595:PLAC8L1
uniprot id: G3QYX5
names: Similarity
messages: Belongs to the cornifelin family.

9595:PRMT7
gene id: 9595:PRMT7
uniprot id: G3QGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9595:OS9
gene id: 9595:OS9
uniprot id: A0A2I2ZSU4
uniprot id: G3QGC5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9595:LOC101123911
gene id: 9595:LOC101123911
uniprot id: G3RNK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:TAS2R3
gene id: 9595:TAS2R3
uniprot id: Q645Y5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9595:AK6
gene id: 9595:AK6
uniprot id: G3RHN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9595:SF3B3
gene id: 9595:SF3B3
uniprot id: G3QL55
names: Subcellular Location Annotation
messages: Nucleus

9595:IFNGR1
gene id: 9595:IFNGR1
uniprot id: G3QZK7
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9595:CBX6
gene id: 9595:CBX6
uniprot id: A0A2I2Y460
names: Subcellular Location Annotation
messages: Nucleus

9595:WDFY2
gene id: 9595:WDFY2
uniprot id: G3S422
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9595:DGAT2L6
gene id: 9595:DGAT2L6
uniprot id: G3QG27
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ANXA11
gene id: 9595:ANXA11
uniprot id: G3QST6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:DAZAP2
gene id: 9595:DAZAP2
uniprot id: G3RU69
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9595:GPR155
gene id: 9595:GPR155
uniprot id: G3SBT6
names: Subcellular Location Annotation
messages: Membrane

9595:DYNC1I1
gene id: 9595:DYNC1I1
uniprot id: A0A2I2Y567
uniprot id: G3QDB5
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9595:PRPSAP1
gene id: 9595:PRPSAP1
uniprot id: G3SKM1
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9595:SLC17A2
gene id: 9595:SLC17A2
uniprot id: A0A2I2ZWL3
uniprot id: G3R8V3
names: Subcellular Location Annotation
messages: Membrane

9595:QRSL1
gene id: 9595:QRSL1
uniprot id: G3SBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9595:EGR3
gene id: 9595:EGR3
uniprot id: G3QJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9595:LOC101135475
gene id: 9595:LOC101135475
uniprot id: G3R9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRH
gene id: 9595:TRH
uniprot id: A0A2I2YDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9595:CIAO2A
gene id: 9595:CIAO2A
uniprot id: A0A2I2YYL6
uniprot id: G3RK86
names: Similarity
messages: Belongs to the MIP18 family.

9595:MRPL44
gene id: 9595:MRPL44
uniprot id: G3RE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9595:GPRC6A
gene id: 9595:GPRC6A
uniprot id: A0A2I2ZEV7
uniprot id: G3QFV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:KCNU1
gene id: 9595:KCNU1
uniprot id: G3R7C6
names: Subcellular Location Annotation
messages: Membrane

9595:ASB4
gene id: 9595:ASB4
uniprot id: G3QUG4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:MED29
gene id: 9595:MED29
uniprot id: G3QHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9595:LOC101129299
gene id: 9595:LOC101129299
uniprot id: G3RVC1
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9595:ALKBH8
gene id: 9595:ALKBH8
uniprot id: G3RHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9595:RPL30
gene id: 9595:RPL30
uniprot id: G3QRX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9595:SLC26A4
gene id: 9595:SLC26A4
uniprot id: G3SKH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9595:GCM1
gene id: 9595:GCM1
uniprot id: G3QUI3
names: Subcellular Location Annotation
messages: Nucleus

9595:EPC1
gene id: 9595:EPC1
uniprot id: A0A2I2YFP3
uniprot id: G3QYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9595:SUSD1
gene id: 9595:SUSD1
uniprot id: A0A2I2Z786
uniprot id: G3RA61
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AZIN2
gene id: 9595:AZIN2
uniprot id: G3RFZ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9595:GABRR3
gene id: 9595:GABRR3
uniprot id: G3R834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:INHBC
gene id: 9595:INHBC
uniprot id: G3S8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:SSBP1
gene id: 9595:SSBP1
uniprot id: G3R2E1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9595:SERINC4
gene id: 9595:SERINC4
uniprot id: G3RFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:PIM2
gene id: 9595:PIM2
uniprot id: G3R726
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9595:GAL3ST1
gene id: 9595:GAL3ST1
uniprot id: G3R2Y3
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9595:LOC101152713
gene id: 9595:LOC101152713
uniprot id: G3QM76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FARS2
gene id: 9595:FARS2
uniprot id: G3R851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9595:JUNB
gene id: 9595:JUNB
uniprot id: A0A2I2ZDY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9595:NRG3
gene id: 9595:NRG3
uniprot id: A0A2I2ZMU8
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SMC1B
gene id: 9595:SMC1B
uniprot id: A0A2I2ZA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9595:CCDC47
gene id: 9595:CCDC47
uniprot id: G3RR28
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9595:GSG1L2
gene id: 9595:GSG1L2
uniprot id: G3QZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9595:CARTPT
gene id: 9595:CARTPT
uniprot id: G3QQC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9595:ABHD2
gene id: 9595:ABHD2
uniprot id: G3R7Q2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9595:SMAD7
gene id: 9595:SMAD7
uniprot id: G3R4S9
names: Subcellular Location Annotation
messages: Nucleus

9595:NPVF
gene id: 9595:NPVF
uniprot id: G3R8I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9595:ABLIM3
gene id: 9595:ABLIM3
uniprot id: G3QRM3
names: Subcellular Location Annotation
messages: Cytoplasm

9595:WT1
gene id: 9595:WT1
uniprot id: G3RQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9595:LAPTM5
gene id: 9595:LAPTM5
uniprot id: G3RLG7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9595:HOXA6
gene id: 9595:HOXA6
uniprot id: G3QIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:ATP2C1
gene id: 9595:ATP2C1
uniprot id: A0A2I2ZCG7
uniprot id: A0A2I2ZE06
uniprot id: G3S1X4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9595:MMD
gene id: 9595:MMD
uniprot id: G3SKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:FGA
gene id: 9595:FGA
uniprot id: G3RWD8
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9595:OLFM3
gene id: 9595:OLFM3
uniprot id: A0A2I2YBG7
uniprot id: G3RLQ0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9595:OSBPL1A
gene id: 9595:OSBPL1A
uniprot id: G3QTD4
uniprot id: G3SJJ5
names: Similarity
messages: Belongs to the OSBP family.

9595:TOP1MT
gene id: 9595:TOP1MT
uniprot id: A0A2I2Y7X3
uniprot id: G3R1M7
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9595:GUCA2A
gene id: 9595:GUCA2A
uniprot id: G3R796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9595:SLC16A10
gene id: 9595:SLC16A10
uniprot id: G3R8F1
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101135660
gene id: 9595:LOC101135660
uniprot id: G3QJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CD1A
gene id: 9595:CD1A
uniprot id: G3S7N6
names: Similarity
messages: Belongs to the MHC class I family.

9595:ALDH6A1
gene id: 9595:ALDH6A1
uniprot id: G3R112
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9595:RETN
gene id: 9595:RETN
uniprot id: G3R281
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9595:MARS1
gene id: 9595:MARS1
uniprot id: G3QHW7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:NUDT7
gene id: 9595:NUDT7
uniprot id: A0A2I2YL84
uniprot id: G3RLI6
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9595:REEP4
gene id: 9595:REEP4
uniprot id: A0A2I2ZFL5
uniprot id: A0A2I2ZJP1
uniprot id: G3QPB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DBX1
gene id: 9595:DBX1
uniprot id: G3RFV5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101132438
gene id: 9595:LOC101132438
uniprot id: G3QMI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9595:EZR
gene id: 9595:EZR
uniprot id: G3RBW2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:TMOD4
gene id: 9595:TMOD4
uniprot id: G3S261
names: Subcellular Location Annotation
messages: cytoskeleton

9595:TMEM200A
gene id: 9595:TMEM200A
uniprot id: G3RBN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9595:PDE1C
gene id: 9595:PDE1C
uniprot id: A0A2I2YMV7
uniprot id: A0A2I2ZTC6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:KEG83 p11
gene id: 9595:KEG83_p11
uniprot id: G3SHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9595:FSCN1
gene id: 9595:FSCN1
uniprot id: G3RSQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9595:TOP3A
gene id: 9595:TOP3A
uniprot id: G3QKQ6
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9595:TOX4
gene id: 9595:TOX4
uniprot id: G3RFD2
names: Subcellular Location Annotation
messages: Nucleus

9595:CMC4
gene id: 9595:CMC4
uniprot id: G3R7A8
names: Similarity
messages: Belongs to the CMC4 family.

9595:VANGL2
gene id: 9595:VANGL2
uniprot id: G3RDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9595:KCNK16
gene id: 9595:KCNK16
uniprot id: G3QXC1
uniprot id: G3SGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:F13A1
gene id: 9595:F13A1
uniprot id: G3QFU9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:NCAPD3
gene id: 9595:NCAPD3
uniprot id: G3QV81
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9595:POFUT1
gene id: 9595:POFUT1
uniprot id: A0A2I2ZRQ2
uniprot id: G3RAS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9595:NKAIN1
gene id: 9595:NKAIN1
uniprot id: G3RV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9595:RAD21
gene id: 9595:RAD21
uniprot id: G3R826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9595:GPR35
gene id: 9595:GPR35
uniprot id: G3SHK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:ABCD1
gene id: 9595:ABCD1
uniprot id: G3QS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9595:SIKE1
gene id: 9595:SIKE1
uniprot id: G3RHY2
names: Similarity
messages: Belongs to the SIKE family.

9595:MMACHC
gene id: 9595:MMACHC
uniprot id: G3QRN2
names: Similarity
messages: Belongs to the MMACHC family.

9595:B3GNT4
gene id: 9595:B3GNT4
uniprot id: G3RLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:RITA1
gene id: 9595:RITA1
uniprot id: G3R4H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9595:YRDC
gene id: 9595:YRDC
uniprot id: G3QXB2
names: Similarity
messages: Belongs to the SUA5 family.

9595:FARSA
gene id: 9595:FARSA
uniprot id: G3QLK6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9595:VAT1
gene id: 9595:VAT1
uniprot id: G3RZ64
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9595:RRAGB
gene id: 9595:RRAGB
uniprot id: G3R786
uniprot id: G3S8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:TRIM71
gene id: 9595:TRIM71
uniprot id: G3RLQ5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9595:CASS4
gene id: 9595:CASS4
uniprot id: G3QNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9595:DDX1
gene id: 9595:DDX1
uniprot id: G3R9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

9595:ASB5
gene id: 9595:ASB5
uniprot id: A0A2I2Z2E6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:LOC101141204
gene id: 9595:LOC101141204
uniprot id: G3QMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TDRD5
gene id: 9595:TDRD5
uniprot id: G3R6R4
uniprot id: G3S9Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9595:ADAM33
gene id: 9595:ADAM33
uniprot id: G3RLB2
uniprot id: G3RSF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:THUMPD2
gene id: 9595:THUMPD2
uniprot id: G3SK58
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9595:SENP3
gene id: 9595:SENP3
uniprot id: G3R7B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9595:PTGFR
gene id: 9595:PTGFR
uniprot id: A0A2I2ZE29
uniprot id: G3REY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CCT2
gene id: 9595:CCT2
uniprot id: A0A2I2ZL99
uniprot id: G3QTT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:PDK2
gene id: 9595:PDK2
uniprot id: G3RHS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:LOC101143367
gene id: 9595:LOC101143367
uniprot id: G3RP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:TAF8
gene id: 9595:TAF8
uniprot id: G3R7F5
uniprot id: G3SHE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9595:ZKSCAN5
gene id: 9595:ZKSCAN5
uniprot id: G3R289
names: Subcellular Location Annotation
messages: Nucleus

9595:NUP210
gene id: 9595:NUP210
uniprot id: G3RNJ2
names: Similarity
messages: Belongs to the NUP210 family.

9595:CR2
gene id: 9595:CR2
uniprot id: A0A2I2Y6U3
uniprot id: A0A2I2ZFG4
uniprot id: G3QLP1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:DLX5
gene id: 9595:DLX5
uniprot id: G3QP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:PLOD3
gene id: 9595:PLOD3
uniprot id: G3RN67
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9595:DMRTC2
gene id: 9595:DMRTC2
uniprot id: A0A2I2ZSU6
uniprot id: G3S9N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:IL20
gene id: 9595:IL20
uniprot id: A0A2I2Y6H9
uniprot id: G3RBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:NRXN2
gene id: 9595:NRXN2
uniprot id: A0A2I2Y2T6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ADAMTS4
gene id: 9595:ADAMTS4
uniprot id: G3QXK7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:LOC101137485
gene id: 9595:LOC101137485
uniprot id: G3R8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9595:EPHB3
gene id: 9595:EPHB3
uniprot id: G3RJK3
names: Subcellular Location Annotation
messages: Membrane

9595:MTHFR
gene id: 9595:MTHFR
uniprot id: A0A2I2Y6Y9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9595:ALG13
gene id: 9595:ALG13
uniprot id: A0A2I2YN31
uniprot id: A0A2I2ZS30
uniprot id: G3R4F8
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9595:PFN3
gene id: 9595:PFN3
uniprot id: G3R2G5
names: Similarity
messages: Belongs to the profilin family.

9595:BCAR1
gene id: 9595:BCAR1
uniprot id: A0A2I2YVQ0
uniprot id: G3R533
uniprot id: G3RT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9595:MC4R
gene id: 9595:MC4R
uniprot id: G3RGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9595:TNNT3
gene id: 9595:TNNT3
uniprot id: A0A2I2YEV9
uniprot id: A0A2I2YJ48
uniprot id: G3QNF0
uniprot id: G3SI23
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9595:CPEB3
gene id: 9595:CPEB3
uniprot id: A0A2I2ZU18
names: Similarity
messages: Belongs to the RRM CPEB family.

9595:PC
gene id: 9595:PC
uniprot id: G3REY4
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9595:TBPL2
gene id: 9595:TBPL2
uniprot id: G3QFG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9595:PRAF2
gene id: 9595:PRAF2
uniprot id: G3QE86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9595:TINAG
gene id: 9595:TINAG
uniprot id: G3QIW0
names: Similarity
messages: Belongs to the peptidase C1 family.

9595:SLFN11
gene id: 9595:SLFN11
uniprot id: G3SKH2
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9595:PAN2
gene id: 9595:PAN2
uniprot id: A0A2I2ZVV6
uniprot id: G3R165
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9595:PRRX2
gene id: 9595:PRRX2
uniprot id: G3QE99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9595:ZFP36
gene id: 9595:ZFP36
uniprot id: G3REP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9595:C8H8orf37
gene id: 9595:C8H8orf37
uniprot id: G3QXT9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9595:KDR
gene id: 9595:KDR
uniprot id: G3RAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:SFXN1
gene id: 9595:SFXN1
uniprot id: G3QYR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9595:OOSP2
gene id: 9595:OOSP2
uniprot id: G3RV37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9595:ST3GAL6
gene id: 9595:ST3GAL6
uniprot id: G3RLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:LZTFL1
gene id: 9595:LZTFL1
uniprot id: A0A2I2YVN9
uniprot id: G3QI68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9595:B4GALT6
gene id: 9595:B4GALT6
uniprot id: G3QLQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:TOR4A
gene id: 9595:TOR4A
uniprot id: A0A2I2ZKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

9595:LOC101149265
gene id: 9595:LOC101149265
uniprot id: A0A2I2ZXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9595:NME5
gene id: 9595:NME5
uniprot id: G3QVZ0
names: Similarity
messages: Belongs to the NDK family.

9595:KCNJ4
gene id: 9595:KCNJ4
uniprot id: G3QE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:HNRNPDL
gene id: 9595:HNRNPDL
uniprot id: G3QMB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:MMP19
gene id: 9595:MMP19
uniprot id: G3RBP6
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:PEBP1
gene id: 9595:PEBP1
uniprot id: G3RBU0
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9595:PNMA2
gene id: 9595:PNMA2
uniprot id: A0A2I2YI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9595:CD55
gene id: 9595:CD55
uniprot id: G3RY41
uniprot id: G3S1S0
uniprot id: G3SJV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:USP48
gene id: 9595:USP48
uniprot id: G3RU24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9595:ZCCHC4
gene id: 9595:ZCCHC4
uniprot id: G3S195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9595:TRAPPC2
gene id: 9595:TRAPPC2
uniprot id: G3QMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9595:MAB21L1
gene id: 9595:MAB21L1
uniprot id: G3R7X7
names: Similarity
messages: Belongs to the mab-21 family.

9595:COQ7
gene id: 9595:COQ7
uniprot id: A0A2I2YCU9
uniprot id: G3QJN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9595:TRMT112
gene id: 9595:TRMT112
uniprot id: G3QG66
names: Similarity
messages: Belongs to the TRM112 family.

9595:LOC101130814
gene id: 9595:LOC101130814
uniprot id: G3RRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MCUR1
gene id: 9595:MCUR1
uniprot id: G3QJJ7
names: Similarity
messages: Belongs to the CCDC90 family.

9595:KLHL36
gene id: 9595:KLHL36
uniprot id: A0A2I2YKJ8
names: Function
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9595:TNKS2
gene id: 9595:TNKS2
uniprot id: G3R2V0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:POLR3F
gene id: 9595:POLR3F
uniprot id: G3R7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:LOC101136823
gene id: 9595:LOC101136823
uniprot id: G3RP05
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9595:FAM162B
gene id: 9595:FAM162B
uniprot id: G3QI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9595:TPH1
gene id: 9595:TPH1
uniprot id: G3RMB3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9595:MESD
gene id: 9595:MESD
uniprot id: G3SH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9595:CCDC130
gene id: 9595:CCDC130
uniprot id: G3QUS3
names: Similarity
messages: Belongs to the CWC16 family.

9595:CIAO1
gene id: 9595:CIAO1
uniprot id: A0A2I2ZVX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9595:DDX50
gene id: 9595:DDX50
uniprot id: G3RT42
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9595:LTB4R2
gene id: 9595:LTB4R2
uniprot id: A0A2I2YAB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SAP30
gene id: 9595:SAP30
uniprot id: G3QQV4
names: Similarity
messages: Belongs to the SAP30 family.

9595:USP15
gene id: 9595:USP15
uniprot id: A0A2I2Y6G1
uniprot id: A0A2I2ZAZ8
uniprot id: G3QJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9595:USP2
gene id: 9595:USP2
uniprot id: G3QQW0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:ELOA
gene id: 9595:ELOA
uniprot id: G3RGB1
names: Subcellular Location Annotation
messages: Nucleus

9595:PPP1R9B
gene id: 9595:PPP1R9B
uniprot id: A0A2I2YAH8
names: Subcellular Location Annotation
messages: cytoskeleton

9595:BMP8A
gene id: 9595:BMP8A
uniprot id: G3RIA7
names: Similarity
messages: Belongs to the TGF-beta family.

9595:JRK
gene id: 9595:JRK
uniprot id: G3RQN3
names: Subcellular Location Annotation
messages: Nucleus

9595:NIPAL2
gene id: 9595:NIPAL2
uniprot id: G3QIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9595:DDX43
gene id: 9595:DDX43
uniprot id: G3S041
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:ADORA1
gene id: 9595:ADORA1
uniprot id: G3R347
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9595:AATF
gene id: 9595:AATF
uniprot id: G3SD86
names: Similarity
messages: Belongs to the AATF family.

9595:SMOC1
gene id: 9595:SMOC1
uniprot id: G3S8N9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TPT1
gene id: 9595:TPT1
uniprot id: G3RPB3
names: Similarity
messages: Belongs to the TCTP family.

9595:ADAM18
gene id: 9595:ADAM18
uniprot id: A0A2I2Z622
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ISCU
gene id: 9595:ISCU
uniprot id: A0A2I2YMS8
uniprot id: A0A2I2ZBF6
uniprot id: G3R7F6
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9595:LOC101147767
gene id: 9595:LOC101147767
uniprot id: G3SIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NPPA
gene id: 9595:NPPA
uniprot id: G3RAZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9595:HGF
gene id: 9595:HGF
uniprot id: G3QLL7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9595:PRPF38B
gene id: 9595:PRPF38B
uniprot id: G3R6P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9595:RPL39L
gene id: 9595:RPL39L
uniprot id: A0A2I2YLB6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9595:ZNF174
gene id: 9595:ZNF174
uniprot id: A0A2I2Y8Q0
uniprot id: G3RJY5
names: Subcellular Location Annotation
messages: Nucleus

9595:PRDM10
gene id: 9595:PRDM10
uniprot id: G3RH72
uniprot id: G3SEU8
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:EIF4E3
gene id: 9595:EIF4E3
uniprot id: A0A2I2Z4K7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9595:SNAP91
gene id: 9595:SNAP91
uniprot id: G3SJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9595:MYH2
gene id: 9595:MYH2
uniprot id: G3RN81
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:TCN2
gene id: 9595:TCN2
uniprot id: G3QD18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9595:CHAC1
gene id: 9595:CHAC1
uniprot id: G3SI09
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9595:MIOS
gene id: 9595:MIOS
uniprot id: G3QEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9595:HES7
gene id: 9595:HES7
uniprot id: G3QSJ8
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

9595:HSD17B13
gene id: 9595:HSD17B13
uniprot id: G3QKD0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:BTG3
gene id: 9595:BTG3
uniprot id: G3S0B1
names: Similarity
messages: Belongs to the BTG family.

9595:ENTPD1
gene id: 9595:ENTPD1
uniprot id: A0A2I2ZQ76
uniprot id: G3QRI2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:SNCB
gene id: 9595:SNCB
uniprot id: G3RIF1
names: Similarity
messages: Belongs to the synuclein family.

9595:SLC2A3
gene id: 9595:SLC2A3
uniprot id: A0A2I2ZMF8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9595:FCER1G
gene id: 9595:FCER1G
uniprot id: A0A2I2YN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9595:POSTN
gene id: 9595:POSTN
uniprot id: A0A2I2YTD4
uniprot id: A0A2I2YVT8
uniprot id: A0A2I2ZP34
uniprot id: G3QUZ5
names: Subcellular Location Annotation
messages: extracellular matrix

9595:KRT17
gene id: 9595:KRT17
uniprot id: G3RAM5
names: Similarity
messages: Belongs to the intermediate filament family.

9595:SLC8B1
gene id: 9595:SLC8B1
uniprot id: A0A2I2Z1H8
names: Subcellular Location Annotation
messages: Membrane

9595:OCM
gene id: 9595:OCM
uniprot id: G3S7G3
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9595:NPY1R
gene id: 9595:NPY1R
uniprot id: G3QP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:EIF5A2
gene id: 9595:EIF5A2
uniprot id: A0A2I2YC22
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9595:STK32A
gene id: 9595:STK32A
uniprot id: A0A2I2YKE0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SLC25A53
gene id: 9595:SLC25A53
uniprot id: G3RJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:CFAP36
gene id: 9595:CFAP36
uniprot id: G3QJP5
names: Similarity
messages: Belongs to the CFAP36 family.

9595:XPO4
gene id: 9595:XPO4
uniprot id: G3QF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9595:MEA1
gene id: 9595:MEA1
uniprot id: A0A2I2YBP6
uniprot id: G3QWF2
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9595:PSMD2
gene id: 9595:PSMD2
uniprot id: G3S503
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9595:SIM1
gene id: 9595:SIM1
uniprot id: G3RLN9
names: Subcellular Location Annotation
messages: Nucleus

9595:IL3
gene id: 9595:IL3
uniprot id: G3QFG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

9595:PCSK1
gene id: 9595:PCSK1
uniprot id: G3QVR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9595:MRGPRX4
gene id: 9595:MRGPRX4
uniprot id: G3RK72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9595:RBPJ
gene id: 9595:RBPJ
uniprot id: A0A2I2YWD2
uniprot id: A0A2I2Z7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9595:MAP3K13
gene id: 9595:MAP3K13
uniprot id: G3RB11
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9595:MRPL37
gene id: 9595:MRPL37
uniprot id: G3R4P7
names: Subcellular Location Annotation
messages: Mitochondrion

9595:ATIC
gene id: 9595:ATIC
uniprot id: G3QY24
names: Similarity
messages: Belongs to the PurH family.

9595:NIM1K
gene id: 9595:NIM1K
uniprot id: G3QFP4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:NAGPA
gene id: 9595:NAGPA
uniprot id: G3QQ81
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:DNASE1L3
gene id: 9595:DNASE1L3
uniprot id: A0A2I2YL99
uniprot id: G3R3K2
names: Similarity
messages: Belongs to the DNase I family.

9595:FYN
gene id: 9595:FYN
uniprot id: G3QYF5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:NTRK1
gene id: 9595:NTRK1
uniprot id: A0A2I2YZ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9595:PGLYRP1
gene id: 9595:PGLYRP1
uniprot id: G3R6A3
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9595:DMAC2L
gene id: 9595:DMAC2L
uniprot id: A0A2I2ZUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9595:NCF2
gene id: 9595:NCF2
uniprot id: G3QFC9
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9595:CMTM6
gene id: 9595:CMTM6
uniprot id: A0A2I2YZ97
names: Subcellular Location Annotation
messages: Membrane

9595:MEP1A
gene id: 9595:MEP1A
uniprot id: G3SHG1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ADSS1
gene id: 9595:ADSS1
uniprot id: G3SA31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9595:MRPL3
gene id: 9595:MRPL3
uniprot id: G3SD27
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9595:MCEE
gene id: 9595:MCEE
uniprot id: G3RZF8
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9595:CPSF4L
gene id: 9595:CPSF4L
uniprot id: G3SJG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9595:ACAD9
gene id: 9595:ACAD9
uniprot id: G3R2D4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:PTPN12
gene id: 9595:PTPN12
uniprot id: G3SHJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9595:LAMTOR2
gene id: 9595:LAMTOR2
uniprot id: A0A2I2Z8G4
uniprot id: G3QVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9595:FRAS1
gene id: 9595:FRAS1
uniprot id: G3QKZ2
names: Similarity
messages: Belongs to the FRAS1 family.

9595:TIE1
gene id: 9595:TIE1
uniprot id: G3R075
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:EP300
gene id: 9595:EP300
uniprot id: G3QYU0
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SPARCL1
gene id: 9595:SPARCL1
uniprot id: G3RHD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9595:L3HYPDH
gene id: 9595:L3HYPDH
uniprot id: G3QJ41
names: Similarity
messages: Belongs to the proline racemase family.

9595:CEBPE
gene id: 9595:CEBPE
uniprot id: G3QWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9595:ITPA
gene id: 9595:ITPA
uniprot id: G3R067
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9595:DIP2A
gene id: 9595:DIP2A
uniprot id: A0A2I2YJC3
names: Similarity
messages: Belongs to the DIP2 family.

9595:DYNLRB2
gene id: 9595:DYNLRB2
uniprot id: A0A2I2ZFJ8
uniprot id: G3R016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9595:KIF3C
gene id: 9595:KIF3C
uniprot id: G3QYI7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:PVALB
gene id: 9595:PVALB
uniprot id: G3RTP2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9595:UBN2
gene id: 9595:UBN2
uniprot id: G3QPE0
names: Similarity
messages: Belongs to the ubinuclein family.

9595:CTSH
gene id: 9595:CTSH
uniprot id: G3R9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:RNH1
gene id: 9595:RNH1
uniprot id: G3S632
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9595:EFNB1
gene id: 9595:EFNB1
uniprot id: G3R3A6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CRCP
gene id: 9595:CRCP
uniprot id: A0A2I2YVB3
uniprot id: A0A2I2ZC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9595:LOC101129167
gene id: 9595:LOC101129167
uniprot id: G3SG93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:ALG9
gene id: 9595:ALG9
uniprot id: G3QE41
uniprot id: G3R3P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ALDH1A3
gene id: 9595:ALDH1A3
uniprot id: G3QCV7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:WNT8B
gene id: 9595:WNT8B
uniprot id: G3RFB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:LOC101152878
gene id: 9595:LOC101152878
uniprot id: A0A2I2ZL90
uniprot id: G3QEF9
uniprot id: G3QVV6
uniprot id: G3QYW5
uniprot id: G3S177
uniprot id: G3SIP1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9595:CDKL4
gene id: 9595:CDKL4
uniprot id: G3R2M3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SV2A
gene id: 9595:SV2A
uniprot id: G3QKD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9595:DLGAP1
gene id: 9595:DLGAP1
uniprot id: A0A2I2YGA1
uniprot id: A0A2I2YVL4
uniprot id: A0A2I2ZKN2
uniprot id: G3SKG4
names: Similarity
messages: Belongs to the SAPAP family.

9595:TRPT1
gene id: 9595:TRPT1
uniprot id: G3S681
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9595:GRAMD1C
gene id: 9595:GRAMD1C
uniprot id: G3R234
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:DYDC2
gene id: 9595:DYDC2
uniprot id: A0A2I2ZUC6
uniprot id: G3QMF0
names: Similarity
messages: Belongs to the dpy-30 family.

9595:MED9
gene id: 9595:MED9
uniprot id: G3R6K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:RRM1
gene id: 9595:RRM1
uniprot id: G3S601
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9595:MTERF4
gene id: 9595:MTERF4
uniprot id: A0A2I2YFF2
names: Similarity
messages: Belongs to the mTERF family.

9595:APOA4
gene id: 9595:APOA4
uniprot id: G3S2R4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9595:SNX4
gene id: 9595:SNX4
uniprot id: A0A2I2YW17
names: Similarity
messages: Belongs to the sorting nexin family.

9595:LOC101131106
gene id: 9595:LOC101131106
uniprot id: Q69BK4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7) (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly. Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). Subunit 9 corresponds to the mitochondrial targeting sequence (MTS) of Rieske protein UQCRFS1. It is retained after processing and incorporated inside complex III, where it remains bound to the complex and localizes between the 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).
messages: Mitochondrion inner membrane
messages: Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix-processing peptidase (MPP) activity of the 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, which are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively. The action of the protease is also necessary for the clearance of the UQCRFS1 fragments.
messages: Several peptides are generated during UQCRFS1 insertion. According to some authors, the identification of the transit peptide as the subunit 9, does not necessary imply that it must be considered as a structural subunit of the complex III dimer as additional fragments from UQCRFS1 are also present.
messages: The Rieske protein is a high potential 2Fe-2S protein.

9595:NCAN
gene id: 9595:NCAN
uniprot id: G3QKF4
names: Caution
names: Similarity
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LAMB4
gene id: 9595:LAMB4
uniprot id: A0A2I2YHY8
uniprot id: G3RKT7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:MS4A6A
gene id: 9595:MS4A6A
uniprot id: A0A2I2YXU6
uniprot id: G3RGN9
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

9595:ITIH2
gene id: 9595:ITIH2
uniprot id: G3R8I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9595:RAB38
gene id: 9595:RAB38
uniprot id: G3RZI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9595:XRCC1
gene id: 9595:XRCC1
uniprot id: A0A2I2Y8B4
names: Subcellular Location Annotation
messages: Nucleus

9595:TF
gene id: 9595:TF
uniprot id: G3R4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9595:DDX21
gene id: 9595:DDX21
uniprot id: G3QQU4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9595:ADGRF2
gene id: 9595:ADGRF2
uniprot id: A0A2I2YJQ5
uniprot id: G3QMJ9
names: Subcellular Location Annotation
messages: Membrane

9595:TBCC
gene id: 9595:TBCC
uniprot id: G3QSX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9595:TAC3
gene id: 9595:TAC3
uniprot id: G3RGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9595:LOC101140733
gene id: 9595:LOC101140733
uniprot id: A0A2I2YTF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PRIMPOL
gene id: 9595:PRIMPOL
uniprot id: G3R887
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9595:UMOD
gene id: 9595:UMOD
uniprot id: G3SGQ4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9595:ACADS
gene id: 9595:ACADS
uniprot id: A0A2I2Z339
uniprot id: G3QI49
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:WFDC5
gene id: 9595:WFDC5
uniprot id: A4K2R4
names: Function
names: Subcellular Location Annotation
messages: Putative acid-stable proteinase inhibitor.
messages: Secreted

9595:GBE1
gene id: 9595:GBE1
uniprot id: G3SDH8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9595:PRKN
gene id: 9595:PRKN
uniprot id: A0A2I2YTU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9595:FXR1
gene id: 9595:FXR1
uniprot id: G3SF62
names: Similarity
messages: Belongs to the FMR1 family.

9595:TAS2R39
gene id: 9595:TAS2R39
uniprot id: G3RZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:BMPR1A
gene id: 9595:BMPR1A
uniprot id: G3QMC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9595:ZNF280A
gene id: 9595:ZNF280A
uniprot id: G3S5R8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9595:DPT
gene id: 9595:DPT
uniprot id: G3QLX5
names: Similarity
messages: Belongs to the dermatopontin family.

9595:DIS3
gene id: 9595:DIS3
uniprot id: A0A2I2Y578
uniprot id: G3QUT3
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9595:TAS1R2
gene id: 9595:TAS1R2
uniprot id: G3QS00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:MYOF
gene id: 9595:MYOF
uniprot id: G3RT91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:FOXP1
gene id: 9595:FOXP1
uniprot id: G3SIY1
names: Subcellular Location Annotation
messages: Nucleus

9595:ISL2
gene id: 9595:ISL2
uniprot id: G3SG14
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101134050
gene id: 9595:LOC101134050
uniprot id: G3S9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:OIP5
gene id: 9595:OIP5
uniprot id: G3QDK2
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9595:PKD2
gene id: 9595:PKD2
uniprot id: G3QLB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9595:TRUB2
gene id: 9595:TRUB2
uniprot id: G3RFP9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9595:STK39
gene id: 9595:STK39
uniprot id: G3SH11
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9595:TLE1
gene id: 9595:TLE1
uniprot id: G3QEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9595:PUF60
gene id: 9595:PUF60
uniprot id: A0A2I2Y9K9
uniprot id: A0A2I2ZC99
uniprot id: G3QPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9595:PRPSAP2
gene id: 9595:PRPSAP2
uniprot id: G3RH64
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9595:VPS26C
gene id: 9595:VPS26C
uniprot id: G3SB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9595:NCBP1
gene id: 9595:NCBP1
uniprot id: G3QGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9595:SV2C
gene id: 9595:SV2C
uniprot id: A0A2I2Z7Y3
uniprot id: G3QXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9595:UST
gene id: 9595:UST
uniprot id: A0A2I2Z3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9595:KCNE2
gene id: 9595:KCNE2
uniprot id: G3R277
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9595:GSTK1
gene id: 9595:GSTK1
uniprot id: A0A2I2Y8N2
uniprot id: G3R8V8
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9595:OSGEP
gene id: 9595:OSGEP
uniprot id: G3QI87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9595:DR1
gene id: 9595:DR1
uniprot id: G3SFJ8
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9595:ENTPD2
gene id: 9595:ENTPD2
uniprot id: G3R7S8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:AMOTL1
gene id: 9595:AMOTL1
uniprot id: A0A2I2Y6D1
uniprot id: G3RXQ2
names: Similarity
messages: Belongs to the angiomotin family.

9595:CCDC86
gene id: 9595:CCDC86
uniprot id: G3RCU9
names: Subcellular Location Annotation
messages: Nucleus

9595:PLA2G1B
gene id: 9595:PLA2G1B
uniprot id: G3QUX4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:CLDN11
gene id: 9595:CLDN11
uniprot id: A0A2I2ZIY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:JUP
gene id: 9595:JUP
uniprot id: G3R3M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9595:LUC7L
gene id: 9595:LUC7L
uniprot id: A0A2I2YWS1
uniprot id: G3RK35
names: Similarity
messages: Belongs to the Luc7 family.

9595:LIN7C
gene id: 9595:LIN7C
uniprot id: G3RYG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9595:XCR1
gene id: 9595:XCR1
uniprot id: G3S0Y6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SLC25A39
gene id: 9595:SLC25A39
uniprot id: A0A2I2YJU3
uniprot id: G3QSS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9595:EYA3
gene id: 9595:EYA3
uniprot id: A0A2I2YTG5
uniprot id: G3S1I3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9595:AMD1
gene id: 9595:AMD1
uniprot id: G3QUC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9595:CORIN
gene id: 9595:CORIN
uniprot id: A0A2I2Y6Z0
uniprot id: G3R6C3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AVL9
gene id: 9595:AVL9
uniprot id: A0A2I2ZID1
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9595:TEK
gene id: 9595:TEK
uniprot id: G3RIN5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DUSP6
gene id: 9595:DUSP6
uniprot id: G3SCU3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:GABRG2
gene id: 9595:GABRG2
uniprot id: A0A2I2YBS2
uniprot id: G3R6I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:UBE2M
gene id: 9595:UBE2M
uniprot id: G3RC12
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:IPO9
gene id: 9595:IPO9
uniprot id: G3QV84
names: Subcellular Location Annotation
messages: Cytoplasm

9595:TIMM8B
gene id: 9595:TIMM8B
uniprot id: A0A2I2Z2U1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9595:RBPJL
gene id: 9595:RBPJL
uniprot id: G3QNF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9595:UBN1
gene id: 9595:UBN1
uniprot id: G3R9Y9
names: Similarity
messages: Belongs to the ubinuclein family.

9595:ME2
gene id: 9595:ME2
uniprot id: G3R5I4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9595:SLC19A2
gene id: 9595:SLC19A2
uniprot id: G3SC76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9595:MFSD14A
gene id: 9595:MFSD14A
uniprot id: G3QF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9595:MYO5B
gene id: 9595:MYO5B
uniprot id: G3QZT8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:HMGCR
gene id: 9595:HMGCR
uniprot id: G3R5R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9595:SDC1
gene id: 9595:SDC1
uniprot id: A0A2I2YZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

9595:AHR
gene id: 9595:AHR
uniprot id: G3S4Z4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:EYA2
gene id: 9595:EYA2
uniprot id: G3SKP8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9595:PARP1
gene id: 9595:PARP1
uniprot id: G3SBV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9595:TMEM132D
gene id: 9595:TMEM132D
uniprot id: G3R039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9595:BLVRA
gene id: 9595:BLVRA
uniprot id: A0A2I2Z6L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9595:COG4
gene id: 9595:COG4
uniprot id: A0A2I2YQ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9595:KEG83 p13
gene id: 9595:KEG83_p13
uniprot id: G3RRH4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9595:PSMD1
gene id: 9595:PSMD1
uniprot id: G3RVS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9595:POU3F4
gene id: 9595:POU3F4
uniprot id: A0A2I2YJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9595:TSHZ2
gene id: 9595:TSHZ2
uniprot id: A0A2I2Z7T6
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9595:SNRPG
gene id: 9595:SNRPG
uniprot id: A0A2I2YEA9
uniprot id: A0A2I2Z4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9595:SH3BP4
gene id: 9595:SH3BP4
uniprot id: G3RCE8
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9595:UBE2K
gene id: 9595:UBE2K
uniprot id: G3QL63
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:PARP9
gene id: 9595:PARP9
uniprot id: G3RIR3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:LPXN
gene id: 9595:LPXN
uniprot id: G3QHQ4
uniprot id: G3S2X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9595:ASIP
gene id: 9595:ASIP
uniprot id: G3SDS8
names: Subcellular Location Annotation
messages: Secreted

9595:LOC101148837
gene id: 9595:LOC101148837
uniprot id: G3S8Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FAT4
gene id: 9595:FAT4
uniprot id: A0A2I2YI73
uniprot id: G3RBU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TMEM176A
gene id: 9595:TMEM176A
uniprot id: A0A2I2ZV82
names: Similarity
messages: Belongs to the TMEM176 family.

9595:MACF1
gene id: 9595:MACF1
uniprot id: G3RJN1
names: Subcellular Location Annotation
messages: cytoskeleton

9595:SLIT1
gene id: 9595:SLIT1
uniprot id: A0A2I2YCZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:FOXJ1
gene id: 9595:FOXJ1
uniprot id: G3QWG5
names: Subcellular Location Annotation
messages: Nucleus

9595:KAT2A
gene id: 9595:KAT2A
uniprot id: G3QRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9595:EHD3
gene id: 9595:EHD3
uniprot id: G3QKK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9595:APCS
gene id: 9595:APCS
uniprot id: G3QGL3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9595:EFEMP1
gene id: 9595:EFEMP1
uniprot id: G3RW79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TADA2A
gene id: 9595:TADA2A
uniprot id: G3R913
names: Subcellular Location Annotation
messages: Nucleus

9595:RIPPLY3
gene id: 9595:RIPPLY3
uniprot id: A0A2I2YU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9595:LOC101136189
gene id: 9595:LOC101136189
uniprot id: A0A2I2YVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:VPS16
gene id: 9595:VPS16
uniprot id: G3RJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9595:WDR76
gene id: 9595:WDR76
uniprot id: G3QTT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9595:MAB21L3
gene id: 9595:MAB21L3
uniprot id: G3QIQ7
names: Similarity
messages: Belongs to the mab-21 family.

9595:CBS
gene id: 9595:CBS
uniprot id: G3RQH5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9595:MTERF3
gene id: 9595:MTERF3
uniprot id: G3R7B6
names: Similarity
messages: Belongs to the mTERF family.

9595:PAGE1
gene id: 9595:PAGE1
uniprot id: G3QY22
names: Similarity
messages: Belongs to the GAGE family.

9595:LOC101137477
gene id: 9595:LOC101137477
uniprot id: G3RZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CHEK1
gene id: 9595:CHEK1
uniprot id: G3RMW4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9595:SUSD5
gene id: 9595:SUSD5
uniprot id: A0A2I2YKD5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ELMO1
gene id: 9595:ELMO1
uniprot id: G3RL99
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9595:PADI1
gene id: 9595:PADI1
uniprot id: G3RGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:TNN
gene id: 9595:TNN
uniprot id: G3RBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9595:SELL
gene id: 9595:SELL
uniprot id: G3RND1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101133649
gene id: 9595:LOC101133649
uniprot id: P61638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:PLIN1
gene id: 9595:PLIN1
uniprot id: G3S7F6
names: Similarity
messages: Belongs to the perilipin family.

9595:TMEM167B
gene id: 9595:TMEM167B
uniprot id: A0A2I2ZV03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:UBIAD1
gene id: 9595:UBIAD1
uniprot id: A0A2I2Z6H6
uniprot id: G3QG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9595:SLC13A3
gene id: 9595:SLC13A3
uniprot id: G3QP81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9595:NANOG
gene id: 9595:NANOG
uniprot id: G3S4N9
names: Subcellular Location Annotation
messages: Nucleus

9595:SH2B3
gene id: 9595:SH2B3
uniprot id: A0A2I2Z002
names: Similarity
messages: Belongs to the SH2B adapter family.

9595:RTCA
gene id: 9595:RTCA
uniprot id: G3R285
uniprot id: G3SGY2
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9595:INO80C
gene id: 9595:INO80C
uniprot id: G3RZA7
uniprot id: G3SIV1
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101129166
gene id: 9595:LOC101129166
uniprot id: G3RKB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CHRNB2
gene id: 9595:CHRNB2
uniprot id: G3QW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:SLC22A18
gene id: 9595:SLC22A18
uniprot id: G3QYX3
names: Subcellular Location Annotation
messages: Membrane

9595:IDH3G
gene id: 9595:IDH3G
uniprot id: A0A2I2ZXN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9595:INHA
gene id: 9595:INHA
uniprot id: G3QM12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9595:HEPHL1
gene id: 9595:HEPHL1
uniprot id: G3SBH1
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:GABRG1
gene id: 9595:GABRG1
uniprot id: A0A2I2ZBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:TNFRSF21
gene id: 9595:TNFRSF21
uniprot id: A0A2I2Z0W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ATP5PF
gene id: 9595:ATP5PF
uniprot id: G3SFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9595:SOX8
gene id: 9595:SOX8
uniprot id: G3S0X8
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC39A6
gene id: 9595:SLC39A6
uniprot id: G3R4A7
names: Subcellular Location Annotation
messages: Membrane

9595:AGT
gene id: 9595:AGT
uniprot id: Q9GLP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor.
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).
messages: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
messages: Secreted
messages: Stimulates aldosterone release.
messages: The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin (By similarity).

9595:CHRM5
gene id: 9595:CHRM5
uniprot id: G3RNL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9595:LOC101131142
gene id: 9595:LOC101131142
uniprot id: G3QJL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9595:MAPK7
gene id: 9595:MAPK7
uniprot id: G3QTA1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9595:ARPC5
gene id: 9595:ARPC5
uniprot id: G3QY01
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9595:MAP3K11
gene id: 9595:MAP3K11
uniprot id: G3R7Y7
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9595:CAMK1D
gene id: 9595:CAMK1D
uniprot id: G3RK85
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:KCNC2
gene id: 9595:KCNC2
uniprot id: A0A2I2Y5C0
uniprot id: A0A2I2YUP3
uniprot id: A0A2I2Z6X8
uniprot id: A0A2I2ZS76
uniprot id: G3S3N7
names: Subcellular Location Annotation
messages: Membrane

9595:EXOSC4
gene id: 9595:EXOSC4
uniprot id: G3R4L8
names: Subcellular Location Annotation
messages: Cytoplasm

9595:GINS3
gene id: 9595:GINS3
uniprot id: G3S1X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9595:PGGT1B
gene id: 9595:PGGT1B
uniprot id: G3QFM5
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9595:MAP4K2
gene id: 9595:MAP4K2
uniprot id: G3QKE8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9595:RNASEH2B
gene id: 9595:RNASEH2B
uniprot id: A0A2I2YP62
uniprot id: G3QFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9595:ACAA1
gene id: 9595:ACAA1
uniprot id: G3QML6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:UBLCP1
gene id: 9595:UBLCP1
uniprot id: G3RF15
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9595:API5
gene id: 9595:API5
uniprot id: A0A2I2YNY1
names: Similarity
messages: Belongs to the API5 family.

9595:LAMA1
gene id: 9595:LAMA1
uniprot id: G3RYE2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9595:CLDN10
gene id: 9595:CLDN10
uniprot id: A0A2I2Y969
uniprot id: G3SE82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:XPA
gene id: 9595:XPA
uniprot id: A0A2I2Y279
uniprot id: G3QGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9595:CCL16
gene id: 9595:CCL16
uniprot id: A0A2I2YNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:LOC101152650
gene id: 9595:LOC101152650
uniprot id: G3S6G5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:NINJ2
gene id: 9595:NINJ2
uniprot id: G3QJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9595:NELL2
gene id: 9595:NELL2
uniprot id: A0A2I2Y6W4
uniprot id: A0A2I2Z2V4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FGFR1OP
gene id: 9595:FGFR1OP
uniprot id: A0A2I2ZG60
uniprot id: A0A2I2ZH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9595:SOX14
gene id: 9595:SOX14
uniprot id: G3RDD2
names: Subcellular Location Annotation
messages: Nucleus

9595:MOSPD1
gene id: 9595:MOSPD1
uniprot id: A0A2I2YJN6
uniprot id: G3QMM4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9595:CLCN1
gene id: 9595:CLCN1
uniprot id: G3R6J1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DYNC1I2
gene id: 9595:DYNC1I2
uniprot id: A0A2I2YA06
uniprot id: A0A2I2Z8V6
uniprot id: G3QJQ7
uniprot id: G3SFG3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9595:ANXA2
gene id: 9595:ANXA2
uniprot id: G3S932
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9595:STK17B
gene id: 9595:STK17B
uniprot id: G3RKZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:PRF1
gene id: 9595:PRF1
uniprot id: G3QHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9595:ALG3
gene id: 9595:ALG3
uniprot id: G3QX68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CILP
gene id: 9595:CILP
uniprot id: A0A2I2YZ36
names: Subcellular Location Annotation
messages: extracellular matrix

9595:AGTRAP
gene id: 9595:AGTRAP
uniprot id: G3S5X3
names: Subcellular Location Annotation
messages: Membrane

9595:ARL2
gene id: 9595:ARL2
uniprot id: A0A2I2Y999
uniprot id: G3QRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9595:CTNNBIP1
gene id: 9595:CTNNBIP1
uniprot id: A0A2I2YTS2
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9595:SDR16C5
gene id: 9595:SDR16C5
uniprot id: G3QN45
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SLC24A2
gene id: 9595:SLC24A2
uniprot id: A0A2I2Z4V7
uniprot id: G3RK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:SLC44A3
gene id: 9595:SLC44A3
uniprot id: G3RDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9595:SAMD8
gene id: 9595:SAMD8
uniprot id: A0A2I2YQC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9595:MRPL46
gene id: 9595:MRPL46
uniprot id: G3RGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9595:GLCE
gene id: 9595:GLCE
uniprot id: G3RKT8
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9595:TSPYL6
gene id: 9595:TSPYL6
uniprot id: G3QKY2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9595:MOG
gene id: 9595:MOG
uniprot id: A0A2I2Z2U8
uniprot id: G3S9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9595:HLCS
gene id: 9595:HLCS
uniprot id: G3R6B1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9595:AQP1
gene id: 9595:AQP1
uniprot id: G3R332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

9595:CASTOR1
gene id: 9595:CASTOR1
uniprot id: A0A2I2Z0D1
uniprot id: G3QW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9595:CZIB
gene id: 9595:CZIB
uniprot id: A0A2I2YIZ0
uniprot id: G3QN47
names: Similarity
messages: Belongs to the UPF0587 family.

9595:LOC101151556
gene id: 9595:LOC101151556
uniprot id: G3R5Y1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:LDB1
gene id: 9595:LDB1
uniprot id: A0A2I2YLN1
uniprot id: G3QIB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9595:C2BH2orf76
gene id: 9595:C2BH2orf76
uniprot id: G3QEX3
names: Similarity
messages: Belongs to the UPF0538 family.

9595:RPS19
gene id: 9595:RPS19
uniprot id: G3RGZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9595:IDH3B
gene id: 9595:IDH3B
uniprot id: A0A2I2Y4G9
uniprot id: G3R3G3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9595:MED6
gene id: 9595:MED6
uniprot id: A0A2I2Z7F9
uniprot id: A0A2I2ZB28
uniprot id: G3QU08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9595:TMED10
gene id: 9595:TMED10
uniprot id: G3RRB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CCNA2
gene id: 9595:CCNA2
uniprot id: G3QIC8
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9595:ADCYAP1
gene id: 9595:ADCYAP1
uniprot id: A0A2I2ZFM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9595:SATB2
gene id: 9595:SATB2
uniprot id: A0A2I2Z942
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9595:TM6SF1
gene id: 9595:TM6SF1
uniprot id: G3RGB0
names: Subcellular Location Annotation
messages: Membrane

9595:PCNX3
gene id: 9595:PCNX3
uniprot id: G3SFE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9595:ATP10A
gene id: 9595:ATP10A
uniprot id: G3QHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9595:TIMM17A
gene id: 9595:TIMM17A
uniprot id: G3QZB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9595:MAU2
gene id: 9595:MAU2
uniprot id: A0A2I2Z2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9595:FGG
gene id: 9595:FGG
uniprot id: A0A2I2YC21
uniprot id: G3R8D4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9595:SLC25A23
gene id: 9595:SLC25A23
uniprot id: G3QVW8
uniprot id: G3S9R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:NUDT12
gene id: 9595:NUDT12
uniprot id: G3RRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9595:GLS2
gene id: 9595:GLS2
uniprot id: G3RKB6
names: Similarity
messages: Belongs to the glutaminase family.

9595:RAE1
gene id: 9595:RAE1
uniprot id: G3QXR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

9595:PTK2
gene id: 9595:PTK2
uniprot id: G3S1C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9595:CDKN1B
gene id: 9595:CDKN1B
uniprot id: G3SDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9595:DCST2
gene id: 9595:DCST2
uniprot id: G3RDB7
names: Subcellular Location Annotation
messages: Membrane

9595:NXPE4
gene id: 9595:NXPE4
uniprot id: G3R0G2
names: Similarity
messages: Belongs to the NXPE family.

9595:CCN5
gene id: 9595:CCN5
uniprot id: A0A2I2ZRV7
names: Similarity
messages: Belongs to the CCN family.

9595:C12H12orf65
gene id: 9595:C12H12orf65
uniprot id: G3RAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9595:CDSN
gene id: 9595:CDSN
uniprot id: G3S1W3
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9595:ABRACL
gene id: 9595:ABRACL
uniprot id: G3R0S3
names: Similarity
messages: Belongs to the costars family.

9595:ZDHHC24
gene id: 9595:ZDHHC24
uniprot id: G3RIT0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:AKR1D1
gene id: 9595:AKR1D1
uniprot id: G3RFG2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:ULK2
gene id: 9595:ULK2
uniprot id: A0A2I2Z864
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Serine/threonine-protein kinase involved in autophagy in response to starvation.

9595:NMNAT3
gene id: 9595:NMNAT3
uniprot id: G3RQH0
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9595:SAP18
gene id: 9595:SAP18
uniprot id: G3RF20
names: Similarity
messages: Belongs to the SAP18 family.

9595:NR3C1
gene id: 9595:NR3C1
uniprot id: A0A2I2YDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9595:STX17
gene id: 9595:STX17
uniprot id: G3RAT0
names: Similarity
messages: Belongs to the syntaxin family.

9595:FAXC
gene id: 9595:FAXC
uniprot id: A0A2I2Z1P2
names: Similarity
messages: Belongs to the FAX family.

9595:LOC101133282
gene id: 9595:LOC101133282
uniprot id: G3SHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RBFOX1
gene id: 9595:RBFOX1
uniprot id: A0A2I2Z094
uniprot id: A0A2I2ZYE3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9595:TRAF1
gene id: 9595:TRAF1
uniprot id: G3QIN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9595:CPLX1
gene id: 9595:CPLX1
uniprot id: G3S2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:CCDC188
gene id: 9595:CCDC188
uniprot id: G3SKC5
names: Subcellular Location Annotation
messages: Membrane

9595:PDHX
gene id: 9595:PDHX
uniprot id: A0A2I2Z7A6
uniprot id: G3QFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9595:COQ8A
gene id: 9595:COQ8A
uniprot id: A0A2I2Y561
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9595:ASTL
gene id: 9595:ASTL
uniprot id: G3R9B1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101146993
gene id: 9595:LOC101146993
uniprot id: G3QPY2
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SLC7A5
gene id: 9595:SLC7A5
uniprot id: G3SJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9595:ATP5MC2
gene id: 9595:ATP5MC2
uniprot id: G3RHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9595:LOC101146219
gene id: 9595:LOC101146219
uniprot id: Q4QXU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.

9595:LOC101132466
gene id: 9595:LOC101132466
uniprot id: G3R4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9595:USB1
gene id: 9595:USB1
uniprot id: A0A2I2YWK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9595:SMC5
gene id: 9595:SMC5
uniprot id: A0A2I2ZDE4
uniprot id: G3RKD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9595:F2
gene id: 9595:F2
uniprot id: G3QVP5
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9595:MTX3
gene id: 9595:MTX3
uniprot id: G3QMU5
uniprot id: G3SFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:HAUS3
gene id: 9595:HAUS3
uniprot id: G3QEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9595:ZDHHC22
gene id: 9595:ZDHHC22
uniprot id: G3R3R5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:FAM168B
gene id: 9595:FAM168B
uniprot id: G3QCX4
names: Similarity
messages: Belongs to the FAM168 family.

9595:PPRC1
gene id: 9595:PPRC1
uniprot id: A0A2I2YUV5
uniprot id: A0A2I2ZSY4
uniprot id: G3QIB7
names: Subcellular Location Annotation
messages: Nucleus

9595:AHSA1
gene id: 9595:AHSA1
uniprot id: G3QXU4
names: Similarity
messages: Belongs to the AHA1 family.

9595:GYS1
gene id: 9595:GYS1
uniprot id: A0A2I2ZL86
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9595:PLSCR5
gene id: 9595:PLSCR5
uniprot id: A0A2I2YPM1
uniprot id: G3RZ11
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9595:GADD45A
gene id: 9595:GADD45A
uniprot id: G3R5D8
names: Similarity
messages: Belongs to the GADD45 family.

9595:OPLAH
gene id: 9595:OPLAH
uniprot id: G3RIV3
names: Similarity
messages: Belongs to the oxoprolinase family.

9595:CBR1
gene id: 9595:CBR1
uniprot id: G3QKD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9595:CEP162
gene id: 9595:CEP162
uniprot id: G3QWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9595:GOT1
gene id: 9595:GOT1
uniprot id: G3QJC1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9595:ATP6V0A4
gene id: 9595:ATP6V0A4
uniprot id: G3R0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9595:LOC101143734
gene id: 9595:LOC101143734
uniprot id: G3QSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:YPEL4
gene id: 9595:YPEL4
uniprot id: G3RY61
names: Similarity
messages: Belongs to the yippee family.

9595:GDPD1
gene id: 9595:GDPD1
uniprot id: A0A2I2YEU8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:POLR2G
gene id: 9595:POLR2G
uniprot id: G3R7V2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9595:F11R
gene id: 9595:F11R
uniprot id: G3SFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:KCNJ3
gene id: 9595:KCNJ3
uniprot id: G3SFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9595:TMEM170A
gene id: 9595:TMEM170A
uniprot id: A0A2I2YFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9595:FAM20A
gene id: 9595:FAM20A
uniprot id: G3QKR8
names: Similarity
messages: Belongs to the FAM20 family.

9595:ATAD2B
gene id: 9595:ATAD2B
uniprot id: G3QT86
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:LOC101152116
gene id: 9595:LOC101152116
uniprot id: G3RF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PLP1
gene id: 9595:PLP1
uniprot id: G3RK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9595:PIK3CD
gene id: 9595:PIK3CD
uniprot id: A0A2I2ZMF3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:HAT1
gene id: 9595:HAT1
uniprot id: A0A2I2ZE90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9595:VPS33A
gene id: 9595:VPS33A
uniprot id: G3QRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9595:NIPSNAP3B
gene id: 9595:NIPSNAP3B
uniprot id: A0A2I2YHN6
names: Similarity
messages: Belongs to the NipSnap family.

9595:KATNB1
gene id: 9595:KATNB1
uniprot id: G3QW37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9595:PCLO
gene id: 9595:PCLO
uniprot id: G3QNK0
names: Subcellular Location Annotation
messages: Presynaptic active zone

9595:PTPRZ1
gene id: 9595:PTPRZ1
uniprot id: G3SHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9595:RGS2
gene id: 9595:RGS2
uniprot id: G3QJV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9595:C10H10orf53
gene id: 9595:C10H10orf53
uniprot id: A0A2I2Z7V0
uniprot id: G3RMH5
names: Similarity
messages: Belongs to the UPF0728 family.

9595:LOC101144277
gene id: 9595:LOC101144277
uniprot id: Q8SQ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:MCM2
gene id: 9595:MCM2
uniprot id: G3RFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9595:TIPRL
gene id: 9595:TIPRL
uniprot id: A0A2I2ZB16
uniprot id: G3RB38
names: Similarity
messages: Belongs to the TIP41 family.

