9555:ANXA6
gene id: 9555:ANXA6
uniprot id: A0A096MXR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9555:TMX2
gene id: 9555:TMX2
uniprot id: A0A096N8F9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9555:PTGER4
gene id: 9555:PTGER4
uniprot id: A0A096N4Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9555:PPFIA3
gene id: 9555:PPFIA3
uniprot id: A0A0A0MW11
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9555:VAMP3
gene id: 9555:VAMP3
uniprot id: A0A096MT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9555:BGN
gene id: 9555:BGN
uniprot id: A0A096NEE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9555:SLC17A1
gene id: 9555:SLC17A1
uniprot id: A0A096NLF0
uniprot id: A0A2I3MJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9555:RORC
gene id: 9555:RORC
uniprot id: A0A096MPI9
uniprot id: A0A2I3N556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:B3GLCT
gene id: 9555:B3GLCT
uniprot id: A0A2I3MN33
uniprot id: A0A2I3NBZ3
names: Subcellular Location Annotation
messages: Membrane

9555:LOC108580413
gene id: 9555:LOC108580413
uniprot id: A0A096MLJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:SNRPA
gene id: 9555:SNRPA
uniprot id: A0A0A0MVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9555:FOS
gene id: 9555:FOS
uniprot id: A0A2I3MWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9555:POLA2
gene id: 9555:POLA2
uniprot id: A0A096N2C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9555:FRRS1
gene id: 9555:FRRS1
uniprot id: A0A096N3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9555:AKT3
gene id: 9555:AKT3
uniprot id: A0A096MRG7
uniprot id: A0A8I5NSS2
uniprot id: A0A8I5R117
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9555:NRG1
gene id: 9555:NRG1
uniprot id: A0A096NYH2
uniprot id: A0A2I3MB55
uniprot id: A0A2I3MB56
uniprot id: A0A2I3MCM1
uniprot id: A0A2I3ND73
uniprot id: A0A2I3NI55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9555:TCEA2
gene id: 9555:TCEA2
uniprot id: A0A096NN28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9555:ALKBH5
gene id: 9555:ALKBH5
uniprot id: A0A096P330
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Monomer.
messages: Nucleus speckle

9555:FGR
gene id: 9555:FGR
uniprot id: A0A2I3LD87
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:NT5E
gene id: 9555:NT5E
uniprot id: A0A096NQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9555:UBN2
gene id: 9555:UBN2
uniprot id: A0A096NXX7
names: Similarity
messages: Belongs to the ubinuclein family.

9555:OR52E2
gene id: 9555:OR52E2
uniprot id: A9L8W8
names: Subcellular Location Annotation
messages: Membrane

9555:LOC100999946
gene id: 9555:LOC100999946
uniprot id: A0A096NCF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TRPC3
gene id: 9555:TRPC3
uniprot id: A0A096N979
uniprot id: A0A2I3N089
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101008711
gene id: 9555:LOC101008711
uniprot id: A0A096NEK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SNRNP200
gene id: 9555:SNRNP200
uniprot id: A0A096NDJ1
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9555:PEX10
gene id: 9555:PEX10
uniprot id: A0A096N6G6
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9555:ATP2A2
gene id: 9555:ATP2A2
uniprot id: A0A096N124
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9555:CEP70
gene id: 9555:CEP70
uniprot id: A0A096MWL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9555:RIN2
gene id: 9555:RIN2
uniprot id: A0A2I3LH19
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9555:ASAH2
gene id: 9555:ASAH2
uniprot id: A0A096P598
names: Similarity
messages: Belongs to the neutral ceramidase family.

9555:LOC101008754
gene id: 9555:LOC101008754
uniprot id: A0A096MLZ2
names: Similarity
messages: Belongs to the histone H2B family.

9555:GRHL1
gene id: 9555:GRHL1
uniprot id: A0A096NIY7
uniprot id: A0A2I3ND43
names: Subcellular Location Annotation
messages: Nucleus

9555:MOB3B
gene id: 9555:MOB3B
uniprot id: A0A096P1E3
names: Similarity
messages: Belongs to the MOB1/phocein family.

9555:MICOS13
gene id: 9555:MICOS13
uniprot id: A0A0A0MVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9555:MCM2
gene id: 9555:MCM2
uniprot id: A0A2I3NGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9555:B3GALNT2
gene id: 9555:B3GALNT2
uniprot id: A0A096MSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:LHFPL1
gene id: 9555:LHFPL1
uniprot id: A0A096NBS0
uniprot id: A0A2I3MY47
names: Subcellular Location Annotation
messages: Membrane

9555:YWHAB
gene id: 9555:YWHAB
uniprot id: A0A096NX85
names: Similarity
messages: Belongs to the 14-3-3 family.

9555:MPO
gene id: 9555:MPO
uniprot id: A0A096P4T2
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9555:KCNG1
gene id: 9555:KCNG1
uniprot id: A0A096NNN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:RUNX1
gene id: 9555:RUNX1
uniprot id: A0A096NJ75
uniprot id: A0A2I3LQ88
uniprot id: A0A2I3MEK8
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9555:KIF3B
gene id: 9555:KIF3B
uniprot id: A0A096NUY3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:NCOA3
gene id: 9555:NCOA3
uniprot id: A0A096NSD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9555:BBOX1
gene id: 9555:BBOX1
uniprot id: A0A8I5N7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9555:CATSPER3
gene id: 9555:CATSPER3
uniprot id: A0A2I3MVR2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9555:ALKBH6
gene id: 9555:ALKBH6
uniprot id: A0A0A0MVF5
names: Similarity
messages: Belongs to the alkB family.

9555:PAX4
gene id: 9555:PAX4
uniprot id: A9RA81
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:SPRY2
gene id: 9555:SPRY2
uniprot id: A0A096N5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

9555:SIX5
gene id: 9555:SIX5
uniprot id: A0A0A0MXG2
names: Subcellular Location Annotation
messages: Nucleus

9555:NSUN5
gene id: 9555:NSUN5
uniprot id: A0A096MVF3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9555:CDC42SE2
gene id: 9555:CDC42SE2
uniprot id: A0A096MTW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9555:NCOA7
gene id: 9555:NCOA7
uniprot id: A0A096NCE5
names: Similarity
messages: Belongs to the OXR1 family.

9555:ATG9B
gene id: 9555:ATG9B
uniprot id: A0A096NRL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9555:DNPEP
gene id: 9555:DNPEP
uniprot id: B0CM48
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9555:HTR6
gene id: 9555:HTR6
uniprot id: A0A096NAV7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:RPS6KA6
gene id: 9555:RPS6KA6
uniprot id: A0A096N856
uniprot id: A0A2I3N163
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9555:PC
gene id: 9555:PC
uniprot id: A0A096NB43
uniprot id: A0A2I3LY95
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9555:PDE4B
gene id: 9555:PDE4B
uniprot id: A0A2I3MDK2
uniprot id: A0A2I3MV05
uniprot id: A0A2I3ND40
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:CPSF4
gene id: 9555:CPSF4
uniprot id: A0A096N5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9555:METAP1D
gene id: 9555:METAP1D
uniprot id: A0A096NZJ2
uniprot id: A0A2I3N0Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9555:SLC30A10
gene id: 9555:SLC30A10
uniprot id: A0A096N3H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9555:GNL2
gene id: 9555:GNL2
uniprot id: A0A096N3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9555:MMP25
gene id: 9555:MMP25
uniprot id: A0A096NLA4
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:IDH3G
gene id: 9555:IDH3G
uniprot id: A0A2I3MSB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9555:SERPINA1
gene id: 9555:SERPINA1
uniprot id: A0A096NJJ1
uniprot id: A0A2I3MI08
names: Similarity
messages: Belongs to the serpin family.

9555:EPCAM
gene id: 9555:EPCAM
uniprot id: A0A2I3M3Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9555:TMEM200C
gene id: 9555:TMEM200C
uniprot id: A0A096MUW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9555:NTHL1
gene id: 9555:NTHL1
uniprot id: A0A096NL04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9555:NR1H4
gene id: 9555:NR1H4
uniprot id: A0A096NC34
uniprot id: A0A2I3MZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:ETFB
gene id: 9555:ETFB
uniprot id: A0A0A0MWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9555:CUZD1
gene id: 9555:CUZD1
uniprot id: A0A096NU24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:BZW1
gene id: 9555:BZW1
uniprot id: A0A2I3MTU4
uniprot id: A0A8I5NJ78
names: Similarity
messages: Belongs to the BZW family.

9555:HSPB1
gene id: 9555:HSPB1
uniprot id: A0A096NWZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9555:FZD6
gene id: 9555:FZD6
uniprot id: A0A096P0Y9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:NUP133
gene id: 9555:NUP133
uniprot id: A0A096NXJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9555:TGFB2
gene id: 9555:TGFB2
uniprot id: A0A096ML01
uniprot id: A0A096MY44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9555:MFGE8
gene id: 9555:MFGE8
uniprot id: A0A096NN57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PNLDC1
gene id: 9555:PNLDC1
uniprot id: A0A096NZS6
uniprot id: A0A8I5N2P2
uniprot id: A0A8I5R180
names: Similarity
messages: Belongs to the CAF1 family.

9555:MTO1
gene id: 9555:MTO1
uniprot id: A9X188
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9555:GSC
gene id: 9555:GSC
uniprot id: A0A096NJK6
names: Subcellular Location Annotation
messages: Nucleus

9555:KPNA6
gene id: 9555:KPNA6
uniprot id: A0A2I3LJG3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9555:PPP1R35
gene id: 9555:PPP1R35
uniprot id: A0A096N5S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9555:CCN3
gene id: 9555:CCN3
uniprot id: A0A096MUT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:CHST6
gene id: 9555:CHST6
uniprot id: A0A096N7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9555:HOMER2
gene id: 9555:HOMER2
uniprot id: A0A096NN09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9555:VNN2
gene id: 9555:VNN2
uniprot id: A0A096MVC3
uniprot id: A0A2I3MC30
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9555:NEFL
gene id: 9555:NEFL
uniprot id: A0A096NG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9555:XPO4
gene id: 9555:XPO4
uniprot id: A0A096NZ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9555:TNFSF13
gene id: 9555:TNFSF13
uniprot id: A0A2I3MSE6
uniprot id: A0A2I3NAJ9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:UCK2
gene id: 9555:UCK2
uniprot id: A0A096N0S5
uniprot id: A0A8I5R0V9
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9555:MRPL3
gene id: 9555:MRPL3
uniprot id: A0A096MVU3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9555:NDUFAF2
gene id: 9555:NDUFAF2
uniprot id: A0A096MVZ2
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9555:PMEPA1
gene id: 9555:PMEPA1
uniprot id: A0A8I5QZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9555:ATP5C1
gene id: 9555:ATP5C1
uniprot id: B0CM39
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9555:HOXC6
gene id: 9555:HOXC6
uniprot id: A0A2I3MZ73
names: Subcellular Location Annotation
messages: Nucleus

9555:ADH7
gene id: 9555:ADH7
uniprot id: A0A096NPS7
uniprot id: A0A0A1EFV2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9555:CSF2
gene id: 9555:CSF2
uniprot id: Q865Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9555:UNC5C
gene id: 9555:UNC5C
uniprot id: A0A2I3NH77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9555:DIP2A
gene id: 9555:DIP2A
uniprot id: A0A096NI71
names: Similarity
messages: Belongs to the DIP2 family.

9555:TGM1
gene id: 9555:TGM1
uniprot id: A0A096NXA7
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9555:NMUR1
gene id: 9555:NMUR1
uniprot id: A0A2I3M558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9555:CPD
gene id: 9555:CPD
uniprot id: A0A096P3M5
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:GADD45G
gene id: 9555:GADD45G
uniprot id: A0A8I5R126
names: Similarity
messages: Belongs to the GADD45 family.

9555:EXT1
gene id: 9555:EXT1
uniprot id: A9X1C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
messages: Golgi apparatus membrane
messages: cis-Golgi network membrane

9555:RRP12
gene id: 9555:RRP12
uniprot id: A0A096P5Z8
names: Similarity
messages: Belongs to the RRP12 family.

9555:RAB33A
gene id: 9555:RAB33A
uniprot id: A0A096NAK1
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9555:NR2C1
gene id: 9555:NR2C1
uniprot id: A0A096N0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:TM2D3
gene id: 9555:TM2D3
uniprot id: A0A096NNG7
uniprot id: A0A2I3MGP7
names: Subcellular Location Annotation
messages: Membrane

9555:CCND1
gene id: 9555:CCND1
uniprot id: A0A8I5NW05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9555:SLC25A16
gene id: 9555:SLC25A16
uniprot id: A0A096P522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:VIPR1
gene id: 9555:VIPR1
uniprot id: A0A096MT91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9555:ACSL1
gene id: 9555:ACSL1
uniprot id: A0A096MMA5
uniprot id: A0A2I3MQU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9555:FGFR1OP2
gene id: 9555:FGFR1OP2
uniprot id: A0A096MWG9
uniprot id: A0A2I3MR60
names: Similarity
messages: Belongs to the SIKE family.

9555:LOC101022585
gene id: 9555:LOC101022585
uniprot id: A0A096P3A4
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9555:SCN5A
gene id: 9555:SCN5A
uniprot id: A0A096N0M0
uniprot id: A0A2I3MTC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9555:TIGD7
gene id: 9555:TIGD7
uniprot id: A0A096NLB6
names: Subcellular Location Annotation
messages: Nucleus

9555:MALL
gene id: 9555:MALL
uniprot id: A0A8I5MXR2
names: Subcellular Location Annotation
messages: Membrane

9555:STX19
gene id: 9555:STX19
uniprot id: A0A096N2P2
names: Similarity
messages: Belongs to the syntaxin family.

9555:ASF1B
gene id: 9555:ASF1B
uniprot id: A0A2I3M8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9555:LOC101008229
gene id: 9555:LOC101008229
uniprot id: A0A096NZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9555:MRPS6
gene id: 9555:MRPS6
uniprot id: A0A8I5NH44
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

9555:GRB14
gene id: 9555:GRB14
uniprot id: A0A096MTV0
uniprot id: A0A2I3MS20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9555:CENPH
gene id: 9555:CENPH
uniprot id: A0A2I3MDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9555:TET3
gene id: 9555:TET3
uniprot id: A0A096NFM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9555:ATF7IP
gene id: 9555:ATF7IP
uniprot id: A0A096MXV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9555:ENTPD2
gene id: 9555:ENTPD2
uniprot id: A0A096NWP8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9555:LOC101018174
gene id: 9555:LOC101018174
uniprot id: A0A096N7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LOC100998166
gene id: 9555:LOC100998166
uniprot id: A0A096NYD3
names: Subcellular Location Annotation
messages: Membrane

9555:HNRNPK
gene id: 9555:HNRNPK
uniprot id: A0A2I3LSM4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9555:LYPLAL1
gene id: 9555:LYPLAL1
uniprot id: A0A096MMW1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9555:OCRL
gene id: 9555:OCRL
uniprot id: A0A096MP77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9555:GPD2
gene id: 9555:GPD2
uniprot id: A0A8I5NQ91
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9555:SPDYA
gene id: 9555:SPDYA
uniprot id: A0A096P0B0
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9555:ODR4
gene id: 9555:ODR4
uniprot id: A0A2I3NFP3
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9555:DUSP27
gene id: 9555:DUSP27
uniprot id: A0A096N6M5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:TNFSF4
gene id: 9555:TNFSF4
uniprot id: A0A2I3LZ24
uniprot id: A0A8I5NUY7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:CHD8
gene id: 9555:CHD8
uniprot id: A0A096NNR1
uniprot id: A0A2I3N322
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9555:TFB2M
gene id: 9555:TFB2M
uniprot id: A0A8I5R6P9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9555:MCM10
gene id: 9555:MCM10
uniprot id: A0A096P3G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

9555:PTPN1
gene id: 9555:PTPN1
uniprot id: A0A096NNQ0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9555:MEIS2
gene id: 9555:MEIS2
uniprot id: A0A2I3N0R6
uniprot id: A0A2I3N8K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9555:ACRBP
gene id: 9555:ACRBP
uniprot id: A0A096N1X4
names: Subcellular Location Annotation
messages: acrosome

9555:CYFIP2
gene id: 9555:CYFIP2
uniprot id: A0A096NBB1
uniprot id: A0A2I3MQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9555:RNFT2
gene id: 9555:RNFT2
uniprot id: A0A096NC27
names: Subcellular Location Annotation
messages: Membrane

9555:GPT2
gene id: 9555:GPT2
uniprot id: A0A2I3M4W3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9555:TMOD4
gene id: 9555:TMOD4
uniprot id: A9X195
names: Subcellular Location Annotation
messages: cytoskeleton

9555:LOC101020272
gene id: 9555:LOC101020272
uniprot id: A0A096NB70
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:YIPF2
gene id: 9555:YIPF2
uniprot id: A0A0A0MXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9555:ETFDH
gene id: 9555:ETFDH
uniprot id: A0A2I3LQT4
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9555:FLNA
gene id: 9555:FLNA
uniprot id: A9CB59
names: Similarity
messages: Belongs to the filamin family.

9555:SLC30A6
gene id: 9555:SLC30A6
uniprot id: A0A096NFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9555:NKAIN2
gene id: 9555:NKAIN2
uniprot id: A0A096NCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9555:SLC16A7
gene id: 9555:SLC16A7
uniprot id: A0A096MKY8
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9555:UQCC
gene id: 9555:UQCC
uniprot id: B0CM77
names: Similarity
messages: Belongs to the CBP3 family.

9555:MRPL16
gene id: 9555:MRPL16
uniprot id: A0A096N4R1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9555:MFRP
gene id: 9555:MFRP
uniprot id: A0A096N3G3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TMED2
gene id: 9555:TMED2
uniprot id: A0A096NBB9
uniprot id: A0A2I3LEI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9555:OLFR633
gene id: 9555:OLFR633
uniprot id: A9L8Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:LOC100997503
gene id: 9555:LOC100997503
uniprot id: A0A2I3NEC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9555:OTX1
gene id: 9555:OTX1
uniprot id: A0A8I5NC04
names: Subcellular Location Annotation
messages: Nucleus

9555:KCTD10
gene id: 9555:KCTD10
uniprot id: A0A096MXR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9555:CA4
gene id: 9555:CA4
uniprot id: A0A096P503
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

9555:RANBP17
gene id: 9555:RANBP17
uniprot id: A0A096N441
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9555:PHKB
gene id: 9555:PHKB
uniprot id: A0A2I3LIY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9555:OR51S1
gene id: 9555:OR51S1
uniprot id: A9L8V8
names: Subcellular Location Annotation
messages: Membrane

9555:MTFP1
gene id: 9555:MTFP1
uniprot id: A0A2I3M1H3
names: Similarity
messages: Belongs to the MTFP1 family.

9555:SPON1
gene id: 9555:SPON1
uniprot id: A0A096N2S9
names: Subcellular Location Annotation
messages: extracellular matrix

9555:VANGL1
gene id: 9555:VANGL1
uniprot id: A0A096N7W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9555:MED29
gene id: 9555:MED29
uniprot id: A0A0A0MV48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9555:TEKT4
gene id: 9555:TEKT4
uniprot id: A0A096P258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9555:FAM83C
gene id: 9555:FAM83C
uniprot id: A0A096NUP9
names: Similarity
messages: Belongs to the FAM83 family.

9555:AVL9
gene id: 9555:AVL9
uniprot id: A0A096P049
uniprot id: A0A2I3LYU5
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9555:EIF4E2
gene id: 9555:EIF4E2
uniprot id: A0A096N2E7
uniprot id: A0A096N7Z8
uniprot id: A0A2I3MEE8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9555:RNF13
gene id: 9555:RNF13
uniprot id: A0A096MS08
names: Subcellular Location Annotation
messages: Membrane

9555:ISCU
gene id: 9555:ISCU
uniprot id: A0A2I3LZQ8
uniprot id: A0A2I3M445
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9555:CDC14B
gene id: 9555:CDC14B
uniprot id: A0A2I3M7K0
uniprot id: A0A2I3MUA9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9555:TOX4
gene id: 9555:TOX4
uniprot id: A0A096NNR6
names: Subcellular Location Annotation
messages: Nucleus

9555:KARS1
gene id: 9555:KARS1
uniprot id: A0A2I3M3H5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9555:PIK3C2G
gene id: 9555:PIK3C2G
uniprot id: A0A096N515
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9555:RIC3
gene id: 9555:RIC3
uniprot id: A0A096N4F8
names: Similarity
messages: Belongs to the ric-3 family.

9555:LHCGR
gene id: 9555:LHCGR
uniprot id: A0A096MZQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9555:HMGCLL1
gene id: 9555:HMGCLL1
uniprot id: A0A096NJC5
uniprot id: A0A2I3NHM1
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9555:CALCA
gene id: 9555:CALCA
uniprot id: A0A096MYB1
uniprot id: A0A096NGD0
names: Similarity
messages: Belongs to the calcitonin family.

9555:CA8
gene id: 9555:CA8
uniprot id: A0A096MSS8
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9555:LOC101010936
gene id: 9555:LOC101010936
uniprot id: A0A8I5N4T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:NIM1K
gene id: 9555:NIM1K
uniprot id: A0A096NP15
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CBR3
gene id: 9555:CBR3
uniprot id: A0A096NJ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9555:NKX1-2
gene id: 9555:NKX1-2
uniprot id: A0A096NU56
names: Subcellular Location Annotation
messages: Nucleus

9555:FZD4
gene id: 9555:FZD4
uniprot id: A0A096MVT8
uniprot id: A0A8I5MWG7
uniprot id: A0A8I5MYT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9555:MMP15
gene id: 9555:MMP15
uniprot id: A0A096NIY8
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:DENND10
gene id: 9555:DENND10
uniprot id: A0A096NTX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9555:SNAP25
gene id: 9555:SNAP25
uniprot id: A0A096NVI2
uniprot id: A0A2I3MH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9555:FGD3
gene id: 9555:FGD3
uniprot id: A0A096P242
names: Subcellular Location Annotation
messages: cytoskeleton

9555:C9H12orf49
gene id: 9555:C9H12orf49
uniprot id: A0A096MVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9555:GNG7
gene id: 9555:GNG7
uniprot id: A0A0A0MW42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9555:TCTEX1D4
gene id: 9555:TCTEX1D4
uniprot id: A0A8I5NBU8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9555:PFKM
gene id: 9555:PFKM
uniprot id: A0A096N5N7
uniprot id: A0A8I5NCT7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:RSPH3
gene id: 9555:RSPH3
uniprot id: B0CM43
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

9555:PTPN4
gene id: 9555:PTPN4
uniprot id: A0A096MX43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9555:ABITRAM
gene id: 9555:ABITRAM
uniprot id: A0A096P0Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9555:KIAA2013
gene id: 9555:KIAA2013
uniprot id: A0A096N937
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101003561
gene id: 9555:LOC101003561
uniprot id: A0A096N4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SRD5A1
gene id: 9555:SRD5A1
uniprot id: A0A096NCN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

9555:CD28
gene id: 9555:CD28
uniprot id: A0A2I3N9H4
uniprot id: Q9BDN8
names: Subcellular Location Annotation
messages: Membrane

9555:TMEM175
gene id: 9555:TMEM175
uniprot id: A0A2I3NHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9555:SLC6A14
gene id: 9555:SLC6A14
uniprot id: A0A096MXM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9555:PGF
gene id: 9555:PGF
uniprot id: A0A096NQB0
uniprot id: A0A2I3MWB0
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9555:TFR2
gene id: 9555:TFR2
uniprot id: A0A096NRN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9555:ZNF280C
gene id: 9555:ZNF280C
uniprot id: A0A096N4X0
uniprot id: A0A2I3LW69
uniprot id: A0A8I5NCG2
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9555:NEK6
gene id: 9555:NEK6
uniprot id: A0A2I3MHL3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:DENR
gene id: 9555:DENR
uniprot id: A0A2I3MMQ2
names: Similarity
messages: Belongs to the DENR family.

9555:MSRA
gene id: 9555:MSRA
uniprot id: A0A096N895
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9555:UBE2F
gene id: 9555:UBE2F
uniprot id: A0A096N971
uniprot id: A0A2I3MGC6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:SPC24
gene id: 9555:SPC24
uniprot id: A0A0A0MUP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9555:PYGB
gene id: 9555:PYGB
uniprot id: A0A096NVV1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9555:DCTN6
gene id: 9555:DCTN6
uniprot id: A0A2I3LT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9555:VDAC3
gene id: 9555:VDAC3
uniprot id: A0A2I3MAG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9555:LOC101016808
gene id: 9555:LOC101016808
uniprot id: A0A096MNS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ABRAXAS2
gene id: 9555:ABRAXAS2
uniprot id: A0A096NU61
names: Subcellular Location Annotation
messages: Nucleus

9555:SPOPL
gene id: 9555:SPOPL
uniprot id: A0A096N9F4
names: Similarity
messages: Belongs to the Tdpoz family.

9555:GNAZ
gene id: 9555:GNAZ
uniprot id: A0A096NRB0
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9555:BRPF1
gene id: 9555:BRPF1
uniprot id: A0A096NGL6
uniprot id: A0A2I3LLR5
uniprot id: A0A2I3LZ95
names: Subcellular Location Annotation
messages: Nucleus

9555:SERF1A
gene id: 9555:SERF1A
uniprot id: A0A2I3MJ79
names: Similarity
messages: Belongs to the SERF family.

9555:RGS1
gene id: 9555:RGS1
uniprot id: A0A8I5NDA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9555:CHST4
gene id: 9555:CHST4
uniprot id: A0A096MUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9555:ARG2
gene id: 9555:ARG2
uniprot id: A0A096NVQ1
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9555:IL3
gene id: 9555:IL3
uniprot id: A9CB22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

9555:PACSIN2
gene id: 9555:PACSIN2
uniprot id: A0A096NKG3
uniprot id: A0A2I3NEA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9555:SLC12A3
gene id: 9555:SLC12A3
uniprot id: A0A096NIM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9555:LOC101016760
gene id: 9555:LOC101016760
uniprot id: A0A2I3MS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9555:UBE2D1
gene id: 9555:UBE2D1
uniprot id: A0A096P578
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:LOC101009930
gene id: 9555:LOC101009930
uniprot id: A0A8I5N7X0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9555:CXHXorf56
gene id: 9555:CXHXorf56
uniprot id: A0A096MNT2
names: Similarity
messages: Belongs to the STEEP1 family.

9555:GPR37
gene id: 9555:GPR37
uniprot id: A0A8I5R605
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:MAPRE2
gene id: 9555:MAPRE2
uniprot id: A0A096N3K2
uniprot id: A0A2I3MCT2
uniprot id: A0A2I3N9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

9555:DHRS7B
gene id: 9555:DHRS7B
uniprot id: A0A096P358
uniprot id: A0A2I3LIZ0
uniprot id: A0A2I3LW45
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:PNPO
gene id: 9555:PNPO
uniprot id: A0A096P410
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9555:SMIM7
gene id: 9555:SMIM7
uniprot id: A0A8I5R0I9
names: Similarity
messages: Belongs to the SMIM7 family.

9555:SEC23A
gene id: 9555:SEC23A
uniprot id: A0A096NUP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9555:B9D1
gene id: 9555:B9D1
uniprot id: A0A2I3MTN3
names: Subcellular Location Annotation
messages: cilium basal body

9555:ODF1
gene id: 9555:ODF1
uniprot id: A0A096NQB7
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9555:ZNF503
gene id: 9555:ZNF503
uniprot id: A0A096P4I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9555:GNB1
gene id: 9555:GNB1
uniprot id: A0A096N6G8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9555:DDX5
gene id: 9555:DDX5
uniprot id: A0A2I3LR70
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9555:IMPDH1
gene id: 9555:IMPDH1
uniprot id: A0A2I3N1L1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9555:TSG101
gene id: 9555:TSG101
uniprot id: A0A2I3N4L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

9555:CPB2
gene id: 9555:CPB2
uniprot id: A0A096NA31
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:MRPS26
gene id: 9555:MRPS26
uniprot id: A0A096NV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9555:C5H5orf22
gene id: 9555:C5H5orf22
uniprot id: A0A096N4A5
names: Similarity
messages: Belongs to the UPF0489 family.

9555:BUD13
gene id: 9555:BUD13
uniprot id: A9CB26
names: Similarity
messages: Belongs to the CWC26 family.

9555:ISY1
gene id: 9555:ISY1
uniprot id: A0A096MPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9555:ST3GAL5
gene id: 9555:ST3GAL5
uniprot id: A0A096NZW4
uniprot id: A0A2I3NDP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:SH3RF1
gene id: 9555:SH3RF1
uniprot id: A0A096NFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9555:CMTM6
gene id: 9555:CMTM6
uniprot id: A0A096NH48
names: Subcellular Location Annotation
messages: Membrane

9555:FAM219A
gene id: 9555:FAM219A
uniprot id: A0A096P1B2
names: Similarity
messages: Belongs to the FAM219 family.

9555:CDK14
gene id: 9555:CDK14
uniprot id: A0A096NZU3
uniprot id: A0A2I3LX48
uniprot id: B0CM29
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:AFAP1L1
gene id: 9555:AFAP1L1
uniprot id: A0A096MTS5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

9555:CACNG6
gene id: 9555:CACNG6
uniprot id: A0A0A0MUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9555:GRN
gene id: 9555:GRN
uniprot id: A0A096P615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9555:MAPK14
gene id: 9555:MAPK14
uniprot id: A0A096NHR3
uniprot id: A0A2I3LNN6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9555:GABRG1
gene id: 9555:GABRG1
uniprot id: A0A096NZ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:INO80C
gene id: 9555:INO80C
uniprot id: A0A2I3LDX8
uniprot id: A0A2I3N7R0
names: Subcellular Location Annotation
messages: Nucleus

9555:AKAP8
gene id: 9555:AKAP8
uniprot id: A0A0A0MW70
names: Similarity
messages: Belongs to the AKAP95 family.

9555:MSTN
gene id: 9555:MSTN
uniprot id: A0A096NPW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9555:SGTB
gene id: 9555:SGTB
uniprot id: A0A096MW67
names: Similarity
messages: Belongs to the SGT family.

9555:LOC100997115
gene id: 9555:LOC100997115
uniprot id: A0A096NEX4
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9555:ILDR1
gene id: 9555:ILDR1
uniprot id: A0A096N9E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9555:CHPT1
gene id: 9555:CHPT1
uniprot id: A0A096NE05
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9555:AQP7
gene id: 9555:AQP7
uniprot id: A0A096P1C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9555:NPC1
gene id: 9555:NPC1
uniprot id: A0A096MSL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9555:PLAG1
gene id: 9555:PLAG1
uniprot id: A0A096NEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9555:BB R133 JSM474C8F
gene id: 9555:BB_R133_JSM474C8F
uniprot id: B0CM31
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9555:IL1RL1
gene id: 9555:IL1RL1
uniprot id: A0A096MQK8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9555:LUC7L3
gene id: 9555:LUC7L3
uniprot id: A0A096P4L3
uniprot id: A0A096P4L4
names: Similarity
messages: Belongs to the Luc7 family.

9555:SATB1
gene id: 9555:SATB1
uniprot id: A0A096N6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9555:LOC101024162
gene id: 9555:LOC101024162
uniprot id: A0A096NSK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9555:HTR5A
gene id: 9555:HTR5A
uniprot id: A0A096NZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TASP1
gene id: 9555:TASP1
uniprot id: A0A096NVJ6
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9555:PSMB5
gene id: 9555:PSMB5
uniprot id: A0A096NRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:LOC101022429
gene id: 9555:LOC101022429
uniprot id: A0A096N7S1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9555:PMM2
gene id: 9555:PMM2
uniprot id: A0A096NLL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9555:HNRNPF
gene id: 9555:HNRNPF
uniprot id: A0A096ND72
names: Subcellular Location Annotation
messages: nucleoplasm

9555:COX1
gene id: 9555:COX1
uniprot id: K9MVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9555:NAPG
gene id: 9555:NAPG
uniprot id: A0A2I3M579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9555:CDH13
gene id: 9555:CDH13
uniprot id: A0A096NWW3
uniprot id: A0A2I3MEP1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

9555:RGS9BP
gene id: 9555:RGS9BP
uniprot id: A0A0A0MVM2
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9555:RALA
gene id: 9555:RALA
uniprot id: A0A096NQV3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9555:DRC7
gene id: 9555:DRC7
uniprot id: A0A096NIV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9555:RBFOX2
gene id: 9555:RBFOX2
uniprot id: A0A096NJS9
names: Subcellular Location Annotation
messages: Nucleus

9555:SLC9A3R2
gene id: 9555:SLC9A3R2
uniprot id: A0A096NL00
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9555:NIF3L1
gene id: 9555:NIF3L1
uniprot id: A0A096N0A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9555:WDR91
gene id: 9555:WDR91
uniprot id: A0A2I3M9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:MRPS24
gene id: 9555:MRPS24
uniprot id: A0A096NZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9555:CPT1C
gene id: 9555:CPT1C
uniprot id: A0A0A0MWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:LMLN
gene id: 9555:LMLN
uniprot id: A0A096P1C6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9555:XPNPEP2
gene id: 9555:XPNPEP2
uniprot id: A0A096NC77
names: Similarity
messages: Belongs to the peptidase M24B family.

9555:ANKRD13B
gene id: 9555:ANKRD13B
uniprot id: A0A096P3K4
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9555:SLC35F1
gene id: 9555:SLC35F1
uniprot id: A0A2I3LYP4
uniprot id: A0A8I5NM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9555:OTOP3
gene id: 9555:OTOP3
uniprot id: A0A096NSS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9555:LOC100997976
gene id: 9555:LOC100997976
uniprot id: A0A2I3M5Q6
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9555:L3MBTL2
gene id: 9555:L3MBTL2
uniprot id: A0A096NKA0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9555:TRAPPC2L
gene id: 9555:TRAPPC2L
uniprot id: A0A096NFG2
uniprot id: A0A8I5ND35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9555:KLHL21
gene id: 9555:KLHL21
uniprot id: A0A096NDF5
names: Subcellular Location Annotation
messages: spindle

9555:HOXA10
gene id: 9555:HOXA10
uniprot id: A9L943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9555:RPL6
gene id: 9555:RPL6
uniprot id: A0A096N393
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9555:UBE2E1
gene id: 9555:UBE2E1
uniprot id: A0A2I3M7H8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:POU5F1
gene id: 9555:POU5F1
uniprot id: A0A096NJD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9555:FEZ2
gene id: 9555:FEZ2
uniprot id: A0A096NR55
uniprot id: A0A2I3MTL6
uniprot id: A0A8I5R0F0
names: Similarity
messages: Belongs to the zygin family.

9555:TIMM23
gene id: 9555:TIMM23
uniprot id: A0A096P495
uniprot id: A0A2I3N5I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9555:GTF2H5
gene id: 9555:GTF2H5
uniprot id: A0A8I5NN96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9555:OSTC
gene id: 9555:OSTC
uniprot id: A0A096MQY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9555:RDH5
gene id: 9555:RDH5
uniprot id: A0A096NGJ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:GPAT4
gene id: 9555:GPAT4
uniprot id: A0A096N0N6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9555:CFAP43
gene id: 9555:CFAP43
uniprot id: A0A096P6I3
names: Similarity
messages: Belongs to the CFAP43 family.

9555:TSEN2
gene id: 9555:TSEN2
uniprot id: A0A096NYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9555:NR2F2
gene id: 9555:NR2F2
uniprot id: A0A2I3N4Z0
uniprot id: A0A2I3N666
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:PRPF19
gene id: 9555:PRPF19
uniprot id: A0A096MKP8
uniprot id: A0A2I3LU32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9555:GTPBP10
gene id: 9555:GTPBP10
uniprot id: B0CM27
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9555:FITM1
gene id: 9555:FITM1
uniprot id: A0A096NX71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9555:TAF7
gene id: 9555:TAF7
uniprot id: A0A8I5NME3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9555:SPPL3
gene id: 9555:SPPL3
uniprot id: A0A096MYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9555:NADSYN1
gene id: 9555:NADSYN1
uniprot id: A0A096MPW7
names: Similarity
names: Subunit
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

9555:LRRC42
gene id: 9555:LRRC42
uniprot id: A0A096NY66
names: Similarity
messages: Belongs to the LRRC42 family.

9555:GATA2
gene id: 9555:GATA2
uniprot id: A0A096N3W4
names: Subcellular Location Annotation
messages: Nucleus

9555:MAPRE1
gene id: 9555:MAPRE1
uniprot id: A0A096NUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9555:LOC101022294
gene id: 9555:LOC101022294
uniprot id: A0A096NFZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:COPS7A
gene id: 9555:COPS7A
uniprot id: A0A096N053
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9555:PLPPR1
gene id: 9555:PLPPR1
uniprot id: A0A2I3M943
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9555:UGT3A2
gene id: 9555:UGT3A2
uniprot id: A0A2I3LVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:SGO2
gene id: 9555:SGO2
uniprot id: A0A096MQN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9555:CCS
gene id: 9555:CCS
uniprot id: A0A096MMD2
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9555:PYGL
gene id: 9555:PYGL
uniprot id: A0A096NUY6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9555:ZEB1
gene id: 9555:ZEB1
uniprot id: A0A096P409
uniprot id: A0A2I3LM14
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9555:PTH2
gene id: 9555:PTH2
uniprot id: A0A0A0MVF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

9555:CDK5R1
gene id: 9555:CDK5R1
uniprot id: A0A096NC49
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9555:SYF2
gene id: 9555:SYF2
uniprot id: A0A096NS30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9555:BTN2A2
gene id: 9555:BTN2A2
uniprot id: A0A096NLH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9555:SLC26A2
gene id: 9555:SLC26A2
uniprot id: A0A096MRQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9555:NR2C2
gene id: 9555:NR2C2
uniprot id: A0A2I3LFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:ST3GAL1
gene id: 9555:ST3GAL1
uniprot id: A0A096MSS2
uniprot id: A0A2I3MRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:PGPEP1
gene id: 9555:PGPEP1
uniprot id: A0A0A0MW47
uniprot id: A0A2I3LDJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9555:XKR9
gene id: 9555:XKR9
uniprot id: A0A8I5NTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9555:KRT1
gene id: 9555:KRT1
uniprot id: A0A096NAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:MGRN1
gene id: 9555:MGRN1
uniprot id: A0A096NLF7
uniprot id: A0A2I3LJT9
uniprot id: A0A2I3NA61
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9555:SCFD2
gene id: 9555:SCFD2
uniprot id: A0A2I3MVU5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9555:MEP1A
gene id: 9555:MEP1A
uniprot id: A0A096NIV6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ESD
gene id: 9555:ESD
uniprot id: A0A096MM92
uniprot id: A0A8I5NZP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9555:TAP1
gene id: 9555:TAP1
uniprot id: A0A096NHE3
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9555:ACTR1B
gene id: 9555:ACTR1B
uniprot id: A0A096NGT7
names: Similarity
messages: Belongs to the actin family.

9555:ELK3
gene id: 9555:ELK3
uniprot id: A0A096MM75
uniprot id: A0A8I5N934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:COPB1
gene id: 9555:COPB1
uniprot id: A0A096NEA3
uniprot id: A0A8I5RA07
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9555:GALNT5
gene id: 9555:GALNT5
uniprot id: A0A096NCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:ACSF2
gene id: 9555:ACSF2
uniprot id: A0A096P4I6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:ITPKA
gene id: 9555:ITPKA
uniprot id: A0A096NTN1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:LOC101005596
gene id: 9555:LOC101005596
uniprot id: A0A0A0MXL2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:ADCYAP1R1
gene id: 9555:ADCYAP1R1
uniprot id: A0A2I3LT46
uniprot id: A0A2I3LYH2
uniprot id: A0A2I3N5Q0
names: Subcellular Location Annotation
messages: Membrane

9555:SLC66A2
gene id: 9555:SLC66A2
uniprot id: A0A096N955
uniprot id: A0A2I3LF97
uniprot id: A0A8I5N599
names: Subcellular Location Annotation
messages: Membrane

9555:CLIC6
gene id: 9555:CLIC6
uniprot id: A0A096NJ77
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9555:LOC103878831
gene id: 9555:LOC103878831
uniprot id: A0A096MZY1
names: Subunit
messages: Interacts with hair keratins.

9555:TPM1
gene id: 9555:TPM1
uniprot id: A0A096NMA0
uniprot id: A0A2I3LSV9
uniprot id: A0A2I3MCI7
uniprot id: A0A2I3MED4
uniprot id: A0A2I3MNH6
uniprot id: A0A2I3N825
uniprot id: A0A2I3NER8
uniprot id: A0A2I3NGQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9555:USP24
gene id: 9555:USP24
uniprot id: A0A096MXK2
uniprot id: A0A096NA37
names: Similarity
messages: Belongs to the peptidase C19 family.

9555:SLITRK5
gene id: 9555:SLITRK5
uniprot id: A0A096N0C7
names: Similarity
messages: Belongs to the SLITRK family.

9555:GTF2H3
gene id: 9555:GTF2H3
uniprot id: A0A2I3NDJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9555:COG3
gene id: 9555:COG3
uniprot id: A0A096MRW7
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9555:TOLLIP
gene id: 9555:TOLLIP
uniprot id: A0A096MQQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9555:MICALL1
gene id: 9555:MICALL1
uniprot id: A0A096NJZ8
names: Subcellular Location Annotation
messages: Membrane

9555:ANXA13
gene id: 9555:ANXA13
uniprot id: A0A096N2Z4
uniprot id: A0A2I3MKG4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9555:SMAD3
gene id: 9555:SMAD3
uniprot id: A0A096NMF6
uniprot id: A0A8I5NQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9555:HSDL2
gene id: 9555:HSDL2
uniprot id: A0A096P0V4
names: Subcellular Location Annotation
messages: Peroxisome

9555:ADCY9
gene id: 9555:ADCY9
uniprot id: A0A096NLD9
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9555:TCF7L1
gene id: 9555:TCF7L1
uniprot id: A0A096MTR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9555:CHD6
gene id: 9555:CHD6
uniprot id: A0A096NXC8
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9555:DPPA5
gene id: 9555:DPPA5
uniprot id: A0A096N367
uniprot id: A0A2I3LV22
names: Similarity
messages: Belongs to the KHDC1 family.

9555:ERCC3
gene id: 9555:ERCC3
uniprot id: A0A096NNZ8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9555:CPB1
gene id: 9555:CPB1
uniprot id: A0A096NP95
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:GOSR2
gene id: 9555:GOSR2
uniprot id: A0A096P674
uniprot id: A0A2I3MM60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9555:GOLT1A
gene id: 9555:GOLT1A
uniprot id: A0A096NB96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9555:SMAD1
gene id: 9555:SMAD1
uniprot id: A0A096NQS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9555:BICD1
gene id: 9555:BICD1
uniprot id: A0A096N9C7
uniprot id: A0A2I3LEN0
names: Similarity
messages: Belongs to the BicD family.

9555:RPL5
gene id: 9555:RPL5
uniprot id: A0A096N666
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9555:NPAS4
gene id: 9555:NPAS4
uniprot id: A0A2I3MYJ5
names: Subcellular Location Annotation
messages: Nucleus

9555:SHC1
gene id: 9555:SHC1
uniprot id: A0A096NAX6
names: Subcellular Location Annotation
messages: Cytoplasm

9555:CLDN18
gene id: 9555:CLDN18
uniprot id: A0A096N1K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:LOC108582545
gene id: 9555:LOC108582545
uniprot id: A0A8I5R6D0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9555:ACTL10
gene id: 9555:ACTL10
uniprot id: A0A096N915
names: Similarity
messages: Belongs to the actin family.

9555:LOC100999705
gene id: 9555:LOC100999705
uniprot id: A0A096MLU1
names: Similarity
messages: Belongs to the SPAN-X family.

9555:CHRM2
gene id: 9555:CHRM2
uniprot id: A0A096N020
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9555:EI24
gene id: 9555:EI24
uniprot id: A0A096N7K0
uniprot id: A0A2I3MS72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9555:NR5A2
gene id: 9555:NR5A2
uniprot id: A0A096NRJ5
uniprot id: A0A2I3LUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9555:MAX
gene id: 9555:MAX
uniprot id: A0A096NVM5
uniprot id: A0A2I3MV47
names: Similarity
messages: Belongs to the MAX family.

9555:TP53
gene id: 9555:TP53
uniprot id: A0A096P2R8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9555:SLC5A11
gene id: 9555:SLC5A11
uniprot id: A0A096NHH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:TXLNB
gene id: 9555:TXLNB
uniprot id: A0A8I5NJQ3
names: Similarity
messages: Belongs to the taxilin family.

9555:SHFL
gene id: 9555:SHFL
uniprot id: A0A2I3MDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body

9555:UBE2D3
gene id: 9555:UBE2D3
uniprot id: A0A2I3M270
uniprot id: A0A2I3NG84
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:ZDHHC20
gene id: 9555:ZDHHC20
uniprot id: A0A096N7D5
uniprot id: A0A2I3LYJ1
uniprot id: A0A2I3MVS5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:PROK1
gene id: 9555:PROK1
uniprot id: A0A8I5NIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9555:GUK1
gene id: 9555:GUK1
uniprot id: A0A2I3N7Y9
names: Similarity
messages: Belongs to the guanylate kinase family.

9555:ORC6
gene id: 9555:ORC6
uniprot id: A0A096NI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9555:RFX2
gene id: 9555:RFX2
uniprot id: A0A0A0MVN4
uniprot id: A0A2I3MBG1
names: Subcellular Location Annotation
messages: Nucleus

9555:LOC101022296
gene id: 9555:LOC101022296
uniprot id: A0A096MKM7
uniprot id: A0A096N9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:BTDB
gene id: 9555:BTDB
uniprot id: B6ULW5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: BTD-1 and BTD-2 have antimicrobial activity against the Gram-negative bacterium E.coli ML35, the Gram-positive bacterium S.aureus 502a, and the fungus C.albicans 16820. BTD-2 is more effective against E.coli than BTD-1.
messages: BTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. BTD-2 is a cyclic homodimer composed of two subunits B; disulfide-linked.
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic peptide with subunit A (BTD-1), or subunit B (BTD-2). An additional intersubunit disulfide bond is formed.

9555:GALNT16
gene id: 9555:GALNT16
uniprot id: A0A096NVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:RABGGTB
gene id: 9555:RABGGTB
uniprot id: A0A096P020
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9555:MAP1LC3B
gene id: 9555:MAP1LC3B
uniprot id: A0A096NS02
names: Similarity
messages: Belongs to the ATG8 family.

9555:CHL1
gene id: 9555:CHL1
uniprot id: A0A096N2A7
uniprot id: A0A2I3N6J6
uniprot id: A0A2I3NHL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9555:PLD1
gene id: 9555:PLD1
uniprot id: A0A096MMA2
uniprot id: A0A096N778
names: Similarity
messages: Belongs to the phospholipase D family.

9555:RPL19
gene id: 9555:RPL19
uniprot id: A0A096P5A3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9555:NLRP14
gene id: 9555:NLRP14
uniprot id: A0A096MSZ9
names: Similarity
messages: Belongs to the NLRP family.

9555:ZDHHC21
gene id: 9555:ZDHHC21
uniprot id: A0A8I5NRC6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:CAPZA1
gene id: 9555:CAPZA1
uniprot id: A0A096NE85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9555:FADS2
gene id: 9555:FADS2
uniprot id: B8R1K0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (PubMed:19202133).
messages: The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases.

9555:OLFML2B
gene id: 9555:OLFML2B
uniprot id: A0A096N7V9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOXL3
gene id: 9555:LOXL3
uniprot id: A0A096MVB4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9555:NELL2
gene id: 9555:NELL2
uniprot id: A0A096MZI4
uniprot id: A0A2I3M5V9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101004536
gene id: 9555:LOC101004536
uniprot id: A0A8I5NTL9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LIMK2
gene id: 9555:LIMK2
uniprot id: A0A096NJM2
uniprot id: A0A2I3LEX5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9555:CTU1
gene id: 9555:CTU1
uniprot id: A0A0A0MXD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9555:FGF5
gene id: 9555:FGF5
uniprot id: A0A096N9F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9555:BNIP1
gene id: 9555:BNIP1
uniprot id: A0A096MRU8
names: Subcellular Location Annotation
messages: Membrane

9555:B9D2
gene id: 9555:B9D2
uniprot id: A0A0A0MVF1
names: Subcellular Location Annotation
messages: cilium basal body

9555:ZFHX4
gene id: 9555:ZFHX4
uniprot id: A0A096N7P0
names: Subcellular Location Annotation
messages: Nucleus

9555:KAT2B
gene id: 9555:KAT2B
uniprot id: A0A096NY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9555:PNRC1
gene id: 9555:PNRC1
uniprot id: A0A096P094
names: Subcellular Location Annotation
messages: Nucleus

9555:YES1
gene id: 9555:YES1
uniprot id: A0A8I5P3Y0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:CSTA
gene id: 9555:CSTA
uniprot id: A0A8I5MY80
names: Similarity
messages: Belongs to the cystatin family.

9555:CNEP1R1
gene id: 9555:CNEP1R1
uniprot id: A0A096NI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9555:SCN11A
gene id: 9555:SCN11A
uniprot id: A0A096NEP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9555:ADCK1
gene id: 9555:ADCK1
uniprot id: A0A096NSA6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9555:PRPSAP2
gene id: 9555:PRPSAP2
uniprot id: A0A096P338
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9555:INSL3
gene id: 9555:INSL3
uniprot id: A0A0A0MWS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

9555:DPYSL4
gene id: 9555:DPYSL4
uniprot id: A0A096NSV5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9555:S100A4
gene id: 9555:S100A4
uniprot id: A0A096NEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9555:NRP1
gene id: 9555:NRP1
uniprot id: A0A2I3LIK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ATP5MC1
gene id: 9555:ATP5MC1
uniprot id: A0A096P441
uniprot id: A0A2I3LI66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9555:MOB1A
gene id: 9555:MOB1A
uniprot id: A0A096NXT1
names: Similarity
messages: Belongs to the MOB1/phocein family.

9555:CDK6
gene id: 9555:CDK6
uniprot id: A0A096NF27
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CHN1
gene id: 9555:CHN1
uniprot id: A0A2I3LM77
names: Function
messages: GTPase-activating protein for p21-rac.

9555:BRI3
gene id: 9555:BRI3
uniprot id: A0A096NY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

9555:GSTZ1
gene id: 9555:GSTZ1
uniprot id: A0A096NS84
uniprot id: A0A2I3MR97
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9555:KCTD20
gene id: 9555:KCTD20
uniprot id: A0A2I3LR49
names: Subcellular Location Annotation
messages: Cytoplasm

9555:SLC25A20
gene id: 9555:SLC25A20
uniprot id: A0A096NF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:SLC16A9
gene id: 9555:SLC16A9
uniprot id: A0A096P569
names: Subcellular Location Annotation
messages: Membrane

9555:ADCK2
gene id: 9555:ADCK2
uniprot id: A0A096N2B4
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9555:MRPL32
gene id: 9555:MRPL32
uniprot id: A0A096NG95
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9555:CAPRIN1
gene id: 9555:CAPRIN1
uniprot id: A0A096NSE3
names: Similarity
messages: Belongs to the caprin family.

9555:LOC101026920
gene id: 9555:LOC101026920
uniprot id: A0A8I5QZY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:STAC2
gene id: 9555:STAC2
uniprot id: A0A096P5A6
names: Subcellular Location Annotation
messages: sarcolemma

9555:LOC108587428
gene id: 9555:LOC108587428
uniprot id: A0A2I3N8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9555:DMRT1
gene id: 9555:DMRT1
uniprot id: A0A096P1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9555:NONO
gene id: 9555:NONO
uniprot id: A0A096MM00
names: Subcellular Location Annotation
messages: Nucleus speckle

9555:LOC101022884
gene id: 9555:LOC101022884
uniprot id: A0A096NFZ5
names: Similarity
messages: Belongs to the HSBP1 family.

9555:RAD23A
gene id: 9555:RAD23A
uniprot id: A0A0A0MWE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9555:QPCTL
gene id: 9555:QPCTL
uniprot id: A0A0A0MXI0
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9555:TJAP1
gene id: 9555:TJAP1
uniprot id: A0A8I5N5G6
uniprot id: A0A8I5NJN8
names: Subcellular Location Annotation
messages: Membrane

9555:CMC4
gene id: 9555:CMC4
uniprot id: A0A096ML73
names: Similarity
messages: Belongs to the CMC4 family.

9555:IRF7
gene id: 9555:IRF7
uniprot id: A0A096MQH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:INHA
gene id: 9555:INHA
uniprot id: B0CM57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9555:ATP5PB
gene id: 9555:ATP5PB
uniprot id: A0A096N2L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9555:TENT5A
gene id: 9555:TENT5A
uniprot id: A0A2I3N863
names: Similarity
messages: Belongs to the TENT family.

9555:NOB1
gene id: 9555:NOB1
uniprot id: A0A096N164
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9555:DDO
gene id: 9555:DDO
uniprot id: A0A096MS66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9555:MESD
gene id: 9555:MESD
uniprot id: A0A096NMY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9555:HYAL1
gene id: 9555:HYAL1
uniprot id: A0A096NXR1
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9555:RETNLB
gene id: 9555:RETNLB
uniprot id: A0A096MQN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9555:PFDN4
gene id: 9555:PFDN4
uniprot id: A0A2I3N630
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9555:FGF1
gene id: 9555:FGF1
uniprot id: B0CM87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9555:CD59
gene id: 9555:CD59
uniprot id: A0A8I5NBS6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

9555:CNIH1
gene id: 9555:CNIH1
uniprot id: A0A096NV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9555:SPR
gene id: 9555:SPR
uniprot id: A0A8I5NN64
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9555:PHOSPHO2
gene id: 9555:PHOSPHO2
uniprot id: A0A096MMF1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9555:TP53INP2
gene id: 9555:TP53INP2
uniprot id: A0A096NUS2
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9555:CDR2L
gene id: 9555:CDR2L
uniprot id: A0A096NST1
names: Similarity
messages: Belongs to the CDR2 family.

9555:GNAI3
gene id: 9555:GNAI3
uniprot id: A0A096NWS6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9555:PHKG1
gene id: 9555:PHKG1
uniprot id: A0A096NG96
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9555:STN1
gene id: 9555:STN1
uniprot id: A0A096P6H8
uniprot id: A0A8I5NKM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9555:MRRF
gene id: 9555:MRRF
uniprot id: A0A096P0N4
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9555:TLL2
gene id: 9555:TLL2
uniprot id: A0A096P5V3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SPOP
gene id: 9555:SPOP
uniprot id: A0A096P456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9555:PDYN
gene id: 9555:PDYN
uniprot id: A0A096NV66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9555:LOC103879121
gene id: 9555:LOC103879121
uniprot id: A0A096NBI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9555:GPN1
gene id: 9555:GPN1
uniprot id: A0A096P001
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9555:LOC101019236
gene id: 9555:LOC101019236
uniprot id: A0A8I5NCQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:CUL4B
gene id: 9555:CUL4B
uniprot id: A0A096NAK2
uniprot id: A0A2I3MIK7
names: Similarity
messages: Belongs to the cullin family.

9555:KDM1B
gene id: 9555:KDM1B
uniprot id: A0A096NL59
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9555:TMEM167B
gene id: 9555:TMEM167B
uniprot id: A0A096N7X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9555:FEV
gene id: 9555:FEV
uniprot id: A0A096N222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:KRT7
gene id: 9555:KRT7
uniprot id: A0A096NEU5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:C14H2orf49
gene id: 9555:C14H2orf49
uniprot id: A0A096N2J3
uniprot id: A0A2I3LCI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9555:CCT8
gene id: 9555:CCT8
uniprot id: A0A2I3MWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: cilium basal body

9555:ZDHHC16
gene id: 9555:ZDHHC16
uniprot id: A0A096P607
uniprot id: A0A2I3M3K0
uniprot id: A0A2I3MUB0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:SCN3B
gene id: 9555:SCN3B
uniprot id: A0A096N6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9555:PGK1
gene id: 9555:PGK1
uniprot id: A0A096NZ57
uniprot id: A0A2I3MH89
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9555:LOC108581327
gene id: 9555:LOC108581327
uniprot id: A0A096N461
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9555:LOC101019907
gene id: 9555:LOC101019907
uniprot id: A0A096MZ95
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9555:FAP
gene id: 9555:FAP
uniprot id: A0A2I3LD45
uniprot id: A0A2I3M6E8
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9555:EPHB4
gene id: 9555:EPHB4
uniprot id: A0A096N812
names: Subcellular Location Annotation
messages: Membrane

9555:MAP7
gene id: 9555:MAP7
uniprot id: A0A096NQW1
uniprot id: A0A2I3LNI0
uniprot id: A0A2I3M353
uniprot id: A0A2I3M973
names: Similarity
messages: Belongs to the MAP7 family.

9555:CNRIP1
gene id: 9555:CNRIP1
uniprot id: A0A8I5NPT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9555:SLC37A1
gene id: 9555:SLC37A1
uniprot id: A0A096NIT6
uniprot id: A0A2I3N849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9555:NLN
gene id: 9555:NLN
uniprot id: A0A096MNJ2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9555:APOBEC2
gene id: 9555:APOBEC2
uniprot id: A0A096NI14
names: Subcellular Location Annotation
messages: Cytoplasm

9555:RAB29
gene id: 9555:RAB29
uniprot id: A0A096MPU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9555:LOC103885307
gene id: 9555:LOC103885307
uniprot id: A0A096MPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9555:CHRNA7
gene id: 9555:CHRNA7
uniprot id: A0A096NT59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:MYOD1
gene id: 9555:MYOD1
uniprot id: A0A096MNT6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9555:PBX1
gene id: 9555:PBX1
uniprot id: A0A096MXS5
uniprot id: A0A2I3MJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9555:JUP
gene id: 9555:JUP
uniprot id: A0A096P5P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9555:SOX10
gene id: 9555:SOX10
uniprot id: A0A096NK02
names: Subcellular Location Annotation
messages: Nucleus

9555:POLD2
gene id: 9555:POLD2
uniprot id: A0A096NYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9555:RTN4
gene id: 9555:RTN4
uniprot id: A0A096N0R3
uniprot id: A0A096NZN7
uniprot id: A0A2I3NF09
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:MTIF3
gene id: 9555:MTIF3
uniprot id: A0A096MQM0
names: Similarity
messages: Belongs to the IF-3 family.

9555:RPL26
gene id: 9555:RPL26
uniprot id: A0A096P2V0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9555:RNF141
gene id: 9555:RNF141
uniprot id: A0A096N839
names: Function
messages: May be involved in spermatogenesis.

9555:SLC7A11
gene id: 9555:SLC7A11
uniprot id: A0A096NG78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9555:FARSB
gene id: 9555:FARSB
uniprot id: A0A096N219
uniprot id: A0A8I5NEM7
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9555:RAG1
gene id: 9555:RAG1
uniprot id: A0A096N450
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9555:LOC103883612
gene id: 9555:LOC103883612
uniprot id: A0A096NHE6
names: Similarity
messages: Belongs to the MHC class II family.

9555:OSBPL7
gene id: 9555:OSBPL7
uniprot id: A0A096P3Z8
uniprot id: A0A2I3MVF7
names: Similarity
messages: Belongs to the OSBP family.

9555:CRCP
gene id: 9555:CRCP
uniprot id: A0A2I3MHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9555:SLC14A1
gene id: 9555:SLC14A1
uniprot id: A0A2I3LF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9555:QTRT2
gene id: 9555:QTRT2
uniprot id: A0A096N3C1
uniprot id: A0A8I5N579
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9555:DR1
gene id: 9555:DR1
uniprot id: A0A2I3LLP5
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9555:GAPDH
gene id: 9555:GAPDH
uniprot id: A0A096NGN6
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9555:DLGAP5
gene id: 9555:DLGAP5
uniprot id: A0A096NV78
names: Similarity
messages: Belongs to the SAPAP family.

9555:CPSF3
gene id: 9555:CPSF3
uniprot id: A0A096NIU8
names: Subcellular Location Annotation
messages: Nucleus

9555:METTL2A
gene id: 9555:METTL2A
uniprot id: A0A096P6B0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9555:NKAPL
gene id: 9555:NKAPL
uniprot id: A0A8I5NWJ8
names: Similarity
messages: Belongs to the NKAP family.

9555:PSAP
gene id: 9555:PSAP
uniprot id: A0A2I3M011
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9555:DHH
gene id: 9555:DHH
uniprot id: A0A096NG69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9555:ABCG2
gene id: 9555:ABCG2
uniprot id: A0A096MN87
uniprot id: A0A8I5NFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9555:CXCR4
gene id: 9555:CXCR4
uniprot id: P56491
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
messages: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.
messages: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.

9555:LOC101011060
gene id: 9555:LOC101011060
uniprot id: A0A096MZA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:SENP3
gene id: 9555:SENP3
uniprot id: A0A096P2Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9555:CNR2
gene id: 9555:CNR2
uniprot id: A0A096NEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:HSPB3
gene id: 9555:HSPB3
uniprot id: A0A096NCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9555:MYF6
gene id: 9555:MYF6
uniprot id: A0A8I5NKC1
names: Subcellular Location Annotation
messages: Nucleus

9555:TMOD1
gene id: 9555:TMOD1
uniprot id: A0A096P138
names: Subcellular Location Annotation
messages: cytoskeleton

9555:PHYHIPL
gene id: 9555:PHYHIPL
uniprot id: A0A096P572
names: Similarity
messages: Belongs to the PHYHIP family.

9555:ERCC4
gene id: 9555:ERCC4
uniprot id: A0A096NLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9555:SLC39A8
gene id: 9555:SLC39A8
uniprot id: A0A096MX81
uniprot id: A0A2I3NIC5
names: Subcellular Location Annotation
messages: Membrane

9555:RNH1
gene id: 9555:RNH1
uniprot id: A0A096N7M0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9555:SLC25A18
gene id: 9555:SLC25A18
uniprot id: A0A096NVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:NPC2
gene id: 9555:NPC2
uniprot id: A0A2I3LDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9555:NEIL3
gene id: 9555:NEIL3
uniprot id: A0A096N2M3
names: Similarity
messages: Belongs to the FPG family.

9555:DPY30
gene id: 9555:DPY30
uniprot id: A0A096NAA2
names: Similarity
messages: Belongs to the dpy-30 family.

9555:ALLC
gene id: 9555:ALLC
uniprot id: A0A096NIM5
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9555:CRYL1
gene id: 9555:CRYL1
uniprot id: A0A096NP27
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9555:TET1
gene id: 9555:TET1
uniprot id: A0A096P519
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9555:FAM102B
gene id: 9555:FAM102B
uniprot id: A0A096NFZ3
names: Similarity
messages: Belongs to the FAM102 family.

9555:ILF3
gene id: 9555:ILF3
uniprot id: A0A0A0MX95
uniprot id: A0A2I3MBY8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ATP2B2
gene id: 9555:ATP2B2
uniprot id: A0A096MPW1
uniprot id: A0A2I3LLL0
uniprot id: A0A2I3MV53
uniprot id: A0A2I3MZ32
uniprot id: A0A2I3NBE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:XPOT
gene id: 9555:XPOT
uniprot id: A0A096MU72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9555:IMPA1
gene id: 9555:IMPA1
uniprot id: A0A096NDL4
uniprot id: A0A8I5NT52
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9555:HOXA9
gene id: 9555:HOXA9
uniprot id: A9L942
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9555:CXCL9
gene id: 9555:CXCL9
uniprot id: A0A8I5NZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:NBL1
gene id: 9555:NBL1
uniprot id: A0A096NEP8
uniprot id: A0A2I3N3V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9555:TRIP13
gene id: 9555:TRIP13
uniprot id: A0A096NC09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9555:ENPP6
gene id: 9555:ENPP6
uniprot id: A0A096NEY1
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9555:TEX10
gene id: 9555:TEX10
uniprot id: A0A2I3M272
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9555:CPE
gene id: 9555:CPE
uniprot id: A0A096MYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Interacts with Secretogranin III/SCG3.
messages: Membrane
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: Vesicle
messages: secretory vesicle membrane

9555:PLCZ1
gene id: 9555:PLCZ1
uniprot id: A0A096MWX9
uniprot id: A0A8I5QZ84
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9555:SMIM12
gene id: 9555:SMIM12
uniprot id: A0A096NS22
names: Similarity
messages: Belongs to the SMIM12 family.

9555:ACSM3
gene id: 9555:ACSM3
uniprot id: A0A096NH85
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:MFF
gene id: 9555:MFF
uniprot id: A0A096NFC4
uniprot id: A0A096NQ48
uniprot id: A0A2I3LDI3
uniprot id: A0A2I3NGD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9555:DNTTIP1
gene id: 9555:DNTTIP1
uniprot id: A0A096NX42
names: Subcellular Location Annotation
messages: Nucleus

9555:PRPF31
gene id: 9555:PRPF31
uniprot id: A9L907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9555:CDC45
gene id: 9555:CDC45
uniprot id: A0A096NBU9
uniprot id: A0A2I3MEB6
uniprot id: A0A2I3MI69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9555:AGT
gene id: 9555:AGT
uniprot id: A0A096N678
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9555:MRAP
gene id: 9555:MRAP
uniprot id: A0A8I5NNS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:CCL19
gene id: 9555:CCL19
uniprot id: A0A2I3MYR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:MFSD11
gene id: 9555:MFSD11
uniprot id: A0A096NT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9555:SPNS1
gene id: 9555:SPNS1
uniprot id: A0A096NHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9555:LOC103880462
gene id: 9555:LOC103880462
uniprot id: A0A8I5MVK6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9555:GNAO1
gene id: 9555:GNAO1
uniprot id: A0A2I3LTE8
uniprot id: A0A2I3MEU8
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9555:MICOS10
gene id: 9555:MICOS10
uniprot id: A0A096NBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9555:DISP3
gene id: 9555:DISP3
uniprot id: A0A096MQG2
names: Subcellular Location Annotation
messages: Membrane

9555:USP14
gene id: 9555:USP14
uniprot id: A0A096MM97
uniprot id: A0A8I5NBP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9555:RPL10A
gene id: 9555:RPL10A
uniprot id: A0A2I3LZJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9555:TMEM267
gene id: 9555:TMEM267
uniprot id: A0A096N1M3
names: Subcellular Location Annotation
messages: Membrane

9555:ACAP2
gene id: 9555:ACAP2
uniprot id: A0A2I3N8X1
uniprot id: A0A2I3NCN3
uniprot id: A0A2I3NGL4
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9555:LAMTOR3
gene id: 9555:LAMTOR3
uniprot id: A0A096MRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9555:DOC2A
gene id: 9555:DOC2A
uniprot id: A0A096NML3
names: Subcellular Location Annotation
messages: Membrane

9555:CELF1
gene id: 9555:CELF1
uniprot id: A0A096NSE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9555:LPCAT1
gene id: 9555:LPCAT1
uniprot id: A0A096MPB3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9555:MED13
gene id: 9555:MED13
uniprot id: A0A096P4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:PLAGL2
gene id: 9555:PLAGL2
uniprot id: A0A096NUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9555:GNAT3
gene id: 9555:GNAT3
uniprot id: A0A096NRM0
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9555:RWDD3
gene id: 9555:RWDD3
uniprot id: A0A096MS01
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:SUFU
gene id: 9555:SUFU
uniprot id: A0A096P6F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9555:SSH3
gene id: 9555:SSH3
uniprot id: A0A096NC18
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9555:POP5
gene id: 9555:POP5
uniprot id: A0A096N4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9555:RPS6KA1
gene id: 9555:RPS6KA1
uniprot id: A0A096MS33
uniprot id: A0A2I3M5W9
uniprot id: A0A2I3NAK5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9555:LOC101016032
gene id: 9555:LOC101016032
uniprot id: A0A096P5W4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9555:SYP
gene id: 9555:SYP
uniprot id: A0A096MN00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9555:PHETA2
gene id: 9555:PHETA2
uniprot id: A0A8I5MV03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9555:LOC101025645
gene id: 9555:LOC101025645
uniprot id: A0A096N1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9555:CDC25A
gene id: 9555:CDC25A
uniprot id: A0A096N005
uniprot id: A0A096NEQ7
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9555:ACSS3
gene id: 9555:ACSS3
uniprot id: A0A096N177
uniprot id: A0A8I5NDI9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:FAM151A
gene id: 9555:FAM151A
uniprot id: A0A096MW15
names: Similarity
messages: Belongs to the FAM151 family.

9555:AIP
gene id: 9555:AIP
uniprot id: A0A096MVH5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9555:SNCA
gene id: 9555:SNCA
uniprot id: A0A2I3N0Z9
uniprot id: A0A2I3NA67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9555:TSSK2
gene id: 9555:TSSK2
uniprot id: A0A8I5R084
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:COG6
gene id: 9555:COG6
uniprot id: A0A096N295
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9555:RPS9
gene id: 9555:RPS9
uniprot id: A9L913
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9555:TAS2R9
gene id: 9555:TAS2R9
uniprot id: A0A8I5NEB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9555:TLR7
gene id: 9555:TLR7
uniprot id: A0A096N836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9555:TMC4
gene id: 9555:TMC4
uniprot id: A9L910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9555:AMPD2
gene id: 9555:AMPD2
uniprot id: A0A096MSZ2
uniprot id: A0A2I3LVJ0
uniprot id: A0A2I3MGR0
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9555:TMEM198
gene id: 9555:TMEM198
uniprot id: B0CM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9555:CDK5
gene id: 9555:CDK5
uniprot id: A0A096MSP7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:ZPR1
gene id: 9555:ZPR1
uniprot id: A9CB27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity).
messages: Belongs to the ZPR1 family.
messages: Cajal body
messages: Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: axon
messages: gem
messages: growth cone
messages: nucleolus
messages: perinuclear region

9555:SLC25A21
gene id: 9555:SLC25A21
uniprot id: A0A096NUN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:MMP26
gene id: 9555:MMP26
uniprot id: A9L8W4
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:TBP
gene id: 9555:TBP
uniprot id: A0A096NGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9555:NPTX1
gene id: 9555:NPTX1
uniprot id: A0A8I5R531
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GNA11
gene id: 9555:GNA11
uniprot id: A0A0A0MWA0
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9555:ST6GALNAC4
gene id: 9555:ST6GALNAC4
uniprot id: A0A096P1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:LSM14B
gene id: 9555:LSM14B
uniprot id: A0A096NND6
names: Similarity
messages: Belongs to the LSM14 family.

9555:IL12B
gene id: 9555:IL12B
uniprot id: Q865Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9555:RBBP5
gene id: 9555:RBBP5
uniprot id: A0A096NH14
names: Subcellular Location Annotation
messages: Nucleus

9555:DIABLO
gene id: 9555:DIABLO
uniprot id: A0A096N562
uniprot id: A0A2I3LGM2
names: Subcellular Location Annotation
messages: Mitochondrion

9555:CRP
gene id: 9555:CRP
uniprot id: A0A096NZ65
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:SERPINA11
gene id: 9555:SERPINA11
uniprot id: A0A096NJJ3
names: Similarity
messages: Belongs to the serpin family.

9555:DACT1
gene id: 9555:DACT1
uniprot id: A0A096NVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9555:WASF2
gene id: 9555:WASF2
uniprot id: A0A096MY18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9555:SLC5A5
gene id: 9555:SLC5A5
uniprot id: A0A0A0MX32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:OTC
gene id: 9555:OTC
uniprot id: A0A096N4P9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9555:GDF5
gene id: 9555:GDF5
uniprot id: B0CM78
names: Similarity
messages: Belongs to the TGF-beta family.

9555:ATP5MC3
gene id: 9555:ATP5MC3
uniprot id: A0A2I3MXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9555:SART1
gene id: 9555:SART1
uniprot id: A0A096MRI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9555:ALDH5A1
gene id: 9555:ALDH5A1
uniprot id: A0A096NLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9555:RNPS1
gene id: 9555:RNPS1
uniprot id: A0A096NL34
uniprot id: A0A2I3MGU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9555:NPY
gene id: 9555:NPY
uniprot id: A0A8I5NK89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9555:PEX12
gene id: 9555:PEX12
uniprot id: A0A096P3X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9555:SMIM18
gene id: 9555:SMIM18
uniprot id: A0A096NEQ9
names: Subcellular Location Annotation
messages: Membrane

9555:SYS1
gene id: 9555:SYS1
uniprot id: A4K2N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity).

9555:ARL1
gene id: 9555:ARL1
uniprot id: A0A096N4C6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9555:ARSK
gene id: 9555:ARSK
uniprot id: A0A096MMD3
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:OCA2
gene id: 9555:OCA2
uniprot id: A0A096NSX9
names: Subcellular Location Annotation
messages: Membrane

9555:TTC33
gene id: 9555:TTC33
uniprot id: A0A096NP50
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9555:HSDL1
gene id: 9555:HSDL1
uniprot id: A0A096N5G0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:SEPTIN10
gene id: 9555:SEPTIN10
uniprot id: A0A096NUD2
uniprot id: A0A2I3LEH4
uniprot id: A0A2I3N1C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9555:CCND3
gene id: 9555:CCND3
uniprot id: A8MN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9555:RHAG
gene id: 9555:RHAG
uniprot id: A0A096NIZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9555:ZDHHC5
gene id: 9555:ZDHHC5
uniprot id: A0A096MZE5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:LRRC7
gene id: 9555:LRRC7
uniprot id: A0A096N713
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9555:CRTC3
gene id: 9555:CRTC3
uniprot id: A0A096NNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9555:ORC4
gene id: 9555:ORC4
uniprot id: A0A096NSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9555:ATG2B
gene id: 9555:ATG2B
uniprot id: A0A096NJM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9555:CCL2
gene id: 9555:CCL2
uniprot id: C9EI28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:SNRPD2
gene id: 9555:SNRPD2
uniprot id: A0A0A0MVC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9555:HLF
gene id: 9555:HLF
uniprot id: A0A096P4P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9555:KDM4C
gene id: 9555:KDM4C
uniprot id: A0A096P1J6
uniprot id: A0A8I5NI57
uniprot id: A0A8I5R8Y8
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9555:GATA6
gene id: 9555:GATA6
uniprot id: A0A096MVE0
names: Subcellular Location Annotation
messages: Nucleus

9555:KDM1A
gene id: 9555:KDM1A
uniprot id: A0A2I3M6T6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9555:LOC101006107
gene id: 9555:LOC101006107
uniprot id: R4TIY2
names: Similarity
messages: Belongs to the apolipoprotein L family.

9555:ZNF277
gene id: 9555:ZNF277
uniprot id: A0A096N1D5
names: Similarity
messages: Belongs to the ZNF277 family.

9555:PAMR1
gene id: 9555:PAMR1
uniprot id: A0A2I3LTA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101016656
gene id: 9555:LOC101016656
uniprot id: A0A096MY25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9555:LAMP3
gene id: 9555:LAMP3
uniprot id: A0A2I3MXM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9555:SLC2A8
gene id: 9555:SLC2A8
uniprot id: A0A096P209
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9555:NDUFA10
gene id: 9555:NDUFA10
uniprot id: A0A096NPA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9555:KLC4
gene id: 9555:KLC4
uniprot id: A0A2I3LIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9555:C6H6orf89
gene id: 9555:C6H6orf89
uniprot id: A0A096NHT3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9555:NR6A1
gene id: 9555:NR6A1
uniprot id: A0A096P0L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:LAGE3
gene id: 9555:LAGE3
uniprot id: A0A096N606
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9555:HABP4
gene id: 9555:HABP4
uniprot id: A0A096P269
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:FAM219B
gene id: 9555:FAM219B
uniprot id: A0A096NMS4
names: Similarity
messages: Belongs to the FAM219 family.

9555:TOPORS
gene id: 9555:TOPORS
uniprot id: A0A096P1D7
uniprot id: A0A2I3NAD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:CACNG7
gene id: 9555:CACNG7
uniprot id: A9L904
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9555:UBE3D
gene id: 9555:UBE3D
uniprot id: A0A2I3MZI3
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9555:SMARCB1
gene id: 9555:SMARCB1
uniprot id: A0A096NWL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9555:SGSH
gene id: 9555:SGSH
uniprot id: A0A096NTB4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:MAPKAPK2
gene id: 9555:MAPKAPK2
uniprot id: A0A096NF58
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:FXYD3
gene id: 9555:FXYD3
uniprot id: A0A0A0MXG6
names: Caution
names: Similarity
messages: Belongs to the FXYD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TRIM54
gene id: 9555:TRIM54
uniprot id: A0A096NF48
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Nucleus
messages: Z line

9555:GNPNAT1
gene id: 9555:GNPNAT1
uniprot id: A0A096NV33
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9555:DGKB
gene id: 9555:DGKB
uniprot id: A0A096N1I6
uniprot id: A0A2I3MWB8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9555:NOL6
gene id: 9555:NOL6
uniprot id: A0A096P1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9555:UGT1A9
gene id: 9555:UGT1A9
uniprot id: Q20CK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:RPN2
gene id: 9555:RPN2
uniprot id: A0A096NLX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9555:MDFI
gene id: 9555:MDFI
uniprot id: A8MN24
names: Similarity
messages: Belongs to the MDFI family.

9555:SH3GL1
gene id: 9555:SH3GL1
uniprot id: A0A2I3N846
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9555:PLCD1
gene id: 9555:PLCD1
uniprot id: A0A096MQS4
uniprot id: A0A2I3MCP9
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9555:ADAMTS1
gene id: 9555:ADAMTS1
uniprot id: A0A096NAB7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:UNK
gene id: 9555:UNK
uniprot id: A0A2I3LCR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9555:RXRG
gene id: 9555:RXRG
uniprot id: A0A096MW06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9555:LOC101019499
gene id: 9555:LOC101019499
uniprot id: A0A8I5R2I8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9555:REEP5
gene id: 9555:REEP5
uniprot id: A0A096N5D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9555:MEMO1
gene id: 9555:MEMO1
uniprot id: A0A096N8U5
names: Similarity
messages: Belongs to the MEMO1 family.

9555:C8H8orf82
gene id: 9555:C8H8orf82
uniprot id: A0A096N203
names: Similarity
messages: Belongs to the UPF0598 family.

9555:SRPX2
gene id: 9555:SRPX2
uniprot id: A0A096N1S5
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9555:PKN2
gene id: 9555:PKN2
uniprot id: A0A096NGK4
uniprot id: A0A2I3N1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9555:SLC25A11
gene id: 9555:SLC25A11
uniprot id: A0A096P2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:GNB2
gene id: 9555:GNB2
uniprot id: A0A2I3MJ20
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9555:UBE2D2
gene id: 9555:UBE2D2
uniprot id: A0A096MTS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:JRK
gene id: 9555:JRK
uniprot id: A0A096MR45
uniprot id: A0A2I3MNU9
uniprot id: A0A2I3N3X7
names: Subcellular Location Annotation
messages: Nucleus

9555:IQCG
gene id: 9555:IQCG
uniprot id: A0A096P1C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9555:RABAC1
gene id: 9555:RABAC1
uniprot id: A0A0A0MUQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9555:KDSR
gene id: 9555:KDSR
uniprot id: A0A2I3MTU8
uniprot id: A0A8I5NHM3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:GGH
gene id: 9555:GGH
uniprot id: A0A8I5NTG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9555:TNFAIP1
gene id: 9555:TNFAIP1
uniprot id: A0A096P384
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9555:PPP1CC
gene id: 9555:PPP1CC
uniprot id: A0A2I3NER2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9555:CRYBB1
gene id: 9555:CRYBB1
uniprot id: A0A096NRG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9555:ATPAF2
gene id: 9555:ATPAF2
uniprot id: A0A096P326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9555:WHAMM
gene id: 9555:WHAMM
uniprot id: A0A096NN10
names: Subcellular Location Annotation
messages: Membrane

9555:SHTN1
gene id: 9555:SHTN1
uniprot id: A0A096NTV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9555:LOC103879435
gene id: 9555:LOC103879435
uniprot id: A0A2I3MU01
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9555:PIGP
gene id: 9555:PIGP
uniprot id: A0A096NJ45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9555:APLNR
gene id: 9555:APLNR
uniprot id: A0A096MNI3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:PTPRK
gene id: 9555:PTPRK
uniprot id: A0A096MQZ0
uniprot id: A0A2I3MAY7
uniprot id: A0A2I3MGP1
uniprot id: A0A2I3MJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9555:STARD3NL
gene id: 9555:STARD3NL
uniprot id: A0A096NQX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:FZD10
gene id: 9555:FZD10
uniprot id: A0A096NAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9555:ME2
gene id: 9555:ME2
uniprot id: A0A2I3MJB3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9555:KRT40
gene id: 9555:KRT40
uniprot id: A0A096P5J4
names: Similarity
messages: Belongs to the intermediate filament family.

9555:FUT11
gene id: 9555:FUT11
uniprot id: A0A2I3MGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9555:ASIC5
gene id: 9555:ASIC5
uniprot id: A0A096NQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9555:KCTD18
gene id: 9555:KCTD18
uniprot id: A0A096MQT6
names: Subcellular Location Annotation
messages: Cell membrane

9555:SFRP4
gene id: 9555:SFRP4
uniprot id: A0A8I5R9I7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:FERMT3
gene id: 9555:FERMT3
uniprot id: A0A096NFX2
names: Similarity
messages: Belongs to the kindlin family.

9555:NRTN
gene id: 9555:NRTN
uniprot id: A0A0A0MWA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9555:DBNDD2
gene id: 9555:DBNDD2
uniprot id: A4K2M1
names: Similarity
messages: Belongs to the dysbindin family.

9555:LOC101001693
gene id: 9555:LOC101001693
uniprot id: A0A096NWH0
uniprot id: A0A2I3LM58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9555:EZR
gene id: 9555:EZR
uniprot id: A0A096NRZ8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9555:YIPF5
gene id: 9555:YIPF5
uniprot id: A0A096MPL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9555:ZFP36
gene id: 9555:ZFP36
uniprot id: A0A8I5N4P0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9555:PDGFA
gene id: 9555:PDGFA
uniprot id: A0A096P4E8
uniprot id: A0A8I5MZ26
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9555:LOC116268605
gene id: 9555:LOC116268605
uniprot id: A0A096MVG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9555:SLC39A14
gene id: 9555:SLC39A14
uniprot id: A0A2I3MVY1
names: Subcellular Location Annotation
messages: Membrane

9555:MRPL37
gene id: 9555:MRPL37
uniprot id: A0A096N932
names: Subcellular Location Annotation
messages: Mitochondrion

9555:AP3M2
gene id: 9555:AP3M2
uniprot id: A0A096N1P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9555:PM20D2
gene id: 9555:PM20D2
uniprot id: A0A096P097
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9555:PLEKHO1
gene id: 9555:PLEKHO1
uniprot id: A0A096N414
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ME3
gene id: 9555:ME3
uniprot id: A0A096MYA2
uniprot id: A0A096MZZ6
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9555:HMGN1
gene id: 9555:HMGN1
uniprot id: B0CM34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9555:LOC101004146
gene id: 9555:LOC101004146
uniprot id: A0A096NE00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:OPRPN
gene id: 9555:OPRPN
uniprot id: A0A096NSK2
names: Subcellular Location Annotation
messages: Secreted

9555:HBD
gene id: 9555:HBD
uniprot id: A9L8X8
names: Similarity
messages: Belongs to the globin family.

9555:LASP1
gene id: 9555:LASP1
uniprot id: A0A096P590
uniprot id: A0A2I3MMJ0
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9555:MTMR2
gene id: 9555:MTMR2
uniprot id: A0A096N9T1
uniprot id: A0A2I3MBM7
uniprot id: A0A8I5NH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9555:ASB11
gene id: 9555:ASB11
uniprot id: A0A2I3LU72
uniprot id: A0A8I5NX98
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:ACAD11
gene id: 9555:ACAD11
uniprot id: A0A096MLX9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9555:SERP1
gene id: 9555:SERP1
uniprot id: A0A096MUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9555:B4GAT1
gene id: 9555:B4GAT1
uniprot id: A0A096MZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:ST3GAL2
gene id: 9555:ST3GAL2
uniprot id: A0A096NYP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:NT5DC2
gene id: 9555:NT5DC2
uniprot id: A0A096MZG9
uniprot id: A0A2I3LQT3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9555:ND4L
gene id: 9555:ND4L
uniprot id: K9MTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9555:PAIP2
gene id: 9555:PAIP2
uniprot id: A0A8I5NKP7
names: Similarity
messages: Belongs to the PAIP2 family.

9555:FBP2
gene id: 9555:FBP2
uniprot id: A0A096P259
uniprot id: A0A8I5NN65
names: Similarity
messages: Belongs to the FBPase class 1 family.

9555:TNP1
gene id: 9555:TNP1
uniprot id: A0A8I5N9B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9555:RNF31
gene id: 9555:RNF31
uniprot id: A0A096NX89
uniprot id: A0A2I3N3Q1
names: Similarity
messages: Belongs to the RBR family.

9555:FAM151B
gene id: 9555:FAM151B
uniprot id: A0A096NED9
names: Similarity
messages: Belongs to the FAM151 family.

9555:RNF168
gene id: 9555:RNF168
uniprot id: A0A096N1J6
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

9555:LOC101013243
gene id: 9555:LOC101013243
uniprot id: A0A096P5M6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:PTMA
gene id: 9555:PTMA
uniprot id: A0A2I3MH52
uniprot id: A0A2I3MZX3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9555:FAM160A1
gene id: 9555:FAM160A1
uniprot id: A0A096NLT1
names: Similarity
messages: Belongs to the FHIP family.

9555:PPP1R14D
gene id: 9555:PPP1R14D
uniprot id: A0A096NTI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9555:CBFA2T2
gene id: 9555:CBFA2T2
uniprot id: A0A2I3MWJ2
names: Similarity
messages: Belongs to the CBFA2T family.

9555:CLPTM1
gene id: 9555:CLPTM1
uniprot id: A0A2I3M151
uniprot id: A0A2I3N0V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9555:KRT222
gene id: 9555:KRT222
uniprot id: A0A2I3MQW1
names: Similarity
messages: Belongs to the intermediate filament family.

9555:CMKLR1
gene id: 9555:CMKLR1
uniprot id: A0A096NCI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9555:LOC101009235
gene id: 9555:LOC101009235
uniprot id: A0A2I3MKQ3
names: Subunit
messages: Monomer.

9555:SPCS3
gene id: 9555:SPCS3
uniprot id: A0A096MLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

9555:ST8SIA3
gene id: 9555:ST8SIA3
uniprot id: A0A096MUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:CPEB2
gene id: 9555:CPEB2
uniprot id: A0A096NZF7
uniprot id: A0A2I3LFL3
uniprot id: A0A2I3MBS9
names: Similarity
messages: Belongs to the RRM CPEB family.

9555:CHST8
gene id: 9555:CHST8
uniprot id: A0A0A0MUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:GJD2
gene id: 9555:GJD2
uniprot id: A0A096NTA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:TFCP2
gene id: 9555:TFCP2
uniprot id: A0A096N7Y9
uniprot id: A0A2I3NHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9555:SLC4A10
gene id: 9555:SLC4A10
uniprot id: A0A096NXL4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:POMT2
gene id: 9555:POMT2
uniprot id: A0A096NS82
uniprot id: A0A8I5NL25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9555:ELOVL5
gene id: 9555:ELOVL5
uniprot id: A0A096NJ96
uniprot id: A0A8I5NMB2
uniprot id: A0A8I5NS71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9555:LOC103885453
gene id: 9555:LOC103885453
uniprot id: A0A096N740
uniprot id: A0A096N9L6
uniprot id: A0A096NB73
uniprot id: A0A2I3MAY2
uniprot id: A0A8I5N8S8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9555:NCEH1
gene id: 9555:NCEH1
uniprot id: A0A2I3MAK8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9555:ELAVL2
gene id: 9555:ELAVL2
uniprot id: A0A2I3M4M7
uniprot id: A0A2I3MKW7
names: Similarity
messages: Belongs to the RRM elav family.

9555:CTSA
gene id: 9555:CTSA
uniprot id: A0A096NX27
names: Similarity
messages: Belongs to the peptidase S10 family.

9555:STAG3
gene id: 9555:STAG3
uniprot id: A0A096NFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9555:NDFIP1
gene id: 9555:NDFIP1
uniprot id: A0A096MS17
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9555:LPCAT2
gene id: 9555:LPCAT2
uniprot id: A0A096NIF3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9555:MBTPS1
gene id: 9555:MBTPS1
uniprot id: A0A096NPH3
names: Similarity
messages: Belongs to the peptidase S8 family.

9555:PPEF1
gene id: 9555:PPEF1
uniprot id: A0A096N7A4
names: Similarity
messages: Belongs to the PPP phosphatase family.

9555:TRAPPC6B
gene id: 9555:TRAPPC6B
uniprot id: A0A2I3N1E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9555:RPL37A
gene id: 9555:RPL37A
uniprot id: A0A2I3MX55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9555:SLC16A6
gene id: 9555:SLC16A6
uniprot id: A0A096NU02
names: Subcellular Location Annotation
messages: Membrane

9555:SNF8
gene id: 9555:SNF8
uniprot id: A0A2I3LLB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9555:SEMA6A
gene id: 9555:SEMA6A
uniprot id: A0A096NEJ4
uniprot id: A0A2I3MG83
uniprot id: A0A2I3MYZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SYT2
gene id: 9555:SYT2
uniprot id: A0A096NPR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9555:MCM8
gene id: 9555:MCM8
uniprot id: A0A2I3LFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9555:PDX1
gene id: 9555:PDX1
uniprot id: A0A096MQW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:IFT43
gene id: 9555:IFT43
uniprot id: A0A096NS62
names: Similarity
messages: Belongs to the IFT43 family.

9555:TMEM189
gene id: 9555:TMEM189
uniprot id: A0A096NNQ3
uniprot id: A0A8I5MWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9555:NDUFA12
gene id: 9555:NDUFA12
uniprot id: A0A096N2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:CD36
gene id: 9555:CD36
uniprot id: A0A096NER7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9555:SLC50A1
gene id: 9555:SLC50A1
uniprot id: A0A2I3LQ77
uniprot id: A0A2I3MVA4
uniprot id: Q95KW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.
messages: Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1 (By similarity).
messages: Membrane

9555:PPIF
gene id: 9555:PPIF
uniprot id: A0A096P4H0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:SNRPD3
gene id: 9555:SNRPD3
uniprot id: A0A096NW53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9555:MT4
gene id: 9555:MT4
uniprot id: A0A096NII3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9555:HARS2
gene id: 9555:HARS2
uniprot id: A0A096NZ15
uniprot id: A0A2I3M6V7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9555:BLM
gene id: 9555:BLM
uniprot id: A0A096NNB3
uniprot id: A0A2I3LVW5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9555:LIPH
gene id: 9555:LIPH
uniprot id: A0A096MSG1
uniprot id: A0A2I3MHU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9555:CCL11
gene id: 9555:CCL11
uniprot id: A0A096P3T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:FAIM2
gene id: 9555:FAIM2
uniprot id: A0A2I3LSN3
uniprot id: A0A2I3MQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9555:TBX15
gene id: 9555:TBX15
uniprot id: A0A2I3N5X6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:CDH18
gene id: 9555:CDH18
uniprot id: A0A096MM45
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:TREM1
gene id: 9555:TREM1
uniprot id: A0A096NI25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:KCNK5
gene id: 9555:KCNK5
uniprot id: A0A096NHZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:LOC101010649
gene id: 9555:LOC101010649
uniprot id: A9RA98
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:SLC35A2
gene id: 9555:SLC35A2
uniprot id: A0A096MVR1
uniprot id: A0A2I3MXV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9555:SEMA3G
gene id: 9555:SEMA3G
uniprot id: A0A096MZ86
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:FNBP1L
gene id: 9555:FNBP1L
uniprot id: A0A2I3LW14
uniprot id: A0A2I3MJ40
uniprot id: A0A2I3MQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9555:SERPIND1
gene id: 9555:SERPIND1
uniprot id: A0A096NS83
names: Similarity
messages: Belongs to the serpin family.

9555:ROCK1
gene id: 9555:ROCK1
uniprot id: A0A096NF71
uniprot id: A0A2I3LC55
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9555:IST1
gene id: 9555:IST1
uniprot id: A0A2I3M7U7
uniprot id: A0A2I3MBT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9555:MC4R
gene id: 9555:MC4R
uniprot id: A0A096ML25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9555:LOC101011847
gene id: 9555:LOC101011847
uniprot id: A0A096N0E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9555:GNG5
gene id: 9555:GNG5
uniprot id: A0A2I3M9L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9555:TRIM6
gene id: 9555:TRIM6
uniprot id: A0A096N4B9
uniprot id: A9L8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9555:MYADML2
gene id: 9555:MYADML2
uniprot id: A0A096N4U6
names: Subcellular Location Annotation
messages: Membrane

9555:MOG
gene id: 9555:MOG
uniprot id: A0A2I3NFI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9555:TAFA2
gene id: 9555:TAFA2
uniprot id: A0A096MT42
names: Similarity
messages: Belongs to the TAFA family.

9555:NAA30
gene id: 9555:NAA30
uniprot id: A0A096NVB0
uniprot id: A0A8I5NG78
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9555:NUBPL
gene id: 9555:NUBPL
uniprot id: A0A096MNH0
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9555:LOC101010515
gene id: 9555:LOC101010515
uniprot id: A0A096N110
uniprot id: A0A2I3MZM8
names: Subunit
messages: Monomer.

9555:PUS3
gene id: 9555:PUS3
uniprot id: A0A096MV16
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9555:RNF121
gene id: 9555:RNF121
uniprot id: A0A096MMB2
names: Subcellular Location Annotation
messages: Membrane

9555:ZFP36L2
gene id: 9555:ZFP36L2
uniprot id: A0A096MWJ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9555:NSFL1C
gene id: 9555:NSFL1C
uniprot id: A0A096NV55
uniprot id: A0A2I3N819
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9555:GJD4
gene id: 9555:GJD4
uniprot id: A0A096P467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:MAP2K1
gene id: 9555:MAP2K1
uniprot id: A0A2I3LF26
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CENPU
gene id: 9555:CENPU
uniprot id: A0A096NXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9555:RNF20
gene id: 9555:RNF20
uniprot id: A0A096P101
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9555:MORF4L1
gene id: 9555:MORF4L1
uniprot id: A0A096NMW6
names: Subcellular Location Annotation
messages: Nucleus

9555:MYO5B
gene id: 9555:MYO5B
uniprot id: A0A096N8M0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:PKD2
gene id: 9555:PKD2
uniprot id: A0A096MXQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9555:GUCA2B
gene id: 9555:GUCA2B
uniprot id: A0A096MT23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9555:SCGN
gene id: 9555:SCGN
uniprot id: A0A096NLE5
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9555:RGS4
gene id: 9555:RGS4
uniprot id: A0A096MRL1
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9555:LIPG
gene id: 9555:LIPG
uniprot id: A0A096MXT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:TMEFF2
gene id: 9555:TMEFF2
uniprot id: A0A096MY77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101008727
gene id: 9555:LOC101008727
uniprot id: A0A096MRQ2
uniprot id: A0A096NYX5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:NAA40
gene id: 9555:NAA40
uniprot id: A0A096N1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9555:SMARCD1
gene id: 9555:SMARCD1
uniprot id: A0A096NFJ9
uniprot id: A0A2I3LY99
names: Similarity
messages: Belongs to the SMARCD family.

9555:WARS1
gene id: 9555:WARS1
uniprot id: A0A096NJR9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9555:GPX5
gene id: 9555:GPX5
uniprot id: A0A096NLL5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9555:TUSC3
gene id: 9555:TUSC3
uniprot id: A0A2I3LUF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:TAF9B
gene id: 9555:TAF9B
uniprot id: A0A096MNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9555:TM9SF3
gene id: 9555:TM9SF3
uniprot id: A0A2I3M736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9555:ZDHHC3
gene id: 9555:ZDHHC3
uniprot id: A0A096N111
uniprot id: A0A2I3N4T1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:SYNGR1
gene id: 9555:SYNGR1
uniprot id: A0A2I3LF98
uniprot id: A0A2I3M421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9555:GALNT17
gene id: 9555:GALNT17
uniprot id: A0A096NFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:SERINC5
gene id: 9555:SERINC5
uniprot id: A0A096MMK8
uniprot id: A0A2I3N5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9555:STOML2
gene id: 9555:STOML2
uniprot id: A0A096P190
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9555:CDKL4
gene id: 9555:CDKL4
uniprot id: A0A096NYN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:BOLA1
gene id: 9555:BOLA1
uniprot id: A0A096NDP8
names: Similarity
messages: Belongs to the BolA/IbaG family.

9555:PSMB6
gene id: 9555:PSMB6
uniprot id: A0A2I3MSP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:CPM
gene id: 9555:CPM
uniprot id: A0A096NEM8
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:APP
gene id: 9555:APP
uniprot id: A0A2I3MNJ9
uniprot id: A0A2I3MTM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9555:SEMA7A
gene id: 9555:SEMA7A
uniprot id: A0A096NMQ7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PPM1G
gene id: 9555:PPM1G
uniprot id: A0A096NQ30
names: Similarity
messages: Belongs to the PP2C family.

9555:RBM22
gene id: 9555:RBM22
uniprot id: A0A096N735
names: Similarity
messages: Belongs to the SLT11 family.

9555:CCKBR
gene id: 9555:CCKBR
uniprot id: A0A8I5NNE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9555:SPTB
gene id: 9555:SPTB
uniprot id: A0A096NVL3
names: Similarity
messages: Belongs to the spectrin family.

9555:APOOL
gene id: 9555:APOOL
uniprot id: A0A2I3NDK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9555:PDZK1IP1
gene id: 9555:PDZK1IP1
uniprot id: A0A2I3M0I0
names: Subcellular Location Annotation
messages: Membrane

9555:NECAP1
gene id: 9555:NECAP1
uniprot id: A0A096N505
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9555:FOXK2
gene id: 9555:FOXK2
uniprot id: A0A096NTP3
names: Subcellular Location Annotation
messages: Nucleus

9555:ACAA2
gene id: 9555:ACAA2
uniprot id: A0A2I3LDK7
uniprot id: A0A2I3MV66
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9555:CAPN9
gene id: 9555:CAPN9
uniprot id: A0A096NFY3
uniprot id: A0A2I3MNZ5
names: Similarity
messages: Belongs to the peptidase C2 family.

9555:ALKBH1
gene id: 9555:ALKBH1
uniprot id: A0A096NSA1
names: Similarity
messages: Belongs to the alkB family.

9555:NDUFA11
gene id: 9555:NDUFA11
uniprot id: A0A0A0MU92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:TPD52L1
gene id: 9555:TPD52L1
uniprot id: A0A2I3M5N8
uniprot id: A0A2I3M8G7
uniprot id: A0A2I3MYC9
uniprot id: A0A2I3N3D4
uniprot id: A0A8I5NL03
names: Similarity
messages: Belongs to the TPD52 family.

9555:FUT7
gene id: 9555:FUT7
uniprot id: A0A8I5NBT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9555:WIF1
gene id: 9555:WIF1
uniprot id: A0A096NXI6
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:C9
gene id: 9555:C9
uniprot id: A0A096N4A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

9555:MBL2
gene id: 9555:MBL2
uniprot id: A0A096P587
names: Function
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.

9555:IDO1
gene id: 9555:IDO1
uniprot id: A0A096N938
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9555:GFRA1
gene id: 9555:GFRA1
uniprot id: A0A096NTT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9555:GGACT
gene id: 9555:GGACT
uniprot id: A0A8I5NWB1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9555:RFX1
gene id: 9555:RFX1
uniprot id: A0A096N0B7
uniprot id: A0A2I3MNT5
uniprot id: A0A8I5NIP2
names: Subcellular Location Annotation
messages: Nucleus

9555:ATP6V1D
gene id: 9555:ATP6V1D
uniprot id: A0A096NVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9555:TIPRL
gene id: 9555:TIPRL
uniprot id: A0A096N0J9
names: Similarity
messages: Belongs to the TIP41 family.

9555:UTP18
gene id: 9555:UTP18
uniprot id: A0A096P4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9555:CLCN6
gene id: 9555:CLCN6
uniprot id: A0A2I3M1Q4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PON3
gene id: 9555:PON3
uniprot id: A0A2I3NG76
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9555:NCOA2
gene id: 9555:NCOA2
uniprot id: A0A096NEQ6
uniprot id: A0A2I3MSV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9555:PXMP4
gene id: 9555:PXMP4
uniprot id: A0A096NUU3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9555:NR2E1
gene id: 9555:NR2E1
uniprot id: B0CM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:CCNE2
gene id: 9555:CCNE2
uniprot id: A0A096MVM7
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9555:TM4SF1
gene id: 9555:TM4SF1
uniprot id: A0A2I3LJ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9555:LOC101011394
gene id: 9555:LOC101011394
uniprot id: A0A8I5R776
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:BRD1
gene id: 9555:BRD1
uniprot id: A0A096NKU6
uniprot id: A0A2I3N4K1
names: Subcellular Location Annotation
messages: Nucleus

9555:BACE2
gene id: 9555:BACE2
uniprot id: A0A096NIY2
uniprot id: A0A096NIY9
uniprot id: A0A2I3NFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Secreted

9555:THBD
gene id: 9555:THBD
uniprot id: A0A8I5NG66
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9555:BCAT1
gene id: 9555:BCAT1
uniprot id: A0A096NP72
uniprot id: A0A2I3LTP3
uniprot id: A0A8I5NUR8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9555:RABGGTA
gene id: 9555:RABGGTA
uniprot id: A0A096NXB1
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9555:LIMS1
gene id: 9555:LIMS1
uniprot id: A0A096N4T4
uniprot id: A0A096NCD2
uniprot id: A0A2I3LUC5
uniprot id: A0A2I3N3D0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9555:YPEL5
gene id: 9555:YPEL5
uniprot id: A0A8I5NVL8
names: Similarity
messages: Belongs to the yippee family.

9555:FARS2
gene id: 9555:FARS2
uniprot id: A0A096NKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9555:SFRP1
gene id: 9555:SFRP1
uniprot id: A0A2I3MJH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:AIFM1
gene id: 9555:AIFM1
uniprot id: A0A096MPH0
uniprot id: A0A2I3NAA8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9555:ATL3
gene id: 9555:ATL3
uniprot id: A0A2I3MEQ1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:TSEN54
gene id: 9555:TSEN54
uniprot id: A0A096NSW0
names: Similarity
messages: Belongs to the SEN54 family.

9555:SERPINA7
gene id: 9555:SERPINA7
uniprot id: A0A096MR94
names: Similarity
messages: Belongs to the serpin family.

9555:RFC2
gene id: 9555:RFC2
uniprot id: A0A2I3LT78
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9555:PPTC7
gene id: 9555:PPTC7
uniprot id: A0A096N2X7
names: Similarity
messages: Belongs to the PP2C family.

9555:UBN1
gene id: 9555:UBN1
uniprot id: A0A096NLH7
uniprot id: A0A2I3N462
names: Similarity
messages: Belongs to the ubinuclein family.

9555:TMEM132D
gene id: 9555:TMEM132D
uniprot id: A0A096MPZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9555:LOC101020329
gene id: 9555:LOC101020329
uniprot id: A0A8I5N9N3
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

9555:FLI1
gene id: 9555:FLI1
uniprot id: A0A096ND40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:EMC9
gene id: 9555:EMC9
uniprot id: A0A096NX73
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9555:NDUFA1
gene id: 9555:NDUFA1
uniprot id: A0A2I3M0X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:NSUN4
gene id: 9555:NSUN4
uniprot id: A0A096N7T6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9555:FAM102A
gene id: 9555:FAM102A
uniprot id: A0A096P1Y9
names: Similarity
messages: Belongs to the FAM102 family.

9555:BOLA2B
gene id: 9555:BOLA2B
uniprot id: A0A2I3N169
names: Similarity
messages: Belongs to the BolA/IbaG family.

9555:PRKAB1
gene id: 9555:PRKAB1
uniprot id: A0A096N4C2
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9555:PPM1F
gene id: 9555:PPM1F
uniprot id: A0A096NSA4
names: Similarity
messages: Belongs to the PP2C family.

9555:CNOT6L
gene id: 9555:CNOT6L
uniprot id: A0A096MQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9555:AKAP8L
gene id: 9555:AKAP8L
uniprot id: A0A0A0MW70
names: Similarity
messages: Belongs to the AKAP95 family.

9555:FBXO25
gene id: 9555:FBXO25
uniprot id: A0A096MRM8
uniprot id: A0A096N939
uniprot id: A0A2I3MGB8
names: Subcellular Location Annotation
messages: Nucleus

9555:ZKSCAN7
gene id: 9555:ZKSCAN7
uniprot id: A0A096N786
names: Subcellular Location Annotation
messages: Nucleus

9555:MAPK8IP3
gene id: 9555:MAPK8IP3
uniprot id: A0A096NKW5
uniprot id: A0A2I3MXH6
names: Similarity
messages: Belongs to the JIP scaffold family.

9555:HYLS1
gene id: 9555:HYLS1
uniprot id: A0A096MS45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9555:LOC101021313
gene id: 9555:LOC101021313
uniprot id: A0A2I3MIV9
names: Similarity
messages: Belongs to the TTC39 family.

9555:KCNT2
gene id: 9555:KCNT2
uniprot id: A0A2I3LN14
uniprot id: A0A2I3MYF3
uniprot id: A0A2I3NFX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:TBR1
gene id: 9555:TBR1
uniprot id: A0A096MY32
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:RIF1
gene id: 9555:RIF1
uniprot id: A0A096NXW8
uniprot id: A0A2I3NFV6
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9555:ACAP3
gene id: 9555:ACAP3
uniprot id: A0A096NQI1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9555:DGKG
gene id: 9555:DGKG
uniprot id: A0A096NC91
uniprot id: A0A2I3ML70
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9555:CILP
gene id: 9555:CILP
uniprot id: A0A096NMD3
names: Subcellular Location Annotation
messages: extracellular matrix

9555:PPAN
gene id: 9555:PPAN
uniprot id: A0A096N908
names: Subcellular Location Annotation
messages: nucleolus

9555:NR1I2
gene id: 9555:NR1I2
uniprot id: A0A096NXL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:FBXO32
gene id: 9555:FBXO32
uniprot id: A0A096MS55
names: Subcellular Location Annotation
messages: Nucleus

9555:CLTA
gene id: 9555:CLTA
uniprot id: A0A096P160
uniprot id: A0A2I3MAW0
uniprot id: A0A2I3MV58
uniprot id: A0A2I3NBR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9555:IRAK1BP1
gene id: 9555:IRAK1BP1
uniprot id: A0A096MNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9555:SLC7A1
gene id: 9555:SLC7A1
uniprot id: A0A096MWQ0
uniprot id: A0A8I5N250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9555:TMEM106B
gene id: 9555:TMEM106B
uniprot id: A0A096NQX8
names: Similarity
messages: Belongs to the TMEM106 family.

9555:UBE2E3
gene id: 9555:UBE2E3
uniprot id: A0A096MYK6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:TRIT1
gene id: 9555:TRIT1
uniprot id: A0A096MMW7
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9555:SNRPB
gene id: 9555:SNRPB
uniprot id: A0A096NV72
uniprot id: A0A2I3LUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9555:FABP5
gene id: 9555:FABP5
uniprot id: A0A096NZ55
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:RAP1GDS1
gene id: 9555:RAP1GDS1
uniprot id: A0A096N2B1
uniprot id: A0A2I3N380
uniprot id: A0A2I3NGI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

9555:IRX5
gene id: 9555:IRX5
uniprot id: A0A096NIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9555:CHURC1
gene id: 9555:CHURC1
uniprot id: A0A096NVL5
names: Similarity
messages: Belongs to the Churchill family.

9555:GATAD1
gene id: 9555:GATAD1
uniprot id: A0A096MZM5
names: Subcellular Location Annotation
messages: Nucleus

9555:GNB3
gene id: 9555:GNB3
uniprot id: A0A096N052
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9555:NLE1
gene id: 9555:NLE1
uniprot id: A0A096P3W2
names: Subcellular Location Annotation
messages: nucleolus

9555:IRF5
gene id: 9555:IRF5
uniprot id: A0A096NUE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:SMYD2
gene id: 9555:SMYD2
uniprot id: A0A096MMN5
uniprot id: A0A8I5N8Q7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9555:RSPO4
gene id: 9555:RSPO4
uniprot id: A0A2I3LXI8
names: Subcellular Location Annotation
messages: Secreted

9555:SLC17A7
gene id: 9555:SLC17A7
uniprot id: A0A0A0MUK5
names: Subcellular Location Annotation
messages: Membrane

9555:HS3ST1
gene id: 9555:HS3ST1
uniprot id: A0A096MMR1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9555:AP4S1
gene id: 9555:AP4S1
uniprot id: A0A096NXG5
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9555:OASL
gene id: 9555:OASL
uniprot id: A0A096NE60
names: Similarity
messages: Belongs to the 2-5A synthase family.

9555:LSM5
gene id: 9555:LSM5
uniprot id: A0A2I3LH84
uniprot id: A0A2I3MJL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9555:DNAJC18
gene id: 9555:DNAJC18
uniprot id: A0A096N9Y2
names: Subcellular Location Annotation
messages: Membrane

9555:ATAT1
gene id: 9555:ATAT1
uniprot id: A0A096NLU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9555:SLITRK2
gene id: 9555:SLITRK2
uniprot id: A0A096MTS4
names: Similarity
messages: Belongs to the SLITRK family.

9555:ACTN2
gene id: 9555:ACTN2
uniprot id: A0A096N9J6
uniprot id: A0A2I3MJZ3
names: Similarity
messages: Belongs to the alpha-actinin family.

9555:KITLG
gene id: 9555:KITLG
uniprot id: A0A096MTX3
uniprot id: A0A096N8B8
uniprot id: A0A8I5NSY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9555:RAB39B
gene id: 9555:RAB39B
uniprot id: A0A096MPB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9555:ITM2B
gene id: 9555:ITM2B
uniprot id: A0A096N2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9555:TAC1
gene id: 9555:TAC1
uniprot id: A0A096NWZ1
uniprot id: A0A2I3MPB5
uniprot id: A0A8I5R1P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9555:LEF1
gene id: 9555:LEF1
uniprot id: A0A096NXR8
uniprot id: A0A2I3LCZ9
uniprot id: A0A2I3MGW1
uniprot id: A0A2I3NEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9555:LOC101015533
gene id: 9555:LOC101015533
uniprot id: A0A096N9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ADAM23
gene id: 9555:ADAM23
uniprot id: A0A096MTA0
uniprot id: A0A2I3LD73
uniprot id: A0A2I3N9Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GPR3
gene id: 9555:GPR3
uniprot id: A0A096MTW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ACADS
gene id: 9555:ACADS
uniprot id: A0A096N9P5
uniprot id: A0A2I3LFH7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9555:WNT2
gene id: 9555:WNT2
uniprot id: A0M8S1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9555:PPP2R5A
gene id: 9555:PPP2R5A
uniprot id: A0A096N8T4
uniprot id: A0A8I5N6U2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9555:IRX6
gene id: 9555:IRX6
uniprot id: A0A096NIE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9555:NOL12
gene id: 9555:NOL12
uniprot id: A0A2I3MM35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9555:RPS13
gene id: 9555:RPS13
uniprot id: A0A2I3MNN3
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9555:CHST3
gene id: 9555:CHST3
uniprot id: A0A096P4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9555:CDH19
gene id: 9555:CDH19
uniprot id: A0A096ML04
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:LPIN2
gene id: 9555:LPIN2
uniprot id: A0A096N963
uniprot id: A0A2I3LUB8
uniprot id: A0A8I5NA39
names: Similarity
messages: Belongs to the lipin family.

9555:LOC101014817
gene id: 9555:LOC101014817
uniprot id: A0A096NG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9555:RIOK2
gene id: 9555:RIOK2
uniprot id: A0A096NES2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9555:LOC101016965
gene id: 9555:LOC101016965
uniprot id: A0A8I5NZI5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9555:KCNJ13
gene id: 9555:KCNJ13
uniprot id: A0A096MY73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9555:B4GALT6
gene id: 9555:B4GALT6
uniprot id: A0A096MU36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9555:KLRK1
gene id: 9555:KLRK1
uniprot id: A3RLP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:LOC101004439
gene id: 9555:LOC101004439
uniprot id: A0A8I5NI93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:BAMBI
gene id: 9555:BAMBI
uniprot id: A0A8I5P3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9555:ERRFI1
gene id: 9555:ERRFI1
uniprot id: A0A096N4S6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9555:CEBPB
gene id: 9555:CEBPB
uniprot id: A0A096NNQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9555:GLO1
gene id: 9555:GLO1
uniprot id: A0A096NHX0
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9555:FGF4
gene id: 9555:FGF4
uniprot id: A0A096MM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9555:TMEM43
gene id: 9555:TMEM43
uniprot id: A0A096MPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9555:VPS37D
gene id: 9555:VPS37D
uniprot id: A0A096N4K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9555:OR51F2
gene id: 9555:OR51F2
uniprot id: A9L901
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:IL17A
gene id: 9555:IL17A
uniprot id: A0A8I5R2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9555:RUNX1T1
gene id: 9555:RUNX1T1
uniprot id: A0A2I3LCQ1
uniprot id: A0A2I3LPI1
names: Similarity
messages: Belongs to the CBFA2T family.

9555:PLA2G1B
gene id: 9555:PLA2G1B
uniprot id: A0A096MS22
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9555:FAM163B
gene id: 9555:FAM163B
uniprot id: A0A096N6V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9555:MRPL22
gene id: 9555:MRPL22
uniprot id: A0A096MTE6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9555:AMPD3
gene id: 9555:AMPD3
uniprot id: A0A096MWG2
uniprot id: A0A2I3LKC5
uniprot id: A0A2I3N6A9
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9555:WDR83OS
gene id: 9555:WDR83OS
uniprot id: A0A8I5NQE5
names: Similarity
messages: Belongs to the Asterix family.

9555:KLHL3
gene id: 9555:KLHL3
uniprot id: A0A096MMK1
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9555:TMEM47
gene id: 9555:TMEM47
uniprot id: A0A8I5N4V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9555:XRCC6
gene id: 9555:XRCC6
uniprot id: A0A096NKB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9555:DHCR7
gene id: 9555:DHCR7
uniprot id: A0A096MM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9555:SELENOO
gene id: 9555:SELENOO
uniprot id: A0A096NKX4
names: Similarity
messages: Belongs to the SELO family.

9555:CNPY2
gene id: 9555:CNPY2
uniprot id: A0A096NH05
names: Similarity
messages: Belongs to the canopy family.

9555:NEU2
gene id: 9555:NEU2
uniprot id: A0A096NQR0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9555:NIBAN2
gene id: 9555:NIBAN2
uniprot id: A0A096P204
names: Similarity
messages: Belongs to the Niban family.

9555:TARBP2
gene id: 9555:TARBP2
uniprot id: A0A096NGJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9555:SELP
gene id: 9555:SELP
uniprot id: A0A096N0S4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ANAPC5
gene id: 9555:ANAPC5
uniprot id: A0A096MPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9555:CLDN20
gene id: 9555:CLDN20
uniprot id: A0A8I5NU16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:GNAI2
gene id: 9555:GNAI2
uniprot id: A0A096MUH7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9555:ALG14
gene id: 9555:ALG14
uniprot id: A0A096NGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

9555:CDS2
gene id: 9555:CDS2
uniprot id: A0A2I3LS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9555:TRIM3
gene id: 9555:TRIM3
uniprot id: A0A2I3M2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9555:GABPA
gene id: 9555:GABPA
uniprot id: A0A096NDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:JRKL
gene id: 9555:JRKL
uniprot id: A0A096N9H7
names: Subcellular Location Annotation
messages: Nucleus

9555:ANP32A
gene id: 9555:ANP32A
uniprot id: A0A096NMH2
names: Similarity
messages: Belongs to the ANP32 family.

9555:SCARB1
gene id: 9555:SCARB1
uniprot id: A0A096NRD6
uniprot id: A0A2I3LT60
names: Similarity
messages: Belongs to the CD36 family.

9555:DCP1A
gene id: 9555:DCP1A
uniprot id: A0A096N7E6
names: Similarity
messages: Belongs to the DCP1 family.

9555:CDKN2AIPNL
gene id: 9555:CDKN2AIPNL
uniprot id: A0A096N5T4
names: Similarity
messages: Belongs to the CARF family.

9555:BBOF1
gene id: 9555:BBOF1
uniprot id: A0A096MWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9555:KRT71
gene id: 9555:KRT71
uniprot id: A0A096N7Y8
names: Similarity
messages: Belongs to the intermediate filament family.

9555:MIPEP
gene id: 9555:MIPEP
uniprot id: A0A096N8C9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9555:DYNLT3
gene id: 9555:DYNLT3
uniprot id: A0A8I5N8I5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9555:PICALM
gene id: 9555:PICALM
uniprot id: A0A2I3MFM3
uniprot id: A0A2I3N8P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9555:ARHGEF2
gene id: 9555:ARHGEF2
uniprot id: A0A2I3M099
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9555:GFRA3
gene id: 9555:GFRA3
uniprot id: A0A096MUN3
names: Similarity
messages: Belongs to the GDNFR family.

9555:PTCD3
gene id: 9555:PTCD3
uniprot id: A0A096NZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9555:MCOLN1
gene id: 9555:MCOLN1
uniprot id: A0A0A0MWC3
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9555:PRPF38A
gene id: 9555:PRPF38A
uniprot id: A0A096MRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9555:RPL22
gene id: 9555:RPL22
uniprot id: A0A096MR24
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9555:PCMTD2
gene id: 9555:PCMTD2
uniprot id: A0A096NN23
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9555:EHD4
gene id: 9555:EHD4
uniprot id: A0A096NTQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9555:LOC101023741
gene id: 9555:LOC101023741
uniprot id: A0A096NIJ1
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.

9555:NDUFB2
gene id: 9555:NDUFB2
uniprot id: A0A096NEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:ETV2
gene id: 9555:ETV2
uniprot id: A0A0A0MWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:GJB1
gene id: 9555:GJB1
uniprot id: A0A096NCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:NCK2
gene id: 9555:NCK2
uniprot id: A0A8I5NIW6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9555:KRT17
gene id: 9555:KRT17
uniprot id: A0A096P5N8
uniprot id: A0A2I3LFF0
names: Similarity
messages: Belongs to the intermediate filament family.

9555:TMEM200A
gene id: 9555:TMEM200A
uniprot id: A0A096NEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9555:SYNGR3
gene id: 9555:SYNGR3
uniprot id: A0A2I3NI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9555:ST3GAL6
gene id: 9555:ST3GAL6
uniprot id: A0A096N896
uniprot id: A0A2I3MFL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:LOC101021550
gene id: 9555:LOC101021550
uniprot id: A0A096N132
uniprot id: A0A2I3MCG2
uniprot id: A0A2I3MTF8
names: Similarity
messages: Belongs to the MHC class I family.

9555:LOC101001218
gene id: 9555:LOC101001218
uniprot id: A0A2I3M8F3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:GRPEL2
gene id: 9555:GRPEL2
uniprot id: A0A096NEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9555:NTS
gene id: 9555:NTS
uniprot id: A0A096N6M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9555:TSPAN12
gene id: 9555:TSPAN12
uniprot id: A0A096MTW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:RHPN1
gene id: 9555:RHPN1
uniprot id: A0A096N421
names: Similarity
messages: Belongs to the RHPN family.

9555:GLRA2
gene id: 9555:GLRA2
uniprot id: A0A096NBC6
uniprot id: A0A2I3N1R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9555:EXT2
gene id: 9555:EXT2
uniprot id: A0A096MXR7
uniprot id: A0A2I3M533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:MAP7D1
gene id: 9555:MAP7D1
uniprot id: A0A096N1G7
names: Similarity
messages: Belongs to the MAP7 family.

9555:CCL21
gene id: 9555:CCL21
uniprot id: A0A8I5R6Z6
names: Subcellular Location Annotation
messages: Secreted

9555:CA3
gene id: 9555:CA3
uniprot id: A0A8I5NDT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9555:PYGM
gene id: 9555:PYGM
uniprot id: B0CM64
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9555:MTTP
gene id: 9555:MTTP
uniprot id: A0A2I3MW71
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NIPAL3
gene id: 9555:NIPAL3
uniprot id: A0A096MPY1
uniprot id: A0A2I3N545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9555:MRPL44
gene id: 9555:MRPL44
uniprot id: A0A2I3LF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9555:MKRN2
gene id: 9555:MKRN2
uniprot id: A0A096MQN2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:TMED1
gene id: 9555:TMED1
uniprot id: A0A0A0MW85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9555:PARVG
gene id: 9555:PARVG
uniprot id: A0A096NKK9
uniprot id: A0A8I5R9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9555:CHMP4C
gene id: 9555:CHMP4C
uniprot id: A0A096N241
names: Similarity
messages: Belongs to the SNF7 family.

9555:STT3A
gene id: 9555:STT3A
uniprot id: A0A096NAD0
uniprot id: A0A2I3LRP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9555:FCHO2
gene id: 9555:FCHO2
uniprot id: A0A096MWN0
uniprot id: A0A2I3LI71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9555:PRICKLE3
gene id: 9555:PRICKLE3
uniprot id: A0A096NQH7
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9555:PLPP4
gene id: 9555:PLPP4
uniprot id: A0A096NTZ9
uniprot id: A0A2I3MND4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9555:SLC29A1
gene id: 9555:SLC29A1
uniprot id: A0A096NIK3
uniprot id: A0A2I3LSG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9555:CSNK2A1
gene id: 9555:CSNK2A1
uniprot id: A0A096NV36
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CSF1R
gene id: 9555:CSF1R
uniprot id: A0A096ND57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9555:TRAPPC4
gene id: 9555:TRAPPC4
uniprot id: A0A096ML79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9555:LOC101003703
gene id: 9555:LOC101003703
uniprot id: A0A096N4U1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9555:TPM4
gene id: 9555:TPM4
uniprot id: A0A0A0MUC2
uniprot id: A0A2I3LFI5
uniprot id: A0A2I3M5P6
uniprot id: A0A2I3MP06
uniprot id: A0A8I5N905
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9555:BRCA1
gene id: 9555:BRCA1
uniprot id: A0A075VSV6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9555:TAAR5
gene id: 9555:TAAR5
uniprot id: A0A096N6M7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:CSF3R
gene id: 9555:CSF3R
uniprot id: A0A096NRD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9555:WWOX
gene id: 9555:WWOX
uniprot id: A0A096N3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9555:PLAUR
gene id: 9555:PLAUR
uniprot id: A0A0A0MWN2
uniprot id: A0A2I3LIE9
names: Function
names: Subcellular Location Annotation
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
messages: Cell membrane
messages: Membrane
messages: invadopodium membrane

9555:SVBP
gene id: 9555:SVBP
uniprot id: A0A096NCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9555:BLMH
gene id: 9555:BLMH
uniprot id: A0A096P3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9555:TIPARP
gene id: 9555:TIPARP
uniprot id: A0A096NAY2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:MAD1L1
gene id: 9555:MAD1L1
uniprot id: A0A096NSI9
names: Similarity
messages: Belongs to the MAD1 family.

9555:NACC1
gene id: 9555:NACC1
uniprot id: A0A0A0MUH9
names: Subcellular Location Annotation
messages: Nucleus

9555:CASTOR1
gene id: 9555:CASTOR1
uniprot id: A0A2I3N4F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9555:LOC101007034
gene id: 9555:LOC101007034
uniprot id: A0A096NCG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:EIF3J
gene id: 9555:EIF3J
uniprot id: A0A096NRC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9555:TRIM34
gene id: 9555:TRIM34
uniprot id: A0A096N9B8
uniprot id: A9L8Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9555:TVP23B
gene id: 9555:TVP23B
uniprot id: A0A8I5NLX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9555:CD247
gene id: 9555:CD247
uniprot id: Q09TK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9555:POP7
gene id: 9555:POP7
uniprot id: A0A096N668
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9555:RACK1
gene id: 9555:RACK1
uniprot id: A0A096MQ02
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9555:BCL7C
gene id: 9555:BCL7C
uniprot id: A0A096NHV7
uniprot id: A0A096NHV8
names: Similarity
messages: Belongs to the BCL7 family.

9555:AK6
gene id: 9555:AK6
uniprot id: A0A8I5N3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9555:IDE
gene id: 9555:IDE
uniprot id: A0A096P5K6
uniprot id: A0A096P5L0
uniprot id: A0A8I5NYE6
names: Similarity
messages: Belongs to the peptidase M16 family.

9555:GJA5
gene id: 9555:GJA5
uniprot id: A0A096NXH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:UGT1A1
gene id: 9555:UGT1A1
uniprot id: Q20CL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:HCN3
gene id: 9555:HCN3
uniprot id: A0A096MW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9555:RARB
gene id: 9555:RARB
uniprot id: A0A096NAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:IQSEC1
gene id: 9555:IQSEC1
uniprot id: A0A096N3B7
uniprot id: A0A2I3MGL4
uniprot id: A0A2I3MKE5
uniprot id: A0A2I3N5L9
names: Similarity
messages: Belongs to the BRAG family.

9555:LOC100998797
gene id: 9555:LOC100998797
uniprot id: A0A2I3LPQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9555:XKR7
gene id: 9555:XKR7
uniprot id: A0A096NUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9555:CAST
gene id: 9555:CAST
uniprot id: A0A2I3LCQ6
uniprot id: A0A2I3N315
uniprot id: A0A2I3NBZ6
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9555:MTERF3
gene id: 9555:MTERF3
uniprot id: A0A096N7N9
names: Similarity
messages: Belongs to the mTERF family.

9555:PLIN1
gene id: 9555:PLIN1
uniprot id: A0A096NN84
names: Similarity
messages: Belongs to the perilipin family.

9555:ALG6
gene id: 9555:ALG6
uniprot id: A0A096NBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:CDC26
gene id: 9555:CDC26
uniprot id: A0A8I5NKK5
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9555:ANXA5
gene id: 9555:ANXA5
uniprot id: A0A096NA81
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9555:CPLANE2
gene id: 9555:CPLANE2
uniprot id: A0A096NXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9555:MPV17
gene id: 9555:MPV17
uniprot id: A0A096NH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9555:GAA
gene id: 9555:GAA
uniprot id: A0A096NTB1
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SCARB2
gene id: 9555:SCARB2
uniprot id: A0A096MVW2
names: Similarity
messages: Belongs to the CD36 family.

9555:SDHAF2
gene id: 9555:SDHAF2
uniprot id: A0A096NGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9555:CDK20
gene id: 9555:CDK20
uniprot id: A0A2I3MEM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:METTL14
gene id: 9555:METTL14
uniprot id: A0A096MUU6
names: Similarity
messages: Belongs to the MT-A70-like family.

9555:APC
gene id: 9555:APC
uniprot id: A0A096MN94
uniprot id: A0A2I3LIJ9
uniprot id: A0A2I3MTS7
uniprot id: A0A2I3MYN3
uniprot id: A0A8I5NR64
uniprot id: A0A8I5R541
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9555:TMEM11
gene id: 9555:TMEM11
uniprot id: A0A8I5NBD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9555:RPS24
gene id: 9555:RPS24
uniprot id: A0A2I3LT27
uniprot id: A0A2I3MDJ9
uniprot id: A0A2I3N7A7
uniprot id: A0A2I3N8X3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9555:NFU1
gene id: 9555:NFU1
uniprot id: A0A096NUG8
names: Similarity
messages: Belongs to the NifU family.

9555:CAMK1G
gene id: 9555:CAMK1G
uniprot id: A0A096NAP5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:SLC16A8
gene id: 9555:SLC16A8
uniprot id: A0A096NK08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9555:ECHDC1
gene id: 9555:ECHDC1
uniprot id: A0A096MV85
uniprot id: A0A2I3MS70
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9555:TNFRSF9
gene id: 9555:TNFRSF9
uniprot id: A0A096N4S7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NTNG1
gene id: 9555:NTNG1
uniprot id: A0A096NQ63
uniprot id: A0A096P019
uniprot id: A0A2I3MS97
uniprot id: A0A2I3N5X7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ST6GALNAC3
gene id: 9555:ST6GALNAC3
uniprot id: A0A096MLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:PROM1
gene id: 9555:PROM1
uniprot id: A0A096NZG9
uniprot id: A0A2I3MCG0
uniprot id: A0A2I3MCX5
uniprot id: A0A2I3MFP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9555:LOC101026069
gene id: 9555:LOC101026069
uniprot id: A0A096N438
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9555:MDM4
gene id: 9555:MDM4
uniprot id: A0A096MYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9555:DYNC1I2
gene id: 9555:DYNC1I2
uniprot id: A0A096NZI0
uniprot id: A0A2I3LYG4
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9555:TXNL4B
gene id: 9555:TXNL4B
uniprot id: A0A096NGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9555:MPI
gene id: 9555:MPI
uniprot id: A0A096NMS2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9555:SLC6A4
gene id: 9555:SLC6A4
uniprot id: A0A096P3L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9555:MYO1D
gene id: 9555:MYO1D
uniprot id: A0A2I3N540
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:ERO1B
gene id: 9555:ERO1B
uniprot id: A0A2I3M8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9555:MANBAL
gene id: 9555:MANBAL
uniprot id: A0A096NXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9555:ALDOB
gene id: 9555:ALDOB
uniprot id: A0A096P102
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9555:SUSD3
gene id: 9555:SUSD3
uniprot id: A0A2I3LEK8
uniprot id: A0A8I5NTG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SLC25A28
gene id: 9555:SLC25A28
uniprot id: A0A2I3ND84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:UNC5D
gene id: 9555:UNC5D
uniprot id: A0A2I3MIP8
uniprot id: A0A2I3ML14
uniprot id: A0A2I3MMZ7
uniprot id: A0A2I3MPQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9555:LOC101025966
gene id: 9555:LOC101025966
uniprot id: A0A8I5NMF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:HCFC1
gene id: 9555:HCFC1
uniprot id: A0A096NAF2
uniprot id: A9CB52
names: Subcellular Location Annotation
messages: Nucleus

9555:CP
gene id: 9555:CP
uniprot id: A0A096NQN8
uniprot id: A0A2I3LSC7
names: Similarity
messages: Belongs to the multicopper oxidase family.

9555:PADI6
gene id: 9555:PADI6
uniprot id: A0A2I3LKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9555:SPG7
gene id: 9555:SPG7
uniprot id: A0A096NZZ6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9555:WASHC3
gene id: 9555:WASHC3
uniprot id: A0A096MU01
uniprot id: A0A8I5N220
names: Similarity
messages: Belongs to the CCDC53 family.