9595:KRT71
gene id: 9595:KRT71
uniprot id: G3QKU5
names: Similarity
messages: Belongs to the intermediate filament family.

9595:PYY
gene id: 9595:PYY
uniprot id: G3R0I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9595:CEP70
gene id: 9595:CEP70
uniprot id: G3R5C7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9595:C1H1orf174
gene id: 9595:C1H1orf174
uniprot id: G3RCA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9595:PLB1
gene id: 9595:PLB1
uniprot id: G3RKZ1
uniprot id: G3S244
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Cell membrane
messages: Membrane

9595:SLC35C2
gene id: 9595:SLC35C2
uniprot id: A0A2I2ZAS0
names: Subcellular Location Annotation
messages: Membrane

9595:RXRB
gene id: 9595:RXRB
uniprot id: G3R2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9595:GSX2
gene id: 9595:GSX2
uniprot id: G3QY28
names: Subcellular Location Annotation
messages: Nucleus

9595:MRPS7
gene id: 9595:MRPS7
uniprot id: G3QXD3
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9595:PTDSS1
gene id: 9595:PTDSS1
uniprot id: G3SCJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:IQSEC3
gene id: 9595:IQSEC3
uniprot id: G3S130
names: Similarity
messages: Belongs to the BRAG family.

9595:SPR
gene id: 9595:SPR
uniprot id: G3QSC9
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9595:CXCL10
gene id: 9595:CXCL10
uniprot id: G3R4U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:B3GNT7
gene id: 9595:B3GNT7
uniprot id: G3R4F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:MS4A10
gene id: 9595:MS4A10
uniprot id: A0A2I2ZBN5
names: Similarity
messages: Belongs to the MS4A family.

9595:UBALD1
gene id: 9595:UBALD1
uniprot id: A0A2I2YYH8
names: Similarity
messages: Belongs to the UBALD family.

9595:LOC101150014
gene id: 9595:LOC101150014
uniprot id: G3R849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC109023678
gene id: 9595:LOC109023678
uniprot id: G3RQM3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:LOC101142266
gene id: 9595:LOC101142266
uniprot id: A0A2I2YQV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RPS13
gene id: 9595:RPS13
uniprot id: G3QWW5
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9595:CBR3
gene id: 9595:CBR3
uniprot id: G3REK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9595:HCRT
gene id: 9595:HCRT
uniprot id: G3SG65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9595:HMGB2
gene id: 9595:HMGB2
uniprot id: G3RII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9595:PREPL
gene id: 9595:PREPL
uniprot id: G3QWD0
names: Similarity
messages: Belongs to the peptidase S9A family.

9595:GRIA2
gene id: 9595:GRIA2
uniprot id: G3RAA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:TRARG1
gene id: 9595:TRARG1
uniprot id: G3SCX6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:SERPINB13
gene id: 9595:SERPINB13
uniprot id: G3RH08
names: Similarity
messages: Belongs to the serpin family.

9595:AK3
gene id: 9595:AK3
uniprot id: G3S5H3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9595:RIPOR2
gene id: 9595:RIPOR2
uniprot id: A0A2I2ZIW7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9595:NME9
gene id: 9595:NME9
uniprot id: A0A2I2YW59
names: Similarity
messages: Belongs to the NDK family.

9595:GRM2
gene id: 9595:GRM2
uniprot id: G3R3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:DSEL
gene id: 9595:DSEL
uniprot id: A0A2I2YEY8
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9595:ITGA7
gene id: 9595:ITGA7
uniprot id: A0A2I2YSG4
uniprot id: A0A2I2Z3P5
uniprot id: A0A2I2ZTX6
uniprot id: G3QKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:SEMA4F
gene id: 9595:SEMA4F
uniprot id: A0A2I2Z131
uniprot id: A0A2I2ZT63
uniprot id: G3RBD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SUDS3
gene id: 9595:SUDS3
uniprot id: G3R5Z9
names: Subcellular Location Annotation
messages: Nucleus

9595:SUCLG1
gene id: 9595:SUCLG1
uniprot id: G3QI12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9595:DLX3
gene id: 9595:DLX3
uniprot id: G3RG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:CHSY1
gene id: 9595:CHSY1
uniprot id: G3R0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9595:PLA2G3
gene id: 9595:PLA2G3
uniprot id: G3RX58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9595:YIPF4
gene id: 9595:YIPF4
uniprot id: G3R901
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9595:PPP1R16B
gene id: 9595:PPP1R16B
uniprot id: G3RI06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:PTCD3
gene id: 9595:PTCD3
uniprot id: G3QHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9595:GPD2
gene id: 9595:GPD2
uniprot id: G3RU77
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9595:MDK
gene id: 9595:MDK
uniprot id: G3S2W7
names: Similarity
messages: Belongs to the pleiotrophin family.

9595:PACSIN1
gene id: 9595:PACSIN1
uniprot id: G3RRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9595:PJVK
gene id: 9595:PJVK
uniprot id: G3R652
names: Similarity
messages: Belongs to the gasdermin family.

9595:DTX3
gene id: 9595:DTX3
uniprot id: G3QKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9595:RARRES2
gene id: 9595:RARRES2
uniprot id: G3R6C5
names: Subcellular Location Annotation
messages: Secreted

9595:SNX2
gene id: 9595:SNX2
uniprot id: G3QIZ7
names: Similarity
messages: Belongs to the sorting nexin family.

9595:TAS2R38
gene id: 9595:TAS2R38
uniprot id: A0A2K5TIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9595:KIF9
gene id: 9595:KIF9
uniprot id: G3QM86
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:FAM234A
gene id: 9595:FAM234A
uniprot id: G3RC02
names: Similarity
messages: Belongs to the FAM234 family.

9595:RDH11
gene id: 9595:RDH11
uniprot id: G3QS80
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:CDK7
gene id: 9595:CDK7
uniprot id: G3RC03
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9595:RETNLB
gene id: 9595:RETNLB
uniprot id: G3R311
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9595:LOC101128557
gene id: 9595:LOC101128557
uniprot id: G3S5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ST7
gene id: 9595:ST7
uniprot id: A0A2I2YR23
uniprot id: A0A2I2ZW51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9595:UCP2
gene id: 9595:UCP2
uniprot id: G3QMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:URAD
gene id: 9595:URAD
uniprot id: G3QRV7
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9595:PDC
gene id: 9595:PDC
uniprot id: G3SAB6
names: Similarity
messages: Belongs to the phosducin family.

9595:UTP6
gene id: 9595:UTP6
uniprot id: G3RCL0
names: Similarity
messages: Belongs to the UTP6 family.

9595:MPP6
gene id: 9595:MPP6
uniprot id: G3QR22
names: Similarity
messages: Belongs to the MAGUK family.

9595:ATXN3
gene id: 9595:ATXN3
uniprot id: A0A2I2YJG1
uniprot id: A0A2I2ZJ77
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:USP9X
gene id: 9595:USP9X
uniprot id: G3SIQ8
names: Similarity
messages: Belongs to the peptidase C19 family.

9595:PIGZ
gene id: 9595:PIGZ
uniprot id: G3QUW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:FAM174B
gene id: 9595:FAM174B
uniprot id: G3QRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9595:SEPTIN5
gene id: 9595:SEPTIN5
uniprot id: G3S5Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cytoskeleton

9595:ZNF24
gene id: 9595:ZNF24
uniprot id: A0A2I2Y5T7
names: Subcellular Location Annotation
messages: Nucleus

9595:LBX1
gene id: 9595:LBX1
uniprot id: G3R9W2
names: Subcellular Location Annotation
messages: Nucleus

9595:PSMB5
gene id: 9595:PSMB5
uniprot id: G3S725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:PFDN6
gene id: 9595:PFDN6
uniprot id: A0A2I2YD85
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9595:UBA3
gene id: 9595:UBA3
uniprot id: A0A2I2ZDY8
uniprot id: G3QMY7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9595:HOMER3
gene id: 9595:HOMER3
uniprot id: G3RT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9595:ATF7IP2
gene id: 9595:ATF7IP2
uniprot id: A0A2I2YGC2
uniprot id: A0A2I2ZNP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9595:CDK1
gene id: 9595:CDK1
uniprot id: G3RBW7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:MMP20
gene id: 9595:MMP20
uniprot id: G3QLA8
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:KCNJ10
gene id: 9595:KCNJ10
uniprot id: G3S8U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:FAM160A1
gene id: 9595:FAM160A1
uniprot id: G3RKA8
names: Similarity
messages: Belongs to the FHIP family.

9595:MYBL1
gene id: 9595:MYBL1
uniprot id: A0A2I2ZYZ0
uniprot id: G3SHW4
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM8A1
gene id: 9595:FAM8A1
uniprot id: G3S6H9
names: Subcellular Location Annotation
messages: Membrane

9595:AGXT
gene id: 9595:AGXT
uniprot id: G3RFG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9595:DPM1
gene id: 9595:DPM1
uniprot id: A0A2I2ZNK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9595:CNOT9
gene id: 9595:CNOT9
uniprot id: A0A2I2Y9V2
uniprot id: A0A2I2ZFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9595:SFTPD
gene id: 9595:SFTPD
uniprot id: G3R0R1
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9595:CDC42
gene id: 9595:CDC42
uniprot id: A0A2I2Z2P0
uniprot id: A0A2I2Z7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9595:SLC27A1
gene id: 9595:SLC27A1
uniprot id: G3QQK0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:TFCP2L1
gene id: 9595:TFCP2L1
uniprot id: G3RZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9595:TXLNA
gene id: 9595:TXLNA
uniprot id: G3QGT7
names: Similarity
messages: Belongs to the taxilin family.

9595:LOC101137282
gene id: 9595:LOC101137282
uniprot id: G3RGX1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:SELENBP1
gene id: 9595:SELENBP1
uniprot id: G3SB02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9595:VLDLR
gene id: 9595:VLDLR
uniprot id: A0A2I2ZM49
uniprot id: G3QG94
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: clathrin-coated pit

9595:SLC25A16
gene id: 9595:SLC25A16
uniprot id: G3SAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:CENPK
gene id: 9595:CENPK
uniprot id: G3QQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9595:GPR137
gene id: 9595:GPR137
uniprot id: A0A2I2YZB0
uniprot id: G3R979
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9595:BIRC2
gene id: 9595:BIRC2
uniprot id: G3QZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9595:EIF4A2
gene id: 9595:EIF4A2
uniprot id: G3QSU6
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9595:SLC52A1
gene id: 9595:SLC52A1
uniprot id: G3RHZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9595:AGXT2
gene id: 9595:AGXT2
uniprot id: G3QUN3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9595:PPA1
gene id: 9595:PPA1
uniprot id: G3RLE5
names: Similarity
messages: Belongs to the PPase family.

9595:JAKMIP2
gene id: 9595:JAKMIP2
uniprot id: A0A2I2Y6S6
uniprot id: A0A2I2YYU7
uniprot id: A0A2I2ZJ16
uniprot id: G3QLK9
names: Similarity
messages: Belongs to the JAKMIP family.

9595:KAT7
gene id: 9595:KAT7
uniprot id: A0A2I2ZH11
uniprot id: G3SCG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9595:LOC101150373
gene id: 9595:LOC101150373
uniprot id: G3RJE1
names: Subcellular Location Annotation
messages: Membrane

9595:MARK1
gene id: 9595:MARK1
uniprot id: A0A2I2Z1R1
uniprot id: G3QF81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:CDR2
gene id: 9595:CDR2
uniprot id: G3RCU4
names: Similarity
messages: Belongs to the CDR2 family.

9595:LCTL
gene id: 9595:LCTL
uniprot id: G3QU26
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9595:NIP7
gene id: 9595:NIP7
uniprot id: G3RX93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9595:IL5RA
gene id: 9595:IL5RA
uniprot id: A0A2I2YBR3
uniprot id: A0A2I2ZZ52
uniprot id: G3QFI9
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9595:HBQ1
gene id: 9595:HBQ1
uniprot id: G3RJU5
names: Similarity
messages: Belongs to the globin family.

9595:ITIH1
gene id: 9595:ITIH1
uniprot id: G3QSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9595:BDNF
gene id: 9595:BDNF
uniprot id: A0A2I2Y601
uniprot id: A0A2I2YAV7
uniprot id: A0A2I2YYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9595:AGL
gene id: 9595:AGL
uniprot id: A0A2I2YDM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9595:ZKSCAN4
gene id: 9595:ZKSCAN4
uniprot id: G3RTP5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101149201
gene id: 9595:LOC101149201
uniprot id: G3RHW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PDCD11
gene id: 9595:PDCD11
uniprot id: G3R7L4
names: Subcellular Location Annotation
messages: nucleolus

9595:EPHA1
gene id: 9595:EPHA1
uniprot id: G3QCY0
names: Subcellular Location Annotation
messages: Membrane

9595:BCL9
gene id: 9595:BCL9
uniprot id: G3R1L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9595:OSBPL11
gene id: 9595:OSBPL11
uniprot id: G3QX33
names: Similarity
messages: Belongs to the OSBP family.

9595:FREM1
gene id: 9595:FREM1
uniprot id: G3RFK3
names: Similarity
messages: Belongs to the FRAS1 family.

9595:TJP2
gene id: 9595:TJP2
uniprot id: A0A2I2ZAR7
uniprot id: A0A2I2ZAW3
uniprot id: A0A2I2ZVU8
uniprot id: G3SE59
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:SNX18
gene id: 9595:SNX18
uniprot id: A0A2I2Y5F5
names: Similarity
messages: Belongs to the sorting nexin family.

9595:MINDY3
gene id: 9595:MINDY3
uniprot id: G3R5Q3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9595:PROK1
gene id: 9595:PROK1
uniprot id: G3QZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9595:DNAAF4
gene id: 9595:DNAAF4
uniprot id: A0A2I2ZXF6
uniprot id: G3QRQ2
uniprot id: Q863A5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with ZMYND10 (By similarity). Interacts with STUB1 (By similarity). Interacts with ESR1 and ESR2. Interacts with DNAAF2 (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (By similarity). Interacts with DNAAF6/PIH1D3 (By similarity).
messages: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).
messages: Nucleus
messages: neuron projection

9595:GINS1
gene id: 9595:GINS1
uniprot id: G3QJ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9595:SNX20
gene id: 9595:SNX20
uniprot id: A0A2I2Z817
uniprot id: A0A2I2ZV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9595:PSMA8
gene id: 9595:PSMA8
uniprot id: G3RJT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:CDH1
gene id: 9595:CDH1
uniprot id: G3QT90
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9595:C9H9orf64
gene id: 9595:C9H9orf64
uniprot id: G3R6P5
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9595:NAA35
gene id: 9595:NAA35
uniprot id: G3R7B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9595:AKAP5
gene id: 9595:AKAP5
uniprot id: G3SEG4
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101133280
gene id: 9595:LOC101133280
uniprot id: A0A2I2Y3I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:DEFB132
gene id: 9595:DEFB132
uniprot id: A4H262
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:AMIGO2
gene id: 9595:AMIGO2
uniprot id: A0A2I2ZSR1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9595:RPL14
gene id: 9595:RPL14
uniprot id: G3S186
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9595:CLIC5
gene id: 9595:CLIC5
uniprot id: G3RBM4
uniprot id: G3SBW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9595:ADAM29
gene id: 9595:ADAM29
uniprot id: G3R6U2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TSPAN17
gene id: 9595:TSPAN17
uniprot id: A0A2I2ZDV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:CD1D
gene id: 9595:CD1D
uniprot id: G3R7Y4
names: Similarity
messages: Belongs to the MHC class I family.

9595:LOC101134144
gene id: 9595:LOC101134144
uniprot id: G3QFX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9595:HTR1D
gene id: 9595:HTR1D
uniprot id: G3QIH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9595:DEFB119
gene id: 9595:DEFB119
uniprot id: A4H225
uniprot id: G3QRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:IMP3
gene id: 9595:IMP3
uniprot id: A0A2I2ZCU7
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9595:SLC7A7
gene id: 9595:SLC7A7
uniprot id: G3QM98
names: Subcellular Location Annotation
messages: Membrane

9595:KIF3A
gene id: 9595:KIF3A
uniprot id: G3QY97
uniprot id: G3S0E8
uniprot id: G3SK66
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:LOC101148834
gene id: 9595:LOC101148834
uniprot id: G3QEE4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9595:HAL
gene id: 9595:HAL
uniprot id: A0A2I2YY58
uniprot id: G3QVF7
names: Similarity
messages: Belongs to the PAL/histidase family.

9595:MMP3
gene id: 9595:MMP3
uniprot id: G3R469
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:DUSP3
gene id: 9595:DUSP3
uniprot id: G3SGS9
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9595:DNAJC22
gene id: 9595:DNAJC22
uniprot id: G3SJ05
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9595:AFG1L
gene id: 9595:AFG1L
uniprot id: G3QNP4
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9595:LSS
gene id: 9595:LSS
uniprot id: G3RI42
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

9595:PKIA
gene id: 9595:PKIA
uniprot id: G3RTH0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:DYNLRB1
gene id: 9595:DYNLRB1
uniprot id: G3SAD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9595:BLCAP
gene id: 9595:BLCAP
uniprot id: G3S7R5
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9595:JARID2
gene id: 9595:JARID2
uniprot id: A0A2I2Y3Q1
uniprot id: G3QS10
names: Subcellular Location Annotation
messages: Nucleus

9595:DIMT1
gene id: 9595:DIMT1
uniprot id: G3QIQ8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9595:MYF5
gene id: 9595:MYF5
uniprot id: G3QNZ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9595:LOC101140641
gene id: 9595:LOC101140641
uniprot id: G3R516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9595:PFDN1
gene id: 9595:PFDN1
uniprot id: A0A2I2ZB60
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9595:KLHL15
gene id: 9595:KLHL15
uniprot id: G3S6V6
names: Subcellular Location Annotation
messages: Nucleus

9595:HS6ST1
gene id: 9595:HS6ST1
uniprot id: A0A2I2YYD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9595:ASPH
gene id: 9595:ASPH
uniprot id: A0A2I2YKA1
uniprot id: A0A2I2ZY46
uniprot id: G3R0I3
uniprot id: G3S8Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9595:YWHAH
gene id: 9595:YWHAH
uniprot id: G3QTE1
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:PACSIN2
gene id: 9595:PACSIN2
uniprot id: G3RJL7
uniprot id: G3SBB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9595:GK
gene id: 9595:GK
uniprot id: A0A2I2Z5A3
uniprot id: A0A2I2ZJI3
uniprot id: A0A2I2ZR50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9595:RBM10
gene id: 9595:RBM10
uniprot id: G3QXY4
names: Subcellular Location Annotation
messages: Nucleus

9595:MTF2
gene id: 9595:MTF2
uniprot id: G3QG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9595:TMEM53
gene id: 9595:TMEM53
uniprot id: G3QE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9595:P2RY13
gene id: 9595:P2RY13
uniprot id: G3REZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ERMN
gene id: 9595:ERMN
uniprot id: G3R383
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9595:UBAC2
gene id: 9595:UBAC2
uniprot id: G3SKK0
names: Subcellular Location Annotation
messages: Membrane

9595:TOE1
gene id: 9595:TOE1
uniprot id: G3QL86
names: Similarity
messages: Belongs to the CAF1 family.

9595:FLI1
gene id: 9595:FLI1
uniprot id: A0A2I2ZEQ5
uniprot id: G3QDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:CRHR1
gene id: 9595:CRHR1
uniprot id: G3RR87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

9595:CDKN3
gene id: 9595:CDKN3
uniprot id: A0A2I2ZBS0
uniprot id: A0A2I2ZUL2
uniprot id: G3QSG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9595:BUD31
gene id: 9595:BUD31
uniprot id: G3RGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9595:NAMPT
gene id: 9595:NAMPT
uniprot id: A0A2I2Z4X6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9595:SF3B4
gene id: 9595:SF3B4
uniprot id: G3QQ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9595:ZNF408
gene id: 9595:ZNF408
uniprot id: G3R3S5
names: Subcellular Location Annotation
messages: Nucleus

9595:CFAP97D1
gene id: 9595:CFAP97D1
uniprot id: G3RN08
names: Similarity
messages: Belongs to the CFAP97 family.

9595:LECT2
gene id: 9595:LECT2
uniprot id: G3S367
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9595:MRPL14
gene id: 9595:MRPL14
uniprot id: G3QTE8
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9595:MYO1G
gene id: 9595:MYO1G
uniprot id: G3R5P5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:MYO18A
gene id: 9595:MYO18A
uniprot id: A0A2I2YUD7
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HPGD
gene id: 9595:HPGD
uniprot id: G3R336
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:WASF2
gene id: 9595:WASF2
uniprot id: G3RPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:TH
gene id: 9595:TH
uniprot id: A0A2I2Z4B3
uniprot id: G3QN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9595:TTC26
gene id: 9595:TTC26
uniprot id: G3QSE7
names: Similarity
messages: Belongs to the IFT56 family.

9595:DOCK1
gene id: 9595:DOCK1
uniprot id: G3RGJ8
names: Similarity
messages: Belongs to the DOCK family.

9595:KCNV2
gene id: 9595:KCNV2
uniprot id: G3QDB6
names: Subcellular Location Annotation
messages: Membrane

9595:FAM24A
gene id: 9595:FAM24A
uniprot id: G3QW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

9595:PTGS2
gene id: 9595:PTGS2
uniprot id: G3RPV2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane

9595:MON2
gene id: 9595:MON2
uniprot id: A0A2I2YQA5
uniprot id: G3R8U3
uniprot id: G3SEK7
names: Similarity
messages: Belongs to the MON2 family.

9595:SNX25
gene id: 9595:SNX25
uniprot id: G3RLT7
names: Similarity
messages: Belongs to the sorting nexin family.

9595:SCN9A
gene id: 9595:SCN9A
uniprot id: G3SCI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:MDM4
gene id: 9595:MDM4
uniprot id: G3RB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9595:GRHPR
gene id: 9595:GRHPR
uniprot id: G3QMB0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9595:TAF1A
gene id: 9595:TAF1A
uniprot id: G3QFT8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9595:CASKIN2
gene id: 9595:CASKIN2
uniprot id: G3R1W4
names: Subcellular Location Annotation
messages: Cytoplasm

9595:KEG83 p10
gene id: 9595:KEG83_p10
uniprot id: G3RYU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9595:LOC101152412
gene id: 9595:LOC101152412
uniprot id: Q0ZQL0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: Secreted

9595:FOLR1
gene id: 9595:FOLR1
uniprot id: G3QS30
names: Similarity
messages: Belongs to the folate receptor family.

9595:MTMR11
gene id: 9595:MTMR11
uniprot id: G3QQ15
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9595:TCIRG1
gene id: 9595:TCIRG1
uniprot id: G3QQP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9595:DEFA1B
gene id: 9595:DEFA1B
uniprot id: G3QPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9595:OSTC
gene id: 9595:OSTC
uniprot id: G3RSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9595:NSMCE1
gene id: 9595:NSMCE1
uniprot id: G3QUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9595:ST8SIA5
gene id: 9595:ST8SIA5
uniprot id: G3RD61
uniprot id: G3S807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:VAX2
gene id: 9595:VAX2
uniprot id: G3QWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9595:ZSCAN18
gene id: 9595:ZSCAN18
uniprot id: G3RYM1
names: Subcellular Location Annotation
messages: Nucleus

9595:DDIT4
gene id: 9595:DDIT4
uniprot id: G3QJW5
names: Similarity
messages: Belongs to the DDIT4 family.

9595:POU2F1
gene id: 9595:POU2F1
uniprot id: A0A2I2YMW8
uniprot id: G3RJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9595:CDC37
gene id: 9595:CDC37
uniprot id: G3S245
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9595:SLC12A3
gene id: 9595:SLC12A3
uniprot id: G3R3N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:GSDMA
gene id: 9595:GSDMA
uniprot id: G3QQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9595:LOC101147473
gene id: 9595:LOC101147473
uniprot id: A0A2I2YW10
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:ALG5
gene id: 9595:ALG5
uniprot id: G3QKR3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9595:VTI1A
gene id: 9595:VTI1A
uniprot id: A0A2I2ZMC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9595:NME3
gene id: 9595:NME3
uniprot id: G3QTR3
names: Similarity
messages: Belongs to the NDK family.

9595:VPS52
gene id: 9595:VPS52
uniprot id: G3QUM2
names: Similarity
messages: Belongs to the VPS52 family.

9595:LOC101149308
gene id: 9595:LOC101149308
uniprot id: G3QI10
names: Subcellular Location Annotation
messages: Membrane

9595:TRAM1L1
gene id: 9595:TRAM1L1
uniprot id: G3QD22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9595:NDUFS8
gene id: 9595:NDUFS8
uniprot id: Q0MQI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9595:NBR1
gene id: 9595:NBR1
uniprot id: A0A2I2YAA1
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9595:HEXIM2
gene id: 9595:HEXIM2
uniprot id: A0A2I2Z8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9595:NDUFB5
gene id: 9595:NDUFB5
uniprot id: A0A2I2YPV4
uniprot id: A0A2I2ZAF4
uniprot id: Q0MQD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:GSTT2B
gene id: 9595:GSTT2B
uniprot id: G3R050
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9595:SLC45A3
gene id: 9595:SLC45A3
uniprot id: G3QUX3
names: Subcellular Location Annotation
messages: Membrane

9595:OAF
gene id: 9595:OAF
uniprot id: G3R041
names: Similarity
messages: Belongs to the OAF family.

9595:LOC101141699
gene id: 9595:LOC101141699
uniprot id: G3QIY6
names: Subcellular Location Annotation
messages: Membrane

9595:POLD3
gene id: 9595:POLD3
uniprot id: G3RAT6
names: Subcellular Location Annotation
messages: Nucleus

9595:TTC3
gene id: 9595:TTC3
uniprot id: A0A2I2YT81
names: Subcellular Location Annotation
messages: Cytoplasm

9595:RPS12
gene id: 9595:RPS12
uniprot id: G3R953
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9595:PSIP1
gene id: 9595:PSIP1
uniprot id: G3RJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9595:NUBP1
gene id: 9595:NUBP1
uniprot id: A0A2I2YWT3
uniprot id: G3QF82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9595:SLC22A4
gene id: 9595:SLC22A4
uniprot id: G3R4H4
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9595:OPRPN
gene id: 9595:OPRPN
uniprot id: G3R6J8
names: Subcellular Location Annotation
messages: Secreted

9595:A3GALT2
gene id: 9595:A3GALT2
uniprot id: G3QM07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9595:ZNF496
gene id: 9595:ZNF496
uniprot id: G3RYY8
names: Subcellular Location Annotation
messages: Nucleus

9595:ADGRA3
gene id: 9595:ADGRA3
uniprot id: G3SEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9595:DZIP3
gene id: 9595:DZIP3
uniprot id: A0A2I2YK06
names: Subcellular Location Annotation
messages: Cytoplasm

9595:FAM49B
gene id: 9595:FAM49B
uniprot id: G3SFG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9595:HOXD1
gene id: 9595:HOXD1
uniprot id: G3S0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9595:SESN1
gene id: 9595:SESN1
uniprot id: A0A2I2YZC4
uniprot id: G3QYS2
uniprot id: G3RU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9595:NPLOC4
gene id: 9595:NPLOC4
uniprot id: G3SGZ9
names: Similarity
messages: Belongs to the NPL4 family.

9595:PRM2
gene id: 9595:PRM2
uniprot id: G3QEH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9595:YOD1
gene id: 9595:YOD1
uniprot id: A0A2I2YDR5
uniprot id: G3QU72
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9595:RPL9
gene id: 9595:RPL9
uniprot id: G3SHM1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9595:IMPDH1
gene id: 9595:IMPDH1
uniprot id: G3QMZ1
uniprot id: G3RZ87
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9595:TGS1
gene id: 9595:TGS1
uniprot id: G3QZW2
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9595:COPB1
gene id: 9595:COPB1
uniprot id: G3S1L5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9595:GNAI3
gene id: 9595:GNAI3
uniprot id: G3SCU6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:NAPG
gene id: 9595:NAPG
uniprot id: G3RHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9595:RDH10
gene id: 9595:RDH10
uniprot id: A0A2I2Y821
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9595:MYBL2
gene id: 9595:MYBL2
uniprot id: G3RMI6
names: Subcellular Location Annotation
messages: Nucleus

9595:MRFAP1L1
gene id: 9595:MRFAP1L1
uniprot id: G3RMU4
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9595:LOC109026990
gene id: 9595:LOC109026990
uniprot id: G3QK54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9595:LOC101125514
gene id: 9595:LOC101125514
uniprot id: G3QVM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SOST
gene id: 9595:SOST
uniprot id: G3QKL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

9595:PLCZ1
gene id: 9595:PLCZ1
uniprot id: A0A2I2ZNM2
names: Function
names: Subcellular Location Annotation
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9595:LOC101150279
gene id: 9595:LOC101150279
uniprot id: A0A2I2YGV9
uniprot id: A0A2I2ZY13
uniprot id: G3SDI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:GALR1
gene id: 9595:GALR1
uniprot id: G3QG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:MST1
gene id: 9595:MST1
uniprot id: G3R4W6
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MRPL2
gene id: 9595:MRPL2
uniprot id: G3R4S7
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9595:THOC5
gene id: 9595:THOC5
uniprot id: A0A2I2YMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9595:TMA16
gene id: 9595:TMA16
uniprot id: G3RQG7
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9595:HPCAL4
gene id: 9595:HPCAL4
uniprot id: A0A2I2ZD66
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9595:MAT2A
gene id: 9595:MAT2A
uniprot id: G3QQH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9595:GOT1L1
gene id: 9595:GOT1L1
uniprot id: G3RE96
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9595:KIFC3
gene id: 9595:KIFC3
uniprot id: G3QW48
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:DPPA2
gene id: 9595:DPPA2
uniprot id: A0A2I2ZN25
names: Subcellular Location Annotation
messages: Nucleus

9595:POPDC2
gene id: 9595:POPDC2
uniprot id: G3QNZ3
names: Similarity
messages: Belongs to the popeye family.

9595:RPS6KA2
gene id: 9595:RPS6KA2
uniprot id: A0A2I2YBD0
uniprot id: A0A2I2YGP7
uniprot id: G3SHK7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:LCAT
gene id: 9595:LCAT
uniprot id: G3QQL2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:IFT20
gene id: 9595:IFT20
uniprot id: A0A2I2Y652
uniprot id: A0A2I2ZW01
uniprot id: G3QPI3
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9595:DMRTB1
gene id: 9595:DMRTB1
uniprot id: G3S787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:CALR3
gene id: 9595:CALR3
uniprot id: G3SIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9595:DGKA
gene id: 9595:DGKA
uniprot id: G3RDT9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9595:APMAP
gene id: 9595:APMAP
uniprot id: G3QG13
names: Similarity
messages: Belongs to the strictosidine synthase family.

9595:CCDC22
gene id: 9595:CCDC22
uniprot id: G3QF36
names: Similarity
messages: Belongs to the CCDC22 family.

9595:GPR61
gene id: 9595:GPR61
uniprot id: G3RDT0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DLGAP4
gene id: 9595:DLGAP4
uniprot id: A0A2I2Z3I1
uniprot id: A0A2I2ZBH1
uniprot id: G3QRS7
uniprot id: G3QXA3
names: Similarity
messages: Belongs to the SAPAP family.

9595:LMNB1
gene id: 9595:LMNB1
uniprot id: G3RWL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9595:BABAM1
gene id: 9595:BABAM1
uniprot id: G3QSM0
uniprot id: G3S649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9595:VEPH1
gene id: 9595:VEPH1
uniprot id: G3SKM2
names: Similarity
messages: Belongs to the MELT/VEPH family.

9595:FRZB
gene id: 9595:FRZB
uniprot id: G3QSJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9595:TNFRSF1A
gene id: 9595:TNFRSF1A
uniprot id: G3SG18
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:FLNA
gene id: 9595:FLNA
uniprot id: A0A2I2YQV4
uniprot id: G3QNL9
names: Similarity
messages: Belongs to the filamin family.

9595:STXBP5L
gene id: 9595:STXBP5L
uniprot id: A0A2I2ZJA0
uniprot id: G3SKU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:TGM5
gene id: 9595:TGM5
uniprot id: A0A2I2ZV85
uniprot id: G3QUL1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:NSDHL
gene id: 9595:NSDHL
uniprot id: G3RLK2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9595:LOC101133112
gene id: 9595:LOC101133112
uniprot id: G3REG1
names: Subcellular Location Annotation
messages: Membrane

9595:AGBL1
gene id: 9595:AGBL1
uniprot id: G3SKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9595:ATRNL1
gene id: 9595:ATRNL1
uniprot id: G3SGZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:UPK1B
gene id: 9595:UPK1B
uniprot id: G3R766
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9595:MUL1
gene id: 9595:MUL1
uniprot id: G3QUY4
names: Subcellular Location Annotation
messages: Membrane

9595:PA2G4
gene id: 9595:PA2G4
uniprot id: A0A2I2YMZ4
names: Similarity
messages: Belongs to the peptidase M24 family.

9595:FGF23
gene id: 9595:FGF23
uniprot id: G3QKE3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:DEFB1
gene id: 9595:DEFB1
uniprot id: Q95M68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9595:RTBDN
gene id: 9595:RTBDN
uniprot id: G3QHP1
names: Similarity
messages: Belongs to the folate receptor family.

9595:NPBWR1
gene id: 9595:NPBWR1
uniprot id: G3RGV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101151730
gene id: 9595:LOC101151730
uniprot id: A0A2I2ZE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:GTF2F2
gene id: 9595:GTF2F2
uniprot id: G3QUV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9595:KCNE4
gene id: 9595:KCNE4
uniprot id: G3RLT2
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9595:TWF1
gene id: 9595:TWF1
uniprot id: G3QSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9595:EIF3M
gene id: 9595:EIF3M
uniprot id: A0A2I2ZIS0
uniprot id: G3QJZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101147119
gene id: 9595:LOC101147119
uniprot id: G3SEK6
names: Subcellular Location Annotation
messages: Nucleus

9595:EGFL6
gene id: 9595:EGFL6
uniprot id: G3RAM1
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MBTD1
gene id: 9595:MBTD1
uniprot id: G3SJ72
names: Subcellular Location Annotation
messages: Nucleus

9595:SF3A1
gene id: 9595:SF3A1
uniprot id: G3RA68
names: Subcellular Location Annotation
messages: Nucleus

9595:CD99
gene id: 9595:CD99
uniprot id: A0A2I2ZSI6
uniprot id: G3R4R1
names: Similarity
messages: Belongs to the CD99 family.

9595:HCN3
gene id: 9595:HCN3
uniprot id: G3RJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9595:TM9SF4
gene id: 9595:TM9SF4
uniprot id: G3R4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9595:ITGB3
gene id: 9595:ITGB3
uniprot id: A0A2I2ZY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9595:GREM1
gene id: 9595:GREM1
uniprot id: G3S6C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9595:ANXA13
gene id: 9595:ANXA13
uniprot id: G3QYM5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:GUK1
gene id: 9595:GUK1
uniprot id: A0A2I2YN43
uniprot id: G3RCK1
uniprot id: G3S7U3
names: Similarity
messages: Belongs to the guanylate kinase family.

9595:LOC109025285
gene id: 9595:LOC109025285
uniprot id: A0A2I2Z627
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9595:EYA1
gene id: 9595:EYA1
uniprot id: G3QL19
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9595:RPS5
gene id: 9595:RPS5
uniprot id: A0A2I2Z9R5
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9595:SERINC2
gene id: 9595:SERINC2
uniprot id: G3QYU9
uniprot id: G3RMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:SLFN13
gene id: 9595:SLFN13
uniprot id: G3REF2
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9595:SPEM2
gene id: 9595:SPEM2
uniprot id: G3R821
names: Subcellular Location Annotation
messages: Membrane

9595:SYS1
gene id: 9595:SYS1
uniprot id: G3QNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9595:LIPT1
gene id: 9595:LIPT1
uniprot id: G3S0M5
names: Similarity
messages: Belongs to the LplA family.

9595:GORASP2
gene id: 9595:GORASP2
uniprot id: G3R9Y6
names: Similarity
messages: Belongs to the GORASP family.

9595:HOXA2
gene id: 9595:HOXA2
uniprot id: G3QIG7
names: Subcellular Location Annotation
messages: Nucleus

9595:PPM1A
gene id: 9595:PPM1A
uniprot id: G3R3K7
uniprot id: G3SHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9595:NEK9
gene id: 9595:NEK9
uniprot id: G3S0W8
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9595:RASGRP2
gene id: 9595:RASGRP2
uniprot id: A0A2I2YWI9
uniprot id: G3RAC5
names: Similarity
messages: Belongs to the RASGRP family.

9595:TOR2A
gene id: 9595:TOR2A
uniprot id: A0A2I2Y268
uniprot id: G3R628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9595:TRPC6
gene id: 9595:TRPC6
uniprot id: A0A2I2ZFZ7
uniprot id: G3R1D4
uniprot id: G3S288
names: Subcellular Location Annotation
messages: Membrane

9595:LOC109024295
gene id: 9595:LOC109024295
uniprot id: G3S6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:UPP1
gene id: 9595:UPP1
uniprot id: G3RQE9
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9595:PON2
gene id: 9595:PON2
uniprot id: G3RXU5
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9595:PARVG
gene id: 9595:PARVG
uniprot id: G3RK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9595:LOC101141508
gene id: 9595:LOC101141508
uniprot id: G3R2E6
names: Similarity
messages: Belongs to the SKP1 family.

9595:PRRC1
gene id: 9595:PRRC1
uniprot id: A0A2I2Z4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9595:IMP4
gene id: 9595:IMP4
uniprot id: G3QGV6
names: Subcellular Location Annotation
messages: nucleolus

9595:GGA2
gene id: 9595:GGA2
uniprot id: G3SFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9595:HEBP2
gene id: 9595:HEBP2
uniprot id: G3QGU6
names: Similarity
messages: Belongs to the HEBP family.

9595:FAM172A
gene id: 9595:FAM172A
uniprot id: A0A2I2Z2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

9595:ATP2B2
gene id: 9595:ATP2B2
uniprot id: A0A2I2Y5B8
uniprot id: G3R3U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LTBP1
gene id: 9595:LTBP1
uniprot id: A0A2I2ZQF7
uniprot id: G3R903
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:MARF1
gene id: 9595:MARF1
uniprot id: G3R0R4
names: Subcellular Location Annotation
messages: Peroxisome

9595:SPON2
gene id: 9595:SPON2
uniprot id: G3QJR7
names: Subcellular Location Annotation
messages: extracellular matrix

9595:SPIN4
gene id: 9595:SPIN4
uniprot id: G3QJS7
names: Similarity
messages: Belongs to the SPIN/STSY family.

9595:HDC
gene id: 9595:HDC
uniprot id: A0A2I2YH58
uniprot id: G3S6Z9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:AADACL2
gene id: 9595:AADACL2
uniprot id: G3R0M5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9595:SETD2
gene id: 9595:SETD2
uniprot id: A0A2I2Z1X0
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:ANXA3
gene id: 9595:ANXA3
uniprot id: G3SEL8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:OPA1
gene id: 9595:OPA1
uniprot id: A0A2I2Y2W8
uniprot id: A0A2I2Y7Q2
uniprot id: G3S1U3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9595:COPS6
gene id: 9595:COPS6
uniprot id: G3QJT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9595:SCN3B
gene id: 9595:SCN3B
uniprot id: G3QXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9595:PRDX1
gene id: 9595:PRDX1
uniprot id: A0A2I2ZDQ0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9595:SLC35A2
gene id: 9595:SLC35A2
uniprot id: A0A2I2Y8V7
uniprot id: A0A2I2ZMW6
uniprot id: G3S1I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9595:TOMM7
gene id: 9595:TOMM7
uniprot id: A0A2I2Y7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:VPS4B
gene id: 9595:VPS4B
uniprot id: G3QV21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:PEX19
gene id: 9595:PEX19
uniprot id: G3S3F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9595:CNNM1
gene id: 9595:CNNM1
uniprot id: G3QJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9595:LOC101131404
gene id: 9595:LOC101131404
uniprot id: G3QEZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9595:INTS14
gene id: 9595:INTS14
uniprot id: A0A2I2YSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9595:DESI2
gene id: 9595:DESI2
uniprot id: G3R2V6
names: Similarity
messages: Belongs to the DeSI family.

9595:FLVCR1
gene id: 9595:FLVCR1
uniprot id: G3QH88
names: Subcellular Location Annotation
messages: Membrane

9595:ZSCAN22
gene id: 9595:ZSCAN22
uniprot id: A0A2I2ZSX9
names: Subcellular Location Annotation
messages: Nucleus

9595:DBNDD1
gene id: 9595:DBNDD1
uniprot id: A0A2I2Y6M9
names: Similarity
messages: Belongs to the dysbindin family.

9595:IFI27
gene id: 9595:IFI27
uniprot id: G3QV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:C16H16orf72
gene id: 9595:C16H16orf72
uniprot id: G3R5A4
names: Similarity
messages: Belongs to the TAPR1 family.

9595:NELFE
gene id: 9595:NELFE
uniprot id: G3QIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9595:AKAP12
gene id: 9595:AKAP12
uniprot id: A0A2I2Y3L9
uniprot id: A0A2I2ZCZ8
uniprot id: G3RQR0
names: Subcellular Location Annotation
messages: Membrane

9595:TPD52L1
gene id: 9595:TPD52L1
uniprot id: A0A2I2Y4Z3
uniprot id: A0A2I2YHZ0
uniprot id: A0A2I2YPJ0
uniprot id: A0A2I2Z8J6
uniprot id: A0A2I2ZCI0
uniprot id: G3QQ90
names: Similarity
messages: Belongs to the TPD52 family.

9595:EZH2
gene id: 9595:EZH2
uniprot id: G3S979
names: Subcellular Location Annotation
messages: Nucleus

9595:ORC5
gene id: 9595:ORC5
uniprot id: G3QFC8
names: Subcellular Location Annotation
messages: Nucleus

9595:CDC42EP2
gene id: 9595:CDC42EP2
uniprot id: A0A2I2ZUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9595:ELK4
gene id: 9595:ELK4
uniprot id: G3RX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:MAP1LC3C
gene id: 9595:MAP1LC3C
uniprot id: G3QDD6
names: Similarity
messages: Belongs to the ATG8 family.

9595:LOC101153072
gene id: 9595:LOC101153072
uniprot id: G3R2D5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:HNRNPC
gene id: 9595:HNRNPC
uniprot id: A0A2I2ZKV1
uniprot id: A0A2I2ZNA6
uniprot id: G3S5X7
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:HHATL
gene id: 9595:HHATL
uniprot id: G3QVU8
names: Subcellular Location Annotation
messages: Membrane

9595:LMX1A
gene id: 9595:LMX1A
uniprot id: G3QL82
names: Subcellular Location Annotation
messages: Nucleus

9595:RALY
gene id: 9595:RALY
uniprot id: G3S2S1
uniprot id: G3SGA9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:RPL37A
gene id: 9595:RPL37A
uniprot id: G3RFT4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9595:SEMA3D
gene id: 9595:SEMA3D
uniprot id: G3RA65
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC25A15
gene id: 9595:SLC25A15
uniprot id: G3S1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:HS2ST1
gene id: 9595:HS2ST1
uniprot id: A0A2I2YUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9595:NUP205
gene id: 9595:NUP205
uniprot id: G3R7B7
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9595:TRAF4
gene id: 9595:TRAF4
uniprot id: G3RKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9595:NCOA1
gene id: 9595:NCOA1
uniprot id: G3R6P2
uniprot id: G3RV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9595:LOC101149484
gene id: 9595:LOC101149484
uniprot id: G3RGC9
names: Similarity
messages: Belongs to the cytochrome b5 family.

9595:MTRNR2L4
gene id: 9595:MTRNR2L4
uniprot id: A0A2I2YAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the humanin family.
messages: Secreted

9595:CDH19
gene id: 9595:CDH19
uniprot id: G3S948
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:KCNG1
gene id: 9595:KCNG1
uniprot id: G3QEX6
names: Subcellular Location Annotation
messages: Membrane

9595:TAPT1
gene id: 9595:TAPT1
uniprot id: G3R827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9595:EBAG9
gene id: 9595:EBAG9
uniprot id: G3SGS2
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9595:LPGAT1
gene id: 9595:LPGAT1
uniprot id: A0A2I2Z0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:GALC
gene id: 9595:GALC
uniprot id: G3RPY6
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

9595:ATP13A4
gene id: 9595:ATP13A4
uniprot id: G3QVX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9595:IL1B
gene id: 9595:IL1B
uniprot id: G3QU53
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9595:SERPINI2
gene id: 9595:SERPINI2
uniprot id: G3R4R7
names: Similarity
messages: Belongs to the serpin family.

9595:IGFBP4
gene id: 9595:IGFBP4
uniprot id: G3R338
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:AWAT2
gene id: 9595:AWAT2
uniprot id: G3QSZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9595:MOGS
gene id: 9595:MOGS
uniprot id: A0A2I2YD12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9595:SPATA6
gene id: 9595:SPATA6
uniprot id: A0A2I2YIE2
names: Similarity
messages: Belongs to the SPATA6 family.

9595:CDCA5
gene id: 9595:CDCA5
uniprot id: A0A2I2YL62
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:LOC101137932
gene id: 9595:LOC101137932
uniprot id: G3QDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:LTA4H
gene id: 9595:LTA4H
uniprot id: G3QVH4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9595:ACOT8
gene id: 9595:ACOT8
uniprot id: G3QKM8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9595:BRINP3
gene id: 9595:BRINP3
uniprot id: G3QZJ0
names: Similarity
messages: Belongs to the BRINP family.

9595:SDHB
gene id: 9595:SDHB
uniprot id: G3RJI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9595:NUMB
gene id: 9595:NUMB
uniprot id: A0A2I2YDF7
uniprot id: A0A2I2ZY37
uniprot id: G3QIA3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9595:GAD1
gene id: 9595:GAD1
uniprot id: A0A2I2ZG24
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:SASS6
gene id: 9595:SASS6
uniprot id: G3QF34
names: Subcellular Location Annotation
messages: centrosome

9595:LOC101133052
gene id: 9595:LOC101133052
uniprot id: G3RPG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:COG3
gene id: 9595:COG3
uniprot id: G3QT79
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9595:TUBB8
gene id: 9595:TUBB8
uniprot id: A0A2I2ZJA6
uniprot id: G3S4L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:P3H2
gene id: 9595:P3H2
uniprot id: G3R2R6
names: Similarity
messages: Belongs to the leprecan family.

9595:SUGP1
gene id: 9595:SUGP1
uniprot id: G3QKG2
names: Subcellular Location Annotation
messages: Nucleus

9595:GALNT15
gene id: 9595:GALNT15
uniprot id: A0A2I2Z158
uniprot id: G3R1J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:MYO5C
gene id: 9595:MYO5C
uniprot id: G3RCG3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:SLC2A6
gene id: 9595:SLC2A6
uniprot id: G3RA13
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9595:NUP133
gene id: 9595:NUP133
uniprot id: G3S1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9595:GTF2A1
gene id: 9595:GTF2A1
uniprot id: A0A2I2YC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9595:CAPG
gene id: 9595:CAPG
uniprot id: G3R7I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9595:GSTA4
gene id: 9595:GSTA4
uniprot id: G3QRL1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9595:ABHD16A
gene id: 9595:ABHD16A
uniprot id: A0A2I2ZIB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9595:PIGK
gene id: 9595:PIGK
uniprot id: G3R1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9595:LACTB2
gene id: 9595:LACTB2
uniprot id: G3SGF8
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9595:RPS6KA5
gene id: 9595:RPS6KA5
uniprot id: G3QNQ7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:PPIH
gene id: 9595:PPIH
uniprot id: A0A2I2ZYC9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:TLR8
gene id: 9595:TLR8
uniprot id: G3R9E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9595:BGLAP
gene id: 9595:BGLAP
uniprot id: P84349
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9595:NR1D1
gene id: 9595:NR1D1
uniprot id: G3R2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:MRPL35
gene id: 9595:MRPL35
uniprot id: G3SB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9595:PCMTD1
gene id: 9595:PCMTD1
uniprot id: A0A2I2YGW6
uniprot id: G3S020
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9595:ARF5
gene id: 9595:ARF5
uniprot id: G3RKR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9595:INSL4
gene id: 9595:INSL4
uniprot id: G3RYG6
names: Subcellular Location Annotation
messages: Secreted

9595:PPARA
gene id: 9595:PPARA
uniprot id: A0A2I2Z0P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9595:AGA
gene id: 9595:AGA
uniprot id: G3QX96
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9595:HSD17B3
gene id: 9595:HSD17B3
uniprot id: G3QK20
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:FPR1
gene id: 9595:FPR1
uniprot id: G3QRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RYR3
gene id: 9595:RYR3
uniprot id: A0A2I2YLG9
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9595:ARID5B
gene id: 9595:ARID5B
uniprot id: A0A2I2Z1S3
uniprot id: G3QND9
names: Similarity
messages: Belongs to the ARID5B family.

9595:MCOLN1
gene id: 9595:MCOLN1
uniprot id: G3R518
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:FOXB2
gene id: 9595:FOXB2
uniprot id: A0A2I2ZRB3
names: Subcellular Location Annotation
messages: Nucleus

9595:PLSCR2
gene id: 9595:PLSCR2
uniprot id: G3R3Q8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9595:LOC109023055
gene id: 9595:LOC109023055
uniprot id: G3RIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9595:TMEM167A
gene id: 9595:TMEM167A
uniprot id: A0A2I2YI11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9595:TPM1
gene id: 9595:TPM1
uniprot id: A0A2I2YHE5
uniprot id: A0A2I2ZAB7
uniprot id: A0A2I2ZKG9
uniprot id: G3R169
uniprot id: G3RWR8
uniprot id: G3S1U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9595:LOC101150648
gene id: 9595:LOC101150648
uniprot id: G3RSQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101148343
gene id: 9595:LOC101148343
uniprot id: G3S0S4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:MRPS9
gene id: 9595:MRPS9
uniprot id: G3QXN0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9595:ALX4
gene id: 9595:ALX4
uniprot id: G3RED1
names: Subcellular Location Annotation
messages: Nucleus

9595:FMNL3
gene id: 9595:FMNL3
uniprot id: A0A2I2YRC4
uniprot id: G3QGU8
names: Similarity
messages: Belongs to the formin homology family.

9595:IRX6
gene id: 9595:IRX6
uniprot id: G3SBL6
names: Subcellular Location Annotation
messages: Nucleus

9595:KIF17
gene id: 9595:KIF17
uniprot id: G3RF78
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:MKS1
gene id: 9595:MKS1
uniprot id: A0A2I2YI77
uniprot id: G3QKV3
names: Subcellular Location Annotation
messages: cilium basal body

9595:CNP
gene id: 9595:CNP
uniprot id: A0A2I2ZL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9595:RRP36
gene id: 9595:RRP36
uniprot id: G3QWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9595:CAPN9
gene id: 9595:CAPN9
uniprot id: A0A2I2ZVF1
uniprot id: A0A2I2ZY47
uniprot id: G3RAS2
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MRPS31
gene id: 9595:MRPS31
uniprot id: G3QUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9595:CLDN18
gene id: 9595:CLDN18
uniprot id: G3RCR4
uniprot id: G3S9A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:PKN2
gene id: 9595:PKN2
uniprot id: A0A2I2Z7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9595:TMPRSS11F
gene id: 9595:TMPRSS11F
uniprot id: G3QFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9595:THUMPD3
gene id: 9595:THUMPD3
uniprot id: G3QEA2
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9595:LOC101138570
gene id: 9595:LOC101138570
uniprot id: G3R0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9595:IQCD
gene id: 9595:IQCD
uniprot id: G3RNN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9595:MBTPS2
gene id: 9595:MBTPS2
uniprot id: G3R8Q6
names: Similarity
messages: Belongs to the peptidase M50A family.

9595:ATP5PB
gene id: 9595:ATP5PB
uniprot id: G3QR73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9595:HNRNPUL2
gene id: 9595:HNRNPUL2
uniprot id: G3R7T9
names: Subcellular Location Annotation
messages: Nucleus

9595:MLNR
gene id: 9595:MLNR
uniprot id: G3QMK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:YWHAG
gene id: 9595:YWHAG
uniprot id: G3S848
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:ARHGAP26
gene id: 9595:ARHGAP26
uniprot id: G3QVT9
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9595:SLC39A1
gene id: 9595:SLC39A1
uniprot id: A0A2I2YJF2
names: Subcellular Location Annotation
messages: Membrane

9595:SEMA3C
gene id: 9595:SEMA3C
uniprot id: G3RJN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SERPINB6
gene id: 9595:SERPINB6
uniprot id: A0A2I2Z2G9
uniprot id: G3R677
names: Similarity
messages: Belongs to the serpin family.

9595:NIFK
gene id: 9595:NIFK
uniprot id: G3RQP7
names: Subcellular Location Annotation
messages: nucleolus

9595:IL2
gene id: 9595:IL2
uniprot id: G3S1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9595:KCNK18
gene id: 9595:KCNK18
uniprot id: G3SCI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:ICAM1
gene id: 9595:ICAM1
uniprot id: Q5NKV9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
messages: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
messages: Membrane
messages: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

9595:ERMAP
gene id: 9595:ERMAP
uniprot id: G3QWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9595:PFDN4
gene id: 9595:PFDN4
uniprot id: G3SA67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9595:HUS1
gene id: 9595:HUS1
uniprot id: G3QEC0
names: Similarity
messages: Belongs to the HUS1 family.

9595:CRTC2
gene id: 9595:CRTC2
uniprot id: G3S1G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9595:CDIP1
gene id: 9595:CDIP1
uniprot id: G3S7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9595:GPR31
gene id: 9595:GPR31
uniprot id: G3QWQ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:MIEF2
gene id: 9595:MIEF2
uniprot id: G3SF57
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:PEPD
gene id: 9595:PEPD
uniprot id: G3R8Y2
names: Similarity
messages: Belongs to the peptidase M24B family.

9595:OCIAD1
gene id: 9595:OCIAD1
uniprot id: G3QUW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9595:FABP1
gene id: 9595:FABP1
uniprot id: G3R258
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9595:BLOC1S1
gene id: 9595:BLOC1S1
uniprot id: G3QKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9595:DDX58
gene id: 9595:DDX58
uniprot id: G3S7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9595:EXOC6B
gene id: 9595:EXOC6B
uniprot id: A0A2I2YNU2
uniprot id: G3QDX8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9595:OTUB2
gene id: 9595:OTUB2
uniprot id: G3QV24
names: Similarity
messages: Belongs to the peptidase C65 family.

9595:AARSD1
gene id: 9595:AARSD1
uniprot id: G3SH26
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9595:LNPEP
gene id: 9595:LNPEP
uniprot id: A0A2I2ZXA2
names: Similarity
messages: Belongs to the peptidase M1 family.

9595:CEBPZ
gene id: 9595:CEBPZ
uniprot id: A0A2I2YFX5
uniprot id: G3R6U5
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9595:RNF111
gene id: 9595:RNF111
uniprot id: A0A2I2ZY67
uniprot id: G3RLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9595:CLEC18B
gene id: 9595:CLEC18B
uniprot id: G3S2V5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ACKR1
gene id: 9595:ACKR1
uniprot id: Q95LF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9595:ELF2
gene id: 9595:ELF2
uniprot id: A0A2I2YZF6
uniprot id: G3RIQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:PEX2
gene id: 9595:PEX2
uniprot id: A0A2I2Z8W1
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9595:SYN3
gene id: 9595:SYN3
uniprot id: A0A2I2Y534
names: Similarity
messages: Belongs to the synapsin family.

9595:MARK2
gene id: 9595:MARK2
uniprot id: A0A2I2Y6Q3
uniprot id: A0A2I2ZW92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:BCL2L14
gene id: 9595:BCL2L14
uniprot id: G3RAG8
names: Similarity
messages: Belongs to the Bcl-2 family.

9595:GTF2E1
gene id: 9595:GTF2E1
uniprot id: G3S0U4
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9595:IQCG
gene id: 9595:IQCG
uniprot id: A0A2I2Z7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9595:SQSTM1
gene id: 9595:SQSTM1
uniprot id: G3RWJ9
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9595:PEAR1
gene id: 9595:PEAR1
uniprot id: G3RDA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CMAS
gene id: 9595:CMAS
uniprot id: G3RGF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9595:DNAJC27
gene id: 9595:DNAJC27
uniprot id: G3QN94
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9595:LEPROT
gene id: 9595:LEPROT
uniprot id: A0A2I2Z0W5
uniprot id: A0A2I2Z5S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9595:ZC3HC1
gene id: 9595:ZC3HC1
uniprot id: A0A2I2Z792
uniprot id: G3RHK2
names: Subcellular Location Annotation
messages: Nucleus

9595:BRMS1L
gene id: 9595:BRMS1L
uniprot id: G3QU57
names: Subcellular Location Annotation
messages: Nucleus

9595:ECH1
gene id: 9595:ECH1
uniprot id: G3QLW6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:ADCY9
gene id: 9595:ADCY9
uniprot id: G3QEG6
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9595:TRIQK
gene id: 9595:TRIQK
uniprot id: A0A2I2Y3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:GCLC
gene id: 9595:GCLC
uniprot id: G3QV17
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9595:CCNO
gene id: 9595:CCNO
uniprot id: G3R198
names: Similarity
messages: Belongs to the cyclin family.

9595:NXT1
gene id: 9595:NXT1
uniprot id: G3R9X8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9595:FNTB
gene id: 9595:FNTB
uniprot id: G3R1C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9595:SRRD
gene id: 9595:SRRD
uniprot id: G3QQM6
names: Similarity
messages: Belongs to the SRR1 family.

9595:CCT8
gene id: 9595:CCT8
uniprot id: G3QU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9595:LOC101148015
gene id: 9595:LOC101148015
uniprot id: G3RQ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CXCL9
gene id: 9595:CXCL9
uniprot id: G3QPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:MED22
gene id: 9595:MED22
uniprot id: G3RET4
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9595:DHX8
gene id: 9595:DHX8
uniprot id: G3SFV7
names: Subcellular Location Annotation
messages: Nucleus

9595:ITGA2
gene id: 9595:ITGA2
uniprot id: G3QG21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:GLYATL1
gene id: 9595:GLYATL1
uniprot id: G3RY77
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9595:NR1H3
gene id: 9595:NR1H3
uniprot id: A0A2I2ZHW6
uniprot id: G3QZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:LTV1
gene id: 9595:LTV1
uniprot id: G3SJE5
names: Similarity
messages: Belongs to the LTV1 family.

9595:IL12RB1
gene id: 9595:IL12RB1
uniprot id: G3QKI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:SERPINB8
gene id: 9595:SERPINB8
uniprot id: A0A2I2Y8D1
uniprot id: G3R7L5
uniprot id: G3R8G6
names: Similarity
messages: Belongs to the serpin family.

9595:GAB3
gene id: 9595:GAB3
uniprot id: G3QFF6
uniprot id: G3RM77
names: Similarity
messages: Belongs to the GAB family.

9595:VPS36
gene id: 9595:VPS36
uniprot id: G3QYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9595:S100A9
gene id: 9595:S100A9
uniprot id: G3QEY7
names: Similarity
messages: Belongs to the S-100 family.

9595:RMI1
gene id: 9595:RMI1
uniprot id: G3RE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9595:CKAP2L
gene id: 9595:CKAP2L
uniprot id: G3SK27
names: Similarity
messages: Belongs to the CKAP2 family.

9595:TFDP2
gene id: 9595:TFDP2
uniprot id: A0A2I2Z1J2
uniprot id: A0A2I2Z1L1
uniprot id: A0A2I2Z4W9
uniprot id: G3QXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:CXHXorf56
gene id: 9595:CXHXorf56
uniprot id: G3RBX9
names: Similarity
messages: Belongs to the STEEP1 family.

9595:LOC101152035
gene id: 9595:LOC101152035
uniprot id: G3SFC0
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9595:ALKBH3
gene id: 9595:ALKBH3
uniprot id: G3QHR7
names: Similarity
messages: Belongs to the alkB family.

9595:RXFP2
gene id: 9595:RXFP2
uniprot id: G3QJL3
uniprot id: G3S9D5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ARSK
gene id: 9595:ARSK
uniprot id: G3QSM2
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:PRXL2A
gene id: 9595:PRXL2A
uniprot id: G3RBQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9595:LOC101135314
gene id: 9595:LOC101135314
uniprot id: G3SA70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:EIF3I
gene id: 9595:EIF3I
uniprot id: G3QGU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9595:USP45
gene id: 9595:USP45
uniprot id: G3RMD4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:ROMO1
gene id: 9595:ROMO1
uniprot id: A0A2I2ZHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9595:TCEA3
gene id: 9595:TCEA3
uniprot id: G3RYH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9595:NAXD
gene id: 9595:NAXD
uniprot id: G3R6K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

9595:SNRPA1
gene id: 9595:SNRPA1
uniprot id: G3RZB2
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9595:PLXNB3
gene id: 9595:PLXNB3
uniprot id: A0A2I2YXF1
uniprot id: G3RNG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ASB7
gene id: 9595:ASB7
uniprot id: A0A2I2ZMY0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:LOC101147034
gene id: 9595:LOC101147034
uniprot id: G3QTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:SLC9B2
gene id: 9595:SLC9B2
uniprot id: G3S0T5
names: Subcellular Location Annotation
messages: Membrane

9595:XIRP2
gene id: 9595:XIRP2
uniprot id: A0A2I2Y538
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9595:MUSK
gene id: 9595:MUSK
uniprot id: A0A2I2YYW2
uniprot id: G3RHZ7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:KIF20B
gene id: 9595:KIF20B
uniprot id: G3QED3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:ESF1
gene id: 9595:ESF1
uniprot id: G3QUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9595:SFN
gene id: 9595:SFN
uniprot id: G3R777
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:CABS1
gene id: 9595:CABS1
uniprot id: G3QQX9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9595:GBP4
gene id: 9595:GBP4
uniprot id: G3RC82
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:MYH10
gene id: 9595:MYH10
uniprot id: A0A2I2ZLM5
uniprot id: G3SAH0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:MMP13
gene id: 9595:MMP13
uniprot id: A0A2I2ZXV6
uniprot id: G3QLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9595:GOLGA5
gene id: 9595:GOLGA5
uniprot id: G3SJM4
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9595:A4GNT
gene id: 9595:A4GNT
uniprot id: G3QPH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9595:AQP3
gene id: 9595:AQP3
uniprot id: G3QN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9595:NDUFC2
gene id: 9595:NDUFC2
uniprot id: Q0MQF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Mitochondrion inner membrane

9595:ZC2HC1C
gene id: 9595:ZC2HC1C
uniprot id: G3SBR6
names: Similarity
messages: Belongs to the ZC2HC1 family.

9595:SERPINE1
gene id: 9595:SERPINE1
uniprot id: G3QW76
names: Similarity
messages: Belongs to the serpin family.

9595:NXPH2
gene id: 9595:NXPH2
uniprot id: G3RWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9595:BTD
gene id: 9595:BTD
uniprot id: G3RR06
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:CSN3
gene id: 9595:CSN3
uniprot id: G3QUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9595:TSPAN31
gene id: 9595:TSPAN31
uniprot id: G3SDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:EPHA6
gene id: 9595:EPHA6
uniprot id: G3SKT8
names: Subcellular Location Annotation
messages: Membrane

9595:CCDC93
gene id: 9595:CCDC93
uniprot id: G3SJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9595:OSMR
gene id: 9595:OSMR
uniprot id: G3RF68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:ALG8
gene id: 9595:ALG8
uniprot id: G3R7I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TADA3
gene id: 9595:TADA3
uniprot id: G3REE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9595:SLC35F1
gene id: 9595:SLC35F1
uniprot id: G3SGU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9595:TMEM244
gene id: 9595:TMEM244
uniprot id: G3RXN8
names: Subcellular Location Annotation
messages: Membrane

9595:PIGC
gene id: 9595:PIGC
uniprot id: G3RVE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9595:TOM1
gene id: 9595:TOM1
uniprot id: A0A2I2ZKN0
names: Similarity
messages: Belongs to the TOM1 family.

9595:LOC101148684
gene id: 9595:LOC101148684
uniprot id: G3SKC3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9595:POGLUT3
gene id: 9595:POGLUT3
uniprot id: G3R4Z5
names: Similarity
messages: Belongs to the KDELC family.

9595:SEC61A2
gene id: 9595:SEC61A2
uniprot id: G3R0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:IBSP
gene id: 9595:IBSP
uniprot id: G3QVT7
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9595:CCN4
gene id: 9595:CCN4
uniprot id: A0A2I2YC54
uniprot id: A0A2I2Z7K7
uniprot id: G3RGS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:PRR15
gene id: 9595:PRR15
uniprot id: A0A2I2YZD5
names: Similarity
messages: Belongs to the PRR15 family.

9595:TXNL4A
gene id: 9595:TXNL4A
uniprot id: A0A2I2YVL8
uniprot id: G3QRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9595:TAMM41
gene id: 9595:TAMM41
uniprot id: A0A2I2YPY6
uniprot id: A0A2I2YYF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9595:BCL7C
gene id: 9595:BCL7C
uniprot id: G3QSJ5
names: Similarity
messages: Belongs to the BCL7 family.

9595:BAG6
gene id: 9595:BAG6
uniprot id: A0A2I2ZNR6
uniprot id: G3QS02
uniprot id: G3SDX2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9595:PITPNM2
gene id: 9595:PITPNM2
uniprot id: G3QDZ6
uniprot id: G3S0W3
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9595:PTGDR
gene id: 9595:PTGDR
uniprot id: G3R4K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:GPRC5D
gene id: 9595:GPRC5D
uniprot id: G3QF01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:RAB33B
gene id: 9595:RAB33B
uniprot id: A0A2I2Z7M4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9595:LOC101134814
gene id: 9595:LOC101134814
uniprot id: G3S4D2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:SUGT1
gene id: 9595:SUGT1
uniprot id: G3QV95
uniprot id: G3RNH5
names: Similarity
messages: Belongs to the SGT1 family.

9595:LOC101125840
gene id: 9595:LOC101125840
uniprot id: G3SGM5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9595:THRA
gene id: 9595:THRA
uniprot id: G3R2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:MAFB
gene id: 9595:MAFB
uniprot id: G3QFX4
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

9595:RPS6KB2
gene id: 9595:RPS6KB2
uniprot id: G3R3D8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:GABRG3
gene id: 9595:GABRG3
uniprot id: A0A2I2ZXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:RNMT
gene id: 9595:RNMT
uniprot id: G3QRZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9595:MTMR9
gene id: 9595:MTMR9
uniprot id: G3RJI2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9595:GPLD1
gene id: 9595:GPLD1
uniprot id: A0A2I2YDH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9595:SNX31
gene id: 9595:SNX31
uniprot id: G3SJX2
names: Similarity
messages: Belongs to the sorting nexin family.

9595:IDO1
gene id: 9595:IDO1
uniprot id: G3SJC1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9595:SLC35D1
gene id: 9595:SLC35D1
uniprot id: G3R0Z0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC6A17
gene id: 9595:SLC6A17
uniprot id: G3RBF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:HMGB3
gene id: 9595:HMGB3
uniprot id: G3S2A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9595:VHL
gene id: 9595:VHL
uniprot id: A0A2I2Y385
uniprot id: G3R4I8
names: Similarity
messages: Belongs to the VHL family.

9595:KCNK10
gene id: 9595:KCNK10
uniprot id: A0A2I2ZIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:MINAR1
gene id: 9595:MINAR1
uniprot id: G3R9M4
names: Similarity
messages: Belongs to the MINAR family.

9595:UTP11
gene id: 9595:UTP11
uniprot id: A0A2I2YQU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9595:CLK2
gene id: 9595:CLK2
uniprot id: G3R1Y8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ATP6V0B
gene id: 9595:ATP6V0B
uniprot id: A0A2I2ZUX7
uniprot id: G3QM50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9595:BAAT
gene id: 9595:BAAT
uniprot id: G3RHU9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9595:SDHAF4
gene id: 9595:SDHAF4
uniprot id: A0A2I2ZY75
names: Similarity
messages: Belongs to the SDHAF4 family.

9595:HBP1
gene id: 9595:HBP1
uniprot id: G3QXR1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9595:MARS2
gene id: 9595:MARS2
uniprot id: G3SKQ2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:LOC101135678
gene id: 9595:LOC101135678
uniprot id: A0A2I2ZHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101151536
gene id: 9595:LOC101151536
uniprot id: G3R3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9595:LLPH
gene id: 9595:LLPH
uniprot id: G3SJL3
names: Similarity
messages: Belongs to the learning-associated protein family.

9595:TSPAN4
gene id: 9595:TSPAN4
uniprot id: G3R5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:CHRM1
gene id: 9595:CHRM1
uniprot id: G3RJP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9595:HRH1
gene id: 9595:HRH1
uniprot id: Q9N2B1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
messages: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation.

9595:ZNF326
gene id: 9595:ZNF326
uniprot id: G3SAC9
names: Similarity
messages: Belongs to the AKAP95 family.

9595:TAGLN
gene id: 9595:TAGLN
uniprot id: A0A2I2YBG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9595:CFL2
gene id: 9595:CFL2
uniprot id: G3QVF0
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9595:ACSL4
gene id: 9595:ACSL4
uniprot id: A0A2I2Y442
uniprot id: G3QZV5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:VARS1
gene id: 9595:VARS1
uniprot id: G3R6X1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:CRABP1
gene id: 9595:CRABP1
uniprot id: G3R4H6
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

9595:TRMT61A
gene id: 9595:TRMT61A
uniprot id: G3RSR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9595:ACO2
gene id: 9595:ACO2
uniprot id: G3QFL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9595:ASF1A
gene id: 9595:ASF1A
uniprot id: G3R3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9595:SYNGR4
gene id: 9595:SYNGR4
uniprot id: G3SAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9595:ADAMTS16
gene id: 9595:ADAMTS16
uniprot id: G3RFX7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:LOC101144264
gene id: 9595:LOC101144264
uniprot id: G3R156
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:GRN
gene id: 9595:GRN
uniprot id: G3RIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9595:RAB27A
gene id: 9595:RAB27A
uniprot id: G3RF09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9595:LOXL2
gene id: 9595:LOXL2
uniprot id: G3RD94
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:PSMD6
gene id: 9595:PSMD6
uniprot id: A0A2I2YHP3
uniprot id: G3QP60
uniprot id: G3RPJ8
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

9595:ELL3
gene id: 9595:ELL3
uniprot id: G3RBP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9595:HOXC12
gene id: 9595:HOXC12
uniprot id: G3RNH1
names: Subcellular Location Annotation
messages: Nucleus

9595:DDX49
gene id: 9595:DDX49
uniprot id: A0A2I2ZVB8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:LOC101127756
gene id: 9595:LOC101127756
uniprot id: G3SCT4
names: Similarity
messages: Belongs to the copine family.

9595:GTPBP3
gene id: 9595:GTPBP3
uniprot id: G3RHS2
uniprot id: G3S773
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9595:LOC101130686
gene id: 9595:LOC101130686
uniprot id: G3RWS7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9595:TAFA1
gene id: 9595:TAFA1
uniprot id: G3R7U2
names: Similarity
messages: Belongs to the TAFA family.

9595:KIF14
gene id: 9595:KIF14
uniprot id: G3RD87
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:CENPM
gene id: 9595:CENPM
uniprot id: A0A2I2YLT8
uniprot id: A0A2I2ZDJ6
names: Subcellular Location Annotation
messages: Nucleus

9595:PNOC
gene id: 9595:PNOC
uniprot id: G3RI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9595:DUS4L
gene id: 9595:DUS4L
uniprot id: G3QML1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9595:HOXD12
gene id: 9595:HOXD12
uniprot id: G3QG72
names: Subcellular Location Annotation
messages: Nucleus

9595:ZSCAN16
gene id: 9595:ZSCAN16
uniprot id: G3RXS8
names: Subcellular Location Annotation
messages: Nucleus

9595:P4HA2
gene id: 9595:P4HA2
uniprot id: G3SJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9595:SMIM22
gene id: 9595:SMIM22
uniprot id: A0A2I2YEH1
names: Subcellular Location Annotation
messages: Membrane

9595:HEPH
gene id: 9595:HEPH
uniprot id: G3R124
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:SNRPN
gene id: 9595:SNRPN
uniprot id: G3SJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9595:GABRB1
gene id: 9595:GABRB1
uniprot id: G3SKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:IL9
gene id: 9595:IL9
uniprot id: G3RE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9595:F3
gene id: 9595:F3
uniprot id: A0A2I2YXP6
uniprot id: G3RFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9595:ASB11
gene id: 9595:ASB11
uniprot id: A0A2I2Z203
uniprot id: G3QWH5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:PDGFRB
gene id: 9595:PDGFRB
uniprot id: G3QWE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9595:MCTS1
gene id: 9595:MCTS1
uniprot id: A0A2I2ZX76
uniprot id: G3R1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9595:VAMP4
gene id: 9595:VAMP4
uniprot id: G3SIP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:GNPTAB
gene id: 9595:GNPTAB
uniprot id: G3R2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9595:ADRA2A
gene id: 9595:ADRA2A
uniprot id: G3S6R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SERPINA11
gene id: 9595:SERPINA11
uniprot id: G3QN70
names: Similarity
messages: Belongs to the serpin family.

9595:MTG2
gene id: 9595:MTG2
uniprot id: G3QS99
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9595:KRT78
gene id: 9595:KRT78
uniprot id: A0A2I2YAM9
uniprot id: G3QMQ7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:CDK2AP1
gene id: 9595:CDK2AP1
uniprot id: A0A2I2Z8T4
uniprot id: G3R2A0
names: Similarity
messages: Belongs to the CDK2AP family.

9595:PLCB2
gene id: 9595:PLCB2
uniprot id: A0A2I2Z4L6
uniprot id: G3QEQ0
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9595:FGF18
gene id: 9595:FGF18
uniprot id: G3QWB5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:FMO5
gene id: 9595:FMO5
uniprot id: G3S9Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9595:OLFML2B
gene id: 9595:OLFML2B
uniprot id: G3R0H9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TMLHE
gene id: 9595:TMLHE
uniprot id: G3S446
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9595:CALHM6
gene id: 9595:CALHM6
uniprot id: G3QGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:SRSF1
gene id: 9595:SRSF1
uniprot id: G3QP16
names: Similarity
messages: Belongs to the splicing factor SR family.

9595:POU2F2
gene id: 9595:POU2F2
uniprot id: G3R671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9595:PCSK2
gene id: 9595:PCSK2
uniprot id: G3QWE4
names: Similarity
messages: Belongs to the peptidase S8 family.

9595:RP2
gene id: 9595:RP2
uniprot id: G3QUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9595:FAM124A
gene id: 9595:FAM124A
uniprot id: G3SK63
names: Similarity
messages: Belongs to the FAM124 family.

9595:GSTO1
gene id: 9595:GSTO1
uniprot id: A0A2I2YFL5
uniprot id: G3QQT9
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9595:SLC11A1
gene id: 9595:SLC11A1
uniprot id: G3RC10
names: Similarity
messages: Belongs to the NRAMP family.

9595:FAM98A
gene id: 9595:FAM98A
uniprot id: G3SJ47
names: Similarity
messages: Belongs to the FAM98 family.

9595:MNAT1
gene id: 9595:MNAT1
uniprot id: G3R164
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9595:MTHFS
gene id: 9595:MTHFS
uniprot id: A0A2I2ZGX5
uniprot id: G3R914
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9595:STMN1
gene id: 9595:STMN1
uniprot id: G3S1A3
names: Similarity
messages: Belongs to the stathmin family.

9595:TSPAN15
gene id: 9595:TSPAN15
uniprot id: G3QXQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:LIFR
gene id: 9595:LIFR
uniprot id: G3RGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:CNKSR3
gene id: 9595:CNKSR3
uniprot id: G3QFX6
names: Similarity
messages: Belongs to the CNKSR family.

9595:MAPKAP1
gene id: 9595:MAPKAP1
uniprot id: A0A2I2Y7P7
uniprot id: A0A2I2YV76
uniprot id: G3QT17
uniprot id: G3RMW5
names: Similarity
messages: Belongs to the SIN1 family.

9595:LOC101149661
gene id: 9595:LOC101149661
uniprot id: G3QZM1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9595:CHRND
gene id: 9595:CHRND
uniprot id: A0A2I2YBJ0
uniprot id: G3QI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:SDAD1
gene id: 9595:SDAD1
uniprot id: G3QUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9595:PKN1
gene id: 9595:PKN1
uniprot id: A0A2I2Y7S7
uniprot id: G3RIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9595:ANKRD34A
gene id: 9595:ANKRD34A
uniprot id: A0A2I2YNF1
names: Similarity
messages: Belongs to the ANKRD34 family.

9595:DNAJA1
gene id: 9595:DNAJA1
uniprot id: G3QVU3
names: Subcellular Location Annotation
messages: Membrane

9595:PRDX5
gene id: 9595:PRDX5
uniprot id: G3QG68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9595:SCGB2A2
gene id: 9595:SCGB2A2
uniprot id: G3QU17
names: Subcellular Location Annotation
messages: Secreted

9595:DKK2
gene id: 9595:DKK2
uniprot id: A0A2I2ZPL5
names: Similarity
messages: Belongs to the dickkopf family.

9595:CTPS1
gene id: 9595:CTPS1
uniprot id: G3RLW2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9595:PARPBP
gene id: 9595:PARPBP
uniprot id: A0A2I2YQ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9595:SLC5A11
gene id: 9595:SLC5A11
uniprot id: A0A2I2YWT2
uniprot id: G3QH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9595:SNRPD2
gene id: 9595:SNRPD2
uniprot id: G3QIU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9595:PLA2G2F
gene id: 9595:PLA2G2F
uniprot id: G3RD85
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:TMEM170B
gene id: 9595:TMEM170B
uniprot id: G3QUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9595:MED10
gene id: 9595:MED10
uniprot id: G3QKQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:LOC109024475
gene id: 9595:LOC109024475
uniprot id: G3RG10
names: Similarity
messages: Belongs to the KRTAP type 6 family.

9595:KIF1C
gene id: 9595:KIF1C
uniprot id: G3R1E6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:STARD3NL
gene id: 9595:STARD3NL
uniprot id: A0A2I2ZEJ6
uniprot id: G3RCB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:GNG12
gene id: 9595:GNG12
uniprot id: A0A2I2YIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:EDN1
gene id: 9595:EDN1
uniprot id: G3RBV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9595:SLC7A6OS
gene id: 9595:SLC7A6OS
uniprot id: G3QGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9595:PIR
gene id: 9595:PIR
uniprot id: G3QJY8
names: Similarity
messages: Belongs to the pirin family.

9595:C3AR1
gene id: 9595:C3AR1
uniprot id: G3RG02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9595:RPA3
gene id: 9595:RPA3
uniprot id: G3SDA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9595:NDUFB6
gene id: 9595:NDUFB6
uniprot id: Q0MQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:LOC101151126
gene id: 9595:LOC101151126
uniprot id: G3QJ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SRXN1
gene id: 9595:SRXN1
uniprot id: G3RKU5
names: Similarity
messages: Belongs to the sulfiredoxin family.

9595:ELAVL4
gene id: 9595:ELAVL4
uniprot id: A0A2I2YP86
uniprot id: A0A2I2Z663
uniprot id: A0A2I2ZAQ5
uniprot id: G3QED2
uniprot id: G3SHV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9595:MAP2K5
gene id: 9595:MAP2K5
uniprot id: A0A2I2ZBX6
uniprot id: A0A2I2ZQT1
uniprot id: G3QPY6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ENOPH1
gene id: 9595:ENOPH1
uniprot id: G3QMC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9595:ADIPOR1
gene id: 9595:ADIPOR1
uniprot id: G3QQZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:RPL7A
gene id: 9595:RPL7A
uniprot id: G3REU2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9595:CSF2
gene id: 9595:CSF2
uniprot id: G3QFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9595:FBXO25
gene id: 9595:FBXO25
uniprot id: G3S6L8
names: Subcellular Location Annotation
messages: Nucleus

9595:L3MBTL4
gene id: 9595:L3MBTL4
uniprot id: A0A2I2ZK46
uniprot id: G3RSN8
names: Subcellular Location Annotation
messages: Nucleus

9595:LTBP2
gene id: 9595:LTBP2
uniprot id: G3SCK9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:PIGM
gene id: 9595:PIGM
uniprot id: G3S4N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9595:KAT5
gene id: 9595:KAT5
uniprot id: A0A2I2ZJT3
uniprot id: G3S5C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9595:LIX1
gene id: 9595:LIX1
uniprot id: G3R9W1
names: Similarity
messages: Belongs to the LIX1 family.

9595:LIPA
gene id: 9595:LIPA
uniprot id: G3QN03
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:KIF23
gene id: 9595:KIF23
uniprot id: A0A2I2YC58
uniprot id: G3QN02
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:PRUNE1
gene id: 9595:PRUNE1
uniprot id: A0A2I2YG44
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9595:ZSCAN31
gene id: 9595:ZSCAN31
uniprot id: G3QRZ8
names: Subcellular Location Annotation
messages: Nucleus

9595:DACT1
gene id: 9595:DACT1
uniprot id: G3RRC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9595:FAM174A
gene id: 9595:FAM174A
uniprot id: A0A2I2Y9N3
uniprot id: A0A2I2ZSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9595:BEX2
gene id: 9595:BEX2
uniprot id: G3QS69
names: Similarity
messages: Belongs to the BEX family.

9595:AKT2
gene id: 9595:AKT2
uniprot id: A0A2I2YDQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9595:GABARAP
gene id: 9595:GABARAP
uniprot id: G3RD36
names: Similarity
messages: Belongs to the ATG8 family.

9595:AQP6
gene id: 9595:AQP6
uniprot id: G3QSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:GABRA4
gene id: 9595:GABRA4
uniprot id: G3RPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:MTMR3
gene id: 9595:MTMR3
uniprot id: A0A2I2Z1T1
uniprot id: G3QTV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9595:LOC101154047
gene id: 9595:LOC101154047
uniprot id: G3RIC3
uniprot id: G3RIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Lysosome
messages: Membrane
messages: cytoskeleton
messages: phagosome

9595:MUS81
gene id: 9595:MUS81
uniprot id: G3R5H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9595:SQLE
gene id: 9595:SQLE
uniprot id: G3QWK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9595:SEPSECS
gene id: 9595:SEPSECS
uniprot id: G3RRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9595:TAF13
gene id: 9595:TAF13
uniprot id: G3R267
names: Subcellular Location Annotation
messages: Nucleus

9595:MAN1C1
gene id: 9595:MAN1C1
uniprot id: G3R750
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:CCNYL1
gene id: 9595:CCNYL1
uniprot id: A0A2I2Y7M7
uniprot id: A0A2I2Z0Z9
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9595:NUDT1
gene id: 9595:NUDT1
uniprot id: G3RNY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9595:CCR7
gene id: 9595:CCR7
uniprot id: G3RJP4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:MMD2
gene id: 9595:MMD2
uniprot id: G3SEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:ALDH18A1
gene id: 9595:ALDH18A1
uniprot id: G3R9U3
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9595:RPL11
gene id: 9595:RPL11
uniprot id: G3RWD2
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9595:BEST2
gene id: 9595:BEST2
uniprot id: G3QS17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9595:KRT8
gene id: 9595:KRT8
uniprot id: G3SEY3
names: Similarity
messages: Belongs to the intermediate filament family.

9595:DOK2
gene id: 9595:DOK2
uniprot id: G3QD93
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9595:CXXC5
gene id: 9595:CXXC5
uniprot id: G3RE56
names: Subcellular Location Annotation
messages: Cytoplasm

9595:MAPK8
gene id: 9595:MAPK8
uniprot id: A0A2I2ZC90
uniprot id: A0A2I2ZPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9595:LOC109029095
gene id: 9595:LOC109029095
uniprot id: A0A2I2YEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:IL1A
gene id: 9595:IL1A
uniprot id: G3QLV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9595:LPIN2
gene id: 9595:LPIN2
uniprot id: G3QDK3
names: Similarity
messages: Belongs to the lipin family.

9595:MRPS25
gene id: 9595:MRPS25
uniprot id: G3R5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9595:HOXB6
gene id: 9595:HOXB6
uniprot id: G3QJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:SCRN3
gene id: 9595:SCRN3
uniprot id: G3SKU3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9595:CHST4
gene id: 9595:CHST4
uniprot id: G3RIA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:DHPS
gene id: 9595:DHPS
uniprot id: G3RC40
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9595:PARP16
gene id: 9595:PARP16
uniprot id: G3SBT9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:ARG2
gene id: 9595:ARG2
uniprot id: G3QS73
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9595:STXBP5
gene id: 9595:STXBP5
uniprot id: G3R7D6
uniprot id: G3RL45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:CXCL5
gene id: 9595:CXCL5
uniprot id: G3SIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:NDUFB9
gene id: 9595:NDUFB9
uniprot id: Q0MQE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:EXOC3L4
gene id: 9595:EXOC3L4
uniprot id: G3RKM6
names: Similarity
messages: Belongs to the SEC6 family.

9595:IFI35
gene id: 9595:IFI35
uniprot id: G3R0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9595:CLDN15
gene id: 9595:CLDN15
uniprot id: G3SCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:LOC101144978
gene id: 9595:LOC101144978
uniprot id: G3RE85
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:TJP3
gene id: 9595:TJP3
uniprot id: G3S0I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:SPRTN
gene id: 9595:SPRTN
uniprot id: G3QKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9595:MRPS18A
gene id: 9595:MRPS18A
uniprot id: G3SCE1
names: Subcellular Location Annotation
messages: Mitochondrion

9595:ADRA1B
gene id: 9595:ADRA1B
uniprot id: G3QHV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9595:ZDHHC15
gene id: 9595:ZDHHC15
uniprot id: A0A2I2YGP2
uniprot id: G3S7L3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:ADGRF1
gene id: 9595:ADGRF1
uniprot id: G3SEQ2
names: Subcellular Location Annotation
messages: Membrane

9595:PURB
gene id: 9595:PURB
uniprot id: G3SF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9595:MYMK
gene id: 9595:MYMK
uniprot id: G3RFK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9595:NUP88
gene id: 9595:NUP88
uniprot id: A0A2I2YF80
names: Subcellular Location Annotation
messages: nuclear pore complex

9595:LAMC2
gene id: 9595:LAMC2
uniprot id: G3RF36
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9595:TIGD4
gene id: 9595:TIGD4
uniprot id: G3R842
names: Subcellular Location Annotation
messages: Nucleus

9595:NDRG4
gene id: 9595:NDRG4
uniprot id: A0A2I2Y8X7
uniprot id: A0A2I2ZFZ6
uniprot id: G3R275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9595:KDSR
gene id: 9595:KDSR
uniprot id: G3RBX4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:PEA15
gene id: 9595:PEA15
uniprot id: G3RB66
names: Subcellular Location Annotation
messages: Cytoplasm

9595:ATR
gene id: 9595:ATR
uniprot id: A0A2I2YTG6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9595:MRPL47
gene id: 9595:MRPL47
uniprot id: G3RSK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9595:CTSV
gene id: 9595:CTSV
uniprot id: G3S2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:LPIN1
gene id: 9595:LPIN1
uniprot id: G3QSY1
names: Similarity
messages: Belongs to the lipin family.

9595:LRRC8B
gene id: 9595:LRRC8B
uniprot id: G3QTC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:TXNIP
gene id: 9595:TXNIP
uniprot id: G3R848
names: Similarity
messages: Belongs to the arrestin family.

9595:CCNG1
gene id: 9595:CCNG1
uniprot id: G3QPW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9595:MADD
gene id: 9595:MADD
uniprot id: A0A2I2YJV3
uniprot id: A0A2I2YVS3
uniprot id: A0A2I2Z9X1
uniprot id: G3QZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:ANP32E
gene id: 9595:ANP32E
uniprot id: A0A2I2Y1Y2
names: Similarity
messages: Belongs to the ANP32 family.

9595:CD164L2
gene id: 9595:CD164L2
uniprot id: G3RR38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:PADI3
gene id: 9595:PADI3
uniprot id: G3RGV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:GCGR
gene id: 9595:GCGR
uniprot id: G3RNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9595:AMIGO3
gene id: 9595:AMIGO3
uniprot id: G3R4Y9
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9595:SLC26A2
gene id: 9595:SLC26A2
uniprot id: G3QE35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9595:DMRT1
gene id: 9595:DMRT1
uniprot id: G3S0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:HOXA1
gene id: 9595:HOXA1
uniprot id: G3QIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9595:LYPD6
gene id: 9595:LYPD6
uniprot id: G3QWS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:TAP2
gene id: 9595:TAP2
uniprot id: G3RWW2
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9595:GABPA
gene id: 9595:GABPA
uniprot id: G3RDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:NSUN7
gene id: 9595:NSUN7
uniprot id: A0A2I2YXN1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LUC7L3
gene id: 9595:LUC7L3
uniprot id: A0A2I2YXZ3
uniprot id: A0A2I2ZKX8
uniprot id: G3S0S9
names: Similarity
messages: Belongs to the Luc7 family.

9595:IL1RAPL2
gene id: 9595:IL1RAPL2
uniprot id: G3QJX3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:LOC101144032
gene id: 9595:LOC101144032
uniprot id: G3R5A0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9595:LOC109025096
gene id: 9595:LOC109025096
uniprot id: A0A2I2ZG17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:ARL8A
gene id: 9595:ARL8A
uniprot id: G3S521
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9595:MS4A1
gene id: 9595:MS4A1
uniprot id: A0A2I2Y644
names: Similarity
messages: Belongs to the MS4A family.

9595:TMEM255A
gene id: 9595:TMEM255A
uniprot id: A0A2I2ZM24
uniprot id: G3R472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9595:LOC101141762
gene id: 9595:LOC101141762
uniprot id: G3QND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9595:ILVBL
gene id: 9595:ILVBL
uniprot id: G3R4U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9595:TRAF5
gene id: 9595:TRAF5
uniprot id: G3RAK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9595:LOC101138067
gene id: 9595:LOC101138067
uniprot id: G3RFI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:SERPINF2
gene id: 9595:SERPINF2
uniprot id: G3S7C3
names: Similarity
messages: Belongs to the serpin family.

9595:AHCYL1
gene id: 9595:AHCYL1
uniprot id: A0A2I2Z1F3
uniprot id: G3R806
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9595:FTH1
gene id: 9595:FTH1
uniprot id: G3RMF9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9595:TGIF2
gene id: 9595:TGIF2
uniprot id: G3R7Z0
names: Subcellular Location Annotation
messages: Nucleus

9595:GSTM4
gene id: 9595:GSTM4
uniprot id: A0A2I2Z385
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9595:TP53RK
gene id: 9595:TP53RK
uniprot id: G3QI33
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9595:MMP2
gene id: 9595:MMP2
uniprot id: A0A2I2ZH84
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
messages: extracellular matrix

9595:GYS2
gene id: 9595:GYS2
uniprot id: G3QU91
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9595:TSPO2
gene id: 9595:TSPO2
uniprot id: G3R8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9595:CD5
gene id: 9595:CD5
uniprot id: G3QUT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ALKBH6
gene id: 9595:ALKBH6
uniprot id: A0A2I2ZG06
uniprot id: A0A2I2ZR67
names: Similarity
messages: Belongs to the alkB family.

9595:CCR9
gene id: 9595:CCR9
uniprot id: G3QQ18
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:KCNH8
gene id: 9595:KCNH8
uniprot id: G3RMV3
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9595:TEKT5
gene id: 9595:TEKT5
uniprot id: G3QVU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9595:PRDM13
gene id: 9595:PRDM13
uniprot id: G3QVL8
names: Subcellular Location Annotation
messages: Nucleus

9595:SEMA5B
gene id: 9595:SEMA5B
uniprot id: G3QXA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SCAND1
gene id: 9595:SCAND1
uniprot id: A0A2K5TIX9
names: Subcellular Location Annotation
messages: Nucleus

9595:EXOC1
gene id: 9595:EXOC1
uniprot id: A0A2I2YXC6
uniprot id: G3RNH4
names: Similarity
messages: Belongs to the SEC3 family.

9595:DMTN
gene id: 9595:DMTN
uniprot id: A0A2I2YCG0
uniprot id: A0A2I2YYD6
uniprot id: G3SJV3
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SLC1A1
gene id: 9595:SLC1A1
uniprot id: G3QDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:HMGN1
gene id: 9595:HMGN1
uniprot id: G3RCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:UBQLN1
gene id: 9595:UBQLN1
uniprot id: G3RJG8
uniprot id: G3S4J6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9595:DLX4
gene id: 9595:DLX4
uniprot id: G3RG88
names: Subcellular Location Annotation
messages: Nucleus

9595:ATG7
gene id: 9595:ATG7
uniprot id: A0A2I2ZVZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9595:HPRT1
gene id: 9595:HPRT1
uniprot id: G3SIK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9595:SLC44A5
gene id: 9595:SLC44A5
uniprot id: A0A2I2YXU8
uniprot id: G3QVV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9595:CERS3
gene id: 9595:CERS3
uniprot id: G3S701
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9595:HOPX
gene id: 9595:HOPX
uniprot id: G3RUB5
uniprot id: G3SAU5
names: Subcellular Location Annotation
messages: Nucleus

9595:MAGT1
gene id: 9595:MAGT1
uniprot id: G3R499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:MTFR2
gene id: 9595:MTFR2
uniprot id: G3R0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9595:ZDHHC17
gene id: 9595:ZDHHC17
uniprot id: G3SEE3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:SFXN4
gene id: 9595:SFXN4
uniprot id: A0A2I2ZE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9595:KCNK9
gene id: 9595:KCNK9
uniprot id: A0A2I2ZP69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9595:KARS1
gene id: 9595:KARS1
uniprot id: A0A2I2ZRC2
uniprot id: G3QRY3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9595:GPR65
gene id: 9595:GPR65
uniprot id: G3RXN3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:RICTOR
gene id: 9595:RICTOR
uniprot id: A0A2I2ZHJ0
uniprot id: G3S715
names: Similarity
messages: Belongs to the RICTOR family.

9595:DGCR2
gene id: 9595:DGCR2
uniprot id: G3S915
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CREB3L2
gene id: 9595:CREB3L2
uniprot id: G3QNM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9595:SHCBP1
gene id: 9595:SHCBP1
uniprot id: G3R5S3
names: Subcellular Location Annotation
messages: spindle

9595:ZSCAN25
gene id: 9595:ZSCAN25
uniprot id: G3RLA2
names: Subcellular Location Annotation
messages: Nucleus

9595:RPS7
gene id: 9595:RPS7
uniprot id: G3S299
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9595:PON3
gene id: 9595:PON3
uniprot id: G3RBS0
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9595:DAP3
gene id: 9595:DAP3
uniprot id: G3QXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9595:ARRB1
gene id: 9595:ARRB1
uniprot id: A0A2I2ZB40
uniprot id: G3R2M1
names: Similarity
messages: Belongs to the arrestin family.

9595:VDR
gene id: 9595:VDR
uniprot id: G3RK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:GABRP
gene id: 9595:GABRP
uniprot id: A0A2I2ZG30
uniprot id: G3QMM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:ANK2
gene id: 9595:ANK2
uniprot id: A0A2I2Y5T8
uniprot id: G3S4C5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:WNT2B
gene id: 9595:WNT2B
uniprot id: A0A2I2ZFY1
uniprot id: G3QM25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:AVPR1B
gene id: 9595:AVPR1B
uniprot id: G3RB98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9595:NOB1
gene id: 9595:NOB1
uniprot id: G3SFM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9595:RIN1
gene id: 9595:RIN1
uniprot id: G3R4P0
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9595:GPR161
gene id: 9595:GPR161
uniprot id: A0A2I2Z0H8
uniprot id: A0A2I2ZK05
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:AP1S2
gene id: 9595:AP1S2
uniprot id: A0A2I2YN18
uniprot id: A0A2I2ZIX9
uniprot id: G3RCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9595:ANO10
gene id: 9595:ANO10
uniprot id: G3RE27
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:PGK2
gene id: 9595:PGK2
uniprot id: A0A2I2Z4D3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9595:POLR1E
gene id: 9595:POLR1E
uniprot id: G3QHM1
uniprot id: G3RMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9595:SAP130
gene id: 9595:SAP130
uniprot id: A0A2I2YBL8
uniprot id: G3RJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9595:SLC43A2
gene id: 9595:SLC43A2
uniprot id: G3QWR1
uniprot id: G3RS89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

9595:ETS1
gene id: 9595:ETS1
uniprot id: A0A2I2YR13
uniprot id: G3QK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9595:PPP2R5A
gene id: 9595:PPP2R5A
uniprot id: A0A2I2YD04
uniprot id: G3SAH2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9595:LOC101125335
gene id: 9595:LOC101125335
uniprot id: G3QP21
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:PDGFRL
gene id: 9595:PDGFRL
uniprot id: G3REV5
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

9595:CLPS
gene id: 9595:CLPS
uniprot id: A0A2I2ZHM3
uniprot id: G3QRE9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9595:DHRS7B
gene id: 9595:DHRS7B
uniprot id: G3QZH0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SEC24D
gene id: 9595:SEC24D
uniprot id: G3QJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:GLUD1
gene id: 9595:GLUD1
uniprot id: G3RI93
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9595:SLC4A5
gene id: 9595:SLC4A5
uniprot id: A0A2I2Z1F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9595:TANGO6
gene id: 9595:TANGO6
uniprot id: G3R3G9
names: Similarity
messages: Belongs to the Tango6 family.

9595:GOLM1
gene id: 9595:GOLM1
uniprot id: G3R9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9595:NAB2
gene id: 9595:NAB2
uniprot id: G3QGE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9595:C11H11orf68
gene id: 9595:C11H11orf68
uniprot id: G3QQ36
names: Similarity
messages: Belongs to the UPF0696 family.

9595:FOXP3
gene id: 9595:FOXP3
uniprot id: A0A2I2Z9W8
uniprot id: G3RR60
names: Subcellular Location Annotation
messages: Nucleus

9595:AFP
gene id: 9595:AFP
uniprot id: G3QZW5
names: Subcellular Location Annotation
messages: Secreted

9595:SCGB1A1
gene id: 9595:SCGB1A1
uniprot id: G3QHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9595:TRMT13
gene id: 9595:TRMT13
uniprot id: G3QS72
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9595:TIPARP
gene id: 9595:TIPARP
uniprot id: G3RX27
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:FBXO46
gene id: 9595:FBXO46
uniprot id: G3RWS6
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9595:SLC52A3
gene id: 9595:SLC52A3
uniprot id: G3QQS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9595:NPM1
gene id: 9595:NPM1
uniprot id: A0A2I2YQY6
uniprot id: G3QWA8
names: Similarity
messages: Belongs to the nucleoplasmin family.

9595:LASP1
gene id: 9595:LASP1
uniprot id: A0A2I2YNI2
uniprot id: A0A2I2YUK1
uniprot id: G3QLF9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9595:ACTN2
gene id: 9595:ACTN2
uniprot id: A0A2I2ZV52
uniprot id: G3R8C5
names: Similarity
messages: Belongs to the alpha-actinin family.

9595:SEC61G
gene id: 9595:SEC61G
uniprot id: G3QSU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:IGFL2
gene id: 9595:IGFL2
uniprot id: G3S3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9595:LOC101139165
gene id: 9595:LOC101139165
uniprot id: G3RGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:MRPL24
gene id: 9595:MRPL24
uniprot id: G3RUI4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9595:MRPL53
gene id: 9595:MRPL53
uniprot id: G3QUG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9595:MAT2B
gene id: 9595:MAT2B
uniprot id: A0A2I2ZDS3
uniprot id: G3S8V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9595:UBE2U
gene id: 9595:UBE2U
uniprot id: G3QGK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:SRFBP1
gene id: 9595:SRFBP1
uniprot id: G3QXL0
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9595:OGN
gene id: 9595:OGN
uniprot id: G3QTN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9595:CLCN6
gene id: 9595:CLCN6
uniprot id: G3SCD3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DCLK1
gene id: 9595:DCLK1
uniprot id: A0A2I2Y344
uniprot id: G3QUA9
uniprot id: G3SIT0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9595:ARV1
gene id: 9595:ARV1
uniprot id: G3S847
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9595:FAM162A
gene id: 9595:FAM162A
uniprot id: G3SB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9595:OPN4
gene id: 9595:OPN4
uniprot id: G3RVR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DLL1
gene id: 9595:DLL1
uniprot id: G3QRX5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:STX18
gene id: 9595:STX18
uniprot id: G3R6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9595:EFHC2
gene id: 9595:EFHC2
uniprot id: G3RA83
names: Subcellular Location Annotation
messages: cilium axoneme

9595:AGPAT1
gene id: 9595:AGPAT1
uniprot id: G3RMU5
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9595:MTUS1
gene id: 9595:MTUS1
uniprot id: A0A2I2Y4C7
uniprot id: A0A2I2Y6Z3
uniprot id: A0A2I2Z066
uniprot id: G3REX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9595:NDNF
gene id: 9595:NDNF
uniprot id: G3QZV0
names: Subcellular Location Annotation
messages: Secreted

9595:MRPS10
gene id: 9595:MRPS10
uniprot id: G3RAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9595:C16H16orf58
gene id: 9595:C16H16orf58
uniprot id: G3QP92
names: Similarity
messages: Belongs to the RUS1 family.

9595:CPM
gene id: 9595:CPM
uniprot id: G3QFY3
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:AKR1E2
gene id: 9595:AKR1E2
uniprot id: A0A2I2YH99
uniprot id: G3R651
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:NPPB
gene id: 9595:NPPB
uniprot id: G3RR78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9595:ELOVL6
gene id: 9595:ELOVL6
uniprot id: G3QDA7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9595:GABBR1
gene id: 9595:GABBR1
uniprot id: A0A2I2Z6U7
uniprot id: G3S7N5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GRM6
gene id: 9595:GRM6
uniprot id: G3R8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:BAZ2A
gene id: 9595:BAZ2A
uniprot id: A0A2I2ZED5
names: Similarity
messages: Belongs to the WAL family.

9595:LSM5
gene id: 9595:LSM5
uniprot id: A0A2I2ZH19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9595:MTMR10
gene id: 9595:MTMR10
uniprot id: G3QHT1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9595:SPTLC3
gene id: 9595:SPTLC3
uniprot id: G3RA20
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9595:CHMP2A
gene id: 9595:CHMP2A
uniprot id: G3S820
names: Similarity
messages: Belongs to the SNF7 family.

9595:DPEP3
gene id: 9595:DPEP3
uniprot id: G3RA55
names: Subcellular Location Annotation
messages: Membrane

9595:MED26
gene id: 9595:MED26
uniprot id: G3S035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9595:GANAB
gene id: 9595:GANAB
uniprot id: A0A2I2Y4E6
uniprot id: G3RCQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9595:SYNPR
gene id: 9595:SYNPR
uniprot id: G3QJ88
uniprot id: G3RUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9595:CFL1
gene id: 9595:CFL1
uniprot id: A0A2I2ZWK6
uniprot id: G3RMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9595:PALMD
gene id: 9595:PALMD
uniprot id: G3SE02
names: Similarity
messages: Belongs to the paralemmin family.

9595:ODC1
gene id: 9595:ODC1
uniprot id: G3QY86
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9595:SEC11C
gene id: 9595:SEC11C
uniprot id: G3RP59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:NDUFS4
gene id: 9595:NDUFS4
uniprot id: Q0MQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct.
messages: Mitochondrion inner membrane

9595:MEGF6
gene id: 9595:MEGF6
uniprot id: G3RQW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EDC3
gene id: 9595:EDC3
uniprot id: G3QLW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9595:CAMK1
gene id: 9595:CAMK1
uniprot id: G3RED6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:INHBB
gene id: 9595:INHBB
uniprot id: G3RH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:FGFR1
gene id: 9595:FGFR1
uniprot id: G3RBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9595:NAV3
gene id: 9595:NAV3
uniprot id: G3SIM3
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9595:RAB5IF
gene id: 9595:RAB5IF
uniprot id: G3RXB4
names: Subcellular Location Annotation
messages: Membrane

9595:MTFMT
gene id: 9595:MTFMT
uniprot id: G3QFN0
names: Similarity
messages: Belongs to the Fmt family.

9595:PES1
gene id: 9595:PES1
uniprot id: G3QZN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9595:CCL22
gene id: 9595:CCL22
uniprot id: A0A2I2ZUR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:LOC101137537
gene id: 9595:LOC101137537
uniprot id: G3QKH6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9595:MYB
gene id: 9595:MYB
uniprot id: A0A2I2YCE7
uniprot id: A0A2I2YD38
uniprot id: A0A2I2YDY2
uniprot id: A0A2I2ZIL5
uniprot id: A0A2I2ZMD6
uniprot id: G3QGB0
names: Subcellular Location Annotation
messages: Nucleus

9595:E2F1
gene id: 9595:E2F1
uniprot id: G3QM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:AMOTL2
gene id: 9595:AMOTL2
uniprot id: G3RKW7
names: Similarity
messages: Belongs to the angiomotin family.

9595:SCRN2
gene id: 9595:SCRN2
uniprot id: G3QPG3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9595:ITGB3BP
gene id: 9595:ITGB3BP
uniprot id: A0A2I2Y3V7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9595:GJD2
gene id: 9595:GJD2
uniprot id: G3S404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:DLGAP5
gene id: 9595:DLGAP5
uniprot id: A0A2I2ZGM2
uniprot id: G3QLP8
names: Similarity
messages: Belongs to the SAPAP family.

9595:AAR2
gene id: 9595:AAR2
uniprot id: G3RWS2
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9595:HSPA5
gene id: 9595:HSPA5
uniprot id: G3S6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

9595:CLDN19
gene id: 9595:CLDN19
uniprot id: A0A2I2YS39
uniprot id: G3QSH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:AFF3
gene id: 9595:AFF3
uniprot id: G3SKU4
names: Similarity
messages: Belongs to the AF4 family.

9595:INTU
gene id: 9595:INTU
uniprot id: G3QKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9595:BBOX1
gene id: 9595:BBOX1
uniprot id: G3R1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9595:NEU1
gene id: 9595:NEU1
uniprot id: G3R0S0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9595:RAB3IP
gene id: 9595:RAB3IP
uniprot id: A0A2I2Y1Y9
uniprot id: G3QZA3
uniprot id: G3RR29
names: Similarity
messages: Belongs to the SEC2 family.

9595:IGF2BP1
gene id: 9595:IGF2BP1
uniprot id: A0A2I2Z4W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9595:GADL1
gene id: 9595:GADL1
uniprot id: G3QCW3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:RPAP1
gene id: 9595:RPAP1
uniprot id: G3QVU2
names: Similarity
messages: Belongs to the RPAP1 family.

9595:GNA12
gene id: 9595:GNA12
uniprot id: G3R227
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9595:ENAH
gene id: 9595:ENAH
uniprot id: A0A2I2Y910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9595:GAL
gene id: 9595:GAL
uniprot id: G3QDD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9595:SCIN
gene id: 9595:SCIN
uniprot id: G3RHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9595:MED27
gene id: 9595:MED27
uniprot id: A0A2I2YFN3
uniprot id: A0A2I2ZIL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:RTN4IP1
gene id: 9595:RTN4IP1
uniprot id: G3QYX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9595:TOR1B
gene id: 9595:TOR1B
uniprot id: G3RC05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9595:THRB
gene id: 9595:THRB
uniprot id: G3QWF5
uniprot id: G3S6W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:MTNR1A
gene id: 9595:MTNR1A
uniprot id: G3R7Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9595:NCL
gene id: 9595:NCL
uniprot id: G3QNU5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9595:ADAT2
gene id: 9595:ADAT2
uniprot id: G3RJA0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9595:ESRRA
gene id: 9595:ESRRA
uniprot id: G3QG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9595:PTAFR
gene id: 9595:PTAFR
uniprot id: G3REF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9595:LIPC
gene id: 9595:LIPC
uniprot id: G3QYK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SLC39A12
gene id: 9595:SLC39A12
uniprot id: G3RHH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9595:TFAP2D
gene id: 9595:TFAP2D
uniprot id: G3QLT1
names: Similarity
messages: Belongs to the AP-2 family.

9595:ACAD11
gene id: 9595:ACAD11
uniprot id: G3RX63
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:CLCN5
gene id: 9595:CLCN5
uniprot id: A0A2I2Z3B1
uniprot id: G3RJX2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101130739
gene id: 9595:LOC101130739
uniprot id: G3RH94
names: Similarity
messages: Belongs to the peptidase M16 family.

9595:SLC22A2
gene id: 9595:SLC22A2
uniprot id: G3RCS0
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9595:SERPINB5
gene id: 9595:SERPINB5
uniprot id: G3RPE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9595:LOC115930092
gene id: 9595:LOC115930092
uniprot id: G3RDG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IK
gene id: 9595:IK
uniprot id: G3RC30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9595:APOO
gene id: 9595:APOO
uniprot id: G3QFV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9595:HNMT
gene id: 9595:HNMT
uniprot id: G3R7E5
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9595:G0S2
gene id: 9595:G0S2
uniprot id: A0A2I2Z078
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9595:ERBB2
gene id: 9595:ERBB2
uniprot id: G3QPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9595:TOP3B
gene id: 9595:TOP3B
uniprot id: G3S8S1
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9595:FABP2
gene id: 9595:FABP2
uniprot id: G3S5C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9595:SIX2
gene id: 9595:SIX2
uniprot id: G3QZU3
names: Subcellular Location Annotation
messages: Nucleus

9595:COPS5
gene id: 9595:COPS5
uniprot id: G3RJK0
uniprot id: G3SFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9595:HLF
gene id: 9595:HLF
uniprot id: G3QTC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9595:TSPAN14
gene id: 9595:TSPAN14
uniprot id: A0A2I2YKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:TUFM
gene id: 9595:TUFM
uniprot id: A0A2I2YVU5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9595:FAM53C
gene id: 9595:FAM53C
uniprot id: G3QEW6
names: Similarity
messages: Belongs to the FAM53 family.

9595:NSUN3
gene id: 9595:NSUN3
uniprot id: G3RBS6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9595:EFHC1
gene id: 9595:EFHC1
uniprot id: A0A2I2YWP3
uniprot id: G3S6D8
names: Subcellular Location Annotation
messages: cilium axoneme

9595:STING1
gene id: 9595:STING1
uniprot id: G3RJ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9595:AGPAT5
gene id: 9595:AGPAT5
uniprot id: G3S173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:FUT11
gene id: 9595:FUT11
uniprot id: G3QTL7
uniprot id: G3RPS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9595:URM1
gene id: 9595:URM1
uniprot id: A0A2I2YGW8
uniprot id: G3RFR8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9595:FAT2
gene id: 9595:FAT2
uniprot id: G3QU44
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CUL4B
gene id: 9595:CUL4B
uniprot id: A0A2I2ZLQ4
names: Similarity
messages: Belongs to the cullin family.

9595:NETO1
gene id: 9595:NETO1
uniprot id: G3RMS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CACNB4
gene id: 9595:CACNB4
uniprot id: A0A2I2Z399
uniprot id: A0A2I2Z7M7
uniprot id: A0A2I2Z8N3
uniprot id: A0A2I2ZP35
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9595:PPCS
gene id: 9595:PPCS
uniprot id: G3S9J8
names: Similarity
messages: Belongs to the PPC synthetase family.

9595:BRCC3
gene id: 9595:BRCC3
uniprot id: A0A2I2Y4Q6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9595:ST6GALNAC5
gene id: 9595:ST6GALNAC5
uniprot id: G3QRS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:DICER1
gene id: 9595:DICER1
uniprot id: G3QMF9
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9595:AVIL
gene id: 9595:AVIL
uniprot id: G3QGE5
names: Similarity
messages: Belongs to the villin/gelsolin family.

9595:ISCA2
gene id: 9595:ISCA2
uniprot id: G3SGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9595:NUS1
gene id: 9595:NUS1
uniprot id: G3SFP4
names: Similarity
messages: Belongs to the UPP synthase family.

9595:SDR9C7
gene id: 9595:SDR9C7
uniprot id: G3QYD0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SUPT4H1
gene id: 9595:SUPT4H1
uniprot id: G3QWC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9595:RHOT1
gene id: 9595:RHOT1
uniprot id: A0A2I2YSS3
uniprot id: A0A2I2ZEP6
uniprot id: G3SDU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9595:ETV1
gene id: 9595:ETV1
uniprot id: A0A2I2Y8B8
uniprot id: A0A2I2Z0A8
uniprot id: A0A2I2ZVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:ARVCF
gene id: 9595:ARVCF
uniprot id: G3QV08
names: Similarity
messages: Belongs to the beta-catenin family.

9595:IST1
gene id: 9595:IST1
uniprot id: A0A2I2Y7S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9595:TONSL
gene id: 9595:TONSL
uniprot id: G3RJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9595:CFLAR
gene id: 9595:CFLAR
uniprot id: G3R5V9
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:ALDH8A1
gene id: 9595:ALDH8A1
uniprot id: A0A2I2ZAD8
uniprot id: G3RI26
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:NKX3-1
gene id: 9595:NKX3-1
uniprot id: A0A2I2YFJ4
names: Subcellular Location Annotation
messages: Nucleus

9595:SGCA
gene id: 9595:SGCA
uniprot id: G3RBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton

9595:CACYBP
gene id: 9595:CACYBP
uniprot id: A0A2I2YIG0
uniprot id: A0A2I2Z4R9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9595:HSD17B10
gene id: 9595:HSD17B10
uniprot id: G3RYQ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:CIAPIN1
gene id: 9595:CIAPIN1
uniprot id: G3S917
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9595:CACNG3
gene id: 9595:CACNG3
uniprot id: G3QJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9595:RUNX3
gene id: 9595:RUNX3
uniprot id: G3S3J4
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9595:EGR2
gene id: 9595:EGR2
uniprot id: G3QRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9595:LRP12
gene id: 9595:LRP12
uniprot id: A0A2I2ZJH8
uniprot id: G3R8C7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:METTL4
gene id: 9595:METTL4
uniprot id: G3QF59
uniprot id: G3S474
names: Similarity
messages: Belongs to the MT-A70-like family.

9595:CRYBA1
gene id: 9595:CRYBA1
uniprot id: G3QIP2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:RPRM
gene id: 9595:RPRM
uniprot id: G3QIC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9595:GHRH
gene id: 9595:GHRH
uniprot id: G3QWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9595:DPY30
gene id: 9595:DPY30
uniprot id: A0A2I2YG65
names: Similarity
messages: Belongs to the dpy-30 family.

9595:WFDC12
gene id: 9595:WFDC12
uniprot id: A4K2R5
names: Function
names: Subcellular Location Annotation
messages: Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).
messages: Secreted

9595:ADGRL3
gene id: 9595:ADGRL3
uniprot id: A0A2I2Y9M5
names: Subcellular Location Annotation
messages: Membrane

9595:PLCB1
gene id: 9595:PLCB1
uniprot id: A0A2I2Y8M5
uniprot id: A0A2I2Z963
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9595:CD3D
gene id: 9595:CD3D
uniprot id: A0A2I2YH71
names: Subcellular Location Annotation
messages: Membrane

9595:PDIA6
gene id: 9595:PDIA6
uniprot id: G3QIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9595:PATL1
gene id: 9595:PATL1
uniprot id: G3QNX6
names: Similarity
messages: Belongs to the PAT1 family.

9595:PPIL3
gene id: 9595:PPIL3
uniprot id: G3SGD0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:LOC101146638
gene id: 9595:LOC101146638
uniprot id: G3QG39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:TMEM225B
gene id: 9595:TMEM225B
uniprot id: A0A2I2ZHR8
names: Subcellular Location Annotation
messages: Membrane

9595:ILDR2
gene id: 9595:ILDR2
uniprot id: G3QYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9595:NIPAL1
gene id: 9595:NIPAL1
uniprot id: A0A2I2YE80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9595:CAT
gene id: 9595:CAT
uniprot id: G3R538
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9595:NPAS4
gene id: 9595:NPAS4
uniprot id: G3QZU8
names: Subcellular Location Annotation
messages: Nucleus

9595:SCN1B
gene id: 9595:SCN1B
uniprot id: G3QQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9595:CAVIN2
gene id: 9595:CAVIN2
uniprot id: G3QGZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9595:SUSD4
gene id: 9595:SUSD4
uniprot id: G3QKJ9
uniprot id: G3S2K6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TNFSF14
gene id: 9595:TNFSF14
uniprot id: A0A2I2ZLT5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:ALKAL2
gene id: 9595:ALKAL2
uniprot id: G3REI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9595:LAMP5
gene id: 9595:LAMP5
uniprot id: G3RC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9595:FLNB
gene id: 9595:FLNB
uniprot id: G3R3J2
uniprot id: G3RYC3
names: Similarity
messages: Belongs to the filamin family.