9555:CLUAP1
gene id: 9555:CLUAP1
uniprot id: A0A2I3LXR9
uniprot id: A0A2I3MC02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9555:ZNRD1
gene id: 9555:ZNRD1
uniprot id: A0A096NLQ3
uniprot id: A0A8I5NGH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9555:HPGD
gene id: 9555:HPGD
uniprot id: A0A096N864
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:LOC103876009
gene id: 9555:LOC103876009
uniprot id: A0A8I5NFY8
names: Similarity
messages: Belongs to the LCE family.

9555:FCF1
gene id: 9555:FCF1
uniprot id: A0A096NQ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9555:TMPRSS5
gene id: 9555:TMPRSS5
uniprot id: A0A096MY98
uniprot id: A0A2I3MV63
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:WDR12
gene id: 9555:WDR12
uniprot id: A0A096MS96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9555:PADI2
gene id: 9555:PADI2
uniprot id: A0A096MV57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9555:SORCS1
gene id: 9555:SORCS1
uniprot id: A0A2I3LUP3
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9555:PDLIM1
gene id: 9555:PDLIM1
uniprot id: A0A096P5Q9
names: Subcellular Location Annotation
messages: Z line

9555:CCNYL1
gene id: 9555:CCNYL1
uniprot id: A0A096MLE9
uniprot id: A0A2I3NGB4
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9555:SLC2A2
gene id: 9555:SLC2A2
uniprot id: A0A096MZ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9555:HNF1B
gene id: 9555:HNF1B
uniprot id: A0A2I3N8U8
uniprot id: A0A2I3NCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9555:SNX32
gene id: 9555:SNX32
uniprot id: A0A096MMD1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9555:UGT1A4
gene id: 9555:UGT1A4
uniprot id: Q20CL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:ATP23
gene id: 9555:ATP23
uniprot id: A0A2I3LE10
names: Similarity
messages: Belongs to the peptidase M76 family.

9555:MRPL33
gene id: 9555:MRPL33
uniprot id: A0A8I5NHT6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9555:PTGER3
gene id: 9555:PTGER3
uniprot id: A0A096N4S2
uniprot id: A0A2I3MHE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:PDCD5
gene id: 9555:PDCD5
uniprot id: A0A8I5MVR8
names: Similarity
messages: Belongs to the PDCD5 family.

9555:YIPF4
gene id: 9555:YIPF4
uniprot id: A0A096NAA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9555:LSM1
gene id: 9555:LSM1
uniprot id: A0A096NFU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9555:BET1
gene id: 9555:BET1
uniprot id: A0A096MWI5
uniprot id: A0A8I5NKM0
names: Subcellular Location Annotation
messages: Membrane

9555:STOM
gene id: 9555:STOM
uniprot id: A0A096P0P4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9555:SH3BGRL
gene id: 9555:SH3BGRL
uniprot id: A0A096MME1
names: Similarity
messages: Belongs to the SH3BGR family.

9555:PCYOX1
gene id: 9555:PCYOX1
uniprot id: A0A096NPE9
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9555:SUV39H2
gene id: 9555:SUV39H2
uniprot id: A0A096P3I3
uniprot id: A0A2I3NBF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9555:ARMCX3
gene id: 9555:ARMCX3
uniprot id: A0A096NP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9555:SLC43A3
gene id: 9555:SLC43A3
uniprot id: A0A096NA59
names: Subcellular Location Annotation
messages: Membrane

9555:F11R
gene id: 9555:F11R
uniprot id: A0A096N4D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9555:OTOP1
gene id: 9555:OTOP1
uniprot id: A0A096NZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9555:XAGE3
gene id: 9555:XAGE3
uniprot id: A0A096N835
uniprot id: A0A2I3M654
names: Similarity
messages: Belongs to the GAGE family.

9555:PPFIA1
gene id: 9555:PPFIA1
uniprot id: A0A096N555
uniprot id: A0A096NDD0
uniprot id: A0A2I3LE24
uniprot id: A0A2I3MXI1
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9555:FOXF1
gene id: 9555:FOXF1
uniprot id: A0A096MYS8
names: Subcellular Location Annotation
messages: Nucleus

9555:TRPC7
gene id: 9555:TRPC7
uniprot id: A0A096MPL4
names: Subcellular Location Annotation
messages: Membrane

9555:GPR108
gene id: 9555:GPR108
uniprot id: A0A0A0MWY4
names: Subcellular Location Annotation
messages: Membrane

9555:CLDN2
gene id: 9555:CLDN2
uniprot id: A0A096NAC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:SIRT4
gene id: 9555:SIRT4
uniprot id: A0A096MZT3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9555:ERP29
gene id: 9555:ERP29
uniprot id: A0A096NE61
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9555:NR4A2
gene id: 9555:NR4A2
uniprot id: A0A2I3MAU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9555:GDF2
gene id: 9555:GDF2
uniprot id: A0A2I3LGS2
names: Similarity
messages: Belongs to the TGF-beta family.

9555:GDF11
gene id: 9555:GDF11
uniprot id: A0A096MW05
names: Similarity
messages: Belongs to the TGF-beta family.

9555:MED26
gene id: 9555:MED26
uniprot id: A0A2I3MXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9555:MINDY2
gene id: 9555:MINDY2
uniprot id: A0A096NM79
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9555:TMEM214
gene id: 9555:TMEM214
uniprot id: A0A096NYP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:IMMP2L
gene id: 9555:IMMP2L
uniprot id: A0A2I3NHU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9555:CHRNA9
gene id: 9555:CHRNA9
uniprot id: A0A8I5NRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:MED31
gene id: 9555:MED31
uniprot id: A0A096P2L2
uniprot id: A0A8I5R047
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9555:DYNLRB1
gene id: 9555:DYNLRB1
uniprot id: A0A096NUS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9555:CDK2
gene id: 9555:CDK2
uniprot id: A0A096MYH8
uniprot id: A0A2I3MV08
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:MYO1B
gene id: 9555:MYO1B
uniprot id: A0A096NWU2
uniprot id: A0A2I3NB04
uniprot id: A0A2I3NF97
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:MRS2
gene id: 9555:MRS2
uniprot id: A0A096NLA8
uniprot id: A0A2I3LKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9555:USP5
gene id: 9555:USP5
uniprot id: A0A096NXI9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9555:LOC101024127
gene id: 9555:LOC101024127
uniprot id: A0A096NX88
names: Similarity
messages: Belongs to the CCN family.

9555:DCTN1
gene id: 9555:DCTN1
uniprot id: A0A096NGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9555:VWC2
gene id: 9555:VWC2
uniprot id: A0A096NDN1
names: Subcellular Location Annotation
messages: Synapse

9555:IDH3A
gene id: 9555:IDH3A
uniprot id: A0A2I3N7H1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9555:PSMC3IP
gene id: 9555:PSMC3IP
uniprot id: A0A096P5T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9555:PFDN6
gene id: 9555:PFDN6
uniprot id: A0A096NHH3
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9555:RORA
gene id: 9555:RORA
uniprot id: A0A096NM90
uniprot id: A0A2I3ND74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:S100A5
gene id: 9555:S100A5
uniprot id: A0A096MUG5
names: Similarity
messages: Belongs to the S-100 family.

9555:LOC101006249
gene id: 9555:LOC101006249
uniprot id: A0A096NAW3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:TBL1X
gene id: 9555:TBL1X
uniprot id: A0A096MZ67
names: Similarity
messages: Belongs to the WD repeat EBI family.

9555:GGA2
gene id: 9555:GGA2
uniprot id: A0A096NHE7
uniprot id: A0A2I3M6H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9555:TXNRD1
gene id: 9555:TXNRD1
uniprot id: A0A2I3LX18
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9555:TADA3
gene id: 9555:TADA3
uniprot id: A0A096MUD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9555:REV1
gene id: 9555:REV1
uniprot id: A0A096N1D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9555:PHACTR2
gene id: 9555:PHACTR2
uniprot id: A0A096NGW0
uniprot id: A0A2I3MQN8
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9555:PPP1R9A
gene id: 9555:PPP1R9A
uniprot id: A0A096MNQ8
uniprot id: A0A2I3M2B9
uniprot id: A0A2I3N216
uniprot id: A0A2I3NCN6
names: Subcellular Location Annotation
messages: cytoskeleton

9555:C11H10orf90
gene id: 9555:C11H10orf90
uniprot id: A0A2I3LT04
names: Subcellular Location Annotation
messages: centrosome

9555:MGMT
gene id: 9555:MGMT
uniprot id: A0A096NSU1
uniprot id: A0A8I5N8Z0
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9555:ANXA1
gene id: 9555:ANXA1
uniprot id: A0A8I5MZ82
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9555:FMNL1
gene id: 9555:FMNL1
uniprot id: A0A096P662
uniprot id: A0A2I3ND63
names: Similarity
messages: Belongs to the formin homology family.

9555:EBPL
gene id: 9555:EBPL
uniprot id: A0A096MZV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:IZUMO2
gene id: 9555:IZUMO2
uniprot id: A0A0A0MUK3
names: Similarity
messages: Belongs to the Izumo family.

9555:CREB1
gene id: 9555:CREB1
uniprot id: A0A096MS95
uniprot id: A0A2I3M6F6
names: Subcellular Location Annotation
messages: Nucleus

9555:SLC45A1
gene id: 9555:SLC45A1
uniprot id: A0A096N3E8
names: Subcellular Location Annotation
messages: Membrane

9555:CNIH4
gene id: 9555:CNIH4
uniprot id: A0A2I3LVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9555:TLCD1
gene id: 9555:TLCD1
uniprot id: A0A096P3C1
uniprot id: A0A2I3N6Q0
names: Subcellular Location Annotation
messages: Membrane

9555:TATDN1
gene id: 9555:TATDN1
uniprot id: A0A096MTI9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9555:MAPK13
gene id: 9555:MAPK13
uniprot id: A0A2I3NCE1
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9555:FAM221B
gene id: 9555:FAM221B
uniprot id: A0A096P166
names: Similarity
messages: Belongs to the FAM221 family.

9555:FZR1
gene id: 9555:FZR1
uniprot id: A0A0A0MX74
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9555:PROS1
gene id: 9555:PROS1
uniprot id: A0A096MT68
uniprot id: A0A096N4I1
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CDH1
gene id: 9555:CDH1
uniprot id: A0A096MNS2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9555:RSRP1
gene id: 9555:RSRP1
uniprot id: A0A096N526
names: Similarity
messages: Belongs to the RSRP family.

9555:LOC101021604
gene id: 9555:LOC101021604
uniprot id: A0A096N3A5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9555:PRPF18
gene id: 9555:PRPF18
uniprot id: A0A096P3G9
uniprot id: A0A096P3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9555:HOXC9
gene id: 9555:HOXC9
uniprot id: A0A8I5NHN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9555:LOC101025074
gene id: 9555:LOC101025074
uniprot id: A0A2I3NEH1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9555:TXN
gene id: 9555:TXN
uniprot id: A0A2I3M4A4
names: Similarity
messages: Belongs to the thioredoxin family.

9555:SLC25A36
gene id: 9555:SLC25A36
uniprot id: A0A2I3N4U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:GGA3
gene id: 9555:GGA3
uniprot id: A0A096NSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9555:GTPBP1
gene id: 9555:GTPBP1
uniprot id: A0A8I5R556
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

9555:HOXA4
gene id: 9555:HOXA4
uniprot id: A9L939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:TJP2
gene id: 9555:TJP2
uniprot id: A0A096P1P9
uniprot id: A0A2I3LNW4
uniprot id: A0A2I3M5P7
uniprot id: A0A2I3MXH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9555:LOC101004259
gene id: 9555:LOC101004259
uniprot id: A0A2I3M0J6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9555:SCAMP4
gene id: 9555:SCAMP4
uniprot id: A0A2I3MRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9555:SLC43A2
gene id: 9555:SLC43A2
uniprot id: A0A096P2A1
uniprot id: A0A2I3MF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

9555:MED8
gene id: 9555:MED8
uniprot id: A0A2I3LC98
uniprot id: A0A2I3M366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:KATNAL1
gene id: 9555:KATNAL1
uniprot id: A9RA82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity).
messages: cytoskeleton
messages: spindle
messages: spindle pole

9555:BCAN
gene id: 9555:BCAN
uniprot id: A0A096NDK6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:CTSV
gene id: 9555:CTSV
uniprot id: A0A096P274
uniprot id: A0A8I5NT33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9555:DIPK2B
gene id: 9555:DIPK2B
uniprot id: A0A096MLD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9555:COX8A
gene id: 9555:COX8A
uniprot id: Q863G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9555:HINT1
gene id: 9555:HINT1
uniprot id: A0A8I5R0N7
names: Similarity
messages: Belongs to the HINT family.

9555:GALNT7
gene id: 9555:GALNT7
uniprot id: A0A096N2H6
uniprot id: A0A2I3MUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:SUSD4
gene id: 9555:SUSD4
uniprot id: A0A096MN67
uniprot id: A0A2I3N7M9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:POLR3H
gene id: 9555:POLR3H
uniprot id: A0A096NKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9555:PEX5
gene id: 9555:PEX5
uniprot id: A0A2I3LZW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9555:XPO6
gene id: 9555:XPO6
uniprot id: A0A096NHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9555:EIF3A
gene id: 9555:EIF3A
uniprot id: A0A096NTX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9555:DNAJC2
gene id: 9555:DNAJC2
uniprot id: A0A096NGR0
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

9555:PPOX
gene id: 9555:PPOX
uniprot id: A0A096ML65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9555:SLC5A2
gene id: 9555:SLC5A2
uniprot id: A0A096NHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:TASOR2
gene id: 9555:TASOR2
uniprot id: A0A096P3B8
uniprot id: A0A2I3NAW8
uniprot id: A0A8I5NAH1
names: Similarity
messages: Belongs to the TASOR family.

9555:FTH1
gene id: 9555:FTH1
uniprot id: A0A096MPD7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9555:LOC100997079
gene id: 9555:LOC100997079
uniprot id: A0A096N933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:MPP7
gene id: 9555:MPP7
uniprot id: A0A096P3W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9555:HAMP
gene id: 9555:HAMP
uniprot id: A0A0A0MUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9555:LOC101001645
gene id: 9555:LOC101001645
uniprot id: A0A096NM40
uniprot id: A0A8I5NFE1
names: Subcellular Location Annotation
messages: cytoskeleton

9555:NDFIP2
gene id: 9555:NDFIP2
uniprot id: A0A2I3NDB5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9555:MRPL19
gene id: 9555:MRPL19
uniprot id: A0A096MVX2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9555:C8G
gene id: 9555:C8G
uniprot id: A0A096NRQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9555:STMN4
gene id: 9555:STMN4
uniprot id: A0A096N8M9
uniprot id: A0A2I3NGF5
names: Similarity
messages: Belongs to the stathmin family.

9555:LYN
gene id: 9555:LYN
uniprot id: A0A096MX07
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:CUEDC2
gene id: 9555:CUEDC2
uniprot id: A0A096P6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9555:SSU72
gene id: 9555:SSU72
uniprot id: A0A2I3MGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9555:CTNNAL1
gene id: 9555:CTNNAL1
uniprot id: A0A096P0X9
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9555:LOC101021713
gene id: 9555:LOC101021713
uniprot id: A0A096P6D9
names: Similarity
messages: Belongs to the TACO1 family.

9555:RPL27
gene id: 9555:RPL27
uniprot id: A0A096P5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9555:MDH1B
gene id: 9555:MDH1B
uniprot id: A0A096N6Y7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9555:ICAM1
gene id: 9555:ICAM1
uniprot id: A0A0A0MV70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9555:NKD1
gene id: 9555:NKD1
uniprot id: A0A096NI81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:PPP1R15B
gene id: 9555:PPP1R15B
uniprot id: A0A096NBH3
names: Similarity
messages: Belongs to the PPP1R15 family.

9555:CXCR6
gene id: 9555:CXCR6
uniprot id: A0A096MQA3
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9555:LOC101012101
gene id: 9555:LOC101012101
uniprot id: A0A096NQ71
names: Similarity
messages: Belongs to the 14-3-3 family.

9555:VSIG1
gene id: 9555:VSIG1
uniprot id: A0A096NBD1
uniprot id: A0A2I3MGW0
names: Subcellular Location Annotation
messages: Membrane

9555:TTR
gene id: 9555:TTR
uniprot id: A0A2I3MUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9555:TUBA8
gene id: 9555:TUBA8
uniprot id: A0A096NUK1
uniprot id: A0A2I3LCG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9555:CBX4
gene id: 9555:CBX4
uniprot id: A0A8I5NAF3
names: Subcellular Location Annotation
messages: Nucleus

9555:ANAPC15
gene id: 9555:ANAPC15
uniprot id: A0A2I3LKQ0
names: Similarity
messages: Belongs to the APC15 family.

9555:USP2
gene id: 9555:USP2
uniprot id: A0A096NFG7
uniprot id: A0A2I3LPE4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9555:PTX3
gene id: 9555:PTX3
uniprot id: A0A096N0W7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:MAPK9
gene id: 9555:MAPK9
uniprot id: A0A096NDC4
uniprot id: A0A2I3LEY1
uniprot id: A0A2I3M9T9
uniprot id: A0A2I3MW42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9555:PGAP2
gene id: 9555:PGAP2
uniprot id: A0A096MMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9555:FAM47E
gene id: 9555:FAM47E
uniprot id: A0A2I3MN93
names: Similarity
messages: Belongs to the FAM47 family.

9555:FPR3
gene id: 9555:FPR3
uniprot id: A0A8I5NK48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9555:TNFRSF11B
gene id: 9555:TNFRSF11B
uniprot id: A0A096N1R7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:EIF4EBP2
gene id: 9555:EIF4EBP2
uniprot id: A0A8I5NUK3
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9555:PKD2L2
gene id: 9555:PKD2L2
uniprot id: A0A2I3LG39
uniprot id: A0A2I3MLQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9555:CACNA1D
gene id: 9555:CACNA1D
uniprot id: A0A2I3MXE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9555:TUBB2A
gene id: 9555:TUBB2A
uniprot id: A9X1D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: cytoskeleton

9555:PAQR6
gene id: 9555:PAQR6
uniprot id: A0A096N1B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9555:PDCL
gene id: 9555:PDCL
uniprot id: A0A2I3LQA2
names: Similarity
messages: Belongs to the phosducin family.

9555:CA12
gene id: 9555:CA12
uniprot id: A0A096NMA4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9555:UGT2B39
gene id: 9555:UGT2B39
uniprot id: D2SMM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:NDST2
gene id: 9555:NDST2
uniprot id: A0A096P4L1
uniprot id: A0A8I5N906
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9555:CAVIN3
gene id: 9555:CAVIN3
uniprot id: A0A096N4Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9555:XK
gene id: 9555:XK
uniprot id: A0A096N4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9555:ZNF280B
gene id: 9555:ZNF280B
uniprot id: A0A096NCA4
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9555:PARK7
gene id: 9555:PARK7
uniprot id: A0A2I3M4I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9555:SEMA3C
gene id: 9555:SEMA3C
uniprot id: A0A096MZM1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:FCER1G
gene id: 9555:FCER1G
uniprot id: A0A096MXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9555:SSTR3
gene id: 9555:SSTR3
uniprot id: A0A096NJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TIGD3
gene id: 9555:TIGD3
uniprot id: A0A096MR01
names: Subcellular Location Annotation
messages: Nucleus

9555:EIF3L
gene id: 9555:EIF3L
uniprot id: A0A096NJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9555:HADHB
gene id: 9555:HADHB
uniprot id: A0A096NW84
uniprot id: A0A2I3MBU6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9555:ABL2
gene id: 9555:ABL2
uniprot id: A0A096MQ99
uniprot id: A0A096MZF3
uniprot id: A0A2I3LLL1
uniprot id: A0A2I3MIM0
uniprot id: A0A2I3MNM5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:LOC101017122
gene id: 9555:LOC101017122
uniprot id: A0A096NFB0
uniprot id: A0A2I3MDY9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9555:NBN
gene id: 9555:NBN
uniprot id: A0A096NPV8
uniprot id: E5FGM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9555:OR51G2
gene id: 9555:OR51G2
uniprot id: A9L8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ARMC1
gene id: 9555:ARMC1
uniprot id: A0A2I3LNK3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9555:RCL1
gene id: 9555:RCL1
uniprot id: A0A096P1M2
uniprot id: A0A8I5NSN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9555:NUMB
gene id: 9555:NUMB
uniprot id: A0A096NVZ0
uniprot id: A0A2I3LMU2
uniprot id: A0A2I3MUA0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9555:SLC4A7
gene id: 9555:SLC4A7
uniprot id: A0A096N3I4
uniprot id: A0A2I3MYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9555:RAB9A
gene id: 9555:RAB9A
uniprot id: A0A096MQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9555:TSC22D2
gene id: 9555:TSC22D2
uniprot id: A0A096N1L4
uniprot id: A0A2I3M807
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9555:ZFYVE27
gene id: 9555:ZFYVE27
uniprot id: A0A2I3LW89
uniprot id: A0A2I3N4E1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9555:DGAT1
gene id: 9555:DGAT1
uniprot id: A0A096MYX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9555:F10
gene id: 9555:F10
uniprot id: A9X172
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:PAF1
gene id: 9555:PAF1
uniprot id: A0A0A0MX55
names: Similarity
messages: Belongs to the PAF1 family.

9555:FTHL17
gene id: 9555:FTHL17
uniprot id: A0A2I3LIN7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9555:MTMR9
gene id: 9555:MTMR9
uniprot id: A0A096MTA4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9555:PGLS
gene id: 9555:PGLS
uniprot id: A0A0A0MVM5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9555:ORAI2
gene id: 9555:ORAI2
uniprot id: A0A8I5R7V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9555:B4GALT4
gene id: 9555:B4GALT4
uniprot id: A0A096N3C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9555:INPP4B
gene id: 9555:INPP4B
uniprot id: A0A096N8Z7
uniprot id: A0A096NBQ5
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9555:CMAS
gene id: 9555:CMAS
uniprot id: A0A096MYY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9555:ARFGEF2
gene id: 9555:ARFGEF2
uniprot id: A0A2I3MGI6
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9555:RNF8
gene id: 9555:RNF8
uniprot id: A0A096NHV0
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9555:VCP
gene id: 9555:VCP
uniprot id: A0A096P194
names: Similarity
messages: Belongs to the AAA ATPase family.

9555:EXOC6
gene id: 9555:EXOC6
uniprot id: A0A2I3LC69
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9555:SLC29A3
gene id: 9555:SLC29A3
uniprot id: A0A096P4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9555:VPS54
gene id: 9555:VPS54
uniprot id: A0A096P057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9555:ITGB3
gene id: 9555:ITGB3
uniprot id: A0A2I3MIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9555:WNT16
gene id: 9555:WNT16
uniprot id: A0A096N804
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:CD14
gene id: 9555:CD14
uniprot id: A0A096MKV9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9555:LETM1
gene id: 9555:LETM1
uniprot id: A0A096NFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9555:GDPGP1
gene id: 9555:GDPGP1
uniprot id: A0A096N5C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9555:PSMC4
gene id: 9555:PSMC4
uniprot id: A0A0A0MV92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9555:HMGA1
gene id: 9555:HMGA1
uniprot id: A0A8I5NQB5
uniprot id: A0A8I5R1Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
messages: Interacts with HIPK2.
messages: Nucleus

9555:VPS8
gene id: 9555:VPS8
uniprot id: A0A096NQ70
uniprot id: A0A2I3LFH9
names: Similarity
messages: Belongs to the VPS8 family.

9555:TBX22
gene id: 9555:TBX22
uniprot id: A0A096MUJ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:LOC101021285
gene id: 9555:LOC101021285
uniprot id: A0A096P3X8
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9555:BTD
gene id: 9555:BTD
uniprot id: A0A096NG45
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9555:PSMC3
gene id: 9555:PSMC3
uniprot id: A0A096N8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9555:TM4SF19
gene id: 9555:TM4SF19
uniprot id: A0A096N397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9555:KLC1
gene id: 9555:KLC1
uniprot id: A0A096NJZ3
uniprot id: A0A2I3LN97
uniprot id: A0A2I3LUC3
uniprot id: A0A2I3MD17
uniprot id: A0A2I3MUI4
uniprot id: A0A2I3N524
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9555:MYO1F
gene id: 9555:MYO1F
uniprot id: A0A0A0MWG4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:CYGB
gene id: 9555:CYGB
uniprot id: A0A096NT41
names: Similarity
messages: Belongs to the globin family.

9555:CXCL13
gene id: 9555:CXCL13
uniprot id: A0A8I5NEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:GOLT1B
gene id: 9555:GOLT1B
uniprot id: A0A096NBK9
uniprot id: A0A2I3LKE9
uniprot id: A0A2I3N1K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9555:KCNB2
gene id: 9555:KCNB2
uniprot id: A0A096MKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

9555:SLC22A2
gene id: 9555:SLC22A2
uniprot id: A0A096NZX4
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9555:PPIB
gene id: 9555:PPIB
uniprot id: A0A8I5R512
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:PTDSS1
gene id: 9555:PTDSS1
uniprot id: A0A096NAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:GSK3A
gene id: 9555:GSK3A
uniprot id: A0A096N746
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9555:TNFRSF11A
gene id: 9555:TNFRSF11A
uniprot id: A0A096N6C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ETS2
gene id: 9555:ETS2
uniprot id: A0A096NJ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9555:MIXL1
gene id: 9555:MIXL1
uniprot id: A0A096N7V7
names: Subcellular Location Annotation
messages: Nucleus

9555:RASGRP2
gene id: 9555:RASGRP2
uniprot id: A0A096MMC9
uniprot id: B0CM63
names: Similarity
messages: Belongs to the RASGRP family.

9555:ELMO2
gene id: 9555:ELMO2
uniprot id: A0A096NLX7
uniprot id: A0A2I3LXB0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9555:MLLT11
gene id: 9555:MLLT11
uniprot id: A0A2I3MZ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9555:ASZ1
gene id: 9555:ASZ1
uniprot id: Q8WMX7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9555:PROKR2
gene id: 9555:PROKR2
uniprot id: A0A096NVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:TRIM23
gene id: 9555:TRIM23
uniprot id: A0A096MKZ5
names: Subcellular Location Annotation
messages: Nucleus

9555:IL13
gene id: 9555:IL13
uniprot id: A9CB12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9555:LOC101019045
gene id: 9555:LOC101019045
uniprot id: A0A096N1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9555:RGN
gene id: 9555:RGN
uniprot id: A0A096MLV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

9555:CD47
gene id: 9555:CD47
uniprot id: A0A096NQZ6
uniprot id: A0A2I3LIZ4
uniprot id: A0A8I5NS18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:RETN
gene id: 9555:RETN
uniprot id: A0A0A0MU90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9555:MBOAT7
gene id: 9555:MBOAT7
uniprot id: A9L911
names: Subcellular Location Annotation
messages: Membrane

9555:MAGT1
gene id: 9555:MAGT1
uniprot id: A0A096NC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:PAICS
gene id: 9555:PAICS
uniprot id: A0A096N8T6
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9555:RAD50
gene id: 9555:RAD50
uniprot id: A9CB11
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9555:S100B
gene id: 9555:S100B
uniprot id: A0A8I5N4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9555:HSPB6
gene id: 9555:HSPB6
uniprot id: A0A0A0MXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9555:PROK2
gene id: 9555:PROK2
uniprot id: A0A2I3LKN9
uniprot id: A0A2I3NFK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9555:GYS2
gene id: 9555:GYS2
uniprot id: A0A096N5V0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9555:NDUFAF7
gene id: 9555:NDUFAF7
uniprot id: A0A096NDN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9555:MRPL49
gene id: 9555:MRPL49
uniprot id: A0A096N123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9555:SMG9
gene id: 9555:SMG9
uniprot id: A0A0A0MV12
uniprot id: A0A2I3N0T6
names: Similarity
messages: Belongs to the SMG9 family.

9555:MAP3K8
gene id: 9555:MAP3K8
uniprot id: A0A096P402
uniprot id: A0A2I3LEE9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9555:KLC2
gene id: 9555:KLC2
uniprot id: A0A096N551
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9555:TSPAN2
gene id: 9555:TSPAN2
uniprot id: A0A096NCJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:MCF2L
gene id: 9555:MCF2L
uniprot id: A0A096MZZ9
uniprot id: A0A2I3M995
uniprot id: A0A2I3NBM1
names: Subcellular Location Annotation
messages: Cytoplasm

9555:BCKDHA
gene id: 9555:BCKDHA
uniprot id: A0A096NBB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9555:TLE3
gene id: 9555:TLE3
uniprot id: A0A096NMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9555:PIK3CB
gene id: 9555:PIK3CB
uniprot id: A0A096NG14
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9555:CENPT
gene id: 9555:CENPT
uniprot id: A0A096NBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9555:COX3
gene id: 9555:COX3
uniprot id: K9MUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

9555:SEC61A1
gene id: 9555:SEC61A1
uniprot id: A0A096MM20
uniprot id: A0A2I3MXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SLC8A3
gene id: 9555:SLC8A3
uniprot id: A0A096NVV2
uniprot id: A0A2I3LFR2
uniprot id: A0A8I5N0A9
uniprot id: A0A8I5N7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9555:POMGNT1
gene id: 9555:POMGNT1
uniprot id: A0A096NR32
uniprot id: A0A2I3LLH4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9555:ALOX12
gene id: 9555:ALOX12
uniprot id: A0A096P2L8
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CPA1
gene id: 9555:CPA1
uniprot id: A0A2I3MRR1
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:UBQLN2
gene id: 9555:UBQLN2
uniprot id: A0A096N9W1
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9555:CLDN12
gene id: 9555:CLDN12
uniprot id: B0CM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9555:CD8A
gene id: 9555:CD8A
uniprot id: A0A096N5A0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:NFKB2
gene id: 9555:NFKB2
uniprot id: A0A096P6E6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:VBP1
gene id: 9555:VBP1
uniprot id: A0A2I3MSI9
uniprot id: A0A2I3N7T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9555:RND3
gene id: 9555:RND3
uniprot id: A0A096NSN7
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9555:NECAP2
gene id: 9555:NECAP2
uniprot id: A0A096MU17
uniprot id: A0A2I3LDM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9555:CSTF3
gene id: 9555:CSTF3
uniprot id: A0A096MY39
uniprot id: A0A2I3NAD4
names: Subcellular Location Annotation
messages: Nucleus

9555:POLR2B
gene id: 9555:POLR2B
uniprot id: A0A096NEY4
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9555:SERPINB6
gene id: 9555:SERPINB6
uniprot id: A0A8I5NST9
names: Similarity
messages: Belongs to the serpin family.

9555:SEC22A
gene id: 9555:SEC22A
uniprot id: A0A096NDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9555:MUL1
gene id: 9555:MUL1
uniprot id: A0A2I3M4P6
names: Subcellular Location Annotation
messages: Membrane

9555:HOXB7
gene id: 9555:HOXB7
uniprot id: A0A8I5N170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:FAM49A
gene id: 9555:FAM49A
uniprot id: A0A096NR07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9555:TRIM5
gene id: 9555:TRIM5
uniprot id: A0A096MZZ7
uniprot id: A7U0P5
uniprot id: Q5D7J2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation (By similarity).
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
messages: Cytoplasm
messages: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
messages: Nucleus
messages: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity. The coiled coil domain is important for higher order multimerization by promoting the initial dimerization.
messages: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (By similarity).
messages: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.

9555:KAT5
gene id: 9555:KAT5
uniprot id: A0A096MZF0
uniprot id: A0A2I3LEQ6
uniprot id: A0A2I3ME21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9555:IL4
gene id: 9555:IL4
uniprot id: Q865Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9555:TOR3A
gene id: 9555:TOR3A
uniprot id: A0A096N1Q9
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9555:PI4K2A
gene id: 9555:PI4K2A
uniprot id: A0A096P619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9555:VAMP2
gene id: 9555:VAMP2
uniprot id: A0A2I3N830
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

9555:SNX17
gene id: 9555:SNX17
uniprot id: A0A096NW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9555:ZP3
gene id: 9555:ZP3
uniprot id: A0A8I5MUW0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Membrane
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9555:USP15
gene id: 9555:USP15
uniprot id: A0A096MWR8
uniprot id: A0A2I3M5A9
uniprot id: A0A2I3N365
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

9555:CLDND2
gene id: 9555:CLDND2
uniprot id: A0A0A0MVL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9555:SDHAF1
gene id: 9555:SDHAF1
uniprot id: A0A0A0MVB5
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9555:CENPA
gene id: 9555:CENPA
uniprot id: A0A096NYQ3
names: Similarity
messages: Belongs to the histone H3 family.

9555:F2RL2
gene id: 9555:F2RL2
uniprot id: A0A096NP45
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:LOC101000499
gene id: 9555:LOC101000499
uniprot id: A0A096NEC7
names: Subcellular Location Annotation
messages: Nucleus

9555:ALG3
gene id: 9555:ALG3
uniprot id: A0A2I3M2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:MYLK4
gene id: 9555:MYLK4
uniprot id: A0A096NKJ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:MTIF2
gene id: 9555:MTIF2
uniprot id: A0A096NGV9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9555:LOC101014662
gene id: 9555:LOC101014662
uniprot id: A0A2I3MH43
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9555:FAXC
gene id: 9555:FAXC
uniprot id: A0A096NUH8
uniprot id: A0A2I3MCA6
names: Similarity
messages: Belongs to the FAX family.

9555:LOC101011798
gene id: 9555:LOC101011798
uniprot id: A0A2I3M855
uniprot id: A0A2I3N659
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9555:DDR2
gene id: 9555:DDR2
uniprot id: A0A096MUC1
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101026205
gene id: 9555:LOC101026205
uniprot id: A0A096N467
uniprot id: A0A2I3MMJ4
names: Similarity
messages: Belongs to the CD99 family.

9555:CHM
gene id: 9555:CHM
uniprot id: A0A8I5NXN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9555:IGF1
gene id: 9555:IGF1
uniprot id: A0A096NGA2
uniprot id: A0A2I3MJX9
uniprot id: A0A2I3N9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9555:TMEM106A
gene id: 9555:TMEM106A
uniprot id: A0A096P5X5
names: Similarity
messages: Belongs to the TMEM106 family.

9555:CLASP1
gene id: 9555:CLASP1
uniprot id: A0A096NF76
uniprot id: A0A2I3N734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

9555:SLC6A18
gene id: 9555:SLC6A18
uniprot id: A0A096MKP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9555:COQ10B
gene id: 9555:COQ10B
uniprot id: A0A2I3LCE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9555:MTCH1
gene id: 9555:MTCH1
uniprot id: A0A096NHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:EXTL1
gene id: 9555:EXTL1
uniprot id: A0A096NFK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SDHAF3
gene id: 9555:SDHAF3
uniprot id: A0A096MU49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9555:JAGN1
gene id: 9555:JAGN1
uniprot id: A0A2I3LEM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:HSPD1
gene id: 9555:HSPD1
uniprot id: A0A2I3MCE5
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9555:KIF6
gene id: 9555:KIF6
uniprot id: A0A096NHZ9
uniprot id: A0A2I3LQJ5
uniprot id: A0A2I3LQU8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:MBOAT4
gene id: 9555:MBOAT4
uniprot id: A0A096N220
names: Subcellular Location Annotation
messages: Membrane

9555:FAM3C
gene id: 9555:FAM3C
uniprot id: A0A096MY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9555:CFTR
gene id: 9555:CFTR
uniprot id: A0A096N2J6
uniprot id: A0A2I3MLR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Recycling endosome membrane

9555:TDRD3
gene id: 9555:TDRD3
uniprot id: A0A096NYY4
uniprot id: A0A2I3N9R7
uniprot id: A0A8I5NIV1
uniprot id: A0A8I5NJ32
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9555:OR52A5
gene id: 9555:OR52A5
uniprot id: A9L8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:KCNK17
gene id: 9555:KCNK17
uniprot id: A0A096NHZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:ADAMTS9
gene id: 9555:ADAMTS9
uniprot id: A0A096NA48
uniprot id: A0A2I3MXS1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:DNMT3L
gene id: 9555:DNMT3L
uniprot id: A0A096NIG6
names: Subcellular Location Annotation
messages: Nucleus

9555:HTR1A
gene id: 9555:HTR1A
uniprot id: A0A096MRD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9555:LRP12
gene id: 9555:LRP12
uniprot id: A0A096NPC7
uniprot id: A0A2I3MR40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:BRF2
gene id: 9555:BRF2
uniprot id: A0A096MUY5
names: Similarity
messages: Belongs to the TFIIB family.

9555:PPP1R1A
gene id: 9555:PPP1R1A
uniprot id: A0A096NAT9
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9555:HACD2
gene id: 9555:HACD2
uniprot id: A0A096NFP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:LIMD1
gene id: 9555:LIMD1
uniprot id: A0A096N113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

9555:PSMF1
gene id: 9555:PSMF1
uniprot id: A0A8I5P2Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9555:RPS27
gene id: 9555:RPS27
uniprot id: A0A2I3NEH1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9555:ATP1B3
gene id: 9555:ATP1B3
uniprot id: A0A096N415
uniprot id: A0A2I3LCU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9555:CLDN15
gene id: 9555:CLDN15
uniprot id: A0A096NR54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:MCU
gene id: 9555:MCU
uniprot id: A0A096P4Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9555:SLC22A8
gene id: 9555:SLC22A8
uniprot id: A0A096NDC7
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9555:CCNDBP1
gene id: 9555:CCNDBP1
uniprot id: A0A096NSP4
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9555:MMP13
gene id: 9555:MMP13
uniprot id: A0A2I3LXK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9555:ASIC1
gene id: 9555:ASIC1
uniprot id: A0A2I3NAH5
names: Subcellular Location Annotation
messages: Membrane

9555:CCNT2
gene id: 9555:CCNT2
uniprot id: A0A096NXX6
uniprot id: A0A096P040
names: Similarity
messages: Belongs to the cyclin family.

9555:CSTF2
gene id: 9555:CSTF2
uniprot id: A0A096NCS8
uniprot id: A0A2I3MYS5
uniprot id: A0A2I3NGR2
names: Subcellular Location Annotation
messages: Nucleus

9555:GADD45B
gene id: 9555:GADD45B
uniprot id: A0A0A0MX24
names: Similarity
messages: Belongs to the GADD45 family.

9555:RIBC1
gene id: 9555:RIBC1
uniprot id: A0A096MMZ9
uniprot id: A0A096MZR5
names: Similarity
messages: Belongs to the RIB43A family.

9555:YWHAH
gene id: 9555:YWHAH
uniprot id: A9CB38
names: Similarity
messages: Belongs to the 14-3-3 family.

9555:SLC29A2
gene id: 9555:SLC29A2
uniprot id: A0A096NC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9555:TRARG1
gene id: 9555:TRARG1
uniprot id: A0A2I3MED7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9555:GLYAT
gene id: 9555:GLYAT
uniprot id: A0A096MPA2
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9555:MSMB
gene id: 9555:MSMB
uniprot id: Q28767
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-microseminoprotein family.
messages: Homodimer; Interacts with PI16.
messages: Secreted

9555:SPTY2D1
gene id: 9555:SPTY2D1
uniprot id: A0A096N3G5
names: Similarity
messages: Belongs to the SPT2 family.

9555:SHCBP1L
gene id: 9555:SHCBP1L
uniprot id: A0A096P017
names: Subcellular Location Annotation
messages: spindle

9555:MRPL30
gene id: 9555:MRPL30
uniprot id: A0A2I3N1N3
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9555:SLC35D1
gene id: 9555:SLC35D1
uniprot id: A0A096MZF6
names: Subcellular Location Annotation
messages: Membrane

9555:CENPI
gene id: 9555:CENPI
uniprot id: A0A096NBD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9555:HAGH
gene id: 9555:HAGH
uniprot id: A0A096NKY1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9555:HGD
gene id: 9555:HGD
uniprot id: A0A096N3L5
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9555:FAM83A
gene id: 9555:FAM83A
uniprot id: A0A096NRJ8
names: Similarity
messages: Belongs to the FAM83 family.

9555:LTF
gene id: 9555:LTF
uniprot id: A0A096MZN6
uniprot id: A0A8I5NGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

9555:CAMP
gene id: 9555:CAMP
uniprot id: A0A096N3S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Binds to bacterial lipopolysaccharides (LPS) and has antibacterial activity. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Secreted

9555:MB
gene id: 9555:MB
uniprot id: P68084
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9555:ANAPC2
gene id: 9555:ANAPC2
uniprot id: A0A096NWP0
names: Similarity
messages: Belongs to the cullin family.

9555:ALX4
gene id: 9555:ALX4
uniprot id: A0A096N4Y9
names: Subcellular Location Annotation
messages: Nucleus

9555:PLBD1
gene id: 9555:PLBD1
uniprot id: A0A096MRC1
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9555:SIX6
gene id: 9555:SIX6
uniprot id: A0A8I5N991
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

9555:GAB3
gene id: 9555:GAB3
uniprot id: A0A096N703
names: Similarity
messages: Belongs to the GAB family.

9555:ANO10
gene id: 9555:ANO10
uniprot id: A0A096N625
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TM2D2
gene id: 9555:TM2D2
uniprot id: A0A2I3N587
names: Subcellular Location Annotation
messages: Membrane

9555:MUSK
gene id: 9555:MUSK
uniprot id: A0A2I3MV38
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TPX2
gene id: 9555:TPX2
uniprot id: A0A2I3MEM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9555:POLR2C
gene id: 9555:POLR2C
uniprot id: A0A096NIT0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9555:MANEAL
gene id: 9555:MANEAL
uniprot id: A0A096NWC3
uniprot id: A0A2I3LCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:MMP19
gene id: 9555:MMP19
uniprot id: A0A096N846
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:TEKT1
gene id: 9555:TEKT1
uniprot id: A0A8I5NDX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9555:PSMB2
gene id: 9555:PSMB2
uniprot id: A0A096MX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:NSUN6
gene id: 9555:NSUN6
uniprot id: A0A096P3N3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9555:DSP
gene id: 9555:DSP
uniprot id: A0A096NKT3
names: Subcellular Location Annotation
messages: cytoskeleton

9555:GSTO2
gene id: 9555:GSTO2
uniprot id: A0A096P6I8
uniprot id: A0A2I3LI68
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9555:LOC101014098
gene id: 9555:LOC101014098
uniprot id: A0A096MST5
uniprot id: A0A096NR31
uniprot id: A0A2I3N479
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:CHRD
gene id: 9555:CHRD
uniprot id: A0A2I3LJ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9555:HRK
gene id: 9555:HRK
uniprot id: A0A096N944
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Promotes apoptosis.

9555:LDLRAD3
gene id: 9555:LDLRAD3
uniprot id: A0A2I3LT76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CIT
gene id: 9555:CIT
uniprot id: A0A2I3LJ38
uniprot id: A0A2I3MKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9555:KCNMB1
gene id: 9555:KCNMB1
uniprot id: A0A8I5NIJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9555:CCNA2
gene id: 9555:CCNA2
uniprot id: A0A096NPY9
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9555:PPIL1
gene id: 9555:PPIL1
uniprot id: A0A8I5R0F3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:BTF3
gene id: 9555:BTF3
uniprot id: A0A096MRY2
uniprot id: A0A2I3MAR5
names: Similarity
messages: Belongs to the NAC-beta family.

9555:MTUS1
gene id: 9555:MTUS1
uniprot id: A0A2I3LIT3
uniprot id: A0A2I3MRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9555:FAM131A
gene id: 9555:FAM131A
uniprot id: A0A096N725
names: Similarity
messages: Belongs to the FAM131 family.

9555:FAAH
gene id: 9555:FAAH
uniprot id: A0A096NXR0
uniprot id: A0A2I3MQV6
names: Similarity
messages: Belongs to the amidase family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9555:CDCA7L
gene id: 9555:CDCA7L
uniprot id: A0A096MVC0
uniprot id: A0A2I3N2R6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ATG5
gene id: 9555:ATG5
uniprot id: A0A096NR43
uniprot id: A0A2I3MC73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9555:TMC8
gene id: 9555:TMC8
uniprot id: A0A096NT60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9555:SIDT2
gene id: 9555:SIDT2
uniprot id: A0A096N708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9555:RPL10
gene id: 9555:RPL10
uniprot id: A9CB60
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Ufmylated by UFL1.

9555:PHOX2A
gene id: 9555:PHOX2A
uniprot id: A0A096MYH6
names: Subcellular Location Annotation
messages: Nucleus

9555:S1PR3
gene id: 9555:S1PR3
uniprot id: A0A096NBJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:RUVBL1
gene id: 9555:RUVBL1
uniprot id: A0A2I3MHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9555:PARP11
gene id: 9555:PARP11
uniprot id: A0A096NEC0
uniprot id: A0A2I3LSH3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:B3GNT2
gene id: 9555:B3GNT2
uniprot id: A0A096N903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:CARTPT
gene id: 9555:CARTPT
uniprot id: A0A8I5N2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9555:NR0B1
gene id: 9555:NR0B1
uniprot id: A0A096MPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9555:DENND6A
gene id: 9555:DENND6A
uniprot id: A0A096NGP4
uniprot id: A0A2I3LKT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9555:H1-4
gene id: 9555:H1-4
uniprot id: A0A096NEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9555:WNT3
gene id: 9555:WNT3
uniprot id: A0A2I3MQZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:RPS11
gene id: 9555:RPS11
uniprot id: A0A096MQQ2
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9555:MED22
gene id: 9555:MED22
uniprot id: A0A8I5NPU7
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9555:VPS13A
gene id: 9555:VPS13A
uniprot id: A0A096P1U1
uniprot id: A0A096P1U2
uniprot id: A0A2I3M5T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9555:CCR10
gene id: 9555:CCR10
uniprot id: A0A096P5U6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:NIT1
gene id: 9555:NIT1
uniprot id: A0A096N0T0
uniprot id: A0A2I3NBE5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9555:TMPO
gene id: 9555:TMPO
uniprot id: A0A096MXZ8
uniprot id: A0A096N0F2
uniprot id: A0A2I3LG24
uniprot id: A0A2I3N9G6
names: Similarity
messages: Belongs to the LEM family.

9555:PDIA6
gene id: 9555:PDIA6
uniprot id: A0A2I3LEN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9555:LECT2
gene id: 9555:LECT2
uniprot id: A0A096N9Y4
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9555:POLH
gene id: 9555:POLH
uniprot id: A0A096NIH2
names: Subcellular Location Annotation
messages: Nucleus

9555:PELI1
gene id: 9555:PELI1
uniprot id: A0A096P060
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9555:VKORC1
gene id: 9555:VKORC1
uniprot id: A0A096NHX6
uniprot id: A0A2I3M7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:ATP6V1A
gene id: 9555:ATP6V1A
uniprot id: A0A096NZ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9555:BIRC3
gene id: 9555:BIRC3
uniprot id: A0A096NYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9555:DNASE1
gene id: 9555:DNASE1
uniprot id: A0A096NLC7
names: Similarity
messages: Belongs to the DNase I family.

9555:CSTB
gene id: 9555:CSTB
uniprot id: A0A096NIL5
names: Similarity
messages: Belongs to the cystatin family.

9555:VGLL2
gene id: 9555:VGLL2
uniprot id: A0A2I3LPL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9555:PSMB4
gene id: 9555:PSMB4
uniprot id: A9X1A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9555:PRDX6
gene id: 9555:PRDX6
uniprot id: A0A096NR25
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9555:KRT32
gene id: 9555:KRT32
uniprot id: A0A096P5M0
names: Similarity
messages: Belongs to the intermediate filament family.

9555:LOXL1
gene id: 9555:LOXL1
uniprot id: A0A096NMP3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9555:TBCC
gene id: 9555:TBCC
uniprot id: A0A096MKM5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9555:B3GAT1
gene id: 9555:B3GAT1
uniprot id: A0A8I5ND89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:ATE1
gene id: 9555:ATE1
uniprot id: A0A096NU10
uniprot id: A0A2I3LCM8
uniprot id: A0A2I3LXR2
uniprot id: A0A2I3MHV6
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9555:RBM15
gene id: 9555:RBM15
uniprot id: A0A096N7X1
names: Similarity
messages: Belongs to the RRM Spen family.

9555:REM2
gene id: 9555:REM2
uniprot id: A0A096NSD3
names: Subcellular Location Annotation
messages: Cell membrane

9555:SLC25A27
gene id: 9555:SLC25A27
uniprot id: A0A096NIT1
uniprot id: A0A096NIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:MRPL41
gene id: 9555:MRPL41
uniprot id: A0A8I5N2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9555:AATF
gene id: 9555:AATF
uniprot id: A0A096P516
names: Similarity
messages: Belongs to the AATF family.

9555:URGCP
gene id: 9555:URGCP
uniprot id: A0A096NQC7
uniprot id: A0A2I3MGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9555:LLGL1
gene id: 9555:LLGL1
uniprot id: A0A096P331
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9555:DNAJB12
gene id: 9555:DNAJB12
uniprot id: A0A096P4R2
names: Subcellular Location Annotation
messages: Membrane

9555:RPL36AL
gene id: 9555:RPL36AL
uniprot id: A0A096NUT3
uniprot id: A9L948
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9555:RCAN2
gene id: 9555:RCAN2
uniprot id: A0A096NIS1
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9555:ALX3
gene id: 9555:ALX3
uniprot id: A0A096NH47
names: Subcellular Location Annotation
messages: Nucleus

9555:FAH
gene id: 9555:FAH
uniprot id: A0A096NMX9
names: Similarity
messages: Belongs to the FAH family.

9555:HNRNPA3
gene id: 9555:HNRNPA3
uniprot id: A0A096NPT5
names: Subcellular Location Annotation
messages: Nucleus

9555:DPM3
gene id: 9555:DPM3
uniprot id: A0A8I5NE21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9555:MRPS7
gene id: 9555:MRPS7
uniprot id: A0A2I3N5C1
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9555:ARSI
gene id: 9555:ARSI
uniprot id: A0A096MR34
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:NUDT12
gene id: 9555:NUDT12
uniprot id: A0A096MMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9555:CCN1
gene id: 9555:CCN1
uniprot id: A0A096NBE8
uniprot id: A0A2I3MZM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:HOXC10
gene id: 9555:HOXC10
uniprot id: A0A096NAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9555:LOC101004754
gene id: 9555:LOC101004754
uniprot id: A0A2I3LXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9555:SLC35B4
gene id: 9555:SLC35B4
uniprot id: A0A096NZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9555:SFXN4
gene id: 9555:SFXN4
uniprot id: A0A096NTX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9555:C5AR2
gene id: 9555:C5AR2
uniprot id: A0A8I5NHK5
names: Subcellular Location Annotation
messages: Cell membrane

9555:CSNK1A1
gene id: 9555:CSNK1A1
uniprot id: A0A2I3MX56
uniprot id: A0A2I3NG04
uniprot id: A0A8I5NV62
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CHUK
gene id: 9555:CHUK
uniprot id: A0A096P673
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:GPSM2
gene id: 9555:GPSM2
uniprot id: A0A096MPG4
uniprot id: A0A8I5MYB5
names: Similarity
messages: Belongs to the GPSM family.

9555:IPO4
gene id: 9555:IPO4
uniprot id: A0A096NX97
names: Subcellular Location Annotation
messages: Cytoplasm

9555:SCAMP1
gene id: 9555:SCAMP1
uniprot id: A0A2I3NGP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9555:NDUFB7
gene id: 9555:NDUFB7
uniprot id: A0A0A0MU83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9555:WBP4
gene id: 9555:WBP4
uniprot id: A0A096NYX0
names: Subcellular Location Annotation
messages: Nucleus

9555:NSG1
gene id: 9555:NSG1
uniprot id: A0A096NZE4
names: Similarity
messages: Belongs to the NSG family.

9555:SEC63
gene id: 9555:SEC63
uniprot id: A0A096MVF5
uniprot id: B0CM40
names: Subcellular Location Annotation
messages: Membrane

9555:SUPT3H
gene id: 9555:SUPT3H
uniprot id: A0A2I3LH29
names: Subcellular Location Annotation
messages: Nucleus

9555:SOAT1
gene id: 9555:SOAT1
uniprot id: A0A096MXS6
uniprot id: A0A2I3LPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:FXR2
gene id: 9555:FXR2
uniprot id: A0A096P2R4
names: Similarity
messages: Belongs to the FMR1 family.

9555:HOXC12
gene id: 9555:HOXC12
uniprot id: A0A096NC80
names: Subcellular Location Annotation
messages: Nucleus

9555:MECOM
gene id: 9555:MECOM
uniprot id: A0A2I3LD64
uniprot id: A0A8I5MYV4
names: Subcellular Location Annotation
messages: Nucleus

9555:NR1D1
gene id: 9555:NR1D1
uniprot id: A0A096P5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:DRD5
gene id: 9555:DRD5
uniprot id: A0A8I5NJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ATP6V1H
gene id: 9555:ATP6V1H
uniprot id: A0A096NBF5
uniprot id: A0A2I3M5M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9555:TM4SF5
gene id: 9555:TM4SF5
uniprot id: A0A096P2G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9555:XAGE5
gene id: 9555:XAGE5
uniprot id: A0A096MLD1
names: Similarity
messages: Belongs to the GAGE family.

9555:PTPRN
gene id: 9555:PTPRN
uniprot id: A0A096MX75
uniprot id: A0A096N891
uniprot id: B0CM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9555:OLFR604
gene id: 9555:OLFR604
uniprot id: A9L8W9
names: Subcellular Location Annotation
messages: Membrane

9555:VDAC1
gene id: 9555:VDAC1
uniprot id: A0A096NAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9555:TSPAN9
gene id: 9555:TSPAN9
uniprot id: A0A2I3N2J3
uniprot id: A0A8I5N7I4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:LOC101017841
gene id: 9555:LOC101017841
uniprot id: A0A2I3M0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9555:MCM4
gene id: 9555:MCM4
uniprot id: A0A096NDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9555:ARL8A
gene id: 9555:ARL8A
uniprot id: A0A096NPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9555:FOPNL
gene id: 9555:FOPNL
uniprot id: A0A2I3MGR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9555:KCND2
gene id: 9555:KCND2
uniprot id: A0A2I3MMS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9555:CLP1
gene id: 9555:CLP1
uniprot id: A0A2I3M413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9555:CPA4
gene id: 9555:CPA4
uniprot id: A0A096NGG9
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:AVIL
gene id: 9555:AVIL
uniprot id: A0A096N7M3
names: Similarity
messages: Belongs to the villin/gelsolin family.

9555:OPA3
gene id: 9555:OPA3
uniprot id: A0A2I3M1H0
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9555:TULP4
gene id: 9555:TULP4
uniprot id: A0A096NDK3
names: Similarity
messages: Belongs to the TUB family.

9555:GDPD3
gene id: 9555:GDPD3
uniprot id: A0A096NHR0
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9555:MRPL2
gene id: 9555:MRPL2
uniprot id: A0A096NI98
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9555:FGF20
gene id: 9555:FGF20
uniprot id: A0A8I5NDF2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9555:SLC1A1
gene id: 9555:SLC1A1
uniprot id: A0A096P1M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9555:LPAR6
gene id: 9555:LPAR6
uniprot id: A0A096N7C3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:HOXA13
gene id: 9555:HOXA13
uniprot id: A9L945
names: Subcellular Location Annotation
messages: Nucleus

9555:PREPL
gene id: 9555:PREPL
uniprot id: A0A096N3M7
names: Similarity
messages: Belongs to the peptidase S9A family.

9555:LOC101007008
gene id: 9555:LOC101007008
uniprot id: A0A096MUL1
names: Subcellular Location Annotation
messages: Membrane

9555:RPL9
gene id: 9555:RPL9
uniprot id: A0A096MVT0
uniprot id: A0A8I5R904
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9555:ST13
gene id: 9555:ST13
uniprot id: A0A096NK96
names: Similarity
messages: Belongs to the FAM10 family.

9555:GLI1
gene id: 9555:GLI1
uniprot id: A0A096MT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9555:AIG1
gene id: 9555:AIG1
uniprot id: A0A2I3M0I9
uniprot id: A0A2I3MH63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9555:MEF2A
gene id: 9555:MEF2A
uniprot id: A0A096NNE1
uniprot id: A0A2I3LQ42
uniprot id: A0A2I3N8F7
names: Subcellular Location Annotation
messages: Nucleus

9555:CBS
gene id: 9555:CBS
uniprot id: A0A096NIQ5
uniprot id: A0A096NIQ7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9555:CDC123
gene id: 9555:CDC123
uniprot id: A0A096P3F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9555:MSRB3
gene id: 9555:MSRB3
uniprot id: A0A096NBX4
uniprot id: A0A2I3N9Y8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9555:NTRK2
gene id: 9555:NTRK2
uniprot id: A0A096P1W3
uniprot id: A0A2I3MH64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9555:TACC3
gene id: 9555:TACC3
uniprot id: A0A096N0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9555:GLB1L
gene id: 9555:GLB1L
uniprot id: A0A096MV68
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9555:COQ7
gene id: 9555:COQ7
uniprot id: A0A096N6T5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9555:BOLA3
gene id: 9555:BOLA3
uniprot id: A0A2I3MW88
names: Similarity
messages: Belongs to the BolA/IbaG family.

9555:PSD2
gene id: 9555:PSD2
uniprot id: A0A096MP76
names: Subcellular Location Annotation
messages: ruffle membrane

9555:GPR152
gene id: 9555:GPR152
uniprot id: A0A096MNT9
names: Subcellular Location Annotation
messages: Cell membrane

9555:GRIN1
gene id: 9555:GRIN1
uniprot id: A0A096NWP3
uniprot id: A0A2I3LFD2
uniprot id: A0A2I3MHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:HOOK1
gene id: 9555:HOOK1
uniprot id: A0A096MXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9555:PORCN
gene id: 9555:PORCN
uniprot id: A0A096NB64
uniprot id: A0A2I3LX34
uniprot id: A0A2I3MA97
names: Subcellular Location Annotation
messages: Membrane

9555:SGSM3
gene id: 9555:SGSM3
uniprot id: A0A2I3NHU9
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9555:SFXN1
gene id: 9555:SFXN1
uniprot id: A0A096N463
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9555:RPL34
gene id: 9555:RPL34
uniprot id: A0A2I3NI01
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9555:CACNA1S
gene id: 9555:CACNA1S
uniprot id: A0A096N134
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9555:PHGDH
gene id: 9555:PHGDH
uniprot id: A0A096N8I8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9555:PTGER2
gene id: 9555:PTGER2
uniprot id: A0A096NV02
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:PDF
gene id: 9555:PDF
uniprot id: A0A096NZ09
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9555:PRTFDC1
gene id: 9555:PRTFDC1
uniprot id: A0A096P3S0
uniprot id: A0A2I3MM59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9555:LOC101022109
gene id: 9555:LOC101022109
uniprot id: A9X1D3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:MFNG
gene id: 9555:MFNG
uniprot id: A0A096NJW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:RPAIN
gene id: 9555:RPAIN
uniprot id: A0A2I3LCK1
uniprot id: A0A2I3N405
names: Subcellular Location Annotation
messages: Nucleus

9555:SLC22A1
gene id: 9555:SLC22A1
uniprot id: A0A096NZW6
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9555:CNTN1
gene id: 9555:CNTN1
uniprot id: A0A096MVI1
uniprot id: A0A2I3NE30
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9555:IGFBP2
gene id: 9555:IGFBP2
uniprot id: A0A2I3M2T5
uniprot id: A0A8I5NKC5
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:MRPS23
gene id: 9555:MRPS23
uniprot id: A0A096P4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9555:HAL
gene id: 9555:HAL
uniprot id: A0A096NCJ1
names: Similarity
messages: Belongs to the PAL/histidase family.

9555:TGFBR2
gene id: 9555:TGFBR2
uniprot id: A0A096N140
uniprot id: A0A2I3N0A2
uniprot id: A0A2I3N4N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9555:CCDC124
gene id: 9555:CCDC124
uniprot id: A0A0A0MWQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9555:ENKD1
gene id: 9555:ENKD1
uniprot id: A0A096NQ98
names: Subcellular Location Annotation
messages: cilium axoneme

9555:ECI1
gene id: 9555:ECI1
uniprot id: A0A096NL32
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9555:LHX2
gene id: 9555:LHX2
uniprot id: A0A096P0M4
names: Subcellular Location Annotation
messages: Nucleus

9555:PAX9
gene id: 9555:PAX9
uniprot id: A0A096NUN1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9555:CCDC103
gene id: 9555:CCDC103
uniprot id: A0A096P642
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9555:SUSD5
gene id: 9555:SUSD5
uniprot id: A0A096MSS1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:INHBE
gene id: 9555:INHBE
uniprot id: A0A2I3N1J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9555:LOC101023297
gene id: 9555:LOC101023297
uniprot id: A0A096P399
uniprot id: A0A2I3LFF3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9555:PRCP
gene id: 9555:PRCP
uniprot id: A0A096N232
names: Similarity
messages: Belongs to the peptidase S28 family.

9555:TMEM237
gene id: 9555:TMEM237
uniprot id: A0A096NQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9555:MAP2
gene id: 9555:MAP2
uniprot id: A0A096MXL6
uniprot id: A0A2I3MMQ7
names: Subcellular Location Annotation
messages: cytoskeleton

9555:ADA
gene id: 9555:ADA
uniprot id: A0A096NX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

9555:ZBED9
gene id: 9555:ZBED9
uniprot id: A0A096NLL7
names: Subcellular Location Annotation
messages: Nucleus

9555:OLFM4
gene id: 9555:OLFM4
uniprot id: A0A096MWK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:OR52A1
gene id: 9555:OR52A1
uniprot id: A9L8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ATP1B1
gene id: 9555:ATP1B1
uniprot id: A0A096MRZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

9555:STIM1
gene id: 9555:STIM1
uniprot id: A0A096N4F6
uniprot id: A0A2I3N7H4
uniprot id: A0A2I3ND97
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:GUCY2F
gene id: 9555:GUCY2F
uniprot id: A0A096NFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9555:SCNM1
gene id: 9555:SCNM1
uniprot id: A9X194
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9555:DTX4
gene id: 9555:DTX4
uniprot id: A0A096MW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9555:EBF2
gene id: 9555:EBF2
uniprot id: A0A096N690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9555:TMEM98
gene id: 9555:TMEM98
uniprot id: A0A096P3T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9555:SAMM50
gene id: 9555:SAMM50
uniprot id: A0A096NKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9555:HNRNPU
gene id: 9555:HNRNPU
uniprot id: A0A096NDE1
names: Subcellular Location Annotation
messages: Nucleus

9555:EXOSC7
gene id: 9555:EXOSC7
uniprot id: A0A096NDA1
uniprot id: A0A2I3LP41
names: Subcellular Location Annotation
messages: Cytoplasm

9555:MED19
gene id: 9555:MED19
uniprot id: A0A096MS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:CDH2
gene id: 9555:CDH2
uniprot id: A0A2I3M6R5
uniprot id: A0A2I3MKR0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Cell surface
messages: Membrane
messages: sarcolemma

9555:OLFML3
gene id: 9555:OLFML3
uniprot id: A0A096MKK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:ERGIC3
gene id: 9555:ERGIC3
uniprot id: A0A096NUN8
uniprot id: B0CM80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9555:PRKACB
gene id: 9555:PRKACB
uniprot id: A0A096MN53
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9555:DBT
gene id: 9555:DBT
uniprot id: A0A096N5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9555:AOC1
gene id: 9555:AOC1
uniprot id: A0A096MQK3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9555:LBX2
gene id: 9555:LBX2
uniprot id: A0A096MS65
names: Subcellular Location Annotation
messages: Nucleus

9555:HSD17B10
gene id: 9555:HSD17B10
uniprot id: A0A096NBK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:NPPC
gene id: 9555:NPPC
uniprot id: A0A096NXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9555:RAG2
gene id: 9555:RAG2
uniprot id: A0A096N3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9555:PPIL4
gene id: 9555:PPIL4
uniprot id: A0A8I5NFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:KIF24
gene id: 9555:KIF24
uniprot id: A0A2I3N0B5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:MARCHF11
gene id: 9555:MARCHF11
uniprot id: A0A096MKZ7
names: Subcellular Location Annotation
messages: Membrane

9555:PPP3CB
gene id: 9555:PPP3CB
uniprot id: A0A2I3LGU2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9555:KAT8
gene id: 9555:KAT8
uniprot id: A0A096NHX8
uniprot id: A0A2I3N8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9555:RPIA
gene id: 9555:RPIA
uniprot id: A0A096N5R7
uniprot id: A0A2I3LEH6
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9555:TXLNG
gene id: 9555:TXLNG
uniprot id: A0A096N4L1
uniprot id: A0A8I5ND34
names: Similarity
messages: Belongs to the taxilin family.