9595:BMP3
gene id: 9595:BMP3
uniprot id: G3QR41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9595:ALG10B
gene id: 9595:ALG10B
uniprot id: G3QZC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

9595:TMEM106C
gene id: 9595:TMEM106C
uniprot id: G3QNU6
names: Similarity
messages: Belongs to the TMEM106 family.

9595:SLC12A8
gene id: 9595:SLC12A8
uniprot id: G3QRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:LOC101136413
gene id: 9595:LOC101136413
uniprot id: G3RLF1
names: Subcellular Location Annotation
messages: Membrane

9595:SERPINE2
gene id: 9595:SERPINE2
uniprot id: A0A2I2YS26
uniprot id: G3QF94
names: Similarity
messages: Belongs to the serpin family.

9595:FGF5
gene id: 9595:FGF5
uniprot id: A0A2I2YYH7
uniprot id: G3QKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9595:PRNP
gene id: 9595:PRNP
uniprot id: P40252
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1 (By similarity). Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with APP. Interacts with KIAA1191 (By similarity). Interacts with ADGRG6 (By similarity).
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9595:FOXP4
gene id: 9595:FOXP4
uniprot id: G3RJT8
names: Subcellular Location Annotation
messages: Nucleus

9595:TM9SF1
gene id: 9595:TM9SF1
uniprot id: G3RJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9595:NSG1
gene id: 9595:NSG1
uniprot id: G3R690
names: Similarity
messages: Belongs to the NSG family.

9595:TARBP2
gene id: 9595:TARBP2
uniprot id: G3RA71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9595:GLB1
gene id: 9595:GLB1
uniprot id: A0A2I2ZE55
uniprot id: G3RIA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9595:MARCO
gene id: 9595:MARCO
uniprot id: G3RHS7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CHN1
gene id: 9595:CHN1
uniprot id: G3SBI9
names: Function
messages: GTPase-activating protein for p21-rac.

9595:TOP2A
gene id: 9595:TOP2A
uniprot id: G3S3V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9595:LOC101135415
gene id: 9595:LOC101135415
uniprot id: A0A2I2Y4B6
names: Subcellular Location Annotation
messages: Nucleus

9595:KCNC4
gene id: 9595:KCNC4
uniprot id: G3SH62
names: Subcellular Location Annotation
messages: Membrane

9595:HCFC2
gene id: 9595:HCFC2
uniprot id: A0A2I2YK61
names: Subcellular Location Annotation
messages: Nucleus

9595:SNRPC
gene id: 9595:SNRPC
uniprot id: G3R9U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9595:MASTL
gene id: 9595:MASTL
uniprot id: G3RKT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9595:HCRTR1
gene id: 9595:HCRTR1
uniprot id: G3RIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ARR3
gene id: 9595:ARR3
uniprot id: G3QUR5
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

9595:ZNF213
gene id: 9595:ZNF213
uniprot id: G3R8L7
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101135098
gene id: 9595:LOC101135098
uniprot id: A0A2I2YG23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:NUF2
gene id: 9595:NUF2
uniprot id: G3QY78
names: Similarity
messages: Belongs to the NUF2 family.

9595:P2RX1
gene id: 9595:P2RX1
uniprot id: G3S4B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9595:MRPL36
gene id: 9595:MRPL36
uniprot id: G3RLA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9595:CKAP5
gene id: 9595:CKAP5
uniprot id: A0A2I2Z6B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9595:LOC101150557
gene id: 9595:LOC101150557
uniprot id: G3RZ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:PIP4P1
gene id: 9595:PIP4P1
uniprot id: G3QI92
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9595:NPC2
gene id: 9595:NPC2
uniprot id: G3RAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9595:FAM241A
gene id: 9595:FAM241A
uniprot id: G3RQY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9595:PSMA7
gene id: 9595:PSMA7
uniprot id: G3QS87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:PIK3CG
gene id: 9595:PIK3CG
uniprot id: G3S7D1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:TP53I11
gene id: 9595:TP53I11
uniprot id: A0A2I2YBP2
names: Subcellular Location Annotation
messages: Membrane

9595:DOCK8
gene id: 9595:DOCK8
uniprot id: A0A2I2Z9P1
uniprot id: G3R0C4
names: Similarity
messages: Belongs to the DOCK family.

9595:TSPAN7
gene id: 9595:TSPAN7
uniprot id: A0A2I2Z7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:HMGA2
gene id: 9595:HMGA2
uniprot id: A0A2I2YMA3
uniprot id: A0A2I2YYG6
uniprot id: A0A2I2ZE73
uniprot id: A0A2I2ZTF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9595:FGD3
gene id: 9595:FGD3
uniprot id: A0A2I2YN64
uniprot id: G3R0M3
names: Subcellular Location Annotation
messages: cytoskeleton

9595:PSMC2
gene id: 9595:PSMC2
uniprot id: G3R1A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9595:FGF14
gene id: 9595:FGF14
uniprot id: A0A2I2Y2V3
uniprot id: G3QVB3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:HMGA1
gene id: 9595:HMGA1
uniprot id: G3SHP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
messages: Interacts with HIPK2.
messages: Nucleus

9595:IMPG2
gene id: 9595:IMPG2
uniprot id: G3RJ49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9595:TMEM211
gene id: 9595:TMEM211
uniprot id: A0A2I2Y928
names: Subcellular Location Annotation
messages: Membrane

9595:KIF12
gene id: 9595:KIF12
uniprot id: G3RE82
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:SSR2
gene id: 9595:SSR2
uniprot id: G3S0V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9595:ZSCAN4
gene id: 9595:ZSCAN4
uniprot id: G3QRD7
names: Subcellular Location Annotation
messages: Nucleus

9595:SMPDL3B
gene id: 9595:SMPDL3B
uniprot id: G3RG15
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9595:VAMP8
gene id: 9595:VAMP8
uniprot id: G3QQI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:TNFSF15
gene id: 9595:TNFSF15
uniprot id: G3R5G8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:TMEM126B
gene id: 9595:TMEM126B
uniprot id: A0A2I2Y8T2
uniprot id: G3QI97
names: Subcellular Location Annotation
messages: Membrane

9595:SLC25A45
gene id: 9595:SLC25A45
uniprot id: A0A2I2YQ03
uniprot id: A0A2I2Z1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:RAD21L1
gene id: 9595:RAD21L1
uniprot id: G3RQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9595:PRDM5
gene id: 9595:PRDM5
uniprot id: A0A2I2YGF8
uniprot id: A0A2I2ZNF0
names: Subcellular Location Annotation
messages: Nucleus

9595:RRH
gene id: 9595:RRH
uniprot id: G3RNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:TFIP11
gene id: 9595:TFIP11
uniprot id: G3QQN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9595:STAC
gene id: 9595:STAC
uniprot id: G3RCH3
names: Subcellular Location Annotation
messages: sarcolemma

9595:TEC
gene id: 9595:TEC
uniprot id: G3RRV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9595:BCL2
gene id: 9595:BCL2
uniprot id: G3QES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9595:XAGE2
gene id: 9595:XAGE2
uniprot id: G3S4Q2
names: Similarity
messages: Belongs to the GAGE family.

9595:MSH2
gene id: 9595:MSH2
uniprot id: G3QW00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9595:MRPL30
gene id: 9595:MRPL30
uniprot id: A0A2I2YL41
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9595:MRPL18
gene id: 9595:MRPL18
uniprot id: G3RDW2
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9595:SGTB
gene id: 9595:SGTB
uniprot id: G3S4B3
names: Similarity
messages: Belongs to the SGT family.

9595:KCNA10
gene id: 9595:KCNA10
uniprot id: G3QZB3
names: Subcellular Location Annotation
messages: Membrane

9595:PTGER2
gene id: 9595:PTGER2
uniprot id: G3R8I2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:CNOT2
gene id: 9595:CNOT2
uniprot id: A0A2I2YKY8
uniprot id: A0A2I2YMV9
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9595:YIF1B
gene id: 9595:YIF1B
uniprot id: A0A2I2YFZ0
uniprot id: A0A2I2ZK95
uniprot id: G3RDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9595:GPBP1
gene id: 9595:GPBP1
uniprot id: G3QZA0
uniprot id: G3S8V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9595:DNAAF1
gene id: 9595:DNAAF1
uniprot id: G3RM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

9595:FBXO32
gene id: 9595:FBXO32
uniprot id: G3QKF2
names: Subcellular Location Annotation
messages: Nucleus

9595:E2F6
gene id: 9595:E2F6
uniprot id: A0A2I2Y8N4
uniprot id: G3RUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:HSPA4
gene id: 9595:HSPA4
uniprot id: A0A2I2Y3A1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9595:POC5
gene id: 9595:POC5
uniprot id: G3RGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

9595:MTIF2
gene id: 9595:MTIF2
uniprot id: G3QXH7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9595:CLEC4M
gene id: 9595:CLEC4M
uniprot id: Q8HY06
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Membrane
messages: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
messages: The tandem repeat domain, also called neck domain, mediates oligomerization.

9595:CTNNAL1
gene id: 9595:CTNNAL1
uniprot id: G3QNN9
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9595:HM13
gene id: 9595:HM13
uniprot id: G3QFB0
uniprot id: G3S6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9595:SLC1A3
gene id: 9595:SLC1A3
uniprot id: G3QPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:MAP3K8
gene id: 9595:MAP3K8
uniprot id: G3QS35
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9595:SEC22A
gene id: 9595:SEC22A
uniprot id: A0A2I2Z5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9595:MOCS1
gene id: 9595:MOCS1
uniprot id: G3R0Q1
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9595:FOXN4
gene id: 9595:FOXN4
uniprot id: G3R1N1
names: Subcellular Location Annotation
messages: Nucleus

9595:CHRDL2
gene id: 9595:CHRDL2
uniprot id: G3SB86
names: Subcellular Location Annotation
messages: Secreted

9595:SLC37A2
gene id: 9595:SLC37A2
uniprot id: G3RHQ0
uniprot id: G3RTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9595:PIN4
gene id: 9595:PIN4
uniprot id: G3RIU6
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9595:SGMS2
gene id: 9595:SGMS2
uniprot id: G3RA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9595:SMARCA5
gene id: 9595:SMARCA5
uniprot id: G3SF21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9595:PMPCB
gene id: 9595:PMPCB
uniprot id: A0A2I2ZSW3
uniprot id: G3S5I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9595:GLUD2
gene id: 9595:GLUD2
uniprot id: A0A2I2ZHL0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9595:CHAF1B
gene id: 9595:CHAF1B
uniprot id: G3RI54
names: Subcellular Location Annotation
messages: Nucleus

9595:CSF3
gene id: 9595:CSF3
uniprot id: A0A2I2Y806
uniprot id: G3QQS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

9595:ELP3
gene id: 9595:ELP3
uniprot id: G3QQ56
uniprot id: G3RPT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9595:LYRM7
gene id: 9595:LYRM7
uniprot id: G3R8G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9595:PDS5A
gene id: 9595:PDS5A
uniprot id: G3QWM7
names: Similarity
messages: Belongs to the PDS5 family.

9595:LIPK
gene id: 9595:LIPK
uniprot id: G3QKZ9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:MFF
gene id: 9595:MFF
uniprot id: A0A2I2Y495
uniprot id: A0A2I2YR37
uniprot id: A0A2I2YW07
uniprot id: A0A2I2ZM93
uniprot id: G3RL80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9595:NDUFS5
gene id: 9595:NDUFS5
uniprot id: Q0MQH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9595:LOC109023730
gene id: 9595:LOC109023730
uniprot id: G3RSH0
names: Similarity
messages: Belongs to the ATG8 family.

9595:RSL24D1
gene id: 9595:RSL24D1
uniprot id: G3QR54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9595:S1PR3
gene id: 9595:S1PR3
uniprot id: A0A2I2YLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:SLC49A3
gene id: 9595:SLC49A3
uniprot id: G3QSJ0
names: Subcellular Location Annotation
messages: Membrane

9595:PGPEP1L
gene id: 9595:PGPEP1L
uniprot id: A0A2I2ZSI4
uniprot id: G3QTS1
names: Similarity
messages: Belongs to the peptidase C15 family.

9595:ARSB
gene id: 9595:ARSB
uniprot id: A0A2I2YTP9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:DMC1
gene id: 9595:DMC1
uniprot id: A0A2I2YX58
uniprot id: G3R6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9595:S100A4
gene id: 9595:S100A4
uniprot id: G3QWC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9595:BCAP29
gene id: 9595:BCAP29
uniprot id: G3SAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9595:PIGH
gene id: 9595:PIGH
uniprot id: G3QGM9
names: Similarity
messages: Belongs to the PIGH family.

9595:GRM3
gene id: 9595:GRM3
uniprot id: G3RH49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9595:ARMC1
gene id: 9595:ARMC1
uniprot id: G3RPG2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9595:DLK2
gene id: 9595:DLK2
uniprot id: G3QZU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PFN4
gene id: 9595:PFN4
uniprot id: G3RUG6
names: Similarity
messages: Belongs to the profilin family.

9595:ZNF622
gene id: 9595:ZNF622
uniprot id: G3RSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9595:GPAT3
gene id: 9595:GPAT3
uniprot id: G3QNL4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:CMC1
gene id: 9595:CMC1
uniprot id: A0A2I2Y7L1
uniprot id: G3R9L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9595:TRIM54
gene id: 9595:TRIM54
uniprot id: A0A2I2Z362
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9595:ATP1A1
gene id: 9595:ATP1A1
uniprot id: G3RZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9595:CXCR5
gene id: 9595:CXCR5
uniprot id: G3RDW5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:FGF16
gene id: 9595:FGF16
uniprot id: G3QIJ1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:HTR7
gene id: 9595:HTR7
uniprot id: A0A2I2Z5A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101144859
gene id: 9595:LOC101144859
uniprot id: G3QXY3
names: Subcellular Location Annotation
messages: Membrane

9595:DGUOK
gene id: 9595:DGUOK
uniprot id: G3QN24
uniprot id: G3SIQ2
names: Similarity
messages: Belongs to the DCK/DGK family.

9595:UBE2D3
gene id: 9595:UBE2D3
uniprot id: A0A2I2Z6N8
uniprot id: G3QG99
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:TMEM59L
gene id: 9595:TMEM59L
uniprot id: G3RSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:LIM2
gene id: 9595:LIM2
uniprot id: G3RFP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9595:CASQ1
gene id: 9595:CASQ1
uniprot id: G3RFB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9595:NDST1
gene id: 9595:NDST1
uniprot id: G3RCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:TEX13B
gene id: 9595:TEX13B
uniprot id: G3S1W7
names: Similarity
messages: Belongs to the TEX13 family.

9595:PGAP3
gene id: 9595:PGAP3
uniprot id: A0A2I2YFK6
uniprot id: A0A2I2ZIR1
uniprot id: G3SAB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MEP1B
gene id: 9595:MEP1B
uniprot id: G3SF75
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SUCLG2
gene id: 9595:SUCLG2
uniprot id: A0A2I2Y602
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9595:SLC35F4
gene id: 9595:SLC35F4
uniprot id: A0A2I2YY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9595:ELOVL1
gene id: 9595:ELOVL1
uniprot id: G3R4H1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9595:PDIA2
gene id: 9595:PDIA2
uniprot id: G3R2R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9595:PPP2R5D
gene id: 9595:PPP2R5D
uniprot id: G3QWE9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9595:TSEN2
gene id: 9595:TSEN2
uniprot id: A0A2I2Z8W2
uniprot id: G3R9T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9595:VCAN
gene id: 9595:VCAN
uniprot id: A0A2I2YZ66
uniprot id: A0A2I2Z3I6
uniprot id: G3RJ07
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:CMTM8
gene id: 9595:CMTM8
uniprot id: G3QT92
names: Subcellular Location Annotation
messages: Membrane

9595:HSDL2
gene id: 9595:HSDL2
uniprot id: G3S6V2
names: Subcellular Location Annotation
messages: Peroxisome

9595:TGFB2
gene id: 9595:TGFB2
uniprot id: A0A2I2ZKR7
uniprot id: G3QPK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9595:SIRT4
gene id: 9595:SIRT4
uniprot id: G3SBZ3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9595:HABP4
gene id: 9595:HABP4
uniprot id: G3R9D8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:LOC101154356
gene id: 9595:LOC101154356
uniprot id: G3RAC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9595:TM4SF4
gene id: 9595:TM4SF4
uniprot id: G3QHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:GNGT1
gene id: 9595:GNGT1
uniprot id: G3RGF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:LOC101128649
gene id: 9595:LOC101128649
uniprot id: G3QNM6
names: Subcellular Location Annotation
messages: Membrane

9595:RHCG
gene id: 9595:RHCG
uniprot id: G3RHG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9595:INTS3
gene id: 9595:INTS3
uniprot id: G3RTH1
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9595:PI4K2A
gene id: 9595:PI4K2A
uniprot id: G3RGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9595:CTBS
gene id: 9595:CTBS
uniprot id: G3RI64
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

9595:LIMS2
gene id: 9595:LIMS2
uniprot id: A0A2I2ZTS6
uniprot id: G3QPZ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9595:ACSS3
gene id: 9595:ACSS3
uniprot id: G3R3N2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:SUOX
gene id: 9595:SUOX
uniprot id: G3RXF0
names: Function
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.

9595:LOC101143897
gene id: 9595:LOC101143897
uniprot id: G3S4X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MTERF2
gene id: 9595:MTERF2
uniprot id: G3RX35
names: Similarity
messages: Belongs to the mTERF family.

9595:RPGRIP1L
gene id: 9595:RPGRIP1L
uniprot id: G3RSN7
names: Similarity
messages: Belongs to the RPGRIP1 family.

9595:TMEM41A
gene id: 9595:TMEM41A
uniprot id: A0A2I2YZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9595:WDR4
gene id: 9595:WDR4
uniprot id: G3RKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9595:MOB3B
gene id: 9595:MOB3B
uniprot id: G3QPL3
names: Similarity
messages: Belongs to the MOB1/phocein family.

9595:DHRS11
gene id: 9595:DHRS11
uniprot id: A0A2I2YLK8
uniprot id: G3QY64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:MAST3
gene id: 9595:MAST3
uniprot id: G3SJ61
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9595:ATG101
gene id: 9595:ATG101
uniprot id: G3QU82
names: Similarity
messages: Belongs to the ATG101 family.

9595:AMPD1
gene id: 9595:AMPD1
uniprot id: A0A2I2YPD9
uniprot id: G3RD73
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9595:ATP7B
gene id: 9595:ATP7B
uniprot id: G3RTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9595:SPG7
gene id: 9595:SPG7
uniprot id: G3RVG4
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9595:ACAN
gene id: 9595:ACAN
uniprot id: G3QRB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:CCN1
gene id: 9595:CCN1
uniprot id: G3QVP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SCGB1D1
gene id: 9595:SCGB1D1
uniprot id: G3RI14
names: Subcellular Location Annotation
messages: Secreted

9595:TIMP4
gene id: 9595:TIMP4
uniprot id: G3R2S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9595:GIP
gene id: 9595:GIP
uniprot id: G3SCT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9595:LOC101144267
gene id: 9595:LOC101144267
uniprot id: G3RDL7
names: Subcellular Location Annotation
messages: Membrane

9595:UXS1
gene id: 9595:UXS1
uniprot id: G3SKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9595:ADGRV1
gene id: 9595:ADGRV1
uniprot id: G3R5Z0
names: Subcellular Location Annotation
messages: Membrane

9595:PRPS1
gene id: 9595:PRPS1
uniprot id: G3R9N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9595:ATP6V1F
gene id: 9595:ATP6V1F
uniprot id: G3RZ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:LGR6
gene id: 9595:LGR6
uniprot id: G3QSR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:COG7
gene id: 9595:COG7
uniprot id: G3QGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:FERMT3
gene id: 9595:FERMT3
uniprot id: G3R8Y5
names: Similarity
messages: Belongs to the kindlin family.

9595:COQ10A
gene id: 9595:COQ10A
uniprot id: G3R133
uniprot id: G3S4I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9595:PSMG2
gene id: 9595:PSMG2
uniprot id: G3R3J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9595:KIFC1
gene id: 9595:KIFC1
uniprot id: G3QDE3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:UBB
gene id: 9595:UBB
uniprot id: P0CG67
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.
messages: Mitochondrion outer membrane
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9595:GADD45GIP1
gene id: 9595:GADD45GIP1
uniprot id: G3RS84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9595:ASXL1
gene id: 9595:ASXL1
uniprot id: G3S371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9595:CD99L2
gene id: 9595:CD99L2
uniprot id: A0A2I2YBL0
uniprot id: G3RN63
names: Similarity
messages: Belongs to the CD99 family.

9595:ARHGEF11
gene id: 9595:ARHGEF11
uniprot id: G3RG84
uniprot id: G3SDF2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9595:USP21
gene id: 9595:USP21
uniprot id: G3QX09
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:PADI4
gene id: 9595:PADI4
uniprot id: G3RGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:UCP1
gene id: 9595:UCP1
uniprot id: G3RQZ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9595:NIBAN3
gene id: 9595:NIBAN3
uniprot id: G3R801
uniprot id: G3RZK1
names: Similarity
messages: Belongs to the Niban family.

9595:ELF1
gene id: 9595:ELF1
uniprot id: G3R5C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:MPEG1
gene id: 9595:MPEG1
uniprot id: G3R8Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:NDST2
gene id: 9595:NDST2
uniprot id: G3QTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:RAD52
gene id: 9595:RAD52
uniprot id: G3QUD4
names: Similarity
messages: Belongs to the RAD52 family.

9595:TAF1B
gene id: 9595:TAF1B
uniprot id: G3QJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9595:NT5C2
gene id: 9595:NT5C2
uniprot id: G3RSZ5
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9595:TGFBI
gene id: 9595:TGFBI
uniprot id: G3R261
names: Subcellular Location Annotation
messages: extracellular matrix

9595:IL36G
gene id: 9595:IL36G
uniprot id: A0A2I2YJY8
uniprot id: G3RIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9595:IMPAD1
gene id: 9595:IMPAD1
uniprot id: G3RPL5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9595:LOC101125649
gene id: 9595:LOC101125649
uniprot id: A0A2I2YP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PPM1D
gene id: 9595:PPM1D
uniprot id: G3R0Z4
names: Similarity
messages: Belongs to the PP2C family.

9595:RNASE11
gene id: 9595:RNASE11
uniprot id: A0A2I2ZB58
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9595:RIPK2
gene id: 9595:RIPK2
uniprot id: G3R5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9595:PHACTR3
gene id: 9595:PHACTR3
uniprot id: A0A2I2YCF8
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9595:LOC101128005
gene id: 9595:LOC101128005
uniprot id: G3RHE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:TIMM21
gene id: 9595:TIMM21
uniprot id: G3RIN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9595:NFYA
gene id: 9595:NFYA
uniprot id: A0A2I2Z8C6
uniprot id: G3QZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9595:ABCG5
gene id: 9595:ABCG5
uniprot id: G3QEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:LOC101127173
gene id: 9595:LOC101127173
uniprot id: G3QE29
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:PKD1L3
gene id: 9595:PKD1L3
uniprot id: G3QY83
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101149205
gene id: 9595:LOC101149205
uniprot id: G3QL69
names: Subcellular Location Annotation
messages: Membrane

9595:BPIFA1
gene id: 9595:BPIFA1
uniprot id: G3SGJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Secreted

9595:LOC101128459
gene id: 9595:LOC101128459
uniprot id: G3S348
names: Subunit
messages: Interacts with hair keratins.

9595:ZZZ3
gene id: 9595:ZZZ3
uniprot id: G3R1G6
names: Subcellular Location Annotation
messages: Nucleus

9595:PLA2G4F
gene id: 9595:PLA2G4F
uniprot id: G3S105
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9595:NCSTN
gene id: 9595:NCSTN
uniprot id: G3QLU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9595:BBS2
gene id: 9595:BBS2
uniprot id: G3RIZ2
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9595:UTS2B
gene id: 9595:UTS2B
uniprot id: G3SKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9595:TRHDE
gene id: 9595:TRHDE
uniprot id: G3R602
names: Similarity
messages: Belongs to the peptidase M1 family.

9595:CDK8
gene id: 9595:CDK8
uniprot id: G3QUM8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:PCNX2
gene id: 9595:PCNX2
uniprot id: G3SKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9595:XAGE5
gene id: 9595:XAGE5
uniprot id: G3QWF7
names: Similarity
messages: Belongs to the GAGE family.

9595:LOC101129087
gene id: 9595:LOC101129087
uniprot id: G3R3C3
names: Similarity
messages: Belongs to the NUT family.

9595:CPSF6
gene id: 9595:CPSF6
uniprot id: A0A2I2YN73
uniprot id: G3SJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

9595:POLR2F
gene id: 9595:POLR2F
uniprot id: A0A2I2ZC79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9595:FUT10
gene id: 9595:FUT10
uniprot id: G3RYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9595:ZW10
gene id: 9595:ZW10
uniprot id: G3RUL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9595:NAGK
gene id: 9595:NAGK
uniprot id: G3RVS8
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9595:ART5
gene id: 9595:ART5
uniprot id: G3RVV6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9595:HAPLN4
gene id: 9595:HAPLN4
uniprot id: G3QKF6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MRPL15
gene id: 9595:MRPL15
uniprot id: G3R4E8
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9595:ZNF446
gene id: 9595:ZNF446
uniprot id: A0A2I2ZEU4
names: Subcellular Location Annotation
messages: Nucleus

9595:AJAP1
gene id: 9595:AJAP1
uniprot id: A0A2I2ZN79
names: Subcellular Location Annotation
messages: Membrane

9595:FLOT1
gene id: 9595:FLOT1
uniprot id: G3QIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9595:PRKCH
gene id: 9595:PRKCH
uniprot id: G3QZ70
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9595:TMCC3
gene id: 9595:TMCC3
uniprot id: A0A2I2YCT7
uniprot id: G3QX43
names: Similarity
messages: Belongs to the TEX28 family.

9595:SFMBT1
gene id: 9595:SFMBT1
uniprot id: G3QSK5
names: Subcellular Location Annotation
messages: Nucleus

9595:RABAC1
gene id: 9595:RABAC1
uniprot id: G3QMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9595:AOC2
gene id: 9595:AOC2
uniprot id: G3QY85
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9595:SHTN1
gene id: 9595:SHTN1
uniprot id: A0A2I2YTM9
uniprot id: G3SI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9595:TMED6
gene id: 9595:TMED6
uniprot id: G3QXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:RWDD3
gene id: 9595:RWDD3
uniprot id: A0A2I2ZN15
uniprot id: G3RYE8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:CAV2
gene id: 9595:CAV2
uniprot id: A0A2I2ZU14
uniprot id: Q2IBF3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
messages: Membrane
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).
messages: caveola

9595:EIF3L
gene id: 9595:EIF3L
uniprot id: A0A2I2ZBL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9595:LOC101146261
gene id: 9595:LOC101146261
uniprot id: G3RNU8
names: Similarity
messages: Belongs to the globin family.

9595:NRN1
gene id: 9595:NRN1
uniprot id: G3QR76
names: Similarity
messages: Belongs to the neuritin family.

9595:FOXJ3
gene id: 9595:FOXJ3
uniprot id: A0A2I2YRH3
uniprot id: G3RCQ2
names: Subcellular Location Annotation
messages: Nucleus

9595:DUSP9
gene id: 9595:DUSP9
uniprot id: G3RGY6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:INPP5B
gene id: 9595:INPP5B
uniprot id: A0A2I2ZWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9595:OPALIN
gene id: 9595:OPALIN
uniprot id: A0A2I2ZRR1
uniprot id: G3QF24
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9595:RPN2
gene id: 9595:RPN2
uniprot id: G3SJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9595:HOXB7
gene id: 9595:HOXB7
uniprot id: A1YFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family.
messages: Forms a DNA-binding heterodimer with transcription factor PBX1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:DERL2
gene id: 9595:DERL2
uniprot id: A0A2I2YCV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LAMTOR4
gene id: 9595:LAMTOR4
uniprot id: G3S8H2
names: Similarity
messages: Belongs to the LAMTOR4 family.

9595:MSMB
gene id: 9595:MSMB
uniprot id: G3RFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9595:CHD3
gene id: 9595:CHD3
uniprot id: G3RCF2
uniprot id: G3SAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9595:CLEC12B
gene id: 9595:CLEC12B
uniprot id: G3R0F9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:PLOD2
gene id: 9595:PLOD2
uniprot id: A0A2I2YIY7
uniprot id: G3REF3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9595:TFE3
gene id: 9595:TFE3
uniprot id: A0A2I2YS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9595:DBNDD2
gene id: 9595:DBNDD2
uniprot id: A0A2I2Z6B0
names: Similarity
messages: Belongs to the dysbindin family.

9595:LDHC
gene id: 9595:LDHC
uniprot id: A0A2I2YN53
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:NUP58
gene id: 9595:NUP58
uniprot id: A0A2I2YV67
uniprot id: G3QM84
names: Subcellular Location Annotation
messages: nuclear pore complex

9595:PTH2R
gene id: 9595:PTH2R
uniprot id: G3RLB1
names: Subcellular Location Annotation
messages: Membrane

9595:CENPJ
gene id: 9595:CENPJ
uniprot id: A0A2I2ZCY6
uniprot id: G3RF23
names: Similarity
messages: Belongs to the TCP10 family.

9595:SFRP2
gene id: 9595:SFRP2
uniprot id: G3QH51
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PPP1R15B
gene id: 9595:PPP1R15B
uniprot id: G3QG83
names: Similarity
messages: Belongs to the PPP1R15 family.

9595:DPF2
gene id: 9595:DPF2
uniprot id: G3S920
names: Similarity
messages: Belongs to the requiem/DPF family.

9595:PSMD4
gene id: 9595:PSMD4
uniprot id: G3QN77
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9595:LOC101135184
gene id: 9595:LOC101135184
uniprot id: G3SK93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CC2D1B
gene id: 9595:CC2D1B
uniprot id: G3QD75
uniprot id: G3SJN8
names: Similarity
messages: Belongs to the CC2D1 family.

9595:CPA5
gene id: 9595:CPA5
uniprot id: G3QJ01
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:RIPPLY1
gene id: 9595:RIPPLY1
uniprot id: A0A2I2ZMB4
uniprot id: G3QRS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9595:LOC101142418
gene id: 9595:LOC101142418
uniprot id: G3RC58
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:ADAM30
gene id: 9595:ADAM30
uniprot id: G3QN27
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DCLRE1C
gene id: 9595:DCLRE1C
uniprot id: A0A2I2YGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9595:WBP4
gene id: 9595:WBP4
uniprot id: G3SGZ3
names: Subcellular Location Annotation
messages: Nucleus

9595:GRIN2B
gene id: 9595:GRIN2B
uniprot id: G3R3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9595:HCAR1
gene id: 9595:HCAR1
uniprot id: A0A2I2YNR0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:LOC101142758
gene id: 9595:LOC101142758
uniprot id: G3QK98
uniprot id: G3S973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9595:LMOD3
gene id: 9595:LMOD3
uniprot id: G3RLZ9
names: Subcellular Location Annotation
messages: cytoskeleton

9595:AGRP
gene id: 9595:AGRP
uniprot id: G3RB26
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:PRSS12
gene id: 9595:PRSS12
uniprot id: G3QK11
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9595:LOC101125083
gene id: 9595:LOC101125083
uniprot id: A0A2I2ZAH3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9595:KRT36
gene id: 9595:KRT36
uniprot id: G3RL32
names: Similarity
messages: Belongs to the intermediate filament family.

9595:CNTFR
gene id: 9595:CNTFR
uniprot id: G3QUF2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9595:CCNA1
gene id: 9595:CCNA1
uniprot id: G3SD32
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9595:MGAT4A
gene id: 9595:MGAT4A
uniprot id: G3RZE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:SEC62
gene id: 9595:SEC62
uniprot id: G3RCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:GK5
gene id: 9595:GK5
uniprot id: G3QM69
names: Similarity
messages: Belongs to the FGGY kinase family.

9595:NFIL3
gene id: 9595:NFIL3
uniprot id: G3QG48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9595:ZNF394
gene id: 9595:ZNF394
uniprot id: G3RCS9
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101139836
gene id: 9595:LOC101139836
uniprot id: G3RDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9595:LOC109023047
gene id: 9595:LOC109023047
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:MRPL19
gene id: 9595:MRPL19
uniprot id: A0A2I2Z2F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9595:HK3
gene id: 9595:HK3
uniprot id: G3QI72
names: Similarity
messages: Belongs to the hexokinase family.

9595:CLDN2
gene id: 9595:CLDN2
uniprot id: A0A2I2Y2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:TMEM38B
gene id: 9595:TMEM38B
uniprot id: A0A2I2YFB8
uniprot id: G3QWA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9595:NSFL1C
gene id: 9595:NSFL1C
uniprot id: G3RCH7
uniprot id: G3SJI5
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9595:APAF1
gene id: 9595:APAF1
uniprot id: A0A2I2YKE3
uniprot id: A0A2I2ZPS0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9595:RNASEH1
gene id: 9595:RNASEH1
uniprot id: G3SKF3
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9595:PPP3CA
gene id: 9595:PPP3CA
uniprot id: A0A2I2YDT1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9595:MAP7D3
gene id: 9595:MAP7D3
uniprot id: A0A2I2YJK5
names: Similarity
messages: Belongs to the MAP7 family.

9595:SPI1
gene id: 9595:SPI1
uniprot id: G3QUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:LOC101138131
gene id: 9595:LOC101138131
uniprot id: G3RD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SAP30L
gene id: 9595:SAP30L
uniprot id: G3QP70
names: Similarity
messages: Belongs to the SAP30 family.

9595:SLC43A3
gene id: 9595:SLC43A3
uniprot id: G3R2Y0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC12A6
gene id: 9595:SLC12A6
uniprot id: A0A2I2YSB0
uniprot id: A0A2I2Z741
uniprot id: A0A2I2ZT44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:MT4
gene id: 9595:MT4
uniprot id: G3QR55
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:CAPRIN2
gene id: 9595:CAPRIN2
uniprot id: A0A2I2Z5V8
uniprot id: G3QTM9
names: Similarity
messages: Belongs to the caprin family.

9595:LDLRAD3
gene id: 9595:LDLRAD3
uniprot id: G3RKF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:STIM1
gene id: 9595:STIM1
uniprot id: G3RE38
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ADD2
gene id: 9595:ADD2
uniprot id: A0A2I2YDZ2
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9595:CAV1
gene id: 9595:CAV1
uniprot id: A0A2K5TIY4
uniprot id: Q2IBF0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9595:PSAT1
gene id: 9595:PSAT1
uniprot id: G3SJS7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9595:LTBR
gene id: 9595:LTBR
uniprot id: G3R5J9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MS4A3
gene id: 9595:MS4A3
uniprot id: A0A2I2Z0V5
uniprot id: G3QGD1
names: Similarity
messages: Belongs to the MS4A family.

9595:PMM2
gene id: 9595:PMM2
uniprot id: G3R3Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9595:REM1
gene id: 9595:REM1
uniprot id: G3QFA9
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9595:ASB15
gene id: 9595:ASB15
uniprot id: G3QZR9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:FAM120B
gene id: 9595:FAM120B
uniprot id: G3RUA5
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9595:IL7
gene id: 9595:IL7
uniprot id: A0A2I2Y631
uniprot id: A0A2I2YQZ9
uniprot id: A0A2I2YTF7
uniprot id: A0A2I2YTW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9595:LPAR3
gene id: 9595:LPAR3
uniprot id: G3R648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC9A7
gene id: 9595:SLC9A7
uniprot id: G3R0D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9595:RNF40
gene id: 9595:RNF40
uniprot id: G3RKQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9595:XRN2
gene id: 9595:XRN2
uniprot id: G3SD30
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9595:NR4A2
gene id: 9595:NR4A2
uniprot id: G3R6F3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9595:RPL18A
gene id: 9595:RPL18A
uniprot id: G3QK54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9595:ATL1
gene id: 9595:ATL1
uniprot id: A0A2I2Z073
uniprot id: G3S4S5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:SLC6A13
gene id: 9595:SLC6A13
uniprot id: A0A2I2ZMV3
uniprot id: G3QQD1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9595:CTBP2
gene id: 9595:CTBP2
uniprot id: A0A2I2ZSE0
uniprot id: G3S0L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9595:HSF4
gene id: 9595:HSF4
uniprot id: G3R8A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9595:ANKRD13D
gene id: 9595:ANKRD13D
uniprot id: G3R6R1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9595:LOC101135881
gene id: 9595:LOC101135881
uniprot id: G3QNG6
names: Subcellular Location Annotation
messages: Membrane

9595:PIGP
gene id: 9595:PIGP
uniprot id: G3R440
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9595:SGCG
gene id: 9595:SGCG
uniprot id: G3REE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9595:TAS2R7
gene id: 9595:TAS2R7
uniprot id: G3S7B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9595:ABRAXAS1
gene id: 9595:ABRAXAS1
uniprot id: G3QSQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9595:PPP1R11
gene id: 9595:PPP1R11
uniprot id: G3RNA2
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9595:CRIPT
gene id: 9595:CRIPT
uniprot id: G3RGF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9595:MUC13
gene id: 9595:MUC13
uniprot id: G3QDU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TNFAIP1
gene id: 9595:TNFAIP1
uniprot id: G3QPI7
names: Similarity
messages: Belongs to the BACURD family.

9595:MCOLN3
gene id: 9595:MCOLN3
uniprot id: G3QWU1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:TRIAP1
gene id: 9595:TRIAP1
uniprot id: G3RR18
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9595:HOXC11
gene id: 9595:HOXC11
uniprot id: G3SBM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9595:LOC101126098
gene id: 9595:LOC101126098
uniprot id: G3QKC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PITX1
gene id: 9595:PITX1
uniprot id: G3QQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9595:DARS1
gene id: 9595:DARS1
uniprot id: A0A2I2Y6L3
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9595:B3GAT2
gene id: 9595:B3GAT2
uniprot id: G3S6M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:ANKRD34C
gene id: 9595:ANKRD34C
uniprot id: A0A2I2ZI35
names: Similarity
messages: Belongs to the ANKRD34 family.

9595:CNKSR1
gene id: 9595:CNKSR1
uniprot id: G3SD79
names: Similarity
messages: Belongs to the CNKSR family.

9595:GPR107
gene id: 9595:GPR107
uniprot id: A0A2I2ZIG7
uniprot id: A0A2I2ZY99
names: Subcellular Location Annotation
messages: Membrane

9595:BLOC1S6
gene id: 9595:BLOC1S6
uniprot id: A0A2I2ZIJ0
uniprot id: G3RDE4
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9595:NAALADL1
gene id: 9595:NAALADL1
uniprot id: A0A2I2YMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9595:PAIP2
gene id: 9595:PAIP2
uniprot id: G3S5H7
names: Similarity
messages: Belongs to the PAIP2 family.

9595:PATZ1
gene id: 9595:PATZ1
uniprot id: A0A2I2Y7W2
uniprot id: A0A2I2ZTQ2
uniprot id: G3RLU7
names: Subcellular Location Annotation
messages: Nucleus

9595:STOM
gene id: 9595:STOM
uniprot id: A0A2I2ZIH3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:ABAT
gene id: 9595:ABAT
uniprot id: G3R3N6
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9595:CA8
gene id: 9595:CA8
uniprot id: G3RXT0
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9595:KXD1
gene id: 9595:KXD1
uniprot id: A0A2I2Y232
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9595:PKP2
gene id: 9595:PKP2
uniprot id: A0A2I2YE74
uniprot id: G3RQ65
names: Similarity
messages: Belongs to the beta-catenin family.

9595:LDLRAD2
gene id: 9595:LDLRAD2
uniprot id: G3RBM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MAP7D2
gene id: 9595:MAP7D2
uniprot id: A0A2I2YYQ9
uniprot id: A0A2I2ZCB7
uniprot id: G3QXP4
names: Similarity
messages: Belongs to the MAP7 family.

9595:CAST
gene id: 9595:CAST
uniprot id: A0A2I2YI04
uniprot id: A0A2I2YK81
uniprot id: A0A2I2YMS0
uniprot id: A0A2I2YUD0
uniprot id: A0A2I2Z302
uniprot id: G3R1K6
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9595:SKAP2
gene id: 9595:SKAP2
uniprot id: A0A2I2Z1F9
uniprot id: G3QIB0
names: Similarity
messages: Belongs to the SKAP family.

9595:PRKAG1
gene id: 9595:PRKAG1
uniprot id: G3RW69
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9595:SPTBN2
gene id: 9595:SPTBN2
uniprot id: G3R7Q6
names: Similarity
messages: Belongs to the spectrin family.

9595:SERBP1
gene id: 9595:SERBP1
uniprot id: G3R4E0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:CRYZ
gene id: 9595:CRYZ
uniprot id: A0A2I2Y795
uniprot id: A0A2I2YE25
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9595:IRF1
gene id: 9595:IRF1
uniprot id: G3RDI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:FAM219B
gene id: 9595:FAM219B
uniprot id: G3RFM9
names: Similarity
messages: Belongs to the FAM219 family.

9595:NQO1
gene id: 9595:NQO1
uniprot id: A0A2I2ZYE4
uniprot id: G3QL89
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9595:PIWIL3
gene id: 9595:PIWIL3
uniprot id: A0A2I2YMB4
uniprot id: G3RHJ8
names: Similarity
messages: Belongs to the argonaute family.

9595:PRDX6
gene id: 9595:PRDX6
uniprot id: G3S6S1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9595:DESI1
gene id: 9595:DESI1
uniprot id: A0A2I2Z916
names: Similarity
messages: Belongs to the DeSI family.

9595:SPESP1
gene id: 9595:SPESP1
uniprot id: G3RCT2
names: Function
names: Similarity
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.

9595:PHC3
gene id: 9595:PHC3
uniprot id: G3QHX1
names: Subcellular Location Annotation
messages: Nucleus

9595:LHPP
gene id: 9595:LHPP
uniprot id: A0A2I2YBY1
uniprot id: A0A2I2Z6I8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9595:LOC101153957
gene id: 9595:LOC101153957
uniprot id: G3RDY2
names: Subcellular Location Annotation
messages: Nucleus

9595:CLTRN
gene id: 9595:CLTRN
uniprot id: G3SF03
names: Subcellular Location Annotation
messages: Membrane

9595:DSG1
gene id: 9595:DSG1
uniprot id: G3QD33
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9595:ST6GAL1
gene id: 9595:ST6GAL1
uniprot id: G3QUR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:RAD51
gene id: 9595:RAD51
uniprot id: A0A2I2YW66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9595:KCNJ6
gene id: 9595:KCNJ6
uniprot id: A0A2I2YHE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9595:CNRIP1
gene id: 9595:CNRIP1
uniprot id: A0A2I2ZFD8
uniprot id: G3RQU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9595:ODF1
gene id: 9595:ODF1
uniprot id: G3S8C1
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9595:CAPN1
gene id: 9595:CAPN1
uniprot id: G3QXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:EVX2
gene id: 9595:EVX2
uniprot id: G3S455
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC30A7
gene id: 9595:SLC30A7
uniprot id: A0A2I2ZEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9595:CER1
gene id: 9595:CER1
uniprot id: G3QGR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SKAP1
gene id: 9595:SKAP1
uniprot id: G3RA58
names: Similarity
messages: Belongs to the SKAP family.

9595:OSBPL8
gene id: 9595:OSBPL8
uniprot id: G3S7W9
names: Similarity
messages: Belongs to the OSBP family.

9595:MOCS2
gene id: 9595:MOCS2
uniprot id: G3QG23
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9595:EIF2B5
gene id: 9595:EIF2B5
uniprot id: G3QWV1
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9595:FRK
gene id: 9595:FRK
uniprot id: G3SKL2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:CDC37L1
gene id: 9595:CDC37L1
uniprot id: G3QVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9595:PPA2
gene id: 9595:PPA2
uniprot id: A0A2I2ZNJ3
uniprot id: G3RSM6
names: Similarity
messages: Belongs to the PPase family.

9595:ZMPSTE24
gene id: 9595:ZMPSTE24
uniprot id: G3SDX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9595:LOC101132458
gene id: 9595:LOC101132458
uniprot id: G3RZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9595:LOC101133344
gene id: 9595:LOC101133344
uniprot id: G3RQE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TNS2
gene id: 9595:TNS2
uniprot id: A0A2I2YM20
uniprot id: G3RFX5
uniprot id: G3S3Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9595:MANEAL
gene id: 9595:MANEAL
uniprot id: A0A2I2YYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:RECQL
gene id: 9595:RECQL
uniprot id: A0A2I2ZF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9595:POLR1B
gene id: 9595:POLR1B
uniprot id: G3RCD9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9595:BDH1
gene id: 9595:BDH1
uniprot id: G3R6E1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:FPGS
gene id: 9595:FPGS
uniprot id: G3QF64
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9595:LOC101134598
gene id: 9595:LOC101134598
uniprot id: G3S8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MLLT11
gene id: 9595:MLLT11
uniprot id: A0A2I2Y341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9595:MMP1
gene id: 9595:MMP1
uniprot id: G3R0I7
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:FTSJ3
gene id: 9595:FTSJ3
uniprot id: G3QV89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9595:NUP93
gene id: 9595:NUP93
uniprot id: A0A2I2Z272
uniprot id: G3R3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9595:SLC1A5
gene id: 9595:SLC1A5
uniprot id: G3R0B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:IL13RA1
gene id: 9595:IL13RA1
uniprot id: G3RFC4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9595:FDFT1
gene id: 9595:FDFT1
uniprot id: A0A2I2YI48
uniprot id: G3QFR9
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9595:INSL6
gene id: 9595:INSL6
uniprot id: G3R094
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

9595:PKLR
gene id: 9595:PKLR
uniprot id: G3S6L6
names: Similarity
messages: Belongs to the pyruvate kinase family.

9595:ATL2
gene id: 9595:ATL2
uniprot id: A0A2I2Z6Z3
uniprot id: A0A2I2ZE35
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:SH3BGRL2
gene id: 9595:SH3BGRL2
uniprot id: G3RR85
names: Similarity
messages: Belongs to the SH3BGR family.

9595:WWOX
gene id: 9595:WWOX
uniprot id: A0A2I2ZPP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9595:IAH1
gene id: 9595:IAH1
uniprot id: A0A2I2YXY6
uniprot id: G3QHB0
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9595:TAF11
gene id: 9595:TAF11
uniprot id: A0A2I2ZH01
uniprot id: G3R9I8
names: Similarity
messages: Belongs to the TAF11 family.

9595:HRH2
gene id: 9595:HRH2
uniprot id: A0A2I2Y6Q5
uniprot id: G3R543
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SFXN5
gene id: 9595:SFXN5
uniprot id: G3QRA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9595:NEUROD4
gene id: 9595:NEUROD4
uniprot id: G3QNT6
names: Subcellular Location Annotation
messages: Nucleus

9595:TM4SF18
gene id: 9595:TM4SF18
uniprot id: G3QIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:FUS
gene id: 9595:FUS
uniprot id: G3RPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9595:ENTPD3
gene id: 9595:ENTPD3
uniprot id: G3QQQ1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:ACTA2
gene id: 9595:ACTA2
uniprot id: G3RC70
names: Similarity
messages: Belongs to the actin family.

9595:ORMDL1
gene id: 9595:ORMDL1
uniprot id: G3RGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9595:EFS
gene id: 9595:EFS
uniprot id: G3RLP9
names: Similarity
messages: Belongs to the CAS family.

9595:SLC5A12
gene id: 9595:SLC5A12
uniprot id: G3R1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9595:DEFB113
gene id: 9595:DEFB113
uniprot id: G3SAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:VPS72
gene id: 9595:VPS72
uniprot id: A0A2I2ZUZ9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9595:LOC101133285
gene id: 9595:LOC101133285
uniprot id: G3RR03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:DOP1A
gene id: 9595:DOP1A
uniprot id: G3QDW5
uniprot id: G3S5F3
names: Similarity
messages: Belongs to the dopey family.

9595:PABPC3
gene id: 9595:PABPC3
uniprot id: A0A2I2ZA10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9595:PEX16
gene id: 9595:PEX16
uniprot id: G3QIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9595:LAMTOR5
gene id: 9595:LAMTOR5
uniprot id: G3RK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9595:C18H18orf21
gene id: 9595:C18H18orf21
uniprot id: A0A2I2YMY3
names: Similarity
messages: Belongs to the UPF0711 family.

9595:CCDC90B
gene id: 9595:CCDC90B
uniprot id: A0A2I2Y288
names: Similarity
messages: Belongs to the CCDC90 family.

9595:METTL3
gene id: 9595:METTL3
uniprot id: G3QT25
names: Similarity
messages: Belongs to the MT-A70-like family.

9595:WLS
gene id: 9595:WLS
uniprot id: G3S8B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9595:LOC101132777
gene id: 9595:LOC101132777
uniprot id: G3RIZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9595:SMIM5
gene id: 9595:SMIM5
uniprot id: G3R235
names: Subcellular Location Annotation
messages: Membrane

9595:ZNF274
gene id: 9595:ZNF274
uniprot id: G3RTC3
names: Subcellular Location Annotation
messages: Nucleus

9595:LIPH
gene id: 9595:LIPH
uniprot id: G3S122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9595:SLC4A10
gene id: 9595:SLC4A10
uniprot id: A0A2I2ZDH3
uniprot id: G3S614
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:FYTTD1
gene id: 9595:FYTTD1
uniprot id: G3R7N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9595:GRK4
gene id: 9595:GRK4
uniprot id: A0A2I2ZNV3
uniprot id: G3R6J0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9595:ENO3
gene id: 9595:ENO3
uniprot id: A0A2I2Y9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9595:RPL15
gene id: 9595:RPL15
uniprot id: A0A2I2Z4M0
uniprot id: G3SD81
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9595:SV2B
gene id: 9595:SV2B
uniprot id: G3RFJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9595:RPL6
gene id: 9595:RPL6
uniprot id: G3QLG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9595:ELF5
gene id: 9595:ELF5
uniprot id: A0A2I2YK01
uniprot id: G3QVG3
uniprot id: G3RZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:PPY
gene id: 9595:PPY
uniprot id: G3RAQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9595:RXRG
gene id: 9595:RXRG
uniprot id: A0A2I2YQE2
uniprot id: G3S7Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9595:NDUFAF1
gene id: 9595:NDUFAF1
uniprot id: A0A2I2ZYF3
uniprot id: Q0MQ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with ECSIT. Interacts with ACAD9. At early stages of complex I assembly, it is found in intermediate subcomplexes that contain different subunits including NDUFB6, NDUFA6, NDUFA9, NDUFS3, NDUFS7, ND1, ND2 and ND3. Interacts with TMEM70 and TMEM242 (By similarity).

9595:TSSK6
gene id: 9595:TSSK6
uniprot id: A0A2I2YMX2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ZSCAN23
gene id: 9595:ZSCAN23
uniprot id: G3RNB1
names: Subcellular Location Annotation
messages: Nucleus

9595:PCK1
gene id: 9595:PCK1
uniprot id: G3R5Y2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9595:CAMK2D
gene id: 9595:CAMK2D
uniprot id: A0A2I2YPU1
uniprot id: A0A2I2ZH17
uniprot id: A0A2I2ZQH9
uniprot id: G3RYX1
uniprot id: G3S8D3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9595:NAT1
gene id: 9595:NAT1
uniprot id: A0A4P8J1E5
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9595:DDB1
gene id: 9595:DDB1
uniprot id: G3QN74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9595:GSDMB
gene id: 9595:GSDMB
uniprot id: A0A2I2YG62
uniprot id: G3QZ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9595:ARL2BP
gene id: 9595:ARL2BP
uniprot id: G3QRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9595:NSUN2
gene id: 9595:NSUN2
uniprot id: A0A2I2YDN2
uniprot id: A0A2I2Z719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9595:DEFA4
gene id: 9595:DEFA4
uniprot id: G3R5N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9595:RPL23A
gene id: 9595:RPL23A
uniprot id: G3SDX8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9595:COPE
gene id: 9595:COPE
uniprot id: G3QVQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9595:XYLT2
gene id: 9595:XYLT2
uniprot id: G3RN97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9595:HJV
gene id: 9595:HJV
uniprot id: G3QQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9595:STEAP4
gene id: 9595:STEAP4
uniprot id: G3RBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9595:NR1I3
gene id: 9595:NR1I3
uniprot id: A0A2I2YTE3
uniprot id: G3QSG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:BECN2
gene id: 9595:BECN2
uniprot id: G3QYP8
names: Similarity
messages: Belongs to the beclin family.

9595:RPS19BP1
gene id: 9595:RPS19BP1
uniprot id: G3R3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9595:LOC101132832
gene id: 9595:LOC101132832
uniprot id: A0A2I2YCH5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:HS3ST2
gene id: 9595:HS3ST2
uniprot id: G3RFC1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:MAPRE3
gene id: 9595:MAPRE3
uniprot id: A0A2I2Z4P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9595:KAT2B
gene id: 9595:KAT2B
uniprot id: G3RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9595:DLST
gene id: 9595:DLST
uniprot id: G3R7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9595:CCL14
gene id: 9595:CCL14
uniprot id: G3SA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:SLC11A2
gene id: 9595:SLC11A2
uniprot id: A0A2I2ZA56
names: Similarity
messages: Belongs to the NRAMP family.

9595:EPHB4
gene id: 9595:EPHB4
uniprot id: G3RGW7
names: Subcellular Location Annotation
messages: Membrane

9595:CALCB
gene id: 9595:CALCB
uniprot id: A0A2I2ZIT6
names: Similarity
messages: Belongs to the calcitonin family.

9595:DUSP27
gene id: 9595:DUSP27
uniprot id: G3QPE2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:LOC101140204
gene id: 9595:LOC101140204
uniprot id: A0A2I2YNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:TRPM1
gene id: 9595:TRPM1
uniprot id: A0A2I2YEW3
uniprot id: A0A2I2ZQW0
names: Subcellular Location Annotation
messages: Membrane

9595:TMPRSS2
gene id: 9595:TMPRSS2
uniprot id: G3SFM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GNRHR
gene id: 9595:GNRHR
uniprot id: G3RJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101148899
gene id: 9595:LOC101148899
uniprot id: G3QSU3
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9595:LOC101131791
gene id: 9595:LOC101131791
uniprot id: G3RL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:RAD23A
gene id: 9595:RAD23A
uniprot id: G3SC93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9595:FAIM2
gene id: 9595:FAIM2
uniprot id: G3SA66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9595:CNOT8
gene id: 9595:CNOT8
uniprot id: A0A2I2YK27
uniprot id: G3R4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9595:MTMR2
gene id: 9595:MTMR2
uniprot id: G3RYF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9595:LGI1
gene id: 9595:LGI1
uniprot id: G3QIJ9
names: Subcellular Location Annotation
messages: Secreted

9595:QPCT
gene id: 9595:QPCT
uniprot id: G3QZV3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9595:DEFB116
gene id: 9595:DEFB116
uniprot id: G3QTR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:CPA6
gene id: 9595:CPA6
uniprot id: G3QSV0
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:KCNJ14
gene id: 9595:KCNJ14
uniprot id: G3RC96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:APOC3
gene id: 9595:APOC3
uniprot id: G3QY94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9595:GBP5
gene id: 9595:GBP5
uniprot id: G3QH22
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:ATPSCKMT
gene id: 9595:ATPSCKMT
uniprot id: G3RDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9595:KCNMB4
gene id: 9595:KCNMB4
uniprot id: G3RAE5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9595:FSHB
gene id: 9595:FSHB
uniprot id: A0A2K5TIY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9595:GPC5
gene id: 9595:GPC5
uniprot id: G3RGF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9595:TYROBP
gene id: 9595:TYROBP
uniprot id: G3RH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9595:CCL15
gene id: 9595:CCL15
uniprot id: G3QJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:MFAP1
gene id: 9595:MFAP1
uniprot id: A0A2I2YJD5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9595:ACTL8
gene id: 9595:ACTL8
uniprot id: G3RFH6
names: Similarity
messages: Belongs to the actin family.

9595:H1-5
gene id: 9595:H1-5
uniprot id: G3QGG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:FABP9
gene id: 9595:FABP9
uniprot id: A0A2I2ZN75
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:FAM118B
gene id: 9595:FAM118B
uniprot id: G3RK42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9595:PSD
gene id: 9595:PSD
uniprot id: G3QVQ5
names: Subcellular Location Annotation
messages: ruffle membrane

9595:THAP1
gene id: 9595:THAP1
uniprot id: G3SK76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9595:NFIB
gene id: 9595:NFIB
uniprot id: A0A2I2ZKD3
uniprot id: G3S9D9
uniprot id: G3SIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9595:ABI3
gene id: 9595:ABI3
uniprot id: G3QHT8
names: Similarity
messages: Belongs to the ABI family.

9595:IRX3
gene id: 9595:IRX3
uniprot id: G3RDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9595:PHF5A
gene id: 9595:PHF5A
uniprot id: G3QFL1
names: Similarity
messages: Belongs to the PHF5 family.

9595:UNC5CL
gene id: 9595:UNC5CL
uniprot id: G3R8R2
names: Similarity
messages: Belongs to the unc-5 family.

9595:PFKFB2
gene id: 9595:PFKFB2
uniprot id: A0A2I2Y745
uniprot id: A0A2I2ZII5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9595:GSDME
gene id: 9595:GSDME
uniprot id: G3QR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9595:TMEM39A
gene id: 9595:TMEM39A
uniprot id: G3R863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9595:PPP1R3C
gene id: 9595:PPP1R3C
uniprot id: A0A2I2YWD3
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9595:CDC14A
gene id: 9595:CDC14A
uniprot id: A0A2I2YAS9
uniprot id: A0A2I2Z2L9
uniprot id: A0A2I2Z754
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9595:TGM1
gene id: 9595:TGM1
uniprot id: G3RJ54
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:LOC101140761
gene id: 9595:LOC101140761
uniprot id: G3SFL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:RRP15
gene id: 9595:RRP15
uniprot id: G3RKD0
names: Similarity
messages: Belongs to the RRP15 family.

9595:IFNK
gene id: 9595:IFNK
uniprot id: G3S4T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9595:SLC25A31
gene id: 9595:SLC25A31
uniprot id: G3RDN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9595:HSBP1L1
gene id: 9595:HSBP1L1
uniprot id: G3RZB0
names: Similarity
messages: Belongs to the HSBP1 family.

9595:GRIN3A
gene id: 9595:GRIN3A
uniprot id: G3R217
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:DMGDH
gene id: 9595:DMGDH
uniprot id: G3QL10
names: Similarity
messages: Belongs to the GcvT family.