9555:TBX20
gene id: 9555:TBX20
uniprot id: A0A096N256
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:TPRA1
gene id: 9555:TPRA1
uniprot id: A0A096NGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9555:RFTN2
gene id: 9555:RFTN2
uniprot id: A0A096NDB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9555:NUDT21
gene id: 9555:NUDT21
uniprot id: A0A096NIH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9555:PEX5L
gene id: 9555:PEX5L
uniprot id: A0A096NQK9
uniprot id: A0A2I3LI74
uniprot id: A0A2I3M194
uniprot id: A0A2I3MD95
uniprot id: A0A2I3MJ45
uniprot id: A0A2I3MVF1
uniprot id: A0A2I3N1Z1
uniprot id: A0A2I3N3L5
uniprot id: A0A2I3N3Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

9555:CENPS
gene id: 9555:CENPS
uniprot id: A0A096N6R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9555:STK3
gene id: 9555:STK3
uniprot id: A0A096MTT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9555:CA2
gene id: 9555:CA2
uniprot id: A0A096NDF1
uniprot id: A0A2I3LHY3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9555:WDR55
gene id: 9555:WDR55
uniprot id: A0A096N9H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9555:BLOC1S6
gene id: 9555:BLOC1S6
uniprot id: A0A096NM00
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9555:CBX8
gene id: 9555:CBX8
uniprot id: A0A8I5N260
names: Subcellular Location Annotation
messages: Nucleus

9555:RPL13A
gene id: 9555:RPL13A
uniprot id: A0A0A0MW64
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9555:PSMD3
gene id: 9555:PSMD3
uniprot id: A0A096P5D9
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9555:C20H19orf12
gene id: 9555:C20H19orf12
uniprot id: A0A0A0MWG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9555:RPL31
gene id: 9555:RPL31
uniprot id: A0A2I3LUQ6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9555:NOXRED1
gene id: 9555:NOXRED1
uniprot id: A0A096NS91
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9555:MACIR
gene id: 9555:MACIR
uniprot id: A0A096NBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9555:PDK1
gene id: 9555:PDK1
uniprot id: A0A096NZK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9555:KCNH4
gene id: 9555:KCNH4
uniprot id: A0A096P5S0
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9555:DIPK1B
gene id: 9555:DIPK1B
uniprot id: A0A8I5NNP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9555:NIPA1
gene id: 9555:NIPA1
uniprot id: A0A096NT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9555:ACADVL
gene id: 9555:ACADVL
uniprot id: A0A096P2M9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9555:SLC16A10
gene id: 9555:SLC16A10
uniprot id: A0A096MVJ1
names: Subcellular Location Annotation
messages: Membrane

9555:LRP6
gene id: 9555:LRP6
uniprot id: A0A096N517
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:AP5M1
gene id: 9555:AP5M1
uniprot id: A0A096NVA9
uniprot id: A0A8I5NGV6
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9555:PPEF2
gene id: 9555:PPEF2
uniprot id: A0A096MYK2
names: Similarity
messages: Belongs to the PPP phosphatase family.

9555:IRF2BP1
gene id: 9555:IRF2BP1
uniprot id: A0A0A0MX84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9555:NADK
gene id: 9555:NADK
uniprot id: A0A096MPP2
names: Similarity
messages: Belongs to the NAD kinase family.

9555:MPV17L2
gene id: 9555:MPV17L2
uniprot id: A0A0A0MX81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9555:CFAP36
gene id: 9555:CFAP36
uniprot id: A0A096NP07
names: Similarity
messages: Belongs to the CFAP36 family.

9555:CARMIL1
gene id: 9555:CARMIL1
uniprot id: A0A096NLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9555:RBM10
gene id: 9555:RBM10
uniprot id: A0A096MM57
uniprot id: A0A2I3MBI0
names: Subcellular Location Annotation
messages: Nucleus

9555:SGMS2
gene id: 9555:SGMS2
uniprot id: A0A096MZC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9555:ICAM2
gene id: 9555:ICAM2
uniprot id: A0A2I3MC57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9555:SESN3
gene id: 9555:SESN3
uniprot id: A0A096N6P7
uniprot id: A0A8I5R202
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9555:BRPF3
gene id: 9555:BRPF3
uniprot id: A0A096NHR7
names: Subcellular Location Annotation
messages: Nucleus

9555:SIX2
gene id: 9555:SIX2
uniprot id: A0A096NWW4
names: Subcellular Location Annotation
messages: Nucleus

9555:TTLL1
gene id: 9555:TTLL1
uniprot id: A0A2I3MIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9555:OSBPL1A
gene id: 9555:OSBPL1A
uniprot id: A0A096NFH2
names: Similarity
messages: Belongs to the OSBP family.

9555:PARD6G
gene id: 9555:PARD6G
uniprot id: A0A096NW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9555:STEAP1
gene id: 9555:STEAP1
uniprot id: B0CM24
names: Subcellular Location Annotation
messages: Membrane

9555:PTGDS
gene id: 9555:PTGDS
uniprot id: A0A096NRQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Membrane
messages: Monomer.
messages: Nucleus membrane
messages: Rough endoplasmic reticulum
messages: perinuclear region

9555:LSM3
gene id: 9555:LSM3
uniprot id: A0A096MWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9555:MRPL36
gene id: 9555:MRPL36
uniprot id: A0A8I5P175
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9555:TMEM123
gene id: 9555:TMEM123
uniprot id: A0A096ML62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9555:MARCKS
gene id: 9555:MARCKS
uniprot id: A0A096N6A0
uniprot id: A0A8I5NF96
names: Similarity
messages: Belongs to the MARCKS family.

9555:RNPEPL1
gene id: 9555:RNPEPL1
uniprot id: A0A096N2Z8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9555:VTI1B
gene id: 9555:VTI1B
uniprot id: A0A096NVQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9555:ADAT2
gene id: 9555:ADAT2
uniprot id: A0A096N2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Cytoplasm
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9555:GINS4
gene id: 9555:GINS4
uniprot id: A0A096NZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9555:COPS8
gene id: 9555:COPS8
uniprot id: A0A096NWX9
uniprot id: A0A8I5R8Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9555:PIM2
gene id: 9555:PIM2
uniprot id: A0A096N047
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9555:ERCC5
gene id: 9555:ERCC5
uniprot id: A0A096MYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9555:ALDH7A1
gene id: 9555:ALDH7A1
uniprot id: A0A096N9I6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:GALNS
gene id: 9555:GALNS
uniprot id: A0A096NWZ8
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:CST9L
gene id: 9555:CST9L
uniprot id: A0A096NVT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9555:ATP1A4
gene id: 9555:ATP1A4
uniprot id: A0A096NZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9555:KYNU
gene id: 9555:KYNU
uniprot id: A0A096NSL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101013677
gene id: 9555:LOC101013677
uniprot id: A0A096MPD3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:AKT1
gene id: 9555:AKT1
uniprot id: A0A096NK32
uniprot id: A0A2I3N0A6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9555:ITPKB
gene id: 9555:ITPKB
uniprot id: A0A096N0Z5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:LITAF
gene id: 9555:LITAF
uniprot id: A0A2I3M8U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9555:GINS2
gene id: 9555:GINS2
uniprot id: A0A096P0A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9555:LOC100997984
gene id: 9555:LOC100997984
uniprot id: A0A8I5NBP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:PABPC4
gene id: 9555:PABPC4
uniprot id: A0A096NDE7
uniprot id: A0A2I3M327
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9555:CUTA
gene id: 9555:CUTA
uniprot id: A0A096NHI8
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9555:SLITRK3
gene id: 9555:SLITRK3
uniprot id: A0A096MMG8
names: Similarity
messages: Belongs to the SLITRK family.

9555:NPR2
gene id: 9555:NPR2
uniprot id: A0A096P169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9555:NUDT19
gene id: 9555:NUDT19
uniprot id: A0A0A0MUS1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9555:C7H15orf40
gene id: 9555:C7H15orf40
uniprot id: A0A2I3NG97
names: Similarity
messages: Belongs to the UPF0235 family.

9555:HOXB9
gene id: 9555:HOXB9
uniprot id: A0A096P431
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9555:MFAP3L
gene id: 9555:MFAP3L
uniprot id: A0A096NWD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:DERL3
gene id: 9555:DERL3
uniprot id: A0A8I5NLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9555:RASSF5
gene id: 9555:RASSF5
uniprot id: A0A096MYD7
names: Subcellular Location Annotation
messages: cytoskeleton

9555:EXOSC8
gene id: 9555:EXOSC8
uniprot id: A0A096MWY6
names: Subcellular Location Annotation
messages: Cytoplasm

9555:LMOD2
gene id: 9555:LMOD2
uniprot id: A0A096N0H1
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9555:E2F5
gene id: 9555:E2F5
uniprot id: A0A096MNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:MAST4
gene id: 9555:MAST4
uniprot id: A0A096MYL2
uniprot id: A0A2I3LTK6
uniprot id: A0A2I3N4J0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9555:ARG1
gene id: 9555:ARG1
uniprot id: A0A096P063
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9555:BTDC
gene id: 9555:BTDC
uniprot id: B6ULW6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: BTD-4 has antimicrobial activity against the Gram-negative bacterium E.coli ML35, the Gram-positive bacterium S.aureus 502a, and the fungus C.albicans 16820.
messages: BTD-4 is a cyclic heterodimer composed of subunits A and C; disulfide-linked.
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic peptide with subunit A (BTD-4). An additional intersubunit disulfide bond is formed.

9555:FOXR1
gene id: 9555:FOXR1
uniprot id: A0A096N8F6
names: Subcellular Location Annotation
messages: Nucleus

9555:CD79A
gene id: 9555:CD79A
uniprot id: A0A0A0MU29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:SLC18A3
gene id: 9555:SLC18A3
uniprot id: A0A096N6N1
names: Subcellular Location Annotation
messages: Membrane

9555:COQ8B
gene id: 9555:COQ8B
uniprot id: A0A0A0MVT6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9555:SERPINB12
gene id: 9555:SERPINB12
uniprot id: A9RA89
names: Similarity
messages: Belongs to the serpin family.

9555:ACOT8
gene id: 9555:ACOT8
uniprot id: A0A096NX31
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9555:TSR2
gene id: 9555:TSR2
uniprot id: A0A096MN80
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9555:MBP
gene id: 9555:MBP
uniprot id: A0A096N9D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9555:LLGL2
gene id: 9555:LLGL2
uniprot id: A0A096NSW1
uniprot id: A0A2I3LQV5
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9555:PAPSS1
gene id: 9555:PAPSS1
uniprot id: A0A096N6Y3
uniprot id: A0A2I3MNZ8
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9555:FGFR2
gene id: 9555:FGFR2
uniprot id: A0A2I3LIL7
uniprot id: A0A2I3LY86
uniprot id: A0A2I3NGK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9555:APOBEC3G
gene id: 9555:APOBEC3G
uniprot id: M1GNL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9555:GTDC1
gene id: 9555:GTDC1
uniprot id: A0A2I3LUP1
uniprot id: A0A2I3LWK0
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9555:NR1I3
gene id: 9555:NR1I3
uniprot id: A0A096N2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:DCBLD2
gene id: 9555:DCBLD2
uniprot id: A0A096NXL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:VAMP5
gene id: 9555:VAMP5
uniprot id: A0A096NZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9555:EFNB1
gene id: 9555:EFNB1
uniprot id: A0A096MXI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ZNF24
gene id: 9555:ZNF24
uniprot id: A0A096N8R3
names: Subcellular Location Annotation
messages: Nucleus

9555:MANBA
gene id: 9555:MANBA
uniprot id: A0A096MS94
uniprot id: A0A2I3M401
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9555:IRF1
gene id: 9555:IRF1
uniprot id: A9CB09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:IMP3
gene id: 9555:IMP3
uniprot id: A0A096NB33
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9555:HRH1
gene id: 9555:HRH1
uniprot id: A0A2I3LV21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:CHRDL2
gene id: 9555:CHRDL2
uniprot id: A0A096NCH7
names: Subcellular Location Annotation
messages: Secreted

9555:PIGN
gene id: 9555:PIGN
uniprot id: A0A096ML07
uniprot id: A0A096N060
uniprot id: A0A2I3M9Q5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TAF11
gene id: 9555:TAF11
uniprot id: A0A096NHM4
uniprot id: A0A8I5NEF4
names: Similarity
messages: Belongs to the TAF11 family.

9555:TMEM184A
gene id: 9555:TMEM184A
uniprot id: A0A096NSI6
uniprot id: A0A8I5N993
names: Subcellular Location Annotation
messages: Membrane

9555:STX18
gene id: 9555:STX18
uniprot id: A0A8I5N464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9555:KRT78
gene id: 9555:KRT78
uniprot id: A0A096N4V7
names: Similarity
messages: Belongs to the intermediate filament family.

9555:NKG7
gene id: 9555:NKG7
uniprot id: A0A0A0MXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9555:ATG4D
gene id: 9555:ATG4D
uniprot id: A0A0A0MUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9555:MBD4
gene id: 9555:MBD4
uniprot id: A0A8I5NCH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

9555:C5AR1
gene id: 9555:C5AR1
uniprot id: A0A2I3M3B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9555:SF3A1
gene id: 9555:SF3A1
uniprot id: A0A096NJG8
names: Subcellular Location Annotation
messages: Nucleus

9555:IAH1
gene id: 9555:IAH1
uniprot id: A0A096NIV5
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9555:NKX3-2
gene id: 9555:NKX3-2
uniprot id: A0A8I5NS89
names: Subcellular Location Annotation
messages: Nucleus

9555:C19H18orf32
gene id: 9555:C19H18orf32
uniprot id: A0A8I5P4I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9555:MAML3
gene id: 9555:MAML3
uniprot id: A0A096MQM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9555:GOLM1
gene id: 9555:GOLM1
uniprot id: A0A096P1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9555:ATP2B1
gene id: 9555:ATP2B1
uniprot id: A0A096MLH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: synaptic vesicle membrane

9555:VPS33A
gene id: 9555:VPS33A
uniprot id: A0A096NFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9555:TRAPPC3
gene id: 9555:TRAPPC3
uniprot id: A0A096N7N5
uniprot id: A0A2I3N4V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9555:SLC7A9
gene id: 9555:SLC7A9
uniprot id: A0A0A0MW31
names: Subcellular Location Annotation
messages: Membrane

9555:PHC3
gene id: 9555:PHC3
uniprot id: A0A096MT25
uniprot id: A0A2I3MT48
names: Subcellular Location Annotation
messages: Nucleus

9555:DMRT2
gene id: 9555:DMRT2
uniprot id: A0A2I3NBM4
uniprot id: A0A8I5NW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9555:PRPS2
gene id: 9555:PRPS2
uniprot id: A0A096MNC3
uniprot id: A0A2I3M8Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9555:GDI2
gene id: 9555:GDI2
uniprot id: A0A2I3MLM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9555:ALKAL1
gene id: 9555:ALKAL1
uniprot id: A0A096N010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9555:LOC101020949
gene id: 9555:LOC101020949
uniprot id: A0A096NYD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9555:NUDT7
gene id: 9555:NUDT7
uniprot id: A0A2I3LHE7
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9555:PSMB3
gene id: 9555:PSMB3
uniprot id: A0A096P574
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:FKBP6
gene id: 9555:FKBP6
uniprot id: A0A096NRF5
uniprot id: A0A2I3M424
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

9555:SNX7
gene id: 9555:SNX7
uniprot id: A0A096MLD8
names: Similarity
messages: Belongs to the sorting nexin family.

9555:S100A6
gene id: 9555:S100A6
uniprot id: A0A096N997
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9555:FADS3
gene id: 9555:FADS3
uniprot id: B8R1J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9555:PIANP
gene id: 9555:PIANP
uniprot id: A0A096MN51
names: Subcellular Location Annotation
messages: Membrane

9555:ADAM17
gene id: 9555:ADAM17
uniprot id: A0A096NIW3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:RAF1
gene id: 9555:RAF1
uniprot id: A0A096NYS4
uniprot id: A0A2I3N2V3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9555:MAP3K9
gene id: 9555:MAP3K9
uniprot id: A0A096NVW0
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9555:B3GALT2
gene id: 9555:B3GALT2
uniprot id: A0A096MMX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:LOC101022949
gene id: 9555:LOC101022949
uniprot id: A0A096MKX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9555:ZSCAN2
gene id: 9555:ZSCAN2
uniprot id: A0A096NN20
names: Subcellular Location Annotation
messages: Nucleus

9555:CWC25
gene id: 9555:CWC25
uniprot id: A0A096P580
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9555:NUF2
gene id: 9555:NUF2
uniprot id: A0A096N8R1
names: Similarity
messages: Belongs to the NUF2 family.

9555:MPPED2
gene id: 9555:MPPED2
uniprot id: A0A2I3LUA5
names: Similarity
messages: Belongs to the UPF0046 family.

9555:RING1
gene id: 9555:RING1
uniprot id: A0A096NHG4
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

9555:NXPH2
gene id: 9555:NXPH2
uniprot id: A0A096NSL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9555:NHSL1
gene id: 9555:NHSL1
uniprot id: A0A096NW77
uniprot id: A0A2I3MCL6
uniprot id: A0A2I3MJ35
uniprot id: A0A2I3N7A8
names: Similarity
messages: Belongs to the NHS family.

9555:PPBP
gene id: 9555:PPBP
uniprot id: A0A8I5N0B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:RBCK1
gene id: 9555:RBCK1
uniprot id: A0A096NV30
uniprot id: A0A2I3M7Q1
uniprot id: A0A2I3NAG5
names: Similarity
messages: Belongs to the RBR family.

9555:SRM
gene id: 9555:SRM
uniprot id: A0A096NPX7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9555:RC3H1
gene id: 9555:RC3H1
uniprot id: A0A096MXW1
names: Subcellular Location Annotation
messages: P-body

9555:MTMR1
gene id: 9555:MTMR1
uniprot id: A0A096MQ45
uniprot id: A0A8I5QZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9555:DUSP7
gene id: 9555:DUSP7
uniprot id: A0A096MP15
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:SRMS
gene id: 9555:SRMS
uniprot id: A0A096NN60
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:SDC4
gene id: 9555:SDC4
uniprot id: A4K2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9555:MYT1L
gene id: 9555:MYT1L
uniprot id: A0A096NIK8
uniprot id: A0A2I3LNX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9555:RPL17
gene id: 9555:RPL17
uniprot id: A0A2I3LGX5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9555:CNN2
gene id: 9555:CNN2
uniprot id: A0A096MNP3
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9555:ACTG2
gene id: 9555:ACTG2
uniprot id: A0A096NZ53
names: Similarity
messages: Belongs to the actin family.

9555:LXN
gene id: 9555:LXN
uniprot id: A0A096N686
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9555:NEUROD4
gene id: 9555:NEUROD4
uniprot id: A0A096NAD7
names: Subcellular Location Annotation
messages: Nucleus

9555:SLC25A42
gene id: 9555:SLC25A42
uniprot id: A0A0A0MUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:FMNL2
gene id: 9555:FMNL2
uniprot id: A0A096NG87
names: Similarity
messages: Belongs to the formin homology family.

9555:ASPDH
gene id: 9555:ASPDH
uniprot id: A0A0A0MWW7
uniprot id: A0A8I5NW29
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9555:TNFSF15
gene id: 9555:TNFSF15
uniprot id: A0A096P0S1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:SNX1
gene id: 9555:SNX1
uniprot id: A0A096NMB4
uniprot id: A0A2I3LW04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9555:MDM2
gene id: 9555:MDM2
uniprot id: A0A2I3NF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9555:SNRPE
gene id: 9555:SNRPE
uniprot id: A0A2I3LPQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9555:CCT5
gene id: 9555:CCT5
uniprot id: A0A096MWK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9555:PTMS
gene id: 9555:PTMS
uniprot id: A0A096NXZ2
names: Similarity
messages: Belongs to the pro/parathymosin family.

9555:DDX47
gene id: 9555:DDX47
uniprot id: A0A096N6M2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9555:SNX14
gene id: 9555:SNX14
uniprot id: A0A096MXA3
names: Similarity
messages: Belongs to the sorting nexin family.

9555:KRT35
gene id: 9555:KRT35
uniprot id: A0A096P5M3
names: Similarity
messages: Belongs to the intermediate filament family.

9555:FGD1
gene id: 9555:FGD1
uniprot id: A0A096N7K7
names: Subcellular Location Annotation
messages: cytoskeleton

9555:PABPC1
gene id: 9555:PABPC1
uniprot id: A0A096N729
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9555:LOC101021773
gene id: 9555:LOC101021773
uniprot id: A0A096P5Q5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:OSGEP
gene id: 9555:OSGEP
uniprot id: A0A096NNK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9555:BICD2
gene id: 9555:BICD2
uniprot id: A0A096P241
uniprot id: A0A8I5NTK6
names: Similarity
messages: Belongs to the BicD family.

9555:MBLAC1
gene id: 9555:MBLAC1
uniprot id: A0A8I5NKR5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9555:NDUFAF4
gene id: 9555:NDUFAF4
uniprot id: A0A8I5N6Z9
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9555:FASLG
gene id: 9555:FASLG
uniprot id: A0A2I3MI81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9555:DCP1B
gene id: 9555:DCP1B
uniprot id: A0A096N0C4
names: Similarity
messages: Belongs to the DCP1 family.

9555:IL18R1
gene id: 9555:IL18R1
uniprot id: A0A096NUE8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9555:SSR1
gene id: 9555:SSR1
uniprot id: A0A2I3MSG2
uniprot id: A0A8I5MZT4
uniprot id: A0A8I5NGL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9555:ICMT
gene id: 9555:ICMT
uniprot id: A0A096NH30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PLK1
gene id: 9555:PLK1
uniprot id: A0A096NHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9555:UGT1A5A
gene id: 9555:UGT1A5A
uniprot id: Q20CL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:PANX1
gene id: 9555:PANX1
uniprot id: A0A096MWA1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9555:DSCC1
gene id: 9555:DSCC1
uniprot id: A0A096N4A1
names: Similarity
messages: Belongs to the DCC1 family.

9555:ABCC8
gene id: 9555:ABCC8
uniprot id: A0A2I3LL00
names: Subunit
messages: Interacts with KCNJ11.

9555:FAM149B1
gene id: 9555:FAM149B1
uniprot id: A0A096P4P3
names: Similarity
messages: Belongs to the FAM149 family.

9555:GPR15
gene id: 9555:GPR15
uniprot id: A0A096NA54
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:GFOD1
gene id: 9555:GFOD1
uniprot id: A0A096NL02
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9555:SLC5A12
gene id: 9555:SLC5A12
uniprot id: A0A096N3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:CTU2
gene id: 9555:CTU2
uniprot id: A0A096NWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9555:DKK4
gene id: 9555:DKK4
uniprot id: A0A096N0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9555:HOXD3
gene id: 9555:HOXD3
uniprot id: A0A096N3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:TOP3B
gene id: 9555:TOP3B
uniprot id: A0A096NSA7
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9555:LYPLA2
gene id: 9555:LYPLA2
uniprot id: A0A8I5NUP5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9555:UBE2H
gene id: 9555:UBE2H
uniprot id: A0A096MX46
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:SPDYE4
gene id: 9555:SPDYE4
uniprot id: A0A096P2V8
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9555:BTG1
gene id: 9555:BTG1
uniprot id: A0A8I5NK34
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

9555:APH1B
gene id: 9555:APH1B
uniprot id: A0A096NMA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9555:LOC101015332
gene id: 9555:LOC101015332
uniprot id: A0A096NQ36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LOC101008803
gene id: 9555:LOC101008803
uniprot id: A0A2I3LI91
names: Similarity
messages: Belongs to the MS4A family.

9555:NEK9
gene id: 9555:NEK9
uniprot id: A0A096NS50
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9555:GC
gene id: 9555:GC
uniprot id: A0A096MVE4
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9555:ABCG4
gene id: 9555:ABCG4
uniprot id: A0A2I3M380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9555:MARK3
gene id: 9555:MARK3
uniprot id: A0A096NJY2
uniprot id: A0A2I3LN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9555:ADHFE1
gene id: 9555:ADHFE1
uniprot id: A0A096N534
uniprot id: A0A8I5R0L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9555:NDRG4
gene id: 9555:NDRG4
uniprot id: A0A2I3LD24
uniprot id: A0A2I3LPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9555:XRN2
gene id: 9555:XRN2
uniprot id: A0A096NVR5
uniprot id: A0A8I5R7R6
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9555:NACC2
gene id: 9555:NACC2
uniprot id: A0A096NRT7
names: Subcellular Location Annotation
messages: Nucleus

9555:SNRPC
gene id: 9555:SNRPC
uniprot id: A0A096NHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9555:MRPL47
gene id: 9555:MRPL47
uniprot id: A0A096N724
uniprot id: A0A2I3N5C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9555:TRMT10C
gene id: 9555:TRMT10C
uniprot id: A0A8I5NTZ6
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9555:IP6K1
gene id: 9555:IP6K1
uniprot id: A0A2I3LJC3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:NKAP
gene id: 9555:NKAP
uniprot id: A0A096NP52
names: Similarity
messages: Belongs to the NKAP family.

9555:LOC101000155
gene id: 9555:LOC101000155
uniprot id: A0A2I3NDZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9555:CYLD
gene id: 9555:CYLD
uniprot id: A0A2I3MES0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9555:PCBD2
gene id: 9555:PCBD2
uniprot id: A0A2I3MVR2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9555:TSPAN31
gene id: 9555:TSPAN31
uniprot id: A0A096MKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:FOXO1
gene id: 9555:FOXO1
uniprot id: A0A096N7B8
names: Subcellular Location Annotation
messages: Nucleus

9555:GLS2
gene id: 9555:GLS2
uniprot id: A0A096NH12
names: Similarity
messages: Belongs to the glutaminase family.

9555:LOC101001307
gene id: 9555:LOC101001307
uniprot id: A0A096NMR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:LOC101014578
gene id: 9555:LOC101014578
uniprot id: A0A096NF45
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:NRCAM
gene id: 9555:NRCAM
uniprot id: A0A2I3LP58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9555:CNIH3
gene id: 9555:CNIH3
uniprot id: A0A096N3H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9555:MRFAP1
gene id: 9555:MRFAP1
uniprot id: A0A096N9G1
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9555:MICAL2
gene id: 9555:MICAL2
uniprot id: A0A2I3MTK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9555:PTK7
gene id: 9555:PTK7
uniprot id: A0A096NIB0
names: Subcellular Location Annotation
messages: Membrane

9555:PKP4
gene id: 9555:PKP4
uniprot id: A0A096NSL0
names: Similarity
messages: Belongs to the beta-catenin family.

9555:ADGRG7
gene id: 9555:ADGRG7
uniprot id: A0A096NXS3
names: Subcellular Location Annotation
messages: Membrane

9555:GDF10
gene id: 9555:GDF10
uniprot id: A0A2I3LVP1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9555:HSD17B13
gene id: 9555:HSD17B13
uniprot id: A0A8I5N2A6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:ENPP1
gene id: 9555:ENPP1
uniprot id: A9X179
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9555:KDELR2
gene id: 9555:KDELR2
uniprot id: A0A096MVF9
uniprot id: A0A2I3M3E4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ARPC4
gene id: 9555:ARPC4
uniprot id: A9L8Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9555:FAM8A1
gene id: 9555:FAM8A1
uniprot id: A0A096NL46
names: Subcellular Location Annotation
messages: Membrane

9555:PTPRB
gene id: 9555:PTPRB
uniprot id: A0A096MVZ9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9555:LOC101006632
gene id: 9555:LOC101006632
uniprot id: A0A096NLE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9555:AP1S3
gene id: 9555:AP1S3
uniprot id: A0A096N0P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9555:TGS1
gene id: 9555:TGS1
uniprot id: A0A096MYE7
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9555:KAT6B
gene id: 9555:KAT6B
uniprot id: A0A096P4J9
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9555:SH3BP5
gene id: 9555:SH3BP5
uniprot id: A0A096MKU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9555:STX3
gene id: 9555:STX3
uniprot id: A0A2I3LUE6
uniprot id: A0A2I3M9I6
uniprot id: A0A2I3MNQ4
names: Similarity
messages: Belongs to the syntaxin family.

9555:SURF4
gene id: 9555:SURF4
uniprot id: A0A096MSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

9555:HARBI1
gene id: 9555:HARBI1
uniprot id: A0A096N1S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9555:DMGDH
gene id: 9555:DMGDH
uniprot id: A0A096MVD4
names: Similarity
messages: Belongs to the GcvT family.

9555:GLRB
gene id: 9555:GLRB
uniprot id: A0A096MPS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9555:ITM2A
gene id: 9555:ITM2A
uniprot id: A0A8I5N930
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9555:HOXA11
gene id: 9555:HOXA11
uniprot id: A9L944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9555:UGDH
gene id: 9555:UGDH
uniprot id: A0A096MY79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9555:LOC101017813
gene id: 9555:LOC101017813
uniprot id: A0A8I5NQG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:NUPR1
gene id: 9555:NUPR1
uniprot id: A0A096NHT7
names: Similarity
messages: Belongs to the NUPR family.

9555:ECRG4
gene id: 9555:ECRG4
uniprot id: A0A096NCD8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9555:KCNA1
gene id: 9555:KCNA1
uniprot id: A0A096N578
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:COX5A
gene id: 9555:COX5A
uniprot id: B0VYX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9555:ALDOC
gene id: 9555:ALDOC
uniprot id: A0A096P398
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9555:CNMD
gene id: 9555:CNMD
uniprot id: A0A096N0V4
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9555:EDIL3
gene id: 9555:EDIL3
uniprot id: A0A2I3LZS3
uniprot id: A0A2I3MWI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NDUFS3
gene id: 9555:NDUFS3
uniprot id: A0A096MXZ0
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9555:PIGH
gene id: 9555:PIGH
uniprot id: A0A096NVP3
names: Similarity
messages: Belongs to the PIGH family.

9555:CCNB1
gene id: 9555:CCNB1
uniprot id: A0A096NC02
names: Similarity
messages: Belongs to the cyclin family.

9555:ZNF408
gene id: 9555:ZNF408
uniprot id: A0A2I3MV79
names: Subcellular Location Annotation
messages: Nucleus

9555:DDX21
gene id: 9555:DDX21
uniprot id: A0A096P504
uniprot id: A0A8I5P1Q9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9555:ATP1B2
gene id: 9555:ATP1B2
uniprot id: A0A096P2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9555:CCL18
gene id: 9555:CCL18
uniprot id: A0A8I5MUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:HNF4G
gene id: 9555:HNF4G
uniprot id: A0A096NFL0
uniprot id: A0A2I3M585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:LOC101004599
gene id: 9555:LOC101004599
uniprot id: A0A2I3LN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9555:TMEM208
gene id: 9555:TMEM208
uniprot id: A0A2I3LC39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9555:LOC101017906
gene id: 9555:LOC101017906
uniprot id: A0A096MSF2
names: Similarity
messages: Belongs to the calcitonin family.

9555:TMEM45A
gene id: 9555:TMEM45A
uniprot id: A0A096MYN6
uniprot id: A0A2I3MKD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9555:PPP1R12A
gene id: 9555:PPP1R12A
uniprot id: A0A096MLI4
uniprot id: A0A2I3LQF6
uniprot id: A0A8I5N5D1
uniprot id: A0A8I5N830
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9555:PCOLCE
gene id: 9555:PCOLCE
uniprot id: A0A096NNW4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:IFNAR1
gene id: 9555:IFNAR1
uniprot id: A0A096NZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9555:LOC101015199
gene id: 9555:LOC101015199
uniprot id: A0A8I5N396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:MCM7
gene id: 9555:MCM7
uniprot id: A0A096NAA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9555:LOC103883790
gene id: 9555:LOC103883790
uniprot id: A0A096NSH2
names: Similarity
messages: Belongs to the KHDC1 family.

9555:ENO1
gene id: 9555:ENO1
uniprot id: A0A096MWA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9555:DMTF1
gene id: 9555:DMTF1
uniprot id: A0A096NZY8
names: Subcellular Location Annotation
messages: Nucleus

9555:POFUT1
gene id: 9555:POFUT1
uniprot id: A0A096NUY4
uniprot id: A0A2I3LUM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9555:FAM92A
gene id: 9555:FAM92A
uniprot id: A0A2I3MP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9555:MTFR1
gene id: 9555:MTFR1
uniprot id: A0A096N8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9555:KCTD6
gene id: 9555:KCTD6
uniprot id: A0A2I3LFW4
names: Subcellular Location Annotation
messages: Cell membrane

9555:ARID5B
gene id: 9555:ARID5B
uniprot id: A0A096P557
uniprot id: A0A2I3LQE4
uniprot id: A0A2I3LUT5
names: Similarity
messages: Belongs to the ARID5B family.

9555:GTF2H4
gene id: 9555:GTF2H4
uniprot id: A0A2I3NCG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9555:PHKA2
gene id: 9555:PHKA2
uniprot id: A0A096MP99
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9555:MPP3
gene id: 9555:MPP3
uniprot id: A0A096P5Y6
names: Similarity
messages: Belongs to the MAGUK family.

9555:XDH
gene id: 9555:XDH
uniprot id: A0A096NB01
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9555:SFRP2
gene id: 9555:SFRP2
uniprot id: A0A096MRM0
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101024147
gene id: 9555:LOC101024147
uniprot id: A0A096MWJ6
uniprot id: A0A096MXE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9555:MVP
gene id: 9555:MVP
uniprot id: A0A096NMJ5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9555:SEMA3F
gene id: 9555:SEMA3F
uniprot id: A0A096MY22
uniprot id: A0A096N5L3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TTYH1
gene id: 9555:TTYH1
uniprot id: A9L920
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.

9555:PCSK2
gene id: 9555:PCSK2
uniprot id: A0A2I3LHF8
names: Similarity
messages: Belongs to the peptidase S8 family.

9555:IPO7
gene id: 9555:IPO7
uniprot id: A0A096MTM4
names: Subcellular Location Annotation
messages: Cytoplasm

9555:DZIP3
gene id: 9555:DZIP3
uniprot id: A0A096MZ48
names: Subcellular Location Annotation
messages: Cytoplasm

9555:TRMT1
gene id: 9555:TRMT1
uniprot id: A0A0A0MX33
uniprot id: A0A2I3N375
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9555:SCD
gene id: 9555:SCD
uniprot id: A0A8I5N0F1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9555:DNAJC16
gene id: 9555:DNAJC16
uniprot id: A0A096NEQ5
names: Subcellular Location Annotation
messages: Membrane

9555:ANO8
gene id: 9555:ANO8
uniprot id: A0A0A0MVP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:SLC39A2
gene id: 9555:SLC39A2
uniprot id: A0A096NNN0
names: Subcellular Location Annotation
messages: Membrane

9555:ND1
gene id: 9555:ND1
uniprot id: K9MVJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9555:SLCO1C1
gene id: 9555:SLCO1C1
uniprot id: A0A096NPQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:EEF1A1
gene id: 9555:EEF1A1
uniprot id: A9X189
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9555:DPCD
gene id: 9555:DPCD
uniprot id: A0A096P6C0
names: Similarity
messages: Belongs to the DPCD family.

9555:ND5
gene id: 9555:ND5
uniprot id: K9MVJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9555:UBE2D4
gene id: 9555:UBE2D4
uniprot id: A0A096N2Q2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:CCDC93
gene id: 9555:CCDC93
uniprot id: A9RA87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9555:CASP6
gene id: 9555:CASP6
uniprot id: A0A096N6Y2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9555:LNPEP
gene id: 9555:LNPEP
uniprot id: A0A096MYH1
names: Similarity
messages: Belongs to the peptidase M1 family.

9555:FAM13B
gene id: 9555:FAM13B
uniprot id: A0A096NB74
uniprot id: A0A2I3M1R0
uniprot id: A0A2I3N0R8
uniprot id: A0A8I5NVH1
names: Similarity
messages: Belongs to the FAM13 family.

9555:PPIA
gene id: 9555:PPIA
uniprot id: A0A286QUN3
uniprot id: P62941
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

9555:FOLR1
gene id: 9555:FOLR1
uniprot id: A0A096MMB1
names: Similarity
messages: Belongs to the folate receptor family.

9555:TRPV5
gene id: 9555:TRPV5
uniprot id: A0A096MQP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:KCNV1
gene id: 9555:KCNV1
uniprot id: A0A096N5E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9555:TMEM126B
gene id: 9555:TMEM126B
uniprot id: A0A096N4B8
names: Subcellular Location Annotation
messages: Membrane

9555:MS4A5
gene id: 9555:MS4A5
uniprot id: A0A096MPS7
names: Similarity
messages: Belongs to the MS4A family.

9555:TNFRSF8
gene id: 9555:TNFRSF8
uniprot id: A0A096NCR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NEURL2
gene id: 9555:NEURL2
uniprot id: A0A096NX28
names: Subcellular Location Annotation
messages: Cytoplasm

9555:YIF1B
gene id: 9555:YIF1B
uniprot id: A0A0A0MVY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9555:SMPD1
gene id: 9555:SMPD1
uniprot id: A0A096MN10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9555:NR2F1
gene id: 9555:NR2F1
uniprot id: A0A2I3LQB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:TUBB4A
gene id: 9555:TUBB4A
uniprot id: A0A096NWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9555:ERAL1
gene id: 9555:ERAL1
uniprot id: A0A096P3F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9555:TMTC4
gene id: 9555:TMTC4
uniprot id: A0A096N665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9555:SNX6
gene id: 9555:SNX6
uniprot id: A9L946
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9555:FCN1
gene id: 9555:FCN1
uniprot id: A0A2I3M827
names: Similarity
messages: Belongs to the ficolin lectin family.

9555:PTPN6
gene id: 9555:PTPN6
uniprot id: A0A096MMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9555:MAN2B1
gene id: 9555:MAN2B1
uniprot id: A0A0A0MXC9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9555:IL10
gene id: 9555:IL10
uniprot id: A0A8I5NT41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9555:CTNNBL1
gene id: 9555:CTNNBL1
uniprot id: A0A096NXG8
uniprot id: A0A2I3MFL4
names: Subcellular Location Annotation
messages: Nucleus

9555:STARD9
gene id: 9555:STARD9
uniprot id: A0A096NSP7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:MICAL1
gene id: 9555:MICAL1
uniprot id: A0A2I3LCJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9555:GPHB5
gene id: 9555:GPHB5
uniprot id: A0A2I3MAP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9555:WASF3
gene id: 9555:WASF3
uniprot id: A0A096N954
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9555:NAPA
gene id: 9555:NAPA
uniprot id: A0A0A0MX36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9555:ZFYVE28
gene id: 9555:ZFYVE28
uniprot id: A0A096NWB3
names: Similarity
messages: Belongs to the lst-2 family.

9555:IL21
gene id: 9555:IL21
uniprot id: A0A8I5NTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9555:VAT1L
gene id: 9555:VAT1L
uniprot id: A0A096NH62
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9555:NOTO
gene id: 9555:NOTO
uniprot id: A0A8I5NAT8
names: Subcellular Location Annotation
messages: Nucleus

9555:DZIP1L
gene id: 9555:DZIP1L
uniprot id: A0A2I3MNY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9555:MZT1
gene id: 9555:MZT1
uniprot id: A0A096MZU8
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9555:OR51B6
gene id: 9555:OR51B6
uniprot id: A9L8Y3
names: Subcellular Location Annotation
messages: Membrane

9555:DGCR6
gene id: 9555:DGCR6
uniprot id: A0A096N6U3
names: Similarity
messages: Belongs to the gonadal family.

9555:SMAD2
gene id: 9555:SMAD2
uniprot id: A0A096NP77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9555:PTPA
gene id: 9555:PTPA
uniprot id: A0A2I3LGK3
uniprot id: B0CM96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:TM9SF4
gene id: 9555:TM9SF4
uniprot id: A0A2I3MQ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9555:ST7
gene id: 9555:ST7
uniprot id: A0A2I3M010
uniprot id: A0A2I3M5X4
uniprot id: A0A2I3N8I0
uniprot id: A0M8R9
uniprot id: A0M8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9555:KCND1
gene id: 9555:KCND1
uniprot id: A0A096NPF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9555:GSC2
gene id: 9555:GSC2
uniprot id: A0A096NS11
names: Subcellular Location Annotation
messages: Nucleus

9555:OST4
gene id: 9555:OST4
uniprot id: A0A096MNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:ETFA
gene id: 9555:ETFA
uniprot id: A0A2I3MFF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9555:GSS
gene id: 9555:GSS
uniprot id: A0A096NUR3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9555:SSTR4
gene id: 9555:SSTR4
uniprot id: A0A096NVS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SYNGR4
gene id: 9555:SYNGR4
uniprot id: A0A0A0MWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9555:KCNK10
gene id: 9555:KCNK10
uniprot id: A0A096NRB4
uniprot id: A0A2I3M1S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:ZDHHC6
gene id: 9555:ZDHHC6
uniprot id: A0A096N5I5
uniprot id: A0A2I3LCU1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:TRMT5
gene id: 9555:TRMT5
uniprot id: A0A096NVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9555:CPO
gene id: 9555:CPO
uniprot id: A0A096NPD2
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:BACE1
gene id: 9555:BACE1
uniprot id: A0A2I3MIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: Secreted
messages: trans-Golgi network

9555:LRRC8A
gene id: 9555:LRRC8A
uniprot id: B0CM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9555:MRPS17
gene id: 9555:MRPS17
uniprot id: A0A8I5R0A1
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9555:PHB2
gene id: 9555:PHB2
uniprot id: A0A2I3M437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9555:RSPO3
gene id: 9555:RSPO3
uniprot id: A0A8I5NUK4
names: Similarity
messages: Belongs to the R-spondin family.

9555:IGFBP6
gene id: 9555:IGFBP6
uniprot id: A0A096N7M7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:CD53
gene id: 9555:CD53
uniprot id: A0A096N491
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:PSPC1
gene id: 9555:PSPC1
uniprot id: A0A096NAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9555:PIAS2
gene id: 9555:PIAS2
uniprot id: A0A096MTN6
uniprot id: A0A096MU31
uniprot id: A0A2I3N4D9
names: Similarity
messages: Belongs to the PIAS family.

9555:MRPL24
gene id: 9555:MRPL24
uniprot id: A0A096NQ11
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9555:NFIB
gene id: 9555:NFIB
uniprot id: A0A096P1I8
uniprot id: A0A2I3LHJ9
uniprot id: A0A2I3M5C8
uniprot id: A0A2I3MIN4
uniprot id: A0A2I3NH97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9555:CKS1B
gene id: 9555:CKS1B
uniprot id: A0A2I3LN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9555:OTUB1
gene id: 9555:OTUB1
uniprot id: A0A2I3M9H8
names: Similarity
messages: Belongs to the peptidase C65 family.

9555:FA2H
gene id: 9555:FA2H
uniprot id: A0A096MQC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:HS2ST1
gene id: 9555:HS2ST1
uniprot id: A0A8I5N5W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9555:RNF40
gene id: 9555:RNF40
uniprot id: A0A096NHV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9555:CEPT1
gene id: 9555:CEPT1
uniprot id: A0A096NH45
uniprot id: A0A2I3MUX1
uniprot id: A0A8I5R0M2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9555:SH3KBP1
gene id: 9555:SH3KBP1
uniprot id: A0A096NYA0
names: Subcellular Location Annotation
messages: focal adhesion

9555:MGST2
gene id: 9555:MGST2
uniprot id: A0A096MXG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:TAS2R38
gene id: 9555:TAS2R38
uniprot id: A0A096MKS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9555:LCA5L
gene id: 9555:LCA5L
uniprot id: B0CM36
names: Similarity
messages: Belongs to the LCA5 family.

9555:MGAT5
gene id: 9555:MGAT5
uniprot id: A0A096NZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9555:FBXO34
gene id: 9555:FBXO34
uniprot id: A0A096N5S5
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9555:IL33
gene id: 9555:IL33
uniprot id: A0A096P1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9555:BARX2
gene id: 9555:BARX2
uniprot id: A0A096NDG7
names: Subcellular Location Annotation
messages: Nucleus

9555:INKA2
gene id: 9555:INKA2
uniprot id: A0A096N1Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9555:HEXB
gene id: 9555:HEXB
uniprot id: A0A096N5T9
uniprot id: A0A2I3MDW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9555:EML2
gene id: 9555:EML2
uniprot id: A0A0A0MUS4
uniprot id: A0A2I3LHS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9555:PRDX5
gene id: 9555:PRDX5
uniprot id: A0A2I3M5Q3
uniprot id: A0A2I3MGG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9555:CCDC86
gene id: 9555:CCDC86
uniprot id: A0A096MUS3
names: Subcellular Location Annotation
messages: Nucleus

9555:CYFIP1
gene id: 9555:CYFIP1
uniprot id: A0A096NT16
uniprot id: A0A2I3MLD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9555:LOC103875614
gene id: 9555:LOC103875614
uniprot id: A0A096NBR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:RBM3
gene id: 9555:RBM3
uniprot id: A0A2I3MGL6
names: Subcellular Location Annotation
messages: Cytoplasm

9555:UROC1
gene id: 9555:UROC1
uniprot id: A0A096N3T9
names: Similarity
messages: Belongs to the urocanase family.

9555:FREM2
gene id: 9555:FREM2
uniprot id: A0A096MPR1
names: Similarity
messages: Belongs to the FRAS1 family.

9555:KMT5A
gene id: 9555:KMT5A
uniprot id: A0A096N875
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9555:GRM2
gene id: 9555:GRM2
uniprot id: A0A096NYH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9555:MANEA
gene id: 9555:MANEA
uniprot id: A0A096NW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:MMP27
gene id: 9555:MMP27
uniprot id: A0A2I3MI87
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:LACTB2
gene id: 9555:LACTB2
uniprot id: A0A096NQ45
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9555:UBE2E2
gene id: 9555:UBE2E2
uniprot id: A0A2I3LWV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:LOC101006759
gene id: 9555:LOC101006759
uniprot id: A0A096MZU2
names: Similarity
messages: Belongs to the AIDA family.

9555:AADACL4
gene id: 9555:AADACL4
uniprot id: A0A096MNX0
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9555:RPL13
gene id: 9555:RPL13
uniprot id: A0A2I3MG94
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9555:LEPROTL1
gene id: 9555:LEPROTL1
uniprot id: A0A2I3N4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9555:EEF1AKMT1
gene id: 9555:EEF1AKMT1
uniprot id: A0A096MQR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9555:E2F3
gene id: 9555:E2F3
uniprot id: A0A096NL85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:TAF6L
gene id: 9555:TAF6L
uniprot id: A0A096NDU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9555:SGCD
gene id: 9555:SGCD
uniprot id: A0A096N830
uniprot id: A0A8I5MZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9555:NEMP2
gene id: 9555:NEMP2
uniprot id: A0A8I5NFW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9555:PGBD1
gene id: 9555:PGBD1
uniprot id: A0A096NLK7
names: Subcellular Location Annotation
messages: Nucleus

9555:CIAPIN1
gene id: 9555:CIAPIN1
uniprot id: A0A096NIS3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9555:C10H2orf76
gene id: 9555:C10H2orf76
uniprot id: A0A096NH52
uniprot id: A0A8I5R4Y7
names: Similarity
messages: Belongs to the UPF0538 family.

9555:HPDL
gene id: 9555:HPDL
uniprot id: A0A8I5P0B2
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9555:KCNJ2
gene id: 9555:KCNJ2
uniprot id: A0A096MS42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane

9555:ATP6V0A1
gene id: 9555:ATP6V0A1
uniprot id: A0A096P5T1
uniprot id: A0A2I3LMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9555:PEX13
gene id: 9555:PEX13
uniprot id: A0A096NG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

9555:PELI3
gene id: 9555:PELI3
uniprot id: A0A096NXI2
uniprot id: A0A2I3MFB7
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9555:PLA2G5
gene id: 9555:PLA2G5
uniprot id: A0A096NFK6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9555:DCTN2
gene id: 9555:DCTN2
uniprot id: A0A096NXM8
uniprot id: A0A2I3LFZ8
uniprot id: A0A2I3LI75
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9555:EPHA3
gene id: 9555:EPHA3
uniprot id: A0A096N0A8
names: Subcellular Location Annotation
messages: Membrane

9555:ENTPD8
gene id: 9555:ENTPD8
uniprot id: A0A096NWM8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9555:MRFAP1L1
gene id: 9555:MRFAP1L1
uniprot id: A0A096N9G1
uniprot id: A0A8I5N0M6
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9555:NIPSNAP2
gene id: 9555:NIPSNAP2
uniprot id: A0A096NDK2
uniprot id: A0A2I3MXF9
names: Similarity
messages: Belongs to the NipSnap family.

9555:SNX31
gene id: 9555:SNX31
uniprot id: A0A096MYQ1
names: Similarity
messages: Belongs to the sorting nexin family.

9555:GEM
gene id: 9555:GEM
uniprot id: A0A096NBY6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9555:AUH
gene id: 9555:AUH
uniprot id: A0A096P224
uniprot id: A0A2I3LJP3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9555:CRYBA2
gene id: 9555:CRYBA2
uniprot id: A0A096MR79
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9555:TMEM45B
gene id: 9555:TMEM45B
uniprot id: A0A096N6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9555:TMEM151B
gene id: 9555:TMEM151B
uniprot id: A0A096NIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9555:FXN
gene id: 9555:FXN
uniprot id: A0A096P1P8
names: Similarity
messages: Belongs to the frataxin family.

9555:ACER3
gene id: 9555:ACER3
uniprot id: A0A096NB86
uniprot id: A0A8I5NK04
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:MAL2
gene id: 9555:MAL2
uniprot id: A0A096NG18
names: Subcellular Location Annotation
messages: Membrane

9555:SLC1A3
gene id: 9555:SLC1A3
uniprot id: A0A2I3LY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9555:ATP6AP1
gene id: 9555:ATP6AP1
uniprot id: A9CB63
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9555:ADK
gene id: 9555:ADK
uniprot id: A0A096P4K0
uniprot id: A0A2I3MTX9
uniprot id: A0A8I5N2Z5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9555:SLCO5A1
gene id: 9555:SLCO5A1
uniprot id: A0A096MZX1
uniprot id: A0A2I3LHS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:KHDRBS3
gene id: 9555:KHDRBS3
uniprot id: A0A096MKQ8
uniprot id: A0A8I5NQV7
names: Similarity
messages: Belongs to the KHDRBS family.

9555:PEX14
gene id: 9555:PEX14
uniprot id: A0A096NQF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9555:TLR1
gene id: 9555:TLR1
uniprot id: A0A096MLM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9555:GPD1
gene id: 9555:GPD1
uniprot id: A0A096N5Z3
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9555:TFIP11
gene id: 9555:TFIP11
uniprot id: A0A096NRG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9555:STK39
gene id: 9555:STK39
uniprot id: A0A2I3LR50
uniprot id: A0A8I5NIP1
uniprot id: A0A8I5P0F1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9555:IFI35
gene id: 9555:IFI35
uniprot id: A0A096P5W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9555:SLCO6A1
gene id: 9555:SLCO6A1
uniprot id: A0A096MMS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:SLC35C2
gene id: 9555:SLC35C2
uniprot id: A0A8I5N0Y3
names: Subcellular Location Annotation
messages: Membrane

9555:PTPRS
gene id: 9555:PTPRS
uniprot id: A0A2I3MSJ5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9555:HNRNPDL
gene id: 9555:HNRNPDL
uniprot id: A0A096MV71
uniprot id: A0A2I3MZ26
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:APH1A
gene id: 9555:APH1A
uniprot id: A0A096N930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9555:PPP2CA
gene id: 9555:PPP2CA
uniprot id: A0A096N3J6
uniprot id: A0A8I5N5B9
names: Similarity
messages: Belongs to the PPP phosphatase family.

9555:FABP2
gene id: 9555:FABP2
uniprot id: A0A096MX76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9555:SF3B1
gene id: 9555:SF3B1
uniprot id: A0A096N1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9555:LYPD6B
gene id: 9555:LYPD6B
uniprot id: A0A096NSN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:SLC35B3
gene id: 9555:SLC35B3
uniprot id: A0A8I5NIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9555:GPR1
gene id: 9555:GPR1
uniprot id: A0A096NCE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9555:SGMS1
gene id: 9555:SGMS1
uniprot id: A0A096P5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9555:CENPK
gene id: 9555:CENPK
uniprot id: A0A096N924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9555:KRT18
gene id: 9555:KRT18
uniprot id: A0A096MRQ2
uniprot id: A0A096NYX5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:USE1
gene id: 9555:USE1
uniprot id: A0A0A0MWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:APEH
gene id: 9555:APEH
uniprot id: A0A2I3MB32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

9555:CCT8L2
gene id: 9555:CCT8L2
uniprot id: A0A8I5NVN5
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

9555:ORC5
gene id: 9555:ORC5
uniprot id: A0A096NGR5
names: Subcellular Location Annotation
messages: Nucleus

9555:PSMG2
gene id: 9555:PSMG2
uniprot id: A0A2I3LY64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9555:OAT
gene id: 9555:OAT
uniprot id: A0A096NU53
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9555:ACTN1
gene id: 9555:ACTN1
uniprot id: A0A096NVR2
uniprot id: A0A2I3MIV3
names: Similarity
messages: Belongs to the alpha-actinin family.

9555:SPECC1L
gene id: 9555:SPECC1L
uniprot id: A0A2I3M623
uniprot id: A0A2I3MXG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9555:SRRD
gene id: 9555:SRRD
uniprot id: A0A096NRG3
names: Similarity
messages: Belongs to the SRR1 family.

9555:IRGC
gene id: 9555:IRGC
uniprot id: A0A0A0MVW8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9555:OXT
gene id: 9555:OXT
uniprot id: A0A096NV92
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9555:CDH11
gene id: 9555:CDH11
uniprot id: A0A096NJ47
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:PRDM5
gene id: 9555:PRDM5
uniprot id: A0A096N5L8
uniprot id: A0A2I3M8C3
uniprot id: A0A2I3MB98
uniprot id: A0A2I3N7X2
names: Subcellular Location Annotation
messages: Nucleus

9555:LALBA
gene id: 9555:LALBA
uniprot id: A0A8I5R503
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9555:DARS1
gene id: 9555:DARS1
uniprot id: A0A096MWD1
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9555:PPP2R5B
gene id: 9555:PPP2R5B
uniprot id: B0CM71
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9555:PAX6
gene id: 9555:PAX6
uniprot id: A0A096N4Y7
uniprot id: A0A2I3MV39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:ESRRG
gene id: 9555:ESRRG
uniprot id: A0A096NEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9555:ENTR1
gene id: 9555:ENTR1
uniprot id: A0A096NRS7
uniprot id: A0A2I3M5H6
names: Similarity
messages: Belongs to the ENTR1 family.

9555:GHITM
gene id: 9555:GHITM
uniprot id: A0A096NW88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9555:TSHR
gene id: 9555:TSHR
uniprot id: A0A2I3LV06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9555:NDUFS6
gene id: 9555:NDUFS6
uniprot id: A0A096N4A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

9555:SESN2
gene id: 9555:SESN2
uniprot id: A0A096NFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9555:RNF167
gene id: 9555:RNF167
uniprot id: A0A096P2I6
names: Subcellular Location Annotation
messages: Membrane

9555:ACTL7B
gene id: 9555:ACTL7B
uniprot id: A0A096NEI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9555:REEP2
gene id: 9555:REEP2
uniprot id: A0A096MZY9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:CHMP6
gene id: 9555:CHMP6
uniprot id: A0A096NTD0
names: Similarity
messages: Belongs to the SNF7 family.

9555:SBDS
gene id: 9555:SBDS
uniprot id: A0A096NY31
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9555:LCN2
gene id: 9555:LCN2
uniprot id: A0A096P1Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9555:MED21
gene id: 9555:MED21
uniprot id: A0A8I5NKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9555:GPM6B
gene id: 9555:GPM6B
uniprot id: A0A2I3LRP5
uniprot id: A0A2I3MYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9555:PLA2G4A
gene id: 9555:PLA2G4A
uniprot id: A0A096MUP7
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9555:AQP8
gene id: 9555:AQP8
uniprot id: A0A096NHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9555:LOC101019806
gene id: 9555:LOC101019806
uniprot id: A0A2I3N7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9555:PAPOLA
gene id: 9555:PAPOLA
uniprot id: A0A2I3M641
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9555:SLC2A6
gene id: 9555:SLC2A6
uniprot id: A0A096MSW4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9555:EXOC1
gene id: 9555:EXOC1
uniprot id: A0A096NDS1
uniprot id: A0A2I3NDL8
names: Similarity
messages: Belongs to the SEC3 family.

9555:SRP19
gene id: 9555:SRP19
uniprot id: A0A096NQR6
uniprot id: A0A2I3MCD6
uniprot id: A0A8I5NFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9555:CHRNG
gene id: 9555:CHRNG
uniprot id: A0A096MXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:RPL38
gene id: 9555:RPL38
uniprot id: A0A2I3LG62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9555:AMIGO1
gene id: 9555:AMIGO1
uniprot id: A0A096MMY0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9555:SH3GL2
gene id: 9555:SH3GL2
uniprot id: A0A096P1H4
uniprot id: A0A2I3MK86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9555:MCM3
gene id: 9555:MCM3
uniprot id: A0A096NJ40
uniprot id: A0A2I3MIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9555:GABRA2
gene id: 9555:GABRA2
uniprot id: A0A096NAY9
uniprot id: A0A2I3LYD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9555:LOC101015537
gene id: 9555:LOC101015537
uniprot id: A0A096ML47
uniprot id: A0A2I3MCP0
names: Similarity
messages: Belongs to the GroES chaperonin family.

9555:MTG2
gene id: 9555:MTG2
uniprot id: A0A096NND0
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9555:ST7L
gene id: 9555:ST7L
uniprot id: A0A096NBL6
uniprot id: A0A2I3LR55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9555:TGIF1
gene id: 9555:TGIF1
uniprot id: A0A096MXB7
names: Subcellular Location Annotation
messages: Nucleus

9555:GAP43
gene id: 9555:GAP43
uniprot id: A0A096N9W5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9555:CD109
gene id: 9555:CD109
uniprot id: A0A096MV51
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

9555:MB21D2
gene id: 9555:MB21D2
uniprot id: A0A096MS86
names: Similarity
messages: Belongs to the mab-21 family.

9555:LOC101026611
gene id: 9555:LOC101026611
uniprot id: A0A096MQM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:HOXB4
gene id: 9555:HOXB4
uniprot id: A0A096P424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:DONSON
gene id: 9555:DONSON
uniprot id: A9CB02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9555:NLGN1
gene id: 9555:NLGN1
uniprot id: A0A096N102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9555:POMGNT2
gene id: 9555:POMGNT2
uniprot id: A0A096NCA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:COQ5
gene id: 9555:COQ5
uniprot id: A0A096MP37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9555:SLC35E3
gene id: 9555:SLC35E3
uniprot id: A0A096N130
names: Subcellular Location Annotation
messages: Membrane

9555:AP3S1
gene id: 9555:AP3S1
uniprot id: A0A2I3LM47
uniprot id: A0A2I3M0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9555:STX1B
gene id: 9555:STX1B
uniprot id: A0A096NHX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9555:RPS19
gene id: 9555:RPS19
uniprot id: A0A096N169
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9555:SPOCK2
gene id: 9555:SPOCK2
uniprot id: A0A096P4S0
uniprot id: A0A8I5NCS3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SARM1
gene id: 9555:SARM1
uniprot id: A0A096P391
names: Similarity
messages: Belongs to the SARM1 family.

9555:CRYGN
gene id: 9555:CRYGN
uniprot id: A0A096MV79
uniprot id: A0A2I3N7G3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9555:MGST1
gene id: 9555:MGST1
uniprot id: A0A096NPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9555:UROD
gene id: 9555:UROD
uniprot id: A0A096NWC2
uniprot id: A0A2I3MC52
uniprot id: A0A8I5N3Z0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9555:HS3ST4
gene id: 9555:HS3ST4
uniprot id: A0A096MY37
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9555:TSSK6
gene id: 9555:TSSK6
uniprot id: A0A0A0MVT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:BABAM2
gene id: 9555:BABAM2
uniprot id: A0A096P085
uniprot id: A0A2I3LWZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9555:WASHC5
gene id: 9555:WASHC5
uniprot id: A0A096MZ78
names: Similarity
messages: Belongs to the strumpellin family.

9555:GPR12
gene id: 9555:GPR12
uniprot id: A0A096MKY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:HADHA
gene id: 9555:HADHA
uniprot id: A0A096NSI3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9555:CHRNA10
gene id: 9555:CHRNA10
uniprot id: A0A096MUW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:SLC30A3
gene id: 9555:SLC30A3
uniprot id: A0A2I3N9Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9555:RAB3C
gene id: 9555:RAB3C
uniprot id: A0A8I5NYM7
uniprot id: A0A8I5QZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9555:LONP2
gene id: 9555:LONP2
uniprot id: A0A096NI54
uniprot id: A0A2I3LZN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Peroxisome matrix

9555:UBAC2
gene id: 9555:UBAC2
uniprot id: A0A096MQI4
names: Subcellular Location Annotation
messages: Membrane

9555:USP44
gene id: 9555:USP44
uniprot id: A0A096MNN2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9555:TMEM8B
gene id: 9555:TMEM8B
uniprot id: A0A096P165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9555:SH2B2
gene id: 9555:SH2B2
uniprot id: A0A096NR70
names: Similarity
messages: Belongs to the SH2B adapter family.

9555:ATG7
gene id: 9555:ATG7
uniprot id: A0A096MXC8
uniprot id: A0A8I5MXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9555:ADAM2
gene id: 9555:ADAM2
uniprot id: A0A096NZR0
uniprot id: A0A2I3MIV8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

9555:ERF
gene id: 9555:ERF
uniprot id: A0A0A0MW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:CIAO2B
gene id: 9555:CIAO2B
uniprot id: A0A096NJA3
names: Similarity
messages: Belongs to the MIP18 family.

9555:LOC101020215
gene id: 9555:LOC101020215
uniprot id: A0A096MWU6
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CLDN7
gene id: 9555:CLDN7
uniprot id: A0A096P2N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:LOC101019361
gene id: 9555:LOC101019361
uniprot id: A0A096NGF4
names: Similarity
messages: Belongs to the COX20 family.

9555:SPIRE2
gene id: 9555:SPIRE2
uniprot id: A0A096NRF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9555:FAM131B
gene id: 9555:FAM131B
uniprot id: A0A096MSP8
uniprot id: A0A8I5N2W8
names: Similarity
messages: Belongs to the FAM131 family.

9555:LOC101010706
gene id: 9555:LOC101010706
uniprot id: A0A0A0MW35
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:GNMT
gene id: 9555:GNMT
uniprot id: A0A096NI74
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9555:GAB1
gene id: 9555:GAB1
uniprot id: A0A096N632
uniprot id: A0A2I3LFJ7
names: Similarity
messages: Belongs to the GAB family.

9555:MKS1
gene id: 9555:MKS1
uniprot id: A0A2I3N4K2
names: Subcellular Location Annotation
messages: cilium basal body

9555:CMTM8
gene id: 9555:CMTM8
uniprot id: A0A096NEK4
names: Subcellular Location Annotation
messages: Membrane

9555:VGLL3
gene id: 9555:VGLL3
uniprot id: A0A096NWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9555:RPS8
gene id: 9555:RPS8
uniprot id: A0A2I3MA04
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9555:NIPAL1
gene id: 9555:NIPAL1
uniprot id: A0A096MV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9555:NDUFAB1
gene id: 9555:NDUFAB1
uniprot id: A0A096NHF4
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9555:TPRKB
gene id: 9555:TPRKB
uniprot id: A0A2I3M7W6
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9555:CCM2
gene id: 9555:CCM2
uniprot id: A0A096MV89
uniprot id: A0A096MYG4
uniprot id: A0A2I3LHM5
uniprot id: A0A2I3LQ60
uniprot id: A0A2I3NHH5
names: Similarity
messages: Belongs to the CCM2 family.

9555:GATA1
gene id: 9555:GATA1
uniprot id: A0A096N377
names: Subcellular Location Annotation
messages: Nucleus

9555:E2F4
gene id: 9555:E2F4
uniprot id: A0A096NJB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:NAB2
gene id: 9555:NAB2
uniprot id: A0A096NQB2
uniprot id: A0A096NU99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9555:GLRX
gene id: 9555:GLRX
uniprot id: A0A096N4P5
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9555:GNPDA2
gene id: 9555:GNPDA2
uniprot id: A0A8I5NPN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9555:LOC100997529
gene id: 9555:LOC100997529
uniprot id: G4XXN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9555:HSPA9
gene id: 9555:HSPA9
uniprot id: A0A096MUK6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9555:TIMM10
gene id: 9555:TIMM10
uniprot id: A0A096MPS6
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9555:CDK4
gene id: 9555:CDK4
uniprot id: A0A096N5E4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:DAZL
gene id: 9555:DAZL
uniprot id: A0A096MPX8
names: Subcellular Location Annotation
messages: Cytoplasm

9555:LOC101022655
gene id: 9555:LOC101022655
uniprot id: A0A8I5N7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9555:SEMA6D
gene id: 9555:SEMA6D
uniprot id: A0A2I3MIW5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:MYH11
gene id: 9555:MYH11
uniprot id: A0A2I3LFK6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:SQLE
gene id: 9555:SQLE
uniprot id: A0A096N5E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9555:LOC100997829
gene id: 9555:LOC100997829
uniprot id: A0A2I3MSB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9555:PPP1R10
gene id: 9555:PPP1R10
uniprot id: A0A096NLT7
uniprot id: A0A8I5NHY1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9555:SLC7A2
gene id: 9555:SLC7A2
uniprot id: A0A096NA16
uniprot id: A0A2I3LK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9555:PPP2R2D
gene id: 9555:PPP2R2D
uniprot id: A0A096NSV1
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9555:BOD1
gene id: 9555:BOD1
uniprot id: A0A096N9V6
uniprot id: A0A8I5NJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9555:DDRGK1
gene id: 9555:DDRGK1
uniprot id: A0A096NV96
names: Similarity
messages: Belongs to the DDRGK1 family.