9595:LDHAL6B
gene id: 9595:LDHAL6B
uniprot id: G3S7D5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:INKA2
gene id: 9595:INKA2
uniprot id: G3SJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9595:ARSD
gene id: 9595:ARSD
uniprot id: G3SAU8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:CRP
gene id: 9595:CRP
uniprot id: G3S3N2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SUV39H1
gene id: 9595:SUV39H1
uniprot id: G3S7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9595:SEC24C
gene id: 9595:SEC24C
uniprot id: G3QTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:NDUFB11
gene id: 9595:NDUFB11
uniprot id: Q0MQJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with BCAP31.
messages: Mitochondrion inner membrane

9595:CD1B
gene id: 9595:CD1B
uniprot id: G3QRI4
names: Similarity
messages: Belongs to the MHC class I family.

9595:FANCM
gene id: 9595:FANCM
uniprot id: G3QZQ3
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9595:PHACTR1
gene id: 9595:PHACTR1
uniprot id: G3QML2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

9595:TRNT1
gene id: 9595:TRNT1
uniprot id: G3RGZ9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9595:SLC37A1
gene id: 9595:SLC37A1
uniprot id: G3R8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9595:USP26
gene id: 9595:USP26
uniprot id: G3SHA9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:ACAD8
gene id: 9595:ACAD8
uniprot id: G3QVA8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:CD1C
gene id: 9595:CD1C
uniprot id: G3QE10
names: Similarity
messages: Belongs to the MHC class I family.

9595:ITGB2
gene id: 9595:ITGB2
uniprot id: G3REV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9595:NF2
gene id: 9595:NF2
uniprot id: A0A2I2YM46
uniprot id: A0A2I2YZG5
uniprot id: A0A2I2ZFQ4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:ANK1
gene id: 9595:ANK1
uniprot id: A0A2I2YQD4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:AP3B2
gene id: 9595:AP3B2
uniprot id: G3QV79
uniprot id: G3SEA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9595:LOC101148112
gene id: 9595:LOC101148112
uniprot id: G3R719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LRRC8E
gene id: 9595:LRRC8E
uniprot id: G3S403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:LOC101140970
gene id: 9595:LOC101140970
uniprot id: G3QIY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NMUR1
gene id: 9595:NMUR1
uniprot id: G3RJE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9595:ZC3H15
gene id: 9595:ZC3H15
uniprot id: G3QCX0
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9595:PRICKLE2
gene id: 9595:PRICKLE2
uniprot id: G3QVK9
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9595:FOXA2
gene id: 9595:FOXA2
uniprot id: G3RYD0
names: Subcellular Location Annotation
messages: Nucleus

9595:C3
gene id: 9595:C3
uniprot id: G3SA61
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9595:TMEM35B
gene id: 9595:TMEM35B
uniprot id: G3S3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9595:PSMC5
gene id: 9595:PSMC5
uniprot id: G3QV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9595:TMEM258
gene id: 9595:TMEM258
uniprot id: G3R9Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9595:KCNN3
gene id: 9595:KCNN3
uniprot id: A0A2I2ZL41
uniprot id: G3S7U0
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101131103
gene id: 9595:LOC101131103
uniprot id: A0A2I2ZDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TIMM10
gene id: 9595:TIMM10
uniprot id: G3R9P2
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9595:POU4F2
gene id: 9595:POU4F2
uniprot id: G3QHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:SGK2
gene id: 9595:SGK2
uniprot id: G3SEL5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:COPS8
gene id: 9595:COPS8
uniprot id: A0A2I2ZLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9595:NDUFAB1
gene id: 9595:NDUFAB1
uniprot id: Q0MQC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
messages: Mammalian complex I is composed of 45 different subunits. Interacts with ETFRF1. Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. The complex interacts with the mitochondrial large ribosomal subunit. Interacts with alpha-1-microglobulin chain; this interaction is required for the maintenance of mitochondrial redox homeostasis. Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine desulfurase activity of NFS1.
messages: Mitochondrion

9595:UHRF1
gene id: 9595:UHRF1
uniprot id: G3RVG5
names: Subcellular Location Annotation
messages: Nucleus

9595:SEMA3A
gene id: 9595:SEMA3A
uniprot id: G3RGH7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RPL38
gene id: 9595:RPL38
uniprot id: G3QET2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9595:LAD1
gene id: 9595:LAD1
uniprot id: G3RAB3
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

9595:MIGA2
gene id: 9595:MIGA2
uniprot id: G3RUJ6
names: Similarity
messages: Belongs to the mitoguardin family.

9595:ADH5
gene id: 9595:ADH5
uniprot id: G3RV06
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9595:HAPLN3
gene id: 9595:HAPLN3
uniprot id: G3QRC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RPL24
gene id: 9595:RPL24
uniprot id: G3R7I4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9595:CEP57L1
gene id: 9595:CEP57L1
uniprot id: G3RG76
names: Similarity
messages: Belongs to the translokin family.

9595:SHROOM2
gene id: 9595:SHROOM2
uniprot id: A0A2I2Y6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9595:GJB4
gene id: 9595:GJB4
uniprot id: G3R0R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:PYROXD1
gene id: 9595:PYROXD1
uniprot id: A0A2I2Z7N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9595:LOC101138925
gene id: 9595:LOC101138925
uniprot id: G3QZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DNER
gene id: 9595:DNER
uniprot id: G3RFZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101149550
gene id: 9595:LOC101149550
uniprot id: G3QX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DSC2
gene id: 9595:DSC2
uniprot id: G3QTI1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9595:LYPD2
gene id: 9595:LYPD2
uniprot id: G3RTI8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:GFRA1
gene id: 9595:GFRA1
uniprot id: G3QZP5
uniprot id: G3RQT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9595:ARMT1
gene id: 9595:ARMT1
uniprot id: G3S2Y4
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9595:TRPC3
gene id: 9595:TRPC3
uniprot id: G3QPH6
names: Subcellular Location Annotation
messages: Membrane

9595:PIP
gene id: 9595:PIP
uniprot id: A0A885
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1 (By similarity).
messages: Secreted

9595:CRYGB
gene id: 9595:CRYGB
uniprot id: G3R0K8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:FOXR1
gene id: 9595:FOXR1
uniprot id: G3QFT0
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC33A1
gene id: 9595:SLC33A1
uniprot id: G3RB72
names: Subcellular Location Annotation
messages: Membrane

9595:RUVBL2
gene id: 9595:RUVBL2
uniprot id: G3R1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9595:SAA4
gene id: 9595:SAA4
uniprot id: G3RZ43
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9595:DPPA5
gene id: 9595:DPPA5
uniprot id: G3R8J3
names: Similarity
messages: Belongs to the KHDC1 family.

9595:MRPS33
gene id: 9595:MRPS33
uniprot id: G3R292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9595:CACNB2
gene id: 9595:CACNB2
uniprot id: G3SGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9595:BTAF1
gene id: 9595:BTAF1
uniprot id: G3S6X7
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM20B
gene id: 9595:FAM20B
uniprot id: G3QJ63
names: Similarity
messages: Belongs to the FAM20 family.

9595:LOC101143890
gene id: 9595:LOC101143890
uniprot id: G3QYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GPR37L1
gene id: 9595:GPR37L1
uniprot id: G3RQ21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:EPHA3
gene id: 9595:EPHA3
uniprot id: G3RG43
names: Subcellular Location Annotation
messages: Membrane

9595:GJB1
gene id: 9595:GJB1
uniprot id: G3R5C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:PHF19
gene id: 9595:PHF19
uniprot id: G3QIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9595:IL10
gene id: 9595:IL10
uniprot id: G3REF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:STX19
gene id: 9595:STX19
uniprot id: G3R0G3
names: Similarity
messages: Belongs to the syntaxin family.

9595:SLC39A14
gene id: 9595:SLC39A14
uniprot id: A0A2I2YLD7
uniprot id: G3QMF7
names: Subcellular Location Annotation
messages: Membrane

9595:SYNDIG1
gene id: 9595:SYNDIG1
uniprot id: G3QEB6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:INTS7
gene id: 9595:INTS7
uniprot id: A0A2I2YZU0
uniprot id: G3R8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9595:LPCAT4
gene id: 9595:LPCAT4
uniprot id: G3QXF8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:RPL34
gene id: 9595:RPL34
uniprot id: G3QXE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9595:KCNH5
gene id: 9595:KCNH5
uniprot id: A0A2I2ZYC8
uniprot id: G3SKT9
names: Subcellular Location Annotation
messages: Membrane

9595:ZBTB25
gene id: 9595:ZBTB25
uniprot id: A1YEX3
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:CBFB
gene id: 9595:CBFB
uniprot id: A0A2I2ZPC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9595:ELOVL5
gene id: 9595:ELOVL5
uniprot id: G3R6X9
uniprot id: G3S6X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9595:FMO2
gene id: 9595:FMO2
uniprot id: G3R0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9595:PFKL
gene id: 9595:PFKL
uniprot id: G3RVJ3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SORCS2
gene id: 9595:SORCS2
uniprot id: G3RID4
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9595:C1QBP
gene id: 9595:C1QBP
uniprot id: G3QJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9595:MTMR4
gene id: 9595:MTMR4
uniprot id: G3RD67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9595:LOC101137471
gene id: 9595:LOC101137471
uniprot id: G3S0Z6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:GPR20
gene id: 9595:GPR20
uniprot id: G3R4Y1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:MAPK13
gene id: 9595:MAPK13
uniprot id: G3QMX6
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9595:ZC3HAV1
gene id: 9595:ZC3HAV1
uniprot id: G3QEF0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:FAM189A2
gene id: 9595:FAM189A2
uniprot id: G3R6J2
names: Similarity
messages: Belongs to the ENTREP family.

9595:UBE2F
gene id: 9595:UBE2F
uniprot id: G3R574
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:ST13
gene id: 9595:ST13
uniprot id: G3S180
names: Similarity
messages: Belongs to the FAM10 family.

9595:KCNH3
gene id: 9595:KCNH3
uniprot id: G3QGS8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9595:SLC9A8
gene id: 9595:SLC9A8
uniprot id: G3QHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9595:LOC101127189
gene id: 9595:LOC101127189
uniprot id: G3QD36
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9595:FABP12
gene id: 9595:FABP12
uniprot id: G3RKZ2
uniprot id: G3SEZ9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:NUP35
gene id: 9595:NUP35
uniprot id: G3R368
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9595:FABP4
gene id: 9595:FABP4
uniprot id: G3QWM2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:JUND
gene id: 9595:JUND
uniprot id: G3S843
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9595:ANAPC10
gene id: 9595:ANAPC10
uniprot id: G3S5D3
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9595:SLC52A2
gene id: 9595:SLC52A2
uniprot id: G3SIW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9595:OGG1
gene id: 9595:OGG1
uniprot id: G3RZB6
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9595:MAK16
gene id: 9595:MAK16
uniprot id: G3R4M4
names: Similarity
messages: Belongs to the MAK16 family.

9595:ANXA9
gene id: 9595:ANXA9
uniprot id: G3QS41
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:LCE3B
gene id: 9595:LCE3B
uniprot id: G3QIF5
names: Similarity
messages: Belongs to the LCE family.

9595:LOC101148107
gene id: 9595:LOC101148107
uniprot id: A0A2I2ZK90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Membrane
messages: Nucleus outer membrane

9595:BBS5
gene id: 9595:BBS5
uniprot id: A0A2I2ZW94
uniprot id: G3QRG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9595:TNFAIP6
gene id: 9595:TNFAIP6
uniprot id: G3S056
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:APEX1
gene id: 9595:APEX1
uniprot id: G3QI91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9595:PTPRG
gene id: 9595:PTPRG
uniprot id: G3QVF1
uniprot id: G3SI67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9595:ABITRAM
gene id: 9595:ABITRAM
uniprot id: G3QNM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9595:FASLG
gene id: 9595:FASLG
uniprot id: G3S9V6
uniprot id: G3SGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9595:SLC7A14
gene id: 9595:SLC7A14
uniprot id: A0A2I2Y2E8
names: Subcellular Location Annotation
messages: Membrane

9595:SLC6A11
gene id: 9595:SLC6A11
uniprot id: A0A2I2YL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:LOC101143962
gene id: 9595:LOC101143962
uniprot id: G3RXM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:BOD1
gene id: 9595:BOD1
uniprot id: G3R5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9595:SLC27A6
gene id: 9595:SLC27A6
uniprot id: G3RXT6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:CLSPN
gene id: 9595:CLSPN
uniprot id: G3QT52
names: Subcellular Location Annotation
messages: Nucleus

9595:PARP11
gene id: 9595:PARP11
uniprot id: A0A2I2YPT4
uniprot id: A0A2I2Z558
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:CDK9
gene id: 9595:CDK9
uniprot id: G3R636
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:MIP
gene id: 9595:MIP
uniprot id: G3RKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:TIMM8A
gene id: 9595:TIMM8A
uniprot id: G3S6N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9595:NKX2-3
gene id: 9595:NKX2-3
uniprot id: G3S329
names: Subcellular Location Annotation
messages: Nucleus

9595:IMMT
gene id: 9595:IMMT
uniprot id: A0A2I2Y8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9595:PPIL6
gene id: 9595:PPIL6
uniprot id: A0A2I2YLV2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:TSEN34
gene id: 9595:TSEN34
uniprot id: A0A2I2YDD3
uniprot id: G3QYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9595:PER2
gene id: 9595:PER2
uniprot id: G3QPG7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:CETP
gene id: 9595:CETP
uniprot id: G3QGV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.
messages: Secreted

9595:CSGALNACT1
gene id: 9595:CSGALNACT1
uniprot id: G3R2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9595:FUCA1
gene id: 9595:FUCA1
uniprot id: G3QV26
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9595:TOR3A
gene id: 9595:TOR3A
uniprot id: A0A2I2ZGQ9
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9595:SLC25A34
gene id: 9595:SLC25A34
uniprot id: G3RGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:TMEM43
gene id: 9595:TMEM43
uniprot id: G3RKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9595:LOC101153360
gene id: 9595:LOC101153360
uniprot id: G3SD53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:CHRM3
gene id: 9595:CHRM3
uniprot id: Q9N2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (By similarity). Interacts with TMEM147 (By similarity).
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity).

9595:PSD2
gene id: 9595:PSD2
uniprot id: G3S018
names: Subcellular Location Annotation
messages: ruffle membrane

9595:CTNS
gene id: 9595:CTNS
uniprot id: A0A2I2Y463
uniprot id: G3R346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9595:MSH5
gene id: 9595:MSH5
uniprot id: A0A2I2YSF4
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9595:HHIP
gene id: 9595:HHIP
uniprot id: G3RC18
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CASP2
gene id: 9595:CASP2
uniprot id: G3QLZ6
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:CEP76
gene id: 9595:CEP76
uniprot id: G3QZM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9595:CSTF1
gene id: 9595:CSTF1
uniprot id: G3QW97
names: Subcellular Location Annotation
messages: Nucleus

9595:NUBPL
gene id: 9595:NUBPL
uniprot id: G3R2S8
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9595:CFB
gene id: 9595:CFB
uniprot id: Q864V9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).
messages: Monomer (By similarity). Part of the C3-convertase enzyme complex comprised of Complement C3 beta chain (C3b) and Complement factor B Bb fragment (Bb) and CFP (By similarity). Interacts to C3b; this interaction is dependent on the presence of Mg2+ (By similarity). Interacts to CFP; this interaction contributes to the stabilization of the active C3-convertase enzyme complex (By similarity).
messages: Secreted
messages: The unliganded VWA domain has an inactive 'locked' conformation whereby the scissile Arg-259|Lys-260 bond is protected from proteolytic activation.

9595:GRAMD1A
gene id: 9595:GRAMD1A
uniprot id: G3RG58
uniprot id: G3RV31
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ITGA10
gene id: 9595:ITGA10
uniprot id: G3RHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:TMEM168
gene id: 9595:TMEM168
uniprot id: G3RLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9595:TRIM2
gene id: 9595:TRIM2
uniprot id: A0A2I2YQC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9595:LOC101144524
gene id: 9595:LOC101144524
uniprot id: G3QT78
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9595:KRT82
gene id: 9595:KRT82
uniprot id: G3QJZ6
names: Similarity
messages: Belongs to the intermediate filament family.

9595:LOC109024612
gene id: 9595:LOC109024612
uniprot id: A0A2I2Y4J7
names: Similarity
messages: Belongs to the MIF family.

9595:TGIF2LX
gene id: 9595:TGIF2LX
uniprot id: Q8MIE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: May have a transcription role in testis.
messages: Nucleus

9595:TFRC
gene id: 9595:TFRC
uniprot id: G3QWC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9595:ATL3
gene id: 9595:ATL3
uniprot id: A0A2I2ZNA4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:RFC4
gene id: 9595:RFC4
uniprot id: A0A2I2Y7Y2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9595:DGAT1
gene id: 9595:DGAT1
uniprot id: G3RU45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9595:ZDHHC13
gene id: 9595:ZDHHC13
uniprot id: G3QQ63
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:HAO2
gene id: 9595:HAO2
uniprot id: G3R1D9
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9595:KCNH1
gene id: 9595:KCNH1
uniprot id: G3SKG7
names: Subcellular Location Annotation
messages: Membrane

9595:MARCKSL1
gene id: 9595:MARCKSL1
uniprot id: G3R7W1
names: Similarity
messages: Belongs to the MARCKS family.

9595:PROKR1
gene id: 9595:PROKR1
uniprot id: G3RJH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:CYSLTR2
gene id: 9595:CYSLTR2
uniprot id: A0A2I2ZRR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:TUBG1
gene id: 9595:TUBG1
uniprot id: G3SAS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9595:CSNK2B
gene id: 9595:CSNK2B
uniprot id: A0A2I2Y5K6
uniprot id: G3QS09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9595:RSPO3
gene id: 9595:RSPO3
uniprot id: G3SBH2
names: Similarity
messages: Belongs to the R-spondin family.

9595:ZSCAN1
gene id: 9595:ZSCAN1
uniprot id: G3RHN2
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101124317
gene id: 9595:LOC101124317
uniprot id: G3RPV0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:EDA2R
gene id: 9595:EDA2R
uniprot id: G3R1A8
uniprot id: G3SBP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FAM221A
gene id: 9595:FAM221A
uniprot id: A0A2I2Y8K3
uniprot id: A0A2I2YCH6
uniprot id: G3QG28
names: Similarity
messages: Belongs to the FAM221 family.

9595:CASP5
gene id: 9595:CASP5
uniprot id: G3RI80
uniprot id: G3S719
uniprot id: G3SB10
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:HSD17B7
gene id: 9595:HSD17B7
uniprot id: G3R6M4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9595:LOC101152850
gene id: 9595:LOC101152850
uniprot id: G3S8W7
names: Similarity
messages: Belongs to the PRR23 family.

9595:NTN4
gene id: 9595:NTN4
uniprot id: A0A2I2Z326
uniprot id: G3RCW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HS3ST3A1
gene id: 9595:HS3ST3A1
uniprot id: G3RXI3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:PPM1L
gene id: 9595:PPM1L
uniprot id: A0A2I2YNX0
names: Similarity
messages: Belongs to the PP2C family.

9595:P2RX7
gene id: 9595:P2RX7
uniprot id: G3RD86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9595:TNC
gene id: 9595:TNC
uniprot id: G3R3R9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:CSE1L
gene id: 9595:CSE1L
uniprot id: G3SCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9595:JPH1
gene id: 9595:JPH1
uniprot id: G3QK17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9595:IPO13
gene id: 9595:IPO13
uniprot id: G3RJT7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9595:HADHB
gene id: 9595:HADHB
uniprot id: G3S6V7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:ETV2
gene id: 9595:ETV2
uniprot id: A0A2I2Y8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:MYF6
gene id: 9595:MYF6
uniprot id: G3QP01
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC9A1
gene id: 9595:SLC9A1
uniprot id: G3QGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane

9595:ERCC2
gene id: 9595:ERCC2
uniprot id: A0A2I2ZV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9595:TXLNG
gene id: 9595:TXLNG
uniprot id: G3QIX7
names: Similarity
messages: Belongs to the taxilin family.

9595:DHRS9
gene id: 9595:DHRS9
uniprot id: G3RCJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:MS4A8
gene id: 9595:MS4A8
uniprot id: G3QDB4
names: Similarity
messages: Belongs to the MS4A family.

9595:CTLA4
gene id: 9595:CTLA4
uniprot id: G3QY54
uniprot id: G3S368
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9595:PSME3IP1
gene id: 9595:PSME3IP1
uniprot id: G3QMW6
names: Subcellular Location Annotation
messages: Nucleus

9595:CAP1
gene id: 9595:CAP1
uniprot id: A0A2I2ZQK8
uniprot id: G3SA10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9595:ADGRD1
gene id: 9595:ADGRD1
uniprot id: A0A2I2YC34
uniprot id: A0A2I2YZY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:UGGT2
gene id: 9595:UGGT2
uniprot id: G3R5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9595:MRPL34
gene id: 9595:MRPL34
uniprot id: G3QSN3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9595:DTNA
gene id: 9595:DTNA
uniprot id: G3RMV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9595:METTL16
gene id: 9595:METTL16
uniprot id: G3R2P8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

9595:CAMP
gene id: 9595:CAMP
uniprot id: A0A2K5TIY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9595:DRP2
gene id: 9595:DRP2
uniprot id: G3QNS2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
messages: dendrite

9595:APOA2
gene id: 9595:APOA2
uniprot id: P0DJG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A2 family.
messages: Homodimer; disulfide-linked (PubMed:21298813). Interacts with NAXE and NDRG1 (By similarity).
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Plasma.
messages: Secreted

9595:BCL9L
gene id: 9595:BCL9L
uniprot id: G3QYM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9595:MPI
gene id: 9595:MPI
uniprot id: A0A2I2Z5A4
uniprot id: G3RFM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9595:CLN3
gene id: 9595:CLN3
uniprot id: A0A2I2Y7A6
uniprot id: A0A2I2YA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9595:AGTR2
gene id: 9595:AGTR2
uniprot id: A0A2I2ZVH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9595:WNT3
gene id: 9595:WNT3
uniprot id: G3RQ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:COX5A
gene id: 9595:COX5A
uniprot id: A0A2I2YSZ5
uniprot id: B0VYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:INPP4B
gene id: 9595:INPP4B
uniprot id: G3S6A4
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9595:HSPB8
gene id: 9595:HSPB8
uniprot id: G3RC33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9595:CBX8
gene id: 9595:CBX8
uniprot id: G3QPR3
names: Subcellular Location Annotation
messages: Nucleus

9595:ANKH
gene id: 9595:ANKH
uniprot id: A0A2I2ZWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9595:RTN1
gene id: 9595:RTN1
uniprot id: A0A2I2YQS8
uniprot id: A0A2I2ZXC9
uniprot id: G3QST3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101140217
gene id: 9595:LOC101140217
uniprot id: G3SDK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CCHCR1
gene id: 9595:CCHCR1
uniprot id: G3R6G3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9595:HPS3
gene id: 9595:HPS3
uniprot id: G3S9Z3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9595:LOC101137142
gene id: 9595:LOC101137142
uniprot id: G3QR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HADHA
gene id: 9595:HADHA
uniprot id: G3SJ02
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9595:OOEP
gene id: 9595:OOEP
uniprot id: G3RKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

9595:CAD
gene id: 9595:CAD
uniprot id: G3R7L6
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9595:GTF2H4
gene id: 9595:GTF2H4
uniprot id: G3REB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9595:C8H8orf33
gene id: 9595:C8H8orf33
uniprot id: G3RKS6
names: Similarity
messages: Belongs to the UPF0488 family.

9595:SIAH1
gene id: 9595:SIAH1
uniprot id: G3S6X6
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9595:SH3YL1
gene id: 9595:SH3YL1
uniprot id: A0A2I2ZRD2
uniprot id: G3QF02
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9595:RPGRIP1
gene id: 9595:RPGRIP1
uniprot id: G3RY05
names: Similarity
messages: Belongs to the RPGRIP1 family.

9595:CSF3R
gene id: 9595:CSF3R
uniprot id: G3S1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:IL1RAP
gene id: 9595:IL1RAP
uniprot id: G3R8P3
uniprot id: G3SCK7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:PQBP1
gene id: 9595:PQBP1
uniprot id: A1YFA7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic granule
messages: Except for the WW domain, the protein is intrinsically disordered.
messages: Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.
messages: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.
messages: Nucleus
messages: Nucleus speckle
messages: The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit.

9595:DMAP1
gene id: 9595:DMAP1
uniprot id: G3QLW4
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM214B
gene id: 9595:FAM214B
uniprot id: G3QL21
names: Similarity
messages: Belongs to the FAM214 family.

9595:GPRASP2
gene id: 9595:GPRASP2
uniprot id: G3RVY3
names: Similarity
messages: Belongs to the GPRASP family.

9595:CAMLG
gene id: 9595:CAMLG
uniprot id: G3R3Y6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9595:TJAP1
gene id: 9595:TJAP1
uniprot id: G3RGQ9
uniprot id: G3RYF0
names: Subcellular Location Annotation
messages: Membrane

9595:ATP5MC1
gene id: 9595:ATP5MC1
uniprot id: G3QGY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9595:FUCA2
gene id: 9595:FUCA2
uniprot id: G3R6L9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9595:CD36
gene id: 9595:CD36
uniprot id: G3QTG5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9595:ATP6V0D1
gene id: 9595:ATP6V0D1
uniprot id: G3RB21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:SYBU
gene id: 9595:SYBU
uniprot id: G3QM59
names: Subcellular Location Annotation
messages: Membrane

9595:ST8SIA1
gene id: 9595:ST8SIA1
uniprot id: G3QGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:POLA2
gene id: 9595:POLA2
uniprot id: G3QKN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9595:DHODH
gene id: 9595:DHODH
uniprot id: G3RB74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9595:CDK5
gene id: 9595:CDK5
uniprot id: G3RL35
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:PPP1R3B
gene id: 9595:PPP1R3B
uniprot id: A0A2I2YCH4
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9595:THBS2
gene id: 9595:THBS2
uniprot id: G3QK81
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CCBE1
gene id: 9595:CCBE1
uniprot id: G3RJV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FGB
gene id: 9595:FGB
uniprot id: G3RDU2
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9595:BRINP1
gene id: 9595:BRINP1
uniprot id: G3QR50
names: Similarity
messages: Belongs to the BRINP family.

9595:CHRDL1
gene id: 9595:CHRDL1
uniprot id: G3QJ73
names: Subcellular Location Annotation
messages: Secreted

9595:NDP
gene id: 9595:NDP
uniprot id: G3RCG7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:GADD45G
gene id: 9595:GADD45G
uniprot id: G3QQR8
names: Similarity
messages: Belongs to the GADD45 family.

9595:EDN3
gene id: 9595:EDN3
uniprot id: A0A2I2YNX1
uniprot id: G3RAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9595:LOC101152583
gene id: 9595:LOC101152583
uniprot id: A0A2I2YSB4
names: Similarity
messages: Belongs to the intermediate filament family.

9595:XKR5
gene id: 9595:XKR5
uniprot id: A0A2I2YUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9595:FBN1
gene id: 9595:FBN1
uniprot id: G3QLA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:ZEB2
gene id: 9595:ZEB2
uniprot id: A0A2I2Z563
uniprot id: A0A2I2ZGH3
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9595:GPRIN2
gene id: 9595:GPRIN2
uniprot id: G3RB88
names: Function
messages: May be involved in neurite outgrowth.

9595:LOC101133243
gene id: 9595:LOC101133243
uniprot id: A0A2I2ZAB6
uniprot id: G3RN58
uniprot id: G3SIB7
names: Subcellular Location Annotation
messages: cilium

9595:HIGD1C
gene id: 9595:HIGD1C
uniprot id: G3R9D1
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9595:TMEM14A
gene id: 9595:TMEM14A
uniprot id: G3QER3
names: Similarity
messages: Belongs to the TMEM14 family.

9595:CBX3
gene id: 9595:CBX3
uniprot id: G3RV49
names: Subcellular Location Annotation
messages: Nucleus

9595:UBE2D1
gene id: 9595:UBE2D1
uniprot id: A0A2I2YMV6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:S100A11
gene id: 9595:S100A11
uniprot id: G3R007
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9595:RSPH3
gene id: 9595:RSPH3
uniprot id: G3QMQ1
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

9595:S100G
gene id: 9595:S100G
uniprot id: A0A2I2ZVR9
names: Similarity
messages: Belongs to the S-100 family.

9595:AMIGO1
gene id: 9595:AMIGO1
uniprot id: G3S862
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9595:FERMT2
gene id: 9595:FERMT2
uniprot id: A0A2I2Y2T0
uniprot id: A0A2I2YNQ6
names: Similarity
messages: Belongs to the kindlin family.

9595:ADGRL2
gene id: 9595:ADGRL2
uniprot id: A0A2I2Z070
uniprot id: A0A2I2ZX12
names: Subcellular Location Annotation
messages: Membrane

9595:PNLIP
gene id: 9595:PNLIP
uniprot id: G3RIW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9595:SLC44A2
gene id: 9595:SLC44A2
uniprot id: A0A2I2YQW2
uniprot id: G3SEU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9595:PIAS3
gene id: 9595:PIAS3
uniprot id: A0A2I2YFU1
uniprot id: G3QWF6
names: Similarity
messages: Belongs to the PIAS family.

9595:PAQR5
gene id: 9595:PAQR5
uniprot id: G3QMZ6
uniprot id: G3S7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:GPR108
gene id: 9595:GPR108
uniprot id: G3RBK1
names: Subcellular Location Annotation
messages: Membrane

9595:CRELD1
gene id: 9595:CRELD1
uniprot id: G3RNI8
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MAMDC4
gene id: 9595:MAMDC4
uniprot id: A0A2I2YBF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CHD8
gene id: 9595:CHD8
uniprot id: A0A2I2YBF5
uniprot id: A0A2I2ZB14
uniprot id: A0A2I2ZYX2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9595:NR0B2
gene id: 9595:NR0B2
uniprot id: G3RH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:NDRG2
gene id: 9595:NDRG2
uniprot id: A0A2I2ZPJ6
uniprot id: G3QR61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

9595:SEMA4C
gene id: 9595:SEMA4C
uniprot id: G3RF86
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101142986
gene id: 9595:LOC101142986
uniprot id: G3RN90
names: Subcellular Location Annotation
messages: Membrane

9595:C11H11orf87
gene id: 9595:C11H11orf87
uniprot id: A0A2I2Y2H1
names: Subcellular Location Annotation
messages: Membrane

9595:SCML2
gene id: 9595:SCML2
uniprot id: G3RIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9595:NID1
gene id: 9595:NID1
uniprot id: G3SAI9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:ZFP36L1
gene id: 9595:ZFP36L1
uniprot id: A0A2I2ZGR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9595:LOC101135431
gene id: 9595:LOC101135431
uniprot id: Q6WUX8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space
messages: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

9595:SPRR2E
gene id: 9595:SPRR2E
uniprot id: A0A2I2ZQQ5
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:CDC6
gene id: 9595:CDC6
uniprot id: G3RHJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9595:KCNK6
gene id: 9595:KCNK6
uniprot id: G3R3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:BANF1
gene id: 9595:BANF1
uniprot id: G3S5Z8
names: Subcellular Location Annotation
messages: Nucleus

9595:DTNBP1
gene id: 9595:DTNBP1
uniprot id: A0A2I2YMU0
names: Similarity
messages: Belongs to the dysbindin family.

9595:RPP30
gene id: 9595:RPP30
uniprot id: G3RXX6
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9595:CAVIN4
gene id: 9595:CAVIN4
uniprot id: G3R2G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9595:IMMP1L
gene id: 9595:IMMP1L
uniprot id: G3RG04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9595:LOC101143702
gene id: 9595:LOC101143702
uniprot id: G3RZ81
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9595:MON1A
gene id: 9595:MON1A
uniprot id: A0A2I2YX97
uniprot id: G3R9A5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9595:MRPL9
gene id: 9595:MRPL9
uniprot id: G3QHN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9595:MRPS24
gene id: 9595:MRPS24
uniprot id: G3QSD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9595:CKAP2
gene id: 9595:CKAP2
uniprot id: G3QT12
names: Similarity
messages: Belongs to the CKAP2 family.

9595:UBA5
gene id: 9595:UBA5
uniprot id: G3QTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9595:MRPS14
gene id: 9595:MRPS14
uniprot id: G3QT30
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9595:CACTIN
gene id: 9595:CACTIN
uniprot id: G3R9X4
names: Similarity
messages: Belongs to the CACTIN family.

9595:PMVK
gene id: 9595:PMVK
uniprot id: G3RAP6
names: Subcellular Location Annotation
messages: cytosol

9595:CUL3
gene id: 9595:CUL3
uniprot id: A0A2I2ZJ89
names: Similarity
messages: Belongs to the cullin family.

9595:FAM227B
gene id: 9595:FAM227B
uniprot id: A0A2I2Y5Z0
names: Similarity
messages: Belongs to the FAM227 family.

9595:LARS2
gene id: 9595:LARS2
uniprot id: G3RI94
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:HRK
gene id: 9595:HRK
uniprot id: G3QTJ6
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Promotes apoptosis.

9595:HOMEZ
gene id: 9595:HOMEZ
uniprot id: G3QIF1
names: Subcellular Location Annotation
messages: Nucleus

9595:AMPD2
gene id: 9595:AMPD2
uniprot id: A0A2I2YTI3
uniprot id: G3RBY5
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9595:KDM4B
gene id: 9595:KDM4B
uniprot id: G3R2U2
uniprot id: G3RR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9595:PDHA1
gene id: 9595:PDHA1
uniprot id: A0A2I2Y5G2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9595:LOC101141302
gene id: 9595:LOC101141302
uniprot id: A0A2I2Z1F0
uniprot id: G3RKD8
names: Similarity
messages: Belongs to the Luc7 family.

9595:CLNS1A
gene id: 9595:CLNS1A
uniprot id: A0A2I2Z6E0
uniprot id: G3QKQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9595:RGS1
gene id: 9595:RGS1
uniprot id: G3QFH9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9595:ETV5
gene id: 9595:ETV5
uniprot id: G3QH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:TFF2
gene id: 9595:TFF2
uniprot id: G3RFF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FOXP2
gene id: 9595:FOXP2
uniprot id: Q8MJ99
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).

9595:FES
gene id: 9595:FES
uniprot id: A0A2I2Y925
uniprot id: G3QYQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9595:ASIC4
gene id: 9595:ASIC4
uniprot id: G3QJT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9595:DCAF1
gene id: 9595:DCAF1
uniprot id: A0A2I2ZF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9595:ENPP4
gene id: 9595:ENPP4
uniprot id: G3QWX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9595:WASF3
gene id: 9595:WASF3
uniprot id: A0A2I2ZQA9
uniprot id: G3R9W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:SLCO6A1
gene id: 9595:SLCO6A1
uniprot id: G3RFJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ARF4
gene id: 9595:ARF4
uniprot id: G3QDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9595:HDAC9
gene id: 9595:HDAC9
uniprot id: G3RCU7
uniprot id: G3S8P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9595:SAXO1
gene id: 9595:SAXO1
uniprot id: G3RYC0
names: Similarity
messages: Belongs to the FAM154 family.

9595:CDK14
gene id: 9595:CDK14
uniprot id: A0A2I2YAD6
uniprot id: A0A2I2ZU98
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:EMC3
gene id: 9595:EMC3
uniprot id: A0A2I2ZL94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9595:EPS8
gene id: 9595:EPS8
uniprot id: G3S4A2
names: Similarity
messages: Belongs to the EPS8 family.

9595:AMFR
gene id: 9595:AMFR
uniprot id: A0A2I2YQY4
names: Subcellular Location Annotation
messages: Membrane

9595:PTTG1
gene id: 9595:PTTG1
uniprot id: G3RL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9595:NAV1
gene id: 9595:NAV1
uniprot id: A0A2I2Z906
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9595:CDCA7
gene id: 9595:CDCA7
uniprot id: G3QH14
uniprot id: G3S418
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:TADA1
gene id: 9595:TADA1
uniprot id: G3QYP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9595:GAB1
gene id: 9595:GAB1
uniprot id: G3QCS4
names: Similarity
messages: Belongs to the GAB family.

9595:FAM210B
gene id: 9595:FAM210B
uniprot id: A0A2I2ZUQ0
names: Similarity
messages: Belongs to the FAM210 family.

9595:BTN2A1
gene id: 9595:BTN2A1
uniprot id: G3RF61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9595:FOPNL
gene id: 9595:FOPNL
uniprot id: A0A2I2YNC7
uniprot id: A0A2I2ZGE5
uniprot id: G3SEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9595:LOC101132862
gene id: 9595:LOC101132862
uniprot id: G3QV25
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:SPACA5
gene id: 9595:SPACA5
uniprot id: G3SBU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9595:SLC29A2
gene id: 9595:SLC29A2
uniprot id: G3QYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9595:IAPP
gene id: 9595:IAPP
uniprot id: G3RQX9
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9595:F8
gene id: 9595:F8
uniprot id: G3QM23
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:NKIRAS1
gene id: 9595:NKIRAS1
uniprot id: G3RC04
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9595:PDE6A
gene id: 9595:PDE6A
uniprot id: G3R565
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:LBH
gene id: 9595:LBH
uniprot id: A0A2I2ZWR3
uniprot id: G3QGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9595:SLC12A9
gene id: 9595:SLC12A9
uniprot id: G3QGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9595:STMN4
gene id: 9595:STMN4
uniprot id: G3QLD5
uniprot id: G3SAS9
names: Similarity
messages: Belongs to the stathmin family.

9595:TEX261
gene id: 9595:TEX261
uniprot id: G3R299
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9595:G6PC3
gene id: 9595:G6PC3
uniprot id: G3R4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9595:PDZK1IP1
gene id: 9595:PDZK1IP1
uniprot id: G3R7X9
names: Subcellular Location Annotation
messages: Membrane

9595:RAB9A
gene id: 9595:RAB9A
uniprot id: G3SA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9595:AMOT
gene id: 9595:AMOT
uniprot id: G3R6B8
names: Similarity
messages: Belongs to the angiomotin family.

9595:ACSL5
gene id: 9595:ACSL5
uniprot id: G3QPL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9595:ATP2A2
gene id: 9595:ATP2A2
uniprot id: A0A2I2YDK6
uniprot id: A0A2I2YIY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9595:STK11IP
gene id: 9595:STK11IP
uniprot id: G3QRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9595:CLP1
gene id: 9595:CLP1
uniprot id: G3SDE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9595:REEP3
gene id: 9595:REEP3
uniprot id: G3QYU2
uniprot id: G3RNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9595:ACYP2
gene id: 9595:ACYP2
uniprot id: A0A2I2Y4T3
uniprot id: G3R691
names: Similarity
messages: Belongs to the acylphosphatase family.

9595:KCNAB3
gene id: 9595:KCNAB3
uniprot id: G3QUA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9595:BARHL1
gene id: 9595:BARHL1
uniprot id: G3QZ20
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101153190
gene id: 9595:LOC101153190
uniprot id: G3RGS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9595:SLC15A1
gene id: 9595:SLC15A1
uniprot id: G3RG12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9595:H1-1
gene id: 9595:H1-1
uniprot id: A0A2I2YJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:PXMP4
gene id: 9595:PXMP4
uniprot id: A0A2I2Y5V8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9595:MARCHF4
gene id: 9595:MARCHF4
uniprot id: G3QD63
names: Subcellular Location Annotation
messages: Membrane

9595:DDRGK1
gene id: 9595:DDRGK1
uniprot id: G3R061
names: Similarity
messages: Belongs to the DDRGK1 family.

9595:FOXI1
gene id: 9595:FOXI1
uniprot id: G3S6N6
names: Subcellular Location Annotation
messages: Nucleus

9595:THBS4
gene id: 9595:THBS4
uniprot id: G3SD95
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:BDKRB1
gene id: 9595:BDKRB1
uniprot id: G3RCB1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9595:IL1RL2
gene id: 9595:IL1RL2
uniprot id: G3QLE3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:LOC101135980
gene id: 9595:LOC101135980
uniprot id: G3R2C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:SKA1
gene id: 9595:SKA1
uniprot id: G3RKH3
names: Similarity
messages: Belongs to the SKA1 family.

9595:NDFIP1
gene id: 9595:NDFIP1
uniprot id: G3QQB6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9595:MAPK4
gene id: 9595:MAPK4
uniprot id: G3RXT3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9595:CHAT
gene id: 9595:CHAT
uniprot id: A0A2I2YN38
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:EIF1
gene id: 9595:EIF1
uniprot id: G3SHY9
names: Similarity
messages: Belongs to the SUI1 family.

9595:PPP4R3B
gene id: 9595:PPP4R3B
uniprot id: A0A2I2YLP1
uniprot id: A0A2I2ZQH2
uniprot id: G3RFF6
names: Similarity
messages: Belongs to the SMEK family.

9595:MRPL10
gene id: 9595:MRPL10
uniprot id: G3RH60
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9595:ACTG2
gene id: 9595:ACTG2
uniprot id: A0A2I2YVV7
names: Similarity
messages: Belongs to the actin family.

9595:B4GALT4
gene id: 9595:B4GALT4
uniprot id: G3R771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:RFX3
gene id: 9595:RFX3
uniprot id: G3QMK1
names: Subcellular Location Annotation
messages: Nucleus

9595:PLD1
gene id: 9595:PLD1
uniprot id: A0A2I2ZEZ5
uniprot id: G3QXY7
names: Similarity
messages: Belongs to the phospholipase D family.

9595:MDN1
gene id: 9595:MDN1
uniprot id: G3SD94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

9595:DUSP5
gene id: 9595:DUSP5
uniprot id: G3QJK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9595:TMEM176B
gene id: 9595:TMEM176B
uniprot id: G3RK31
names: Similarity
messages: Belongs to the TMEM176 family.

9595:SLC66A3
gene id: 9595:SLC66A3
uniprot id: A0A2I2Z450
uniprot id: G3QGR7
names: Subcellular Location Annotation
messages: Membrane

9595:SLFN5
gene id: 9595:SLFN5
uniprot id: A0A2I2ZFU0
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9595:GAPVD1
gene id: 9595:GAPVD1
uniprot id: A0A2I2YB47
uniprot id: A0A2I2YFX9
uniprot id: A0A2I2Z1H9
uniprot id: G3QGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9595:KCNMB1
gene id: 9595:KCNMB1
uniprot id: G3QW55
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9595:LOC101150282
gene id: 9595:LOC101150282
uniprot id: G3SCE6
names: Subcellular Location Annotation
messages: Membrane

9595:FLOT2
gene id: 9595:FLOT2
uniprot id: G3S498
uniprot id: G3SC78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

9595:TSC22D3
gene id: 9595:TSC22D3
uniprot id: G3QR51
uniprot id: G3S667
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:SLC17A3
gene id: 9595:SLC17A3
uniprot id: G3SJE4
names: Subcellular Location Annotation
messages: Membrane

9595:MRPL40
gene id: 9595:MRPL40
uniprot id: G3R9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9595:CAMK1G
gene id: 9595:CAMK1G
uniprot id: G3QFX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:NPM2
gene id: 9595:NPM2
uniprot id: G3QVX8
names: Similarity
messages: Belongs to the nucleoplasmin family.

9595:GJD4
gene id: 9595:GJD4
uniprot id: G3QST2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:TNFSF12
gene id: 9595:TNFSF12
uniprot id: A0A2I2YXR1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:PCLAF
gene id: 9595:PCLAF
uniprot id: A0A2I2Z3H6
uniprot id: G3QM99
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9595:DDX3X
gene id: 9595:DDX3X
uniprot id: A0A2I2ZYD9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:CORO1C
gene id: 9595:CORO1C
uniprot id: G3RLP4
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:CRYL1
gene id: 9595:CRYL1
uniprot id: G3R639
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9595:MYRF
gene id: 9595:MYRF
uniprot id: G3R9Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9595:ZNF287
gene id: 9595:ZNF287
uniprot id: G3SF77
names: Subcellular Location Annotation
messages: Nucleus

9595:NAALADL2
gene id: 9595:NAALADL2
uniprot id: A0A2I2Y582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9595:MAN2A1
gene id: 9595:MAN2A1
uniprot id: G3QGR6
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:ASXL2
gene id: 9595:ASXL2
uniprot id: G3R5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9595:GPR180
gene id: 9595:GPR180
uniprot id: G3RVJ7
names: Subcellular Location Annotation
messages: Membrane

9595:KEG83 p09
gene id: 9595:KEG83_p09
uniprot id: G3SGQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9595:DNAJB14
gene id: 9595:DNAJB14
uniprot id: G3QD47
names: Subcellular Location Annotation
messages: Membrane

9595:DNMBP
gene id: 9595:DNMBP
uniprot id: A0A2I2Z4Z2
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: cytoskeleton

9595:SEC61A1
gene id: 9595:SEC61A1
uniprot id: G3RUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TREH
gene id: 9595:TREH
uniprot id: G3RH50
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9595:RPL17
gene id: 9595:RPL17
uniprot id: G3RX17
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9595:MGRN1
gene id: 9595:MGRN1
uniprot id: A0A2I2YL88
uniprot id: A0A2I2Z001
uniprot id: A0A2I2ZPB0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9595:PROKR2
gene id: 9595:PROKR2
uniprot id: G3RE80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:MRS2
gene id: 9595:MRS2
uniprot id: G3R146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9595:STAT6
gene id: 9595:STAT6
uniprot id: G3QGF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9595:ZDHHC1
gene id: 9595:ZDHHC1
uniprot id: G3S107
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:P4HA1
gene id: 9595:P4HA1
uniprot id: A0A2I2Z3V0
uniprot id: A0A2I2Z806
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9595:INO80D
gene id: 9595:INO80D
uniprot id: G3RHR4
names: Subcellular Location Annotation
messages: Nucleus

9595:GMFB
gene id: 9595:GMFB
uniprot id: A0A2I2Z891
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9595:LOC101148806
gene id: 9595:LOC101148806
uniprot id: G3QEL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:UTP14A
gene id: 9595:UTP14A
uniprot id: G3RG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9595:MRGPRE
gene id: 9595:MRGPRE
uniprot id: G3QF42
names: Subcellular Location Annotation
messages: Cell membrane

9595:SERINC3
gene id: 9595:SERINC3
uniprot id: G3RHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:LAMTOR1
gene id: 9595:LAMTOR1
uniprot id: A0A2I2YP21
uniprot id: G3R9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:ATF1
gene id: 9595:ATF1
uniprot id: A0A2I2ZEL8
names: Subcellular Location Annotation
messages: Nucleus

9595:BID
gene id: 9595:BID
uniprot id: G3R4T6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:CBX7
gene id: 9595:CBX7
uniprot id: G3QQA9
names: Subcellular Location Annotation
messages: Nucleus

9595:SPPL2A
gene id: 9595:SPPL2A
uniprot id: G3RBH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:IL17F
gene id: 9595:IL17F
uniprot id: G3QQN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9595:SCN4A
gene id: 9595:SCN4A
uniprot id: G3R9Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:FZD3
gene id: 9595:FZD3
uniprot id: G3RNY6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ITGB1
gene id: 9595:ITGB1
uniprot id: G3QTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9595:RPL10A
gene id: 9595:RPL10A
uniprot id: G3RV13
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9595:ALG14
gene id: 9595:ALG14
uniprot id: G3QQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

9595:DRD1
gene id: 9595:DRD1
uniprot id: A0A2I2YZU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9595:SCG5
gene id: 9595:SCG5
uniprot id: G3RJS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9595:RAP2A
gene id: 9595:RAP2A
uniprot id: A0A2I2YVG8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9595:ATG4C
gene id: 9595:ATG4C
uniprot id: G3QWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9595:GSTO2
gene id: 9595:GSTO2
uniprot id: G3QED5
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9595:ACTL7A
gene id: 9595:ACTL7A
uniprot id: G3S9F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9595:LOC101153683
gene id: 9595:LOC101153683
uniprot id: G3RSY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GHR
gene id: 9595:GHR
uniprot id: A0A2I2Y9H0
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9595:TATDN1
gene id: 9595:TATDN1
uniprot id: A0A2I2ZH97
uniprot id: G3S4C4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9595:MMS19
gene id: 9595:MMS19
uniprot id: G3QKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9595:PTGR1
gene id: 9595:PTGR1
uniprot id: A0A2I2Z9P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9595:DNASE1L1
gene id: 9595:DNASE1L1
uniprot id: G3QD27
names: Similarity
messages: Belongs to the DNase I family.

9595:TMEM144
gene id: 9595:TMEM144
uniprot id: G3RLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9595:INHBE
gene id: 9595:INHBE
uniprot id: G3QJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:FHL5
gene id: 9595:FHL5
uniprot id: G3QNM5
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9595:LOC101125134
gene id: 9595:LOC101125134
uniprot id: G3SDT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:SLC18A3
gene id: 9595:SLC18A3
uniprot id: G3SKN2
names: Subcellular Location Annotation
messages: Membrane

9595:ACHE
gene id: 9595:ACHE
uniprot id: G3QGN3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9595:PTPRE
gene id: 9595:PTPRE
uniprot id: A0A2I2Z3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9595:GCHFR
gene id: 9595:GCHFR
uniprot id: G3QCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9595:HTR1B
gene id: 9595:HTR1B
uniprot id: G3RV57
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9595:ADAMTS12
gene id: 9595:ADAMTS12
uniprot id: G3R2M2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:TSSC4
gene id: 9595:TSSC4
uniprot id: G3QX83
names: Similarity
messages: Belongs to the TSSC4 family.

9595:FLNC
gene id: 9595:FLNC
uniprot id: A0A2I2Y5W8
uniprot id: G3S085
names: Similarity
messages: Belongs to the filamin family.

9595:UCP3
gene id: 9595:UCP3
uniprot id: G3QDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:CDC20B
gene id: 9595:CDC20B
uniprot id: A0A2I2ZT37
uniprot id: G3RQG4
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9595:IL1R1
gene id: 9595:IL1R1
uniprot id: G3QLD8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:BZW1
gene id: 9595:BZW1
uniprot id: A0A2I2ZR48
uniprot id: G3SA22
names: Similarity
messages: Belongs to the BZW family.

9595:ISOC1
gene id: 9595:ISOC1
uniprot id: G3RAI7
names: Similarity
messages: Belongs to the isochorismatase family.

9595:GGPS1
gene id: 9595:GGPS1
uniprot id: G3R0L0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9595:CHRNA2
gene id: 9595:CHRNA2
uniprot id: G3RHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:CDH20
gene id: 9595:CDH20
uniprot id: G3QVJ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:MED12L
gene id: 9595:MED12L
uniprot id: G3RHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9595:FAM228A
gene id: 9595:FAM228A
uniprot id: A0A2I2Y7P5
uniprot id: A0A2I2ZA00
names: Similarity
messages: Belongs to the FAM228 family.

9595:NCOA7
gene id: 9595:NCOA7
uniprot id: G3S9J5
names: Similarity
messages: Belongs to the OXR1 family.

9595:TRAF6
gene id: 9595:TRAF6
uniprot id: G3QST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9595:HTATIP2
gene id: 9595:HTATIP2
uniprot id: A1YER2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA (By similarity).
messages: Nucleus envelope
messages: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity).

9595:NDUFA12
gene id: 9595:NDUFA12
uniprot id: Q0MQ86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:PLRG1
gene id: 9595:PLRG1
uniprot id: G3RZI1
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9595:RCAN3
gene id: 9595:RCAN3
uniprot id: G3RC15
names: Similarity
messages: Belongs to the RCAN family.

9595:BRINP2
gene id: 9595:BRINP2
uniprot id: G3QGV4
names: Similarity
messages: Belongs to the BRINP family.

9595:PTPRN
gene id: 9595:PTPRN
uniprot id: A0A2I2ZUY9
uniprot id: G3R874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9595:FOXA3
gene id: 9595:FOXA3
uniprot id: G3QMZ7
names: Subcellular Location Annotation
messages: Nucleus

9595:IPO11
gene id: 9595:IPO11
uniprot id: G3QL52
names: Subcellular Location Annotation
messages: Cytoplasm

9595:EIF2D
gene id: 9595:EIF2D
uniprot id: A0A2I2ZR02
uniprot id: G3RGZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9595:PDE8A
gene id: 9595:PDE8A
uniprot id: G3RN05
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:APLP2
gene id: 9595:APLP2
uniprot id: G3R2X8
uniprot id: G3RU73
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CX3CL1
gene id: 9595:CX3CL1
uniprot id: G3QE79
names: Subcellular Location Annotation
messages: Secreted

9595:GNAI1
gene id: 9595:GNAI1
uniprot id: G3QYF3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:MAGOHB
gene id: 9595:MAGOHB
uniprot id: A0A2I2Y2C4
uniprot id: A0A2I2YIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9595:KIF4A
gene id: 9595:KIF4A
uniprot id: G3S0T3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:XPOT
gene id: 9595:XPOT
uniprot id: G3S3K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9595:GFOD2
gene id: 9595:GFOD2
uniprot id: G3RQ06
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9595:HENMT1
gene id: 9595:HENMT1
uniprot id: G3RVN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9595:PAMR1
gene id: 9595:PAMR1
uniprot id: G3REC8
uniprot id: G3RYC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RNF182
gene id: 9595:RNF182
uniprot id: A0A2I2Y7J3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9595:ACTBL2
gene id: 9595:ACTBL2
uniprot id: A0A2I2ZEN8
names: Similarity
messages: Belongs to the actin family.

9595:LOC101132260
gene id: 9595:LOC101132260
uniprot id: A0A2I2YFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FGF13
gene id: 9595:FGF13
uniprot id: A0A2I2YT95
uniprot id: G3R343
uniprot id: G3RVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9595:NXPH1
gene id: 9595:NXPH1
uniprot id: A0A2I2Z2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9595:EEF1AKMT1
gene id: 9595:EEF1AKMT1
uniprot id: G3RL82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9595:PSMB3
gene id: 9595:PSMB3
uniprot id: G3QVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:TALDO1
gene id: 9595:TALDO1
uniprot id: G3R5A9
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9595:RPRD1A
gene id: 9595:RPRD1A
uniprot id: A0A2I2YFV1
uniprot id: G3QWP7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9595:SLC30A10
gene id: 9595:SLC30A10
uniprot id: G3R250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:YIPF1
gene id: 9595:YIPF1
uniprot id: G3RHA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9595:AMT
gene id: 9595:AMT
uniprot id: G3RNZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9595:UNC45B
gene id: 9595:UNC45B
uniprot id: G3SGT4
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9595:ARPC2
gene id: 9595:ARPC2
uniprot id: A0A2I2ZVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9595:SLX4
gene id: 9595:SLX4
uniprot id: G3RKC9
names: Similarity
messages: Belongs to the SLX4 family.

9595:TSFM
gene id: 9595:TSFM
uniprot id: G3QGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9595:LSM2
gene id: 9595:LSM2
uniprot id: G3R6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9595:CNTNAP4
gene id: 9595:CNTNAP4
uniprot id: A0A2I2Y548
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LAMTOR3
gene id: 9595:LAMTOR3
uniprot id: G3QFN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9595:WNK3
gene id: 9595:WNK3
uniprot id: G3R7G3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9595:MBOAT4
gene id: 9595:MBOAT4
uniprot id: G3QLI0
names: Subcellular Location Annotation
messages: Membrane

9595:BRS3
gene id: 9595:BRS3
uniprot id: G3QL90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9595:RPS9
gene id: 9595:RPS9
uniprot id: G3S5K1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9595:ASIC5
gene id: 9595:ASIC5
uniprot id: G3SHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9595:RTCB
gene id: 9595:RTCB
uniprot id: G3R6Z5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9595:WASHC3
gene id: 9595:WASHC3
uniprot id: G3RG72
names: Similarity
messages: Belongs to the CCDC53 family.

9595:ACSS1
gene id: 9595:ACSS1
uniprot id: A0A2I2YQX6
uniprot id: G3QG16
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:INTS8
gene id: 9595:INTS8
uniprot id: G3QRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9595:TM4SF5
gene id: 9595:TM4SF5
uniprot id: G3R744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:PTP4A2
gene id: 9595:PTP4A2
uniprot id: A0A2I2ZXM0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9595:ZNF202
gene id: 9595:ZNF202
uniprot id: G3QVH3
names: Subcellular Location Annotation
messages: Nucleus

9595:VPS37B
gene id: 9595:VPS37B
uniprot id: G3QQI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:TRMT1L
gene id: 9595:TRMT1L
uniprot id: G3R7Y9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9595:ATXN1L
gene id: 9595:ATXN1L
uniprot id: A0A2I2ZDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9595:MED7
gene id: 9595:MED7
uniprot id: G3QJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9595:CNIH2
gene id: 9595:CNIH2
uniprot id: G3R2S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9595:TBL1X
gene id: 9595:TBL1X
uniprot id: G3QX50
names: Similarity
messages: Belongs to the WD repeat EBI family.

9595:TMEM189
gene id: 9595:TMEM189
uniprot id: G3SK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9595:SYNE4
gene id: 9595:SYNE4
uniprot id: G3QF10
names: Similarity
messages: Belongs to the nesprin family.

9595:VPS8
gene id: 9595:VPS8
uniprot id: A0A2I2ZG74
names: Similarity
messages: Belongs to the VPS8 family.

9595:GCN1
gene id: 9595:GCN1
uniprot id: G3QP32
names: Similarity
messages: Belongs to the GCN1 family.

9595:CSRNP1
gene id: 9595:CSRNP1
uniprot id: G3RKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9595:FAM3C
gene id: 9595:FAM3C
uniprot id: G3RJZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:MRPL32
gene id: 9595:MRPL32
uniprot id: G3S9M7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9595:HPS5
gene id: 9595:HPS5
uniprot id: G3RTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9595:A2ML1
gene id: 9595:A2ML1
uniprot id: G3QPP3
uniprot id: G3SA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9595:ZSCAN12
gene id: 9595:ZSCAN12
uniprot id: A0A2I2YPJ7
names: Subcellular Location Annotation
messages: Nucleus

9595:ADGRA2
gene id: 9595:ADGRA2
uniprot id: A0A2I2Z1R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9595:POLR3H
gene id: 9595:POLR3H
uniprot id: A0A2I2ZTU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9595:EMP3
gene id: 9595:EMP3
uniprot id: G3RGJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9595:ADGRG7
gene id: 9595:ADGRG7
uniprot id: A0A2I2YIM5
uniprot id: G3R5N7
names: Subcellular Location Annotation
messages: Membrane

9595:SUB1
gene id: 9595:SUB1
uniprot id: A0A2I2YAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9595:MAP2K1
gene id: 9595:MAP2K1
uniprot id: G3QM92
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ADGRG6
gene id: 9595:ADGRG6
uniprot id: A0A2I2ZJJ8
uniprot id: G3QJJ6
uniprot id: G3SC49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:PIGV
gene id: 9595:PIGV
uniprot id: G3QQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9595:ITM2B
gene id: 9595:ITM2B
uniprot id: G3QV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9595:ACTL10
gene id: 9595:ACTL10
uniprot id: A0A2I2Z9K7
names: Similarity
messages: Belongs to the actin family.

9595:RAB3GAP1
gene id: 9595:RAB3GAP1
uniprot id: G3RGG4
uniprot id: G3SA53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9595:KCNG4
gene id: 9595:KCNG4
uniprot id: G3QGS1
names: Subcellular Location Annotation
messages: Membrane

9595:VWC2
gene id: 9595:VWC2
uniprot id: G3R5J1
names: Subcellular Location Annotation
messages: Synapse

9595:DNAH8
gene id: 9595:DNAH8
uniprot id: G3RF10
names: Similarity
messages: Belongs to the dynein heavy chain family.

9595:ARF6
gene id: 9595:ARF6
uniprot id: A0A2I2Z417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9595:ALDOC
gene id: 9595:ALDOC
uniprot id: G3R2M4
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9595:GRPEL1
gene id: 9595:GRPEL1
uniprot id: G3RJT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9595:VSIG1
gene id: 9595:VSIG1
uniprot id: G3R4U8
uniprot id: G3RZ93
names: Subcellular Location Annotation
messages: Membrane

9595:MIEF1
gene id: 9595:MIEF1
uniprot id: G3SJU6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:RPS6KA6
gene id: 9595:RPS6KA6
uniprot id: G3RSV7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:CALB1
gene id: 9595:CALB1
uniprot id: G3QQH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9595:SYT1
gene id: 9595:SYT1
uniprot id: G3S3Z1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9595:CELF4
gene id: 9595:CELF4
uniprot id: G3RDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9595:ADGRE5
gene id: 9595:ADGRE5
uniprot id: A0A2I2YIG6
uniprot id: A0A2I2YJG6
uniprot id: A0A2I2ZX84
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SMIM8
gene id: 9595:SMIM8
uniprot id: G3QJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9595:ENO4
gene id: 9595:ENO4
uniprot id: G3SJB9
names: Similarity
messages: Belongs to the enolase family.

9595:SLC40A1
gene id: 9595:SLC40A1
uniprot id: A0A2I2ZHV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9595:HTRA4
gene id: 9595:HTRA4
uniprot id: G3QTA2
names: Similarity
messages: Belongs to the peptidase S1C family.

9595:MAN2C1
gene id: 9595:MAN2C1
uniprot id: A0A2I2ZC02
uniprot id: G3RFT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

9595:LIG3
gene id: 9595:LIG3
uniprot id: A0A2I2ZDY6
uniprot id: G3RTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9595:BDKRB2
gene id: 9595:BDKRB2
uniprot id: G3RCA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9595:SLC25A38
gene id: 9595:SLC25A38
uniprot id: G3RCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9595:PGM2L1
gene id: 9595:PGM2L1
uniprot id: G3QXX0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9595:HTR3A
gene id: 9595:HTR3A
uniprot id: A0A2I2ZB92
uniprot id: G3RFI3
uniprot id: G3S4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:S100Z
gene id: 9595:S100Z
uniprot id: G3SJ08
names: Similarity
messages: Belongs to the S-100 family.

9595:LOC101138014
gene id: 9595:LOC101138014
uniprot id: G3RV10
names: Subcellular Location Annotation
messages: Membrane

9595:CELF6
gene id: 9595:CELF6
uniprot id: A0A2I2ZLS0
uniprot id: G3RZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9595:TSEN15
gene id: 9595:TSEN15
uniprot id: A0A2I2ZQX4
uniprot id: G3RIB6
names: Similarity
messages: Belongs to the SEN15 family.

9595:TMEM65
gene id: 9595:TMEM65
uniprot id: A0A2I2ZLW7
names: Subcellular Location Annotation
messages: Membrane

9595:PSME2
gene id: 9595:PSME2
uniprot id: G3S8N8
names: Similarity
messages: Belongs to the PA28 family.

9595:MED21
gene id: 9595:MED21
uniprot id: G3RJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9595:SLC6A20
gene id: 9595:SLC6A20
uniprot id: G3QI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:IGF1
gene id: 9595:IGF1
uniprot id: A0A2I2YEV2
uniprot id: A0A2I2Z8G5
uniprot id: A0A2I2ZCP6
uniprot id: G3QQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9595:PSMB7
gene id: 9595:PSMB7
uniprot id: G3R8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9595:PPP3CB
gene id: 9595:PPP3CB
uniprot id: A0A2I2Y6B3
uniprot id: G3SGD5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9595:PPP4R3C
gene id: 9595:PPP4R3C
uniprot id: G3S742
names: Similarity
messages: Belongs to the SMEK family.

9595:ERLIN2
gene id: 9595:ERLIN2
uniprot id: A0A2I2YUD9
uniprot id: G3RAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9595:GDF10
gene id: 9595:GDF10
uniprot id: G3QSX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9595:SEPTIN4
gene id: 9595:SEPTIN4
uniprot id: A0A2I2ZB66
uniprot id: G3RD82
uniprot id: G3RN19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:LIPM
gene id: 9595:LIPM
uniprot id: G3QWK0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:TRPC7
gene id: 9595:TRPC7
uniprot id: A0A2I2Y8X9
uniprot id: A0A2I2YFL8
uniprot id: A0A2I2YSA4
names: Subcellular Location Annotation
messages: Membrane

9595:LOC109025290
gene id: 9595:LOC109025290
uniprot id: A0A2I2YPE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9595:TOMM20
gene id: 9595:TOMM20
uniprot id: G3SFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:CCNB3
gene id: 9595:CCNB3
uniprot id: G3RQC9
names: Similarity
messages: Belongs to the cyclin family.

9595:GLI1
gene id: 9595:GLI1
uniprot id: A0A2I2YT57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9595:ALDH3A2
gene id: 9595:ALDH3A2
uniprot id: A0A2I2Z075
uniprot id: G3QXF5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:SYN1
gene id: 9595:SYN1
uniprot id: G3R034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9595:NEUROD2
gene id: 9595:NEUROD2
uniprot id: G3SDZ7
names: Subcellular Location Annotation
messages: Nucleus

9595:PDLIM3
gene id: 9595:PDLIM3
uniprot id: A0A2I2ZNC2
names: Subcellular Location Annotation
messages: Z line

9595:HTN1
gene id: 9595:HTN1
uniprot id: G3QQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9595:CTSZ
gene id: 9595:CTSZ
uniprot id: G3RKE4
names: Similarity
messages: Belongs to the peptidase C1 family.

9595:DOP1B
gene id: 9595:DOP1B
uniprot id: G3QMJ6
names: Similarity
messages: Belongs to the dopey family.

9595:CPB1
gene id: 9595:CPB1
uniprot id: G3QRF4
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:CLDN9
gene id: 9595:CLDN9
uniprot id: A0A2I2Z2C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:DIPK2A
gene id: 9595:DIPK2A
uniprot id: G3RGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9595:PTGES
gene id: 9595:PTGES
uniprot id: A0A2I2YMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9595:LOC101125803
gene id: 9595:LOC101125803
uniprot id: A0A1B1R4C2
uniprot id: G3SKC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9595:ITM2A
gene id: 9595:ITM2A
uniprot id: G3RPS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9595:TPPP2
gene id: 9595:TPPP2
uniprot id: A0A2I2YJM1
names: Similarity
messages: Belongs to the TPPP family.

9595:EIF1AD
gene id: 9595:EIF1AD
uniprot id: G3R7Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9595:EXOSC3
gene id: 9595:EXOSC3
uniprot id: A0A2I2YV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9595:RHBDD1
gene id: 9595:RHBDD1
uniprot id: A0A2I2Z389
names: Subcellular Location Annotation
messages: Membrane

9595:TM4SF20
gene id: 9595:TM4SF20
uniprot id: G3QDH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:LOC101152943
gene id: 9595:LOC101152943
uniprot id: G3R406
names: Subcellular Location Annotation
messages: Membrane

9595:USP20
gene id: 9595:USP20
uniprot id: G3QLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9595:SLC9A9
gene id: 9595:SLC9A9
uniprot id: G3SKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9595:ADAMTS6
gene id: 9595:ADAMTS6
uniprot id: G3RJ61
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:PIK3C3
gene id: 9595:PIK3C3
uniprot id: A0A2I2ZRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9595:CRBN
gene id: 9595:CRBN
uniprot id: A0A2I2YW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9595:FAM229A
gene id: 9595:FAM229A
uniprot id: A0A2I2ZJD7
names: Similarity
messages: Belongs to the FAM229 family.

9595:S100A2
gene id: 9595:S100A2
uniprot id: G3RYQ2
names: Similarity
messages: Belongs to the S-100 family.

9595:SUMO1
gene id: 9595:SUMO1
uniprot id: G3S6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9595:LOC101128585
gene id: 9595:LOC101128585
uniprot id: A0A2I2ZHY0
uniprot id: A0A2I2ZLX5
uniprot id: A0A2I2ZQG9
uniprot id: A0A2I2ZXP0
uniprot id: G3RPF6
uniprot id: G3S8W3
uniprot id: G3SB82
uniprot id: G3SDQ1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9595:SLC66A1
gene id: 9595:SLC66A1
uniprot id: G3QE42
names: Subcellular Location Annotation
messages: Membrane

9595:CCNC
gene id: 9595:CCNC
uniprot id: A0A2I2YSZ3
uniprot id: G3QWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9595:LOC101131824
gene id: 9595:LOC101131824
uniprot id: G3S4C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC6A6
gene id: 9595:SLC6A6
uniprot id: A0A2I2ZC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9595:GRK6
gene id: 9595:GRK6
uniprot id: G3R2J6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9595:IDI2
gene id: 9595:IDI2
uniprot id: G3RC34
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9595:NDRG1
gene id: 9595:NDRG1
uniprot id: G3RGT6
names: Similarity
messages: Belongs to the NDRG family.

9595:SPRY2
gene id: 9595:SPRY2
uniprot id: G3R6C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

9595:LOC101149901
gene id: 9595:LOC101149901
uniprot id: G3R0E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CCR4
gene id: 9595:CCR4
uniprot id: G3RC17
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:HMBOX1
gene id: 9595:HMBOX1
uniprot id: A0A2I2ZKJ3
names: Subcellular Location Annotation
messages: Nucleus

9595:MBL2
gene id: 9595:MBL2
uniprot id: Q66S60
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

9595:RAD9B
gene id: 9595:RAD9B
uniprot id: A0A2I2YRP1
names: Similarity
messages: Belongs to the rad9 family.

9595:MRTO4
gene id: 9595:MRTO4
uniprot id: G3QE40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9595:FSCN3
gene id: 9595:FSCN3
uniprot id: G3RKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9595:CEBPB
gene id: 9595:CEBPB
uniprot id: A0A2I2ZBE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9595:NAT10
gene id: 9595:NAT10
uniprot id: G3RF58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9595:CLEC16A
gene id: 9595:CLEC16A
uniprot id: G3RDW4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9595:GABRA3
gene id: 9595:GABRA3
uniprot id: G3SKG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:LHX1
gene id: 9595:LHX1
uniprot id: G3QJR1
names: Subcellular Location Annotation
messages: Nucleus

9595:DGKZ
gene id: 9595:DGKZ
uniprot id: A0A2I2Y9C5
uniprot id: G3S053
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9595:LOC101127636
gene id: 9595:LOC101127636
uniprot id: G3R782
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:ABI2
gene id: 9595:ABI2
uniprot id: A0A2I2ZFI4
uniprot id: A0A2I2ZKM8
uniprot id: A0A2I2ZPP2
uniprot id: A0A2I2ZWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9595:LOC101139132
gene id: 9595:LOC101139132
uniprot id: A0A2I2YNJ2
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101150743
gene id: 9595:LOC101150743
uniprot id: G3R4G4
names: Similarity
messages: Belongs to the NipSnap family.

9595:NPR2
gene id: 9595:NPR2
uniprot id: G3R6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9595:STAT1
gene id: 9595:STAT1
uniprot id: A0A2I2YUU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9595:AGO1
gene id: 9595:AGO1
uniprot id: G3QLB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9595:RPL35A
gene id: 9595:RPL35A
uniprot id: G3RZ05
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9595:LOC101151967
gene id: 9595:LOC101151967
uniprot id: G3RNK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:LOC101136057
gene id: 9595:LOC101136057
uniprot id: G3S7Z1
names: Subcellular Location Annotation
messages: Membrane

9595:GLYATL3
gene id: 9595:GLYATL3
uniprot id: G3S0M6
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9595:CD2
gene id: 9595:CD2
uniprot id: G3QRA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CLVS1
gene id: 9595:CLVS1
uniprot id: G3QXB8
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9595:RPL23
gene id: 9595:RPL23
uniprot id: G3SHW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9595:LDB2
gene id: 9595:LDB2
uniprot id: A0A2I2ZYG9
names: Similarity
messages: Belongs to the LDB family.

9595:DNASE1
gene id: 9595:DNASE1
uniprot id: G3QY47
names: Similarity
messages: Belongs to the DNase I family.

9595:HINT2
gene id: 9595:HINT2
uniprot id: G3R6M3
names: Similarity
messages: Belongs to the HINT family.

9595:TAF9B
gene id: 9595:TAF9B
uniprot id: G3QJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9595:CALCR
gene id: 9595:CALCR
uniprot id: G3R7D7
uniprot id: G3SDU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9595:GPAT4
gene id: 9595:GPAT4
uniprot id: G3RIX8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:AQP2
gene id: 9595:AQP2
uniprot id: G3QSX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:CD3E
gene id: 9595:CD3E
uniprot id: G3QUY7
names: Subcellular Location Annotation
messages: Membrane

9595:CD28
gene id: 9595:CD28
uniprot id: A0A2I2Y8P2
uniprot id: A0A2I2YC79
names: Subcellular Location Annotation
messages: Membrane

9595:PPP2R5C
gene id: 9595:PPP2R5C
uniprot id: A0A2I2YTW3
uniprot id: G3RQ66
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9595:CPSF2
gene id: 9595:CPSF2
uniprot id: G3R814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9595:CD93
gene id: 9595:CD93
uniprot id: A0A2I2ZW40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:NMS
gene id: 9595:NMS
uniprot id: G3RV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9595:TXNL4B
gene id: 9595:TXNL4B
uniprot id: A0A2I2Y9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9595:PPIB
gene id: 9595:PPIB
uniprot id: G3R669
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:RAB3B
gene id: 9595:RAB3B
uniprot id: G3QGS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9595:B4GALNT1
gene id: 9595:B4GALNT1
uniprot id: G3QTX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:ETV3L
gene id: 9595:ETV3L
uniprot id: G3QIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:RDH8
gene id: 9595:RDH8
uniprot id: G3R961
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9595:PRORP
gene id: 9595:PRORP
uniprot id: G3R970
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9595:ZER1
gene id: 9595:ZER1
uniprot id: G3R9I9
names: Similarity
messages: Belongs to the zyg-11 family.

9595:NAGLU
gene id: 9595:NAGLU
uniprot id: G3R5I9
names: Subcellular Location Annotation
messages: Lysosome

9595:TMEM123
gene id: 9595:TMEM123
uniprot id: G3QZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:LY6D
gene id: 9595:LY6D
uniprot id: G3RKS8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LOC101123860
gene id: 9595:LOC101123860
uniprot id: G3RVL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NRM
gene id: 9595:NRM
uniprot id: G3QEL9
uniprot id: G3SBX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9595:SIAH3
gene id: 9595:SIAH3
uniprot id: G3QHJ8
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9595:IFI44L
gene id: 9595:IFI44L
uniprot id: G3RCT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI44 family.
messages: Cytoplasm

9595:TMOD3
gene id: 9595:TMOD3
uniprot id: A0A2I2YS59
names: Subcellular Location Annotation
messages: cytoskeleton

9595:TMOD2
gene id: 9595:TMOD2
uniprot id: G3RI10
names: Subcellular Location Annotation
messages: cytoskeleton

9595:GRIK2
gene id: 9595:GRIK2
uniprot id: A0A2I2Z6L3
uniprot id: G3QD09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:VBP1
gene id: 9595:VBP1
uniprot id: G3RTU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9595:USP44
gene id: 9595:USP44
uniprot id: G3R033
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:STAMBP
gene id: 9595:STAMBP
uniprot id: G3RXN2
names: Similarity
messages: Belongs to the peptidase M67C family.

9595:LOC101129723
gene id: 9595:LOC101129723
uniprot id: A1YF15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity).

9595:LOC101127305
gene id: 9595:LOC101127305
uniprot id: A0A2I2Z4J5
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:DYRK4
gene id: 9595:DYRK4
uniprot id: A0A2I2YDW6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9595:IFT57
gene id: 9595:IFT57
uniprot id: G3QVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9595:PLSCR1
gene id: 9595:PLSCR1
uniprot id: G3RTX1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9595:LOC101143138
gene id: 9595:LOC101143138
uniprot id: G3RIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:GMNN
gene id: 9595:GMNN
uniprot id: G3R2B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9595:CDKN2AIPNL
gene id: 9595:CDKN2AIPNL
uniprot id: G3RZA2
names: Similarity
messages: Belongs to the CARF family.

9595:COL4A2
gene id: 9595:COL4A2
uniprot id: G3RA26
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9595:ITPR3
gene id: 9595:ITPR3
uniprot id: G3RJI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9595:C8A
gene id: 9595:C8A
uniprot id: G3RDM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9595:STS
gene id: 9595:STS
uniprot id: A0A2I2Z9J5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:PSMD9
gene id: 9595:PSMD9
uniprot id: G3QVE5
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9595:CASC3
gene id: 9595:CASC3
uniprot id: G3QQU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9595:MCL1
gene id: 9595:MCL1
uniprot id: A0A2I2YJ87
uniprot id: G3RJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9595:EXOC6
gene id: 9595:EXOC6
uniprot id: G3RRM3
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9595:PPP4R2
gene id: 9595:PPP4R2
uniprot id: G3QZA9
names: Similarity
messages: Belongs to the PPP4R2 family.

9595:STAR
gene id: 9595:STAR
uniprot id: G3QSM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9595:RPS14
gene id: 9595:RPS14
uniprot id: A0A2I2YH05
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9595:BSCL2
gene id: 9595:BSCL2
uniprot id: A0A2I2Z3C5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101127003
gene id: 9595:LOC101127003
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NMUR2
gene id: 9595:NMUR2
uniprot id: G3QV11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9595:NPNT
gene id: 9595:NPNT
uniprot id: A0A2I2ZRN1
uniprot id: G3RCY8
uniprot id: G3S615
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CRYGN
gene id: 9595:CRYGN
uniprot id: G3RFE2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:ADAM9
gene id: 9595:ADAM9
uniprot id: G3QTB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GRPEL2
gene id: 9595:GRPEL2
uniprot id: G3QRN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9595:NPTXR
gene id: 9595:NPTXR
uniprot id: G3SD80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TCEA1
gene id: 9595:TCEA1
uniprot id: G3S7T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9595:LOC101142537
gene id: 9595:LOC101142537
uniprot id: G3RSZ1
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9595:PLN
gene id: 9595:PLN
uniprot id: A0A2I2ZQD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9595:HUS1B
gene id: 9595:HUS1B
uniprot id: G3QWT6
names: Similarity
messages: Belongs to the HUS1 family.

9595:RBM48
gene id: 9595:RBM48
uniprot id: A0A2I2Y675
names: Similarity
messages: Belongs to the RBM48 family.

9595:PLIN3
gene id: 9595:PLIN3
uniprot id: G3S2C7
names: Similarity
messages: Belongs to the perilipin family.

9595:LOC101139253
gene id: 9595:LOC101139253
uniprot id: G3QR02
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9595:CBY2
gene id: 9595:CBY2
uniprot id: A0A2I2YHP7
uniprot id: A0A2I2YY65
uniprot id: G3R3S7
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

9595:CSNK1A1L
gene id: 9595:CSNK1A1L
uniprot id: A0A2I2YZI4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:EME1
gene id: 9595:EME1
uniprot id: G3R6Q2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9595:DAD1
gene id: 9595:DAD1
uniprot id: A0A2I2YH80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9595:ACVRL1
gene id: 9595:ACVRL1
uniprot id: G3QUV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9595:FGD1
gene id: 9595:FGD1
uniprot id: G3QY89
names: Subcellular Location Annotation
messages: cytoskeleton

9595:DGLUCY
gene id: 9595:DGLUCY
uniprot id: G3RH17
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9595:XG
gene id: 9595:XG
uniprot id: A0A2I2YU09
uniprot id: G3RFE6
names: Similarity
messages: Belongs to the CD99 family.

9595:TSNAX
gene id: 9595:TSNAX
uniprot id: A0A2I2Y6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9595:KCNT1
gene id: 9595:KCNT1
uniprot id: G3QR87
uniprot id: G3RMA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:DERL1
gene id: 9595:DERL1
uniprot id: G3R0M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9595:RNF8
gene id: 9595:RNF8
uniprot id: G3RG85
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9595:LOC101149907
gene id: 9595:LOC101149907
uniprot id: G3R1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SPAG7
gene id: 9595:SPAG7
uniprot id: G3R1B3
names: Subcellular Location Annotation
messages: Nucleus

9595:TRABD2A
gene id: 9595:TRABD2A
uniprot id: A0A2I2YXX1
uniprot id: A0A2I2Z6M7
uniprot id: G3QN64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9595:GGT6
gene id: 9595:GGT6
uniprot id: A0A2I2YKH0
uniprot id: G3QU68
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9595:TCTEX1D2
gene id: 9595:TCTEX1D2
uniprot id: G3RBT4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9595:PDK4
gene id: 9595:PDK4
uniprot id: G3QJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:SLIT2
gene id: 9595:SLIT2
uniprot id: A0A2I2Z9V9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:XPO1
gene id: 9595:XPO1
uniprot id: A0A2I2ZAW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9595:SPEN
gene id: 9595:SPEN
uniprot id: G3R8N9
names: Similarity
messages: Belongs to the RRM Spen family.

9595:NGF
gene id: 9595:NGF
uniprot id: Q9N2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Endosome lumen
messages: Homodimer. The homodimer interacts with a single NTRK1 chain. The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity).
messages: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
messages: Secreted

9595:HTN3
gene id: 9595:HTN3
uniprot id: A0A2I2YBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9595:KCNK12
gene id: 9595:KCNK12
uniprot id: A0A2I2YZD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:FGFR1OP2
gene id: 9595:FGFR1OP2
uniprot id: A0A2I2YCV1
uniprot id: G3SEJ1
names: Similarity
messages: Belongs to the SIKE family.

9595:AQP12B
gene id: 9595:AQP12B
uniprot id: G3S3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9595:DGAT2
gene id: 9595:DGAT2
uniprot id: G3QK91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TRAPPC1
gene id: 9595:TRAPPC1
uniprot id: G3QUA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9595:PLA1A
gene id: 9595:PLA1A
uniprot id: G3QKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9595:LOC101154556
gene id: 9595:LOC101154556
uniprot id: G3R7J7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9595:ASB2
gene id: 9595:ASB2
uniprot id: G3RHC1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:TEKT1
gene id: 9595:TEKT1
uniprot id: G3RGY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9595:TMEM9
gene id: 9595:TMEM9
uniprot id: A0A2I2YV69
uniprot id: G3QSN9
names: Similarity
messages: Belongs to the TMEM9 family.

9595:PRR5L
gene id: 9595:PRR5L
uniprot id: G3R0M0
names: Similarity
messages: Belongs to the PROTOR family.

9595:BAP1
gene id: 9595:BAP1
uniprot id: G3RIK2
names: Similarity
messages: Belongs to the peptidase C12 family.

9595:NUBP2
gene id: 9595:NUBP2
uniprot id: G3QTT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9595:TSG101
gene id: 9595:TSG101
uniprot id: G3R4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

9595:SPTY2D1
gene id: 9595:SPTY2D1
uniprot id: G3R4C5
names: Similarity
messages: Belongs to the SPT2 family.

9595:LOC101145975
gene id: 9595:LOC101145975
uniprot id: G3SEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:GNG4
gene id: 9595:GNG4
uniprot id: G3QY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:LHFPL6
gene id: 9595:LHFPL6
uniprot id: G3SAU7
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101146118
gene id: 9595:LOC101146118
uniprot id: A0A2I2Y5S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CDADC1
gene id: 9595:CDADC1
uniprot id: A0A2I2YRN3
uniprot id: G3QR52
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9595:SNTG1
gene id: 9595:SNTG1
uniprot id: A0A2I2YEY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9595:MOV10
gene id: 9595:MOV10
uniprot id: A0A2I2ZSL4
uniprot id: G3QJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9595:EHHADH
gene id: 9595:EHHADH
uniprot id: G3QXJ1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9595:UGCG
gene id: 9595:UGCG
uniprot id: G3S910
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9595:RNASET2
gene id: 9595:RNASET2
uniprot id: G3RX09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9595:PRDM12
gene id: 9595:PRDM12
uniprot id: G3S4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9595:DLGAP3
gene id: 9595:DLGAP3
uniprot id: G3RC00
names: Similarity
messages: Belongs to the SAPAP family.

9595:KCNQ5
gene id: 9595:KCNQ5
uniprot id: G3SGQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LOC101152908
gene id: 9595:LOC101152908
uniprot id: G3QU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:UBE2H
gene id: 9595:UBE2H
uniprot id: A0A2I2YHS9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:AKAP8
gene id: 9595:AKAP8
uniprot id: G3RC79
names: Similarity
messages: Belongs to the AKAP95 family.

9595:TMEM184C
gene id: 9595:TMEM184C
uniprot id: G3S4P8
names: Subcellular Location Annotation
messages: Membrane

9595:DDX5
gene id: 9595:DDX5
uniprot id: A0A2I2ZJC9
uniprot id: G3RHC7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9595:PON1
gene id: 9595:PON1
uniprot id: G3QPZ3
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9595:EDA
gene id: 9595:EDA
uniprot id: G3QSY7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:LOC101129296
gene id: 9595:LOC101129296
uniprot id: G3QHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:WDR55
gene id: 9595:WDR55
uniprot id: G3RC37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9595:RHPN1
gene id: 9595:RHPN1
uniprot id: G3RN00
names: Similarity
messages: Belongs to the RHPN family.

9595:TOM1L2
gene id: 9595:TOM1L2
uniprot id: A0A2I2Z824
uniprot id: G3QDZ4
names: Similarity
messages: Belongs to the TOM1 family.

9595:MEIS2
gene id: 9595:MEIS2
uniprot id: A0A2I2YN11
uniprot id: G3S663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9595:CHM
gene id: 9595:CHM
uniprot id: G3RQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9595:CD53
gene id: 9595:CD53
uniprot id: G3QRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:KIAA1324
gene id: 9595:KIAA1324
uniprot id: G3RKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9595:TES
gene id: 9595:TES
uniprot id: A0A2I2ZMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

9595:GIMAP1
gene id: 9595:GIMAP1
uniprot id: G3SIP9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:HIGD2B
gene id: 9595:HIGD2B
uniprot id: G3RH47
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9595:NUCB2
gene id: 9595:NUCB2
uniprot id: G3QSY6
names: Similarity
messages: Belongs to the nucleobindin family.

9595:ST6GALNAC3
gene id: 9595:ST6GALNAC3
uniprot id: G3QGI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:ADGRG5
gene id: 9595:ADGRG5
uniprot id: G3RE93
names: Subcellular Location Annotation
messages: Membrane

9595:MTR
gene id: 9595:MTR
uniprot id: G3RTZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9595:TMA7
gene id: 9595:TMA7
uniprot id: G3S1Z1
names: Similarity
messages: Belongs to the TMA7 family.

9595:EIF3K
gene id: 9595:EIF3K
uniprot id: A0A2I2ZVW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9595:FGF7
gene id: 9595:FGF7
uniprot id: G3QRL0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:BEST4
gene id: 9595:BEST4
uniprot id: G3QS90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9595:RBM5
gene id: 9595:RBM5
uniprot id: G3REZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9595:SLCO4C1
gene id: 9595:SLCO4C1
uniprot id: G3RSC6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ITGA1
gene id: 9595:ITGA1
uniprot id: G3RPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:LAMP3
gene id: 9595:LAMP3
uniprot id: G3QSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9595:IFRD1
gene id: 9595:IFRD1
uniprot id: G3QEL0
uniprot id: G3S2A4
names: Similarity
messages: Belongs to the IFRD family.

9595:OTOF
gene id: 9595:OTOF
uniprot id: G3QCR4
uniprot id: G3RZU3
names: Similarity
messages: Belongs to the ferlin family.

9595:APLP1
gene id: 9595:APLP1
uniprot id: A0A2I2Z327
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CAPN13
gene id: 9595:CAPN13
uniprot id: G3RHW3
names: Similarity
messages: Belongs to the peptidase C2 family.

9595:SSR1
gene id: 9595:SSR1
uniprot id: G3RQC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9595:NEURL2
gene id: 9595:NEURL2
uniprot id: G3RIM8
names: Subcellular Location Annotation
messages: Cytoplasm

9595:IFT43
gene id: 9595:IFT43
uniprot id: G3QGK5
names: Similarity
messages: Belongs to the IFT43 family.

9595:HTR2B
gene id: 9595:HTR2B
uniprot id: G3RUA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9595:TMEM33
gene id: 9595:TMEM33
uniprot id: G3R183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9595:KCNJ5
gene id: 9595:KCNJ5
uniprot id: G3S2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9595:LOC101129851
gene id: 9595:LOC101129851
uniprot id: G3QHN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9595:YY1
gene id: 9595:YY1
uniprot id: G3S7S5
names: Similarity
messages: Belongs to the YY transcription factor family.

9595:SERPINB7
gene id: 9595:SERPINB7
uniprot id: A0A2I2ZET6
uniprot id: G3R4Q2
names: Similarity
messages: Belongs to the serpin family.

9595:CD38
gene id: 9595:CD38
uniprot id: G3QTK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

9595:TAS2R60
gene id: 9595:TAS2R60
uniprot id: G3QLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:ERLIN1
gene id: 9595:ERLIN1
uniprot id: G3R4T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9595:CFAP52
gene id: 9595:CFAP52
uniprot id: G3RMK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9595:UBE3D
gene id: 9595:UBE3D
uniprot id: G3RKB3
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9595:SLC1A7
gene id: 9595:SLC1A7
uniprot id: A0A2I2Z0Q9
uniprot id: A0A2I2ZH63
uniprot id: G3RPG0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:WNT10A
gene id: 9595:WNT10A
uniprot id: G3QEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:CDK5RAP3
gene id: 9595:CDK5RAP3
uniprot id: G3S7B3
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9595:BAIAP3
gene id: 9595:BAIAP3
uniprot id: G3R7P0
names: Similarity
messages: Belongs to the unc-13 family.

9595:FAM13B
gene id: 9595:FAM13B
uniprot id: A0A2I2ZTU0
uniprot id: G3RWK1
names: Similarity
messages: Belongs to the FAM13 family.

9595:UGT8
gene id: 9595:UGT8
uniprot id: G3S0Z3
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9595:GNAT3
gene id: 9595:GNAT3
uniprot id: G3R3M1
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:ASB17
gene id: 9595:ASB17
uniprot id: G3QL23
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9595:SYP
gene id: 9595:SYP
uniprot id: G3QG14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9595:GFRA3
gene id: 9595:GFRA3
uniprot id: G3RMP9
names: Similarity
messages: Belongs to the GDNFR family.

9595:MB
gene id: 9595:MB
uniprot id: G3R764
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9595:DYNC2LI1
gene id: 9595:DYNC2LI1
uniprot id: G3SFZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9595:HIKESHI
gene id: 9595:HIKESHI
uniprot id: G3SJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9595:MUTYH
gene id: 9595:MUTYH
uniprot id: G3SJD1
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

9595:SPRY1
gene id: 9595:SPRY1
uniprot id: A0A2I2Y4S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9595:IGFL3
gene id: 9595:IGFL3
uniprot id: G3QS22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9595:PDGFD
gene id: 9595:PDGFD
uniprot id: G3QI67
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RDH14
gene id: 9595:RDH14
uniprot id: G3R8I8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:CDK15
gene id: 9595:CDK15
uniprot id: A0A2I2YJ08
uniprot id: G3SIA0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SDR42E1
gene id: 9595:SDR42E1
uniprot id: G3RBJ8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9595:EDEM1
gene id: 9595:EDEM1
uniprot id: G3QI15
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:SNX6
gene id: 9595:SNX6
uniprot id: A0A2I2YBM0
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9595:FGFR2
gene id: 9595:FGFR2
uniprot id: A0A2I2ZVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:CLDN4
gene id: 9595:CLDN4
uniprot id: A0A2I2ZD15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:SGK1
gene id: 9595:SGK1
uniprot id: A0A2I2YET3
uniprot id: A0A2I2YMZ6
uniprot id: G3QGL7
uniprot id: G3S3Y0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9595:ABCC8
gene id: 9595:ABCC8
uniprot id: G3RIT5
names: Subunit
messages: Interacts with KCNJ11.

9595:AURKA
gene id: 9595:AURKA
uniprot id: G3QW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9595:CCDC103
gene id: 9595:CCDC103
uniprot id: G3SKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9595:NEMP1
gene id: 9595:NEMP1
uniprot id: G3RMP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9595:PARD6A
gene id: 9595:PARD6A
uniprot id: G3QMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9595:INSL5
gene id: 9595:INSL5
uniprot id: G3S062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9595:MBOAT7
gene id: 9595:MBOAT7
uniprot id: A0A2I2YHZ5
uniprot id: G3RTU0
names: Subcellular Location Annotation
messages: Membrane

9595:NOTCH4
gene id: 9595:NOTCH4
uniprot id: G3QIT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9595:PKIB
gene id: 9595:PKIB
uniprot id: A0A2I2Z436
uniprot id: G3RFZ3
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:GPC6
gene id: 9595:GPC6
uniprot id: G3S143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9595:LOC101131885
gene id: 9595:LOC101131885
uniprot id: G3S4Z9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:SGSM2
gene id: 9595:SGSM2
uniprot id: G3QJ30
uniprot id: G3S4Y6
names: Similarity
messages: Belongs to the RUTBC family.

9595:LOC101129658
gene id: 9595:LOC101129658
uniprot id: G3QY92
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9595:FAM219A
gene id: 9595:FAM219A
uniprot id: A0A2I2YKP2
names: Similarity
messages: Belongs to the FAM219 family.

9595:CNOT10
gene id: 9595:CNOT10
uniprot id: A0A2I2YIL4
uniprot id: G3QD61
uniprot id: G3RPD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9595:MX1
gene id: 9595:MX1
uniprot id: G3QGS5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9595:CTNNB1
gene id: 9595:CTNNB1
uniprot id: A0A2I2ZNM7
uniprot id: G3QHI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9595:RELL1
gene id: 9595:RELL1
uniprot id: G3RG41
names: Similarity
messages: Belongs to the RELT family.

9595:LOC101134051
gene id: 9595:LOC101134051
uniprot id: A0A2I2ZN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101134753
gene id: 9595:LOC101134753
uniprot id: G3R122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:USP7
gene id: 9595:USP7
uniprot id: G3QRK0
names: Similarity
messages: Belongs to the peptidase C19 family.

9595:AFG3L2
gene id: 9595:AFG3L2
uniprot id: G3QLB0
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9595:ITGA5
gene id: 9595:ITGA5
uniprot id: G3QEL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:IWS1
gene id: 9595:IWS1
uniprot id: G3R4F3
names: Subcellular Location Annotation
messages: Nucleus

9595:NECAP1
gene id: 9595:NECAP1
uniprot id: G3R403
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9595:PGAP1
gene id: 9595:PGAP1
uniprot id: A0A2I2YM28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9595:C19H19orf53
gene id: 9595:C19H19orf53
uniprot id: G3RW91
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9595:TAC1
gene id: 9595:TAC1
uniprot id: A0A2I2YSA3
uniprot id: A0A2I2ZIT3
uniprot id: G3RDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9595:LCN1
gene id: 9595:LCN1
uniprot id: G3QM49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:SMAD5
gene id: 9595:SMAD5
uniprot id: G3RTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9595:HSF2
gene id: 9595:HSF2
uniprot id: A0A2I2Y5N3
uniprot id: G3SFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9595:SCD5
gene id: 9595:SCD5
uniprot id: A0A2I2YTX0
uniprot id: A0A2I2ZW12
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9595:GABARAPL1
gene id: 9595:GABARAPL1
uniprot id: G3RMN7
names: Similarity
messages: Belongs to the ATG8 family.

9595:C9H9orf78
gene id: 9595:C9H9orf78
uniprot id: G3RC13
names: Similarity
messages: Belongs to the TLS1 family.

9595:LOC101126372
gene id: 9595:LOC101126372
uniprot id: A0A2I2YM82
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:DUOX2
gene id: 9595:DUOX2
uniprot id: G3R7S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9595:KCNH4
gene id: 9595:KCNH4
uniprot id: G3RHR1
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9595:SMCO4
gene id: 9595:SMCO4
uniprot id: G3R6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

9595:FOLR2
gene id: 9595:FOLR2
uniprot id: G3R6P4
names: Similarity
messages: Belongs to the folate receptor family.

9595:TCP11L1
gene id: 9595:TCP11L1
uniprot id: G3S9C9
names: Similarity
messages: Belongs to the TCP11 family.

9595:MANEA
gene id: 9595:MANEA
uniprot id: A0A2I2ZQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:ITGA3
gene id: 9595:ITGA3
uniprot id: A0A2I2ZSG7
uniprot id: G3RCK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:VPS33B
gene id: 9595:VPS33B
uniprot id: A0A2I2ZMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9595:LOC101128201
gene id: 9595:LOC101128201
uniprot id: G3SI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FOXS1
gene id: 9595:FOXS1
uniprot id: G3RMG2
names: Subcellular Location Annotation
messages: Nucleus

9595:GRAP
gene id: 9595:GRAP
uniprot id: G3RAF5
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9595:ISM1
gene id: 9595:ISM1
uniprot id: G3QJR0
names: Similarity
messages: Belongs to the isthmin family.

9595:CCND2
gene id: 9595:CCND2
uniprot id: G3R223
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9595:TTC19
gene id: 9595:TTC19
uniprot id: G3SDJ4
names: Similarity
messages: Belongs to the TTC19 family.

9595:MAL
gene id: 9595:MAL
uniprot id: G3QTU5
names: Subcellular Location Annotation
messages: Membrane

9595:TLCD3A
gene id: 9595:TLCD3A
uniprot id: G3RHK4
names: Subcellular Location Annotation
messages: Membrane

9595:PPP1R1A
gene id: 9595:PPP1R1A
uniprot id: G3QZ87
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9595:AQP8
gene id: 9595:AQP8
uniprot id: G3R630
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:ATP5F1C
gene id: 9595:ATP5F1C
uniprot id: A0A2I2ZNG8
uniprot id: G3R2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9595:LOC101149752
gene id: 9595:LOC101149752
uniprot id: G3RXW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9595:CCT7
gene id: 9595:CCT7
uniprot id: G3QXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9595:SNX30
gene id: 9595:SNX30
uniprot id: G3QNL2
names: Similarity
messages: Belongs to the sorting nexin family.

9595:PSMD11
gene id: 9595:PSMD11
uniprot id: G3QFG6
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9595:ANP32B
gene id: 9595:ANP32B
uniprot id: G3R7K6
names: Similarity
messages: Belongs to the ANP32 family.

9595:PRKCB
gene id: 9595:PRKCB
uniprot id: G3R5W0
uniprot id: G3SFA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9595:LOC101150151
gene id: 9595:LOC101150151
uniprot id: G3RDP1
names: Similarity
messages: Belongs to the LCE family.

9595:SYT14
gene id: 9595:SYT14
uniprot id: A0A2I2YPP3
uniprot id: G3RUY8
uniprot id: G3SBG6
names: Similarity
messages: Belongs to the synaptotagmin family.

9595:ADGRF3
gene id: 9595:ADGRF3
uniprot id: A0A2I2YNL9
uniprot id: A0A2I2ZSI8
names: Subcellular Location Annotation
messages: Membrane

9595:TLR2
gene id: 9595:TLR2
uniprot id: B3Y615
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9595:S100A16
gene id: 9595:S100A16
uniprot id: G3S962
names: Similarity
messages: Belongs to the S-100 family.

9595:EED
gene id: 9595:EED
uniprot id: G3QX31
uniprot id: G3RT87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9595:CPNE3
gene id: 9595:CPNE3
uniprot id: G3RZC4
names: Similarity
messages: Belongs to the copine family.

9595:GGH
gene id: 9595:GGH
uniprot id: G3QXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9595:DRC1
gene id: 9595:DRC1
uniprot id: A0A2I2Y2J8
uniprot id: G3QCR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

9595:P2RX3
gene id: 9595:P2RX3
uniprot id: A0A2I2YYY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9595:ETS2
gene id: 9595:ETS2
uniprot id: G3RHG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9595:LEUTX
gene id: 9595:LEUTX
uniprot id: A0A2I2ZWG8
uniprot id: G3RZ19
names: Subcellular Location Annotation
messages: Nucleus

9595:IKBKE
gene id: 9595:IKBKE
uniprot id: G3RVG0
names: Subcellular Location Annotation
messages: Cytoplasm

9595:ORC4
gene id: 9595:ORC4
uniprot id: G3S8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9595:MRI1
gene id: 9595:MRI1
uniprot id: A0A2I2YEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9595:ZNF165
gene id: 9595:ZNF165
uniprot id: G3RE42
names: Subcellular Location Annotation
messages: Nucleus

9595:IRF6
gene id: 9595:IRF6
uniprot id: A0A2I2YEL4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:DRC7
gene id: 9595:DRC7
uniprot id: G3QZG8
uniprot id: G3SHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9595:GINS2
gene id: 9595:GINS2
uniprot id: G3RNK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9595:FTSJ1
gene id: 9595:FTSJ1
uniprot id: G3SK06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9595:PF4
gene id: 9595:PF4
uniprot id: G3RHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:SYVN1
gene id: 9595:SYVN1
uniprot id: G3QJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SLC7A3
gene id: 9595:SLC7A3
uniprot id: G3QFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9595:BCL2L11
gene id: 9595:BCL2L11
uniprot id: A0A2I2ZL36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
messages: Induces apoptosis and anoikis.

9595:MIXL1
gene id: 9595:MIXL1
uniprot id: G3QI85
names: Subcellular Location Annotation
messages: Nucleus

9595:CLCA1
gene id: 9595:CLCA1
uniprot id: G3R7X0
names: Similarity
messages: Belongs to the CLCR family.

9595:PAX6
gene id: 9595:PAX6
uniprot id: A0A2I2ZFV9
uniprot id: G3RQQ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:PORCN
gene id: 9595:PORCN
uniprot id: A0A2I2Y799
uniprot id: A0A2I2YZS7
names: Subcellular Location Annotation
messages: Membrane

9595:FPR3
gene id: 9595:FPR3
uniprot id: G3R0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9595:RNF170
gene id: 9595:RNF170
uniprot id: G3QQE5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CD22
gene id: 9595:CD22
uniprot id: Q9N1E4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
messages: Cell membrane
messages: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
messages: Phosphorylated on tyrosine residues by LYN.
messages: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
messages: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1 (By similarity).

9595:SEPTIN12
gene id: 9595:SEPTIN12
uniprot id: A0A2I2ZWR5
uniprot id: G3QX38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:CDH11
gene id: 9595:CDH11
uniprot id: G3QKI4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:AP2M1
gene id: 9595:AP2M1
uniprot id: G3QWW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9595:FUT8
gene id: 9595:FUT8
uniprot id: G3R0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9595:CMTR1
gene id: 9595:CMTR1
uniprot id: G3QSA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9595:SAG
gene id: 9595:SAG
uniprot id: G3R7T0
names: Similarity
messages: Belongs to the arrestin family.

9595:BMPR2
gene id: 9595:BMPR2
uniprot id: A0A2I2YY32
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9595:CFI
gene id: 9595:CFI
uniprot id: A0A2I2Y2K4
uniprot id: G3QLG4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ZNRF3
gene id: 9595:ZNRF3
uniprot id: G3SG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane
messages: Membrane

9595:MYO1H
gene id: 9595:MYO1H
uniprot id: G3RXN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:TMEM86A
gene id: 9595:TMEM86A
uniprot id: G3QW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9595:SYNGR1
gene id: 9595:SYNGR1
uniprot id: A0A2I2YTA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9595:LOC101138755
gene id: 9595:LOC101138755
uniprot id: G3RCH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CDH7
gene id: 9595:CDH7
uniprot id: G3R6F1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:MPP7
gene id: 9595:MPP7
uniprot id: G3RT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9595:PIP4P2
gene id: 9595:PIP4P2
uniprot id: G3RLV6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9595:LSM14A
gene id: 9595:LSM14A
uniprot id: G3QHB1
names: Similarity
messages: Belongs to the LSM14 family.

9595:LOC101125865
gene id: 9595:LOC101125865
uniprot id: G3SDU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SNAP23
gene id: 9595:SNAP23
uniprot id: A0A2I2ZF59
uniprot id: G3RIB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9595:UGT2B4
gene id: 9595:UGT2B4
uniprot id: G3RWI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:LAPTM4A
gene id: 9595:LAPTM4A
uniprot id: G3S021
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9595:PDIA4
gene id: 9595:PDIA4
uniprot id: G3RY30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9595:TMCO5A
gene id: 9595:TMCO5A
uniprot id: G3R7B0
uniprot id: G3SHK0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC25A44
gene id: 9595:SLC25A44
uniprot id: G3R5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:GAL3ST3
gene id: 9595:GAL3ST3
uniprot id: G3RUM1
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9595:MMP21
gene id: 9595:MMP21
uniprot id: G3R704
names: Similarity
messages: Belongs to the peptidase M10A family.

9595:CLIC2
gene id: 9595:CLIC2
uniprot id: G3S4N2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9595:HOXA10
gene id: 9595:HOXA10
uniprot id: A0A2I2YIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9595:TRAPPC3
gene id: 9595:TRAPPC3
uniprot id: G3QPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9595:IL1RAPL1
gene id: 9595:IL1RAPL1
uniprot id: G3QKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9595:FREM3
gene id: 9595:FREM3
uniprot id: G3QZ62
names: Similarity
messages: Belongs to the FRAS1 family.

9595:CHMP7
gene id: 9595:CHMP7
uniprot id: G3QJA9
names: Similarity
messages: Belongs to the SNF7 family.

9595:CDX2
gene id: 9595:CDX2
uniprot id: G3SJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9595:GRB10
gene id: 9595:GRB10
uniprot id: G3QUE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9595:PGM1
gene id: 9595:PGM1
uniprot id: G3RIU8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9595:TMEM237
gene id: 9595:TMEM237
uniprot id: G3QPW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9595:SLC16A11
gene id: 9595:SLC16A11
uniprot id: G3QG12
names: Subcellular Location Annotation
messages: Membrane

9595:AIPL1
gene id: 9595:AIPL1
uniprot id: A0A2I2Y3J4
uniprot id: A0A2I2YBW2
uniprot id: G3RD98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

9595:LPL
gene id: 9595:LPL
uniprot id: G3RHE2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9595:CCNE2
gene id: 9595:CCNE2
uniprot id: G3RG37
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9595:PIK3IP1
gene id: 9595:PIK3IP1
uniprot id: A0A2I2ZGG3
uniprot id: G3QR65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GLO1
gene id: 9595:GLO1
uniprot id: G3RX74
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9595:ADCK2
gene id: 9595:ADCK2
uniprot id: G3R9E7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9595:F5
gene id: 9595:F5
uniprot id: G3R571
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:FOLR3
gene id: 9595:FOLR3
uniprot id: G3QMX1
names: Similarity
messages: Belongs to the folate receptor family.

9595:RALYL
gene id: 9595:RALYL
uniprot id: A0A2I2ZTI4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:DPEP2
gene id: 9595:DPEP2
uniprot id: G3RA64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9595:PITX3
gene id: 9595:PITX3
uniprot id: G3RR65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9595:LPCAT2
gene id: 9595:LPCAT2
uniprot id: A0A2I2YGK6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:LOC101131314
gene id: 9595:LOC101131314
uniprot id: G3S643
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SPRR2G
gene id: 9595:SPRR2G
uniprot id: A0A2I2Z4I8
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:CDCA2
gene id: 9595:CDCA2
uniprot id: G3S128
names: Subcellular Location Annotation
messages: Nucleus

9595:SENP6
gene id: 9595:SENP6
uniprot id: A0A2I2YT14
uniprot id: A0A2I2ZYU6
names: Similarity
messages: Belongs to the peptidase C48 family.

9595:PPP1R2C
gene id: 9595:PPP1R2C
uniprot id: A0A2I2ZYY3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9595:DKK4
gene id: 9595:DKK4
uniprot id: G3RIA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9595:LYPD5
gene id: 9595:LYPD5
uniprot id: A0A2I2ZQ19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:YBEY
gene id: 9595:YBEY
uniprot id: A0A2I2YQQ5
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9595:TMEM251
gene id: 9595:TMEM251
uniprot id: G3S4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

9595:WRNIP1
gene id: 9595:WRNIP1
uniprot id: G3RVZ9
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9595:GFRA2
gene id: 9595:GFRA2
uniprot id: G3RD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9595:SMARCD2
gene id: 9595:SMARCD2
uniprot id: G3RMF2
names: Similarity
messages: Belongs to the SMARCD family.

9595:SLC18A2
gene id: 9595:SLC18A2
uniprot id: A0A2I2ZPT5
names: Subcellular Location Annotation
messages: Membrane

9595:HSDL1
gene id: 9595:HSDL1
uniprot id: G3RIW2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:FAM102B
gene id: 9595:FAM102B
uniprot id: A0A2I2ZIZ1
names: Similarity
messages: Belongs to the FAM102 family.

9595:LOC101147293
gene id: 9595:LOC101147293
uniprot id: G3RBS9
uniprot id: G3RW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9595:TNFRSF10C
gene id: 9595:TNFRSF10C
uniprot id: A0A2I2ZU78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:VGLL1
gene id: 9595:VGLL1
uniprot id: G3QUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9595:PDE1B
gene id: 9595:PDE1B
uniprot id: A0A2I2ZYH9
uniprot id: G3QZ83
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:TIGD7
gene id: 9595:TIGD7
uniprot id: G3R4K8
names: Subcellular Location Annotation
messages: Nucleus

9595:TLCD1
gene id: 9595:TLCD1
uniprot id: A0A2I2ZNX2
uniprot id: G3RKQ3
names: Subcellular Location Annotation
messages: Membrane

9595:SLC1A2
gene id: 9595:SLC1A2
uniprot id: A0A2I2Y9Z5
uniprot id: A0A2I2ZRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:SCN5A
gene id: 9595:SCN5A
uniprot id: A0A2I2YCL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:RPL5
gene id: 9595:RPL5
uniprot id: G3QJR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9595:TMPRSS7
gene id: 9595:TMPRSS7
uniprot id: G3QLY4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TAF15
gene id: 9595:TAF15
uniprot id: G3SB91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9595:ABCG1
gene id: 9595:ABCG1
uniprot id: A0A2I2ZSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:SAMD4A
gene id: 9595:SAMD4A
uniprot id: A0A2I2YXP4
uniprot id: G3QEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9595:UNC45A
gene id: 9595:UNC45A
uniprot id: G3QYT2
names: Subcellular Location Annotation
messages: perinuclear region

9595:TMEM198
gene id: 9595:TMEM198
uniprot id: G3QM05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9595:GSTP1
gene id: 9595:GSTP1
uniprot id: G3SEU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9595:GRIN2A
gene id: 9595:GRIN2A
uniprot id: G3R0C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9595:LOC101128940
gene id: 9595:LOC101128940
uniprot id: G3QJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:EMX2
gene id: 9595:EMX2
uniprot id: G3RKJ4
names: Subcellular Location Annotation
messages: Nucleus

9595:TAGLN3
gene id: 9595:TAGLN3
uniprot id: G3RJS5
names: Similarity
messages: Belongs to the calponin family.

9595:AFAP1L1
gene id: 9595:AFAP1L1
uniprot id: G3QRN1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

9595:TMEM254
gene id: 9595:TMEM254
uniprot id: G3RTF8
names: Subcellular Location Annotation
messages: Membrane

9595:FOXN2
gene id: 9595:FOXN2
uniprot id: A0A2I2YXV7
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101129522
gene id: 9595:LOC101129522
uniprot id: G3RK66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9595:UBE2R2
gene id: 9595:UBE2R2
uniprot id: G3RBW0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:DNAJB12
gene id: 9595:DNAJB12
uniprot id: G3QEH8
names: Subcellular Location Annotation
messages: Membrane

9595:KRT222
gene id: 9595:KRT222
uniprot id: G3RCY3
names: Similarity
messages: Belongs to the intermediate filament family.

9595:GPR50
gene id: 9595:GPR50
uniprot id: G3RAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ARRDC3
gene id: 9595:ARRDC3
uniprot id: G3QNT9
names: Similarity
messages: Belongs to the arrestin family.

9595:CNTNAP1
gene id: 9595:CNTNAP1
uniprot id: G3QLG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9595:CELF2
gene id: 9595:CELF2
uniprot id: G3RVT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9595:ADAM12
gene id: 9595:ADAM12
uniprot id: A0A2I2ZJF2
uniprot id: G3QEP0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TRPC4
gene id: 9595:TRPC4
uniprot id: G3QW39
names: Subcellular Location Annotation
messages: Membrane

9595:KCND2
gene id: 9595:KCND2
uniprot id: A0A2I2YDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9595:GTPBP10
gene id: 9595:GTPBP10
uniprot id: G3SKK6
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9595:CA13
gene id: 9595:CA13
uniprot id: G3QTM5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9595:DDX41
gene id: 9595:DDX41
uniprot id: G3REY5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9595:RABGGTA
gene id: 9595:RABGGTA
uniprot id: A0A2I2ZP66
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9595:LIN28A
gene id: 9595:LIN28A
uniprot id: A0A2I2ZBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9595:NSRP1
gene id: 9595:NSRP1
uniprot id: G3RTX8
names: Similarity
messages: Belongs to the NSRP1 family.

9595:CUEDC2
gene id: 9595:CUEDC2
uniprot id: G3QVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9595:SLC26A5
gene id: 9595:SLC26A5
uniprot id: A0A2I2YPH1
uniprot id: A0A2I2ZQK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LOC101137046
gene id: 9595:LOC101137046
uniprot id: G3QUU9
names: Similarity
messages: Belongs to the S-100 family.

9595:ITGAM
gene id: 9595:ITGAM
uniprot id: G3QN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:FAM167B
gene id: 9595:FAM167B
uniprot id: G3S571
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9595:DTD1
gene id: 9595:DTD1
uniprot id: G3QCX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9595:TMEM265
gene id: 9595:TMEM265
uniprot id: A0A2I2ZSA5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:TATDN2
gene id: 9595:TATDN2
uniprot id: G3R3S1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9595:SOGA3
gene id: 9595:SOGA3
uniprot id: G3QCT0
names: Similarity
messages: Belongs to the SOGA family.

9595:LOC101141279
gene id: 9595:LOC101141279
uniprot id: P30378
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

9595:LOC101126380
gene id: 9595:LOC101126380
uniprot id: G3REL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:EPGN
gene id: 9595:EPGN
uniprot id: A0A2I2Y861
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MIS18A
gene id: 9595:MIS18A
uniprot id: G3QQ71
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9595:STC2
gene id: 9595:STC2
uniprot id: G3RD02
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9595:C5H5orf30
gene id: 9595:C5H5orf30
uniprot id: A0A2I2Z2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9595:AGPAT3
gene id: 9595:AGPAT3
uniprot id: A0A2I2ZNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:HSPB1
gene id: 9595:HSPB1
uniprot id: G3QJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9595:TNFSF11
gene id: 9595:TNFSF11
uniprot id: G3R6F7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9595:LOC101148074
gene id: 9595:LOC101148074
uniprot id: G3QQ88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:RELL2
gene id: 9595:RELL2
uniprot id: G3RJT5
names: Similarity
messages: Belongs to the RELT family.

9595:GPR15
gene id: 9595:GPR15
uniprot id: G3RCT5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PKD2L2
gene id: 9595:PKD2L2
uniprot id: A0A2I2YNR7
uniprot id: G3R4D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9595:MARK3
gene id: 9595:MARK3
uniprot id: A0A2I2Z9D1
uniprot id: A0A2I2ZM54
uniprot id: G3RNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:RNASE6
gene id: 9595:RNASE6
uniprot id: G3SHS6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9595:LOC101128292
gene id: 9595:LOC101128292
uniprot id: G3QUL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101151260
gene id: 9595:LOC101151260
uniprot id: G3QJY7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:BECN1
gene id: 9595:BECN1
uniprot id: G3QGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9595:ALDH1L1
gene id: 9595:ALDH1L1
uniprot id: G3QQ24
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9595:SCNM1
gene id: 9595:SCNM1
uniprot id: G3QLF2
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9595:BLOC1S5
gene id: 9595:BLOC1S5
uniprot id: A0A2I2YA28
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9595:NLK
gene id: 9595:NLK
uniprot id: G3S5N7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9595:ATP5F1B
gene id: 9595:ATP5F1B
uniprot id: G3R7H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9595:VSX1
gene id: 9595:VSX1
uniprot id: A0A2I2ZMR4
uniprot id: A0A2I2ZXX9
uniprot id: G3QG17
names: Subcellular Location Annotation
messages: Nucleus

9595:UCMA
gene id: 9595:UCMA
uniprot id: A0A2I2YJT5
uniprot id: A0A2I2ZQM6
uniprot id: G3RE54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9595:ADORA2B
gene id: 9595:ADORA2B
uniprot id: G3QH04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9595:PWP2
gene id: 9595:PWP2
uniprot id: A0A2I2ZNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9595:ERBIN
gene id: 9595:ERBIN
uniprot id: A0A2I2YC48
uniprot id: A0A2I2YNW1
uniprot id: G3QWC1
uniprot id: G3S7K4
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9595:TRIM32
gene id: 9595:TRIM32
uniprot id: G3RQW7
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9595:DOK5
gene id: 9595:DOK5
uniprot id: G3RW59
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9595:SEZ6
gene id: 9595:SEZ6
uniprot id: G3R9H9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101143363
gene id: 9595:LOC101143363
uniprot id: G3SKW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DPH3
gene id: 9595:DPH3
uniprot id: A0A2I2YF98
uniprot id: A0A2I2ZEF9
names: Similarity
messages: Belongs to the DPH3 family.