9555:DUSP3
gene id: 9555:DUSP3
uniprot id: A0A096P164
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9555:GJB2
gene id: 9555:GJB2
uniprot id: A0A096NEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:PPP1CA
gene id: 9555:PPP1CA
uniprot id: A0A096NBP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9555:SHMT1
gene id: 9555:SHMT1
uniprot id: A0A096P337
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9555:LETM2
gene id: 9555:LETM2
uniprot id: A0A096NYL8
names: Subcellular Location Annotation
messages: Membrane

9555:RBP4
gene id: 9555:RBP4
uniprot id: A0A096P5N4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9555:GCG
gene id: 9555:GCG
uniprot id: A0A096MTV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9555:MAP7D3
gene id: 9555:MAP7D3
uniprot id: A0A096NEF2
uniprot id: A0A2I3LTA3
names: Similarity
messages: Belongs to the MAP7 family.

9555:TMEM53
gene id: 9555:TMEM53
uniprot id: A0A2I3M1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9555:GLT6D1
gene id: 9555:GLT6D1
uniprot id: A0A096NRP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9555:CAPG
gene id: 9555:CAPG
uniprot id: A0A096NZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9555:SLCO2A1
gene id: 9555:SLCO2A1
uniprot id: A0A2I3N7F0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PSME2
gene id: 9555:PSME2
uniprot id: A0A096NX84
names: Similarity
messages: Belongs to the PA28 family.

9555:PKLR
gene id: 9555:PKLR
uniprot id: A0A2I3LL93
names: Similarity
messages: Belongs to the pyruvate kinase family.

9555:EIF2S2
gene id: 9555:EIF2S2
uniprot id: A0A8I5N9G8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9555:MUS81
gene id: 9555:MUS81
uniprot id: A0A096N654
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9555:TCAF2
gene id: 9555:TCAF2
uniprot id: A0A096N3X2
names: Similarity
messages: Belongs to the TCAF family.

9555:EHD3
gene id: 9555:EHD3
uniprot id: A0A096MQ79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9555:CNN3
gene id: 9555:CNN3
uniprot id: A0A096MP12
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9555:LOC101024203
gene id: 9555:LOC101024203
uniprot id: A0A096NCF4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

9555:MMP1
gene id: 9555:MMP1
uniprot id: A0A096MRE2
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:RGS5
gene id: 9555:RGS5
uniprot id: A0A096MLX4
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9555:DLX5
gene id: 9555:DLX5
uniprot id: A0A8I5R1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9555:LLPH
gene id: 9555:LLPH
uniprot id: A0A096MY12
names: Similarity
messages: Belongs to the learning-associated protein family.

9555:GABRR3
gene id: 9555:GABRR3
uniprot id: A0A096NU75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:ELL3
gene id: 9555:ELL3
uniprot id: A9X1C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9555:CTNNA3
gene id: 9555:CTNNA3
uniprot id: A0A096P545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: cytoskeleton

9555:PEX19
gene id: 9555:PEX19
uniprot id: A0A096MYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9555:VPS26A
gene id: 9555:VPS26A
uniprot id: A0A096P4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9555:LOC101007380
gene id: 9555:LOC101007380
uniprot id: A0A8I5QZ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:OXR1
gene id: 9555:OXR1
uniprot id: A0A096NYI7
uniprot id: A0A2I3MFX2
uniprot id: A0A2I3MHJ2
uniprot id: A0A2I3MPL4
uniprot id: A0A2I3N8P9
uniprot id: A0A2I3NHT7
names: Similarity
messages: Belongs to the OXR1 family.

9555:SERPINE2
gene id: 9555:SERPINE2
uniprot id: A0A096NYG6
names: Similarity
messages: Belongs to the serpin family.

9555:TRNT1
gene id: 9555:TRNT1
uniprot id: A0A096N3W8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9555:ERG28
gene id: 9555:ERG28
uniprot id: A0A096NS56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SLC13A3
gene id: 9555:SLC13A3
uniprot id: A0A2I3LXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9555:LGI3
gene id: 9555:LGI3
uniprot id: A0A2I3LLF9
names: Subcellular Location Annotation
messages: Secreted

9555:TAPT1
gene id: 9555:TAPT1
uniprot id: A0A096NZH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9555:PXMP2
gene id: 9555:PXMP2
uniprot id: A0A096N051
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9555:ZNF830
gene id: 9555:ZNF830
uniprot id: A0A096P3U7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9555:KRT77
gene id: 9555:KRT77
uniprot id: A0A096MN47
names: Similarity
messages: Belongs to the intermediate filament family.

9555:RXFP1
gene id: 9555:RXFP1
uniprot id: A0A096MM05
uniprot id: A0A2I3LCA8
uniprot id: A0A8I5NQD1
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ATP9B
gene id: 9555:ATP9B
uniprot id: A0A096N3I3
uniprot id: A0A096NW72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9555:SOD2
gene id: 9555:SOD2
uniprot id: A0A8I5MUU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9555:SMPX
gene id: 9555:SMPX
uniprot id: A0A096MU91
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9555:LMNB1
gene id: 9555:LMNB1
uniprot id: A0A096MS49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9555:PPP1R11
gene id: 9555:PPP1R11
uniprot id: A0A8I5N872
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9555:MAPT
gene id: 9555:MAPT
uniprot id: A0A096P681
uniprot id: A0A2I3LEF7
uniprot id: A0A2I3LT85
uniprot id: A0A2I3MFD5
uniprot id: A0A2I3NF13
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

9555:C12H11orf58
gene id: 9555:C12H11orf58
uniprot id: A0A096NRX8
names: Similarity
messages: Belongs to the SMAP family.

9555:PRDX2
gene id: 9555:PRDX2
uniprot id: A0A2I3LI37
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9555:KCTD13
gene id: 9555:KCTD13
uniprot id: A0A096NMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9555:CHAC1
gene id: 9555:CHAC1
uniprot id: A0A096NTJ9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9555:RAB3IL1
gene id: 9555:RAB3IL1
uniprot id: A0A096MQE2
uniprot id: A0A2I3MNI8
names: Similarity
messages: Belongs to the SEC2 family.

9555:KIF9
gene id: 9555:KIF9
uniprot id: A0A096NCR1
uniprot id: A0A2I3LH52
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:TUBGCP3
gene id: 9555:TUBGCP3
uniprot id: A0A096MNC6
uniprot id: A9X167
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9555:MON1A
gene id: 9555:MON1A
uniprot id: A0A096MM06
uniprot id: A0A2I3LPT3
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9555:TMEM151A
gene id: 9555:TMEM151A
uniprot id: A0A096MT00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9555:USP16
gene id: 9555:USP16
uniprot id: A0A096NAB9
uniprot id: A0A8I5RA67
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9555:CNTNAP1
gene id: 9555:CNTNAP1
uniprot id: A0A096P5U7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9555:DCLRE1C
gene id: 9555:DCLRE1C
uniprot id: E5FGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9555:AGK
gene id: 9555:AGK
uniprot id: A0A096NFB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9555:RPL18A
gene id: 9555:RPL18A
uniprot id: A0A2I3M759
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9555:GPR87
gene id: 9555:GPR87
uniprot id: A0A096MKK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:CNGA4
gene id: 9555:CNGA4
uniprot id: A0A096NYE5
names: Subcellular Location Annotation
messages: Membrane

9555:OGT
gene id: 9555:OGT
uniprot id: A0A096N3Z8
uniprot id: A0A2I3LNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9555:PRKCG
gene id: 9555:PRKCG
uniprot id: A0A0A0MVI8
uniprot id: A9L903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

9555:EFNA3
gene id: 9555:EFNA3
uniprot id: A0A2I3MY10
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ALDH6A1
gene id: 9555:ALDH6A1
uniprot id: A0A096N5G8
uniprot id: A0A8I5R9H7
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9555:CDKN1B
gene id: 9555:CDKN1B
uniprot id: A0A2I3N9L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9555:MARK2
gene id: 9555:MARK2
uniprot id: A0A2I3MTJ8
uniprot id: A0A2I3MV99
uniprot id: A0A2I3N614
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9555:GPR55
gene id: 9555:GPR55
uniprot id: A0A096NFZ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:LHFPL6
gene id: 9555:LHFPL6
uniprot id: A0A096MQ36
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101012342
gene id: 9555:LOC101012342
uniprot id: A0A8I5NQP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:BANF1
gene id: 9555:BANF1
uniprot id: A0A096MLS4
names: Subcellular Location Annotation
messages: Nucleus

9555:SIRT2
gene id: 9555:SIRT2
uniprot id: A0A0A0MVF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9555:LOC101016673
gene id: 9555:LOC101016673
uniprot id: A0A096N1A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9555:RPRD1A
gene id: 9555:RPRD1A
uniprot id: A0A2I3ME04
uniprot id: A0A2I3MTT8
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9555:KCNH1
gene id: 9555:KCNH1
uniprot id: A0A096N8P3
names: Subcellular Location Annotation
messages: Membrane

9555:KCNJ5
gene id: 9555:KCNJ5
uniprot id: A0A096N0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9555:RBP5
gene id: 9555:RBP5
uniprot id: A0A096MZT9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:SLC66A1
gene id: 9555:SLC66A1
uniprot id: A0A2I3N5X5
names: Subcellular Location Annotation
messages: Membrane

9555:FOXA1
gene id: 9555:FOXA1
uniprot id: A0A8I5N3T8
names: Subcellular Location Annotation
messages: Nucleus

9555:TCTA
gene id: 9555:TCTA
uniprot id: A0A096N2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9555:MFSD14A
gene id: 9555:MFSD14A
uniprot id: A0A096MKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9555:LAMTOR4
gene id: 9555:LAMTOR4
uniprot id: A0A096MQ77
names: Similarity
messages: Belongs to the LAMTOR4 family.

9555:B3GAT2
gene id: 9555:B3GAT2
uniprot id: A0A096MP64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:DCTPP1
gene id: 9555:DCTPP1
uniprot id: A0A096NMH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9555:SLC6A2
gene id: 9555:SLC6A2
uniprot id: A0A2I3LMR0
uniprot id: A0A2I3N0S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9555:SDR16C5
gene id: 9555:SDR16C5
uniprot id: A0A096N215
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:WNK4
gene id: 9555:WNK4
uniprot id: A0A096P5V1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9555:SNTA1
gene id: 9555:SNTA1
uniprot id: A0A096NUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9555:AMPD1
gene id: 9555:AMPD1
uniprot id: A0A096NWG9
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9555:PGLYRP2
gene id: 9555:PGLYRP2
uniprot id: A0A0A0MW87
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9555:TMEM150B
gene id: 9555:TMEM150B
uniprot id: A0A8I5N9R6
names: Subcellular Location Annotation
messages: Membrane

9555:RPL23A
gene id: 9555:RPL23A
uniprot id: A0A096MR93
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9555:LOC101022119
gene id: 9555:LOC101022119
uniprot id: A0A096N8D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9555:GPC4
gene id: 9555:GPC4
uniprot id: A0A096MRP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9555:SPIN1
gene id: 9555:SPIN1
uniprot id: A0A096P1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9555:LIN7C
gene id: 9555:LIN7C
uniprot id: A0A2I3MG07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9555:RAN
gene id: 9555:RAN
uniprot id: A0A096N379
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9555:NEUROD1
gene id: 9555:NEUROD1
uniprot id: A0A096MR04
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:CFAP298
gene id: 9555:CFAP298
uniprot id: A9CAY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9555:PYM1
gene id: 9555:PYM1
uniprot id: A0A096NFX7
uniprot id: A0A2I3MZ47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9555:PRR5L
gene id: 9555:PRR5L
uniprot id: A0A096N840
names: Similarity
messages: Belongs to the PROTOR family.

9555:CHST9
gene id: 9555:CHST9
uniprot id: A0A096N419
uniprot id: A0A2I3NDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:SIM2
gene id: 9555:SIM2
uniprot id: A0A096NJ48
names: Subcellular Location Annotation
messages: Nucleus

9555:SH2B3
gene id: 9555:SH2B3
uniprot id: A0A096N1G4
uniprot id: A0A2I3MXH4
names: Similarity
messages: Belongs to the SH2B adapter family.

9555:GFM2
gene id: 9555:GFM2
uniprot id: A0A096NY62
uniprot id: A0A8I5R7G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9555:CLDN11
gene id: 9555:CLDN11
uniprot id: A0A8I5NFZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:ANKRD34C
gene id: 9555:ANKRD34C
uniprot id: A0A096N5Y0
names: Similarity
messages: Belongs to the ANKRD34 family.

9555:MX1
gene id: 9555:MX1
uniprot id: A0A096NIX7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9555:GPR4
gene id: 9555:GPR4
uniprot id: A0A0A0MVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TMED4
gene id: 9555:TMED4
uniprot id: A0A096NEZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:LHX5
gene id: 9555:LHX5
uniprot id: A0A096N1Z4
names: Subcellular Location Annotation
messages: Nucleus

9555:SPTAN1
gene id: 9555:SPTAN1
uniprot id: A0A096P0K3
uniprot id: A0A2I3M9C3
uniprot id: A0A2I3MUN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Belongs to the spectrin family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: cell cortex
messages: cytoskeleton
messages: nuclear pore complex

9555:CREBBP
gene id: 9555:CREBBP
uniprot id: A0A096NLD5
uniprot id: A0A096NLD6
names: Subcellular Location Annotation
messages: Cytoplasm

9555:PRPF38B
gene id: 9555:PRPF38B
uniprot id: A0A096MX21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9555:BATF
gene id: 9555:BATF
uniprot id: A0A096NS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9555:CLSTN1
gene id: 9555:CLSTN1
uniprot id: A0A096MSE3
uniprot id: A0A2I3NAC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9555:ACSM5
gene id: 9555:ACSM5
uniprot id: A0A096NH80
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:KCNK15
gene id: 9555:KCNK15
uniprot id: A0A096NX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:FAM210B
gene id: 9555:FAM210B
uniprot id: A0A8I5N617
names: Similarity
messages: Belongs to the FAM210 family.

9555:RNASEH1
gene id: 9555:RNASEH1
uniprot id: A0A096NIL0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9555:CAPZA2
gene id: 9555:CAPZA2
uniprot id: A0M8R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9555:NEUROD6
gene id: 9555:NEUROD6
uniprot id: A0A2I3NC11
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9555:ANP32B
gene id: 9555:ANP32B
uniprot id: A0A096P131
names: Similarity
messages: Belongs to the ANP32 family.

9555:PROX1
gene id: 9555:PROX1
uniprot id: A0A096MPG0
uniprot id: A0A8I5NJ29
names: Subcellular Location Annotation
messages: Nucleus

9555:CHST11
gene id: 9555:CHST11
uniprot id: A0A096MU96
uniprot id: A0A8I5R1B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:SAMHD1
gene id: 9555:SAMHD1
uniprot id: H6WEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9555:SLC9A6
gene id: 9555:SLC9A6
uniprot id: A0A096MZM7
uniprot id: A0A2I3M5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9555:DPM2
gene id: 9555:DPM2
uniprot id: A0A096P1Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9555:PDE6C
gene id: 9555:PDE6C
uniprot id: A0A096P5N5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:PSMA4
gene id: 9555:PSMA4
uniprot id: A0A096NMW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9555:ENTPD1
gene id: 9555:ENTPD1
uniprot id: A0A096P5S5
uniprot id: A0A2I3MWL5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9555:MED24
gene id: 9555:MED24
uniprot id: A0A2I3LQV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9555:CACNA2D3
gene id: 9555:CACNA2D3
uniprot id: A0A096N2A4
uniprot id: A0A8I5N7M1
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9555:HCK
gene id: 9555:HCK
uniprot id: A0A096NUZ0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:ITIH3
gene id: 9555:ITIH3
uniprot id: A0A096NDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9555:AKR1D1
gene id: 9555:AKR1D1
uniprot id: A0A096N3M1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9555:PADI3
gene id: 9555:PADI3
uniprot id: A0A096NDW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9555:TMEM54
gene id: 9555:TMEM54
uniprot id: A0A096MVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9555:BLOC1S5
gene id: 9555:BLOC1S5
uniprot id: A0A096NKU4
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9555:TLR9
gene id: 9555:TLR9
uniprot id: A0A096N6Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Lysosome
messages: Membrane
messages: phagosome

9555:TMTC2
gene id: 9555:TMTC2
uniprot id: A0A2I3LS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9555:TIMM17A
gene id: 9555:TIMM17A
uniprot id: A0A096MMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9555:SNX10
gene id: 9555:SNX10
uniprot id: A0A096NGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9555:TXLNA
gene id: 9555:TXLNA
uniprot id: A0A096N233
names: Similarity
messages: Belongs to the taxilin family.

9555:SLC19A2
gene id: 9555:SLC19A2
uniprot id: A0A096N995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9555:DSC1
gene id: 9555:DSC1
uniprot id: A0A2I3M535
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9555:SERPINB4
gene id: 9555:SERPINB4
uniprot id: A9RA91
names: Similarity
messages: Belongs to the serpin family.

9555:VNN1
gene id: 9555:VNN1
uniprot id: A0A096N5B0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9555:ECH1
gene id: 9555:ECH1
uniprot id: A0A0A0MU52
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9555:TMEM121B
gene id: 9555:TMEM121B
uniprot id: A0A096NVX4
names: Similarity
messages: Belongs to the TMEM121 family.

9555:REEP1
gene id: 9555:REEP1
uniprot id: A0A2I3MJV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9555:DEFB1
gene id: 9555:DEFB1
uniprot id: P61262
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9555:MCOLN2
gene id: 9555:MCOLN2
uniprot id: A0A096MXN5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9555:NR0B2
gene id: 9555:NR0B2
uniprot id: A0A096N961
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9555:MYO16
gene id: 9555:MYO16
uniprot id: A0A2I3M1P7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:SS18L2
gene id: 9555:SS18L2
uniprot id: A0A096MU15
names: Similarity
messages: Belongs to the SS18 family.

9555:LOC101006909
gene id: 9555:LOC101006909
uniprot id: A0A2I3MG70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9555:LOC101020627
gene id: 9555:LOC101020627
uniprot id: A0A096NCF6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:MON2
gene id: 9555:MON2
uniprot id: A0A096MRP8
names: Similarity
messages: Belongs to the MON2 family.

9555:VIM
gene id: 9555:VIM
uniprot id: A0A2I3MND3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9555:SPACA4
gene id: 9555:SPACA4
uniprot id: A0A8I5P293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9555:DSG2
gene id: 9555:DSG2
uniprot id: A0A096NXU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9555:MEGF8
gene id: 9555:MEGF8
uniprot id: A0A0A0MX68
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TNPO1
gene id: 9555:TNPO1
uniprot id: A0A096MVQ5
uniprot id: A0A2I3N966
names: Subcellular Location Annotation
messages: Cytoplasm

9555:NFKB1
gene id: 9555:NFKB1
uniprot id: A0A096NDA9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:PPARA
gene id: 9555:PPARA
uniprot id: A0A096NKS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9555:UBE2A
gene id: 9555:UBE2A
uniprot id: A0A096MKL8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:FABP12
gene id: 9555:FABP12
uniprot id: A0A096N6X7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:LOC101009919
gene id: 9555:LOC101009919
uniprot id: A0A096MWB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:TCTE3
gene id: 9555:TCTE3
uniprot id: A0A096NWF7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9555:AP3M1
gene id: 9555:AP3M1
uniprot id: A0A096P4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9555:TRAF3
gene id: 9555:TRAF3
uniprot id: A0A096NJV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9555:RIPOR3
gene id: 9555:RIPOR3
uniprot id: A0A096NNP7
names: Similarity
messages: Belongs to the RIPOR family.

9555:FIGN
gene id: 9555:FIGN
uniprot id: A0A2I3LNL5
names: Similarity
messages: Belongs to the AAA ATPase family.

9555:CDK2AP1
gene id: 9555:CDK2AP1
uniprot id: A0A096NXI5
names: Similarity
messages: Belongs to the CDK2AP family.

9555:FSHB
gene id: 9555:FSHB
uniprot id: A0A8I5R6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9555:PIK3R2
gene id: 9555:PIK3R2
uniprot id: A0A0A0MVM4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9555:TAZ
gene id: 9555:TAZ
uniprot id: A9CB62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9555:GPR83
gene id: 9555:GPR83
uniprot id: A0A8I5N331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:VAX1
gene id: 9555:VAX1
uniprot id: A0A096NTV3
uniprot id: A0A2I3MYP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9555:LOC101018613
gene id: 9555:LOC101018613
uniprot id: A0A8I5MYE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9555:TBC1D24
gene id: 9555:TBC1D24
uniprot id: A0A096NL62
uniprot id: A0A2I3M1U7
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

9555:CTNNB1
gene id: 9555:CTNNB1
uniprot id: A0A096MY68
uniprot id: A0A8I5R5V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9555:LOC101025731
gene id: 9555:LOC101025731
uniprot id: A0A096NLU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9555:PPIP5K1
gene id: 9555:PPIP5K1
uniprot id: A9X1B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9555:CLPP
gene id: 9555:CLPP
uniprot id: A0A8I5N433
names: Similarity
messages: Belongs to the peptidase S14 family.

9555:TPPP3
gene id: 9555:TPPP3
uniprot id: A0A096NE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9555:MEIG1
gene id: 9555:MEIG1
uniprot id: A0A096P3J1
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9555:LYRM9
gene id: 9555:LYRM9
uniprot id: A0A8I5N8V5
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9555:PIK3CG
gene id: 9555:PIK3CG
uniprot id: A0A096NGU7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9555:CREB5
gene id: 9555:CREB5
uniprot id: A0A2I3LF32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9555:CD40LG
gene id: 9555:CD40LG
uniprot id: A0A8I5NJQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9555:IL4I1
gene id: 9555:IL4I1
uniprot id: A0A0A0MW10
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9555:PDE5A
gene id: 9555:PDE5A
uniprot id: A0A096NA83
uniprot id: A0A096NYB4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:TMEM170B
gene id: 9555:TMEM170B
uniprot id: A0A2I3NHQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9555:NUP50
gene id: 9555:NUP50
uniprot id: A0A2I3M7T7
names: Subcellular Location Annotation
messages: nuclear pore complex

9555:GMPPA
gene id: 9555:GMPPA
uniprot id: B0CM52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GMPPB.
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site.
messages: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.

9555:IL1B
gene id: 9555:IL1B
uniprot id: A0A2I3N9K4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9555:PRDM1
gene id: 9555:PRDM1
uniprot id: A0A2I3LS01
uniprot id: A0A8I5NJS0
uniprot id: A0A8I5QZ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9555:CHRNB4
gene id: 9555:CHRNB4
uniprot id: A0A096NMW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:METAP1
gene id: 9555:METAP1
uniprot id: A0A096MVW1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9555:LOC101019367
gene id: 9555:LOC101019367
uniprot id: A0A8I5NKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SENP8
gene id: 9555:SENP8
uniprot id: A0A096MNS5
names: Similarity
messages: Belongs to the peptidase C48 family.

9555:HYI
gene id: 9555:HYI
uniprot id: A0A096N0K9
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9555:AK4
gene id: 9555:AK4
uniprot id: A0A096NDR4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9555:AMIGO3
gene id: 9555:AMIGO3
uniprot id: A0A096N7J4
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9555:PKP2
gene id: 9555:PKP2
uniprot id: A0A2I3LM88
names: Similarity
messages: Belongs to the beta-catenin family.

9555:DLX4
gene id: 9555:DLX4
uniprot id: A0A096P462
names: Subcellular Location Annotation
messages: Nucleus

9555:NAA10
gene id: 9555:NAA10
uniprot id: A9CB50
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9555:SNAPC4
gene id: 9555:SNAPC4
uniprot id: A0A096NRS9
names: Subcellular Location Annotation
messages: Nucleus

9555:SLCO1B3
gene id: 9555:SLCO1B3
uniprot id: A0A096MNA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PRKN
gene id: 9555:PRKN
uniprot id: A0A096MX93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9555:RXFP4
gene id: 9555:RXFP4
uniprot id: A0A096NDZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:MRPL27
gene id: 9555:MRPL27
uniprot id: A0A2I3N0C6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9555:TLR5
gene id: 9555:TLR5
uniprot id: B9VGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9555:EEF1B2
gene id: 9555:EEF1B2
uniprot id: A0A096MTA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9555:TRIM59
gene id: 9555:TRIM59
uniprot id: A0A096N730
names: Subcellular Location Annotation
messages: Nucleus

9555:APMAP
gene id: 9555:APMAP
uniprot id: A0A8I5NIL8
names: Similarity
messages: Belongs to the strictosidine synthase family.

9555:SPESP1
gene id: 9555:SPESP1
uniprot id: A0A096NMH6
names: Function
names: Similarity
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.

9555:SNX8
gene id: 9555:SNX8
uniprot id: A0A096NQJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9555:AR
gene id: 9555:AR
uniprot id: A0A096N199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9555:PARP9
gene id: 9555:PARP9
uniprot id: A0A096NYJ3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:LCLAT1
gene id: 9555:LCLAT1
uniprot id: A0A096N154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:DLL1
gene id: 9555:DLL1
uniprot id: A0A096MZ51
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9555:BAP1
gene id: 9555:BAP1
uniprot id: A0A096N2N6
names: Similarity
messages: Belongs to the peptidase C12 family.

9555:LOC101024012
gene id: 9555:LOC101024012
uniprot id: A0A096MZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9555:LOC101000761
gene id: 9555:LOC101000761
uniprot id: A0A096MV55
uniprot id: A0A096N0N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9555:PSKH1
gene id: 9555:PSKH1
uniprot id: A0A096N2R9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:GRPEL1
gene id: 9555:GRPEL1
uniprot id: A0A8I5R942
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9555:ZBED4
gene id: 9555:ZBED4
uniprot id: A0A096MLJ0
names: Subcellular Location Annotation
messages: Nucleus

9555:ZNF711
gene id: 9555:ZNF711
uniprot id: A0A2I3MH68
uniprot id: A0A2I3MKH3
names: Subcellular Location Annotation
messages: Nucleus

9555:TRIM25
gene id: 9555:TRIM25
uniprot id: A0A096P4Q9
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9555:TMEM170A
gene id: 9555:TMEM170A
uniprot id: A0A2I3N2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9555:LOC101012229
gene id: 9555:LOC101012229
uniprot id: A0A096NLJ7
names: Subcellular Location Annotation
messages: Nucleus

9555:STARD6
gene id: 9555:STARD6
uniprot id: A0A2I3MJY8
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9555:EID2
gene id: 9555:EID2
uniprot id: A0A0A0MWE4
names: Subcellular Location Annotation
messages: Nucleus

9555:KRT20
gene id: 9555:KRT20
uniprot id: A0A096P5J1
names: Similarity
messages: Belongs to the intermediate filament family.

9555:ZKSCAN5
gene id: 9555:ZKSCAN5
uniprot id: A0A096MWU2
names: Subcellular Location Annotation
messages: Nucleus

9555:CFAP126
gene id: 9555:CFAP126
uniprot id: A0A096MP43
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9555:OIP5
gene id: 9555:OIP5
uniprot id: A0A096NTL9
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9555:CD70
gene id: 9555:CD70
uniprot id: A0A0A0MVV2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:SERPINB1
gene id: 9555:SERPINB1
uniprot id: A0A2I3MTL8
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9555:PMVK
gene id: 9555:PMVK
uniprot id: A0A8I5NET5
names: Subcellular Location Annotation
messages: cytosol

9555:C9H12orf10
gene id: 9555:C9H12orf10
uniprot id: A0A096ML92
names: Similarity
messages: Belongs to the MYG1 family.

9555:CPT1B
gene id: 9555:CPT1B
uniprot id: A0A2I3LW20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:VAC14
gene id: 9555:VAC14
uniprot id: A0A2I3MIB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9555:OLFM2
gene id: 9555:OLFM2
uniprot id: A0A2I3NA02
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9555:CLRN1
gene id: 9555:CLRN1
uniprot id: A0A096N8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9555:CFAP300
gene id: 9555:CFAP300
uniprot id: A0A2I3NE63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9555:HIST1H3A
gene id: 9555:HIST1H3A
uniprot id: A9RA98
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LIN7A
gene id: 9555:LIN7A
uniprot id: A0A096N3P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9555:MSMP
gene id: 9555:MSMP
uniprot id: A0A096P171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9555:KCNK9
gene id: 9555:KCNK9
uniprot id: A0A096MTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9555:LOC101015487
gene id: 9555:LOC101015487
uniprot id: A0A2I3MAK1
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9555:TM9SF2
gene id: 9555:TM9SF2
uniprot id: A0A2I3NDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9555:PROP1
gene id: 9555:PROP1
uniprot id: A0A2I3M5D5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

9555:RPL24
gene id: 9555:RPL24
uniprot id: A0A096MYF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9555:KCNH7
gene id: 9555:KCNH7
uniprot id: A0A2I3MBJ1
names: Subcellular Location Annotation
messages: Membrane

9555:ADPRS
gene id: 9555:ADPRS
uniprot id: A0A096N3D8
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9555:RTN2
gene id: 9555:RTN2
uniprot id: A0A0A0MXE7
uniprot id: A0A2I3NFM5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:GPN3
gene id: 9555:GPN3
uniprot id: A0A2I3MY60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9555:ANXA7
gene id: 9555:ANXA7
uniprot id: A0A096P4N6
uniprot id: A0A2I3LQW3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9555:ATPAF1
gene id: 9555:ATPAF1
uniprot id: A0A096NYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

9555:SLC7A10
gene id: 9555:SLC7A10
uniprot id: A0A0A0MUG8
names: Subcellular Location Annotation
messages: Membrane

9555:TGIF2
gene id: 9555:TGIF2
uniprot id: A0A096NUK5
names: Subcellular Location Annotation
messages: Nucleus

9555:PSME1
gene id: 9555:PSME1
uniprot id: A0A2I3LW29
names: Similarity
messages: Belongs to the PA28 family.

9555:PDCD4
gene id: 9555:PDCD4
uniprot id: A0A2I3MDN3
names: Similarity
messages: Belongs to the PDCD4 family.

9555:TNFRSF10B
gene id: 9555:TNFRSF10B
uniprot id: A0A096N2N7
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9555:LOC101012460
gene id: 9555:LOC101012460
uniprot id: A0A096NQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9555:GRIA2
gene id: 9555:GRIA2
uniprot id: A0A096MWL5
uniprot id: A0A2I3LN27
uniprot id: A0A8I5N698
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:DES
gene id: 9555:DES
uniprot id: B0CM49
names: Similarity
messages: Belongs to the intermediate filament family.

9555:CTSE
gene id: 9555:CTSE
uniprot id: A0A096N3G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
messages: Secreted

9555:SNU13
gene id: 9555:SNU13
uniprot id: A0A8I5R811
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9555:TIPIN
gene id: 9555:TIPIN
uniprot id: A0A096NME8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9555:LPAR3
gene id: 9555:LPAR3
uniprot id: A0A096N292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:LOC101020929
gene id: 9555:LOC101020929
uniprot id: A0A2I3M0D7
names: Similarity
messages: Belongs to the GAGE family.

9555:VRK1
gene id: 9555:VRK1
uniprot id: A0A096NJP0
uniprot id: A0A8I5NNJ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:TRMT6
gene id: 9555:TRMT6
uniprot id: A0A096NVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9555:KCNH6
gene id: 9555:KCNH6
uniprot id: A0A096P6D6
uniprot id: A0A2I3MK53
names: Subcellular Location Annotation
messages: Membrane

9555:FAM189B
gene id: 9555:FAM189B
uniprot id: A0A096N0T8
uniprot id: A0A2I3NEQ6
names: Similarity
messages: Belongs to the ENTREP family.

9555:ELF4
gene id: 9555:ELF4
uniprot id: A0A2I3MEQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:SDHAF4
gene id: 9555:SDHAF4
uniprot id: A0A096NW41
names: Similarity
messages: Belongs to the SDHAF4 family.

9555:APOA1
gene id: 9555:APOA1
uniprot id: A0A0B4J2H6
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9555:DPH5
gene id: 9555:DPH5
uniprot id: A0A096MX22
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9555:ARFGEF1
gene id: 9555:ARFGEF1
uniprot id: A0A096MQ19
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9555:CRELD1
gene id: 9555:CRELD1
uniprot id: A0A096N9D9
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NMNAT3
gene id: 9555:NMNAT3
uniprot id: A0A096N0Z8
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9555:SUCLA2
gene id: 9555:SUCLA2
uniprot id: A0A096NFT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9555:CNTFR
gene id: 9555:CNTFR
uniprot id: A0A096P1B0
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9555:PEAR1
gene id: 9555:PEAR1
uniprot id: A0A096N1B4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:COPS7B
gene id: 9555:COPS7B
uniprot id: A0A096NA46
uniprot id: A0A2I3LIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9555:EXOSC1
gene id: 9555:EXOSC1
uniprot id: A0A096P606
names: Subcellular Location Annotation
messages: Cytoplasm

9555:ARL8B
gene id: 9555:ARL8B
uniprot id: A0A096NU74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9555:RDM1
gene id: 9555:RDM1
uniprot id: A0A096P3Y5
uniprot id: A0A2I3MFI3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9555:SEC11A
gene id: 9555:SEC11A
uniprot id: A0A096NN18
uniprot id: A0A2I3LM76
uniprot id: A0A2I3MEZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:LOC101024707
gene id: 9555:LOC101024707
uniprot id: A0A096P3B2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9555:MMP7
gene id: 9555:MMP7
uniprot id: A0A096N6P6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9555:UTP3
gene id: 9555:UTP3
uniprot id: A0A096MRT8
names: Similarity
messages: Belongs to the SAS10 family.

9555:CLIC2
gene id: 9555:CLIC2
uniprot id: A0A096MLZ7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9555:GATM
gene id: 9555:GATM
uniprot id: A0A096NLZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9555:TP53INP1
gene id: 9555:TP53INP1
uniprot id: A0A096NAV6
uniprot id: A0A2I3MK96
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9555:KIF27
gene id: 9555:KIF27
uniprot id: A0A096P1V9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:DENND6B
gene id: 9555:DENND6B
uniprot id: A0A2I3M7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9555:LOC101017387
gene id: 9555:LOC101017387
uniprot id: A0A096NAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9555:ATRAID
gene id: 9555:ATRAID
uniprot id: A0A096NAA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:MFSD6L
gene id: 9555:MFSD6L
uniprot id: A0A8I5NAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9555:ELOVL1
gene id: 9555:ELOVL1
uniprot id: A0A096N934
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9555:SLC25A33
gene id: 9555:SLC25A33
uniprot id: A0A096N789
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:SORL1
gene id: 9555:SORL1
uniprot id: A0A096N4B3
uniprot id: A0A8I5NV82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9555:STS
gene id: 9555:STS
uniprot id: A0A096NP88
uniprot id: A0A2I3LME9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:TNFAIP6
gene id: 9555:TNFAIP6
uniprot id: A0A096MTD2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:AZIN1
gene id: 9555:AZIN1
uniprot id: A0A096N329
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9555:HMGN4
gene id: 9555:HMGN4
uniprot id: A0A2I3LZS1
uniprot id: A0A8I5NPQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9555:PEX2
gene id: 9555:PEX2
uniprot id: A0A096N112
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9555:OTUB2
gene id: 9555:OTUB2
uniprot id: A0A2I3MTU3
names: Similarity
messages: Belongs to the peptidase C65 family.

9555:LOC101016467
gene id: 9555:LOC101016467
uniprot id: A0A096NWG4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9555:GSG1
gene id: 9555:GSG1
uniprot id: A0A2I3MP76
uniprot id: A0A2I3N4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9555:CXCL11
gene id: 9555:CXCL11
uniprot id: A0A096MV97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:LOC101011665
gene id: 9555:LOC101011665
uniprot id: A0A2I3MNN3
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9555:MRPS14
gene id: 9555:MRPS14
uniprot id: A0A096MUM0
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9555:SLC5A6
gene id: 9555:SLC5A6
uniprot id: A0A096P0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:KCNAB2
gene id: 9555:KCNAB2
uniprot id: A0A096MLE4
uniprot id: A0A8I5N2W4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: axon
messages: cytoskeleton
messages: synaptosome

9555:TMEM255A
gene id: 9555:TMEM255A
uniprot id: A0A096MXR5
uniprot id: A0A2I3N1P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9555:BGLAP
gene id: 9555:BGLAP
uniprot id: A0A096N2Y6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9555:MAU2
gene id: 9555:MAU2
uniprot id: A0A0A0MV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9555:B2M
gene id: 9555:B2M
uniprot id: Q6T672
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9555:CREB3L2
gene id: 9555:CREB3L2
uniprot id: A0A096NR00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9555:SCIN
gene id: 9555:SCIN
uniprot id: A0A096NQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9555:TUBG1
gene id: 9555:TUBG1
uniprot id: A0A096P5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9555:ZNF326
gene id: 9555:ZNF326
uniprot id: A0A096MKT6
names: Similarity
messages: Belongs to the AKAP95 family.

9555:ALDH1A1
gene id: 9555:ALDH1A1
uniprot id: A0A096P1S3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:TAF12
gene id: 9555:TAF12
uniprot id: A0A096N6R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9555:SERPINB8
gene id: 9555:SERPINB8
uniprot id: A0A2I3LCT0
uniprot id: A9RA97
names: Similarity
messages: Belongs to the serpin family.

9555:TNNT3
gene id: 9555:TNNT3
uniprot id: A0A096NPU7
uniprot id: A0A2I3LGY5
uniprot id: A9L953
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9555:LYRM4
gene id: 9555:LYRM4
uniprot id: A0A2I3MAL7
names: Similarity
messages: Belongs to the complex I LYR family.

9555:COQ10A
gene id: 9555:COQ10A
uniprot id: A0A096NH03
uniprot id: A0A2I3MF28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9555:CD44
gene id: 9555:CD44
uniprot id: A0A096NAI8
uniprot id: A0A2I3LCP2
uniprot id: A0A2I3LSR3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9555:EPS8L3
gene id: 9555:EPS8L3
uniprot id: A0A096MMJ2
names: Similarity
messages: Belongs to the EPS8 family.

9555:GHRHR
gene id: 9555:GHRHR
uniprot id: A0A2I3LMD1
uniprot id: A0A2I3M207
names: Subcellular Location Annotation
messages: Membrane

9555:SLC25A14
gene id: 9555:SLC25A14
uniprot id: A0A096N4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:CD180
gene id: 9555:CD180
uniprot id: A0A096MW66
names: Similarity
messages: Belongs to the Toll-like receptor family.

9555:EDNRA
gene id: 9555:EDNRA
uniprot id: A0A8I5N0F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9555:CENPN
gene id: 9555:CENPN
uniprot id: A0A096NUI4
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9555:THYN1
gene id: 9555:THYN1
uniprot id: A0A096N7J7
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9555:TRAF1
gene id: 9555:TRAF1
uniprot id: A0A096P0Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9555:UGT1A5B
gene id: 9555:UGT1A5B
uniprot id: Q20CL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:CMC2
gene id: 9555:CMC2
uniprot id: A0A8I5NYA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9555:NOP10
gene id: 9555:NOP10
uniprot id: A0A8I5NJL7
names: Similarity
messages: Belongs to the NOP10 family.

9555:ACSM2B
gene id: 9555:ACSM2B
uniprot id: A0A096NH82
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:SPTSSB
gene id: 9555:SPTSSB
uniprot id: A0A096NBI7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:PUF60
gene id: 9555:PUF60
uniprot id: A0A2I3M7U8
uniprot id: A0A2I3MX19
uniprot id: A0A2I3MY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9555:NOX1
gene id: 9555:NOX1
uniprot id: A0A096MKS0
uniprot id: A0A2I3LP20
names: Subcellular Location Annotation
messages: Membrane

9555:TYRO3
gene id: 9555:TYRO3
uniprot id: A0A2I3MGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9555:TNNT2
gene id: 9555:TNNT2
uniprot id: A0A096MLA8
uniprot id: A0A096MMI7
uniprot id: A0A2I3LLE4
uniprot id: A0A2I3LXC3
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9555:TRAM2
gene id: 9555:TRAM2
uniprot id: A0A096NJ51
uniprot id: A0A2I3LFA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9555:CNP
gene id: 9555:CNP
uniprot id: A0A096P5R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9555:ICAM3
gene id: 9555:ICAM3
uniprot id: A0A0A0MV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9555:GDF6
gene id: 9555:GDF6
uniprot id: A0A096MW46
names: Similarity
messages: Belongs to the TGF-beta family.

9555:ASF1A
gene id: 9555:ASF1A
uniprot id: A0A096MSH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9555:ANAPC1
gene id: 9555:ANAPC1
uniprot id: A0A096N2J1
names: Similarity
messages: Belongs to the APC1 family.

9555:TMEM134
gene id: 9555:TMEM134
uniprot id: A0A096MM70
uniprot id: A0A2I3N6Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9555:EVL
gene id: 9555:EVL
uniprot id: A0A096NJR0
uniprot id: A0A2I3MIZ9
uniprot id: A0A2I3MRY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9555:PAQR8
gene id: 9555:PAQR8
uniprot id: A0A096N8P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9555:DOC2B
gene id: 9555:DOC2B
uniprot id: A0A2I3LYS7
names: Subcellular Location Annotation
messages: Membrane

9555:SF3B4
gene id: 9555:SF3B4
uniprot id: A0A096MR38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9555:APLP2
gene id: 9555:APLP2
uniprot id: A0A096MNK9
uniprot id: A0A096MXA8
uniprot id: A0A2I3LNR5
uniprot id: A0A2I3NBU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PPP1R16A
gene id: 9555:PPP1R16A
uniprot id: A0A096N2Z2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:NOS1
gene id: 9555:NOS1
uniprot id: A0A096N287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: dendritic spine
messages: sarcolemma

9555:HDHD3
gene id: 9555:HDHD3
uniprot id: A0A096N8Q4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9555:TSPAN11
gene id: 9555:TSPAN11
uniprot id: A0A096N9J4
uniprot id: A0A8I5NBH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:EFNA5
gene id: 9555:EFNA5
uniprot id: A0A096MU88
uniprot id: A0A2I3MB61
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:AADACL2
gene id: 9555:AADACL2
uniprot id: A0A096N9N3
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9555:SLC12A9
gene id: 9555:SLC12A9
uniprot id: A0A096MWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9555:LYRM2
gene id: 9555:LYRM2
uniprot id: A0A096MWU3
names: Similarity
messages: Belongs to the complex I LYR family.

9555:INTS10
gene id: 9555:INTS10
uniprot id: A0A096MXL7
uniprot id: A0A2I3MF91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9555:EMC6
gene id: 9555:EMC6
uniprot id: A0A096NRU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:ADD1
gene id: 9555:ADD1
uniprot id: A0A096NGL5
uniprot id: A0A096NZ36
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9555:PRDM10
gene id: 9555:PRDM10
uniprot id: A0A096N8F2
uniprot id: A0A2I3ML56
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:SLC35D2
gene id: 9555:SLC35D2
uniprot id: A0A8I5MXV7
names: Subcellular Location Annotation
messages: Membrane

9555:NF2
gene id: 9555:NF2
uniprot id: A0A2I3MFF5
uniprot id: P59750
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell projection
messages: Interacts with SLC9A3R1, HGS and AGAP2. Interacts with SGSM3. Interacts (via FERM domain) with MPP1 (By similarity). Interacts with LAYN and WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1. Interacts (via FERM domain) with NOP53; the interaction is direct. Interacts with SCHIP1; the interaction is direct.
messages: Membrane
messages: Nucleus
messages: Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail.
messages: Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. The dephosphorylation of Ser-518 favors the interaction with NOP53.
messages: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity).
messages: Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation.
messages: cytoskeleton

9555:LOC101005160
gene id: 9555:LOC101005160
uniprot id: A0A2I3N5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9555:RTN1
gene id: 9555:RTN1
uniprot id: A0A096NVF6
uniprot id: A0A2I3MM18
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:TEX28
gene id: 9555:TEX28
uniprot id: A9CB55
names: Similarity
messages: Belongs to the TEX28 family.

9555:LRRC8D
gene id: 9555:LRRC8D
uniprot id: A0A8I5N480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9555:PNOC
gene id: 9555:PNOC
uniprot id: A0A096MXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9555:B4GALNT1
gene id: 9555:B4GALNT1
uniprot id: A0A096NBX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:TMEM265
gene id: 9555:TMEM265
uniprot id: A0A2I3MPH4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9555:ZACN
gene id: 9555:ZACN
uniprot id: A0A096NT19
names: Subcellular Location Annotation
messages: Membrane

9555:ASB5
gene id: 9555:ASB5
uniprot id: A0A096NQL3
uniprot id: A0A2I3LYV4
uniprot id: A0A8I5NDP9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:CTTNBP2
gene id: 9555:CTTNBP2
uniprot id: A0M8S4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9555:EIF1AD
gene id: 9555:EIF1AD
uniprot id: A0A096N550
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9555:FZD1
gene id: 9555:FZD1
uniprot id: B0CM30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:CACNG3
gene id: 9555:CACNG3
uniprot id: A0A2I3M816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9555:ZC3H12C
gene id: 9555:ZC3H12C
uniprot id: A0A096N6I0
uniprot id: A0A2I3NAU4
names: Similarity
messages: Belongs to the ZC3H12 family.

9555:LOC101008578
gene id: 9555:LOC101008578
uniprot id: A0A096ND95
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9555:CCDC167
gene id: 9555:CCDC167
uniprot id: A0A096NHV3
names: Subcellular Location Annotation
messages: Membrane

9555:OLFR575
gene id: 9555:OLFR575
uniprot id: A9L8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:EIF1B
gene id: 9555:EIF1B
uniprot id: A0A2I3MK00
names: Similarity
messages: Belongs to the SUI1 family.

9555:SLC28A2
gene id: 9555:SLC28A2
uniprot id: A0A096NLZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9555:NCAPG
gene id: 9555:NCAPG
uniprot id: A0A096NZI5
uniprot id: A0A8I5NMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9555:PPP3CC
gene id: 9555:PPP3CC
uniprot id: A0A096N243
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9555:ATP11A
gene id: 9555:ATP11A
uniprot id: A9X168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9555:MIEF2
gene id: 9555:MIEF2
uniprot id: A0A8I5NLX8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9555:MARCKSL1
gene id: 9555:MARCKSL1
uniprot id: A0A096NFT8
names: Similarity
messages: Belongs to the MARCKS family.

9555:SCRN2
gene id: 9555:SCRN2
uniprot id: A0A096P404
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9555:PHF19
gene id: 9555:PHF19
uniprot id: A0A096P0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9555:SRSF2
gene id: 9555:SRSF2
uniprot id: A0A096NT49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

9555:MIF
gene id: 9555:MIF
uniprot id: A0A2I3M5Q0
names: Similarity
messages: Belongs to the MIF family.

9555:ACP1
gene id: 9555:ACP1
uniprot id: A0A2I3MSC9
uniprot id: A0A8I5R2N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9555:NPR3
gene id: 9555:NPR3
uniprot id: A0A096N6E9
uniprot id: A0A8I5MW08
names: Subcellular Location Annotation
messages: Membrane

9555:MLF1
gene id: 9555:MLF1
uniprot id: A0A096NYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9555:PLPPR4
gene id: 9555:PLPPR4
uniprot id: A0A8I5NMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9555:NR3C2
gene id: 9555:NR3C2
uniprot id: A0A096MV60
names: Subcellular Location Annotation
messages: Nucleus

9555:PTH2R
gene id: 9555:PTH2R
uniprot id: A0A096MXH3
names: Subcellular Location Annotation
messages: Membrane

9555:IL4R
gene id: 9555:IL4R
uniprot id: A0A096NHJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9555:AIPL1
gene id: 9555:AIPL1
uniprot id: A0A096P2K6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

9555:SPIC
gene id: 9555:SPIC
uniprot id: A0A2I3NDG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:OAS1
gene id: 9555:OAS1
uniprot id: A0A096N990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9555:SERINC3
gene id: 9555:SERINC3
uniprot id: A0A096NX96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9555:SRP54
gene id: 9555:SRP54
uniprot id: A0A2I3NHN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

9555:MARK4
gene id: 9555:MARK4
uniprot id: A0A2I3LQ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9555:BTC
gene id: 9555:BTC
uniprot id: A0A096MX40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SUMF2
gene id: 9555:SUMF2
uniprot id: A0A096NW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9555:ARHGAP26
gene id: 9555:ARHGAP26
uniprot id: A0A096P012
uniprot id: A0A2I3LJL6
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9555:S100A10
gene id: 9555:S100A10
uniprot id: A0A2I3LUR9
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9555:RAB33B
gene id: 9555:RAB33B
uniprot id: A0A096N0N8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9555:LOC100998247
gene id: 9555:LOC100998247
uniprot id: A0A096P5L4
names: Similarity
messages: Belongs to the intermediate filament family.

9555:CADM3
gene id: 9555:CADM3
uniprot id: A0A096NQF2
uniprot id: A0A2I3MK19
names: Similarity
messages: Belongs to the nectin family.

9555:DICER1
gene id: 9555:DICER1
uniprot id: A0A096NJK7
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9555:CASC1
gene id: 9555:CASC1
uniprot id: A0A096MY43
uniprot id: A0A2I3NBT3
names: Similarity
messages: Belongs to the DNAI7 family.

9555:LRTOMT
gene id: 9555:LRTOMT
uniprot id: A0A2I3MDB0
uniprot id: B6CZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Endoplasmic reticulum

9555:RIOK1
gene id: 9555:RIOK1
uniprot id: A0A096NKS3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9555:IMPDH2
gene id: 9555:IMPDH2
uniprot id: A0A096NQP5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9555:CELF2
gene id: 9555:CELF2
uniprot id: A0A2I3LX85
uniprot id: A0A2I3MN26
uniprot id: A0A2I3NI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9555:TIMP1
gene id: 9555:TIMP1
uniprot id: A0A096MLD2
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9555:LDB1
gene id: 9555:LDB1
uniprot id: A0A096P6D1
uniprot id: A0A2I3LYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9555:SLC25A25
gene id: 9555:SLC25A25
uniprot id: A0A096P1Y7
uniprot id: A0A2I3LFT5
uniprot id: A0A2I3LHU5
uniprot id: A0A2I3N1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9555:CCNL1
gene id: 9555:CCNL1
uniprot id: A0A2I3NH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9555:NFIL3
gene id: 9555:NFIL3
uniprot id: A0A096N905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9555:CLNS1A
gene id: 9555:CLNS1A
uniprot id: A0A096N4Y3
uniprot id: A0A2I3MM74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9555:PARP12
gene id: 9555:PARP12
uniprot id: A0A096NG88
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:HIBADH
gene id: 9555:HIBADH
uniprot id: A0A096N6A2
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9555:ACVR2A
gene id: 9555:ACVR2A
uniprot id: A0A096NSM4
uniprot id: A0A096NSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9555:COR52P3
gene id: 9555:COR52P3
uniprot id: A9L8Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:CTF1
gene id: 9555:CTF1
uniprot id: A0A096NHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9555:RASGRP1
gene id: 9555:RASGRP1
uniprot id: A0A096NTD5
names: Similarity
messages: Belongs to the RASGRP family.

9555:LOC101024135
gene id: 9555:LOC101024135
uniprot id: A0A096MW83
names: Similarity
messages: Belongs to the intermediate filament family.

9555:CLDN4
gene id: 9555:CLDN4
uniprot id: A0A096MKU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:ATP5PF
gene id: 9555:ATP5PF
uniprot id: A0A8I5R105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9555:VOPP1
gene id: 9555:VOPP1
uniprot id: A0A2I3NDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane

9555:SYNJ1
gene id: 9555:SYNJ1
uniprot id: A0A096N272
uniprot id: A0A096NBU6
uniprot id: A0A2I3LVH5
uniprot id: A9CAZ0
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9555:PLA1A
gene id: 9555:PLA1A
uniprot id: A0A096NSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9555:MOCS2
gene id: 9555:MOCS2
uniprot id: A0A096MYN8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9555:CIAO2A
gene id: 9555:CIAO2A
uniprot id: A0A096NMB2
names: Similarity
messages: Belongs to the MIP18 family.

9555:GSDME
gene id: 9555:GSDME
uniprot id: A0A096MVJ4
uniprot id: A0A8I5N7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9555:TSC22D4
gene id: 9555:TSC22D4
uniprot id: A0A096NWL2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9555:ZCCHC4
gene id: 9555:ZCCHC4
uniprot id: A0A096NZK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9555:CLCN4
gene id: 9555:CLCN4
uniprot id: A0A096NQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9555:ROM1
gene id: 9555:ROM1
uniprot id: A0A096NGZ2
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9555:ARMC8
gene id: 9555:ARMC8
uniprot id: A0A096N7B9
uniprot id: A0A096NGD7
uniprot id: A0A2I3LRM4
uniprot id: A0A2I3M3G8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:LOC101023558
gene id: 9555:LOC101023558
uniprot id: A0A2I3N1W5
names: Similarity
messages: Belongs to the LCE family.

9555:ADGRF5
gene id: 9555:ADGRF5
uniprot id: A0A096NIW5
uniprot id: A0A2I3MRN7
uniprot id: A0A2I3NHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9555:ABT1
gene id: 9555:ABT1
uniprot id: A9X182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9555:TFDP1
gene id: 9555:TFDP1
uniprot id: A0A096N2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:SUOX
gene id: 9555:SUOX
uniprot id: A0A2I3N7D0
uniprot id: A0A8I5NE17
names: Function
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.

9555:KPNB1
gene id: 9555:KPNB1
uniprot id: A0A096P541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9555:RAD18
gene id: 9555:RAD18
uniprot id: A0A096NUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9555:COMTD1
gene id: 9555:COMTD1
uniprot id: A0A096P4J2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9555:HSD17B12
gene id: 9555:HSD17B12
uniprot id: A0A096N4Y8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:DAXX
gene id: 9555:DAXX
uniprot id: A0A096NHI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

9555:PDE9A
gene id: 9555:PDE9A
uniprot id: A0A096NIS9
uniprot id: A0A2I3M0X7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:POLR2I
gene id: 9555:POLR2I
uniprot id: A0A0A0MV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9555:ZC3HAV1
gene id: 9555:ZC3HAV1
uniprot id: A0A096NY80
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:SEC31A
gene id: 9555:SEC31A
uniprot id: A0A096NWD8
uniprot id: A0A2I3M592
uniprot id: A0A2I3ME68
uniprot id: A0A2I3MWF7
uniprot id: A0A2I3MZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:HLCS
gene id: 9555:HLCS
uniprot id: A0A096NJ46
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9555:EIF4H
gene id: 9555:EIF4H
uniprot id: A0A096N2X1
uniprot id: A0A2I3NB98
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

9555:HES7
gene id: 9555:HES7
uniprot id: A0A096P2T5
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

9555:AHR
gene id: 9555:AHR
uniprot id: A0A096MVJ2
uniprot id: A0A8I5NZ99
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:FLOT1
gene id: 9555:FLOT1
uniprot id: A0A2I3LK29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9555:CKAP2L
gene id: 9555:CKAP2L
uniprot id: A0A096N4I7
names: Similarity
messages: Belongs to the CKAP2 family.

9555:RPA1
gene id: 9555:RPA1
uniprot id: A0A096P2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9555:OPN1LW
gene id: 9555:OPN1LW
uniprot id: A9CB54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9555:NKX2-1
gene id: 9555:NKX2-1
uniprot id: A0A096NUM8
uniprot id: A0A2I3LKG7
names: Subcellular Location Annotation
messages: Nucleus

9555:PSD
gene id: 9555:PSD
uniprot id: A0A2I3N7S1
names: Subcellular Location Annotation
messages: ruffle membrane

9555:FICD
gene id: 9555:FICD
uniprot id: A0A096MT37
names: Similarity
messages: Belongs to the fic family.

9555:RBM5
gene id: 9555:RBM5
uniprot id: A0A096MUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9555:TMTC3
gene id: 9555:TMTC3
uniprot id: A0A096NC38
uniprot id: A0A2I3MLN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9555:GRIK1
gene id: 9555:GRIK1
uniprot id: A0A2I3MFK0
uniprot id: A0A2I3MJ65
uniprot id: A0A2I3MXB9
uniprot id: A0A2I3N5T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:NKIRAS2
gene id: 9555:NKIRAS2
uniprot id: A0A2I3LMA9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9555:SLC9B2
gene id: 9555:SLC9B2
uniprot id: A0A096MYF0
names: Subcellular Location Annotation
messages: Membrane

9555:PSMD2
gene id: 9555:PSMD2
uniprot id: A0A2I3MC55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9555:CDCA5
gene id: 9555:CDCA5
uniprot id: A0A096N4G7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9555:CDS1
gene id: 9555:CDS1
uniprot id: A0A096N694
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9555:KCNC1
gene id: 9555:KCNC1
uniprot id: A0A096NU98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:LOC101016081
gene id: 9555:LOC101016081
uniprot id: A0A096P6A9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9555:DDX43
gene id: 9555:DDX43
uniprot id: A9X186
names: Similarity
messages: Belongs to the DEAD box helicase family.

9555:PTPRT
gene id: 9555:PTPRT
uniprot id: A0A2I3MC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9555:SF1
gene id: 9555:SF1
uniprot id: A0A096MPE2
uniprot id: A0A2I3NAC2
uniprot id: B0CM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9555:ZFHX2
gene id: 9555:ZFHX2
uniprot id: A0A096NX36
names: Subcellular Location Annotation
messages: Nucleus

9555:FLVCR2
gene id: 9555:FLVCR2
uniprot id: A0A096NS55
names: Subcellular Location Annotation
messages: Membrane

9555:YRDC
gene id: 9555:YRDC
uniprot id: A0A096MYP7
names: Similarity
messages: Belongs to the SUA5 family.

9555:ADRA2C
gene id: 9555:ADRA2C
uniprot id: A0A096NA11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:DLGAP4
gene id: 9555:DLGAP4
uniprot id: A0A2I3MTV2
names: Similarity
messages: Belongs to the SAPAP family.

9555:PELP1
gene id: 9555:PELP1
uniprot id: A0A096P2G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

9555:SH2B1
gene id: 9555:SH2B1
uniprot id: A0A096NHN2
uniprot id: A0A2I3M9E3
names: Similarity
messages: Belongs to the SH2B adapter family.

9555:MAFB
gene id: 9555:MAFB
uniprot id: A0A096NXE7
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

9555:RFC5
gene id: 9555:RFC5
uniprot id: A0A096MP38
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9555:USP7
gene id: 9555:USP7
uniprot id: A0A2I3LZT9
uniprot id: A0A2I3MYJ1
names: Similarity
messages: Belongs to the peptidase C19 family.

9555:SEMA3D
gene id: 9555:SEMA3D
uniprot id: A0A096MZM4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:EGR1
gene id: 9555:EGR1
uniprot id: A0A2I3LF48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9555:WNT5A
gene id: 9555:WNT5A
uniprot id: A0A096MZ93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:CTNNBIP1
gene id: 9555:CTNNBIP1
uniprot id: A0A2I3MTA7
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9555:WDR35
gene id: 9555:WDR35
uniprot id: A0A096NQ94
uniprot id: A0A2I3MP82
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9555:PIGS
gene id: 9555:PIGS
uniprot id: A0A096P397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:FBXO46
gene id: 9555:FBXO46
uniprot id: A0A0A0MWI8
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9555:MEIS1
gene id: 9555:MEIS1
uniprot id: A0A8I5NIK4
uniprot id: A0A8I5R6B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9555:NFX1
gene id: 9555:NFX1
uniprot id: A0A096P1C5
uniprot id: A0A2I3LZC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9555:HYAL3
gene id: 9555:HYAL3
uniprot id: A0A096MWQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Membrane
messages: acrosome

9555:RSBN1
gene id: 9555:RSBN1
uniprot id: A0A096N6J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9555:PSMA7
gene id: 9555:PSMA7
uniprot id: A0A096NND3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9555:CSGALNACT2
gene id: 9555:CSGALNACT2
uniprot id: A0A096P477
uniprot id: A0A2I3M2J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9555:SGTA
gene id: 9555:SGTA
uniprot id: A0A0A0MUS7
names: Similarity
messages: Belongs to the SGT family.

9555:PURA
gene id: 9555:PURA
uniprot id: A0A8I5NJD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9555:F3
gene id: 9555:F3
uniprot id: A0A096MM85
uniprot id: A0A2I3LSJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9555:SAP30L
gene id: 9555:SAP30L
uniprot id: A0A096MR33
names: Similarity
messages: Belongs to the SAP30 family.

9555:TRDMT1
gene id: 9555:TRDMT1
uniprot id: A0A096MXD0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9555:ACKR3
gene id: 9555:ACKR3
uniprot id: A0A096MKX4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:CLVS2
gene id: 9555:CLVS2
uniprot id: A0A096MV83
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9555:PSMD9
gene id: 9555:PSMD9
uniprot id: A0A096N8L3
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9555:FAM168A
gene id: 9555:FAM168A
uniprot id: A0A096NAK6
uniprot id: A0A2I3MV11
uniprot id: A0A2I3NBV3
names: Similarity
messages: Belongs to the FAM168 family.

9555:LAMP1
gene id: 9555:LAMP1
uniprot id: A0A096MXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9555:DDX49
gene id: 9555:DDX49
uniprot id: A0A0A0MVX5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9555:MKX
gene id: 9555:MKX
uniprot id: A0A096P3V6
names: Subcellular Location Annotation
messages: Nucleus

9555:UBE2B
gene id: 9555:UBE2B
uniprot id: A0A096MMR7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:GCFC2
gene id: 9555:GCFC2
uniprot id: A0A096NZ45
names: Similarity
messages: Belongs to the GCF family.

9555:CACNA2D4
gene id: 9555:CACNA2D4
uniprot id: A0A096N5V2
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9555:GPX7
gene id: 9555:GPX7
uniprot id: A0A096N2H1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9555:CITED4
gene id: 9555:CITED4
uniprot id: A0A096NWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9555:GABRE
gene id: 9555:GABRE
uniprot id: A0A8I5NNU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:ARL5B
gene id: 9555:ARL5B
uniprot id: A0A096P3N4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9555:FN3KRP
gene id: 9555:FN3KRP
uniprot id: A0A096NTQ1
names: Similarity
messages: Belongs to the fructosamine kinase family.

9555:DGUOK
gene id: 9555:DGUOK
uniprot id: A0A096NF31
uniprot id: A0A2I3NCN1
names: Similarity
messages: Belongs to the DCK/DGK family.

9555:CCL25
gene id: 9555:CCL25
uniprot id: A0A8I5NYA0
names: Subcellular Location Annotation
messages: Secreted

9555:KCNS3
gene id: 9555:KCNS3
uniprot id: A0A096NP34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:MRPS15
gene id: 9555:MRPS15
uniprot id: A0A096MU85
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9555:DTX1
gene id: 9555:DTX1
uniprot id: A0A096MUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9555:ASCC3
gene id: 9555:ASCC3
uniprot id: A0A096MQ75
names: Similarity
messages: Belongs to the helicase family.

9555:CRISP2
gene id: 9555:CRISP2
uniprot id: A0A096NJ01
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:POLR2F
gene id: 9555:POLR2F
uniprot id: A0A2I3LN40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9555:CAMSAP1
gene id: 9555:CAMSAP1
uniprot id: A0A096NRT9
uniprot id: A0A2I3LU80
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9555:EFNB3
gene id: 9555:EFNB3
uniprot id: A0A8I5NRR2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SELENOT
gene id: 9555:SELENOT
uniprot id: A0A8I5N335
names: Similarity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.

9555:TEAD1
gene id: 9555:TEAD1
uniprot id: A0A2I3N5R3
names: Subcellular Location Annotation
messages: Nucleus

9555:OAZ3
gene id: 9555:OAZ3
uniprot id: A0A096NYU8
names: Similarity
messages: Belongs to the ODC antizyme family.

9555:LOC101004009
gene id: 9555:LOC101004009
uniprot id: A0A096MR93
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9555:STXBP5
gene id: 9555:STXBP5
uniprot id: A0A096N5B6
uniprot id: A0A2I3M5Y0
uniprot id: A0A2I3MTG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:IFI30
gene id: 9555:IFI30
uniprot id: A0A2I3MB38
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9555:IMMT
gene id: 9555:IMMT
uniprot id: A0A096NZY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9555:KRT74
gene id: 9555:KRT74
uniprot id: A0A096MRB4
names: Similarity
messages: Belongs to the intermediate filament family.

9555:UGT3A1
gene id: 9555:UGT3A1
uniprot id: A0A2I3LVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:EPHB1
gene id: 9555:EPHB1
uniprot id: A0A096MU83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9555:NELFCD
gene id: 9555:NELFCD
uniprot id: A0A096NNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9555:SPAG7
gene id: 9555:SPAG7
uniprot id: A0A2I3LJY8
names: Subcellular Location Annotation
messages: Nucleus

9555:TPPP2
gene id: 9555:TPPP2
uniprot id: A0A096NNN5
names: Similarity
messages: Belongs to the TPPP family.

9555:ERG
gene id: 9555:ERG
uniprot id: A0A096NJ30
uniprot id: A0A2I3M4W8
uniprot id: A0A2I3M684
uniprot id: A0A2I3MK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:PGM2L1
gene id: 9555:PGM2L1
uniprot id: A0A096MUB3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9555:ASB10
gene id: 9555:ASB10
uniprot id: A0A2I3N427
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:CEP19
gene id: 9555:CEP19
uniprot id: A0A096N398
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9555:OLFML2A
gene id: 9555:OLFML2A
uniprot id: A0A096P0L8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:N4BP3
gene id: 9555:N4BP3
uniprot id: A0A096NAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9555:MPP6
gene id: 9555:MPP6
uniprot id: A0A096NW04
uniprot id: A0A2I3LY71
names: Similarity
messages: Belongs to the MAGUK family.

9555:DSC2
gene id: 9555:DSC2
uniprot id: A0A096MSN6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9555:SLC33A1
gene id: 9555:SLC33A1
uniprot id: A0A096NGR1
names: Subcellular Location Annotation
messages: Membrane

9555:TM9SF1
gene id: 9555:TM9SF1
uniprot id: A0A096NXA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9555:ELAC2
gene id: 9555:ELAC2
uniprot id: A0A2I3MFP2
names: Similarity
messages: Belongs to the RNase Z family.

9555:PRMT5
gene id: 9555:PRMT5
uniprot id: A0A096N5H2
uniprot id: A0A2I3LK67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9555:SRPRA
gene id: 9555:SRPRA
uniprot id: A0A096N4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9555:DIPK1A
gene id: 9555:DIPK1A
uniprot id: A0A096MKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9555:DDIT4
gene id: 9555:DDIT4
uniprot id: A0A2I3MVE7
names: Similarity
messages: Belongs to the DDIT4 family.

9555:ROCK2
gene id: 9555:ROCK2
uniprot id: A0A096NJ50
uniprot id: A0A096NJ57
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

9555:VAMP4
gene id: 9555:VAMP4
uniprot id: A0A096N8H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9555:MECP2
gene id: 9555:MECP2
uniprot id: A0A096MNY8
uniprot id: A0A2I3N886
names: Function
names: Subcellular Location Annotation
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Nucleus

9555:DEFB118
gene id: 9555:DEFB118
uniprot id: A0A096NV16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:NT5C3A
gene id: 9555:NT5C3A
uniprot id: A0A096P041
uniprot id: A0A2I3MQN2
uniprot id: A0A8I5N997
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9555:CCR9
gene id: 9555:CCR9
uniprot id: A0A096NQ44
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:GALT
gene id: 9555:GALT
uniprot id: A0A2I3N548
uniprot id: A0A2I3NDM2
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9555:XIAP
gene id: 9555:XIAP
uniprot id: A0A096NAP9
names: Similarity
messages: Belongs to the IAP family.

9555:TEX261
gene id: 9555:TEX261
uniprot id: A0A096NW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9555:FNIP2
gene id: 9555:FNIP2
uniprot id: A0A2I3LSX4
uniprot id: A0A2I3MXR8
uniprot id: A0A2I3N7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9555:BMP10
gene id: 9555:BMP10
uniprot id: A0A8I5N5C9
names: Similarity
messages: Belongs to the TGF-beta family.

9555:XKR5
gene id: 9555:XKR5
uniprot id: A0A096N423
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9555:MYADM
gene id: 9555:MYADM
uniprot id: A0A0A0MVT1
names: Subcellular Location Annotation
messages: Membrane

9555:FAM110B
gene id: 9555:FAM110B
uniprot id: A0A096N6K3
names: Similarity
messages: Belongs to the FAM110 family.

9555:HSD17B4
gene id: 9555:HSD17B4
uniprot id: A0A096MSY0
names: Subcellular Location Annotation
messages: Peroxisome

9555:KLHL40
gene id: 9555:KLHL40
uniprot id: A0A096MTP7
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9555:MTNR1B
gene id: 9555:MTNR1B
uniprot id: A0A096NB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SNTB2
gene id: 9555:SNTB2
uniprot id: A0A096NW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9555:VWCE
gene id: 9555:VWCE
uniprot id: A0A096NGZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CORO1A
gene id: 9555:CORO1A
uniprot id: A0A096NHR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9555:ABI2
gene id: 9555:ABI2
uniprot id: A0A096MZ16
uniprot id: A0A2I3ND82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9555:RNPC3
gene id: 9555:RNPC3
uniprot id: A0A096MRG8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9555:TMEM161B
gene id: 9555:TMEM161B
uniprot id: A0A8I5MVQ4
uniprot id: A0A8I5N515
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9555:AURKA
gene id: 9555:AURKA
uniprot id: A0A096NNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9555:PGM2
gene id: 9555:PGM2
uniprot id: A0A096NZM9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9555:ALOX5AP
gene id: 9555:ALOX5AP
uniprot id: A0A096MLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SLC15A3
gene id: 9555:SLC15A3
uniprot id: A0A096NET2
uniprot id: A0A8I5N644
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9555:TRIM63
gene id: 9555:TRIM63
uniprot id: A0A096MSS5
names: Subcellular Location Annotation
messages: Nucleus

9555:GPR65
gene id: 9555:GPR65
uniprot id: A0A2I3N193
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:OXCT1
gene id: 9555:OXCT1
uniprot id: A0A096MW68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9555:PPP2R3C
gene id: 9555:PPP2R3C
uniprot id: A0A096NUL0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ZIC4
gene id: 9555:ZIC4
uniprot id: A0A096N2D8
uniprot id: A0A2I3M7K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9555:LOC103883547
gene id: 9555:LOC103883547
uniprot id: A0A096N7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:VPS72
gene id: 9555:VPS72
uniprot id: A9X196
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9555:UBE2T
gene id: 9555:UBE2T
uniprot id: A0A096NB93
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:CBLIF
gene id: 9555:CBLIF
uniprot id: A0A096MZE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9555:RPE
gene id: 9555:RPE
uniprot id: A0A2I3LZZ1
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9555:CCL13
gene id: 9555:CCL13
uniprot id: A0A096P3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:AQP2
gene id: 9555:AQP2
uniprot id: A0A096MRJ3
uniprot id: A0A2I3MR46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9555:LDB2
gene id: 9555:LDB2
uniprot id: A0A2I3LUR7
names: Similarity
messages: Belongs to the LDB family.

9555:PGLYRP1
gene id: 9555:PGLYRP1
uniprot id: A0A8I5N8A2
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9555:POU4F2
gene id: 9555:POU4F2
uniprot id: A0A8I5N472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9555:RAD9A
gene id: 9555:RAD9A
uniprot id: A0A096MM69
names: Similarity
messages: Belongs to the rad9 family.

9555:LZTS2
gene id: 9555:LZTS2
uniprot id: A0A096P6A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9555:RPS6KA5
gene id: 9555:RPS6KA5
uniprot id: A0A2I3MGX6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9555:LOC101023703
gene id: 9555:LOC101023703
uniprot id: A0A8I5NAJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:TRMT61A
gene id: 9555:TRMT61A
uniprot id: A0A096NJY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9555:YJU2
gene id: 9555:YJU2
uniprot id: A0A0A0MUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9555:PRKACG
gene id: 9555:PRKACG
uniprot id: A0A8I5NND5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9555:MZF1
gene id: 9555:MZF1
uniprot id: A0A0A0MVV8
names: Subcellular Location Annotation
messages: Nucleus

9555:INTS8
gene id: 9555:INTS8
uniprot id: A0A096MZW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9555:GPR182
gene id: 9555:GPR182
uniprot id: A0A096MLZ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:TRIM45
gene id: 9555:TRIM45
uniprot id: A0A096NE79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9555:CGN
gene id: 9555:CGN
uniprot id: A9X1A5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cingulin family.
messages: Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
messages: Homodimer (By similarity). Interacts with TJP1/ZO1 and SPEF1 (By similarity).
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: tight junction

9555:RHBDL3
gene id: 9555:RHBDL3
uniprot id: A0A096P3R8
uniprot id: A0A2I3LLH7
uniprot id: A0A8I5ND95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9555:DEGS1
gene id: 9555:DEGS1
uniprot id: A0A2I3ND51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

9555:LOC101016814
gene id: 9555:LOC101016814
uniprot id: A0A2I3N7A7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9555:DZIP1
gene id: 9555:DZIP1
uniprot id: A0A096NYW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9555:COMP
gene id: 9555:COMP
uniprot id: A0A0A0MV46
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CD8B
gene id: 9555:CD8B
uniprot id: A0A096MR88
uniprot id: A0A2I3M5T5
names: Subcellular Location Annotation
messages: Membrane

9555:NETO2
gene id: 9555:NETO2
uniprot id: A0A2I3M0S5
uniprot id: A0A2I3NCW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PLRG1
gene id: 9555:PLRG1
uniprot id: A0A2I3LFX3
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9555:CORO6
gene id: 9555:CORO6
uniprot id: A0A2I3MZU8
names: Similarity
messages: Belongs to the WD repeat coronin family.

9555:GMFB
gene id: 9555:GMFB
uniprot id: A0A2I3MS64
uniprot id: A0A2I3MY40
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9555:TMEM126A
gene id: 9555:TMEM126A
uniprot id: A0A096N341
names: Subcellular Location Annotation
messages: Membrane

9555:HDAC8
gene id: 9555:HDAC8
uniprot id: A0A096MM52
uniprot id: A0A2I3M3F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Nucleus

9555:DRC1
gene id: 9555:DRC1
uniprot id: A0A096NR04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

9555:PLSCR1
gene id: 9555:PLSCR1
uniprot id: A0A096MSZ6
uniprot id: A0A8I5MV85
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9555:PURG
gene id: 9555:PURG
uniprot id: A0A096NYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9555:RBM15B
gene id: 9555:RBM15B
uniprot id: A0A096NXR2
names: Similarity
messages: Belongs to the RRM Spen family.

9555:ZNF445
gene id: 9555:ZNF445
uniprot id: A0A096N7E1
names: Subcellular Location Annotation
messages: Nucleus

9555:CDC42EP1
gene id: 9555:CDC42EP1
uniprot id: A0A096NJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9555:PYROXD1
gene id: 9555:PYROXD1
uniprot id: A0A096N500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9555:EBF1
gene id: 9555:EBF1
uniprot id: A0A2I3N9Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9555:STXBP5L
gene id: 9555:STXBP5L
uniprot id: A0A096MLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:OGDHL
gene id: 9555:OGDHL
uniprot id: A0A096P498
uniprot id: A0A2I3LSI8
uniprot id: A0A2I3MP74
uniprot id: A0A2I3MQ00
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9555:OLR136
gene id: 9555:OLR136
uniprot id: A9L8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SLC10A2
gene id: 9555:SLC10A2
uniprot id: A0A8I5MYR5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9555:LOC100998573
gene id: 9555:LOC100998573
uniprot id: A0A096N8F0
names: Subcellular Location Annotation
messages: Membrane

9555:KATNB1
gene id: 9555:KATNB1
uniprot id: A0A096NIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9555:USP39
gene id: 9555:USP39
uniprot id: A0A096NZV3
names: Subcellular Location Annotation
messages: Nucleus

9555:GPER1
gene id: 9555:GPER1
uniprot id: A0A096N0M3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:TIGD6
gene id: 9555:TIGD6
uniprot id: A0A096NB07
names: Subcellular Location Annotation
messages: Nucleus

9555:CACNB2
gene id: 9555:CACNB2
uniprot id: A0A2I3LJH8
uniprot id: A0A2I3LTW3
uniprot id: A0A2I3M014
uniprot id: A0A2I3ML61
uniprot id: A0A2I3MT39
uniprot id: A0A2I3MX69
uniprot id: A0A2I3N3W9
uniprot id: A0A2I3N3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9555:TUFM
gene id: 9555:TUFM
uniprot id: A0A096NHN3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9555:NUP35
gene id: 9555:NUP35
uniprot id: A0A096NFU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9555:CDK19
gene id: 9555:CDK19
uniprot id: A0A096N1F0
uniprot id: A0A096NFM6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:STXBP1
gene id: 9555:STXBP1
uniprot id: A0A096P203
uniprot id: A0A2I3MJQ0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9555:NPM3
gene id: 9555:NPM3
uniprot id: A0A096P6C6
names: Similarity
messages: Belongs to the nucleoplasmin family.

9555:SCUBE2
gene id: 9555:SCUBE2
uniprot id: A0A096MW76
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:OCIAD1
gene id: 9555:OCIAD1
uniprot id: A0A096NQ24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9555:ATRNL1
gene id: 9555:ATRNL1
uniprot id: A0A096NTS9
uniprot id: A0A2I3MW07
uniprot id: A0A8I5NAS9
uniprot id: A0A8I5NPZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:COPE
gene id: 9555:COPE
uniprot id: A0A0A0MTZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9555:DMAP1
gene id: 9555:DMAP1
uniprot id: A0A096N2L8
names: Subcellular Location Annotation
messages: Nucleus

9555:SSX2IP
gene id: 9555:SSX2IP
uniprot id: A0A8I5N751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9555:STUM
gene id: 9555:STUM
uniprot id: A0A096NF61
names: Subcellular Location Annotation
messages: Membrane

9555:SORCS3
gene id: 9555:SORCS3
uniprot id: A0A096P6J4
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9555:TRPM6
gene id: 9555:TRPM6
uniprot id: A0A096P1S7
uniprot id: A0A2I3MUT0
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9555:THOC5
gene id: 9555:THOC5
uniprot id: A0A096NJE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9555:DPAGT1
gene id: 9555:DPAGT1
uniprot id: A0A096N3W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:RETREG1
gene id: 9555:RETREG1
uniprot id: A0A096MVQ8
uniprot id: A0A2I3LF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9555:GPR50
gene id: 9555:GPR50
uniprot id: A0A096N6B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:LYZ
gene id: 9555:LYZ
uniprot id: P61629
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
messages: Monomer.
messages: Secreted

9555:CAMK1D
gene id: 9555:CAMK1D
uniprot id: A0A096P3F8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:LOC101005729
gene id: 9555:LOC101005729
uniprot id: A0A2I3MQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9555:YIPF1
gene id: 9555:YIPF1
uniprot id: A0A096NGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9555:RAX2
gene id: 9555:RAX2
uniprot id: A0A0A0MW01
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CRX.
messages: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
messages: Nucleus

9555:KCTD7
gene id: 9555:KCTD7
uniprot id: A0A8I5NUV9
names: Subcellular Location Annotation
messages: Cell membrane

9555:ELOC
gene id: 9555:ELOC
uniprot id: A0A2I3NGA9
names: Similarity
messages: Belongs to the SKP1 family.

9555:NPR1
gene id: 9555:NPR1
uniprot id: A0A096NAX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9555:ABLIM3
gene id: 9555:ABLIM3
uniprot id: A0A2I3LK69
names: Subcellular Location Annotation
messages: Cytoplasm

9555:CDK10
gene id: 9555:CDK10
uniprot id: A0A096MNE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CPLX2
gene id: 9555:CPLX2
uniprot id: A0A096MLC6
uniprot id: A0A2I3LG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9555:ANKZF1
gene id: 9555:ANKZF1
uniprot id: A0A096NDX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9555:CASC4
gene id: 9555:CASC4
uniprot id: A0A096NLY1
uniprot id: A0A2I3M689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9555:EML5
gene id: 9555:EML5
uniprot id: A0A096NW69
uniprot id: A0A2I3N287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

9555:FAM120A
gene id: 9555:FAM120A
uniprot id: A0A096P250
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9555:TSPAN7
gene id: 9555:TSPAN7
uniprot id: A0A2I3LCB5
uniprot id: A0A2I3LG35
uniprot id: A0A2I3MAX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:IPO5
gene id: 9555:IPO5
uniprot id: A0A096MPU2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ACO1
gene id: 9555:ACO1
uniprot id: A0A096P1E0
uniprot id: A0A8I5NLS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9555:RPL10L
gene id: 9555:RPL10L
uniprot id: A0A8I5QZM7
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9555:EXOC4
gene id: 9555:EXOC4
uniprot id: A0A2I3LWZ2
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9555:LOC101021556
gene id: 9555:LOC101021556
uniprot id: A0A096MLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TIMM17B
gene id: 9555:TIMM17B
uniprot id: A0A096MXT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9555:ACTR5
gene id: 9555:ACTR5
uniprot id: A0A096NXF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

9555:HSPA14
gene id: 9555:HSPA14
uniprot id: A0A096P3I0
uniprot id: A0A2I3LTR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9555:QPCT
gene id: 9555:QPCT
uniprot id: A0A096NRF7
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9555:UGT8
gene id: 9555:UGT8
uniprot id: A0A096MR78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:SPSB3
gene id: 9555:SPSB3
uniprot id: A0A096NKX2
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9555:MCUR1
gene id: 9555:MCUR1
uniprot id: A0A096NL14
names: Similarity
messages: Belongs to the CCDC90 family.

9555:ELAVL4
gene id: 9555:ELAVL4
uniprot id: A0A096MTT3
uniprot id: A0A2I3LD78
uniprot id: A0A2I3MUV9
uniprot id: A0A2I3N449
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9555:KPNA3
gene id: 9555:KPNA3
uniprot id: A0A096N604
uniprot id: A0A096NP23
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9555:GOT1
gene id: 9555:GOT1
uniprot id: A0A096P648
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9555:HSCB
gene id: 9555:HSCB
uniprot id: A0A8I5NKZ4
names: Similarity
messages: Belongs to the HscB family.

9555:SCARA5
gene id: 9555:SCARA5
uniprot id: A0A096MV66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9555:SEC61G
gene id: 9555:SEC61G
uniprot id: A0A096NF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:CTSD
gene id: 9555:CTSD
uniprot id: A9L947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9555:DTD1
gene id: 9555:DTD1
uniprot id: A0A2I3N5U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9555:UPF1
gene id: 9555:UPF1
uniprot id: A0A2I3MB73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9555:FAM167A
gene id: 9555:FAM167A
uniprot id: A0A096NPT1
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9555:MOCS3
gene id: 9555:MOCS3
uniprot id: A0A096N6H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9555:CCM2L
gene id: 9555:CCM2L
uniprot id: A0A8I5N2R4
names: Similarity
messages: Belongs to the CCM2 family.

9555:HRH3
gene id: 9555:HRH3
uniprot id: A0A8I5R123
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:BAAT
gene id: 9555:BAAT
uniprot id: A0A2I3M7H0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9555:KCNS1
gene id: 9555:KCNS1
uniprot id: A4K2M4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.
messages: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

9555:SLC30A2
gene id: 9555:SLC30A2
uniprot id: A0A2I3MA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9555:MFAP5
gene id: 9555:MFAP5
uniprot id: A0A2I3MPU3
uniprot id: A0A8I5ND55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9555:ADGRL1
gene id: 9555:ADGRL1
uniprot id: A0A0A0MWS3
names: Subcellular Location Annotation
messages: Membrane

9555:MRPL17
gene id: 9555:MRPL17
uniprot id: A0A096NDY4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9555:P2RX3
gene id: 9555:P2RX3
uniprot id: A0A2I3LT80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9555:C2H3orf70
gene id: 9555:C2H3orf70
uniprot id: A0A096NC90
names: Similarity
messages: Belongs to the UPF0524 family.

9555:STK11IP
gene id: 9555:STK11IP
uniprot id: B0CM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9555:PEX3
gene id: 9555:PEX3
uniprot id: A0A096N3Y6
uniprot id: A0A2I3LS74
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9555:LOC101016349
gene id: 9555:LOC101016349
uniprot id: A0A2I3N161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:ACTR8
gene id: 9555:ACTR8
uniprot id: A0A096N8J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9555:PDE1B
gene id: 9555:PDE1B
uniprot id: A0A096NAN6
uniprot id: A0A2I3MQ92
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:SCUBE3
gene id: 9555:SCUBE3
uniprot id: A0A096NHM9
uniprot id: A0A2I3MP95
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:FECH
gene id: 9555:FECH
uniprot id: A0A096MPX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9555:PDGFB
gene id: 9555:PDGFB
uniprot id: A0A2I3NCD7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9555:MTNR1A
gene id: 9555:MTNR1A
uniprot id: A0A096MY52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9555:APOC1
gene id: 9555:APOC1
uniprot id: A0A096P2H7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.
messages: Belongs to the apolipoprotein C1 family.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9555:DDX4
gene id: 9555:DDX4
uniprot id: A0A096MTZ9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9555:LBH
gene id: 9555:LBH
uniprot id: A0A096N1V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9555:LOC101015090
gene id: 9555:LOC101015090
uniprot id: A0A2I3MGF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9555:ERC1
gene id: 9555:ERC1
uniprot id: A0A2I3LJ26
uniprot id: A0A2I3LPL2
uniprot id: A0A2I3MJ01
names: Subcellular Location Annotation
messages: Cytoplasm

9555:AFF4
gene id: 9555:AFF4
uniprot id: A0A8I5N6A9
uniprot id: A9CB20
names: Similarity
messages: Belongs to the AF4 family.

9555:TNFSF10
gene id: 9555:TNFSF10
uniprot id: A0A096MXB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9555:CLRN3
gene id: 9555:CLRN3
uniprot id: A0A096NSS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9555:PLA2G4E
gene id: 9555:PLA2G4E
uniprot id: A0A096NTR2
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9555:PGC
gene id: 9555:PGC
uniprot id: A0A2I3MH01
uniprot id: A8MN26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Secreted

9555:SH3BP4
gene id: 9555:SH3BP4
uniprot id: A0A096N1P2
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9555:ATG16L2
gene id: 9555:ATG16L2
uniprot id: A0A096NYA1
uniprot id: A0A2I3MFZ2
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9555:CA5B
gene id: 9555:CA5B
uniprot id: A0A096NAK3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9555:LOC101022282
gene id: 9555:LOC101022282
uniprot id: A0A096P1U3
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9555:NMNAT2
gene id: 9555:NMNAT2
uniprot id: A0A096NQK4
uniprot id: A0A2I3NCD3
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9555:TLR10
gene id: 9555:TLR10
uniprot id: A0A2I3LXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9555:TMCC2
gene id: 9555:TMCC2
uniprot id: A0A096N2U0
uniprot id: A0A2I3LE58
names: Similarity
messages: Belongs to the TEX28 family.

9555:SLC46A2
gene id: 9555:SLC46A2
uniprot id: A0A096P0U8
names: Subcellular Location Annotation
messages: Membrane

9555:SLC35F6
gene id: 9555:SLC35F6
uniprot id: A0A2I3LT70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9555:FUNDC2
gene id: 9555:FUNDC2
uniprot id: A0A2I3NG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9555:CNIH2
gene id: 9555:CNIH2
uniprot id: A0A096MNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9555:KCNA5
gene id: 9555:KCNA5
uniprot id: A0A096N9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9555:HS6ST3
gene id: 9555:HS6ST3
uniprot id: A0A096NEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9555:CABS1
gene id: 9555:CABS1
uniprot id: A0A8I5R218
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9555:SOAT2
gene id: 9555:SOAT2
uniprot id: A0A096N7Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:HMGB3
gene id: 9555:HMGB3
uniprot id: A0A096N0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9555:KRT79
gene id: 9555:KRT79
uniprot id: A0A096NEU4
names: Similarity
messages: Belongs to the intermediate filament family.

9555:EDC3
gene id: 9555:EDC3
uniprot id: A0A096NMR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9555:LOC101020591
gene id: 9555:LOC101020591
uniprot id: A0A2I3N5I0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9555:TRADD
gene id: 9555:TRADD
uniprot id: A0A096NJA9
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9555:TMEM14A
gene id: 9555:TMEM14A
uniprot id: A0A096NJ55
names: Similarity
messages: Belongs to the TMEM14 family.

9555:STAT3
gene id: 9555:STAT3
uniprot id: A0A096P5S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9555:IPPK
gene id: 9555:IPPK
uniprot id: A0A096P240
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9555:FLCN
gene id: 9555:FLCN
uniprot id: A0A8I5R2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9555:XCR1
gene id: 9555:XCR1
uniprot id: A0A096N733
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:PLPP5
gene id: 9555:PLPP5
uniprot id: A0A2I3LWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9555:CRISP3
gene id: 9555:CRISP3
uniprot id: A0A096NJ02
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GRB10
gene id: 9555:GRB10
uniprot id: A0A096N1U5
uniprot id: A0A2I3M4F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9555:H1-5
gene id: 9555:H1-5
uniprot id: A0A096NCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9555:BLK
gene id: 9555:BLK
uniprot id: A0A096NWY5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:LMOD1
gene id: 9555:LMOD1
uniprot id: A0A096N290
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9555:SPSB1
gene id: 9555:SPSB1
uniprot id: A0A2I3N993
names: Similarity
messages: Belongs to the SPSB family.

9555:AGO4
gene id: 9555:AGO4
uniprot id: A0A096N7N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9555:SYBU
gene id: 9555:SYBU
uniprot id: A0A096MYQ0
uniprot id: A0A2I3LI13
uniprot id: A0A8I5NHS4
names: Subcellular Location Annotation
messages: Membrane

9555:WEE1
gene id: 9555:WEE1
uniprot id: A0A096MRA8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9555:PPP2R5E
gene id: 9555:PPP2R5E
uniprot id: A0A096NVK1
uniprot id: A0A2I3LIN2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9555:SLC6A11
gene id: 9555:SLC6A11
uniprot id: A0A2I3LFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9555:ADGRG1
gene id: 9555:ADGRG1
uniprot id: A0A096NIT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9555:EIF1AX
gene id: 9555:EIF1AX
uniprot id: A0A2I3LWL6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9555:RHBG
gene id: 9555:RHBG
uniprot id: A0A096MU04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9555:NCSTN
gene id: 9555:NCSTN
uniprot id: A0A096N6X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9555:FAM135A
gene id: 9555:FAM135A
uniprot id: A0A096N1W2
uniprot id: A0A2I3M8F9
uniprot id: A0A2I3MXX5
uniprot id: A0A8I5R9S3
names: Similarity
messages: Belongs to the FAM135 family.

9555:LOC100998364
gene id: 9555:LOC100998364
uniprot id: A0A2I3LD30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9555:HFE
gene id: 9555:HFE
uniprot id: A0A8I5NMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Binds TFR through the extracellular domain in a pH-dependent manner.
messages: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
messages: Cell membrane

9555:PIH1D3
gene id: 9555:PIH1D3
uniprot id: A0A096MQV1
names: Similarity
messages: Belongs to the PIH1 family.

9555:NUS1
gene id: 9555:NUS1
uniprot id: A0A096N5F7
uniprot id: A0A8I5N6M2
names: Similarity
messages: Belongs to the UPP synthase family.

9555:CEBPZ
gene id: 9555:CEBPZ
uniprot id: A0A096NDN3
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9555:PMP2
gene id: 9555:PMP2
uniprot id: A0A8I5NV24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9555:ST6GALNAC5
gene id: 9555:ST6GALNAC5
uniprot id: A0A2I3N4P5
uniprot id: A0A2I3NCF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:TCEA3
gene id: 9555:TCEA3
uniprot id: A0A096MZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9555:MAB21L2
gene id: 9555:MAB21L2
uniprot id: A0A096ML90
uniprot id: A0A096MXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9555:RAD23B
gene id: 9555:RAD23B
uniprot id: A0A096P0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9555:SAP18
gene id: 9555:SAP18
uniprot id: A0A096NFK1
names: Similarity
messages: Belongs to the SAP18 family.

9555:STK32A
gene id: 9555:STK32A
uniprot id: A0A096NY11
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:CHMP4B
gene id: 9555:CHMP4B
uniprot id: A0A096NUU1
names: Similarity
messages: Belongs to the SNF7 family.

9555:LOC101022644
gene id: 9555:LOC101022644
uniprot id: A0A096NQ36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:DNAJC25
gene id: 9555:DNAJC25
uniprot id: A0A8I5N8I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9555:RRAGC
gene id: 9555:RRAGC
uniprot id: A0A096MR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9555:DYRK1B
gene id: 9555:DYRK1B
uniprot id: A0A0A0MUR9
uniprot id: A0A2I3MV23
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9555:CCR5
gene id: 9555:CCR5
uniprot id: Q9XT13
names: Similarity
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.

9555:CAMK2N2
gene id: 9555:CAMK2N2
uniprot id: A0A2I3LWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9555:PANX2
gene id: 9555:PANX2
uniprot id: A0A096NKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9555:HTRA1
gene id: 9555:HTRA1
uniprot id: A0A096NU19
names: Similarity
messages: Belongs to the peptidase S1C family.

9555:C9H12orf43
gene id: 9555:C9H12orf43
uniprot id: A0A096NEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9555:ATF4
gene id: 9555:ATF4
uniprot id: A0A096NK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9555:PENK
gene id: 9555:PENK
uniprot id: A0A096N787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9555:ELF5
gene id: 9555:ELF5
uniprot id: A0A096N9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:AP2A1
gene id: 9555:AP2A1
uniprot id: A0A0A0MUL4
uniprot id: A0A2I3LTA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9555:YARS1
gene id: 9555:YARS1
uniprot id: A0A096N3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9555:TOM1L1
gene id: 9555:TOM1L1
uniprot id: A0A096P4N8
names: Similarity
messages: Belongs to the TOM1 family.

9555:EMX1
gene id: 9555:EMX1
uniprot id: A0A096N253
names: Subcellular Location Annotation
messages: Nucleus

9555:LOC101018921
gene id: 9555:LOC101018921
uniprot id: A0A0A0MUN6
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9555:NDST3
gene id: 9555:NDST3
uniprot id: A0A096MX80
uniprot id: A0A2I3M669
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9555:HINT2
gene id: 9555:HINT2
uniprot id: A0A096P167
names: Similarity
messages: Belongs to the HINT family.

9555:LAMB2
gene id: 9555:LAMB2
uniprot id: A0A096MUU2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9555:SLC17A5
gene id: 9555:SLC17A5
uniprot id: A0A8I5NTK8
uniprot id: A9X190
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101013836
gene id: 9555:LOC101013836
uniprot id: A0A096N7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:NOP16
gene id: 9555:NOP16
uniprot id: A0A2I3N4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9555:SH3BGRL2
gene id: 9555:SH3BGRL2
uniprot id: A0A096NPI1
names: Similarity
messages: Belongs to the SH3BGR family.

9555:SFTPD
gene id: 9555:SFTPD
uniprot id: A0A096P4G4
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9555:GLIPR1L1
gene id: 9555:GLIPR1L1
uniprot id: A0A2I3LHE1
uniprot id: A0A2I3MY76
names: Similarity
messages: Belongs to the CRISP family.

9555:FZD7
gene id: 9555:FZD7
uniprot id: A0A096N7F2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TRAM1
gene id: 9555:TRAM1
uniprot id: A0A096MZ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9555:FAM91A1
gene id: 9555:FAM91A1
uniprot id: A0A096NWC4
names: Similarity
messages: Belongs to the FAM91 family.

9555:SLA2
gene id: 9555:SLA2
uniprot id: A0A096NUK2
names: Subcellular Location Annotation
messages: Cytoplasm

9555:LOC101003015
gene id: 9555:LOC101003015
uniprot id: A0A096P2Q7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:PKN3
gene id: 9555:PKN3
uniprot id: A0A096P0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

9555:PAPPA
gene id: 9555:PAPPA
uniprot id: A0A096P0R8
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ART1
gene id: 9555:ART1
uniprot id: A0A096N4Y4
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9555:WNT7B
gene id: 9555:WNT7B
uniprot id: A0A8I5MYN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:HPSE
gene id: 9555:HPSE
uniprot id: A0A096MV72
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9555:ODC1
gene id: 9555:ODC1
uniprot id: A0A096NJ00
uniprot id: A0A8I5NKM9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9555:GPKOW
gene id: 9555:GPKOW
uniprot id: A0A096MTM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9555:PACA-F
gene id: 9555:PACA-F
uniprot id: A4GE63
names: Similarity
messages: Belongs to the MHC class I family.

9555:CD151
gene id: 9555:CD151
uniprot id: A0A2I3NAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:TNFSF8
gene id: 9555:TNFSF8
uniprot id: A0A096P0S0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:EXOC2
gene id: 9555:EXOC2
uniprot id: A0A2I3LYN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9555:UMPS
gene id: 9555:UMPS
uniprot id: A0A096N8T5
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9555:KMT2A
gene id: 9555:KMT2A
uniprot id: A0A096N911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
messages: Nucleus

9555:MINDY1
gene id: 9555:MINDY1
uniprot id: A0A096NP94
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9555:ACVR1C
gene id: 9555:ACVR1C
uniprot id: A0A096NCC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9555:CAMLG
gene id: 9555:CAMLG
uniprot id: A0A096MMK2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9555:SLC13A5
gene id: 9555:SLC13A5
uniprot id: A0A2I3NHF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9555:LOC101003939
gene id: 9555:LOC101003939
uniprot id: A0A096NE25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9555:ANKRD13A
gene id: 9555:ANKRD13A
uniprot id: A0A096NC28
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9555:ATG101
gene id: 9555:ATG101
uniprot id: A0A096MSR0
names: Similarity
messages: Belongs to the ATG101 family.

9555:HAT1
gene id: 9555:HAT1
uniprot id: A0A096NZJ1
uniprot id: A0A2I3MSH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9555:DBNL
gene id: 9555:DBNL
uniprot id: A0A096NRM6
uniprot id: A0A2I3LYJ7
uniprot id: A0A2I3NB46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

9555:LGR4
gene id: 9555:LGR4
uniprot id: A0A8I5MUJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:SET
gene id: 9555:SET
uniprot id: A0A2I3MTM8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9555:HADH
gene id: 9555:HADH
uniprot id: A0A096N3L0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9555:SYN1
gene id: 9555:SYN1
uniprot id: A0A096NAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9555:TIMM21
gene id: 9555:TIMM21
uniprot id: A0A8I5QZR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9555:PIK3R1
gene id: 9555:PIK3R1
uniprot id: A0A096MNU6
uniprot id: A0A2I3LE44
uniprot id: A0A2I3LTW1
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9555:SSTR1
gene id: 9555:SSTR1
uniprot id: A0A096MLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:MKNK1
gene id: 9555:MKNK1
uniprot id: A0A096N7T5
uniprot id: A0A2I3M6H3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:TBCE
gene id: 9555:TBCE
uniprot id: A0A096N7W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Cytoplasm

9555:SYVN1
gene id: 9555:SYVN1
uniprot id: A0A096NXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SNRPF
gene id: 9555:SNRPF
uniprot id: A0A096MLH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9555:SLAIN1
gene id: 9555:SLAIN1
uniprot id: A0A096NFD2
uniprot id: A0A2I3LNI3
uniprot id: A0A2I3MC79
uniprot id: A0A2I3NG70
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9555:NOP56
gene id: 9555:NOP56
uniprot id: A0A096NV77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9555:RGS3
gene id: 9555:RGS3
uniprot id: A0A096P0T4
uniprot id: A0A2I3MW58
names: Subcellular Location Annotation
messages: Cytoplasm

9555:NRM
gene id: 9555:NRM
uniprot id: A0A096NLV0
uniprot id: A0A2I3N756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9555:FGFBP3
gene id: 9555:FGFBP3
uniprot id: A0A8I5RA06
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9555:HSF2
gene id: 9555:HSF2
uniprot id: A0A096NZ03
uniprot id: A0A2I3MD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9555:SNX5
gene id: 9555:SNX5
uniprot id: A0A096NVM8
uniprot id: A0A2I3MFB0
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9555:CLCC1
gene id: 9555:CLCC1
uniprot id: A0A096N8G2
uniprot id: A0A2I3LJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9555:RPL35
gene id: 9555:RPL35
uniprot id: A0A096N641
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9555:KBTBD8
gene id: 9555:KBTBD8
uniprot id: A0A096NDA8
uniprot id: A0A2I3LYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9555:CLRN2
gene id: 9555:CLRN2
uniprot id: A0A096NZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9555:L1CAM
gene id: 9555:L1CAM
uniprot id: A9CB47
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9555:NOC3L
gene id: 9555:NOC3L
uniprot id: A0A096P5Q3
uniprot id: A0A8I5NS84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9555:TMA16
gene id: 9555:TMA16
uniprot id: A0A096MR74
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9555:BPGM
gene id: 9555:BPGM
uniprot id: A0A096NFF1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9555:CCNI
gene id: 9555:CCNI
uniprot id: A0A096MVW4
names: Similarity
messages: Belongs to the cyclin family.

9555:SEC22B
gene id: 9555:SEC22B
uniprot id: A0A2I3LPQ1
uniprot id: A0A8I5NMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9555:MLNR
gene id: 9555:MLNR
uniprot id: A0A096N8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:MOB1B
gene id: 9555:MOB1B
uniprot id: A0A2I3LVA5
uniprot id: A0A2I3N2M0
names: Similarity
messages: Belongs to the MOB1/phocein family.

9555:NKX6-1
gene id: 9555:NKX6-1
uniprot id: A0A096NWE0
names: Subcellular Location Annotation
messages: Nucleus

9555:CABP7
gene id: 9555:CABP7
uniprot id: Q866X0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).
messages: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
messages: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
messages: perinuclear region
messages: trans-Golgi network membrane

9555:FAM72A
gene id: 9555:FAM72A
uniprot id: A0A2I3M934
uniprot id: A0A2I3NBI7
names: Similarity
messages: Belongs to the FAM72 family.

9555:NPRL2
gene id: 9555:NPRL2
uniprot id: A0A096N0N9
names: Similarity
messages: Belongs to the NPR2 family.

9555:TMEM201
gene id: 9555:TMEM201
uniprot id: A0A096NQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9555:KRT72
gene id: 9555:KRT72
uniprot id: A0A096MPX0
names: Similarity
messages: Belongs to the intermediate filament family.

9555:EIF6
gene id: 9555:EIF6
uniprot id: A0A096NUQ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9555:KCNQ1
gene id: 9555:KCNQ1
uniprot id: A0A096NDD2
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9555:ZNF496
gene id: 9555:ZNF496
uniprot id: A0A096MNV5
names: Subcellular Location Annotation
messages: Nucleus

9555:ADCK5
gene id: 9555:ADCK5
uniprot id: A0A096ND93
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9555:SH3BGR
gene id: 9555:SH3BGR
uniprot id: A0A8I5P0F4
names: Similarity
messages: Belongs to the SH3BGR family.

9555:WNT10A
gene id: 9555:WNT10A
uniprot id: A0A096NRV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:LOC101019822
gene id: 9555:LOC101019822
uniprot id: A0A096P2Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9555:TRMO
gene id: 9555:TRMO
uniprot id: A0A096P133
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9555:LOC101006121
gene id: 9555:LOC101006121
uniprot id: A0A8I5NZD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9555:F7
gene id: 9555:F7
uniprot id: A9X171
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:ELL
gene id: 9555:ELL
uniprot id: A0A0A0MXK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9555:GPS1
gene id: 9555:GPS1
uniprot id: A0A096NTM2
uniprot id: A0A2I3M117
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN1 family.
messages: Cytoplasm
messages: Nucleus

9555:REM1
gene id: 9555:REM1
uniprot id: A0A096NV11
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9555:ELP2
gene id: 9555:ELP2
uniprot id: A0A096MM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9555:POFUT2
gene id: 9555:POFUT2
uniprot id: A0A096NIA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9555:LOC101000782
gene id: 9555:LOC101000782
uniprot id: A0A2I3M9M7
names: Similarity
messages: Belongs to the CD200R family.

9555:DAD1
gene id: 9555:DAD1
uniprot id: A0A096N5H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9555:EYA2
gene id: 9555:EYA2
uniprot id: A0A096NSD8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9555:AFG1L
gene id: 9555:AFG1L
uniprot id: A0A096NW00
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9555:ILDR2
gene id: 9555:ILDR2
uniprot id: A0A096N4D1
uniprot id: A0A8I5P391
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9555:NRF1
gene id: 9555:NRF1
uniprot id: A0A096NYC1
uniprot id: A0A2I3N2S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9555:SLC13A2
gene id: 9555:SLC13A2
uniprot id: A0A096P394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9555:TMEM9B
gene id: 9555:TMEM9B
uniprot id: A0A2I3MCY5
uniprot id: A0A8I5N894
names: Similarity
messages: Belongs to the TMEM9 family.

9555:MTRF1
gene id: 9555:MTRF1
uniprot id: A0A096MPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9555:SENP2
gene id: 9555:SENP2
uniprot id: A0A2I3N703
names: Similarity
messages: Belongs to the peptidase C48 family.

9555:PPP2R5D
gene id: 9555:PPP2R5D
uniprot id: A0A2I3NBH7
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9555:SLFN11
gene id: 9555:SLFN11
uniprot id: A0A1L3HEG3
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9555:KCNJ8
gene id: 9555:KCNJ8
uniprot id: A0A8I5NFH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9555:ZNF687
gene id: 9555:ZNF687
uniprot id: A0A2I3N352
uniprot id: A0A8J8YKM2
uniprot id: A9X199
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:SOGA1
gene id: 9555:SOGA1
uniprot id: A0A096NX06
names: Similarity
messages: Belongs to the SOGA family.

9555:TRPC4
gene id: 9555:TRPC4
uniprot id: A0A2I3LZR5
names: Subcellular Location Annotation
messages: Membrane

9555:PPP4C
gene id: 9555:PPP4C
uniprot id: A0A8I5NIV5
names: Similarity
messages: Belongs to the PPP phosphatase family.

9555:KHDC3L
gene id: 9555:KHDC3L
uniprot id: A9X184
names: Similarity
messages: Belongs to the KHDC1 family.

9555:RNF10
gene id: 9555:RNF10
uniprot id: A0A096N564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9555:HKDC1
gene id: 9555:HKDC1
uniprot id: A0A096P4Z5
names: Similarity
messages: Belongs to the hexokinase family.

9555:CDK5R2
gene id: 9555:CDK5R2
uniprot id: A0A096N9X6
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9555:VHL
gene id: 9555:VHL
uniprot id: A0A2I3LVU4
uniprot id: A0A2I3MW02
names: Similarity
messages: Belongs to the VHL family.

9555:TLX3
gene id: 9555:TLX3
uniprot id: A0A096NCH0
names: Subcellular Location Annotation
messages: Nucleus

9555:SYT17
gene id: 9555:SYT17
uniprot id: A0A096MWV5
uniprot id: A0A096NQJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9555:GUCA2A
gene id: 9555:GUCA2A
uniprot id: A0A096NYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9555:SMARCA1
gene id: 9555:SMARCA1
uniprot id: A0A096MU89
uniprot id: A0A2I3MUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9555:AHCYL2
gene id: 9555:AHCYL2
uniprot id: A0A2I3M8L0
uniprot id: A0A2I3N853
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9555:TNFRSF19
gene id: 9555:TNFRSF19
uniprot id: A0A096N9Q0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NT5C2
gene id: 9555:NT5C2
uniprot id: A0A096P6G6
uniprot id: A0A2I3M8B9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9555:LCAT
gene id: 9555:LCAT
uniprot id: Q08758
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: APOA1 is the most potent activator in plasma. Also activated by APOE, APOC1 and APOA4 (By similarity).
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).
messages: Most abundant in liver and cerebellum.
messages: Secreted

9555:NUCB2
gene id: 9555:NUCB2
uniprot id: A0A096N756
names: Similarity
messages: Belongs to the nucleobindin family.

9555:CCNH
gene id: 9555:CCNH
uniprot id: A0A096MN34
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9555:VIRMA
gene id: 9555:VIRMA
uniprot id: A0A096NDW4
names: Similarity
messages: Belongs to the vir family.

9555:TRAPPC2
gene id: 9555:TRAPPC2
uniprot id: A0A8I5NF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9555:TAS2R8
gene id: 9555:TAS2R8
uniprot id: A0A8I5NI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9555:EPN2
gene id: 9555:EPN2
uniprot id: A0A096P342
uniprot id: A0A2I3LFW3
names: Similarity
messages: Belongs to the epsin family.

9555:KIF1C
gene id: 9555:KIF1C
uniprot id: A0A096P2J3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:GABRA5
gene id: 9555:GABRA5
uniprot id: A0A096NSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:PFDN5
gene id: 9555:PFDN5
uniprot id: A0A096N1G6
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9555:MPP1
gene id: 9555:MPP1
uniprot id: A9CB74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
messages: Heterodimer with PALS1. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain) (By similarity).
messages: Palmitoylated.
messages: stereocilium

9555:EIF4G1
gene id: 9555:EIF4G1
uniprot id: A0A096NQ43
uniprot id: A0A2I3LXF0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9555:LHFPL4
gene id: 9555:LHFPL4
uniprot id: A0A2I3N6B9
names: Subcellular Location Annotation
messages: Membrane

9555:EIF3I
gene id: 9555:EIF3I
uniprot id: A0A096NFN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9555:PLSCR4
gene id: 9555:PLSCR4
uniprot id: A0A096P027
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9555:ELK4
gene id: 9555:ELK4
uniprot id: A0A096MT07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:SLC39A5
gene id: 9555:SLC39A5
uniprot id: A0A096MPW9
names: Subcellular Location Annotation
messages: Membrane

9555:NFYB
gene id: 9555:NFYB
uniprot id: A0A096ND24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9555:FEN1
gene id: 9555:FEN1
uniprot id: A0A096NYK4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9555:HEXIM1
gene id: 9555:HEXIM1
uniprot id: A0A096NCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9555:LOC101025927
gene id: 9555:LOC101025927
uniprot id: A0A096NFW6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9555:SNRPN
gene id: 9555:SNRPN
uniprot id: A0A096NSW9
uniprot id: A0A2I3MWW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9555:LIG3
gene id: 9555:LIG3
uniprot id: A0A096P3V0
uniprot id: A0A2I3MRZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9555:BID
gene id: 9555:BID
uniprot id: A0A096NVY7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:BEST1
gene id: 9555:BEST1
uniprot id: A0A096NB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9555:LIAS
gene id: 9555:LIAS
uniprot id: A0A096NNZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9555:ENPP4
gene id: 9555:ENPP4
uniprot id: A0A096NIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9555:DNMT3B
gene id: 9555:DNMT3B
uniprot id: A0A2I3MAR2
uniprot id: A0A2I3MEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9555:TNP2
gene id: 9555:TNP2
uniprot id: A0A096NLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

9555:SLC27A1
gene id: 9555:SLC27A1
uniprot id: A0A0A0MWH3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9555:DLL4
gene id: 9555:DLL4
uniprot id: A0A096NTJ5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9555:POLR1A
gene id: 9555:POLR1A
uniprot id: A0A096NZX0
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9555:HABP2
gene id: 9555:HABP2
uniprot id: A0A096N5I4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GBX2
gene id: 9555:GBX2
uniprot id: A0A096N887
names: Subcellular Location Annotation
messages: Nucleus

9555:MTERF4
gene id: 9555:MTERF4
uniprot id: A0A096NFK9
names: Similarity
messages: Belongs to the mTERF family.

9555:KIF5A
gene id: 9555:KIF5A
uniprot id: A0A2I3ML31
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:RRP15
gene id: 9555:RRP15
uniprot id: A0A096N7V4
names: Similarity
messages: Belongs to the RRP15 family.

9555:HENMT1
gene id: 9555:HENMT1
uniprot id: A0A096NPN5
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9555:AADACL3
gene id: 9555:AADACL3
uniprot id: A0A096NDF3
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9555:RAB39A
gene id: 9555:RAB39A
uniprot id: A0A8I5R5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9555:LOC101013544
gene id: 9555:LOC101013544
uniprot id: A0A8I5NJA6
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9555:IP6K3
gene id: 9555:IP6K3
uniprot id: A0A8I5NG88
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:CDKN3
gene id: 9555:CDKN3
uniprot id: A0A096NV50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9555:RPS29
gene id: 9555:RPS29
uniprot id: A0A096NE90
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9555:L3MBTL3
gene id: 9555:L3MBTL3
uniprot id: A0A096P072
uniprot id: A0A2I3MKF6
names: Subcellular Location Annotation
messages: Nucleus

9555:TMED9
gene id: 9555:TMED9
uniprot id: A0A8I5N749
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:ADAMTS15
gene id: 9555:ADAMTS15
uniprot id: A0A096NEU0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:CDC20B
gene id: 9555:CDC20B
uniprot id: A0A096NC04
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9555:ABCD3
gene id: 9555:ABCD3
uniprot id: A0A096NPC4
uniprot id: A0A8I5NEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9555:DDX41
gene id: 9555:DDX41
uniprot id: A0A096NDQ9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9555:THRAP3
gene id: 9555:THRAP3
uniprot id: A0A096MV19
uniprot id: A0A8I5NAV3
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9555:FGF13
gene id: 9555:FGF13
uniprot id: A0A096N1F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9555:TK1
gene id: 9555:TK1
uniprot id: A0A096NT67
names: Similarity
messages: Belongs to the thymidine kinase family.

9555:C8H8orf37
gene id: 9555:C8H8orf37
uniprot id: A0A096NEP7
uniprot id: A0A8I5NK56
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9555:CPT2
gene id: 9555:CPT2
uniprot id: A0A096NY67
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9555:GNPDA1
gene id: 9555:GNPDA1
uniprot id: A0A096N652
uniprot id: A0A2I3LRF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9555:SEMA4C
gene id: 9555:SEMA4C
uniprot id: A0A096NGT0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ZFP36L1
gene id: 9555:ZFP36L1
uniprot id: A0A096NVR1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9555:GRM8
gene id: 9555:GRM8
uniprot id: A0A8J8YFC2
uniprot id: A9RA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9555:LANCL1
gene id: 9555:LANCL1
uniprot id: A0A096MVE3
names: Similarity
messages: Belongs to the LanC-like protein family.

9555:ABI3
gene id: 9555:ABI3
uniprot id: A0A8I5R1X8
names: Similarity
messages: Belongs to the ABI family.

9555:LOC100997097
gene id: 9555:LOC100997097
uniprot id: A0A096NJ60
uniprot id: A0A2I3NEK1
names: Subcellular Location Annotation
messages: Membrane

9555:DNASE1L2
gene id: 9555:DNASE1L2
uniprot id: A0A096NL30
names: Similarity
messages: Belongs to the DNase I family.

9555:HBE1
gene id: 9555:HBE1
uniprot id: A9L8Y1
names: Similarity
messages: Belongs to the globin family.

9555:SDHB
gene id: 9555:SDHB
uniprot id: A0A096MXT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9555:LOC101010375
gene id: 9555:LOC101010375
uniprot id: A0A2I3NDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9555:TM6SF1
gene id: 9555:TM6SF1
uniprot id: A0A096NN04
uniprot id: A0A2I3MUU5
names: Subcellular Location Annotation
messages: Membrane

9555:SCNN1B
gene id: 9555:SCNN1B
uniprot id: A0A096NHE0
names: Subcellular Location Annotation
messages: Membrane

9555:COPS6
gene id: 9555:COPS6
uniprot id: A0A096N153
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9555:IDH2
gene id: 9555:IDH2
uniprot id: A0A096NN95
uniprot id: A0A2I3NGT7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9555:REXO4
gene id: 9555:REXO4
uniprot id: A0A096NRP1
names: Similarity
messages: Belongs to the REXO4 family.

9555:LFNG
gene id: 9555:LFNG
uniprot id: A0A2I3MIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:GRWD1
gene id: 9555:GRWD1
uniprot id: A0A0A0MW66
names: Subcellular Location Annotation
messages: Nucleus

9555:CDH5
gene id: 9555:CDH5
uniprot id: A0A096NJ54
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9555:NUBP1
gene id: 9555:NUBP1
uniprot id: A0A096NLN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9555:POLR2D
gene id: 9555:POLR2D
uniprot id: A0A096NRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9555:RBPJ
gene id: 9555:RBPJ
uniprot id: A0A096NZL3
uniprot id: A0A2I3MNT7
uniprot id: A0A2I3N1M1
uniprot id: A0A8I5NU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9555:APEX2
gene id: 9555:APEX2
uniprot id: A0A096N3Q5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9555:PLA2G10
gene id: 9555:PLA2G10
uniprot id: A0A096NLT5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9555:AMACR
gene id: 9555:AMACR
uniprot id: A7XAJ9
names: Similarity
messages: Belongs to the CoA-transferase III family.

9555:URAD
gene id: 9555:URAD
uniprot id: A0A096NYF5
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9555:BTN1A1
gene id: 9555:BTN1A1
uniprot id: A0A096NLH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9555:GALNT3
gene id: 9555:GALNT3
uniprot id: A0A096N3U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:TNFSF11
gene id: 9555:TNFSF11
uniprot id: A0A2I3LEX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9555:EIF5A
gene id: 9555:EIF5A
uniprot id: A0A096P2N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:PREB
gene id: 9555:PREB
uniprot id: A0A2I3LWL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9555:PLK3
gene id: 9555:PLK3
uniprot id: A0A2I3MXI7
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9555:LOC101016723
gene id: 9555:LOC101016723
uniprot id: A0A096MSC7
uniprot id: A0A2I3MK50
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:SCN7A
gene id: 9555:SCN7A
uniprot id: A0A2I3LH88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9555:FOXP2
gene id: 9555:FOXP2
uniprot id: A0A096NFI9
uniprot id: A9RAA3
names: Subcellular Location Annotation
messages: Nucleus

9555:GTF2A1
gene id: 9555:GTF2A1
uniprot id: A0A096NRB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9555:ZDHHC8
gene id: 9555:ZDHHC8
uniprot id: A0A096NQA9
uniprot id: A0A2I3LXQ9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:GDF9
gene id: 9555:GDF9
uniprot id: A9CB18
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).
messages: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.
messages: Phosphorylated; phosphorylation is critical for GDF9 function.
messages: Required for ovarian folliculogenesis.
messages: Secreted

9555:MMP12
gene id: 9555:MMP12
uniprot id: A0A096NXM4
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:WDYHV1
gene id: 9555:WDYHV1
uniprot id: A0A096N103
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9555:RBBP7
gene id: 9555:RBBP7
uniprot id: A0A096MKM8
uniprot id: A0A2I3LNX3
uniprot id: A0A2I3M719
names: Subcellular Location Annotation
messages: Nucleus

9555:SIVA1
gene id: 9555:SIVA1
uniprot id: A0A096NK31
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9555:RHO
gene id: 9555:RHO
uniprot id: A0A096NPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9555:LPIN1
gene id: 9555:LPIN1
uniprot id: A0A2I3LW65
uniprot id: A0A2I3N356
names: Similarity
messages: Belongs to the lipin family.

9555:NME9
gene id: 9555:NME9
uniprot id: A0A096NS21
names: Similarity
messages: Belongs to the NDK family.

9555:GNG11
gene id: 9555:GNG11
uniprot id: A0A8I5NW67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9555:TMEM186
gene id: 9555:TMEM186
uniprot id: A0A096NLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9555:MGAT4D
gene id: 9555:MGAT4D
uniprot id: A0A096MUH6
uniprot id: A0A2I3MVZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:NMNAT1
gene id: 9555:NMNAT1
uniprot id: A0A2I3MIF6
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9555:ZDHHC4
gene id: 9555:ZDHHC4
uniprot id: A0A096N158
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:DAO
gene id: 9555:DAO
uniprot id: A0A096NQF0
uniprot id: A0A2I3M6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9555:BHLHB9
gene id: 9555:BHLHB9
uniprot id: A0A096NW89
names: Similarity
messages: Belongs to the GPRASP family.

9555:PGR
gene id: 9555:PGR
uniprot id: A7X8C7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B (By similarity).
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294 (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
messages: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294 (By similarity).

9555:ZKSCAN2
gene id: 9555:ZKSCAN2
uniprot id: A0A096NHI0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:FAR1
gene id: 9555:FAR1
uniprot id: A0A096MZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9555:ODF2L
gene id: 9555:ODF2L
uniprot id: A0A8I5N9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9555:NDUFC1
gene id: 9555:NDUFC1
uniprot id: A0A096MLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:TPI1
gene id: 9555:TPI1
uniprot id: A0A096NGJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9555:HSPB8
gene id: 9555:HSPB8
uniprot id: A0A096N1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9555:STIM2
gene id: 9555:STIM2
uniprot id: A0A096NZL6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:OGG1
gene id: 9555:OGG1
uniprot id: A0A096NQ19
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9555:PPP2CB
gene id: 9555:PPP2CB
uniprot id: A0A096MUB1
uniprot id: A0A096N3J6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9555:RAD54L2
gene id: 9555:RAD54L2
uniprot id: A0A096NYI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9555:CHRNB2
gene id: 9555:CHRNB2
uniprot id: A0A096MXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9555:RPS26
gene id: 9555:RPS26
uniprot id: A0A2I3MBA7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9555:AURKB
gene id: 9555:AURKB
uniprot id: A0A2I3MT06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9555:KRT19
gene id: 9555:KRT19
uniprot id: A0A2I3MA29
names: Similarity
messages: Belongs to the intermediate filament family.

9555:THPO
gene id: 9555:THPO
uniprot id: A0A096N8Z5
uniprot id: A0A2I3MX71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9555:HNRNPUL2
gene id: 9555:HNRNPUL2
uniprot id: A0A096N032
names: Subcellular Location Annotation
messages: Nucleus

9555:TRIM36
gene id: 9555:TRIM36
uniprot id: A0A096MN33
uniprot id: A0A096N907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9555:CARNMT1
gene id: 9555:CARNMT1
uniprot id: A0A096P1T1
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9555:SF3B5
gene id: 9555:SF3B5
uniprot id: A0A2I3LT66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9555:ELOVL4
gene id: 9555:ELOVL4
uniprot id: A0A096NQ85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9555:B3GAT3
gene id: 9555:B3GAT3
uniprot id: A0A096MKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:TAF1D
gene id: 9555:TAF1D
uniprot id: A0A096N9Z7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9555:POLL
gene id: 9555:POLL
uniprot id: A0A2I3MZX5
uniprot id: E5FGJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9555:TREX2
gene id: 9555:TREX2
uniprot id: A0A096N6A8
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9555:DRD1
gene id: 9555:DRD1
uniprot id: A0A096MZY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9555:B4GALT3
gene id: 9555:B4GALT3
uniprot id: A0A096NCZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9555:SMO
gene id: 9555:SMO
uniprot id: A0A096NUB7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:SCN1B
gene id: 9555:SCN1B
uniprot id: A0A0A0MX70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9555:GATA3
gene id: 9555:GATA3
uniprot id: A0A096P3E2
names: Subcellular Location Annotation
messages: Nucleus

9555:SLC5A1
gene id: 9555:SLC5A1
uniprot id: A0A096NJN9
uniprot id: A9CB39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9555:AZIN2
gene id: 9555:AZIN2
uniprot id: A0A096N719
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9555:NKD2
gene id: 9555:NKD2
uniprot id: A0A096MW93
uniprot id: A0A096MWN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:MAEL
gene id: 9555:MAEL
uniprot id: A0A096NBP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9555:PUS7L
gene id: 9555:PUS7L
uniprot id: A0A096N4R8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9555:OR52B6
gene id: 9555:OR52B6
uniprot id: A9L8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:CCL16
gene id: 9555:CCL16
uniprot id: A0A096P3Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:GCSH
gene id: 9555:GCSH
uniprot id: A0A096MV31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9555:UBE2L5
gene id: 9555:UBE2L5
uniprot id: A9RA83
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:EXO5
gene id: 9555:EXO5
uniprot id: A0A2I3LZG9
names: Similarity
messages: Belongs to the EXO5 family.

9555:GPHA2
gene id: 9555:GPHA2
uniprot id: B0CM72
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101022919
gene id: 9555:LOC101022919
uniprot id: A0A8I5R8F3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9555:CNOT10
gene id: 9555:CNOT10
uniprot id: A0A096NQB5
uniprot id: A0A2I3LYP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9555:RENBP
gene id: 9555:RENBP
uniprot id: A0A096ML31
uniprot id: A9CB51
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9555:RAB27B
gene id: 9555:RAB27B
uniprot id: A0A096N186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9555:POLM
gene id: 9555:POLM
uniprot id: A0A096NAR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9555:RUNX3
gene id: 9555:RUNX3
uniprot id: A0A096NWX7
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9555:TMED10
gene id: 9555:TMED10
uniprot id: A0A096NS51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:CAPN2
gene id: 9555:CAPN2
uniprot id: A0A8I5NH07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:UBLCP1
gene id: 9555:UBLCP1
uniprot id: A0A8I5NN04
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9555:GOLPH3
gene id: 9555:GOLPH3
uniprot id: A0A2I3LCX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9555:ATP8B1
gene id: 9555:ATP8B1
uniprot id: A0A096N185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9555:TM4SF18
gene id: 9555:TM4SF18
uniprot id: A0A096N3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9555:LOC103877723
gene id: 9555:LOC103877723
uniprot id: B6CZ49
names: Subcellular Location Annotation
messages: Cytoplasm

9555:BUD31
gene id: 9555:BUD31
uniprot id: A0A096N3M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9555:PWP2
gene id: 9555:PWP2
uniprot id: A0A096NII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9555:BIRC2
gene id: 9555:BIRC2
uniprot id: A0A096MN99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9555:CDADC1
gene id: 9555:CDADC1
uniprot id: A0A096NF63
uniprot id: A0A2I3LY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

9555:TMEM116
gene id: 9555:TMEM116
uniprot id: A0A096MU67
uniprot id: A0A2I3M906
names: Subcellular Location Annotation
messages: Membrane

9555:GLIPR1
gene id: 9555:GLIPR1
uniprot id: A0A096N7H3
names: Similarity
messages: Belongs to the CRISP family.

9555:LOC101022646
gene id: 9555:LOC101022646
uniprot id: A0A096MKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:APOC4
gene id: 9555:APOC4
uniprot id: A0A096P2H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9555:TNFAIP2
gene id: 9555:TNFAIP2
uniprot id: A0A096NJX5
names: Similarity
messages: Belongs to the SEC6 family.

9555:TRUB2
gene id: 9555:TRUB2
uniprot id: A0A096P0L4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9555:ALDH3A2
gene id: 9555:ALDH3A2
uniprot id: A0A096P349
uniprot id: A0A2I3MS78
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:MAGOH
gene id: 9555:MAGOH
uniprot id: A0A2I3MAT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9555:DDB2
gene id: 9555:DDB2
uniprot id: A0A096N3C6
uniprot id: A0A2I3NC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9555:TERF2IP
gene id: 9555:TERF2IP
uniprot id: A0A096N3N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9555:LOC101020977
gene id: 9555:LOC101020977
uniprot id: A0A2I3NH53
names: Similarity
messages: Belongs to the histone H3 family.

9555:BAIAP2
gene id: 9555:BAIAP2
uniprot id: A0A2I3MBC3
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9555:SLC6A3
gene id: 9555:SLC6A3
uniprot id: A0A096MN61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

9555:D2HGDH
gene id: 9555:D2HGDH
uniprot id: A0A096N2N2
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9555:AK2
gene id: 9555:AK2
uniprot id: A0A2I3LVZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9555:HSD17B11
gene id: 9555:HSD17B11
uniprot id: A0A096NDG2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:BCL7B
gene id: 9555:BCL7B
uniprot id: A0A096NQD2
names: Similarity
messages: Belongs to the BCL7 family.

9555:PPIC
gene id: 9555:PPIC
uniprot id: A0A096N4P2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:TRIM2
gene id: 9555:TRIM2
uniprot id: A0A2I3N4T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9555:TSHB
gene id: 9555:TSHB
uniprot id: A0A096NYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9555:CDC42BPG
gene id: 9555:CDC42BPG
uniprot id: B0CM68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9555:HSPA4L
gene id: 9555:HSPA4L
uniprot id: A0A096NPS1
uniprot id: A0A2I3LGI3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9555:ARF5
gene id: 9555:ARF5
uniprot id: A9RA79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9555:GIMD1
gene id: 9555:GIMD1
uniprot id: A0A8I5NBR3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9555:P2RY13
gene id: 9555:P2RY13
uniprot id: A0A096MY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:HPSE2
gene id: 9555:HPSE2
uniprot id: A0A2I3LF58
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9555:PTPN2
gene id: 9555:PTPN2
uniprot id: A0A2I3NE51
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9555:EIF5A2
gene id: 9555:EIF5A2
uniprot id: A0A2I3MV74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9555:OVGP1
gene id: 9555:OVGP1
uniprot id: P36718
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the time of ovulation.
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
messages: Oviduct.
messages: secretory vesicle

9555:NSMCE1
gene id: 9555:NSMCE1
uniprot id: A0A096NHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9555:VEPH1
gene id: 9555:VEPH1
uniprot id: A0A096MZN2
names: Similarity
messages: Belongs to the MELT/VEPH family.

9555:DUSP6
gene id: 9555:DUSP6
uniprot id: A0A8I5N5Q9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:ATXN1L
gene id: 9555:ATXN1L
uniprot id: A0A096NEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9555:SH3RF3
gene id: 9555:SH3RF3
uniprot id: A0A096NUD1
names: Similarity
messages: Belongs to the SH3RF family.

9555:FAM228A
gene id: 9555:FAM228A
uniprot id: A0A2I3M1I5
names: Similarity
messages: Belongs to the FAM228 family.

9555:NRP2
gene id: 9555:NRP2
uniprot id: A0A2I3LTT8
uniprot id: A0A2I3M6A7
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CTDP1
gene id: 9555:CTDP1
uniprot id: A0A096MS85
uniprot id: A0A096MTT4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9555:ING3
gene id: 9555:ING3
uniprot id: A0A096MVW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9555:ITGA2B
gene id: 9555:ITGA2B
uniprot id: A0A096P628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9555:PPRC1
gene id: 9555:PPRC1
uniprot id: A0A096P6D4
uniprot id: A0A2I3MBV6
names: Subcellular Location Annotation
messages: Nucleus

9555:TBL1XR1
gene id: 9555:TBL1XR1
uniprot id: A0A096NXK0
names: Similarity
messages: Belongs to the WD repeat EBI family.