9595:ERBB4
gene id: 9595:ERBB4
uniprot id: A0A2I2Z667
uniprot id: G3REI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9595:PHYHIPL
gene id: 9595:PHYHIPL
uniprot id: A0A2I2YUR1
uniprot id: A0A2I2ZQT4
uniprot id: G3R0L3
names: Similarity
messages: Belongs to the PHYHIP family.

9595:TRABD2B
gene id: 9595:TRABD2B
uniprot id: A0A2I2YYI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9595:SEMA6C
gene id: 9595:SEMA6C
uniprot id: G3S1I2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PIK3C2A
gene id: 9595:PIK3C2A
uniprot id: G3RRS8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:LOC101140206
gene id: 9595:LOC101140206
uniprot id: G3S1W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101149653
gene id: 9595:LOC101149653
uniprot id: G3RA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NDUFV1
gene id: 9595:NDUFV1
uniprot id: Q0MQI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN.
messages: Binds 1 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

9595:RIMBP3C
gene id: 9595:RIMBP3C
uniprot id: A0A2I2YSY1
names: Similarity
messages: Belongs to the RIMBP family.

9595:MS4A15
gene id: 9595:MS4A15
uniprot id: G3R845
names: Similarity
messages: Belongs to the MS4A family.

9595:NAPB
gene id: 9595:NAPB
uniprot id: A0A2I2Z2Q1
uniprot id: G3QZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9595:SESN3
gene id: 9595:SESN3
uniprot id: A0A2I2ZCX4
uniprot id: G3QQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9595:GPR171
gene id: 9595:GPR171
uniprot id: G3QEB1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PLD3
gene id: 9595:PLD3
uniprot id: G3R604
names: Similarity
messages: Belongs to the phospholipase D family.

9595:TMC3
gene id: 9595:TMC3
uniprot id: G3QR19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:DENND11
gene id: 9595:DENND11
uniprot id: G3S350
names: Similarity
messages: Belongs to the DENND11 family.

9595:IFIH1
gene id: 9595:IFIH1
uniprot id: G3RIJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9595:CHRNG
gene id: 9595:CHRNG
uniprot id: A0A2I2Z1M1
uniprot id: G3QI66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:GFAP
gene id: 9595:GFAP
uniprot id: G3RB64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

9595:DPP3
gene id: 9595:DPP3
uniprot id: G3RM62
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9595:GPR3
gene id: 9595:GPR3
uniprot id: A0A2I2Z3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CHAC2
gene id: 9595:CHAC2
uniprot id: A0A2I2ZG85
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9595:MYOZ2
gene id: 9595:MYOZ2
uniprot id: G3R4I6
names: Similarity
messages: Belongs to the myozenin family.

9595:B9D1
gene id: 9595:B9D1
uniprot id: G3QFK5
uniprot id: G3SJC3
names: Subcellular Location Annotation
messages: cilium basal body

9595:CAND1
gene id: 9595:CAND1
uniprot id: G3QF05
names: Similarity
messages: Belongs to the CAND family.

9595:SF3B6
gene id: 9595:SF3B6
uniprot id: A0A2I2Y6J6
names: Subcellular Location Annotation
messages: Nucleus

9595:SGCZ
gene id: 9595:SGCZ
uniprot id: G3QD31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9595:RGN
gene id: 9595:RGN
uniprot id: G3SBV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

9595:PKIG
gene id: 9595:PKIG
uniprot id: G3RN23
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:MANBAL
gene id: 9595:MANBAL
uniprot id: G3S5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9595:HS6ST2
gene id: 9595:HS6ST2
uniprot id: A0A2I2Z9A8
uniprot id: G3RE22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9595:BOLA3
gene id: 9595:BOLA3
uniprot id: A0A2I2ZZ20
names: Similarity
messages: Belongs to the BolA/IbaG family.

9595:ITIH3
gene id: 9595:ITIH3
uniprot id: G3QSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9595:LOC101131991
gene id: 9595:LOC101131991
uniprot id: G3RCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:UBAC1
gene id: 9595:UBAC1
uniprot id: G3QDQ8
names: Subcellular Location Annotation
messages: Cytoplasm

9595:FAM229B
gene id: 9595:FAM229B
uniprot id: G3RG91
names: Similarity
messages: Belongs to the FAM229 family.

9595:CAMK2N1
gene id: 9595:CAMK2N1
uniprot id: G3QUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9595:RPS8
gene id: 9595:RPS8
uniprot id: G3QS94
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9595:ERCC3
gene id: 9595:ERCC3
uniprot id: G3RGX4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9595:LOC101150976
gene id: 9595:LOC101150976
uniprot id: G3R6Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:VPS35L
gene id: 9595:VPS35L
uniprot id: G3QSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9595:B3GALNT2
gene id: 9595:B3GALNT2
uniprot id: G3RCS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:HNRNPUL1
gene id: 9595:HNRNPUL1
uniprot id: G3SCA9
names: Subcellular Location Annotation
messages: Nucleus

9595:ENTR1
gene id: 9595:ENTR1
uniprot id: A0A2I2YCA3
uniprot id: A0A2I2ZUW8
uniprot id: G3R5Q0
names: Similarity
messages: Belongs to the ENTR1 family.

9595:MAPK9
gene id: 9595:MAPK9
uniprot id: A0A2I2YL40
uniprot id: G3S624
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9595:ELOVL7
gene id: 9595:ELOVL7
uniprot id: A0A2I2YFJ1
uniprot id: G3RRZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ARG1
gene id: 9595:ARG1
uniprot id: G3RRL0
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9595:NPHS2
gene id: 9595:NPHS2
uniprot id: A0A2I2YN39
uniprot id: G3RH62
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:DRAM1
gene id: 9595:DRAM1
uniprot id: A0A2I2YWQ6
names: Subcellular Location Annotation
messages: Membrane

9595:GAST
gene id: 9595:GAST
uniprot id: G3RKF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9595:DLX6
gene id: 9595:DLX6
uniprot id: G3S8M4
names: Subcellular Location Annotation
messages: Nucleus

9595:NXF1
gene id: 9595:NXF1
uniprot id: G3RPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9595:TAP1
gene id: 9595:TAP1
uniprot id: G3R5U8
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9595:NKAIN2
gene id: 9595:NKAIN2
uniprot id: G3R2K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9595:ITGA6
gene id: 9595:ITGA6
uniprot id: G3QXU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:ILKAP
gene id: 9595:ILKAP
uniprot id: G3QCZ5
names: Similarity
messages: Belongs to the PP2C family.

9595:LOC101144095
gene id: 9595:LOC101144095
uniprot id: A0A2I2YC35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9595:ZWILCH
gene id: 9595:ZWILCH
uniprot id: A0A2I2ZUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9595:LSM6
gene id: 9595:LSM6
uniprot id: G3QG40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9595:RNF34
gene id: 9595:RNF34
uniprot id: G3SFL8
names: Subcellular Location Annotation
messages: Cell membrane

9595:MYO1B
gene id: 9595:MYO1B
uniprot id: A0A2I2Y765
uniprot id: A0A2I2YRV5
uniprot id: G3QIS4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:CXCL3
gene id: 9595:CXCL3
uniprot id: G3S3R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:HOXC5
gene id: 9595:HOXC5
uniprot id: G3QGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:ASZ1
gene id: 9595:ASZ1
uniprot id: Q2IBF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9595:MAP4
gene id: 9595:MAP4
uniprot id: A0A2I2ZBP4
uniprot id: G3QNV8
names: Subcellular Location Annotation
messages: cytoskeleton

9595:SCGB2A1
gene id: 9595:SCGB2A1
uniprot id: G3SF48
names: Subcellular Location Annotation
messages: Secreted

9595:DCC
gene id: 9595:DCC
uniprot id: G3QWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9595:CAPNS1
gene id: 9595:CAPNS1
uniprot id: G3QMA3
uniprot id: G3SB19
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

9595:LIN28B
gene id: 9595:LIN28B
uniprot id: G3RHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9595:SHC1
gene id: 9595:SHC1
uniprot id: G3RC60
names: Subcellular Location Annotation
messages: Cytoplasm

9595:REM2
gene id: 9595:REM2
uniprot id: G3RI30
names: Subcellular Location Annotation
messages: Cell membrane

9595:FAM210A
gene id: 9595:FAM210A
uniprot id: G3QK48
names: Similarity
messages: Belongs to the FAM210 family.

9595:LUM
gene id: 9595:LUM
uniprot id: G3S376
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9595:SCAMP2
gene id: 9595:SCAMP2
uniprot id: A0A2I2YV30
uniprot id: A0A2I2ZS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9595:LOC101127921
gene id: 9595:LOC101127921
uniprot id: G3QL15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101144878
gene id: 9595:LOC101144878
uniprot id: G3QKE2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:LOC101152722
gene id: 9595:LOC101152722
uniprot id: A0A2I2ZM97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9595:UBA7
gene id: 9595:UBA7
uniprot id: G3SJ75
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9595:CTNND1
gene id: 9595:CTNND1
uniprot id: A0A2I2Z7J6
uniprot id: G3RGV2
uniprot id: G3RQD5
names: Similarity
messages: Belongs to the beta-catenin family.

9595:APH1B
gene id: 9595:APH1B
uniprot id: A0A2I2ZC70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9595:HDHD3
gene id: 9595:HDHD3
uniprot id: G3QVP3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9595:ATP6V1G3
gene id: 9595:ATP6V1G3
uniprot id: G3QZQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:ETV6
gene id: 9595:ETV6
uniprot id: G3QGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:ATP13A5
gene id: 9595:ATP13A5
uniprot id: G3QVW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IGFBP6
gene id: 9595:IGFBP6
uniprot id: G3QKV6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:AP4M1
gene id: 9595:AP4M1
uniprot id: A0A2I2Z0A9
uniprot id: G3QJU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9595:FAM155B
gene id: 9595:FAM155B
uniprot id: G3S4T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9595:LOXL4
gene id: 9595:LOXL4
uniprot id: G3QQ45
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:DYNLL1
gene id: 9595:DYNLL1
uniprot id: G3RUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9595:KRT77
gene id: 9595:KRT77
uniprot id: G3SAV9
names: Similarity
messages: Belongs to the intermediate filament family.

9595:MAN2B1
gene id: 9595:MAN2B1
uniprot id: G3RC23
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:RGS3
gene id: 9595:RGS3
uniprot id: G3S4X9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:FAM3A
gene id: 9595:FAM3A
uniprot id: A0A2I2Y1L4
uniprot id: A0A2I2ZLG6
uniprot id: G3QRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:LOC109023173
gene id: 9595:LOC109023173
uniprot id: G3QF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ALG12
gene id: 9595:ALG12
uniprot id: G3QR58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:P2RY4
gene id: 9595:P2RY4
uniprot id: G3QEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ABL1
gene id: 9595:ABL1
uniprot id: G3R4W2
uniprot id: G3RSE2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:KLHL40
gene id: 9595:KLHL40
uniprot id: G3QTF3
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9595:NDUFS6
gene id: 9595:NDUFS6
uniprot id: Q0MQH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9595:LMNA
gene id: 9595:LMNA
uniprot id: G3QEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9595:ZCCHC17
gene id: 9595:ZCCHC17
uniprot id: A0A2I2ZKQ9
uniprot id: G3S673
names: Subcellular Location Annotation
messages: nucleolus

9595:EFHB
gene id: 9595:EFHB
uniprot id: G3S617
names: Subcellular Location Annotation
messages: cilium axoneme

9595:STAMBPL1
gene id: 9595:STAMBPL1
uniprot id: G3RWC2
names: Similarity
messages: Belongs to the peptidase M67C family.

9595:EIF2B1
gene id: 9595:EIF2B1
uniprot id: A0A2I2YRJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9595:ATOH7
gene id: 9595:ATOH7
uniprot id: G3RK03
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9595:NR4A1
gene id: 9595:NR4A1
uniprot id: A0A2I2YDL5
uniprot id: A0A2I2Z5G2
uniprot id: G3SE60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:TRIM45
gene id: 9595:TRIM45
uniprot id: G3SJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9595:CNDP1
gene id: 9595:CNDP1
uniprot id: A0A2I2Z7W3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9595:WIF1
gene id: 9595:WIF1
uniprot id: G3QJF3
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:XRN1
gene id: 9595:XRN1
uniprot id: A0A2I2YLX7
uniprot id: G3QYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9595:MPHOSPH8
gene id: 9595:MPHOSPH8
uniprot id: G3QSY3
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM135
gene id: 9595:TMEM135
uniprot id: A0A2I2YAS2
uniprot id: G3QJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9595:NT5DC2
gene id: 9595:NT5DC2
uniprot id: G3RIT6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9595:LYRM2
gene id: 9595:LYRM2
uniprot id: A0A2I2ZJ23
names: Similarity
messages: Belongs to the complex I LYR family.

9595:RGMB
gene id: 9595:RGMB
uniprot id: G3SBT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9595:TM2D2
gene id: 9595:TM2D2
uniprot id: A0A2I2YX34
names: Subcellular Location Annotation
messages: Membrane

9595:LXN
gene id: 9595:LXN
uniprot id: G3QKQ9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9595:GRHL1
gene id: 9595:GRHL1
uniprot id: G3QJQ4
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC25A43
gene id: 9595:SLC25A43
uniprot id: G3S648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:MGMT
gene id: 9595:MGMT
uniprot id: G3RKK1
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9595:CENPO
gene id: 9595:CENPO
uniprot id: A0A2I2YWJ9
uniprot id: A0A2I2ZC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9595:NAXE
gene id: 9595:NAXE
uniprot id: G3RUT3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9595:NT5C3B
gene id: 9595:NT5C3B
uniprot id: G3R3Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9595:RNFT1
gene id: 9595:RNFT1
uniprot id: G3R6G0
names: Subcellular Location Annotation
messages: Membrane

9595:MYOZ3
gene id: 9595:MYOZ3
uniprot id: A0A2I2ZHU7
names: Similarity
messages: Belongs to the myozenin family.

9595:MRPS23
gene id: 9595:MRPS23
uniprot id: G3RJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9595:MAGOH
gene id: 9595:MAGOH
uniprot id: G3QX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9595:PTS
gene id: 9595:PTS
uniprot id: A0A2I2YV86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9595:LOC101132889
gene id: 9595:LOC101132889
uniprot id: G3RCM8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9595:KIF19
gene id: 9595:KIF19
uniprot id: G3RLI9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:LOC101141025
gene id: 9595:LOC101141025
uniprot id: G3RCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:UBE2A
gene id: 9595:UBE2A
uniprot id: G3RGA3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:PTPN11
gene id: 9595:PTPN11
uniprot id: G3SJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9595:CASQ2
gene id: 9595:CASQ2
uniprot id: G3RLH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9595:ACER1
gene id: 9595:ACER1
uniprot id: G3R5N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9595:RPLP1
gene id: 9595:RPLP1
uniprot id: G3S7X2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9595:AVPR2
gene id: 9595:AVPR2
uniprot id: G3SIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

9595:LOC101125692
gene id: 9595:LOC101125692
uniprot id: G3RZG3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:LOC101132920
gene id: 9595:LOC101132920
uniprot id: G3RSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FAM83C
gene id: 9595:FAM83C
uniprot id: G3R8T6
names: Similarity
messages: Belongs to the FAM83 family.

9595:RHO
gene id: 9595:RHO
uniprot id: G3R589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9595:CACNA1E
gene id: 9595:CACNA1E
uniprot id: A0A2I2Y6K1
uniprot id: G3R686
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.

9595:CCDC149
gene id: 9595:CCDC149
uniprot id: A0A2I2ZYS2
uniprot id: G3R3U2
names: Similarity
messages: Belongs to the CCDC149 family.

9595:LALBA
gene id: 9595:LALBA
uniprot id: G3SBC1
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9595:CCL21
gene id: 9595:CCL21
uniprot id: G3S8M0
names: Subcellular Location Annotation
messages: Secreted

9595:ST6GALNAC1
gene id: 9595:ST6GALNAC1
uniprot id: G3QCR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:NFX1
gene id: 9595:NFX1
uniprot id: A0A2I2ZQ24
uniprot id: G3QV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9595:SLC24A4
gene id: 9595:SLC24A4
uniprot id: G3QYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:CCL20
gene id: 9595:CCL20
uniprot id: G3S3G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:LOC101150640
gene id: 9595:LOC101150640
uniprot id: A0A2I2Y4Q0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:TLX2
gene id: 9595:TLX2
uniprot id: G3QTX8
names: Subcellular Location Annotation
messages: Nucleus

9595:ZC3H12B
gene id: 9595:ZC3H12B
uniprot id: G3SK26
names: Similarity
messages: Belongs to the ZC3H12 family.

9595:TSTA3
gene id: 9595:TSTA3
uniprot id: G3QIY4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9595:SLC27A3
gene id: 9595:SLC27A3
uniprot id: G3QMP1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:ZNF280C
gene id: 9595:ZNF280C
uniprot id: G3RMJ0
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9595:CKMT2
gene id: 9595:CKMT2
uniprot id: G3QT01
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9595:ATP6V1E1
gene id: 9595:ATP6V1E1
uniprot id: G3RGC3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9595:ATP6V1G1
gene id: 9595:ATP6V1G1
uniprot id: A0A2I2Z1I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:ZNF280B
gene id: 9595:ZNF280B
uniprot id: G3QWZ1
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9595:ANAPC15
gene id: 9595:ANAPC15
uniprot id: A0A2I2Y308
uniprot id: G3R9U5
names: Similarity
messages: Belongs to the APC15 family.

9595:WDR12
gene id: 9595:WDR12
uniprot id: G3RQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9595:MZT1
gene id: 9595:MZT1
uniprot id: A0A2I2YEM2
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9595:TAS1R1
gene id: 9595:TAS1R1
uniprot id: A0A2I2YMU1
uniprot id: G3QVA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:NIPBL
gene id: 9595:NIPBL
uniprot id: G3SDF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9595:DDX55
gene id: 9595:DDX55
uniprot id: G3SB92
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:CDC123
gene id: 9595:CDC123
uniprot id: A0A2I2YZN4
uniprot id: G3RXA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9595:SNW1
gene id: 9595:SNW1
uniprot id: G3S3X9
uniprot id: G3SJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9595:MRPS21
gene id: 9595:MRPS21
uniprot id: G3S8Y8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9595:AQP9
gene id: 9595:AQP9
uniprot id: G3R8Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:HPDL
gene id: 9595:HPDL
uniprot id: G3QL76
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9595:FGFBP1
gene id: 9595:FGFBP1
uniprot id: G3RJ58
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9595:HNRNPA3
gene id: 9595:HNRNPA3
uniprot id: G3QTH6
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM129
gene id: 9595:TMEM129
uniprot id: A0A2I2YUT9
uniprot id: A0A2I2Z010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9595:SSR4
gene id: 9595:SSR4
uniprot id: A0A2I2ZTV2
uniprot id: G3RXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9595:GMPPB
gene id: 9595:GMPPB
uniprot id: A0A2I2YRI1
uniprot id: G3R4Z4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9595:PSMA4
gene id: 9595:PSMA4
uniprot id: G3QD78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:ALOX15B
gene id: 9595:ALOX15B
uniprot id: A0A2I2Y7V5
uniprot id: A0A2I2ZN04
uniprot id: G3REL4
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GALNT3
gene id: 9595:GALNT3
uniprot id: A0A2I2ZSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:GPR39
gene id: 9595:GPR39
uniprot id: G3RFA5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DEFB121
gene id: 9595:DEFB121
uniprot id: G3QKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:UBA1
gene id: 9595:UBA1
uniprot id: G3QX61
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9595:LOC101151014
gene id: 9595:LOC101151014
uniprot id: A0A2I2ZKF5
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101132006
gene id: 9595:LOC101132006
uniprot id: A0A2I2YVE2
names: Subcellular Location Annotation
messages: Nucleus

9595:CXCR1
gene id: 9595:CXCR1
uniprot id: A0A2I2YD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SULF1
gene id: 9595:SULF1
uniprot id: G3R9R9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:IARS2
gene id: 9595:IARS2
uniprot id: G3QWM6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:B3GAT1
gene id: 9595:B3GAT1
uniprot id: G3QIV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:TSR2
gene id: 9595:TSR2
uniprot id: A0A2I2YKB2
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9595:LOC101147746
gene id: 9595:LOC101147746
uniprot id: G3R9K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9595:DEFB135
gene id: 9595:DEFB135
uniprot id: G3QZ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:IFT46
gene id: 9595:IFT46
uniprot id: G3S8A9
uniprot id: G3S8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9595:CCSER1
gene id: 9595:CCSER1
uniprot id: A0A2I2YN34
uniprot id: G3RDV0
names: Similarity
messages: Belongs to the CCSER family.

9595:NLRP1
gene id: 9595:NLRP1
uniprot id: A0A2I2ZAJ2
uniprot id: G3R758
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NLRP family.
messages: Inflammasome
messages: cytosol

9595:CRHR2
gene id: 9595:CRHR2
uniprot id: A0A2I2YXL3
uniprot id: G3RYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9595:SHROOM4
gene id: 9595:SHROOM4
uniprot id: A0A2I2YGZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9595:LGALSL
gene id: 9595:LGALSL
uniprot id: G3QU51
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.

9595:CYLD
gene id: 9595:CYLD
uniprot id: G3QZF4
uniprot id: G3S7H6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9595:TXNRD2
gene id: 9595:TXNRD2
uniprot id: A0A2I2YCN3
uniprot id: A0A2I2ZNN4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9595:KIF3B
gene id: 9595:KIF3B
uniprot id: G3RAF7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:CSNK1G1
gene id: 9595:CSNK1G1
uniprot id: A0A2I2ZKT0
uniprot id: A0A2I2ZVN9
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9595:PPP1R1B
gene id: 9595:PPP1R1B
uniprot id: G3QV38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9595:SESN2
gene id: 9595:SESN2
uniprot id: G3REY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9595:SLC35B4
gene id: 9595:SLC35B4
uniprot id: G3QH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9595:VAMP5
gene id: 9595:VAMP5
uniprot id: G3QQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:BEST3
gene id: 9595:BEST3
uniprot id: A0A2I2YBH8
uniprot id: A0A2I2ZK62
uniprot id: A0A2I2ZYB6
uniprot id: G3R1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9595:LOC101151628
gene id: 9595:LOC101151628
uniprot id: G3R2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:UNC13D
gene id: 9595:UNC13D
uniprot id: G3SJT8
names: Similarity
messages: Belongs to the unc-13 family.

9595:HARS2
gene id: 9595:HARS2
uniprot id: G3RBJ9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9595:KDM4A
gene id: 9595:KDM4A
uniprot id: G3RYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9595:LOC101146696
gene id: 9595:LOC101146696
uniprot id: G3QGD7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CILP2
gene id: 9595:CILP2
uniprot id: G3QT55
names: Subcellular Location Annotation
messages: extracellular matrix

9595:SLC26A3
gene id: 9595:SLC26A3
uniprot id: G3QUI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Chloride/bicarbonate exchanger.
messages: Membrane

9595:POMK
gene id: 9595:POMK
uniprot id: G3RLH7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

9595:GJA8
gene id: 9595:GJA8
uniprot id: G3RX25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:TENT5C
gene id: 9595:TENT5C
uniprot id: A0A2I2YLA0
names: Similarity
messages: Belongs to the TENT family.

9595:LOC101147054
gene id: 9595:LOC101147054
uniprot id: G3QSH7
names: Subcellular Location Annotation
messages: Membrane

9595:SNX19
gene id: 9595:SNX19
uniprot id: G3SCC6
names: Similarity
messages: Belongs to the sorting nexin family.

9595:TMEM216
gene id: 9595:TMEM216
uniprot id: G3RZ04
names: Subcellular Location Annotation
messages: Membrane

9595:RAD50
gene id: 9595:RAD50
uniprot id: G3QFG8
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9595:HOOK2
gene id: 9595:HOOK2
uniprot id: G3QS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9595:TMTC4
gene id: 9595:TMTC4
uniprot id: G3R9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9595:SPDL1
gene id: 9595:SPDL1
uniprot id: G3QLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9595:SLC4A4
gene id: 9595:SLC4A4
uniprot id: G3R1F8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101152574
gene id: 9595:LOC101152574
uniprot id: G3RRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:BRF1
gene id: 9595:BRF1
uniprot id: G3QXB5
names: Similarity
messages: Belongs to the TFIIB family.

9595:CNTF
gene id: 9595:CNTF
uniprot id: G3S3R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9595:SIX1
gene id: 9595:SIX1
uniprot id: A1YER0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Interacts with DACH1 (By similarity). Interacts with EYA1 (By similarity). Interacts with EYA2 (By similarity). Interacts with CDH1 (By similarity). Interacts with TBX18 (By similarity). Interacts with CEBPA (By similarity). Interacts with CEBPB (By similarity). Interacts with EBF2 (By similarity).
messages: Nucleus
messages: Phosphorylated during interphase; becomes hyperphosphorylated during mitosis. Hyperphosphorylation impairs binding to promoter elements (By similarity).
messages: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (By similarity). Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (By similarity).
messages: Ubiquitinated by the anaphase promoting complex (APC), leading to its proteasomal degradation.

9595:TEX13A
gene id: 9595:TEX13A
uniprot id: G3QMH3
names: Similarity
messages: Belongs to the TEX13 family.

9595:CTSA
gene id: 9595:CTSA
uniprot id: G3RIP1
names: Similarity
messages: Belongs to the peptidase S10 family.

9595:HSPA8
gene id: 9595:HSPA8
uniprot id: G3RYM8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:FAM92A
gene id: 9595:FAM92A
uniprot id: G3QUB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9595:LOC101125919
gene id: 9595:LOC101125919
uniprot id: G3S4R9
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9595:PLPPR1
gene id: 9595:PLPPR1
uniprot id: G3RUV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9595:NPTX2
gene id: 9595:NPTX2
uniprot id: G3RFI7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:UROD
gene id: 9595:UROD
uniprot id: G3QGP9
uniprot id: G3SGL6
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9595:RABEP1
gene id: 9595:RABEP1
uniprot id: A0A2I2ZNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9595:GAPDHS
gene id: 9595:GAPDHS
uniprot id: A0A2I2ZPL6
uniprot id: G3QD23
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9595:EPB41
gene id: 9595:EPB41
uniprot id: A0A2I2Y6N1
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9595:CLIC1
gene id: 9595:CLIC1
uniprot id: G3R6T1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9595:C6H6orf58
gene id: 9595:C6H6orf58
uniprot id: G3QPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9595:USP22
gene id: 9595:USP22
uniprot id: A0A2I2YU55
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:B3GALT1
gene id: 9595:B3GALT1
uniprot id: Q7JK24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.
messages: Golgi apparatus membrane

9595:IGF2
gene id: 9595:IGF2
uniprot id: A0A2I2YBP4
uniprot id: A0A2I2YR49
uniprot id: A0A2I2ZL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9595:LRRFIP2
gene id: 9595:LRRFIP2
uniprot id: A0A2I2YZD3
uniprot id: G3QHD2
names: Similarity
messages: Belongs to the LRRFIP family.

9595:MAOA
gene id: 9595:MAOA
uniprot id: G3R0P3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:BIVM
gene id: 9595:BIVM
uniprot id: G3RDY0
names: Similarity
messages: Belongs to the BIVM family.

9595:BUD23
gene id: 9595:BUD23
uniprot id: G3QGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9595:EIF3H
gene id: 9595:EIF3H
uniprot id: G3QEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9595:XDH
gene id: 9595:XDH
uniprot id: G3R727
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9595:CDC42SE1
gene id: 9595:CDC42SE1
uniprot id: G3QYT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9595:CDC5L
gene id: 9595:CDC5L
uniprot id: A0A2I2YQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

9595:COPS2
gene id: 9595:COPS2
uniprot id: A0A2I2Z3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9595:RDH5
gene id: 9595:RDH5
uniprot id: G3QKX8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:RBP1
gene id: 9595:RBP1
uniprot id: G3R9C4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:SLCO1C1
gene id: 9595:SLCO1C1
uniprot id: A0A2I2ZK32
uniprot id: G3RFA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MOGAT1
gene id: 9595:MOGAT1
uniprot id: G3R0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9595:FAM83B
gene id: 9595:FAM83B
uniprot id: G3QIH2
names: Similarity
messages: Belongs to the FAM83 family.

9595:UFM1
gene id: 9595:UFM1
uniprot id: A0A2I2YYE6
uniprot id: G3SHJ8
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9595:NLN
gene id: 9595:NLN
uniprot id: A0A2I2ZDD9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9595:GLDC
gene id: 9595:GLDC
uniprot id: A0A2I2Y3V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9595:DNAH11
gene id: 9595:DNAH11
uniprot id: G3QQ20
names: Similarity
messages: Belongs to the dynein heavy chain family.

9595:CDS2
gene id: 9595:CDS2
uniprot id: G3R9G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9595:ETFB
gene id: 9595:ETFB
uniprot id: G3R168
uniprot id: G3SIW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9595:FAM241B
gene id: 9595:FAM241B
uniprot id: G3QIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9595:TMEM91
gene id: 9595:TMEM91
uniprot id: A0A2I2ZY29
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:STATH
gene id: 9595:STATH
uniprot id: A0A2I2YCL1
uniprot id: G3SG71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
messages: Secreted

9595:KCNE3
gene id: 9595:KCNE3
uniprot id: A0A2I2Y3G9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9595:APOL1
gene id: 9595:APOL1
uniprot id: A0A2I2ZQF1
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:CCR1
gene id: 9595:CCR1
uniprot id: A0A2I2ZT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:EGR1
gene id: 9595:EGR1
uniprot id: A0A2I2Y6K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9595:SLC26A7
gene id: 9595:SLC26A7
uniprot id: G3SD21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9595:LOC101137790
gene id: 9595:LOC101137790
uniprot id: G3R8R1
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:SERPINA4
gene id: 9595:SERPINA4
uniprot id: G3RLE0
names: Similarity
messages: Belongs to the serpin family.

9595:KYAT3
gene id: 9595:KYAT3
uniprot id: G3QNS8
names: Subunit
messages: Homodimer.

9595:NOX1
gene id: 9595:NOX1
uniprot id: A0A2I2YA68
uniprot id: A0A2I2YJ23
uniprot id: G3QVH2
names: Subcellular Location Annotation
messages: Membrane

9595:CDH24
gene id: 9595:CDH24
uniprot id: A0A2I2Z4R1
uniprot id: G3QWS7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:VIPR1
gene id: 9595:VIPR1
uniprot id: A0A2I2Z2U4
uniprot id: G3QNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9595:MSTN
gene id: 9595:MSTN
uniprot id: A1C2V5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9595:SLC30A5
gene id: 9595:SLC30A5
uniprot id: G3RGM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9595:LOC101147097
gene id: 9595:LOC101147097
uniprot id: G3QKQ7
names: Similarity
messages: Belongs to the HPF1 family.

9595:ECHDC2
gene id: 9595:ECHDC2
uniprot id: A0A2I2Z3F8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:ABCB11
gene id: 9595:ABCB11
uniprot id: A0A2I2Z8S9
names: Subcellular Location Annotation
messages: Endosome

9595:VNN2
gene id: 9595:VNN2
uniprot id: G3R492
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:CCL3
gene id: 9595:CCL3
uniprot id: G3RWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:GSK3A
gene id: 9595:GSK3A
uniprot id: G3QPQ5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9595:APOLD1
gene id: 9595:APOLD1
uniprot id: A0A2I2YUU2
uniprot id: A0A2I2ZTP6
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:RGMA
gene id: 9595:RGMA
uniprot id: G3SH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9595:LOC101131259
gene id: 9595:LOC101131259
uniprot id: G3S6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:CBX5
gene id: 9595:CBX5
uniprot id: G3QCU2
names: Subcellular Location Annotation
messages: Nucleus

9595:CTC1
gene id: 9595:CTC1
uniprot id: G3QK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9595:TAF1
gene id: 9595:TAF1
uniprot id: A0A2I2ZUH4
uniprot id: G3RI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9595:ADK
gene id: 9595:ADK
uniprot id: A0A2I2YPI6
uniprot id: A0A2I2Z3K2
uniprot id: G3QRM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9595:RSBN1L
gene id: 9595:RSBN1L
uniprot id: G3QVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9595:SLC9A4
gene id: 9595:SLC9A4
uniprot id: G3RF66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9595:LOC101147326
gene id: 9595:LOC101147326
uniprot id: G3RL21
names: Similarity
messages: Belongs to the TACO1 family.

9595:LRWD1
gene id: 9595:LRWD1
uniprot id: A0A2I2YVC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9595:JPT2
gene id: 9595:JPT2
uniprot id: G3QTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9595:HIBADH
gene id: 9595:HIBADH
uniprot id: G3RBS7
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9595:MCTP1
gene id: 9595:MCTP1
uniprot id: A0A2I2Z7K2
names: Subcellular Location Annotation
messages: Membrane

9595:RBBP5
gene id: 9595:RBBP5
uniprot id: G3RFR6
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM229B
gene id: 9595:TMEM229B
uniprot id: A0A2I2YX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9595:LOC101142455
gene id: 9595:LOC101142455
uniprot id: G3QT15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9595:NUP85
gene id: 9595:NUP85
uniprot id: G3QUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9595:ADAMTS20
gene id: 9595:ADAMTS20
uniprot id: G3QJC2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:NDUFS3
gene id: 9595:NDUFS3
uniprot id: Q0MQG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). Interacts with NDUFAF3 (By similarity). Interacts with RAB5IF (By similarity). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9595:REXO2
gene id: 9595:REXO2
uniprot id: A0A2I2YJB0
uniprot id: G3S0H2
names: Similarity
messages: Belongs to the oligoribonuclease family.

9595:SLC25A46
gene id: 9595:SLC25A46
uniprot id: A0A2I2ZSH1
uniprot id: G3RWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:CSTF2
gene id: 9595:CSTF2
uniprot id: A0A2I2ZTJ9
uniprot id: G3RRQ9
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM225
gene id: 9595:TMEM225
uniprot id: G3RK89
names: Subcellular Location Annotation
messages: Membrane

9595:SLC12A4
gene id: 9595:SLC12A4
uniprot id: A0A2I2YNR3
uniprot id: A0A2I2ZJH0
uniprot id: A0A2I2ZQL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:LIMD1
gene id: 9595:LIMD1
uniprot id: G3QJW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

9595:CXCL1
gene id: 9595:CXCL1
uniprot id: G3QLE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:TMEM256
gene id: 9595:TMEM256
uniprot id: G3QD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9595:CPNE6
gene id: 9595:CPNE6
uniprot id: A0A2I2YT19
names: Similarity
messages: Belongs to the copine family.

9595:LOC101123691
gene id: 9595:LOC101123691
uniprot id: G3R4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRPV5
gene id: 9595:TRPV5
uniprot id: G3RIU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:TSPAN8
gene id: 9595:TSPAN8
uniprot id: G3RKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:LOC101129483
gene id: 9595:LOC101129483
uniprot id: A0A2I2ZNI8
names: Subcellular Location Annotation
messages: Membrane

9595:DLX2
gene id: 9595:DLX2
uniprot id: G3QRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:LOC101126416
gene id: 9595:LOC101126416
uniprot id: G3SCM0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:GNS
gene id: 9595:GNS
uniprot id: G3RH59
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:FMO3
gene id: 9595:FMO3
uniprot id: G3RKD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9595:C1H1orf43
gene id: 9595:C1H1orf43
uniprot id: A0A2I2YQW7
uniprot id: A0A2I2ZYT0
uniprot id: G3S4N8
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9595:TUBB6
gene id: 9595:TUBB6
uniprot id: A0A2I2YTU3
uniprot id: G3QLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:CCL13
gene id: 9595:CCL13
uniprot id: G3QK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:CAPN6
gene id: 9595:CAPN6
uniprot id: G3QXW3
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TAFA4
gene id: 9595:TAFA4
uniprot id: G3R5L3
names: Similarity
messages: Belongs to the TAFA family.

9595:PYM1
gene id: 9595:PYM1
uniprot id: A0A2I2YZ99
uniprot id: A0A2I2ZTF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9595:MMRN1
gene id: 9595:MMRN1
uniprot id: G3QX85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PRKAB2
gene id: 9595:PRKAB2
uniprot id: G3SCS5
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9595:LIAS
gene id: 9595:LIAS
uniprot id: A0A2I2YM44
uniprot id: G3SER2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9595:CHST5
gene id: 9595:CHST5
uniprot id: A0A2I2YA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:HNF4G
gene id: 9595:HNF4G
uniprot id: G3QZI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:SLC1A4
gene id: 9595:SLC1A4
uniprot id: G3R6H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:NOL11
gene id: 9595:NOL11
uniprot id: G3RPK8
names: Subcellular Location Annotation
messages: nucleolus

9595:IL15
gene id: 9595:IL15
uniprot id: A0A2I2Z0S9
uniprot id: G3R6N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9595:LVRN
gene id: 9595:LVRN
uniprot id: G3QWK5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:INTS10
gene id: 9595:INTS10
uniprot id: G3RVH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9595:TMED4
gene id: 9595:TMED4
uniprot id: G3R8N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LDHD
gene id: 9595:LDHD
uniprot id: G3R505
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9595:HSPA14
gene id: 9595:HSPA14
uniprot id: A0A2I2ZFK4
uniprot id: G3QPS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9595:N4BP3
gene id: 9595:N4BP3
uniprot id: G3QCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9595:PABPC4
gene id: 9595:PABPC4
uniprot id: G3RT08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9595:POP5
gene id: 9595:POP5
uniprot id: G3RCE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9595:RSRP1
gene id: 9595:RSRP1
uniprot id: G3QRH7
names: Similarity
messages: Belongs to the RSRP family.

9595:CCKAR
gene id: 9595:CCKAR
uniprot id: G3RGQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9595:SEMA6A
gene id: 9595:SEMA6A
uniprot id: G3RRP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FMOD
gene id: 9595:FMOD
uniprot id: G3R879
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9595:CPLX3
gene id: 9595:CPLX3
uniprot id: G3QJP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:DRGX
gene id: 9595:DRGX
uniprot id: G3QYQ5
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM133A
gene id: 9595:FAM133A
uniprot id: A0A2I2YMD1
names: Similarity
messages: Belongs to the FAM133 family.

9595:DIPK2B
gene id: 9595:DIPK2B
uniprot id: A0A2I2ZK45
uniprot id: G3RKI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9595:CHMP2B
gene id: 9595:CHMP2B
uniprot id: G3SJW8
names: Similarity
messages: Belongs to the SNF7 family.

9595:KIF13B
gene id: 9595:KIF13B
uniprot id: G3RMN3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:ENKD1
gene id: 9595:ENKD1
uniprot id: G3QMS2
names: Subcellular Location Annotation
messages: cilium axoneme

9595:EVX1
gene id: 9595:EVX1
uniprot id: G3RR05
names: Subcellular Location Annotation
messages: Nucleus

9595:PSMA1
gene id: 9595:PSMA1
uniprot id: G3QGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:ARHGEF7
gene id: 9595:ARHGEF7
uniprot id: A0A2I2ZG12
names: Subcellular Location Annotation
messages: lamellipodium

9595:SLC6A5
gene id: 9595:SLC6A5
uniprot id: G3QKV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:GPX7
gene id: 9595:GPX7
uniprot id: G3RFD9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9595:NUTM1
gene id: 9595:NUTM1
uniprot id: G3QXF0
uniprot id: G3RUC8
names: Similarity
messages: Belongs to the NUT family.

9595:VIL1
gene id: 9595:VIL1
uniprot id: G3REI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9595:EXOG
gene id: 9595:EXOG
uniprot id: A0A2I2YI25
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9595:PLAGL2
gene id: 9595:PLAGL2
uniprot id: A0A2I2Y8A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9595:FBL
gene id: 9595:FBL
uniprot id: G3RZC3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9595:KCNK7
gene id: 9595:KCNK7
uniprot id: G3R7Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:NDUFB1
gene id: 9595:NDUFB1
uniprot id: G3RNN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:CHST2
gene id: 9595:CHST2
uniprot id: G3R5W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:CEP19
gene id: 9595:CEP19
uniprot id: G3S8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9595:CCDC25
gene id: 9595:CCDC25
uniprot id: G3R2K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9595:PROK2
gene id: 9595:PROK2
uniprot id: A0A2I2ZGH7
uniprot id: G3RZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9595:CPLANE2
gene id: 9595:CPLANE2
uniprot id: G3QNW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9595:PRM1
gene id: 9595:PRM1
uniprot id: P35303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

9595:FAP
gene id: 9595:FAP
uniprot id: A0A2I2ZHP9
uniprot id: G3RGI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9595:POLR2L
gene id: 9595:POLR2L
uniprot id: G3R5H2
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9595:PLA2G4E
gene id: 9595:PLA2G4E
uniprot id: G3R844
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9595:CHRNA9
gene id: 9595:CHRNA9
uniprot id: G3RK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:ETFDH
gene id: 9595:ETFDH
uniprot id: G3S2H8
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9595:CD63
gene id: 9595:CD63
uniprot id: G3QKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9595:ZFYVE16
gene id: 9595:ZFYVE16
uniprot id: G3S6W8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9595:SYNE1
gene id: 9595:SYNE1
uniprot id: G3RG48
names: Similarity
messages: Belongs to the nesprin family.

9595:OAS2
gene id: 9595:OAS2
uniprot id: G3QYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9595:PMS1
gene id: 9595:PMS1
uniprot id: A0A2I2Y7B3
uniprot id: A0A2I2ZTS4
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9595:ALKBH1
gene id: 9595:ALKBH1
uniprot id: G3R638
names: Similarity
messages: Belongs to the alkB family.

9595:PCOLCE
gene id: 9595:PCOLCE
uniprot id: G3R5A8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LOC101133653
gene id: 9595:LOC101133653
uniprot id: G3S3T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC2A4
gene id: 9595:SLC2A4
uniprot id: G3QWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9595:HSPA4L
gene id: 9595:HSPA4L
uniprot id: G3RSH5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:EXO5
gene id: 9595:EXO5
uniprot id: G3S9X2
names: Similarity
messages: Belongs to the EXO5 family.

9595:FAM118A
gene id: 9595:FAM118A
uniprot id: G3QH63
names: Similarity
messages: Belongs to the FAM118 family.

9595:LRP8
gene id: 9595:LRP8
uniprot id: A0A2I2YGF2
uniprot id: A0A2I2ZJL4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SMR3B
gene id: 9595:SMR3B
uniprot id: G3R0L7
names: Subcellular Location Annotation
messages: Secreted

9595:TRPM3
gene id: 9595:TRPM3
uniprot id: A0A2I2Y5U9
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101127832
gene id: 9595:LOC101127832
uniprot id: G3R1D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:UFD1
gene id: 9595:UFD1
uniprot id: G3QNC2
names: Similarity
messages: Belongs to the UFD1 family.

9595:ZNF445
gene id: 9595:ZNF445
uniprot id: A0A2I2ZW14
names: Subcellular Location Annotation
messages: Nucleus

9595:BCLAF1
gene id: 9595:BCLAF1
uniprot id: G3QHH1
uniprot id: G3SDE6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9595:USP11
gene id: 9595:USP11
uniprot id: A0A2I2YAR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9595:LOC101147918
gene id: 9595:LOC101147918
uniprot id: G3QXZ8
names: Similarity
messages: Belongs to the serpin family.

9595:TWISTNB
gene id: 9595:TWISTNB
uniprot id: G3RU18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: nucleolus

9595:PIF1
gene id: 9595:PIF1
uniprot id: G3S8K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9595:DDI2
gene id: 9595:DDI2
uniprot id: G3SEM0
names: Similarity
messages: Belongs to the DDI1 family.

9595:GNG3
gene id: 9595:GNG3
uniprot id: G3QL06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:CEPT1
gene id: 9595:CEPT1
uniprot id: G3R2A9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9595:ENTPD6
gene id: 9595:ENTPD6
uniprot id: G3RG09
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:RAB3C
gene id: 9595:RAB3C
uniprot id: G3RCG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9595:ABRAXAS2
gene id: 9595:ABRAXAS2
uniprot id: G3RDS2
names: Subcellular Location Annotation
messages: Nucleus

9595:WDR91
gene id: 9595:WDR91
uniprot id: G3QF22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:FABP7
gene id: 9595:FABP7
uniprot id: A0A2I2YNI9
uniprot id: G3S7I0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:STH
gene id: 9595:STH
uniprot id: Q5YCU7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PRDX6.
messages: Nucleus

9595:LOC101134111
gene id: 9595:LOC101134111
uniprot id: G3R9R6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:NR0B1
gene id: 9595:NR0B1
uniprot id: G3QIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9595:SORCS1
gene id: 9595:SORCS1
uniprot id: A0A2I2Z2C3
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9595:LOC101149517
gene id: 9595:LOC101149517
uniprot id: A0A2I2Z5Y2
uniprot id: G3R4P4
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9595:SLC25A1
gene id: 9595:SLC25A1
uniprot id: G3QTN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:GSK3B
gene id: 9595:GSK3B
uniprot id: A0A2I2Y1S1
uniprot id: A0A2I2Y5E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:SPOPL
gene id: 9595:SPOPL
uniprot id: G3SJ46
names: Similarity
messages: Belongs to the Tdpoz family.

9595:LOC101129736
gene id: 9595:LOC101129736
uniprot id: G3S5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SNRPE
gene id: 9595:SNRPE
uniprot id: A0A2I2ZKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9595:CWF19L2
gene id: 9595:CWF19L2
uniprot id: G3QCV0
names: Similarity
messages: Belongs to the CWF19 family.

9595:TMEM214
gene id: 9595:TMEM214
uniprot id: G3RL76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:AP2B1
gene id: 9595:AP2B1
uniprot id: G3RHU1
uniprot id: G3S3T5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9595:ANXA5
gene id: 9595:ANXA5
uniprot id: G3RKK8
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9595:ALDOB
gene id: 9595:ALDOB
uniprot id: A0A2I2ZJH2
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9595:VPS13A
gene id: 9595:VPS13A
uniprot id: A0A2I2Z1I4
uniprot id: A0A2I2ZIU4
uniprot id: A0A2I2ZY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9595:ARL6IP5
gene id: 9595:ARL6IP5
uniprot id: G3QFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9595:GPX8
gene id: 9595:GPX8
uniprot id: A0A2I2Y2C7
uniprot id: G3RA98
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9595:QRFP
gene id: 9595:QRFP
uniprot id: G3R4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9595:QTRT2
gene id: 9595:QTRT2
uniprot id: A0A2I2YG64
uniprot id: G3S8V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9595:NRG1
gene id: 9595:NRG1
uniprot id: A0A2I2YBR6
uniprot id: A0A2I2ZW64
uniprot id: G3S8R5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9595:CLTCL1
gene id: 9595:CLTCL1
uniprot id: G3S0H9
uniprot id: G3S7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9595:CHGA
gene id: 9595:CHGA
uniprot id: G3SJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9595:IGFBP3
gene id: 9595:IGFBP3
uniprot id: G3QGS3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LOC101148492
gene id: 9595:LOC101148492
uniprot id: G3SBD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GNMT
gene id: 9595:GNMT
uniprot id: G3RCK3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9595:FAM83G
gene id: 9595:FAM83G
uniprot id: G3RAE3
names: Similarity
messages: Belongs to the FAM83 family.

9595:PMPCA
gene id: 9595:PMPCA
uniprot id: G3R5R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9595:ACKR2
gene id: 9595:ACKR2
uniprot id: G3RXD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9595:HSP90AB1
gene id: 9595:HSP90AB1
uniprot id: G3R0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9595:PDK3
gene id: 9595:PDK3
uniprot id: G3SE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:UCHL1
gene id: 9595:UCHL1
uniprot id: G3R0C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:HBEGF
gene id: 9595:HBEGF
uniprot id: G3QDG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GLRB
gene id: 9595:GLRB
uniprot id: G3S3Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:ACAT2
gene id: 9595:ACAT2
uniprot id: G3RDU7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:AMBN
gene id: 9595:AMBN
uniprot id: G3RCU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9595:APOA5
gene id: 9595:APOA5
uniprot id: G3QEG1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9595:GABRA6
gene id: 9595:GABRA6
uniprot id: G3QET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:BTG4
gene id: 9595:BTG4
uniprot id: A0A2I2YKN2
names: Similarity
messages: Belongs to the BTG family.

9595:DCTN1
gene id: 9595:DCTN1
uniprot id: A0A2I2YZT7
uniprot id: G3RAK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9595:CNR2
gene id: 9595:CNR2
uniprot id: G3SC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:KCNQ1
gene id: 9595:KCNQ1
uniprot id: A0A2I2YY26
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9595:FBLN7
gene id: 9595:FBLN7
uniprot id: A0A2I2ZS34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CDPF1
gene id: 9595:CDPF1
uniprot id: G3SJ38
names: Similarity
messages: Belongs to the CDPF1 family.

9595:DPH5
gene id: 9595:DPH5
uniprot id: G3RMY5
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9595:NETO2
gene id: 9595:NETO2
uniprot id: G3SFF0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CACNA1S
gene id: 9595:CACNA1S
uniprot id: A0A2I2Y756
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9595:GOLPH3L
gene id: 9595:GOLPH3L
uniprot id: G3QEZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9595:LOC101136919
gene id: 9595:LOC101136919
uniprot id: G3R4N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101127726
gene id: 9595:LOC101127726
uniprot id: G3S0T1
names: Subunit
messages: Interacts with hair keratins.

9595:NLRP8
gene id: 9595:NLRP8
uniprot id: G3QK83
names: Similarity
messages: Belongs to the NLRP family.

9595:GALP
gene id: 9595:GALP
uniprot id: G3RDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
messages: Secreted

9595:LOC109024886
gene id: 9595:LOC109024886
uniprot id: A0A2I2YHC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PAPOLG
gene id: 9595:PAPOLG
uniprot id: G3QTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9595:TMEM45B
gene id: 9595:TMEM45B
uniprot id: G3S4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9595:RAG2
gene id: 9595:RAG2
uniprot id: G3SIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9595:REXO4
gene id: 9595:REXO4
uniprot id: G3RF01
names: Similarity
messages: Belongs to the REXO4 family.

9595:C15H15orf65
gene id: 9595:C15H15orf65
uniprot id: A0A2I2YXM8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9595:HGD
gene id: 9595:HGD
uniprot id: G3R0Y8
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9595:ABT1
gene id: 9595:ABT1
uniprot id: G3RRH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9595:ZP1
gene id: 9595:ZP1
uniprot id: G3RCV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9595:PDE7B
gene id: 9595:PDE7B
uniprot id: G3REW8
uniprot id: G3S185
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:FAM155A
gene id: 9595:FAM155A
uniprot id: G3RJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9595:SLC13A1
gene id: 9595:SLC13A1
uniprot id: G3QU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9595:LOC109024885
gene id: 9595:LOC109024885
uniprot id: G3SCC9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CORO6
gene id: 9595:CORO6
uniprot id: G3QE81
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:ATP1A3
gene id: 9595:ATP1A3
uniprot id: G3QT34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9595:KRT72
gene id: 9595:KRT72
uniprot id: G3QKU9
uniprot id: G3S9Q8
names: Similarity
messages: Belongs to the intermediate filament family.

9595:SLC31A1
gene id: 9595:SLC31A1
uniprot id: A0A2I2ZNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9595:RAB9B
gene id: 9595:RAB9B
uniprot id: G3R246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9595:CPNE9
gene id: 9595:CPNE9
uniprot id: G3REA9
names: Similarity
messages: Belongs to the copine family.

9595:VPS11
gene id: 9595:VPS11
uniprot id: G3S6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9595:PGLYRP3
gene id: 9595:PGLYRP3
uniprot id: G3QEY4
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9595:BFSP1
gene id: 9595:BFSP1
uniprot id: A0A2I2YB46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9595:UFL1
gene id: 9595:UFL1
uniprot id: G3RD68
names: Similarity
messages: Belongs to the UFL1 family.

9595:MYO16
gene id: 9595:MYO16
uniprot id: G3RLK0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:B3GNT9
gene id: 9595:B3GNT9
uniprot id: A0A2I2ZUA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:SPA17
gene id: 9595:SPA17
uniprot id: G3QMF2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9595:TGM2
gene id: 9595:TGM2
uniprot id: G3RCE0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:SCARB1
gene id: 9595:SCARB1
uniprot id: A0A2I2ZGV1
uniprot id: G3QUG5
names: Similarity
messages: Belongs to the CD36 family.

9595:EIF4G1
gene id: 9595:EIF4G1
uniprot id: G3RDI1
uniprot id: G3S8H8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9595:BTK
gene id: 9595:BTK
uniprot id: G3SKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9595:MAN1A2
gene id: 9595:MAN1A2
uniprot id: G3REE6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:PI4K2B
gene id: 9595:PI4K2B
uniprot id: G3RDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9595:CALU
gene id: 9595:CALU
uniprot id: A0A2I2ZSU5
uniprot id: G3QSQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9595:EBNA1BP2
gene id: 9595:EBNA1BP2
uniprot id: G3R052
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9595:CHURC1
gene id: 9595:CHURC1
uniprot id: A0A2I2YS44
uniprot id: A0A2I2Z3V6
names: Similarity
messages: Belongs to the Churchill family.

9595:SLA
gene id: 9595:SLA
uniprot id: G3RD32
names: Subcellular Location Annotation
messages: Cytoplasm

9595:AFF1
gene id: 9595:AFF1
uniprot id: G3RNV3
names: Similarity
messages: Belongs to the AF4 family.

9595:C16H16orf87
gene id: 9595:C16H16orf87
uniprot id: A0A2I2Y569
uniprot id: A0A2I2ZFU9
names: Similarity
messages: Belongs to the UPF0547 family.

9595:HPSE2
gene id: 9595:HPSE2
uniprot id: A0A2I2Y7W1
uniprot id: A0A2I2ZBM5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9595:PPDPFL
gene id: 9595:PPDPFL
uniprot id: G3QT11
names: Similarity
messages: Belongs to the PPDPF family.

9595:LOC101133995
gene id: 9595:LOC101133995
uniprot id: G3RX38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9595:CPNE5
gene id: 9595:CPNE5
uniprot id: G3QSK9
names: Similarity
messages: Belongs to the copine family.

9595:SLC17A1
gene id: 9595:SLC17A1
uniprot id: G3QW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9595:RCE1
gene id: 9595:RCE1
uniprot id: G3REW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CNPY2
gene id: 9595:CNPY2
uniprot id: G3R152
names: Similarity
messages: Belongs to the canopy family.

9595:PATL2
gene id: 9595:PATL2
uniprot id: G3SF59
names: Similarity
messages: Belongs to the PAT1 family.

9595:EXTL1
gene id: 9595:EXTL1
uniprot id: G3RJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:PIM1
gene id: 9595:PIM1
uniprot id: G3S2M1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9595:PSMB9
gene id: 9595:PSMB9
uniprot id: G3R5V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:FAM189B
gene id: 9595:FAM189B
uniprot id: A0A2I2Z2I4
uniprot id: G3R1X5
names: Similarity
messages: Belongs to the ENTREP family.

9595:STOML1
gene id: 9595:STOML1
uniprot id: G3RFS7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:CDK5RAP2
gene id: 9595:CDK5RAP2
uniprot id: A0A2I2Y5L0
uniprot id: G3QD67
names: Subcellular Location Annotation
messages: centrosome

9595:IMPG1
gene id: 9595:IMPG1
uniprot id: A0A2I2YE69
uniprot id: G3S150
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9595:LOC101137794
gene id: 9595:LOC101137794
uniprot id: G3QKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MED28
gene id: 9595:MED28
uniprot id: G3QFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9595:C8B
gene id: 9595:C8B
uniprot id: A0A2I2ZW46
uniprot id: G3QZQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LOC101126229
gene id: 9595:LOC101126229
uniprot id: G3QPJ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:PRPS2
gene id: 9595:PRPS2
uniprot id: G3QZ28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9595:ATP5IF1
gene id: 9595:ATP5IF1
uniprot id: G3QEV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9595:HSPB9
gene id: 9595:HSPB9
uniprot id: G3QRU3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9595:TIMM22
gene id: 9595:TIMM22
uniprot id: A0A2I2Y419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9595:KCNA6
gene id: 9595:KCNA6
uniprot id: A0A2I2YQ40
names: Subcellular Location Annotation
messages: Membrane

9595:MRC2
gene id: 9595:MRC2
uniprot id: G3QHG6
names: Subcellular Location Annotation
messages: Membrane

9595:DDC
gene id: 9595:DDC
uniprot id: A0A2I2YGG3
uniprot id: G3QTY2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:LOC101152080
gene id: 9595:LOC101152080
uniprot id: A0A2I2ZQS3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:FAM76B
gene id: 9595:FAM76B
uniprot id: G3RC57
names: Similarity
messages: Belongs to the FAM76 family.

9595:GPR17
gene id: 9595:GPR17
uniprot id: G3QPZ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:EIF6
gene id: 9595:EIF6
uniprot id: G3R8T1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9595:RPF1
gene id: 9595:RPF1
uniprot id: G3RIH1
names: Subcellular Location Annotation
messages: nucleolus

9595:TCEAL1
gene id: 9595:TCEAL1
uniprot id: A1YEW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).
messages: Nucleus

9595:GPR83
gene id: 9595:GPR83
uniprot id: G3QXI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:NNT
gene id: 9595:NNT
uniprot id: G3QRV0
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9595:ORMDL2
gene id: 9595:ORMDL2
uniprot id: G3RBN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9595:DLAT
gene id: 9595:DLAT
uniprot id: G3QJ95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9595:LOC101141821
gene id: 9595:LOC101141821
uniprot id: G3QHA0
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9595:KCNK4
gene id: 9595:KCNK4
uniprot id: G3RRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:SLC25A4
gene id: 9595:SLC25A4
uniprot id: A0A2I2YVC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9595:PDE6D
gene id: 9595:PDE6D
uniprot id: G3RCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9595:PDE4B
gene id: 9595:PDE4B
uniprot id: A0A2I2YS69
uniprot id: G3S4M8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:RIC8B
gene id: 9595:RIC8B
uniprot id: A0A2I2YTZ8
uniprot id: A0A2I2YYP3
uniprot id: G3RG53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9595:TNFSF13
gene id: 9595:TNFSF13
uniprot id: G3R7B3
uniprot id: G3S155
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:LOC101151143
gene id: 9595:LOC101151143
uniprot id: G3R144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MRPL50
gene id: 9595:MRPL50
uniprot id: G3SHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9595:PSAPL1
gene id: 9595:PSAPL1
uniprot id: G3QK07
names: Function
names: Subcellular Location Annotation
messages: May activate the lysosomal degradation of sphingolipids.
messages: Secreted

9595:PFN2
gene id: 9595:PFN2
uniprot id: G3QW12
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

9595:OXA1L
gene id: 9595:OXA1L
uniprot id: G3SFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9595:SYNDIG1L
gene id: 9595:SYNDIG1L
uniprot id: G3R0A6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:NCAM1
gene id: 9595:NCAM1
uniprot id: A0A2I2YTZ4
uniprot id: G3RBD2
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

9595:DCLRE1A
gene id: 9595:DCLRE1A
uniprot id: G3SF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9595:ST3GAL4
gene id: 9595:ST3GAL4
uniprot id: G3SDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:FUBP1
gene id: 9595:FUBP1
uniprot id: A0A2I2Y888
names: Subcellular Location Annotation
messages: Nucleus

9595:LRRC8C
gene id: 9595:LRRC8C
uniprot id: G3SFV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:SENP1
gene id: 9595:SENP1
uniprot id: G3SH09
names: Similarity
messages: Belongs to the peptidase C48 family.