9555:DDX54
gene id: 9555:DDX54
uniprot id: A0A096NQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9555:AKAP4
gene id: 9555:AKAP4
uniprot id: A0A2I3LRN7
names: Similarity
messages: Belongs to the AKAP110 family.

9555:EVA1C
gene id: 9555:EVA1C
uniprot id: A9CAY7
names: Similarity
messages: Belongs to the EVA1 family.

9555:THBS3
gene id: 9555:THBS3
uniprot id: A0A096N055
uniprot id: A0A2I3LKD5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:BMP4
gene id: 9555:BMP4
uniprot id: B0CM38
names: Similarity
messages: Belongs to the TGF-beta family.

9555:LOC101018035
gene id: 9555:LOC101018035
uniprot id: A0A2I3LTH8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9555:SRRT
gene id: 9555:SRRT
uniprot id: A0A096NGW3
names: Similarity
messages: Belongs to the ARS2 family.

9555:RPS6KB2
gene id: 9555:RPS6KB2
uniprot id: A0A096N655
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:SERPINA12
gene id: 9555:SERPINA12
uniprot id: A0A096NJJ6
names: Similarity
messages: Belongs to the serpin family.

9555:NTSR1
gene id: 9555:NTSR1
uniprot id: A0A096NNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TMEM38B
gene id: 9555:TMEM38B
uniprot id: A0A096P0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9555:DNAJA2
gene id: 9555:DNAJA2
uniprot id: A0A096NI29
names: Subcellular Location Annotation
messages: Membrane

9555:CA5A
gene id: 9555:CA5A
uniprot id: A0A096N1V1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9555:SYCE1L
gene id: 9555:SYCE1L
uniprot id: A0A096MNE9
names: Similarity
messages: Belongs to the SYCE family.

9555:HNRNPD
gene id: 9555:HNRNPD
uniprot id: A0A096NF21
uniprot id: A0A096NXS2
uniprot id: A0A2I3N200
uniprot id: A0A8I5NM32
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:ENTPD7
gene id: 9555:ENTPD7
uniprot id: A0A2I3LXS3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9555:SLC34A1
gene id: 9555:SLC34A1
uniprot id: A0A096MNC0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9555:YPEL2
gene id: 9555:YPEL2
uniprot id: A0A096P4W6
names: Similarity
messages: Belongs to the yippee family.

9555:IER2
gene id: 9555:IER2
uniprot id: A0A0A0MUT2
names: Similarity
messages: Belongs to the IER family.

9555:KIF11
gene id: 9555:KIF11
uniprot id: A0A096P5L9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:CDK8
gene id: 9555:CDK8
uniprot id: A0A2I3MHU0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:RPL36
gene id: 9555:RPL36
uniprot id: A0A2I3LML8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9555:GPR39
gene id: 9555:GPR39
uniprot id: A0A096MRD5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:ENTPD5
gene id: 9555:ENTPD5
uniprot id: A0A096N5G9
uniprot id: A0A2I3MSI4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9555:DLX2
gene id: 9555:DLX2
uniprot id: A0A096NZJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9555:SUV39H1
gene id: 9555:SUV39H1
uniprot id: A0A096N1M7
uniprot id: A0A2I3LCB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9555:BRINP3
gene id: 9555:BRINP3
uniprot id: A0A096NAE1
names: Similarity
messages: Belongs to the BRINP family.

9555:TMEM39B
gene id: 9555:TMEM39B
uniprot id: A0A096MSN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9555:CRABP2
gene id: 9555:CRABP2
uniprot id: A0A096N409
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:PAQR3
gene id: 9555:PAQR3
uniprot id: A0A096N803
uniprot id: A0A2I3NDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9555:PRKAR1A
gene id: 9555:PRKAR1A
uniprot id: A0A096NU08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9555:GPR18
gene id: 9555:GPR18
uniprot id: A0A096NBW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9555:JAKMIP2
gene id: 9555:JAKMIP2
uniprot id: A0A096N194
uniprot id: A0A2I3LS90
uniprot id: A0A2I3N4I5
uniprot id: A0A2I3NIN0
uniprot id: A0A8I5N6A2
names: Similarity
messages: Belongs to the JAKMIP family.

9555:MAN1A1
gene id: 9555:MAN1A1
uniprot id: A0A096NCE2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9555:KRT13
gene id: 9555:KRT13
uniprot id: A0A096P5M7
uniprot id: A0A2I3MTG1
names: Similarity
messages: Belongs to the intermediate filament family.

9555:KCTD19
gene id: 9555:KCTD19
uniprot id: A0A2I3NH18
names: Subcellular Location Annotation
messages: Cell membrane

9555:TRAF6
gene id: 9555:TRAF6
uniprot id: A0A096MX12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9555:NXF1
gene id: 9555:NXF1
uniprot id: A0A096NET5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9555:LOC101021735
gene id: 9555:LOC101021735
uniprot id: A0A2I3MHN9
uniprot id: A0A2I3MLC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:MRPL12
gene id: 9555:MRPL12
uniprot id: A0A096NTH9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9555:RPL37
gene id: 9555:RPL37
uniprot id: A0A2I3N5I0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9555:INPP1
gene id: 9555:INPP1
uniprot id: A0A096NMQ4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9555:TSPAN4
gene id: 9555:TSPAN4
uniprot id: A0A096NYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:RAB3D
gene id: 9555:RAB3D
uniprot id: A0A2I3MXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9555:ITIH6
gene id: 9555:ITIH6
uniprot id: A0A096MRV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9555:VTI1A
gene id: 9555:VTI1A
uniprot id: A0A2I3LDN3
uniprot id: A0A2I3LJT0
uniprot id: A0A8I5NI15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9555:TBX6
gene id: 9555:TBX6
uniprot id: A0A096NHQ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:LOC101003204
gene id: 9555:LOC101003204
uniprot id: A0A096MPY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:PPA1
gene id: 9555:PPA1
uniprot id: A0A8I5NK25
names: Similarity
messages: Belongs to the PPase family.

9555:TSC22D3
gene id: 9555:TSC22D3
uniprot id: A0A096MTF0
uniprot id: A0A2I3MBT1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9555:CCDC85A
gene id: 9555:CCDC85A
uniprot id: A0A096N806
uniprot id: A0A2I3MED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9555:UGT1A7
gene id: 9555:UGT1A7
uniprot id: Q20CL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:CAPZA3
gene id: 9555:CAPZA3
uniprot id: A0A096MNB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9555:DOLK
gene id: 9555:DOLK
uniprot id: B0CM92
names: Similarity
messages: Belongs to the polyprenol kinase family.

9555:MCOLN3
gene id: 9555:MCOLN3
uniprot id: A0A2I3NCW1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9555:CAMK1
gene id: 9555:CAMK1
uniprot id: A0A096MM11
uniprot id: A0A8I5R6A0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:APEX1
gene id: 9555:APEX1
uniprot id: A0A096NNL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9555:SULT1E1
gene id: 9555:SULT1E1
uniprot id: A0A096NSK0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9555:SCAP
gene id: 9555:SCAP
uniprot id: A0A096NCR5
uniprot id: A0A2I3LM27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9555:USP45
gene id: 9555:USP45
uniprot id: A0A096NUH6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9555:MRPL35
gene id: 9555:MRPL35
uniprot id: A0A096NZY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9555:RARS1
gene id: 9555:RARS1
uniprot id: A0A096MLR0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9555:SNAP23
gene id: 9555:SNAP23
uniprot id: A0A096P0C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9555:PARP14
gene id: 9555:PARP14
uniprot id: A0A096MZ42
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:DPM1
gene id: 9555:DPM1
uniprot id: A0A2I3M5U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9555:IGF2
gene id: 9555:IGF2
uniprot id: A9L955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9555:SOD1
gene id: 9555:SOD1
uniprot id: A0A096NQK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9555:GALC
gene id: 9555:GALC
uniprot id: A0A096NRB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

9555:FDXR
gene id: 9555:FDXR
uniprot id: A0A096NSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

9555:FAM167B
gene id: 9555:FAM167B
uniprot id: A0A096MWT0
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9555:PCYT1B
gene id: 9555:PCYT1B
uniprot id: A0A096N6P2
uniprot id: A0A2I3NDN3
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9555:BLCAP
gene id: 9555:BLCAP
uniprot id: A0A096MQ82
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9555:PREP
gene id: 9555:PREP
uniprot id: A0A096NAZ8
names: Similarity
messages: Belongs to the peptidase S9A family.

9555:NAP1L4
gene id: 9555:NAP1L4
uniprot id: A0A2I3LTG0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9555:GABRR2
gene id: 9555:GABRR2
uniprot id: A0A2I3M9K4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:TMEM65
gene id: 9555:TMEM65
uniprot id: A0A096N0D0
uniprot id: A0A8I5N2N3
names: Subcellular Location Annotation
messages: Membrane

9555:RAB14
gene id: 9555:RAB14
uniprot id: A0A096P0P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9555:ASB12
gene id: 9555:ASB12
uniprot id: A0A096N9W0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:NCF2
gene id: 9555:NCF2
uniprot id: A0A2I3NHU8
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9555:CCR1
gene id: 9555:CCR1
uniprot id: A0A8I5N3W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:L3HYPDH
gene id: 9555:L3HYPDH
uniprot id: A0A096NVE9
uniprot id: A0A8I5N5V6
uniprot id: A0A8I5R5D9
names: Similarity
messages: Belongs to the proline racemase family.

9555:GLB1L3
gene id: 9555:GLB1L3
uniprot id: A0A096N0U7
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9555:CEBPD
gene id: 9555:CEBPD
uniprot id: A0A096NFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9555:SEMG2
gene id: 9555:SEMG2
uniprot id: A4K2M9
names: Similarity
messages: Belongs to the semenogelin family.

9555:ESYT1
gene id: 9555:ESYT1
uniprot id: A0A096MQX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SLC7A6
gene id: 9555:SLC7A6
uniprot id: A0A096NFR2
names: Subcellular Location Annotation
messages: Membrane

9555:LDB3
gene id: 9555:LDB3
uniprot id: A0A2I3MU89
uniprot id: A0A2I3N5B5
names: Subcellular Location Annotation
messages: Z line

9555:CDH9
gene id: 9555:CDH9
uniprot id: A0A096MML6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:KRT33B
gene id: 9555:KRT33B
uniprot id: A0A096P5L5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:PLK2
gene id: 9555:PLK2
uniprot id: A0A096NBN2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9555:NOSIP
gene id: 9555:NOSIP
uniprot id: A0A0A0MVU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9555:SRP9
gene id: 9555:SRP9
uniprot id: A0A8I5NJY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9555:PDE1A
gene id: 9555:PDE1A
uniprot id: A0A096N0G4
uniprot id: A0A2I3LHR2
uniprot id: A0A2I3MR77
uniprot id: A0A2I3N850
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:PPP1R1B
gene id: 9555:PPP1R1B
uniprot id: A0A096P5C0
uniprot id: A0A2I3MZ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9555:SLC23A2
gene id: 9555:SLC23A2
uniprot id: A0A096NVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9555:SPNS2
gene id: 9555:SPNS2
uniprot id: A0A096P2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9555:RPS18
gene id: 9555:RPS18
uniprot id: A0A2I3MGM0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9555:H1-3
gene id: 9555:H1-3
uniprot id: A0A8I5NA22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9555:DIS3L
gene id: 9555:DIS3L
uniprot id: A0A096NME7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

9555:GALNT6
gene id: 9555:GALNT6
uniprot id: A0A096N9P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:CHMP3
gene id: 9555:CHMP3
uniprot id: A0A096NPG9
names: Similarity
messages: Belongs to the SNF7 family.

9555:LOC100997559
gene id: 9555:LOC100997559
uniprot id: A0A2I3M964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:RPS7
gene id: 9555:RPS7
uniprot id: A0A096N4U1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9555:HBEGF
gene id: 9555:HBEGF
uniprot id: A0A096N0E6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TALDO1
gene id: 9555:TALDO1
uniprot id: A0A096N709
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9555:TPST2
gene id: 9555:TPST2
uniprot id: A0A096NRG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9555:CELF3
gene id: 9555:CELF3
uniprot id: A9X1A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9555:VPS4A
gene id: 9555:VPS4A
uniprot id: A0A096NZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:HOMEZ
gene id: 9555:HOMEZ
uniprot id: A0A096MSW0
names: Subcellular Location Annotation
messages: Nucleus

9555:ELOVL2
gene id: 9555:ELOVL2
uniprot id: A0A096NKX3
uniprot id: A0A8I5N7Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9555:ST3GAL3
gene id: 9555:ST3GAL3
uniprot id: A0A096N7D9
uniprot id: A0A2I3LPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:KRT4
gene id: 9555:KRT4
uniprot id: A0A096MVH8
names: Similarity
messages: Belongs to the intermediate filament family.

9555:BTF3L4
gene id: 9555:BTF3L4
uniprot id: A0A096N0W2
names: Similarity
messages: Belongs to the NAC-beta family.

9555:MMP9
gene id: 9555:MMP9
uniprot id: A0A096NX22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9555:MAPK1
gene id: 9555:MAPK1
uniprot id: A0A2I3LQV7
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

9555:PRKAG1
gene id: 9555:PRKAG1
uniprot id: A0A2I3MC84
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9555:ARL6
gene id: 9555:ARL6
uniprot id: A0A096MTK8
uniprot id: A0A2I3LZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9555:VPS29
gene id: 9555:VPS29
uniprot id: A0A096NEB1
uniprot id: A0A2I3MNT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9555:KRT36
gene id: 9555:KRT36
uniprot id: A0A096P5M5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:ZHX2
gene id: 9555:ZHX2
uniprot id: A0A096MVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9555:GCLM
gene id: 9555:GCLM
uniprot id: A0A096MPX6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9555:EIF2D
gene id: 9555:EIF2D
uniprot id: A0A096NF95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9555:RPRM
gene id: 9555:RPRM
uniprot id: A0A096N480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9555:MITF
gene id: 9555:MITF
uniprot id: A0A096N6Y8
uniprot id: A0A2I3M2E5
uniprot id: A0A2I3MYK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9555:INSM2
gene id: 9555:INSM2
uniprot id: A0A096NUL7
names: Subcellular Location Annotation
messages: Nucleus

9555:RPS14
gene id: 9555:RPS14
uniprot id: A0A2I3LIT8
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9555:PIGK
gene id: 9555:PIGK
uniprot id: A0A8I5QZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9555:LOC103875502
gene id: 9555:LOC103875502
uniprot id: A0A2I3LLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

9555:MYSM1
gene id: 9555:MYSM1
uniprot id: A0A096N6J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

9555:OSM
gene id: 9555:OSM
uniprot id: A0A096NJG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

9555:TMED5
gene id: 9555:TMED5
uniprot id: A0A096MZU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9555:MASP1
gene id: 9555:MASP1
uniprot id: A0A2I3LZ84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CFL2
gene id: 9555:CFL2
uniprot id: A0A096NLX4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9555:UBE2I
gene id: 9555:UBE2I
uniprot id: A0A2I3M9Y2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:SPATA6L
gene id: 9555:SPATA6L
uniprot id: A0A096P1M6
uniprot id: A0A2I3MIR5
names: Similarity
messages: Belongs to the SPATA6 family.

9555:CSF1
gene id: 9555:CSF1
uniprot id: A0A2I3LVH4
names: Function
names: Subunit
messages: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
messages: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

9555:MAP3K11
gene id: 9555:MAP3K11
uniprot id: A0A096N4Z8
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9555:BCL2L1
gene id: 9555:BCL2L1
uniprot id: A0A8I5MVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9555:PCYT2
gene id: 9555:PCYT2
uniprot id: A0A096NTK3
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9555:OLR120
gene id: 9555:OLR120
uniprot id: A9L8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:NLRP12
gene id: 9555:NLRP12
uniprot id: A0A0A0MVP9
uniprot id: A9L902
names: Similarity
messages: Belongs to the NLRP family.

9555:GABRP
gene id: 9555:GABRP
uniprot id: A0A096ND13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:ZNRF3
gene id: 9555:ZNRF3
uniprot id: A0A096NRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane
messages: Membrane

9555:GSPT1
gene id: 9555:GSPT1
uniprot id: A0A096NLR6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9555:B4GALT7
gene id: 9555:B4GALT7
uniprot id: A0A096ND10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9555:LSM7
gene id: 9555:LSM7
uniprot id: A0A8I5N5R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9555:SLC30A8
gene id: 9555:SLC30A8
uniprot id: A0A096MLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

9555:ROR1
gene id: 9555:ROR1
uniprot id: A0A096N7B7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PPAT
gene id: 9555:PPAT
uniprot id: A0A096NDS3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9555:PIP4P1
gene id: 9555:PIP4P1
uniprot id: A0A096NNL4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9555:EBAG9
gene id: 9555:EBAG9
uniprot id: A0A096N0L2
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9555:RAPSN
gene id: 9555:RAPSN
uniprot id: A0A096N391
names: Similarity
messages: Belongs to the RAPsyn family.

9555:ZNF500
gene id: 9555:ZNF500
uniprot id: A0A096NLG7
names: Subcellular Location Annotation
messages: Nucleus

9555:IFT20
gene id: 9555:IFT20
uniprot id: A0A2I3MCM8
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9555:LOC101016765
gene id: 9555:LOC101016765
uniprot id: A0A096MPD3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LOC108587426
gene id: 9555:LOC108587426
uniprot id: A0A096NCX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:IL22
gene id: 9555:IL22
uniprot id: A0A096NE66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9555:CYP2C8
gene id: 9555:CYP2C8
uniprot id: A0A2I3LGU8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:SBK2
gene id: 9555:SBK2
uniprot id: A0A0A0MUM0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:RASGRP3
gene id: 9555:RASGRP3
uniprot id: A0A096NYN6
uniprot id: A0A8I5N5V4
names: Similarity
messages: Belongs to the RASGRP family.

9555:EXOSC4
gene id: 9555:EXOSC4
uniprot id: A0A096P3J0
names: Subcellular Location Annotation
messages: Cytoplasm

9555:OSBPL8
gene id: 9555:OSBPL8
uniprot id: A0A2I3NE38
names: Similarity
messages: Belongs to the OSBP family.

9555:UBP1
gene id: 9555:UBP1
uniprot id: A0A096N7N3
uniprot id: A0A2I3LMV6
uniprot id: A0A2I3NGH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9555:EIF2B4
gene id: 9555:EIF2B4
uniprot id: A0A2I3MF81
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9555:CTLA4
gene id: 9555:CTLA4
uniprot id: Q9BDN7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9555:AHDC1
gene id: 9555:AHDC1
uniprot id: A0A096N521
names: Subcellular Location Annotation
messages: Nucleus

9555:MYH10
gene id: 9555:MYH10
uniprot id: A0A096P2V3
uniprot id: A0A2I3LJS5
uniprot id: A0A2I3NAJ8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9555:RFLNA
gene id: 9555:RFLNA
uniprot id: A0A096N8W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9555:TLX1
gene id: 9555:TLX1
uniprot id: A0A096P6B4
names: Subcellular Location Annotation
messages: Nucleus

9555:TOR1B
gene id: 9555:TOR1B
uniprot id: A0A096P0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9555:SHROOM2
gene id: 9555:SHROOM2
uniprot id: A0A096N231
uniprot id: A0A096N336
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9555:SUMF1
gene id: 9555:SUMF1
uniprot id: A0A096N097
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9555:ELAVL1
gene id: 9555:ELAVL1
uniprot id: A0A096P0K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9555:TUBGCP4
gene id: 9555:TUBGCP4
uniprot id: A0A096N6U6
uniprot id: A9X1B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9555:RIPPLY1
gene id: 9555:RIPPLY1
uniprot id: A0A096NPB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9555:ASXL1
gene id: 9555:ASXL1
uniprot id: A0A2I3M1N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9555:FFAR1
gene id: 9555:FFAR1
uniprot id: A0A2I3N538
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:AMD1
gene id: 9555:AMD1
uniprot id: A0A096NF29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9555:RPL30
gene id: 9555:RPL30
uniprot id: A0A2I3LTH8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9555:SLC45A3
gene id: 9555:SLC45A3
uniprot id: A0A096MUG2
names: Subcellular Location Annotation
messages: Membrane

9555:PKNOX1
gene id: 9555:PKNOX1
uniprot id: A0A096NIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9555:TTC39C
gene id: 9555:TTC39C
uniprot id: A0A096MYP9
names: Similarity
messages: Belongs to the TTC39 family.

9555:LOC101021626
gene id: 9555:LOC101021626
uniprot id: A0A8I5QZ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:LEP
gene id: 9555:LEP
uniprot id: A0A096MW62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9555:LHX4
gene id: 9555:LHX4
uniprot id: A0A096MXS7
names: Subcellular Location Annotation
messages: Nucleus

9555:MRPS16
gene id: 9555:MRPS16
uniprot id: A0A096P4P0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9555:DNA2
gene id: 9555:DNA2
uniprot id: A0A096P527
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9555:LOC101017417
gene id: 9555:LOC101017417
uniprot id: A0A096MR16
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:TCP11L2
gene id: 9555:TCP11L2
uniprot id: A0A096N8X4
names: Similarity
messages: Belongs to the TCP11 family.

9555:SFXN2
gene id: 9555:SFXN2
uniprot id: A0A096P6F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9555:PFN3
gene id: 9555:PFN3
uniprot id: A0A8I5NC12
names: Similarity
messages: Belongs to the profilin family.

9555:ADAMTS14
gene id: 9555:ADAMTS14
uniprot id: A0A096P4V6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:ESS2
gene id: 9555:ESS2
uniprot id: A0A096NS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9555:EFNA1
gene id: 9555:EFNA1
uniprot id: A0A096N996
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:RDH12
gene id: 9555:RDH12
uniprot id: A0A096NVQ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:PRKCI
gene id: 9555:PRKCI
uniprot id: A0A096N5E6
uniprot id: A0A2I3M796
uniprot id: A0A2I3N5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9555:GRIA4
gene id: 9555:GRIA4
uniprot id: A0A096MR99
uniprot id: A0A2I3MYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:TNPO2
gene id: 9555:TNPO2
uniprot id: A0A0A0MW54
names: Subcellular Location Annotation
messages: Cytoplasm

9555:FAM53B
gene id: 9555:FAM53B
uniprot id: A0A096NU59
uniprot id: A0A8I5N187
names: Similarity
messages: Belongs to the FAM53 family.

9555:LOC101011357
gene id: 9555:LOC101011357
uniprot id: A0A096MP40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9555:TTC4
gene id: 9555:TTC4
uniprot id: A0A096NA39
names: Similarity
messages: Belongs to the TTC4 family.

9555:ITM2C
gene id: 9555:ITM2C
uniprot id: A0A096NPP5
uniprot id: A0A2I3NI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9555:EMG1
gene id: 9555:EMG1
uniprot id: A0A096N676
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9555:IDH1
gene id: 9555:IDH1
uniprot id: A0A096MWT5
uniprot id: A0A8I5NP05
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9555:EXTL3
gene id: 9555:EXTL3
uniprot id: A0A096NYB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:PEX1
gene id: 9555:PEX1
uniprot id: A0A096NFM3
uniprot id: A0A096NQC4
uniprot id: A0A2I3NCZ7
uniprot id: A0A8I5N2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9555:SERINC4
gene id: 9555:SERINC4
uniprot id: A9X1C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9555:USP1
gene id: 9555:USP1
uniprot id: A0A096MS83
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9555:DNAJA4
gene id: 9555:DNAJA4
uniprot id: A0A2I3LY88
names: Subcellular Location Annotation
messages: Membrane

9555:PANX3
gene id: 9555:PANX3
uniprot id: A0A096N4L5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9555:SNX3
gene id: 9555:SNX3
uniprot id: B0CM46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9555:LPCAT3
gene id: 9555:LPCAT3
uniprot id: A0A096MST4
names: Subcellular Location Annotation
messages: Membrane

9555:MRPS25
gene id: 9555:MRPS25
uniprot id: A0A2I3MNF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9555:LOC101017479
gene id: 9555:LOC101017479
uniprot id: A0A2I3N3L3
names: Similarity
messages: Belongs to the cystatin family.

9555:GRIK3
gene id: 9555:GRIK3
uniprot id: A0A2I3MF13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:EIF4EBP1
gene id: 9555:EIF4EBP1
uniprot id: A0A096NXN8
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9555:SPRY1
gene id: 9555:SPRY1
uniprot id: A0A096NGC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9555:LOC101005189
gene id: 9555:LOC101005189
uniprot id: A0A2I3M9T4
uniprot id: A0A2I3MHV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family.
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9555:TNKS
gene id: 9555:TNKS
uniprot id: A0A096NPS8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:PSMA1
gene id: 9555:PSMA1
uniprot id: A0A096N1M9
uniprot id: A0A2I3LG13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9555:LOC101021712
gene id: 9555:LOC101021712
uniprot id: A0A096MKM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:SIM1
gene id: 9555:SIM1
uniprot id: A0A2I3MGA3
names: Subcellular Location Annotation
messages: Nucleus

9555:CHST12
gene id: 9555:CHST12
uniprot id: A0A096NCX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:GET3
gene id: 9555:GET3
uniprot id: A0A0A0MVE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9555:CER1
gene id: 9555:CER1
uniprot id: A0A096P1I6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:CDC14A
gene id: 9555:CDC14A
uniprot id: A0A2I3LXT1
uniprot id: A0A2I3MKZ0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9555:LARS2
gene id: 9555:LARS2
uniprot id: A0A096MSM0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9555:FCGR3A
gene id: 9555:FCGR3A
uniprot id: Q09TM2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G, to form a functional receptor complex. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (By similarity). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (By similarity). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (By similarity).
messages: Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG1 and IgG2.
messages: Lymphocytes and monocytes.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation. Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).
messages: Secreted
messages: Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.

9555:NXPH1
gene id: 9555:NXPH1
uniprot id: A0A096NWV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9555:SLC12A1
gene id: 9555:SLC12A1
uniprot id: A0A096NM06
uniprot id: A0A2I3N926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9555:MAGI1
gene id: 9555:MAGI1
uniprot id: A0A096MRM4
uniprot id: A0A096NG20
uniprot id: A0A2I3MTF5
names: Subcellular Location Annotation
messages: Membrane

9555:RORB
gene id: 9555:RORB
uniprot id: A0A096P1S6
uniprot id: A0A8I5N0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:KRT39
gene id: 9555:KRT39
uniprot id: A0A096P5J3
names: Similarity
messages: Belongs to the intermediate filament family.

9555:GADD45GIP1
gene id: 9555:GADD45GIP1
uniprot id: A0A0A0MVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9555:GALNT12
gene id: 9555:GALNT12
uniprot id: A0A096P120
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:HOXB13
gene id: 9555:HOXB13
uniprot id: A0A8I5R7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9555:HPX
gene id: 9555:HPX
uniprot id: A0A096N345
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9555:ASPH
gene id: 9555:ASPH
uniprot id: A0A2I3LD28
uniprot id: A0A2I3MAB3
uniprot id: A0A2I3MLG2
uniprot id: A0A2I3MQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9555:MEGF11
gene id: 9555:MEGF11
uniprot id: A0A2I3MG03
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GIPC1
gene id: 9555:GIPC1
uniprot id: A0A0A0MVP6
names: Similarity
messages: Belongs to the GIPC family.

9555:MAP1LC3A
gene id: 9555:MAP1LC3A
uniprot id: A0A2I3MQN7
names: Similarity
messages: Belongs to the ATG8 family.

9555:UBE2U
gene id: 9555:UBE2U
uniprot id: A0A2I3NC58
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:GABRB1
gene id: 9555:GABRB1
uniprot id: A0A096MTC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:NAA25
gene id: 9555:NAA25
uniprot id: A0A096NXQ6
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9555:CLDN23
gene id: 9555:CLDN23
uniprot id: A0A8I5NV52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:BYSL
gene id: 9555:BYSL
uniprot id: A8MN32
names: Similarity
messages: Belongs to the bystin family.

9555:NFIX
gene id: 9555:NFIX
uniprot id: A0A0A0MVZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9555:MGA
gene id: 9555:MGA
uniprot id: A0A2I3MUK3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:DUSP13
gene id: 9555:DUSP13
uniprot id: A0A096P4J7
uniprot id: A0A2I3LCB6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:OXSM
gene id: 9555:OXSM
uniprot id: A0A096MP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9555:CRYBA4
gene id: 9555:CRYBA4
uniprot id: A0A096NRG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9555:CASKIN2
gene id: 9555:CASKIN2
uniprot id: A0A096NSV7
names: Subcellular Location Annotation
messages: Cytoplasm

9555:CHPF2
gene id: 9555:CHPF2
uniprot id: A0A096NFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9555:ACTA2
gene id: 9555:ACTA2
uniprot id: A0A096P5E0
names: Similarity
messages: Belongs to the actin family.

9555:UBALD2
gene id: 9555:UBALD2
uniprot id: A0A096NT32
names: Similarity
messages: Belongs to the UBALD family.

9555:PCID2
gene id: 9555:PCID2
uniprot id: A9X174
names: Similarity
messages: Belongs to the CSN12 family.

9555:TMCO3
gene id: 9555:TMCO3
uniprot id: A0A8I5NQV1
names: Subcellular Location Annotation
messages: Membrane

9555:CYTB
gene id: 9555:CYTB
uniprot id: C6FE41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

9555:POP4
gene id: 9555:POP4
uniprot id: A0A0A0MW32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9555:MTERF1
gene id: 9555:MTERF1
uniprot id: A0A096NZU0
names: Similarity
messages: Belongs to the mTERF family.

9555:LOC103881122
gene id: 9555:LOC103881122
uniprot id: A0A8I5N7X0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9555:LOC101001487
gene id: 9555:LOC101001487
uniprot id: A0A2I3M1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:EYA3
gene id: 9555:EYA3
uniprot id: A0A2I3N5L1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9555:UROS
gene id: 9555:UROS
uniprot id: A0A096NSQ2
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9555:ADGRB2
gene id: 9555:ADGRB2
uniprot id: A0A096MW22
uniprot id: A0A2I3M7N7
uniprot id: A0A2I3NH10
names: Subcellular Location Annotation
messages: Membrane

9555:CADM2
gene id: 9555:CADM2
uniprot id: A0A2I3LWQ7
uniprot id: A0A2I3MHM2
names: Similarity
messages: Belongs to the nectin family.

9555:SEZ6
gene id: 9555:SEZ6
uniprot id: A0A2I3NEZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PRIMPOL
gene id: 9555:PRIMPOL
uniprot id: A0A096NA75
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9555:UTP14C
gene id: 9555:UTP14C
uniprot id: A0A2I3LX66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9555:TWISTNB
gene id: 9555:TWISTNB
uniprot id: A0A096NPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: nucleolus

9555:MMP10
gene id: 9555:MMP10
uniprot id: A0A096N6W9
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:PSMA2
gene id: 9555:PSMA2
uniprot id: A0A096MXE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9555:SEPTIN7
gene id: 9555:SEPTIN7
uniprot id: A0A2I3LIJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9555:IL1A
gene id: 9555:IL1A
uniprot id: A0A2I3LTT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9555:DDAH1
gene id: 9555:DDAH1
uniprot id: A0A2I3LYP1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9555:ST6GAL2
gene id: 9555:ST6GAL2
uniprot id: A0A096N576
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9555:LOC100998670
gene id: 9555:LOC100998670
uniprot id: A0A2I3MN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:C6H6orf120
gene id: 9555:C6H6orf120
uniprot id: A0A096MLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9555:THAP1
gene id: 9555:THAP1
uniprot id: A0A096N1X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9555:ARPC1B
gene id: 9555:ARPC1B
uniprot id: A0A096NQ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9555:ADSS1
gene id: 9555:ADSS1
uniprot id: A0A096NK30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9555:WNT7A
gene id: 9555:WNT7A
uniprot id: A0A8I5NIJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:TMEM39A
gene id: 9555:TMEM39A
uniprot id: A0A096MWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9555:POLD3
gene id: 9555:POLD3
uniprot id: A0A096MQG8
names: Subcellular Location Annotation
messages: Nucleus

9555:COX2
gene id: 9555:COX2
uniprot id: C3UVK6
uniprot id: P68297
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9555:SF3B6
gene id: 9555:SF3B6
uniprot id: A0A096MYT4
names: Subcellular Location Annotation
messages: Nucleus

9555:HOMER3
gene id: 9555:HOMER3
uniprot id: A0A0A0MU79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9555:SEMA6C
gene id: 9555:SEMA6C
uniprot id: A0A2I3LUD3
uniprot id: A9X191
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101010987
gene id: 9555:LOC101010987
uniprot id: A0A8I5N1W0
names: Similarity
messages: Belongs to the histone H2B family.

9555:EVC2
gene id: 9555:EVC2
uniprot id: A0A2I3LFA9
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9555:SLC7A6OS
gene id: 9555:SLC7A6OS
uniprot id: A0A096P003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9555:DEUP1
gene id: 9555:DEUP1
uniprot id: A0A096MXY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9555:TDRD7
gene id: 9555:TDRD7
uniprot id: A0A096P139
uniprot id: A0A8I5R8E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9555:PDE6G
gene id: 9555:PDE6G
uniprot id: A0A096NTH2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9555:LOC103883684
gene id: 9555:LOC103883684
uniprot id: A0A8I5NDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9555:IL18
gene id: 9555:IL18
uniprot id: A0A2I3NE92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9555:KCNK2
gene id: 9555:KCNK2
uniprot id: A0A2I3M4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:HEPH
gene id: 9555:HEPH
uniprot id: A0A096MX08
names: Similarity
messages: Belongs to the multicopper oxidase family.

9555:TCTN2
gene id: 9555:TCTN2
uniprot id: A0A096MQR2
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9555:SPAG9
gene id: 9555:SPAG9
uniprot id: A0A096P4M2
uniprot id: A0A096P4M3
names: Similarity
messages: Belongs to the JIP scaffold family.

9555:CRK
gene id: 9555:CRK
uniprot id: A0A096P297
names: Similarity
messages: Belongs to the CRK family.

9555:CA14
gene id: 9555:CA14
uniprot id: A0A096NQY2
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9555:ASIC4
gene id: 9555:ASIC4
uniprot id: B0CM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9555:TRIM22
gene id: 9555:TRIM22
uniprot id: A9L8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9555:KCNMB3
gene id: 9555:KCNMB3
uniprot id: A0A2I3N6H7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9555:DPY19L3
gene id: 9555:DPY19L3
uniprot id: A0A0A0MWP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9555:SEPTIN8
gene id: 9555:SEPTIN8
uniprot id: A9CB15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Presynapse
messages: synaptic vesicle membrane

9555:DLD
gene id: 9555:DLD
uniprot id: A0A096NF79
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9555:TOMM5
gene id: 9555:TOMM5
uniprot id: A0A2I3N161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:C13H9orf116
gene id: 9555:C13H9orf116
uniprot id: A0A2I3M723
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9555:HOXB6
gene id: 9555:HOXB6
uniprot id: A0A096P427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:PTS
gene id: 9555:PTS
uniprot id: A0A096NC15
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9555:PSMC1
gene id: 9555:PSMC1
uniprot id: A0A096N5G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9555:SPDL1
gene id: 9555:SPDL1
uniprot id: A0A096N5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9555:HHATL
gene id: 9555:HHATL
uniprot id: A0A096MZB3
names: Subcellular Location Annotation
messages: Membrane

9555:KCTD8
gene id: 9555:KCTD8
uniprot id: A0A096MLQ3
names: Subcellular Location Annotation
messages: Cell membrane

9555:SNX21
gene id: 9555:SNX21
uniprot id: A0A096NX33
uniprot id: A0A2I3MV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9555:GNRHR
gene id: 9555:GNRHR
uniprot id: A0A8I5NNU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TACC1
gene id: 9555:TACC1
uniprot id: A0A096N218
uniprot id: A0A2I3NI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9555:ELOA
gene id: 9555:ELOA
uniprot id: A0A096NAY4
names: Subcellular Location Annotation
messages: Nucleus

9555:SIGMAR1
gene id: 9555:SIGMAR1
uniprot id: A0A8I5R2J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9555:CALY
gene id: 9555:CALY
uniprot id: A0A8I5N1Z3
names: Similarity
messages: Belongs to the NSG family.

9555:DUSP16
gene id: 9555:DUSP16
uniprot id: A0A096NCT6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:ALX1
gene id: 9555:ALX1
uniprot id: A0A096MXS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9555:HSPA13
gene id: 9555:HSPA13
uniprot id: A0A2I3N693
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9555:FAM234B
gene id: 9555:FAM234B
uniprot id: A0A096MPT3
names: Similarity
messages: Belongs to the FAM234 family.

9555:KCNJ15
gene id: 9555:KCNJ15
uniprot id: A0A096N871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9555:UNC119
gene id: 9555:UNC119
uniprot id: A0A096P396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9555:GPBP1L1
gene id: 9555:GPBP1L1
uniprot id: A0A096ND91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9555:DMPK
gene id: 9555:DMPK
uniprot id: A0A0A0MXK6
uniprot id: A0A2I3N2L9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

9555:SPEM1
gene id: 9555:SPEM1
uniprot id: A0A096P2P9
names: Subcellular Location Annotation
messages: Membrane

9555:SNRPG
gene id: 9555:SNRPG
uniprot id: A0A2I3LWP6
uniprot id: A0A2I3M0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9555:RPLP2
gene id: 9555:RPLP2
uniprot id: A0A2I3MNA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9555:PSMD4
gene id: 9555:PSMD4
uniprot id: A9X198
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9555:LOC100998784
gene id: 9555:LOC100998784
uniprot id: A0A2I3MSK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9555:WDR48
gene id: 9555:WDR48
uniprot id: A0A096NAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9555:CAV1
gene id: 9555:CAV1
uniprot id: A0M8R6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9555:LOC101021227
gene id: 9555:LOC101021227
uniprot id: A0A8I5R6T8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:PSMA3
gene id: 9555:PSMA3
uniprot id: A0A096NVD3
uniprot id: A0A2I3LV86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9555:TIGD4
gene id: 9555:TIGD4
uniprot id: A0A096MMG9
names: Subcellular Location Annotation
messages: Nucleus

9555:TREH
gene id: 9555:TREH
uniprot id: A0A096MZ32
uniprot id: A0A096N7G8
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9555:HOPX
gene id: 9555:HOPX
uniprot id: A0A8I5R6B8
names: Subcellular Location Annotation
messages: Nucleus

9555:PPP4R2
gene id: 9555:PPP4R2
uniprot id: A0A2I3MTK4
names: Similarity
messages: Belongs to the PPP4R2 family.

9555:CRYGS
gene id: 9555:CRYGS
uniprot id: A0A096NCK3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9555:SMAD9
gene id: 9555:SMAD9
uniprot id: A0A096N7N2
uniprot id: A0A2I3MH57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9555:THNSL1
gene id: 9555:THNSL1
uniprot id: A0A096N5J2
names: Similarity
messages: Belongs to the threonine synthase family.

9555:TLCD4
gene id: 9555:TLCD4
uniprot id: A0A096NYV9
names: Subcellular Location Annotation
messages: Membrane

9555:RNF146
gene id: 9555:RNF146
uniprot id: A0A096MZY3
uniprot id: A0A2I3M2L6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9555:GPR155
gene id: 9555:GPR155
uniprot id: A0A096MTC8
names: Subcellular Location Annotation
messages: Membrane

9555:VSX1
gene id: 9555:VSX1
uniprot id: A0A096NVU9
uniprot id: A0A2I3LWE4
uniprot id: A0A2I3N593
names: Subcellular Location Annotation
messages: Nucleus

9555:STOML1
gene id: 9555:STOML1
uniprot id: A0A8I5MUZ1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9555:RFFL
gene id: 9555:RFFL
uniprot id: A0A096P3V7
uniprot id: A0A2I3LJI6
uniprot id: A0A2I3LR40
names: Subcellular Location Annotation
messages: Cell membrane

9555:SNCG
gene id: 9555:SNCG
uniprot id: A0A096P4D2
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9555:CCND2
gene id: 9555:CCND2
uniprot id: A0A8I5R9M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9555:GALNTL6
gene id: 9555:GALNTL6
uniprot id: A0A2I3M6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:ACOT13
gene id: 9555:ACOT13
uniprot id: A0A096N647
uniprot id: A0A2I3NCE5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9555:ITPR2
gene id: 9555:ITPR2
uniprot id: A0A096NBX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9555:FUS
gene id: 9555:FUS
uniprot id: A0A096NHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9555:RNF112
gene id: 9555:RNF112
uniprot id: A0A096P347
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:OAZ1
gene id: 9555:OAZ1
uniprot id: A0A0A0MX67
names: Similarity
messages: Belongs to the ODC antizyme family.

9555:AP3B1
gene id: 9555:AP3B1
uniprot id: A0A096MNX7
uniprot id: A0A096N6E4
uniprot id: A0A8I5N828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9555:C1D
gene id: 9555:C1D
uniprot id: A0A096MS73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9555:DAG1
gene id: 9555:DAG1
uniprot id: A0A096MT62
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9555:MFAP3
gene id: 9555:MFAP3
uniprot id: A0A8I5R2R8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:NDUFS2
gene id: 9555:NDUFS2
uniprot id: A0A096NQK6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9555:PRR15
gene id: 9555:PRR15
uniprot id: A0A096MNH4
names: Similarity
messages: Belongs to the PRR15 family.

9555:CLCF1
gene id: 9555:CLCF1
uniprot id: A0A096NQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9555:KPNA1
gene id: 9555:KPNA1
uniprot id: A0A096MMP3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9555:ANK3
gene id: 9555:ANK3
uniprot id: A0A096P563
uniprot id: A0A2I3MP98
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9555:TNKS2
gene id: 9555:TNKS2
uniprot id: A0A096P5H6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9555:HTR1B
gene id: 9555:HTR1B
uniprot id: A0A096N6D8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9555:LOC101000558
gene id: 9555:LOC101000558
uniprot id: A0A096NEG6
uniprot id: A0A2I3LHG9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9555:GAD1
gene id: 9555:GAD1
uniprot id: A0A096NZH1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9555:CAPN5
gene id: 9555:CAPN5
uniprot id: A0A096N342
names: Similarity
messages: Belongs to the peptidase C2 family.

9555:ANP32E
gene id: 9555:ANP32E
uniprot id: A0A096N087
uniprot id: A0A2I3MVQ5
names: Similarity
messages: Belongs to the ANP32 family.

9555:MCM5
gene id: 9555:MCM5
uniprot id: A0A096NJS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9555:COPA
gene id: 9555:COPA
uniprot id: A0A096NP91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9555:ARRB1
gene id: 9555:ARRB1
uniprot id: A0A096MN07
uniprot id: A0A096MW32
names: Similarity
messages: Belongs to the arrestin family.

9555:PGM1
gene id: 9555:PGM1
uniprot id: A0A096NA34
uniprot id: A0A2I3N9B2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9555:EGFR
gene id: 9555:EGFR
uniprot id: A0A096MVJ9
uniprot id: A0A2I3ML37
uniprot id: A0A8I5NAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9555:TRPT1
gene id: 9555:TRPT1
uniprot id: A0A096MWG4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9555:PCMT1
gene id: 9555:PCMT1
uniprot id: A0A096NW19
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9555:STK4
gene id: 9555:STK4
uniprot id: A4K2M3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3 (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 and SCRIB in the presence of DLG5.
messages: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity).
messages: Nucleus
messages: Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog (By similarity).
messages: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

9555:LOC101024697
gene id: 9555:LOC101024697
uniprot id: A0A096NJQ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:SMPD2
gene id: 9555:SMPD2
uniprot id: A0A096MU47
uniprot id: A0A8I5NJJ9
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9555:RECQL5
gene id: 9555:RECQL5
uniprot id: A0A2I3N6C7
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9555:GNG10
gene id: 9555:GNG10
uniprot id: A0A096P0W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9555:OCLN
gene id: 9555:OCLN
uniprot id: A0A096N8G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9555:LOC101015671
gene id: 9555:LOC101015671
uniprot id: A0A096NGE3
uniprot id: A0A2I3M7M1
uniprot id: A0A2I3N058
names: Similarity
messages: Belongs to the Luc7 family.

9555:EGFL7
gene id: 9555:EGFL7
uniprot id: A0A096NRS1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:KRR1
gene id: 9555:KRR1
uniprot id: A0A096NP56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9555:AMOTL2
gene id: 9555:AMOTL2
uniprot id: A0A096N088
uniprot id: A0A8I5NV60
names: Similarity
messages: Belongs to the angiomotin family.

9555:CDH20
gene id: 9555:CDH20
uniprot id: A0A096MT19
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:NCBP1
gene id: 9555:NCBP1
uniprot id: A0A096P136
uniprot id: A0A2I3MJB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9555:TMSB4X
gene id: 9555:TMSB4X
uniprot id: A0A2I3MP40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9555:HMGN3
gene id: 9555:HMGN3
uniprot id: A0A2I3N3M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

9555:LOC100999447
gene id: 9555:LOC100999447
uniprot id: A0A096N7I9
names: Subcellular Location Annotation
messages: Membrane

9555:FRAT1
gene id: 9555:FRAT1
uniprot id: A0A096P5X9
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

9555:CAPN13
gene id: 9555:CAPN13
uniprot id: A0A096NFQ7
uniprot id: A0A2I3N1D2
names: Similarity
messages: Belongs to the peptidase C2 family.

9555:KMT5B
gene id: 9555:KMT5B
uniprot id: A0A2I3LWW0
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9555:CSN3
gene id: 9555:CSN3
uniprot id: A0A096MZ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9555:PWWP3B
gene id: 9555:PWWP3B
uniprot id: A0A8I5NEJ6
names: Similarity
messages: Belongs to the PWWP3A family.

9555:PDE3B
gene id: 9555:PDE3B
uniprot id: A0A096MMB6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9555:BPIFC
gene id: 9555:BPIFC
uniprot id: A9CB43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9555:ERBIN
gene id: 9555:ERBIN
uniprot id: A0A096MTT1
uniprot id: A0A2I3MAP2
uniprot id: A0A8I5R141
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9555:TNFAIP3
gene id: 9555:TNFAIP3
uniprot id: A0A096NQC6
uniprot id: A0A8I5MZ59
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:LMF2
gene id: 9555:LMF2
uniprot id: A0A096NL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9555:ARMCX1
gene id: 9555:ARMCX1
uniprot id: A0A096N6K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9555:SLC35E1
gene id: 9555:SLC35E1
uniprot id: A0A0A0MX00
names: Subcellular Location Annotation
messages: Membrane

9555:MAB21L1
gene id: 9555:MAB21L1
uniprot id: A0A096ML90
uniprot id: A0A096MXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9555:ATG4A
gene id: 9555:ATG4A
uniprot id: A0A096N761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9555:NSF
gene id: 9555:NSF
uniprot id: A0A096P679
uniprot id: A0A2I3LW66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9555:PIAS4
gene id: 9555:PIAS4
uniprot id: A0A0A0MWY6
names: Similarity
messages: Belongs to the PIAS family.

9555:PROZ
gene id: 9555:PROZ
uniprot id: A9X173
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PAX2
gene id: 9555:PAX2
uniprot id: A0A096P695
names: Subcellular Location Annotation
messages: Nucleus

9555:UGGT2
gene id: 9555:UGGT2
uniprot id: A0A096NGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9555:EIF5
gene id: 9555:EIF5
uniprot id: A0A096NJY0
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9555:ST14
gene id: 9555:ST14
uniprot id: A0A096N6P3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:BCAS2
gene id: 9555:BCAS2
uniprot id: A0A096MKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9555:CEP170B
gene id: 9555:CEP170B
uniprot id: A0A096NK34
names: Similarity
messages: Belongs to the CEP170 family.

9555:CRYZ
gene id: 9555:CRYZ
uniprot id: A0A096N712
uniprot id: A0A096NZ28
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9555:GADD45A
gene id: 9555:GADD45A
uniprot id: A0A096N8C4
names: Similarity
messages: Belongs to the GADD45 family.

9555:IGFBP3
gene id: 9555:IGFBP3
uniprot id: A0A096MWE4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:DDX6
gene id: 9555:DDX6
uniprot id: A0A096MW74
names: Similarity
messages: Belongs to the DEAD box helicase family.

9555:JPH1
gene id: 9555:JPH1
uniprot id: A0A096NGB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9555:ALOX15
gene id: 9555:ALOX15
uniprot id: A0A096P2G1
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PRND
gene id: 9555:PRND
uniprot id: A0A8I5NPX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9555:TIMM22
gene id: 9555:TIMM22
uniprot id: A0A096P292
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9555:ELOVL6
gene id: 9555:ELOVL6
uniprot id: A0A096MRK4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9555:FOXI2
gene id: 9555:FOXI2
uniprot id: A0A096NSS7
names: Subcellular Location Annotation
messages: Nucleus

9555:GATA4
gene id: 9555:GATA4
uniprot id: A0A2I3MF62
names: Subcellular Location Annotation
messages: Nucleus

9555:C12H11orf49
gene id: 9555:C12H11orf49
uniprot id: A0A096N7A7
uniprot id: A0A2I3LKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9555:LOC101007596
gene id: 9555:LOC101007596
uniprot id: A0A096NCB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9555:KCNA4
gene id: 9555:KCNA4
uniprot id: A0A8I5NUU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9555:RNF114
gene id: 9555:RNF114
uniprot id: A0A8I5N173
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9555:PDIA3
gene id: 9555:PDIA3
uniprot id: A9X1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9555:HIGD2A
gene id: 9555:HIGD2A
uniprot id: A0A8I5MWD5
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9555:LOC101012199
gene id: 9555:LOC101012199
uniprot id: A0A8I5NC44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9555:MED30
gene id: 9555:MED30
uniprot id: A0A096NDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9555:FBXO31
gene id: 9555:FBXO31
uniprot id: A0A096MYS5
uniprot id: A0A096N5W8
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

9555:LOC100997213
gene id: 9555:LOC100997213
uniprot id: A0A096P2V0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9555:CYSLTR2
gene id: 9555:CYSLTR2
uniprot id: A0A096MYP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:SF3A3
gene id: 9555:SF3A3
uniprot id: A0A096MMW9
names: Similarity
messages: Belongs to the SF3A3 family.

9555:APOO
gene id: 9555:APOO
uniprot id: A0A096MU27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9555:FAR2
gene id: 9555:FAR2
uniprot id: A0A096N5U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9555:GPR157
gene id: 9555:GPR157
uniprot id: A0A096N790
names: Subcellular Location Annotation
messages: Membrane

9555:LOC101004600
gene id: 9555:LOC101004600
uniprot id: A0A2I3MTM8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9555:HSD17B3
gene id: 9555:HSD17B3
uniprot id: A0A096P266
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:RPS4X
gene id: 9555:RPS4X
uniprot id: A0A096MLU8
uniprot id: A9CB07
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9555:NR1H2
gene id: 9555:NR1H2
uniprot id: A0A0A0MUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:KATNAL2
gene id: 9555:KATNAL2
uniprot id: A0A096NYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9555:GOSR1
gene id: 9555:GOSR1
uniprot id: A0A096P3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9555:DOCK1
gene id: 9555:DOCK1
uniprot id: A0A096NSS0
names: Similarity
messages: Belongs to the DOCK family.

9555:MIGA2
gene id: 9555:MIGA2
uniprot id: A0A8J8YJB9
uniprot id: B0CM94
names: Similarity
messages: Belongs to the mitoguardin family.

9555:RPL18
gene id: 9555:RPL18
uniprot id: A0A096MNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9555:ZKSCAN1
gene id: 9555:ZKSCAN1
uniprot id: A0A096MV28
names: Subcellular Location Annotation
messages: Nucleus

9555:MAK16
gene id: 9555:MAK16
uniprot id: A0A096NYI0
names: Similarity
messages: Belongs to the MAK16 family.

9555:GJD3
gene id: 9555:GJD3
uniprot id: A0A096P5G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9555:SH3GLB1
gene id: 9555:SH3GLB1
uniprot id: A0A096NBE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9555:KRT34
gene id: 9555:KRT34
uniprot id: A0A2I3MSY3
names: Similarity
messages: Belongs to the intermediate filament family.

9555:CHRM1
gene id: 9555:CHRM1
uniprot id: A0A096NB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9555:KCTD2
gene id: 9555:KCTD2
uniprot id: A0A096NST3
names: Subcellular Location Annotation
messages: Cell membrane

9555:CTBP2
gene id: 9555:CTBP2
uniprot id: A0A096NU64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9555:TAX1BP3
gene id: 9555:TAX1BP3
uniprot id: A0A096P2E5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9555:SLC17A2
gene id: 9555:SLC17A2
uniprot id: A0A096NLF6
uniprot id: A0A2I3LQ19
uniprot id: A0A8I5NK71
names: Subcellular Location Annotation
messages: Membrane

9555:ACVR2B
gene id: 9555:ACVR2B
uniprot id: A0A096NC93
uniprot id: A0A2I3LN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9555:AQP12B
gene id: 9555:AQP12B
uniprot id: A0A2I3LYW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:BAK1
gene id: 9555:BAK1
uniprot id: A0A2I3MUA8
uniprot id: A0A8I5MWU4
names: Similarity
messages: Belongs to the Bcl-2 family.

9555:P2RY1
gene id: 9555:P2RY1
uniprot id: A0A096MLQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TNFSF13B
gene id: 9555:TNFSF13B
uniprot id: A0A096MX24
uniprot id: A0A2I3M5C7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9555:TEK
gene id: 9555:TEK
uniprot id: A0A096P1E5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:TYMS
gene id: 9555:TYMS
uniprot id: A0A096N9Z2
uniprot id: A0A8I5R604
names: Similarity
messages: Belongs to the thymidylate synthase family.

9555:UBE2G2
gene id: 9555:UBE2G2
uniprot id: A0A2I3LSR7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:LOC108584506
gene id: 9555:LOC108584506
uniprot id: A0A2I3MZ68
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9555:TNMD
gene id: 9555:TNMD
uniprot id: A0A096MNM5
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9555:ALG8
gene id: 9555:ALG8
uniprot id: A0A096MVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:DUSP10
gene id: 9555:DUSP10
uniprot id: A0A096N7I5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9555:SLC46A3
gene id: 9555:SLC46A3
uniprot id: A0A096NEN5
names: Subcellular Location Annotation
messages: Membrane

9555:OR51B5
gene id: 9555:OR51B5
uniprot id: A9L8Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TVP23A
gene id: 9555:TVP23A
uniprot id: A0A096NLN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9555:IFIH1
gene id: 9555:IFIH1
uniprot id: A0A096NWE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9555:ELMO1
gene id: 9555:ELMO1
uniprot id: A0A096N5B1
uniprot id: A0A2I3LRU6
uniprot id: A0A8I5N4K7
uniprot id: A0A8I5NNI3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9555:LOC101007158
gene id: 9555:LOC101007158
uniprot id: A0A2I3LS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9555:NDUFA8
gene id: 9555:NDUFA8
uniprot id: A0A8I5NVG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9555:TMEM159
gene id: 9555:TMEM159
uniprot id: A0A2I3MLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9555:ZP4
gene id: 9555:ZP4
uniprot id: A0A096MQF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9555:HOGA1
gene id: 9555:HOGA1
uniprot id: A0A096P614
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9555:ADIPOR1
gene id: 9555:ADIPOR1
uniprot id: A0A096N3Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9555:CACNB3
gene id: 9555:CACNB3
uniprot id: A0A096MXG0
uniprot id: A0A2I3MEV8
uniprot id: A0A2I3MZU9
uniprot id: A0A2I3NDU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9555:MMP8
gene id: 9555:MMP8
uniprot id: A0A096NQR7
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:DACT3
gene id: 9555:DACT3
uniprot id: A0A0A0MXD5
names: Similarity
messages: Belongs to the dapper family.

9555:BMT2
gene id: 9555:BMT2
uniprot id: A0A096MXD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9555:MYBL2
gene id: 9555:MYBL2
uniprot id: A0A096NXB2
names: Subcellular Location Annotation
messages: Nucleus

9555:AGXT
gene id: 9555:AGXT
uniprot id: A0A096NXK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9555:WDFY1
gene id: 9555:WDFY1
uniprot id: A0A096NYF9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9555:CDC37L1
gene id: 9555:CDC37L1
uniprot id: A0A096P1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9555:MX2
gene id: 9555:MX2
uniprot id: A0A096NIY1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9555:SGCB
gene id: 9555:SGCB
uniprot id: A0A096NZ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9555:DMBX1
gene id: 9555:DMBX1
uniprot id: A0A096NBI1
names: Subcellular Location Annotation
messages: Nucleus

9555:ASRGL1
gene id: 9555:ASRGL1
uniprot id: A0A096NDC5
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9555:QRSL1
gene id: 9555:QRSL1
uniprot id: A0A096NR63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9555:CDKL1
gene id: 9555:CDKL1
uniprot id: A0A096NUW4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:SPA17
gene id: 9555:SPA17
uniprot id: A0A096MPS2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9555:RAB5IF
gene id: 9555:RAB5IF
uniprot id: A0A2I3MS51
uniprot id: A0A8I5N4Q8
names: Subcellular Location Annotation
messages: Membrane

9555:COCH
gene id: 9555:COCH
uniprot id: A0A096NXF5
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

9555:LOC101008565
gene id: 9555:LOC101008565
uniprot id: A0A096NGT8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9555:NUDT5
gene id: 9555:NUDT5
uniprot id: A0A096P3F4
uniprot id: A0A2I3NE09
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9555:PARD3
gene id: 9555:PARD3
uniprot id: A0A2I3LI80
uniprot id: A0A2I3MWC1
uniprot id: A0A2I3MXR0
uniprot id: A0A2I3N7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9555:SRC
gene id: 9555:SRC
uniprot id: A0A2I3M0W2
uniprot id: A0A2I3MCC2
uniprot id: A0A2I3N2L0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:ACTR2
gene id: 9555:ACTR2
uniprot id: A0A096P076
uniprot id: A0A2I3LLE2
names: Similarity
messages: Belongs to the actin family.

9555:PRXL2A
gene id: 9555:PRXL2A
uniprot id: A0A096P4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9555:SLC2A4
gene id: 9555:SLC2A4
uniprot id: A0A096P2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9555:BMP7
gene id: 9555:BMP7
uniprot id: A0A096NNJ3
names: Similarity
messages: Belongs to the TGF-beta family.

9555:UFL1
gene id: 9555:UFL1
uniprot id: A0A096MVC6
uniprot id: A0A096NDT9
names: Similarity
messages: Belongs to the UFL1 family.

9555:TAFA5
gene id: 9555:TAFA5
uniprot id: A0A8I5NJ49
uniprot id: A0A8I5R137
names: Similarity
messages: Belongs to the TAFA family.

9555:LOC101022490
gene id: 9555:LOC101022490
uniprot id: A0A096MP30
uniprot id: A0A2I3LCL1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9555:LOC101018895
gene id: 9555:LOC101018895
uniprot id: A0A1A9C8Q8
names: Similarity
messages: Belongs to the MHC class II family.

9555:ARHGAP32
gene id: 9555:ARHGAP32
uniprot id: A0A096MV13
uniprot id: A0A2I3MK83
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9555:FAM32A
gene id: 9555:FAM32A
uniprot id: A0A0A0MX01
names: Similarity
messages: Belongs to the FAM32 family.

9555:PSMC2
gene id: 9555:PSMC2
uniprot id: A0A096NGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9555:ASB6
gene id: 9555:ASB6
uniprot id: A0A096P0H3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:LOC108586901
gene id: 9555:LOC108586901
uniprot id: A0A096N461
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9555:SPX
gene id: 9555:SPX
uniprot id: A0A096NEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9555:POLR2G
gene id: 9555:POLR2G
uniprot id: A0A2I3MQI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9555:CACYBP
gene id: 9555:CACYBP
uniprot id: A0A096N8H5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9555:CRX
gene id: 9555:CRX
uniprot id: A0A0A0MV98
names: Subcellular Location Annotation
messages: Nucleus

9555:MMGT1
gene id: 9555:MMGT1
uniprot id: A0A096NGY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9555:IFNGR1
gene id: 9555:IFNGR1
uniprot id: A0A096NQT6
uniprot id: A0A2I3MGB2
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9555:TENT5C
gene id: 9555:TENT5C
uniprot id: A0A096MXW2
names: Similarity
messages: Belongs to the TENT family.

9555:RTN3
gene id: 9555:RTN3
uniprot id: A0A2I3LIZ9
uniprot id: A0A2I3LKE8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:GSG1L2
gene id: 9555:GSG1L2
uniprot id: A0A096P2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9555:INSIG1
gene id: 9555:INSIG1
uniprot id: A0A096NRW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9555:LOC101015409
gene id: 9555:LOC101015409
uniprot id: A0A096NQN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

9555:GPRC5D
gene id: 9555:GPRC5D
uniprot id: A0A2I3LMX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:IGFBP1
gene id: 9555:IGFBP1
uniprot id: A0A8I5MZC8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:PPM1A
gene id: 9555:PPM1A
uniprot id: A0A096NVG4
uniprot id: A0A2I3N2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9555:CMBL
gene id: 9555:CMBL
uniprot id: A0A096MSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9555:NTMT1
gene id: 9555:NTMT1
uniprot id: A0A096P0H4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9555:ST8SIA2
gene id: 9555:ST8SIA2
uniprot id: A0A2I3LKH1
uniprot id: A0A8I5NF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:MRPL20
gene id: 9555:MRPL20
uniprot id: A0A096NGL3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9555:LOC101005841
gene id: 9555:LOC101005841
uniprot id: A0A096MLZ6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:TPP1
gene id: 9555:TPP1
uniprot id: A0A096MQ92
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Melanosome

9555:ERN1
gene id: 9555:ERN1
uniprot id: A0A2I3N376
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:PLIN5
gene id: 9555:PLIN5
uniprot id: A0A0A0MX13
names: Similarity
messages: Belongs to the perilipin family.

9555:SEC31B
gene id: 9555:SEC31B
uniprot id: A0A096P687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9555:PLPPR5
gene id: 9555:PLPPR5
uniprot id: A0A8I5N3Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9555:PARD6B
gene id: 9555:PARD6B
uniprot id: A0A096NNP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9555:ESR2
gene id: 9555:ESR2
uniprot id: B6CK32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9555:TMEM41A
gene id: 9555:TMEM41A
uniprot id: A0A096NQB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9555:C12H11orf88
gene id: 9555:C12H11orf88
uniprot id: A0A096N6W8
names: Similarity
messages: Belongs to the HOATZ family.

9555:LPL
gene id: 9555:LPL
uniprot id: P49060
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Highest levels in the spinal cord.
messages: Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity).
messages: Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
messages: Secreted
messages: The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity).
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9555:SIAH3
gene id: 9555:SIAH3
uniprot id: A0A096NYW7
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9555:VSX2
gene id: 9555:VSX2
uniprot id: A0A096NRC0
names: Subcellular Location Annotation
messages: Nucleus

9555:DERL1
gene id: 9555:DERL1
uniprot id: A0A2I3LIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9555:LOC101024056
gene id: 9555:LOC101024056
uniprot id: A0A096NFZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:MACO1
gene id: 9555:MACO1
uniprot id: A0A096MT58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9555:SCP2
gene id: 9555:SCP2
uniprot id: A0A096NWA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9555:HOXA5
gene id: 9555:HOXA5
uniprot id: A9L940
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9555:IMPA2
gene id: 9555:IMPA2
uniprot id: A0A096ND98
uniprot id: A0A8I5NPC3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9555:LIX1
gene id: 9555:LIX1
uniprot id: A0A096N5D3
names: Similarity
messages: Belongs to the LIX1 family.

9555:ZIC1
gene id: 9555:ZIC1
uniprot id: A0A096N234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9555:RNF152
gene id: 9555:RNF152
uniprot id: A0A096NAU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9555:SEC22C
gene id: 9555:SEC22C
uniprot id: A0A096NWX8
uniprot id: A0A2I3NIE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9555:HEBP2
gene id: 9555:HEBP2
uniprot id: A0A096MWJ0
names: Similarity
messages: Belongs to the HEBP family.

9555:FOXN3
gene id: 9555:FOXN3
uniprot id: A0A096MNG4
uniprot id: A0A2I3N9V2
names: Subcellular Location Annotation
messages: Nucleus

9555:DPYS
gene id: 9555:DPYS
uniprot id: A0A096MSS6
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9555:GTF2B
gene id: 9555:GTF2B
uniprot id: A0A096N3D1
names: Similarity
messages: Belongs to the TFIIB family.

9555:CAPN10
gene id: 9555:CAPN10
uniprot id: A0A096NA77
names: Similarity
messages: Belongs to the peptidase C2 family.

9555:BAZ2A
gene id: 9555:BAZ2A
uniprot id: A0A2I3MGP6
names: Similarity
messages: Belongs to the WAL family.

9555:XRCC3
gene id: 9555:XRCC3
uniprot id: A0A096NJZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9555:ATL2
gene id: 9555:ATL2
uniprot id: A0A096N148
uniprot id: A0A2I3MLJ6
uniprot id: A0A2I3N888
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:CDK1
gene id: 9555:CDK1
uniprot id: A0A096P561
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:FAM171B
gene id: 9555:FAM171B
uniprot id: A0A096N7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9555:GALR2
gene id: 9555:GALR2
uniprot id: A0A096NT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:SLC39A6
gene id: 9555:SLC39A6
uniprot id: A0A096MUA8
uniprot id: A0A096MX70
names: Subcellular Location Annotation
messages: Membrane

9555:MRPL9
gene id: 9555:MRPL9
uniprot id: A9X1A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9555:LY6D
gene id: 9555:LY6D
uniprot id: A0A096MSF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:PCMTD1
gene id: 9555:PCMTD1
uniprot id: A0A096MXP2
uniprot id: A0A2I3MQT8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9555:ATP1B4
gene id: 9555:ATP1B4
uniprot id: A0A096N5U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9555:MFSD3
gene id: 9555:MFSD3
uniprot id: A0A096N3E3
names: Subcellular Location Annotation
messages: Membrane

9555:KDELR1
gene id: 9555:KDELR1
uniprot id: A0A0A0MWV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:LOC101024192
gene id: 9555:LOC101024192
uniprot id: A0A096NJ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:CKMT2
gene id: 9555:CKMT2
uniprot id: A0A096MNU5
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9555:CENPQ
gene id: 9555:CENPQ
uniprot id: A0A096NIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9555:PPIL3
gene id: 9555:PPIL3
uniprot id: A0A096MW52
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:AIDA
gene id: 9555:AIDA
uniprot id: A0A096MZU2
names: Similarity
messages: Belongs to the AIDA family.

9555:OPN1SW
gene id: 9555:OPN1SW
uniprot id: A0A096NUC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9555:LOC101012883
gene id: 9555:LOC101012883
uniprot id: A0A096N6X8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9555:ASB8
gene id: 9555:ASB8
uniprot id: A0A8I5R912
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9555:CLEC12B
gene id: 9555:CLEC12B
uniprot id: A0A096MQX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:LAMA3
gene id: 9555:LAMA3
uniprot id: A0A2I3LRD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:RPS27A
gene id: 9555:RPS27A
uniprot id: A0A2I3LH01
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9555:TSPAN15
gene id: 9555:TSPAN15
uniprot id: A0A096P4Z1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ATP6V0A2
gene id: 9555:ATP6V0A2
uniprot id: A0A096N771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9555:NPY1R
gene id: 9555:NPY1R
uniprot id: A0A8I5R9R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:FSCN3
gene id: 9555:FSCN3
uniprot id: A9RA80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9555:TMSB15A
gene id: 9555:TMSB15A
uniprot id: A0A2I3N094
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9555:TPRG1
gene id: 9555:TPRG1
uniprot id: A0A2I3LT00
names: Similarity
messages: Belongs to the TPRG1 family.

9555:WDR76
gene id: 9555:WDR76
uniprot id: A9X1C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9555:HLX
gene id: 9555:HLX
uniprot id: A0A096N7I4
names: Subcellular Location Annotation
messages: Nucleus

9555:FAM162A
gene id: 9555:FAM162A
uniprot id: A0A096N0Q1
uniprot id: A0A8I5MVE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9555:ZDHHC7
gene id: 9555:ZDHHC7
uniprot id: A0A2I3MZH6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:GBP1
gene id: 9555:GBP1
uniprot id: A0A2I3NC35
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9555:P4HA2
gene id: 9555:P4HA2
uniprot id: A9CB24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9555:INHBA
gene id: 9555:INHBA
uniprot id: A0A096NQU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9555:LOC101014679
gene id: 9555:LOC101014679
uniprot id: A0A2I3M9L6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9555:NGB
gene id: 9555:NGB
uniprot id: A0A8I5NP85
names: Similarity
messages: Belongs to the globin family.

9555:TRUB1
gene id: 9555:TRUB1
uniprot id: A0A096NTS8
uniprot id: A0A8I5NIM5
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9555:GMNN
gene id: 9555:GMNN
uniprot id: A0A096NLD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9555:EREG
gene id: 9555:EREG
uniprot id: A0A8I5P446
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TBC1D7
gene id: 9555:TBC1D7
uniprot id: A0A096NL01
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9555:PRKAA1
gene id: 9555:PRKAA1
uniprot id: A0A096N9P0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9555:CPSF6
gene id: 9555:CPSF6
uniprot id: A0A2I3LQP0
uniprot id: A0A2I3MBH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

9555:RPF2
gene id: 9555:RPF2
uniprot id: A0A096MU50
uniprot id: A0A8I5R1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9555:CDC37
gene id: 9555:CDC37
uniprot id: A0A0A0MX18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9555:GRM4
gene id: 9555:GRM4
uniprot id: A0A2I3LLZ3
uniprot id: A0A2I3M1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9555:SYNJ2
gene id: 9555:SYNJ2
uniprot id: A0A096NWZ4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9555:RIC8B
gene id: 9555:RIC8B
uniprot id: A0A096MRK9
uniprot id: A0A2I3LE00
uniprot id: A0A2I3LF87
uniprot id: A0A2I3M430
uniprot id: A0A2I3MHK2
uniprot id: A0A8I5R6V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9555:METTL6
gene id: 9555:METTL6
uniprot id: A0A096MSL2
uniprot id: A0A2I3MV50
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9555:LGALS3
gene id: 9555:LGALS3
uniprot id: A0A096NV76
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9555:ALDH3B1
gene id: 9555:ALDH3B1
uniprot id: A0A096MKW4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:MPC1
gene id: 9555:MPC1
uniprot id: A0A2I3NA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9555:NCAPH2
gene id: 9555:NCAPH2
uniprot id: A0A096NL50
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

9555:SLC25A29
gene id: 9555:SLC25A29
uniprot id: A0A096NJR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:NUMBL
gene id: 9555:NUMBL
uniprot id: A0A0A0MU57
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a role in the process of neurogenesis.

9555:ILKAP
gene id: 9555:ILKAP
uniprot id: A0A096N532
names: Similarity
messages: Belongs to the PP2C family.

9555:MC1R
gene id: 9555:MC1R
uniprot id: Q864J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.

9555:CBFB
gene id: 9555:CBFB
uniprot id: A0A096NJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9555:NR1H3
gene id: 9555:NR1H3
uniprot id: A0A096NGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9555:SUSD6
gene id: 9555:SUSD6
uniprot id: A0A096NVU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:FPR2
gene id: 9555:FPR2
uniprot id: A0A0A0MWP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:TACR1
gene id: 9555:TACR1
uniprot id: A0A096N5A2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9555:GRPR
gene id: 9555:GRPR
uniprot id: A0A096N446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:PLCG2
gene id: 9555:PLCG2
uniprot id: A0A096NBT6
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9555:ADRA1D
gene id: 9555:ADRA1D
uniprot id: A0A096NVC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9555:MYB
gene id: 9555:MYB
uniprot id: A0A096NDT6
names: Subcellular Location Annotation
messages: Nucleus

9555:EML4
gene id: 9555:EML4
uniprot id: A0A096MVX9
uniprot id: A0A2I3MBM1
uniprot id: A0A2I3N5P4
uniprot id: A0A8I5N2D5
uniprot id: A0A8I5RA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9555:IQCD
gene id: 9555:IQCD
uniprot id: A0A096N356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9555:DYNC1LI1
gene id: 9555:DYNC1LI1
uniprot id: A0A096N8Y5
uniprot id: A0A2I3LR59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9555:PPARGC1B
gene id: 9555:PPARGC1B
uniprot id: A0A096MPZ4
uniprot id: A0A2I3NHT5
names: Subcellular Location Annotation
messages: Nucleus

9555:UBL3
gene id: 9555:UBL3
uniprot id: A0A096MWS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:FABP1
gene id: 9555:FABP1
uniprot id: A0A2I3LPH8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9555:MARVELD2
gene id: 9555:MARVELD2
uniprot id: A0A096MKZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9555:LOC101021397
gene id: 9555:LOC101021397
uniprot id: A0A8I5NVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9555:IL23A
gene id: 9555:IL23A
uniprot id: A0A096NH07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9555:ZFPM2
gene id: 9555:ZFPM2
uniprot id: A0A2I3N9S4
uniprot id: A0A8I5MUL8
uniprot id: A0A8I5NGX5
uniprot id: A0A8I5R987
names: Subcellular Location Annotation
messages: Nucleus

9555:ZNRF4
gene id: 9555:ZNRF4
uniprot id: A0A8I5NU12
names: Subcellular Location Annotation
messages: Membrane

9555:KCTD11
gene id: 9555:KCTD11
uniprot id: A0A2I3MQP8
names: Subcellular Location Annotation
messages: Cell membrane

9555:GNB4
gene id: 9555:GNB4
uniprot id: A0A096N324
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9555:SLC25A31
gene id: 9555:SLC25A31
uniprot id: A0A096MUY6
uniprot id: A0A8I5QZZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9555:GABARAPL2
gene id: 9555:GABARAPL2
uniprot id: A0A096MVY1
names: Similarity
messages: Belongs to the ATG8 family.

9555:VEGFC
gene id: 9555:VEGFC
uniprot id: A0A8I5N9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9555:CD81
gene id: 9555:CD81
uniprot id: A0A096MQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9555:VPS25
gene id: 9555:VPS25
uniprot id: A0A2I3MUY2
names: Similarity
messages: Belongs to the VPS25 family.

9555:SLC25A35
gene id: 9555:SLC25A35
uniprot id: A0A2I3NGL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:TCP11L1
gene id: 9555:TCP11L1
uniprot id: A0A096NR17
names: Similarity
messages: Belongs to the TCP11 family.

9555:PACS2
gene id: 9555:PACS2
uniprot id: A0A096NK67
names: Similarity
messages: Belongs to the PACS family.

9555:NAPRT
gene id: 9555:NAPRT
uniprot id: A0A096NWT1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9555:GARS1
gene id: 9555:GARS1
uniprot id: A0A096NXT2
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9555:CLDN3
gene id: 9555:CLDN3
uniprot id: A0A096ML45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:GREM2
gene id: 9555:GREM2
uniprot id: A0A096MLY5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:TRMT44
gene id: 9555:TRMT44
uniprot id: A0A096NZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm

9555:SLC2A5
gene id: 9555:SLC2A5
uniprot id: A0A096N791
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: sarcolemma

9555:SLC25A30
gene id: 9555:SLC25A30
uniprot id: A0A096N7X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:PIGL
gene id: 9555:PIGL
uniprot id: A0A8I5P3L5
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9555:KLHL36
gene id: 9555:KLHL36
uniprot id: A0A096NPH1
names: Function
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9555:DNASE2B
gene id: 9555:DNASE2B
uniprot id: A0A096MYU6
names: Similarity
messages: Belongs to the DNase II family.

9555:HMGCS1
gene id: 9555:HMGCS1
uniprot id: A0A096NFC3
uniprot id: A0A8I5R2Z4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9555:DDX53
gene id: 9555:DDX53
uniprot id: A0A8I5NYB6
names: Similarity
messages: Belongs to the DEAD box helicase family.

9555:ZC3H12A
gene id: 9555:ZC3H12A
uniprot id: A0A096MTN7
names: Similarity
messages: Belongs to the ZC3H12 family.

9555:LOC108584558
gene id: 9555:LOC108584558
uniprot id: A0A8I5N8F7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9555:NCDN
gene id: 9555:NCDN
uniprot id: A0A096N7C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9555:PHF1
gene id: 9555:PHF1
uniprot id: A0A096NHI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9555:ST6GALNAC2
gene id: 9555:ST6GALNAC2
uniprot id: A0A096NT43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:RDH14
gene id: 9555:RDH14
uniprot id: A0A096NGX6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:FGD6
gene id: 9555:FGD6
uniprot id: A0A096MT41
names: Subcellular Location Annotation
messages: cytoskeleton

9555:NFS1
gene id: 9555:NFS1
uniprot id: B0CM84
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9555:MAATS1
gene id: 9555:MAATS1
uniprot id: A0A096MQN4
names: Similarity
messages: Belongs to the CFAP91 family.

9555:DYRK3
gene id: 9555:DYRK3
uniprot id: A0A096N2U1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9555:SELENBP1
gene id: 9555:SELENBP1
uniprot id: A0A096MWP7
uniprot id: A9X1A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9555:TTC39B
gene id: 9555:TTC39B
uniprot id: A0A096P1I2
uniprot id: A0A096P1I3
names: Similarity
messages: Belongs to the TTC39 family.

9555:B4GALT5
gene id: 9555:B4GALT5
uniprot id: A0A096NNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Membrane

9555:UTRN
gene id: 9555:UTRN
uniprot id: A0A096MU53
names: Subcellular Location Annotation
messages: cytoskeleton

9555:CD40
gene id: 9555:CD40
uniprot id: U5LKV0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:INA
gene id: 9555:INA
uniprot id: A0A096P6G7
names: Similarity
messages: Belongs to the intermediate filament family.

9555:PON2
gene id: 9555:PON2
uniprot id: A0A2I3LH95
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9555:CD46
gene id: 9555:CD46
uniprot id: A0A096NAP4
uniprot id: A0A2I3LWZ4
uniprot id: A0A2I3M7U9
uniprot id: A0A2I3MI60
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9555:BCKDK
gene id: 9555:BCKDK
uniprot id: A0A096NHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9555:TECR
gene id: 9555:TECR
uniprot id: A0A0A0MVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:LOC101008370
gene id: 9555:LOC101008370
uniprot id: A0A096NZY9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9555:MED14
gene id: 9555:MED14
uniprot id: A0A096N4X6
uniprot id: A0A2I3MKA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9555:SLC25A45
gene id: 9555:SLC25A45
uniprot id: A0A096N653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:ZNF274
gene id: 9555:ZNF274
uniprot id: A0A0A0MVX0
names: Subcellular Location Annotation
messages: Nucleus

9555:RIPPLY2
gene id: 9555:RIPPLY2
uniprot id: A0A8I5NFU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9555:PPP1R2C
gene id: 9555:PPP1R2C
uniprot id: A0A8I5R558
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9555:MOGAT2
gene id: 9555:MOGAT2
uniprot id: A0A096MYA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:DDIT3
gene id: 9555:DDIT3
uniprot id: A0A096NZ20
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9555:CBX7
gene id: 9555:CBX7
uniprot id: A0A096NK52
names: Subcellular Location Annotation
messages: Nucleus

9555:RPRD1B
gene id: 9555:RPRD1B
uniprot id: A0A096NXG4
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9555:DYNLT1
gene id: 9555:DYNLT1
uniprot id: A0A096NRM7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9555:TMEM135
gene id: 9555:TMEM135
uniprot id: A0A096NB85
uniprot id: A0A2I3MUJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9555:LPAR4
gene id: 9555:LPAR4
uniprot id: A0A096MLK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:DEFB121
gene id: 9555:DEFB121
uniprot id: A0A096NV14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:MOSPD1
gene id: 9555:MOSPD1
uniprot id: A0A2I3NC89
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9555:ARAP1
gene id: 9555:ARAP1
uniprot id: A0A096N7G3
names: Subcellular Location Annotation
messages: Cytoplasm

9555:BSCL2
gene id: 9555:BSCL2
uniprot id: A0A096MPF1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:MIS12
gene id: 9555:MIS12
uniprot id: A0A8I5MXW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9555:EFEMP1
gene id: 9555:EFEMP1
uniprot id: A0A096NP06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NDP
gene id: 9555:NDP
uniprot id: A0A8I5NXV3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:ATP6V0C
gene id: 9555:ATP6V0C
uniprot id: A0A096NL63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9555:VPS33B
gene id: 9555:VPS33B
uniprot id: A0A096NK56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9555:PDGFRB
gene id: 9555:PDGFRB
uniprot id: A0A096N5T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9555:FBLN7
gene id: 9555:FBLN7
uniprot id: A0A096NPD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ERO1A
gene id: 9555:ERO1A
uniprot id: A0A096NV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9555:RARS2
gene id: 9555:RARS2
uniprot id: A0A096N8U7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9555:TGFB3
gene id: 9555:TGFB3
uniprot id: A0A096NS60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9555:AKAP3
gene id: 9555:AKAP3
uniprot id: A0A096NP58
names: Similarity
messages: Belongs to the AKAP110 family.

9555:IPMK
gene id: 9555:IPMK
uniprot id: A0A096P582
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:MAP4K2
gene id: 9555:MAP4K2
uniprot id: B0CM66
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9555:LOC101008579
gene id: 9555:LOC101008579
uniprot id: G4XXN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9555:TSPYL6
gene id: 9555:TSPYL6
uniprot id: A0A8I5R062
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9555:THEMIS
gene id: 9555:THEMIS
uniprot id: A0A2I3M1C6
names: Similarity
messages: Belongs to the themis family.

9555:KRT10
gene id: 9555:KRT10
uniprot id: A0A096P5I5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:ATP2B4
gene id: 9555:ATP2B4
uniprot id: A0A096MSR2
uniprot id: A0A096MW85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:WDR82
gene id: 9555:WDR82
uniprot id: A0A096NSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9555:ASB17
gene id: 9555:ASB17
uniprot id: A0A096ML03
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9555:DOCK2
gene id: 9555:DOCK2
uniprot id: A0A096MQP9
names: Similarity
messages: Belongs to the DOCK family.

9555:CASTOR2
gene id: 9555:CASTOR2
uniprot id: A0A096MWE8
names: Similarity
messages: Belongs to the GATS family.

9555:FOXI1
gene id: 9555:FOXI1
uniprot id: A0A2I3MWV6
names: Subcellular Location Annotation
messages: Nucleus

9555:TRMT13
gene id: 9555:TRMT13
uniprot id: A0A096NCZ8
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9555:SERPINF2
gene id: 9555:SERPINF2
uniprot id: A0A096P2A7
names: Similarity
messages: Belongs to the serpin family.

9555:UGT2B42
gene id: 9555:UGT2B42
uniprot id: D2SMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:DSG3
gene id: 9555:DSG3
uniprot id: A0A096N202
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9555:ERI1
gene id: 9555:ERI1
uniprot id: A0A096MZD1
uniprot id: A0A8I5NIU5
names: Subcellular Location Annotation
messages: Cytoplasm

9555:TM6SF2
gene id: 9555:TM6SF2
uniprot id: A0A2I3MMH2
names: Subcellular Location Annotation
messages: Membrane

9555:CPA6
gene id: 9555:CPA6
uniprot id: A0A096MUH1
names: Similarity
messages: Belongs to the peptidase M14 family.

9555:OLR81
gene id: 9555:OLR81
uniprot id: A9L8W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:GALM
gene id: 9555:GALM
uniprot id: A0A096MYS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9555:SGK1
gene id: 9555:SGK1
uniprot id: A0A2I3M8F8
uniprot id: A0A2I3MLK8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:RCE1
gene id: 9555:RCE1
uniprot id: A0A096MSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:SERPINA4
gene id: 9555:SERPINA4
uniprot id: A0A096NJJ8
names: Similarity
messages: Belongs to the serpin family.

9555:CCL26
gene id: 9555:CCL26
uniprot id: A0A096NF44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:MRPL18
gene id: 9555:MRPL18
uniprot id: A0A096NZS4
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9555:LNPK
gene id: 9555:LNPK
uniprot id: A0A096NYJ6
uniprot id: A0A2I3LXI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9555:CRLS1
gene id: 9555:CRLS1
uniprot id: A0A096NVG1
uniprot id: A0A2I3LVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9555:TASOR
gene id: 9555:TASOR
uniprot id: A0A096NG80
names: Similarity
messages: Belongs to the TASOR family.

9555:NDUFC2
gene id: 9555:NDUFC2
uniprot id: A0A096MW31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9555:SAMD8
gene id: 9555:SAMD8
uniprot id: A0A096P4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9555:OLR145
gene id: 9555:OLR145
uniprot id: A9L8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:CWF19L1
gene id: 9555:CWF19L1
uniprot id: A0A2I3MAQ1
names: Similarity
messages: Belongs to the CWF19 family.

9555:RNASEH2A
gene id: 9555:RNASEH2A
uniprot id: A0A2I3N0D3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9555:JPH3
gene id: 9555:JPH3
uniprot id: A0A096N1V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9555:PLSCR3
gene id: 9555:PLSCR3
uniprot id: A0A096P2P5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9555:TARS2
gene id: 9555:TARS2
uniprot id: A0A096NG37
uniprot id: A0A2I3MSR8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9555:TMEM145
gene id: 9555:TMEM145
uniprot id: A0A0A0MV13
names: Subcellular Location Annotation
messages: Membrane

9555:COG1
gene id: 9555:COG1
uniprot id: A0A096NU52
names: Similarity
messages: Belongs to the COG1 family.

9555:ITPKC
gene id: 9555:ITPKC
uniprot id: A0A0A0MWV8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9555:ARF3
gene id: 9555:ARF3
uniprot id: A0A096NFY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9555:NHP2
gene id: 9555:NHP2
uniprot id: A0A096MLP0
uniprot id: A0A2I3LKX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9555:CLDN19
gene id: 9555:CLDN19
uniprot id: A0A2I3N7B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:CHRDL1
gene id: 9555:CHRDL1
uniprot id: A0A096NFG4
uniprot id: A0A2I3MPX9
names: Subcellular Location Annotation
messages: Secreted

9555:COLGALT1
gene id: 9555:COLGALT1
uniprot id: A0A0A0MW48
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9555:SPATA18
gene id: 9555:SPATA18
uniprot id: A0A096N2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9555:GPR183
gene id: 9555:GPR183
uniprot id: A0A096MVD0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:LRP5
gene id: 9555:LRP5
uniprot id: B5TRI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:ACAA1
gene id: 9555:ACAA1
uniprot id: A0A096NFA1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9555:LGALSL
gene id: 9555:LGALSL
uniprot id: A0A096P062
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.

9555:DUS4L
gene id: 9555:DUS4L
uniprot id: A0A096NWF6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9555:RPP14
gene id: 9555:RPP14
uniprot id: A0A096ML40
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9555:PLD2
gene id: 9555:PLD2
uniprot id: A0A096P2H2
names: Similarity
messages: Belongs to the phospholipase D family.

9555:UMOD
gene id: 9555:UMOD
uniprot id: A0A096NH77
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9555:ORMDL3
gene id: 9555:ORMDL3
uniprot id: A0A096P5D6
uniprot id: A0A8I5R0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9555:CUL1
gene id: 9555:CUL1
uniprot id: A0A096N574
names: Similarity
messages: Belongs to the cullin family.

9555:MED15
gene id: 9555:MED15
uniprot id: A0A096NS57
uniprot id: A0A2I3N6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:MYOG
gene id: 9555:MYOG
uniprot id: A0A096NXJ5
names: Subcellular Location Annotation
messages: Nucleus

9555:HMCES
gene id: 9555:HMCES
uniprot id: A0A096NPF5
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9555:PDK4
gene id: 9555:PDK4
uniprot id: A0A096NGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9555:ZNF768
gene id: 9555:ZNF768
uniprot id: A0A096NMG9
names: Subcellular Location Annotation
messages: Nucleus

9555:STAM2
gene id: 9555:STAM2
uniprot id: A0A096NXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9555:FBN2
gene id: 9555:FBN2
uniprot id: A0A096MRY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:SNX13
gene id: 9555:SNX13
uniprot id: A0A096NRZ5
uniprot id: A0A8I5N909
names: Similarity
messages: Belongs to the sorting nexin family.

9555:HYAL2
gene id: 9555:HYAL2
uniprot id: A0A096N541
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9555:LOC103878644
gene id: 9555:LOC103878644
uniprot id: A0A8I5NM80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:GCNT2
gene id: 9555:GCNT2
uniprot id: A0A2I3LEE4
uniprot id: A0A2I3NEY2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9555:CNNM3
gene id: 9555:CNNM3
uniprot id: A0A096NGS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9555:YWHAE
gene id: 9555:YWHAE
uniprot id: A0A096P296
names: Similarity
messages: Belongs to the 14-3-3 family.

9555:TAF15
gene id: 9555:TAF15
uniprot id: A0A096P3Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9555:MALSU1
gene id: 9555:MALSU1
uniprot id: A0A096NW03
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9555:RELL1
gene id: 9555:RELL1
uniprot id: A0A096NZM7
uniprot id: A0A8I5MV91
names: Similarity
messages: Belongs to the RELT family.

9555:CXCL14
gene id: 9555:CXCL14
uniprot id: A0A096NXY3
names: Subcellular Location Annotation
messages: Secreted

9555:KCNF1
gene id: 9555:KCNF1
uniprot id: A0A096N9H4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:SAR1A
gene id: 9555:SAR1A
uniprot id: A0A096P4X2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9555:NOX4
gene id: 9555:NOX4
uniprot id: A0A096MLX2
uniprot id: A0A2I3MKL1
uniprot id: A0A8I5N9S5
uniprot id: A0A8I5NCP7
names: Subcellular Location Annotation
messages: Membrane

9555:CBX5
gene id: 9555:CBX5
uniprot id: A0A2I3LLL9
names: Subcellular Location Annotation
messages: Nucleus

9555:INTS12
gene id: 9555:INTS12
uniprot id: A0A096NEV3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9555:GALNT18
gene id: 9555:GALNT18
uniprot id: A0A096NRX7
uniprot id: A0A8I5MWN7
uniprot id: A0A8I5NFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:KRT73
gene id: 9555:KRT73
uniprot id: A0A096NDU9
names: Similarity
messages: Belongs to the intermediate filament family.

9555:MGAT4A
gene id: 9555:MGAT4A
uniprot id: A0A096NVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:TIMM8B
gene id: 9555:TIMM8B
uniprot id: A0A2I3N145
uniprot id: A0A8I5N8Y1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9555:RNF2
gene id: 9555:RNF2
uniprot id: A0A096MYZ1
uniprot id: A0A2I3MUC7
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9555:NRXN2
gene id: 9555:NRXN2
uniprot id: B0CM62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CFAP97
gene id: 9555:CFAP97
uniprot id: A0A096N9Q8
names: Similarity
messages: Belongs to the CFAP97 family.

9555:NCAM1
gene id: 9555:NCAM1
uniprot id: A0A2I3LDU9
uniprot id: A0A2I3LMQ2
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

9555:SYNE4
gene id: 9555:SYNE4
uniprot id: A0A0A0MW24
names: Similarity
messages: Belongs to the nesprin family.

9555:SLC4A2
gene id: 9555:SLC4A2
uniprot id: A0A096N5Q5
uniprot id: A0A2I3LR53
uniprot id: A0A2I3M8T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane
messages: Plasma membrane anion exchange protein of wide distribution.

9555:IGF2BP2
gene id: 9555:IGF2BP2
uniprot id: A0A2I3LGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9555:HAO2
gene id: 9555:HAO2
uniprot id: A0A096N489
uniprot id: A0A2I3LSG5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9555:LOC101012887
gene id: 9555:LOC101012887
uniprot id: A0A096N1G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:OTULIN
gene id: 9555:OTULIN
uniprot id: A0A096NBB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9555:DBX1
gene id: 9555:DBX1
uniprot id: A0A2I3LQY1
names: Subcellular Location Annotation
messages: Nucleus

9555:LIMS2
gene id: 9555:LIMS2
uniprot id: A0A2I3LRQ6
uniprot id: A0A2I3M329
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9555:RPL3
gene id: 9555:RPL3
uniprot id: A0A096NK57
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9555:DYNLRB2
gene id: 9555:DYNLRB2
uniprot id: A0A096NAA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9555:ARCN1
gene id: 9555:ARCN1
uniprot id: A0A096NCP2
uniprot id: A0A2I3NC75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9555:POLR2H
gene id: 9555:POLR2H
uniprot id: A0A2I3NH56
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9555:PIH1D1
gene id: 9555:PIH1D1
uniprot id: A0A0A0MWL4
names: Similarity
messages: Belongs to the PIH1 family.

9555:TNN
gene id: 9555:TNN
uniprot id: A0A096N5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9555:CRYBG3
gene id: 9555:CRYBG3
uniprot id: A0A096NWE1
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9555:KCNK6
gene id: 9555:KCNK6
uniprot id: A0A0A0MW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:CD3D
gene id: 9555:CD3D
uniprot id: A0A2I3LRB2
uniprot id: A0A2I3MIM7
names: Subcellular Location Annotation
messages: Membrane

9555:C5H5orf63
gene id: 9555:C5H5orf63
uniprot id: A0A2I3LDN0
names: Similarity
messages: Belongs to the glutaredoxin family.

9555:ERCC1
gene id: 9555:ERCC1
uniprot id: A0A2I3NAT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9555:MARCHF9
gene id: 9555:MARCHF9
uniprot id: A0A096NH00
names: Subcellular Location Annotation
messages: Membrane

9555:GPC5
gene id: 9555:GPC5
uniprot id: A0A096MYU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9555:PLPPR2
gene id: 9555:PLPPR2
uniprot id: A0A2I3M7F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9555:MED10
gene id: 9555:MED10
uniprot id: A0A096MNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:MTF2
gene id: 9555:MTF2
uniprot id: A0A096NPN7
uniprot id: A0A2I3M2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9555:ATG4C
gene id: 9555:ATG4C
uniprot id: A0A096MWY4
uniprot id: A0A8I5N2D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9555:DSTN
gene id: 9555:DSTN
uniprot id: A0A2I3LIX1
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9555:PEBP4
gene id: 9555:PEBP4
uniprot id: A0A096N7E7
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9555:EXOSC3
gene id: 9555:EXOSC3
uniprot id: A0A096P146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9555:RHBDD1
gene id: 9555:RHBDD1
uniprot id: A0A096MQY3
uniprot id: A0A8I5N082
uniprot id: A0A8I5NE71
names: Subcellular Location Annotation
messages: Membrane

9555:GSDMC
gene id: 9555:GSDMC
uniprot id: A0A2I3MBG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9555:HIF1A
gene id: 9555:HIF1A
uniprot id: A0A096NVI7
uniprot id: A0A2I3M5E1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9555:SLC25A5
gene id: 9555:SLC25A5
uniprot id: A0A096MZH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9555:PRDM12
gene id: 9555:PRDM12
uniprot id: A0A096P0F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9555:TENT5B
gene id: 9555:TENT5B
uniprot id: A0A096MUR3
names: Similarity
messages: Belongs to the TENT family.

9555:LOC116268596
gene id: 9555:LOC116268596
uniprot id: A0A096NM70
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9555:SLC20A2
gene id: 9555:SLC20A2
uniprot id: A0A096NQS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9555:DDI2
gene id: 9555:DDI2
uniprot id: A0A096MWC1
names: Similarity
messages: Belongs to the DDI1 family.

9555:SYN3
gene id: 9555:SYN3
uniprot id: A9CB45
names: Similarity
messages: Belongs to the synapsin family.

9555:CACUL1
gene id: 9555:CACUL1
uniprot id: A0A096NTW6
names: Similarity
messages: Belongs to the cullin family.

9555:LAPTM5
gene id: 9555:LAPTM5
uniprot id: A0A096N9A2
uniprot id: A0A8I5NXX3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9555:ACBD5
gene id: 9555:ACBD5
uniprot id: A0A096P3V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9555:BMPR2
gene id: 9555:BMPR2
uniprot id: A0A096MZD4
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9555:CTSK
gene id: 9555:CTSK
uniprot id: A0A096NH43
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9555:EMC1
gene id: 9555:EMC1
uniprot id: A0A096NFA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9555:CTC1
gene id: 9555:CTC1
uniprot id: A0A096P2T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9555:ACTA1
gene id: 9555:ACTA1
uniprot id: A0A096N2Y2
names: Similarity
messages: Belongs to the actin family.

9555:CACNG1
gene id: 9555:CACNG1
uniprot id: A0A096NTY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9555:PTPRM
gene id: 9555:PTPRM
uniprot id: A0A096N2E3
uniprot id: A0A2I3LGJ3
uniprot id: A0A8I5NCP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9555:GPRC5A
gene id: 9555:GPRC5A
uniprot id: A0A096MP84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:YWHAG
gene id: 9555:YWHAG
uniprot id: A0A096NJN7
names: Similarity
messages: Belongs to the 14-3-3 family.

9555:TRIM47
gene id: 9555:TRIM47
uniprot id: A0A096NSZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9555:FXYD1
gene id: 9555:FXYD1
uniprot id: A0A0A0MUU3
names: Similarity
messages: Belongs to the FXYD family.

9555:GRID2
gene id: 9555:GRID2
uniprot id: A0A2I3LQV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9555:ANKH
gene id: 9555:ANKH
uniprot id: A0A096MYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9555:PPIE
gene id: 9555:PPIE
uniprot id: A0A096N9N0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9555:ARF6
gene id: 9555:ARF6
uniprot id: A0A096N6M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9555:ZNF449
gene id: 9555:ZNF449
uniprot id: A0A096NBG2
names: Subcellular Location Annotation
messages: Nucleus

9555:ZSCAN31
gene id: 9555:ZSCAN31
uniprot id: A0A096NLK9
names: Subcellular Location Annotation
messages: Nucleus

9555:EPHA4
gene id: 9555:EPHA4
uniprot id: A0A096MZK5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9555:CELF4
gene id: 9555:CELF4
uniprot id: A0A096MYV2
uniprot id: A0A2I3MJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9555:ZNF592
gene id: 9555:ZNF592
uniprot id: A0A096NN17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:RAB11FIP4
gene id: 9555:RAB11FIP4
uniprot id: A0A096P3P5
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9555:UNC5B
gene id: 9555:UNC5B
uniprot id: A0A096P4T9
uniprot id: A0A2I3NA49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9555:ZPBP
gene id: 9555:ZPBP
uniprot id: A0A8I5MVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9555:CA7
gene id: 9555:CA7
uniprot id: A0A096NJ93
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9555:MID1
gene id: 9555:MID1
uniprot id: A0A2I3M7X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: Nucleus
messages: cytoskeleton

9555:ALPL
gene id: 9555:ALPL
uniprot id: A0A096N206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9555:METTL8
gene id: 9555:METTL8
uniprot id: A0A096NZH5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9555:LOC101023020
gene id: 9555:LOC101023020
uniprot id: A0A096NRD9
names: Similarity
messages: Belongs to the HPF1 family.

9555:CRTC2
gene id: 9555:CRTC2
uniprot id: A0A096MQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9555:ACOD1
gene id: 9555:ACOD1
uniprot id: A0A096MSC9
names: Similarity
messages: Belongs to the PrpD family.

9555:RASGRP4
gene id: 9555:RASGRP4
uniprot id: A0A0A0MUX0
names: Similarity
messages: Belongs to the RASGRP family.

9555:SUPT4H1
gene id: 9555:SUPT4H1
uniprot id: A0A096P4U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9555:MEN1
gene id: 9555:MEN1
uniprot id: B0CM67
names: Subcellular Location Annotation
messages: Nucleus

9555:TRAP1
gene id: 9555:TRAP1
uniprot id: A0A096NLD3
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9555:UBIAD1
gene id: 9555:UBIAD1
uniprot id: A0A096NWY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9555:RPTOR
gene id: 9555:RPTOR
uniprot id: A0A096NTC6
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9555:SFXN5
gene id: 9555:SFXN5
uniprot id: A0A096N252
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9555:DYNC1I1
gene id: 9555:DYNC1I1
uniprot id: A0A096NDJ6
uniprot id: A0A2I3M795
uniprot id: A0A8I5N0H5
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9555:ZFP91
gene id: 9555:ZFP91
uniprot id: A0A096N0J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9555:SULT1B1
gene id: 9555:SULT1B1
uniprot id: A0A096N9E5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9555:ATP5PO
gene id: 9555:ATP5PO
uniprot id: A9CB05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9555:TANGO6
gene id: 9555:TANGO6
uniprot id: A0A096MNF5
names: Similarity
messages: Belongs to the Tango6 family.

9555:RHBDD2
gene id: 9555:RHBDD2
uniprot id: A0A096MVK2
names: Subcellular Location Annotation
messages: Membrane

9555:MS4A10
gene id: 9555:MS4A10
uniprot id: A0A2I3M8K6
names: Similarity
messages: Belongs to the MS4A family.

9555:MGAT4B
gene id: 9555:MGAT4B
uniprot id: A0A096MWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:UFM1
gene id: 9555:UFM1
uniprot id: A0A8I5R588
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9555:FREM3
gene id: 9555:FREM3
uniprot id: A0A096MR25
names: Similarity
messages: Belongs to the FRAS1 family.

9555:LOC108583710
gene id: 9555:LOC108583710
uniprot id: A0A096NE90
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9555:CHPF
gene id: 9555:CHPF
uniprot id: A0A096MV62
uniprot id: B0CM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9555:LDAH
gene id: 9555:LDAH
uniprot id: A0A096N270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9555:LOC101013819
gene id: 9555:LOC101013819
uniprot id: A0A2I3LZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9555:PPP4R3B
gene id: 9555:PPP4R3B
uniprot id: A0A096NP09
uniprot id: A0A2I3LF90
uniprot id: A0A2I3MML1
names: Similarity
messages: Belongs to the SMEK family.

9555:LOC101016903
gene id: 9555:LOC101016903
uniprot id: A0A096MZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9555:GART
gene id: 9555:GART
uniprot id: A0A096NE33
uniprot id: A9CB00
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9555:PLA2G3
gene id: 9555:PLA2G3
uniprot id: A0A096NJM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9555:CAMK2G
gene id: 9555:CAMK2G
uniprot id: A0A096P4K7
uniprot id: A0A2I3LKN4
uniprot id: A0A2I3N097
uniprot id: A0A2I3N8S0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9555:DNM2
gene id: 9555:DNM2
uniprot id: A0A2I3LFK3
uniprot id: A0A2I3MM57
uniprot id: A0A2I3MQ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9555:SERPINB2
gene id: 9555:SERPINB2
uniprot id: A9RA95
names: Similarity
messages: Belongs to the serpin family.

9555:NUBP2
gene id: 9555:NUBP2
uniprot id: A0A096NKX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9555:ITGAL
gene id: 9555:ITGAL
uniprot id: A0A2I3NE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9555:LOC101016309
gene id: 9555:LOC101016309
uniprot id: A0A096NM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9555:ALOX12B
gene id: 9555:ALOX12B
uniprot id: A0A096P2T3
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TWF1
gene id: 9555:TWF1
uniprot id: A0A096NE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9555:RP2
gene id: 9555:RP2
uniprot id: A0A096NXT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9555:CCNJ
gene id: 9555:CCNJ
uniprot id: A0A096P5T2
names: Similarity
messages: Belongs to the cyclin family.

9555:GORASP2
gene id: 9555:GORASP2
uniprot id: A0A096NZH2
uniprot id: A0A8I5P2F8
names: Similarity
messages: Belongs to the GORASP family.

9555:GMFG
gene id: 9555:GMFG
uniprot id: A0A2I3M1E3
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9555:MRPS18C
gene id: 9555:MRPS18C
uniprot id: A0A2I3NC38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9555:CD68
gene id: 9555:CD68
uniprot id: A0A096P2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9555:MOGS
gene id: 9555:MOGS
uniprot id: A0A096NR15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9555:LOC101006708
gene id: 9555:LOC101006708
uniprot id: A0A096N8A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:STEAP2
gene id: 9555:STEAP2
uniprot id: B0CM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9555:SNX20
gene id: 9555:SNX20
uniprot id: A0A096NI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9555:PSMD11
gene id: 9555:PSMD11
uniprot id: A0A096P3S8
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9555:BOP1
gene id: 9555:BOP1
uniprot id: A0A096N323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9555:CCL20
gene id: 9555:CCL20
uniprot id: A0A096N8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9555:EFNB2
gene id: 9555:EFNB2
uniprot id: A0A096NWS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:OTX2
gene id: 9555:OTX2
uniprot id: A0A096NVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9555:RSPO1
gene id: 9555:RSPO1
uniprot id: A0A096MU32
names: Similarity
messages: Belongs to the R-spondin family.

9555:STX7
gene id: 9555:STX7
uniprot id: A0A096N5A9
uniprot id: A0A8I5NUW0
names: Similarity
messages: Belongs to the syntaxin family.

9555:ITPK1
gene id: 9555:ITPK1
uniprot id: A0A096NJF4
names: Similarity
messages: Belongs to the ITPK1 family.

9555:CORT
gene id: 9555:CORT
uniprot id: A0A2I3MPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9555:BCAR1
gene id: 9555:BCAR1
uniprot id: A0A2I3LHH9
uniprot id: A0A2I3M2I1
uniprot id: A0A2I3NDS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9555:DCLRE1A
gene id: 9555:DCLRE1A
uniprot id: A0A096NBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9555:SYNGR2
gene id: 9555:SYNGR2
uniprot id: A0A096NT64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9555:PSMB11
gene id: 9555:PSMB11
uniprot id: A0A096MKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:LOC101001730
gene id: 9555:LOC101001730
uniprot id: A0A096NJ85
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9555:MRPL11
gene id: 9555:MRPL11
uniprot id: A0A2I3N4R9
uniprot id: A0A8I5NPG3
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9555:SCGB2A2
gene id: 9555:SCGB2A2
uniprot id: A0A2I3MIK8
names: Subcellular Location Annotation
messages: Secreted

9555:PTGDR
gene id: 9555:PTGDR
uniprot id: A0A096NV01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:ADAMTS19
gene id: 9555:ADAMTS19
uniprot id: A0A2I3MP46
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:PPP1R14A
gene id: 9555:PPP1R14A
uniprot id: A0A2I3M7M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9555:PISD
gene id: 9555:PISD
uniprot id: A0A096NJM9
uniprot id: A9CB35
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9555:OR52N4
gene id: 9555:OR52N4
uniprot id: A9L8V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:ATG16L1
gene id: 9555:ATG16L1
uniprot id: A0A096MYC3
uniprot id: A0A2I3LK84
uniprot id: A0A2I3LRY7
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9555:INHBC
gene id: 9555:INHBC
uniprot id: A0A096NAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9555:PPDPFL
gene id: 9555:PPDPFL
uniprot id: A0A096NPP3
names: Similarity
messages: Belongs to the PPDPF family.

9555:ND4
gene id: 9555:ND4
uniprot id: K9MUQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9555:RGS7BP
gene id: 9555:RGS7BP
uniprot id: A0A096MN36
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9555:ATP5MC2
gene id: 9555:ATP5MC2
uniprot id: A0A096MP80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9555:CFH
gene id: 9555:CFH
uniprot id: A0A2I3LLN3
uniprot id: A0A2I3LN58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ADTRP
gene id: 9555:ADTRP
uniprot id: A0A096NKY2
uniprot id: A0A2I3N3A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9555:FUZ
gene id: 9555:FUZ
uniprot id: A0A0A0MUE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9555:S1PR2
gene id: 9555:S1PR2
uniprot id: A0A0A0MWW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9555:PDP2
gene id: 9555:PDP2
uniprot id: A0A096NJ94
names: Similarity
messages: Belongs to the PP2C family.

9555:MON1B
gene id: 9555:MON1B
uniprot id: A0A2I3N5F2
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9555:BEST4
gene id: 9555:BEST4
uniprot id: A0A096N2C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9555:CD164
gene id: 9555:CD164
uniprot id: A0A2I3LIC2
uniprot id: A0A2I3M9N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9555:UGT2B15
gene id: 9555:UGT2B15
uniprot id: D2SML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:AQP4
gene id: 9555:AQP4
uniprot id: A0A096NGN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9555:CDX2
gene id: 9555:CDX2
uniprot id: A0A8I5R839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9555:PLA2G2D
gene id: 9555:PLA2G2D
uniprot id: A0A8I5NH21
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9555:PPP1R12B
gene id: 9555:PPP1R12B
uniprot id: A0A096NBH1
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9555:TMEFF1
gene id: 9555:TMEFF1
uniprot id: A0A096P109
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:MAN2A1
gene id: 9555:MAN2A1
uniprot id: A0A096N4V0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9555:HOXD1
gene id: 9555:HOXD1
uniprot id: A0A096N796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9555:CTSH
gene id: 9555:CTSH
uniprot id: A0A2I3MPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9555:FOLR3
gene id: 9555:FOLR3
uniprot id: A0A096MUB4
names: Similarity
messages: Belongs to the folate receptor family.

9555:CDC42EP3
gene id: 9555:CDC42EP3
uniprot id: A0A096MLW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9555:KDM4A
gene id: 9555:KDM4A
uniprot id: A0A096ML87
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9555:LZIC
gene id: 9555:LZIC
uniprot id: A0A096NA05
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9555:ZC3H14
gene id: 9555:ZC3H14
uniprot id: A0A096NW64
uniprot id: A0A096NW67
uniprot id: A0A2I3LWL0
uniprot id: A0A2I3MTZ0
uniprot id: A0A8I5R6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9555:APOC2
gene id: 9555:APOC2
uniprot id: A0A096P2H4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9555:MAN2A2
gene id: 9555:MAN2A2
uniprot id: A0A096NK76
uniprot id: A0A2I3MSV8
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9555:JPH2
gene id: 9555:JPH2
uniprot id: A0A096NXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9555:CLSPN
gene id: 9555:CLSPN
uniprot id: A0A096NXN6
names: Subcellular Location Annotation
messages: Nucleus

9555:STON1
gene id: 9555:STON1
uniprot id: A0A096NUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9555:RELL2
gene id: 9555:RELL2
uniprot id: A0A096NRL1
names: Similarity
messages: Belongs to the RELT family.

9555:VEGFB
gene id: 9555:VEGFB
uniprot id: A0A2I3LCN1
uniprot id: A0A2I3LL73
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9555:HMGB1
gene id: 9555:HMGB1
uniprot id: A9RA84
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B c…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by Glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9555:TGM2
gene id: 9555:TGM2
uniprot id: A0A096NXG3
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9555:GSKIP
gene id: 9555:GSKIP
uniprot id: A0A096NJN1
names: Similarity
messages: Belongs to the GSKIP family.

9555:UGT1A6
gene id: 9555:UGT1A6
uniprot id: Q20CL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9555:MOB3C
gene id: 9555:MOB3C
uniprot id: A0A096MZF7
names: Similarity
messages: Belongs to the MOB1/phocein family.

9555:CCNT1
gene id: 9555:CCNT1
uniprot id: A0A096N2G7
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9555:ALDH1B1
gene id: 9555:ALDH1B1
uniprot id: A0A2I3M7C5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:EDEM1
gene id: 9555:EDEM1
uniprot id: A0A096N098
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9555:CCT7
gene id: 9555:CCT7
uniprot id: A0A096MV48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9555:LOC101010089
gene id: 9555:LOC101010089
uniprot id: A0A8I5NK31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:ME1
gene id: 9555:ME1
uniprot id: A0A096NUI3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9555:ATP2C2
gene id: 9555:ATP2C2
uniprot id: A0A2I3LM03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:MET
gene id: 9555:MET
uniprot id: A0M8R7
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9555:CNDP1
gene id: 9555:CNDP1
uniprot id: A0A096N7T7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9555:CDO1
gene id: 9555:CDO1
uniprot id: A0A096MZR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9555:PMM1
gene id: 9555:PMM1
uniprot id: A0A8I5NNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9555:SUB1
gene id: 9555:SUB1
uniprot id: A0A096N701
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9555:ADCY8
gene id: 9555:ADCY8
uniprot id: A0A096N068
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9555:ATG2A
gene id: 9555:ATG2A
uniprot id: B0CM70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9555:UBE2S
gene id: 9555:UBE2S
uniprot id: A0A8I5N782
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:EWSR1
gene id: 9555:EWSR1
uniprot id: A0A096NJD3
uniprot id: A0A2I3MFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9555:BCAP29
gene id: 9555:BCAP29
uniprot id: A0A096NF84
uniprot id: A0A2I3MV91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9555:EVA1B
gene id: 9555:EVA1B
uniprot id: A0A096N3D7
names: Similarity
messages: Belongs to the EVA1 family.

9555:PECR
gene id: 9555:PECR
uniprot id: A0A096MUY9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:SPNS3
gene id: 9555:SPNS3
uniprot id: A0A096P2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9555:SNX4
gene id: 9555:SNX4
uniprot id: A0A096MZ19
names: Similarity
messages: Belongs to the sorting nexin family.

9555:FUNDC1
gene id: 9555:FUNDC1
uniprot id: A0A096NC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9555:EIF4A2
gene id: 9555:EIF4A2
uniprot id: A0A096MMP1
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9555:TENT5D
gene id: 9555:TENT5D
uniprot id: A0A8I5R5N4
names: Similarity
messages: Belongs to the TENT family.

9555:FOXA3
gene id: 9555:FOXA3
uniprot id: A0A2I3NEP0
names: Subcellular Location Annotation
messages: Nucleus

9555:LOC101024278
gene id: 9555:LOC101024278
uniprot id: A0A2I3M899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9555:ING4
gene id: 9555:ING4
uniprot id: A0A096NS16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9555:GALNTL5
gene id: 9555:GALNTL5
uniprot id: A0A096N9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9555:FAM83F
gene id: 9555:FAM83F
uniprot id: A0A096NK74
names: Similarity
messages: Belongs to the FAM83 family.

9555:KIF2B
gene id: 9555:KIF2B
uniprot id: A0A8I5QZY4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:FAM174A
gene id: 9555:FAM174A
uniprot id: A0A096N9N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9555:SLITRK4
gene id: 9555:SLITRK4
uniprot id: A0A096MW92
names: Similarity
messages: Belongs to the SLITRK family.

9555:HIGD1B
gene id: 9555:HIGD1B
uniprot id: A0A8I5N5E6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9555:PLA2G15
gene id: 9555:PLA2G15
uniprot id: A0A096NZP4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9555:ITGB2
gene id: 9555:ITGB2
uniprot id: A0A2I3MWF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9555:CTSS
gene id: 9555:CTSS
uniprot id: A0A096NFN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9555:ZC3HC1
gene id: 9555:ZC3HC1
uniprot id: A0A2I3M4C0
names: Subcellular Location Annotation
messages: Nucleus

9555:HOXA2
gene id: 9555:HOXA2
uniprot id: A9L937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9555:XIRP1
gene id: 9555:XIRP1
uniprot id: A0A096NA03
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9555:DHX9
gene id: 9555:DHX9
uniprot id: A0A096NWR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9555:G6PC3
gene id: 9555:G6PC3
uniprot id: A0A096P5Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9555:PIGC
gene id: 9555:PIGC
uniprot id: A0A096N0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9555:TUBE1
gene id: 9555:TUBE1
uniprot id: A0A096MVT5
names: Similarity
messages: Belongs to the tubulin family.

9555:IDH3B
gene id: 9555:IDH3B
uniprot id: A0A096NV81
uniprot id: A0A2I3MGS8
uniprot id: A0A2I3MNR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9555:CUTC
gene id: 9555:CUTC
uniprot id: A0A096P658
names: Similarity
messages: Belongs to the CutC family.

9555:ASIP
gene id: 9555:ASIP
uniprot id: A1YL70
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9555:GRK7
gene id: 9555:GRK7
uniprot id: A0A096N8R4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9555:LOC101003969
gene id: 9555:LOC101003969
uniprot id: A0A096NB54
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:VPS37B
gene id: 9555:VPS37B
uniprot id: A0A096N561
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:RAB38
gene id: 9555:RAB38
uniprot id: A0A096MNA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9555:TM4SF4
gene id: 9555:TM4SF4
uniprot id: A0A096MSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9555:SPIN4
gene id: 9555:SPIN4
uniprot id: A0A096NCX5
names: Similarity
messages: Belongs to the SPIN/STSY family.

9555:CS
gene id: 9555:CS
uniprot id: A0A096NH04
uniprot id: A0A2I3LP12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9555:LOC101018547
gene id: 9555:LOC101018547
uniprot id: A0A8I5NLF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:LCK
gene id: 9555:LCK
uniprot id: A0A096N492
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9555:TPR
gene id: 9555:TPR
uniprot id: A0A096NBL2
names: Similarity
messages: Belongs to the TPR family.

9555:KCNC2
gene id: 9555:KCNC2
uniprot id: A0A2I3LCY1
uniprot id: A0A2I3LJN5
uniprot id: A0A2I3LLY5
uniprot id: A0A2I3M2X2
uniprot id: A0A2I3M541
uniprot id: A0A2I3NB78
uniprot id: A0A8I5N0C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:MTURN
gene id: 9555:MTURN
uniprot id: A0A2I3MSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9555:SMU1
gene id: 9555:SMU1
uniprot id: A0A096P1D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9555:ADSS2
gene id: 9555:ADSS2
uniprot id: A0A096N1Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9555:CCHCR1
gene id: 9555:CCHCR1
uniprot id: A0A2I3NEN9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9555:NGRN
gene id: 9555:NGRN
uniprot id: A0A096NNA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9555:EML3
gene id: 9555:EML3
uniprot id: A0A096NPF4
names: Subcellular Location Annotation
messages: cytoskeleton

9555:CORO2A
gene id: 9555:CORO2A
uniprot id: A0A096P127
names: Similarity
messages: Belongs to the WD repeat coronin family.

9555:MVB12A
gene id: 9555:MVB12A
uniprot id: A0A2I3MTA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:C4BPB
gene id: 9555:C4BPB
uniprot id: A0A2I3MB60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:NME3
gene id: 9555:NME3
uniprot id: A0A096NKW8
names: Similarity
messages: Belongs to the NDK family.

9555:TMED7
gene id: 9555:TMED7
uniprot id: A0A8I5MUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9555:WASHC1
gene id: 9555:WASHC1
uniprot id: A0A096MNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9555:TCL1B
gene id: 9555:TCL1B
uniprot id: A0A096NJL5
names: Similarity
messages: Belongs to the TCL1 family.

9555:SLC39A11
gene id: 9555:SLC39A11
uniprot id: A0A096NU49
names: Subcellular Location Annotation
messages: Membrane

9555:VARS2
gene id: 9555:VARS2
uniprot id: A0A2I3MA27
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9555:LOC103882072
gene id: 9555:LOC103882072
uniprot id: A0A8I5QZI4
names: Similarity
messages: Belongs to the actin family.

9555:SLC52A3
gene id: 9555:SLC52A3
uniprot id: A0A8I5N8K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9555:GPM6A
gene id: 9555:GPM6A
uniprot id: A0A096N533
uniprot id: A0A8I5MVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9555:SLC24A4
gene id: 9555:SLC24A4
uniprot id: A0A096NJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9555:HSD17B7
gene id: 9555:HSD17B7
uniprot id: A0A096NCZ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9555:ANKLE2
gene id: 9555:ANKLE2
uniprot id: A0A096MQR0
names: Similarity
messages: Belongs to the ANKLE2 family.

9555:MUC13
gene id: 9555:MUC13
uniprot id: A0A096NDS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:RALYL
gene id: 9555:RALYL
uniprot id: A0A2I3MLH1
uniprot id: A0A2I3NII3
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9555:GRM5
gene id: 9555:GRM5
uniprot id: A0A096MW30
uniprot id: A0A2I3NHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9555:ACAD8
gene id: 9555:ACAD8
uniprot id: A0A096ML57
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9555:LOC100999278
gene id: 9555:LOC100999278
uniprot id: A0A8I5NMF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:CLCN7
gene id: 9555:CLCN7
uniprot id: A0A096NKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9555:GABRQ
gene id: 9555:GABRQ
uniprot id: A0A096NQE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:LOC101000271
gene id: 9555:LOC101000271
uniprot id: A0A096NHZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9555:MAGI3
gene id: 9555:MAGI3
uniprot id: A0A096N7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9555:RPL39L
gene id: 9555:RPL39L
uniprot id: A0A8I5P2H5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9555:PPM1L
gene id: 9555:PPM1L
uniprot id: A0A2I3M9Z5
names: Similarity
messages: Belongs to the PP2C family.

9555:DNPH1
gene id: 9555:DNPH1
uniprot id: A0A096NIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9555:MMP14
gene id: 9555:MMP14
uniprot id: A0A096NSD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

9555:PPIH
gene id: 9555:PPIH
uniprot id: A0A096MU77
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9555:COL4A2
gene id: 9555:COL4A2
uniprot id: A0A096MN15
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9555:SERINC1
gene id: 9555:SERINC1
uniprot id: A0A096N5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9555:PSIP1
gene id: 9555:PSIP1
uniprot id: A0A096P1I0
uniprot id: A0A2I3LU29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9555:ILVBL
gene id: 9555:ILVBL
uniprot id: A0A0A0MW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9555:PCNX4
gene id: 9555:PCNX4
uniprot id: A0A096NVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9555:LHFPL2
gene id: 9555:LHFPL2
uniprot id: A0A096NCI1
names: Subcellular Location Annotation
messages: Membrane

9555:OSBPL2
gene id: 9555:OSBPL2
uniprot id: A0A096NNC7
names: Similarity
messages: Belongs to the OSBP family.

9555:UBE2G1
gene id: 9555:UBE2G1
uniprot id: A0A096P2F5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:PSMD7
gene id: 9555:PSMD7
uniprot id: A0A096MWU8
names: Similarity
messages: Belongs to the peptidase M67A family.

9555:NDUFB4
gene id: 9555:NDUFB4
uniprot id: A0A096NXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:SHROOM1
gene id: 9555:SHROOM1
uniprot id: A0A096MSB5
uniprot id: A9CB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9555:ACAT1
gene id: 9555:ACAT1
uniprot id: A0A096MZB0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9555:PHTF1
gene id: 9555:PHTF1
uniprot id: A0A096P021
uniprot id: A0A2I3LUF0
names: Subcellular Location Annotation
messages: Membrane

9555:HDAC3
gene id: 9555:HDAC3
uniprot id: A0A096MPL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9555:LOC108585455
gene id: 9555:LOC108585455
uniprot id: A0A2I3LZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9555:TMEM163
gene id: 9555:TMEM163
uniprot id: A0A096NDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

9555:FGF3
gene id: 9555:FGF3
uniprot id: A0A096NXI3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9555:SLC16A3
gene id: 9555:SLC16A3
uniprot id: A0A096NTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9555:SYNPR
gene id: 9555:SYNPR
uniprot id: A0A096NBR3
uniprot id: A0A2I3LQ20
uniprot id: A0A2I3MHF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9555:SLC25A2
gene id: 9555:SLC25A2
uniprot id: A0A096NC50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9555:SCML4
gene id: 9555:SCML4
uniprot id: A0A096NR75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9555:PRKCE
gene id: 9555:PRKCE
uniprot id: A0A8I5NUI2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9555:GAREM2
gene id: 9555:GAREM2
uniprot id: A0A096NSG4
names: Similarity
messages: Belongs to the GAREM family.

9555:EIF3K
gene id: 9555:EIF3K
uniprot id: A0A0A0MUQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9555:LPIN3
gene id: 9555:LPIN3
uniprot id: A0A096NXD3
names: Similarity
messages: Belongs to the lipin family.

9555:ZDHHC18
gene id: 9555:ZDHHC18
uniprot id: A0A8I5ND44
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:CCKAR
gene id: 9555:CCKAR
uniprot id: A0A096NZL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9555:RNASE9
gene id: 9555:RNASE9
uniprot id: Q863J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.
messages: Secreted

9555:RXRB
gene id: 9555:RXRB
uniprot id: A0A2I3LM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9555:TMEM178B
gene id: 9555:TMEM178B
uniprot id: A0A2I3MYC7
names: Similarity
messages: Belongs to the TMEM178 family.

9555:LOC101021945
gene id: 9555:LOC101021945
uniprot id: A0A096N7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:AHCYL1
gene id: 9555:AHCYL1
uniprot id: A0A096N3R6
uniprot id: A0A2I3M6A6
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9555:FZD5
gene id: 9555:FZD5
uniprot id: A0A096N985
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:IL7
gene id: 9555:IL7
uniprot id: A0A096N2Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

9555:DNMT3A
gene id: 9555:DNMT3A
uniprot id: A0A096MNF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9555:LOC101015460
gene id: 9555:LOC101015460
uniprot id: A0A096N461
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9555:BEST2
gene id: 9555:BEST2
uniprot id: A0A0A0MV62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9555:SEC24C
gene id: 9555:SEC24C
uniprot id: A0A096P4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9555:TCTEX1D1
gene id: 9555:TCTEX1D1
uniprot id: A0A096MPQ7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9555:RPS19BP1
gene id: 9555:RPS19BP1
uniprot id: A0A096NK65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9555:KCTD14
gene id: 9555:KCTD14
uniprot id: A0A2I3MVT8
names: Subcellular Location Annotation
messages: Cell membrane

9555:MINPP1
gene id: 9555:MINPP1
uniprot id: A0A096P5A5
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9555:TIMM8A
gene id: 9555:TIMM8A
uniprot id: A0A8I5N1Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9555:ARPC2
gene id: 9555:ARPC2
uniprot id: A0A096NGP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9555:VILL
gene id: 9555:VILL
uniprot id: A0A096NAV5
names: Similarity
messages: Belongs to the villin/gelsolin family.

9555:KIF12
gene id: 9555:KIF12
uniprot id: A0A096P0T1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9555:TSPYL5
gene id: 9555:TSPYL5
uniprot id: A0A096N364
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9555:SLC16A14
gene id: 9555:SLC16A14
uniprot id: A0A096MR26
names: Subcellular Location Annotation
messages: Membrane

9555:NDUFAF1
gene id: 9555:NDUFAF1
uniprot id: A0A096NTM8
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9555:ZDHHC9
gene id: 9555:ZDHHC9
uniprot id: A0A096N7C8
uniprot id: A0A8I5NY33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9555:HPCAL4
gene id: 9555:HPCAL4
uniprot id: A0A096N6T1
uniprot id: A0A096N8T0
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9555:MEAF6
gene id: 9555:MEAF6
uniprot id: A0A096MU84
uniprot id: A0A2I3MD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9555:VPS37A
gene id: 9555:VPS37A
uniprot id: A0A096MZ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9555:TAF9
gene id: 9555:TAF9
uniprot id: A0A8I5NA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9555:EPOR
gene id: 9555:EPOR
uniprot id: A0A0A0MVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Forms homodimers on EPO stimulation.
messages: Membrane
messages: Receptor for erythropoietin.

9555:ARRDC2
gene id: 9555:ARRDC2
uniprot id: A0A0A0MWG7
names: Similarity
messages: Belongs to the arrestin family.

9555:GALNT10
gene id: 9555:GALNT10
uniprot id: A0A096MKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:PNMT
gene id: 9555:PNMT
uniprot id: A0A096P5C5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9555:AK5
gene id: 9555:AK5
uniprot id: A0A096N7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9555:ORMDL2
gene id: 9555:ORMDL2
uniprot id: A0A096P5D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9555:ARL3
gene id: 9555:ARL3
uniprot id: A0A2I3NGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9555:FGF11
gene id: 9555:FGF11
uniprot id: A0A096P2Q2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9555:SPP1
gene id: 9555:SPP1
uniprot id: A0A096N0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9555:SEMG1
gene id: 9555:SEMG1
uniprot id: A4K2M8
names: Similarity
messages: Belongs to the semenogelin family.

9555:SMAD5
gene id: 9555:SMAD5
uniprot id: A0A096MMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9555:CD200
gene id: 9555:CD200
uniprot id: A0A096NFE5
uniprot id: A0A8I5N7M5
uniprot id: A0A8I5NRG8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:VPS11
gene id: 9555:VPS11
uniprot id: A0A096NAD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9555:MMRN1
gene id: 9555:MMRN1
uniprot id: A0A096MXC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PEX16
gene id: 9555:PEX16
uniprot id: A0A096NBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9555:MAGOHB
gene id: 9555:MAGOHB
uniprot id: A0A2I3LDE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9555:PHB
gene id: 9555:PHB
uniprot id: A0A096P453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9555:UPF3B
gene id: 9555:UPF3B
uniprot id: A0A096NAQ0
uniprot id: A0A2I3M4B7
names: Similarity
messages: Belongs to the RENT3 family.

9555:PAGE4
gene id: 9555:PAGE4
uniprot id: A0A096NB63
uniprot id: A0A8I5NGB7
names: Similarity
messages: Belongs to the GAGE family.

9555:NEDD4L
gene id: 9555:NEDD4L
uniprot id: A0A096MRT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ALDH4A1
gene id: 9555:ALDH4A1
uniprot id: A0A2I3MQP5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:HCAR1
gene id: 9555:HCAR1
uniprot id: A0A096ML30
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:TIMELESS
gene id: 9555:TIMELESS
uniprot id: A0A096NH10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9555:SLC10A7
gene id: 9555:SLC10A7
uniprot id: A0A096N629
uniprot id: A0A2I3LHM4
uniprot id: A0A2I3NCP3
uniprot id: A0A8I5P0A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9555:CHMP1A
gene id: 9555:CHMP1A
uniprot id: A0A096NFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9555:C7
gene id: 9555:C7
uniprot id: A0A096NBN3
uniprot id: A0A8I5R1R3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9555:RAB3A
gene id: 9555:RAB3A
uniprot id: A0A0A0MWG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9555:HOXB1
gene id: 9555:HOXB1
uniprot id: A0A096P422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9555:WNT4
gene id: 9555:WNT4
uniprot id: A0A096MUY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:ARSJ
gene id: 9555:ARSJ
uniprot id: A0A096MYQ7
uniprot id: A0A2I3LHU2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9555:TBC1D23
gene id: 9555:TBC1D23
uniprot id: A0A096MV73
uniprot id: A0A2I3MPR1
uniprot id: A0A2I3MR56
names: Subcellular Location Annotation
messages: trans-Golgi network

9555:LOC101009903
gene id: 9555:LOC101009903
uniprot id: A0A096NG11
names: Similarity
messages: Belongs to the cytochrome P450 family.

9555:BBS2
gene id: 9555:BBS2
uniprot id: A0A096NII1
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9555:LAMTOR2
gene id: 9555:LAMTOR2
uniprot id: A0A2I3NIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9555:IL1RL2
gene id: 9