9595:LOC101150369
gene id: 9595:LOC101150369
uniprot id: G3SKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9595:LOC101127179
gene id: 9595:LOC101127179
uniprot id: G3RPS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RRAGC
gene id: 9595:RRAGC
uniprot id: A0A2I2ZGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:MRPS26
gene id: 9595:MRPS26
uniprot id: G3QQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9595:PIH1D3
gene id: 9595:PIH1D3
uniprot id: G3R369
names: Similarity
messages: Belongs to the PIH1 family.

9595:LOC101130985
gene id: 9595:LOC101130985
uniprot id: G3QXG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CAMSAP2
gene id: 9595:CAMSAP2
uniprot id: A0A2I2Y9P0
uniprot id: G3R5L5
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9595:GPR156
gene id: 9595:GPR156
uniprot id: A0A2I2Y5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:TDRD9
gene id: 9595:TDRD9
uniprot id: G3QEV0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

9595:SYNE3
gene id: 9595:SYNE3
uniprot id: A0A2I2YP70
names: Similarity
messages: Belongs to the nesprin family.

9595:LOC101145923
gene id: 9595:LOC101145923
uniprot id: G3R4P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HMBS
gene id: 9595:HMBS
uniprot id: G3QYE8
names: Similarity
messages: Belongs to the HMBS family.

9595:PEX13
gene id: 9595:PEX13
uniprot id: A0A2I2Z1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

9595:OSGEPL1
gene id: 9595:OSGEPL1
uniprot id: G3SCJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9595:GATA6
gene id: 9595:GATA6
uniprot id: G3RZ55
names: Subcellular Location Annotation
messages: Nucleus

9595:NUDT17
gene id: 9595:NUDT17
uniprot id: G3QWG2
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9595:OTOG
gene id: 9595:OTOG
uniprot id: A0A2I2YYL9
uniprot id: G3RIY5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RSBN1
gene id: 9595:RSBN1
uniprot id: G3QMN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9595:PODXL
gene id: 9595:PODXL
uniprot id: A0A2I2ZUH8
uniprot id: G3QEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9595:SCRIB
gene id: 9595:SCRIB
uniprot id: A0A2I2ZWD7
uniprot id: G3RNP1
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9595:CENPQ
gene id: 9595:CENPQ
uniprot id: G3RW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9595:ASIC3
gene id: 9595:ASIC3
uniprot id: A0A2I2YA49
uniprot id: G3RL27
names: Subcellular Location Annotation
messages: Membrane

9595:CELSR3
gene id: 9595:CELSR3
uniprot id: A0A2I2YG79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9595:SNX5
gene id: 9595:SNX5
uniprot id: G3R0R5
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9595:SLC8A1
gene id: 9595:SLC8A1
uniprot id: A0A2I2YRZ6
uniprot id: A0A2I2ZY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9595:MRPS16
gene id: 9595:MRPS16
uniprot id: G3RGE8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9595:POGLUT2
gene id: 9595:POGLUT2
uniprot id: G3R624
names: Similarity
messages: Belongs to the KDELC family.

9595:PDCL2
gene id: 9595:PDCL2
uniprot id: G3QY16
names: Similarity
messages: Belongs to the phosducin family.

9595:PHYHIP
gene id: 9595:PHYHIP
uniprot id: G3QWI2
names: Similarity
messages: Belongs to the PHYHIP family.

9595:ACTR1A
gene id: 9595:ACTR1A
uniprot id: G3QJD6
names: Similarity
messages: Belongs to the actin family.

9595:HDDC2
gene id: 9595:HDDC2
uniprot id: G3SI01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9595:NAT2
gene id: 9595:NAT2
uniprot id: A0A4P8J5B1
uniprot id: G3QP61
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9595:EXOSC8
gene id: 9595:EXOSC8
uniprot id: G3R8A9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:CLUL1
gene id: 9595:CLUL1
uniprot id: G3QG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

9595:VIRMA
gene id: 9595:VIRMA
uniprot id: G3QVF2
names: Similarity
messages: Belongs to the vir family.

9595:GCDH
gene id: 9595:GCDH
uniprot id: G3QLJ4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:C12H12orf43
gene id: 9595:C12H12orf43
uniprot id: A0A2I2YJN0
uniprot id: G3R8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9595:CRAT
gene id: 9595:CRAT
uniprot id: A0A2I2Y8W4
uniprot id: G3RRT6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:ARTN
gene id: 9595:ARTN
uniprot id: G3RJS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9595:KRT74
gene id: 9595:KRT74
uniprot id: G3QKU7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:SHMT2
gene id: 9595:SHMT2
uniprot id: G3R410
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9595:ATP5MC3
gene id: 9595:ATP5MC3
uniprot id: A0A2I2Z561
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9595:IRAK4
gene id: 9595:IRAK4
uniprot id: G3RYR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9595:PHACTR4
gene id: 9595:PHACTR4
uniprot id: A0A2I2Y9Y9
uniprot id: A0A2I2YJB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9595:RPS26
gene id: 9595:RPS26
uniprot id: G3R7E3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:P2RY11
gene id: 9595:P2RY11
uniprot id: G3QRQ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PADI2
gene id: 9595:PADI2
uniprot id: G3RJJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:MEIS1
gene id: 9595:MEIS1
uniprot id: G3QRS0
uniprot id: G3S4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9595:ENO1
gene id: 9595:ENO1
uniprot id: G3R4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9595:E2F7
gene id: 9595:E2F7
uniprot id: G3RA82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:TRAK2
gene id: 9595:TRAK2
uniprot id: G3QKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9595:ADD3
gene id: 9595:ADD3
uniprot id: A0A2I2ZPJ2
uniprot id: G3RP35
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9595:OXCT1
gene id: 9595:OXCT1
uniprot id: G3S0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9595:APEH
gene id: 9595:APEH
uniprot id: G3R4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

9595:RFFL
gene id: 9595:RFFL
uniprot id: A0A2I2Z1D4
uniprot id: G3QNH3
names: Subcellular Location Annotation
messages: Cell membrane

9595:LOC101141950
gene id: 9595:LOC101141950
uniprot id: G3S9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GIMAP7
gene id: 9595:GIMAP7
uniprot id: G3QIU4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:UROS
gene id: 9595:UROS
uniprot id: G3R707
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9595:FOS
gene id: 9595:FOS
uniprot id: G3QE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9595:ESX1
gene id: 9595:ESX1
uniprot id: G3QMI0
names: Subcellular Location Annotation
messages: Nucleus

9595:NDUFAF4
gene id: 9595:NDUFAF4
uniprot id: A0A2I2Y870
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9595:RHD
gene id: 9595:RHD
uniprot id: Q28427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
messages: Membrane

9595:CMBL
gene id: 9595:CMBL
uniprot id: G3RE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9595:THEMIS
gene id: 9595:THEMIS
uniprot id: A0A2I2Z6H4
uniprot id: G3RI95
names: Similarity
messages: Belongs to the themis family.

9595:MRGPRF
gene id: 9595:MRGPRF
uniprot id: G3QS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9595:PPIA
gene id: 9595:PPIA
uniprot id: A0A2I2Y6I4
uniprot id: Q0ZQL0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

9595:CENPA
gene id: 9595:CENPA
uniprot id: A0A2I2Y1U4
uniprot id: G3SF93
names: Similarity
messages: Belongs to the histone H3 family.

9595:ALAS2
gene id: 9595:ALAS2
uniprot id: G3QI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9595:CPT2
gene id: 9595:CPT2
uniprot id: A0A2I2YJ86
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:COQ5
gene id: 9595:COQ5
uniprot id: G3R0B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9595:SWI5
gene id: 9595:SWI5
uniprot id: A0A2I2ZG41
names: Function
names: Similarity
messages: Belongs to the SWI5/SAE3 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.

9595:SGIP1
gene id: 9595:SGIP1
uniprot id: G3RU21
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9595:E2F4
gene id: 9595:E2F4
uniprot id: G3S5T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:PHLDA3
gene id: 9595:PHLDA3
uniprot id: A0A2I2ZJ10
names: Subcellular Location Annotation
messages: Cytoplasm

9595:OGT
gene id: 9595:OGT
uniprot id: G3RFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9595:TNNT2
gene id: 9595:TNNT2
uniprot id: A0A2I2Y409
uniprot id: A0A2I2ZBZ7
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9595:ZEB1
gene id: 9595:ZEB1
uniprot id: G3R3L7
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9595:PCYOX1L
gene id: 9595:PCYOX1L
uniprot id: G3QRN8
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9595:TMEM50A
gene id: 9595:TMEM50A
uniprot id: G3R938
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9595:LOC101148386
gene id: 9595:LOC101148386
uniprot id: G3QYN6
names: Subcellular Location Annotation
messages: Membrane

9595:GATA2
gene id: 9595:GATA2
uniprot id: G3QTJ7
names: Subcellular Location Annotation
messages: Nucleus

9595:ITGAX
gene id: 9595:ITGAX
uniprot id: G3RA67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:RAB39B
gene id: 9595:RAB39B
uniprot id: G3QS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9595:DUPD1
gene id: 9595:DUPD1
uniprot id: G3R603
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9595:KRT15
gene id: 9595:KRT15
uniprot id: A0A2I2Z0J1
names: Similarity
messages: Belongs to the intermediate filament family.

9595:PCBD1
gene id: 9595:PCBD1
uniprot id: G3RDN1
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9595:SSH3
gene id: 9595:SSH3
uniprot id: G3R6S4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9595:TSC22D4
gene id: 9595:TSC22D4
uniprot id: G3SD77
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:EIF4EBP2
gene id: 9595:EIF4EBP2
uniprot id: A0A2I2ZJX6
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9595:CENPH
gene id: 9595:CENPH
uniprot id: G3QGP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9595:CD163
gene id: 9595:CD163
uniprot id: A0A2I2ZPE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PYCR1
gene id: 9595:PYCR1
uniprot id: G3RDM4
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9595:MDFI
gene id: 9595:MDFI
uniprot id: G3QJP1
names: Similarity
messages: Belongs to the MDFI family.

9595:XKR8
gene id: 9595:XKR8
uniprot id: G3RG17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9595:BCAP31
gene id: 9595:BCAP31
uniprot id: G3QS23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9595:OPRM1
gene id: 9595:OPRM1
uniprot id: A0A2I2ZCR1
uniprot id: A0A2I2ZCV7
uniprot id: A0A2I2ZP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9595:BMP15
gene id: 9595:BMP15
uniprot id: G3QUI0
names: Similarity
messages: Belongs to the TGF-beta family.

9595:C5H5orf24
gene id: 9595:C5H5orf24
uniprot id: A0A2I2ZP93
names: Similarity
messages: Belongs to the UPF0461 family.

9595:TSC22D1
gene id: 9595:TSC22D1
uniprot id: A0A2I2ZLV8
uniprot id: G3RAR2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:RAD1
gene id: 9595:RAD1
uniprot id: G3QNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9595:SARAF
gene id: 9595:SARAF
uniprot id: G3SGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9595:CTDP1
gene id: 9595:CTDP1
uniprot id: A0A2I2ZU92
uniprot id: G3R674
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9595:CORO2B
gene id: 9595:CORO2B
uniprot id: G3RB93
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:PPIL1
gene id: 9595:PPIL1
uniprot id: G3SAE4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:USP3
gene id: 9595:USP3
uniprot id: A0A2I2Z2F6
uniprot id: G3SG64
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:LSM12
gene id: 9595:LSM12
uniprot id: A0A2I2Y1P3
names: Similarity
messages: Belongs to the LSM12 family.

9595:IFI44
gene id: 9595:IFI44
uniprot id: G3RCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI44 family.
messages: Cytoplasm

9595:GBP2
gene id: 9595:GBP2
uniprot id: G3QH70
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:NME7
gene id: 9595:NME7
uniprot id: A0A2I2YP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9595:LDHAL6A
gene id: 9595:LDHAL6A
uniprot id: A0A2I2Z7D8
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:PARP15
gene id: 9595:PARP15
uniprot id: A0A2I2ZPY1
uniprot id: G3S4Z7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:MBP
gene id: 9595:MBP
uniprot id: A0A2I2YLV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9595:TPST1
gene id: 9595:TPST1
uniprot id: G3RXV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9595:GBX2
gene id: 9595:GBX2
uniprot id: G3RTW1
names: Subcellular Location Annotation
messages: Nucleus

9595:LGI2
gene id: 9595:LGI2
uniprot id: G3S4D7
names: Subcellular Location Annotation
messages: Secreted

9595:ZNF16
gene id: 9595:ZNF16
uniprot id: A1YF12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis (By similarity).
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
messages: Nucleus

9595:UBL4A
gene id: 9595:UBL4A
uniprot id: G3RQ50
names: Subcellular Location Annotation
messages: cytosol

9595:SFT2D3
gene id: 9595:SFT2D3
uniprot id: A0A2I2YWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9595:PRKAB1
gene id: 9595:PRKAB1
uniprot id: G3RB90
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9595:USP30
gene id: 9595:USP30
uniprot id: G3R2E3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:LOC101142817
gene id: 9595:LOC101142817
uniprot id: G3SC01
names: Similarity
messages: Belongs to the pro/parathymosin family.

9595:DDIT4L
gene id: 9595:DDIT4L
uniprot id: A0A2I2YCQ7
names: Similarity
messages: Belongs to the DDIT4 family.

9595:RRAGD
gene id: 9595:RRAGD
uniprot id: G3RSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:TAS2R50
gene id: 9595:TAS2R50
uniprot id: Q646A1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9595:RCL1
gene id: 9595:RCL1
uniprot id: A0A2I2YDW0
uniprot id: G3RGD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9595:SNTA1
gene id: 9595:SNTA1
uniprot id: G3QZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9595:DGKG
gene id: 9595:DGKG
uniprot id: A0A2I2ZD87
uniprot id: A0A2I2ZRN0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9595:AKR1B1
gene id: 9595:AKR1B1
uniprot id: G3R7U6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:NFRKB
gene id: 9595:NFRKB
uniprot id: G3RH61
names: Subcellular Location Annotation
messages: Nucleus

9595:AKAP4
gene id: 9595:AKAP4
uniprot id: A0A2I2ZY16
uniprot id: G3RJC1
names: Similarity
messages: Belongs to the AKAP110 family.

9595:TCEANC2
gene id: 9595:TCEANC2
uniprot id: A0A2I2ZSS0
names: Subcellular Location Annotation
messages: Nucleus

9595:HIF1A
gene id: 9595:HIF1A
uniprot id: A0A2I2ZEQ0
uniprot id: A0A2I2ZFD2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9595:CROT
gene id: 9595:CROT
uniprot id: G3RST5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:SLC6A14
gene id: 9595:SLC6A14
uniprot id: G3R5I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:MTNR1B
gene id: 9595:MTNR1B
uniprot id: G3RDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9595:LHCGR
gene id: 9595:LHCGR
uniprot id: G3QZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9595:GCK
gene id: 9595:GCK
uniprot id: A0A2I2Y488
uniprot id: A0A2I2ZDN4
uniprot id: G3QGM3
names: Similarity
messages: Belongs to the hexokinase family.

9595:CFDP1
gene id: 9595:CFDP1
uniprot id: G3QG69
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9595:GLYCTK
gene id: 9595:GLYCTK
uniprot id: G3RIE9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9595:SLBP
gene id: 9595:SLBP
uniprot id: G3QKY0
names: Similarity
messages: Belongs to the SLBP family.

9595:NDC80
gene id: 9595:NDC80
uniprot id: G3QF61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9595:SLC25A5
gene id: 9595:SLC25A5
uniprot id: G3REE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9595:PSMD5
gene id: 9595:PSMD5
uniprot id: A0A2I2Y2G6
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9595:MYCBP
gene id: 9595:MYCBP
uniprot id: G3QSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9595:SLC14A2
gene id: 9595:SLC14A2
uniprot id: G3QFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9595:MECP2
gene id: 9595:MECP2
uniprot id: A0A2I2ZDI5
names: Function
names: Subcellular Location Annotation
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Nucleus

9595:ZDHHC5
gene id: 9595:ZDHHC5
uniprot id: G3QDT7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:ESR2
gene id: 9595:ESR2
uniprot id: A0A2I2YL00
uniprot id: A0A2I2YYU1
uniprot id: G3QKK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9595:LOC101140436
gene id: 9595:LOC101140436
uniprot id: G3QMN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ACTG1
gene id: 9595:ACTG1
uniprot id: G3RDT6
names: Similarity
messages: Belongs to the actin family.

9595:CDNF
gene id: 9595:CDNF
uniprot id: G3QEZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9595:FADS1
gene id: 9595:FADS1
uniprot id: G3RA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9595:PSMB4
gene id: 9595:PSMB4
uniprot id: G3R4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9595:FERMT1
gene id: 9595:FERMT1
uniprot id: G3RD95
names: Similarity
messages: Belongs to the kindlin family.

9595:CCL2
gene id: 9595:CCL2
uniprot id: G3RJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:CREBL2
gene id: 9595:CREBL2
uniprot id: G3SGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9595:ELF3
gene id: 9595:ELF3
uniprot id: G3RE61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:SLC27A2
gene id: 9595:SLC27A2
uniprot id: G3QTE5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:ADPRM
gene id: 9595:ADPRM
uniprot id: G3R101
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9595:THRSP
gene id: 9595:THRSP
uniprot id: G3QM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9595:PDE4C
gene id: 9595:PDE4C
uniprot id: A0A2I2ZKK2
uniprot id: A0A2I2ZN78
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:ACTR3
gene id: 9595:ACTR3
uniprot id: G3SCF3
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9595:RND3
gene id: 9595:RND3
uniprot id: A0A2I2YTX1
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9595:RFT1
gene id: 9595:RFT1
uniprot id: A0A2I2YZP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9595:SND1
gene id: 9595:SND1
uniprot id: G3R2E7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9595:KHDC1L
gene id: 9595:KHDC1L
uniprot id: G3RNX0
names: Similarity
messages: Belongs to the KHDC1 family.

9595:DHH
gene id: 9595:DHH
uniprot id: G3QY79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9595:DNAJC10
gene id: 9595:DNAJC10
uniprot id: G3R967
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9595:PTCH2
gene id: 9595:PTCH2
uniprot id: A0A2I2Z5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9595:RPS6KA3
gene id: 9595:RPS6KA3
uniprot id: G3R0F8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:DACT2
gene id: 9595:DACT2
uniprot id: G3RXL6
names: Similarity
messages: Belongs to the dapper family.

9595:ALDH1A2
gene id: 9595:ALDH1A2
uniprot id: G3QXF4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:GPR4
gene id: 9595:GPR4
uniprot id: A0A2I2YZ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HTR1E
gene id: 9595:HTR1E
uniprot id: G3SG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TMC2
gene id: 9595:TMC2
uniprot id: G3QVT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:QKI
gene id: 9595:QKI
uniprot id: G3QEM5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:CLDN1
gene id: 9595:CLDN1
uniprot id: G3RDP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:TBX22
gene id: 9595:TBX22
uniprot id: G3R0U6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:SMAGP
gene id: 9595:SMAGP
uniprot id: G3QVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:GPR37
gene id: 9595:GPR37
uniprot id: G3QP20
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LCE1B
gene id: 9595:LCE1B
uniprot id: G3S2H5
names: Similarity
messages: Belongs to the LCE family.

9595:SLC23A1
gene id: 9595:SLC23A1
uniprot id: A0A2I2YD56
names: Subcellular Location Annotation
messages: Membrane

9595:TAS2R40
gene id: 9595:TAS2R40
uniprot id: G3RK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:DZIP1
gene id: 9595:DZIP1
uniprot id: A0A2I2ZXW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9595:CACUL1
gene id: 9595:CACUL1
uniprot id: G3QGH4
names: Similarity
messages: Belongs to the cullin family.

9595:KRT73
gene id: 9595:KRT73
uniprot id: G3QWI7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:BTC
gene id: 9595:BTC
uniprot id: G3RD79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IFNG
gene id: 9595:IFNG
uniprot id: G3QT96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9595:SLC7A13
gene id: 9595:SLC7A13
uniprot id: G3QZK6
names: Subcellular Location Annotation
messages: Membrane

9595:ST8SIA2
gene id: 9595:ST8SIA2
uniprot id: A0A2I2Z248
uniprot id: G3R9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:CNOT3
gene id: 9595:CNOT3
uniprot id: G3RB45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9595:HSCB
gene id: 9595:HSCB
uniprot id: G3RLQ2
names: Similarity
messages: Belongs to the HscB family.

9595:GALNT5
gene id: 9595:GALNT5
uniprot id: G3QJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:TSHB
gene id: 9595:TSHB
uniprot id: G3R4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9595:SLC4A7
gene id: 9595:SLC4A7
uniprot id: A0A2I2YZ27
uniprot id: G3R6J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9595:PPP2R2B
gene id: 9595:PPP2R2B
uniprot id: A0A2I2YWE8
uniprot id: A0A2I2Z3T1
uniprot id: A0A2I2Z8R0
uniprot id: A0A2I2ZVK2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9595:MPDU1
gene id: 9595:MPDU1
uniprot id: A0A2I2YM40
uniprot id: G3SDB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9595:GAP43
gene id: 9595:GAP43
uniprot id: A0A2I2YYA5
uniprot id: G3SJC5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9595:RAD18
gene id: 9595:RAD18
uniprot id: G3QZ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9595:CNOT1
gene id: 9595:CNOT1
uniprot id: G3R2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9595:SLC41A1
gene id: 9595:SLC41A1
uniprot id: G3RAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9595:FOXN3
gene id: 9595:FOXN3
uniprot id: A0A2I2Y453
names: Subcellular Location Annotation
messages: Nucleus

9595:YIF1A
gene id: 9595:YIF1A
uniprot id: G3R2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9595:SLITRK1
gene id: 9595:SLITRK1
uniprot id: G3S5N8
names: Similarity
messages: Belongs to the SLITRK family.

9595:TNS1
gene id: 9595:TNS1
uniprot id: A0A2I2YUW8
uniprot id: A0A2I2ZLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9595:LOC101133641
gene id: 9595:LOC101133641
uniprot id: G3SGW3
names: Subcellular Location Annotation
messages: Membrane

9595:NEXMIF
gene id: 9595:NEXMIF
uniprot id: G3QRF1
names: Subcellular Location Annotation
messages: Nucleus

9595:MTFP1
gene id: 9595:MTFP1
uniprot id: A0A2I2ZQC3
uniprot id: G3RAB5
names: Similarity
messages: Belongs to the MTFP1 family.

9595:NKAPL
gene id: 9595:NKAPL
uniprot id: A0A2I2YR21
names: Similarity
messages: Belongs to the NKAP family.

9595:GPR119
gene id: 9595:GPR119
uniprot id: G3S749
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SUPT5H
gene id: 9595:SUPT5H
uniprot id: G3RET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9595:CRISP1
gene id: 9595:CRISP1
uniprot id: A0A2I2Z5I8
uniprot id: G3R4Q7
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ALCAM
gene id: 9595:ALCAM
uniprot id: A0A2I2ZP40
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9595:SLC7A6
gene id: 9595:SLC7A6
uniprot id: A0A2I2ZD48
names: Subcellular Location Annotation
messages: Membrane

9595:STC1
gene id: 9595:STC1
uniprot id: G3SGP0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9595:SLC39A4
gene id: 9595:SLC39A4
uniprot id: G3RJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9595:TTC4
gene id: 9595:TTC4
uniprot id: G3QRP6
names: Similarity
messages: Belongs to the TTC4 family.

9595:PER1
gene id: 9595:PER1
uniprot id: G3QSL0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:MYO6
gene id: 9595:MYO6
uniprot id: A0A2I2YUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus

9595:CXCL14
gene id: 9595:CXCL14
uniprot id: G3QK30
names: Subcellular Location Annotation
messages: Secreted

9595:AP4B1
gene id: 9595:AP4B1
uniprot id: A0A2I2YYV2
uniprot id: G3R6Z0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9595:TMEM87A
gene id: 9595:TMEM87A
uniprot id: A0A2I2ZY66
uniprot id: G3SIQ9
names: Subcellular Location Annotation
messages: Membrane

9595:RPSA
gene id: 9595:RPSA
uniprot id: G3RGD1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9595:SERPINB2
gene id: 9595:SERPINB2
uniprot id: G3SJ51
names: Similarity
messages: Belongs to the serpin family.

9595:COL4A5
gene id: 9595:COL4A5
uniprot id: A0A2I2YBW5
uniprot id: G3R653
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9595:FAM199X
gene id: 9595:FAM199X
uniprot id: G3RZE4
names: Similarity
messages: Belongs to the FAM199 family.

9595:CCDC172
gene id: 9595:CCDC172
uniprot id: G3QNB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9595:ENPP2
gene id: 9595:ENPP2
uniprot id: A0A2I2YZY5
uniprot id: G3QK63
uniprot id: G3RNC0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9595:CTNNA2
gene id: 9595:CTNNA2
uniprot id: A0A2I2Y9A3
uniprot id: A0A2I2YNA1
uniprot id: G3RRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9595:LOC101132256
gene id: 9595:LOC101132256
uniprot id: G3SEH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CYFIP2
gene id: 9595:CYFIP2
uniprot id: G3RM65
uniprot id: G3SAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9595:MGST1
gene id: 9595:MGST1
uniprot id: A0A2I2ZTM6
uniprot id: G3QV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9595:BEX5
gene id: 9595:BEX5
uniprot id: G3SE44
names: Similarity
messages: Belongs to the BEX family.

9595:ZDHHC3
gene id: 9595:ZDHHC3
uniprot id: A0A2I2YYI8
uniprot id: A0A2I2ZUD4
uniprot id: G3RCD2
uniprot id: G3SAX1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:VOPP1
gene id: 9595:VOPP1
uniprot id: G3RP07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane

9595:SERPINA10
gene id: 9595:SERPINA10
uniprot id: G3QJZ0
names: Similarity
messages: Belongs to the serpin family.

9595:KANSL2
gene id: 9595:KANSL2
uniprot id: A0A2I2ZL13
uniprot id: G3RBB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9595:ANO4
gene id: 9595:ANO4
uniprot id: G3QD80
uniprot id: G3RP36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:RELT
gene id: 9595:RELT
uniprot id: G3R437
names: Similarity
messages: Belongs to the RELT family.

9595:DCTPP1
gene id: 9595:DCTPP1
uniprot id: G3RMI7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9595:TMEM30A
gene id: 9595:TMEM30A
uniprot id: G3QLR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

9595:ADAMTS3
gene id: 9595:ADAMTS3
uniprot id: G3QLZ8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:METTL11B
gene id: 9595:METTL11B
uniprot id: G3R7V8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9595:CDK5R1
gene id: 9595:CDK5R1
uniprot id: A0A2I2Z9I6
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9595:CRY2
gene id: 9595:CRY2
uniprot id: G3QIP3
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9595:TENT5A
gene id: 9595:TENT5A
uniprot id: G3QFV6
names: Similarity
messages: Belongs to the TENT family.

9595:PGC
gene id: 9595:PGC
uniprot id: G3QJP9
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

9595:HACL1
gene id: 9595:HACL1
uniprot id: A0A2I2Z202
uniprot id: G3R5G3
names: Similarity
messages: Belongs to the TPP enzyme family.

9595:CSRNP2
gene id: 9595:CSRNP2
uniprot id: G3R4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9595:PDCD4
gene id: 9595:PDCD4
uniprot id: G3S1V1
names: Similarity
messages: Belongs to the PDCD4 family.

9595:AK1
gene id: 9595:AK1
uniprot id: A0A2I2YKU8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9595:TULP3
gene id: 9595:TULP3
uniprot id: A0A2I2YNT5
uniprot id: G3RQT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9595:METTL1
gene id: 9595:METTL1
uniprot id: A0A2I2YEB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-52 inactivates its catalytic activity but does not affect the interaction with WDR4.

9595:LOC101143132
gene id: 9595:LOC101143132
uniprot id: G3QYB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ZDHHC6
gene id: 9595:ZDHHC6
uniprot id: G3SHQ9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:SLC26A6
gene id: 9595:SLC26A6
uniprot id: A0A2I2Y4N0
uniprot id: G3SBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane

9595:DOCK5
gene id: 9595:DOCK5
uniprot id: G3QP98
names: Similarity
messages: Belongs to the DOCK family.

9595:GIMAP6
gene id: 9595:GIMAP6
uniprot id: G3QEB2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:FKTN
gene id: 9595:FKTN
uniprot id: G3QS78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9595:GIPR
gene id: 9595:GIPR
uniprot id: G3RJ74
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101146890
gene id: 9595:LOC101146890
uniprot id: A0A2I2Y4K8
uniprot id: A0A2I2Z8Q8
uniprot id: G3QRS3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9595:CARMIL3
gene id: 9595:CARMIL3
uniprot id: G3RIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9595:SLC35A5
gene id: 9595:SLC35A5
uniprot id: G3SGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9595:RNF10
gene id: 9595:RNF10
uniprot id: G3S990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9595:CHRNB4
gene id: 9595:CHRNB4
uniprot id: G3R4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:NGFR
gene id: 9595:NGFR
uniprot id: G3QZD4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PRR15L
gene id: 9595:PRR15L
uniprot id: A0A2I2ZIQ4
names: Similarity
messages: Belongs to the PRR15 family.

9595:MARVELD2
gene id: 9595:MARVELD2
uniprot id: A0A2I2Y6F8
uniprot id: G3RHQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:KIAA1324L
gene id: 9595:KIAA1324L
uniprot id: A0A2I2YCM5
uniprot id: G3RFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9595:GRM4
gene id: 9595:GRM4
uniprot id: G3QRF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:SPATS2L
gene id: 9595:SPATS2L
uniprot id: A0A2I2YBB9
uniprot id: G3QSZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9595:LOC101133676
gene id: 9595:LOC101133676
uniprot id: G3RKL7
names: Subcellular Location Annotation
messages: Membrane

9595:FAAH2
gene id: 9595:FAAH2
uniprot id: G3SJZ0
names: Similarity
messages: Belongs to the amidase family.

9595:DPYSL5
gene id: 9595:DPYSL5
uniprot id: A0A2I2Z098
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9595:MET
gene id: 9595:MET
uniprot id: A0A2I2Z3S5
uniprot id: Q2IBF2
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9595:ATP5MF
gene id: 9595:ATP5MF
uniprot id: A0A2I2YV24
uniprot id: A0A2I2ZCK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9595:KPNA1
gene id: 9595:KPNA1
uniprot id: G3RIQ5
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9595:PHOSPHO2
gene id: 9595:PHOSPHO2
uniprot id: G3QTS4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9595:MAPK1IP1L
gene id: 9595:MAPK1IP1L
uniprot id: A0A2I2Y506
names: Similarity
messages: Belongs to the MISS family.

9595:VIPAS39
gene id: 9595:VIPAS39
uniprot id: G3RK70
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9595:TMEM70
gene id: 9595:TMEM70
uniprot id: G3RH79
names: Similarity
messages: Belongs to the TMEM70 family.

9595:SRSF4
gene id: 9595:SRSF4
uniprot id: G3QJ23
names: Similarity
messages: Belongs to the splicing factor SR family.

9595:LPAR6
gene id: 9595:LPAR6
uniprot id: G3RRG1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:CREG1
gene id: 9595:CREG1
uniprot id: G3QIA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9595:LOC101134485
gene id: 9595:LOC101134485
uniprot id: A0A2I2Z6F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CD74
gene id: 9595:CD74
uniprot id: G3R7S6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FOXM1
gene id: 9595:FOXM1
uniprot id: G3R1V7
uniprot id: G3SAZ9
names: Subcellular Location Annotation
messages: Nucleus

9595:GARS1
gene id: 9595:GARS1
uniprot id: G3QQF1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9595:TMEM59
gene id: 9595:TMEM59
uniprot id: G3QY76
uniprot id: G3S6B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:RRM2
gene id: 9595:RRM2
uniprot id: A0A2I2YNS8
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9595:RNFT2
gene id: 9595:RNFT2
uniprot id: A0A2I2YZ03
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101130783
gene id: 9595:LOC101130783
uniprot id: G3QM00
names: Similarity
messages: Belongs to the TCAF family.

9595:DTX3L
gene id: 9595:DTX3L
uniprot id: G3RIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9595:KDM1B
gene id: 9595:KDM1B
uniprot id: G3QLA3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:FAM151A
gene id: 9595:FAM151A
uniprot id: G3R390
names: Similarity
messages: Belongs to the FAM151 family.

9595:PDRG1
gene id: 9595:PDRG1
uniprot id: G3S683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9595:CPLX4
gene id: 9595:CPLX4
uniprot id: G3QV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:SLC39A13
gene id: 9595:SLC39A13
uniprot id: G3S3Y4
names: Subcellular Location Annotation
messages: Membrane

9595:KLC4
gene id: 9595:KLC4
uniprot id: G3R4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9595:SERF2
gene id: 9595:SERF2
uniprot id: A0A2I2Y1V5
names: Similarity
messages: Belongs to the SERF family.

9595:RAB18
gene id: 9595:RAB18
uniprot id: G3QYG9
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9595:TOMM40L
gene id: 9595:TOMM40L
uniprot id: A0A2I2Z5F0
uniprot id: G3QSG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:DBT
gene id: 9595:DBT
uniprot id: G3S1Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9595:EIF3G
gene id: 9595:EIF3G
uniprot id: G3QRQ9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9595:ATP6AP2
gene id: 9595:ATP6AP2
uniprot id: G3S9T4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9595:USP13
gene id: 9595:USP13
uniprot id: G3SKD8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:RSPO1
gene id: 9595:RSPO1
uniprot id: G3QXJ8
names: Similarity
messages: Belongs to the R-spondin family.

9595:CALHM5
gene id: 9595:CALHM5
uniprot id: A0A2I2Z0T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:FNIP2
gene id: 9595:FNIP2
uniprot id: G3S532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9595:UBQLN2
gene id: 9595:UBQLN2
uniprot id: G3RLD1
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9595:LOC101150037
gene id: 9595:LOC101150037
uniprot id: G3RU27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:G6PD
gene id: 9595:G6PD
uniprot id: G3RMM2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9595:AKAP13
gene id: 9595:AKAP13
uniprot id: A0A2I2YLQ8
names: Subcellular Location Annotation
messages: Cytoplasm

9595:HOXD10
gene id: 9595:HOXD10
uniprot id: G3QG73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9595:LOC101133708
gene id: 9595:LOC101133708
uniprot id: A0A2I2ZXD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:YWHAB
gene id: 9595:YWHAB
uniprot id: G3QPJ3
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:ABLIM1
gene id: 9595:ABLIM1
uniprot id: A0A2I2YFZ2
names: Subcellular Location Annotation
messages: Cytoplasm

9595:RAG1
gene id: 9595:RAG1
uniprot id: A0A2I2ZGP8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9595:LHX9
gene id: 9595:LHX9
uniprot id: A0A2I2YZK2
uniprot id: A0A2I2Z1J5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101145021
gene id: 9595:LOC101145021
uniprot id: A0A2I2Z715
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:B3GALT2
gene id: 9595:B3GALT2
uniprot id: G3S7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:IP6K3
gene id: 9595:IP6K3
uniprot id: G3RJJ9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9595:AIMP2
gene id: 9595:AIMP2
uniprot id: A0A2I2YMA9
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9595:TASOR
gene id: 9595:TASOR
uniprot id: A0A2I2YW35
uniprot id: G3R6V4
names: Similarity
messages: Belongs to the TASOR family.

9595:SLC18A1
gene id: 9595:SLC18A1
uniprot id: A0A2I2YAD0
uniprot id: A0A2I2YL50
uniprot id: G3QMR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:CIAO2B
gene id: 9595:CIAO2B
uniprot id: G3R9H1
names: Similarity
messages: Belongs to the MIP18 family.

9595:UGT3A2
gene id: 9595:UGT3A2
uniprot id: G3QKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:NSUN5
gene id: 9595:NSUN5
uniprot id: G3R7U5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9595:PAGE4
gene id: 9595:PAGE4
uniprot id: G3QDC4
names: Similarity
messages: Belongs to the GAGE family.

9595:SMIM19
gene id: 9595:SMIM19
uniprot id: A0A2I2YNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9595:TNFSF10
gene id: 9595:TNFSF10
uniprot id: G3RF33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9595:SUPV3L1
gene id: 9595:SUPV3L1
uniprot id: G3QRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9595:FGF2
gene id: 9595:FGF2
uniprot id: A0A2I2YE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

9595:TNFSF13B
gene id: 9595:TNFSF13B
uniprot id: A0A2I2Y9Z0
uniprot id: G3RM11
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:ANAPC5
gene id: 9595:ANAPC5
uniprot id: G3QZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9595:HEATR1
gene id: 9595:HEATR1
uniprot id: A0A2I2Z2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9595:TMEM107
gene id: 9595:TMEM107
uniprot id: A0A2I2ZAN6
names: Subcellular Location Annotation
messages: Membrane

9595:GASK1A
gene id: 9595:GASK1A
uniprot id: G3QEK9
names: Similarity
messages: Belongs to the GASK family.

9595:SNX33
gene id: 9595:SNX33
uniprot id: G3RIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9595:SLC4A9
gene id: 9595:SLC4A9
uniprot id: G3QDG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9595:UBR2
gene id: 9595:UBR2
uniprot id: A0A2I2ZWA2
uniprot id: G3QNA5
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9595:EVC
gene id: 9595:EVC
uniprot id: G3RCZ5
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9595:MED15
gene id: 9595:MED15
uniprot id: G3QNJ0
uniprot id: G3S027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:ATP1A2
gene id: 9595:ATP1A2
uniprot id: G3S409
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:INTS9
gene id: 9595:INTS9
uniprot id: G3SJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9595:TMEM63B
gene id: 9595:TMEM63B
uniprot id: A0A2I2ZSJ5
uniprot id: G3QKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9595:TSPAN6
gene id: 9595:TSPAN6
uniprot id: A0A2I2YYN6
uniprot id: G3R3D7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:RAD23B
gene id: 9595:RAD23B
uniprot id: G3QJ86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9595:ASB8
gene id: 9595:ASB8
uniprot id: G3QUD1
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9595:SLC22A8
gene id: 9595:SLC22A8
uniprot id: G3RTH7
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9595:NPPC
gene id: 9595:NPPC
uniprot id: G3RPI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9595:STK4
gene id: 9595:STK4
uniprot id: G3RCG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9595:PCNX4
gene id: 9595:PCNX4
uniprot id: G3SD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9595:TSPAN5
gene id: 9595:TSPAN5
uniprot id: G3SGT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:DAO
gene id: 9595:DAO
uniprot id: G3RBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9595:MANBA
gene id: 9595:MANBA
uniprot id: G3R2R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9595:KCNJ13
gene id: 9595:KCNJ13
uniprot id: G3R0D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:LOC101140366
gene id: 9595:LOC101140366
uniprot id: G3RAE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:APPL2
gene id: 9595:APPL2
uniprot id: G3RBH7
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9595:TNFAIP3
gene id: 9595:TNFAIP3
uniprot id: G3QLD1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:MRPL1
gene id: 9595:MRPL1
uniprot id: G3QG37
names: Subcellular Location Annotation
messages: Mitochondrion

9595:SCNN1B
gene id: 9595:SCNN1B
uniprot id: G3QGR0
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101137306
gene id: 9595:LOC101137306
uniprot id: G3RX17
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9595:SLC2A11
gene id: 9595:SLC2A11
uniprot id: A0A2I2ZBH9
uniprot id: G3R8K0
uniprot id: G3RY02
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9595:EHD4
gene id: 9595:EHD4
uniprot id: G3R825
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9595:STK38L
gene id: 9595:STK38L
uniprot id: G3QHG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:VIM
gene id: 9595:VIM
uniprot id: G3R2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9595:VEGFD
gene id: 9595:VEGFD
uniprot id: G3QJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9595:SRP9
gene id: 9595:SRP9
uniprot id: G3R7D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9595:KCNB1
gene id: 9595:KCNB1
uniprot id: G3QVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9595:DLL4
gene id: 9595:DLL4
uniprot id: G3SK70
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:FICD
gene id: 9595:FICD
uniprot id: G3R7D2
names: Similarity
messages: Belongs to the fic family.

9595:PRKACB
gene id: 9595:PRKACB
uniprot id: A0A2I2YCG8
uniprot id: A0A2I2YE73
uniprot id: A0A2I2Z6Y0
uniprot id: A0A2I2ZBE7
uniprot id: A0A2I2ZC53
uniprot id: A0A2I2ZDX1
uniprot id: G3SC72
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9595:SLC25A36
gene id: 9595:SLC25A36
uniprot id: G3SAY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:CAMKMT
gene id: 9595:CAMKMT
uniprot id: A0A2I2Z1G4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:PRKRIP1
gene id: 9595:PRKRIP1
uniprot id: G3QXK8
names: Similarity
messages: Belongs to the PRKRIP1 family.

9595:MAP2K3
gene id: 9595:MAP2K3
uniprot id: G3QEG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ARL14
gene id: 9595:ARL14
uniprot id: A0A2I2ZPU2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9595:EXOSC2
gene id: 9595:EXOSC2
uniprot id: G3R4V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9595:ADAM23
gene id: 9595:ADAM23
uniprot id: A0A2I2YGG8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PRIM1
gene id: 9595:PRIM1
uniprot id: G3RCL3
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9595:LOC101127721
gene id: 9595:LOC101127721
uniprot id: G3SAJ6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:SLC46A1
gene id: 9595:SLC46A1
uniprot id: A0A2I2YRU8
uniprot id: G3R696
names: Subcellular Location Annotation
messages: Membrane

9595:TP63
gene id: 9595:TP63
uniprot id: A0A2I2Y444
uniprot id: A0A2I2Y5B0
uniprot id: A0A2I2Z434
uniprot id: A0A2I2ZLA8
uniprot id: G3QQY2
uniprot id: G3RXL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9595:PRKAA2
gene id: 9595:PRKAA2
uniprot id: G3R126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

9595:PLCD4
gene id: 9595:PLCD4
uniprot id: A0A2I2ZVA6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9595:ELMO3
gene id: 9595:ELMO3
uniprot id: G3R8E4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9595:NAPEPLD
gene id: 9595:NAPEPLD
uniprot id: G3S3Q9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9595:PLPP3
gene id: 9595:PLPP3
uniprot id: G3QDI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:TCP10L
gene id: 9595:TCP10L
uniprot id: A0A2I2Y236
names: Similarity
messages: Belongs to the TCP10 family.

9595:SNX21
gene id: 9595:SNX21
uniprot id: A0A2I2YZQ2
uniprot id: A0A2I2ZWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9595:DERL3
gene id: 9595:DERL3
uniprot id: G3QEY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9595:LPIN3
gene id: 9595:LPIN3
uniprot id: A0A2I2ZWF3
names: Similarity
messages: Belongs to the lipin family.

9595:ZNF449
gene id: 9595:ZNF449
uniprot id: A1YEQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:RIBC1
gene id: 9595:RIBC1
uniprot id: G3RW36
names: Similarity
messages: Belongs to the RIB43A family.

9595:MRM2
gene id: 9595:MRM2
uniprot id: G3SBN6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

9595:CHPF
gene id: 9595:CHPF
uniprot id: G3QJT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9595:ITGAE
gene id: 9595:ITGAE
uniprot id: G3QWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:TULP1
gene id: 9595:TULP1
uniprot id: A0A2I2YQ35
uniprot id: A0A2I2ZS55
names: Similarity
messages: Belongs to the TUB family.

9595:TMPRSS4
gene id: 9595:TMPRSS4
uniprot id: A0A2I2ZXE2
uniprot id: G3SF67
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:BEX1
gene id: 9595:BEX1
uniprot id: G3SBZ1
names: Similarity
messages: Belongs to the BEX family.

9595:DYSF
gene id: 9595:DYSF
uniprot id: A0A2I2Y9X0
uniprot id: A0A2I2ZVY1
uniprot id: G3QWB2
uniprot id: G3S7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:TMTC2
gene id: 9595:TMTC2
uniprot id: A0A2I2YJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9595:PELI1
gene id: 9595:PELI1
uniprot id: G3RCA2
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9595:HSD3B2
gene id: 9595:HSD3B2
uniprot id: G3QLD9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9595:CDH8
gene id: 9595:CDH8
uniprot id: G3S1A0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:MAPK10
gene id: 9595:MAPK10
uniprot id: A0A2I2ZN14
uniprot id: G3QKV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9595:PLCD1
gene id: 9595:PLCD1
uniprot id: G3QMJ5
uniprot id: G3RXS3
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9595:GDPD2
gene id: 9595:GDPD2
uniprot id: G3QH93
uniprot id: G3S187
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:NUPR1
gene id: 9595:NUPR1
uniprot id: G3QD60
names: Similarity
messages: Belongs to the NUPR family.

9595:NT5C3A
gene id: 9595:NT5C3A
uniprot id: A0A2I2ZQ04
uniprot id: G3S3P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9595:CRYAB
gene id: 9595:CRYAB
uniprot id: G3QR27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9595:PSPC1
gene id: 9595:PSPC1
uniprot id: G3QLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9595:KCNH7
gene id: 9595:KCNH7
uniprot id: A0A2I2ZMI5
uniprot id: A0A2I2ZQ14
names: Subcellular Location Annotation
messages: Membrane

9595:ADRA1A
gene id: 9595:ADRA1A
uniprot id: A0A2I2YMC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9595:PEX5
gene id: 9595:PEX5
uniprot id: G3QL79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9595:BRK1
gene id: 9595:BRK1
uniprot id: G3RZT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9595:DHTKD1
gene id: 9595:DHTKD1
uniprot id: A0A2I2YYP5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9595:LOC101134783
gene id: 9595:LOC101134783
uniprot id: G3QGF9
uniprot id: G3SB77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Nucleus

9595:GUCY2F
gene id: 9595:GUCY2F
uniprot id: G3QV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9595:SCAMP3
gene id: 9595:SCAMP3
uniprot id: G3R1X9
uniprot id: G3SG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9595:DSC1
gene id: 9595:DSC1
uniprot id: G3RCH6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9595:KEG83 p02
gene id: 9595:KEG83_p02
uniprot id: G3SJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9595:FGFR4
gene id: 9595:FGFR4
uniprot id: G3RPD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:SLC16A1
gene id: 9595:SLC16A1
uniprot id: G3RHM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9595:LOC101143276
gene id: 9595:LOC101143276
uniprot id: G3RL98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HOXD4
gene id: 9595:HOXD4
uniprot id: A1YER7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Forms a DNA-binding heterodimer with transcription factor PBX1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:NQO2
gene id: 9595:NQO2
uniprot id: A0A2I2YLC9
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9595:TMC6
gene id: 9595:TMC6
uniprot id: G3QVR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:NR2E1
gene id: 9595:NR2E1
uniprot id: G3RWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:SLC16A13
gene id: 9595:SLC16A13
uniprot id: G3QG09
names: Subcellular Location Annotation
messages: Membrane

9595:SLC6A1
gene id: 9595:SLC6A1
uniprot id: G3QDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:ERG
gene id: 9595:ERG
uniprot id: A0A2I2YSF9
uniprot id: A0A2I2ZDB4
uniprot id: G3R6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:ZPR1
gene id: 9595:ZPR1
uniprot id: G3QEG0
names: Similarity
messages: Belongs to the ZPR1 family.

9595:PAQR7
gene id: 9595:PAQR7
uniprot id: A0A2I2YCV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:VDAC3
gene id: 9595:VDAC3
uniprot id: G3QHR8
uniprot id: G3RV76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9595:LCMT1
gene id: 9595:LCMT1
uniprot id: G3QYE2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9595:ST3GAL1
gene id: 9595:ST3GAL1
uniprot id: G3RUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:MTM1
gene id: 9595:MTM1
uniprot id: G3RAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9595:TNFRSF9
gene id: 9595:TNFRSF9
uniprot id: G3RKZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101153433
gene id: 9595:LOC101153433
uniprot id: G3QZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CALHM2
gene id: 9595:CALHM2
uniprot id: G3R7M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:HOMER1
gene id: 9595:HOMER1
uniprot id: G3QFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9595:TSPAN19
gene id: 9595:TSPAN19
uniprot id: G3RZD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ABCD3
gene id: 9595:ABCD3
uniprot id: G3SJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9595:GDF3
gene id: 9595:GDF3
uniprot id: G3R9N1
names: Similarity
messages: Belongs to the TGF-beta family.

9595:INCENP
gene id: 9595:INCENP
uniprot id: A0A2I2Z5V9
uniprot id: G3S276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9595:LOC101143888
gene id: 9595:LOC101143888
uniprot id: G3R150
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:LCE5A
gene id: 9595:LCE5A
uniprot id: G3S955
names: Similarity
messages: Belongs to the LCE family.

9595:DCT
gene id: 9595:DCT
uniprot id: G3S218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9595:RPS16
gene id: 9595:RPS16
uniprot id: G3S6Q1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9595:PTPN2
gene id: 9595:PTPN2
uniprot id: A0A2I2Y272
uniprot id: G3RMA5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9595:SLC12A5
gene id: 9595:SLC12A5
uniprot id: G3SBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:LOC101143204
gene id: 9595:LOC101143204
uniprot id: A0A2I2ZQT0
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9595:ARSL
gene id: 9595:ARSL
uniprot id: A0A2I2Z587
uniprot id: G3RJQ1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:PTGER1
gene id: 9595:PTGER1
uniprot id: G3S6M0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:ST8SIA3
gene id: 9595:ST8SIA3
uniprot id: A0A2I2YE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:EEF1B2
gene id: 9595:EEF1B2
uniprot id: G3QVR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9595:DCK
gene id: 9595:DCK
uniprot id: A0A2I2YPC2
names: Similarity
messages: Belongs to the DCK/DGK family.

9595:IRX1
gene id: 9595:IRX1
uniprot id: G3SJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9595:SNX10
gene id: 9595:SNX10
uniprot id: G3S6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9595:CRYGA
gene id: 9595:CRYGA
uniprot id: G3RM47
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:LOC101126984
gene id: 9595:LOC101126984
uniprot id: A0A2I2ZES8
uniprot id: G3REV2
uniprot id: G3RUR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9595:QSOX1
gene id: 9595:QSOX1
uniprot id: A0A2I2ZYR1
uniprot id: G3R3B5
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9595:TMEM88
gene id: 9595:TMEM88
uniprot id: G3RH25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9595:PROX1
gene id: 9595:PROX1
uniprot id: G3RGL5
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC23A2
gene id: 9595:SLC23A2
uniprot id: G3QXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9595:ORC2
gene id: 9595:ORC2
uniprot id: A0A2I2ZLE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9595:YIPF5
gene id: 9595:YIPF5
uniprot id: G3RZC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9595:FXYD4
gene id: 9595:FXYD4
uniprot id: G3R5L8
names: Similarity
messages: Belongs to the FXYD family.

9595:DEFB118
gene id: 9595:DEFB118
uniprot id: A4H220
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (By similarity). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (By similarity). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (By similarity). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (By similarity). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (By similarity).
messages: Secreted
messages: The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity.

9595:PTPRB
gene id: 9595:PTPRB
uniprot id: A0A2I2Y937
uniprot id: G3QTY6
uniprot id: G3RMF8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9595:MAATS1
gene id: 9595:MAATS1
uniprot id: G3R2Z4
names: Similarity
messages: Belongs to the CFAP91 family.

9595:EYA4
gene id: 9595:EYA4
uniprot id: A0A2I2Z304
uniprot id: A0A2I2ZPX3
uniprot id: A0A2I2ZWN3
uniprot id: G3RCE6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9595:POLR3G
gene id: 9595:POLR3G
uniprot id: A0A2I2ZHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:COL4A1
gene id: 9595:COL4A1
uniprot id: G3RA04
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9595:NDUFA13
gene id: 9595:NDUFA13
uniprot id: Q0MQ89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.
messages: Mitochondrion inner membrane
messages: Nucleus

9595:MCTP2
gene id: 9595:MCTP2
uniprot id: A0A2I2ZM06
names: Subcellular Location Annotation
messages: Membrane

9595:SCGN
gene id: 9595:SCGN
uniprot id: G3QEN6
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9595:UBE2G1
gene id: 9595:UBE2G1
uniprot id: A0A2I2ZY55
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:FIP1L1
gene id: 9595:FIP1L1
uniprot id: A0A2I2Y6Z7
uniprot id: G3SBL8
uniprot id: G3SJN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9595:SLC2A2
gene id: 9595:SLC2A2
uniprot id: G3SES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9595:LOC101142284
gene id: 9595:LOC101142284
uniprot id: G3R2J7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:HMGN2
gene id: 9595:HMGN2
uniprot id: G3QF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:FAM91A1
gene id: 9595:FAM91A1
uniprot id: G3RUG9
names: Similarity
messages: Belongs to the FAM91 family.

9595:KCNJ8
gene id: 9595:KCNJ8
uniprot id: G3R0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:NAE1
gene id: 9595:NAE1
uniprot id: A0A2I2YN42
uniprot id: G3QTC6
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9595:QRFPR
gene id: 9595:QRFPR
uniprot id: G3QYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:DPY19L3
gene id: 9595:DPY19L3
uniprot id: G3R1A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9595:TDGF1
gene id: 9595:TDGF1
uniprot id: G3QLN2
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101127738
gene id: 9595:LOC101127738
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PLEKHA8
gene id: 9595:PLEKHA8
uniprot id: A0A2I2YJM2
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9595:EBF2
gene id: 9595:EBF2
uniprot id: G3QGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9595:CREBBP
gene id: 9595:CREBBP
uniprot id: A0A2I2YD30
names: Subcellular Location Annotation
messages: Cytoplasm

9595:PFN1
gene id: 9595:PFN1
uniprot id: G3S0W1
names: Similarity
messages: Belongs to the profilin family.

9595:ADA2
gene id: 9595:ADA2
uniprot id: A0A2I2YCW0
uniprot id: G3QXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9595:SSBP4
gene id: 9595:SSBP4
uniprot id: A0A2I2Z4A3
uniprot id: G3RL86
names: Subcellular Location Annotation
messages: Nucleus

9595:RIDA
gene id: 9595:RIDA
uniprot id: G3QFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9595:STARD3
gene id: 9595:STARD3
uniprot id: G3QW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:SNRNP200
gene id: 9595:SNRNP200
uniprot id: G3QR47
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9595:PNPLA4
gene id: 9595:PNPLA4
uniprot id: G3QRQ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CTTNBP2
gene id: 9595:CTTNBP2
uniprot id: G3RG49
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9595:SLC30A2
gene id: 9595:SLC30A2
uniprot id: G3RJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:HOMER2
gene id: 9595:HOMER2
uniprot id: G3RI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9595:RPS3
gene id: 9595:RPS3
uniprot id: G3QUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

9595:RARB
gene id: 9595:RARB
uniprot id: G3S8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:NRXN3
gene id: 9595:NRXN3
uniprot id: A0A2I2Y222
uniprot id: A0A2I2ZRG5
uniprot id: A0A2I2ZVI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:OLFM2
gene id: 9595:OLFM2
uniprot id: G3QT74
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9595:MRPL42
gene id: 9595:MRPL42
uniprot id: G3RSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9595:HAMP
gene id: 9595:HAMP
uniprot id: G3QEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9595:HOXA5
gene id: 9595:HOXA5
uniprot id: G3QIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:NUDT19
gene id: 9595:NUDT19
uniprot id: G3QXQ6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9595:EMC8
gene id: 9595:EMC8
uniprot id: A0A2I2ZV79
uniprot id: G3RLC5
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9595:NLRP12
gene id: 9595:NLRP12
uniprot id: A0A2I2YWE6
uniprot id: G3R0J4
names: Similarity
messages: Belongs to the NLRP family.

9595:PALM2AKAP2
gene id: 9595:PALM2AKAP2
uniprot id: A0A2I2ZUV6
names: Similarity
messages: Belongs to the paralemmin family.

9595:ACKR3
gene id: 9595:ACKR3
uniprot id: G3QNR5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:A4GALT
gene id: 9595:A4GALT
uniprot id: G3R1Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9595:TAS2R10
gene id: 9595:TAS2R10
uniprot id: G3R3K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:EMC2
gene id: 9595:EMC2
uniprot id: G3RR20
uniprot id: G3S2S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9595:LOC101144727
gene id: 9595:LOC101144727
uniprot id: G3QWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9595:RBM42
gene id: 9595:RBM42
uniprot id: A0A2I2YME1
uniprot id: G3RVH6
names: Similarity
messages: Belongs to the RRM RBM42 family.

9595:PSKH1
gene id: 9595:PSKH1
uniprot id: G3RDE0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:DPH2
gene id: 9595:DPH2
uniprot id: G3S888
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9595:GGACT
gene id: 9595:GGACT
uniprot id: A0A2I2Z8I1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9595:ESCO2
gene id: 9595:ESCO2
uniprot id: G3R2L3
names: Subcellular Location Annotation
messages: Nucleus

9595:ZBED9
gene id: 9595:ZBED9
uniprot id: G3QIV7
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC5A10
gene id: 9595:SLC5A10
uniprot id: A0A2I2ZVK0
uniprot id: G3RAD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9595:SLITRK6
gene id: 9595:SLITRK6
uniprot id: G3SHZ6
names: Similarity
messages: Belongs to the SLITRK family.

9595:TLE3
gene id: 9595:TLE3
uniprot id: G3SBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9595:LSR
gene id: 9595:LSR
uniprot id: A0A2I2ZDH9
uniprot id: G3RQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9595:MSH6
gene id: 9595:MSH6
uniprot id: G3RSZ9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9595:LCE1D
gene id: 9595:LCE1D
uniprot id: G3S6R1
names: Similarity
messages: Belongs to the LCE family.

9595:MYO3A
gene id: 9595:MYO3A
uniprot id: G3QW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton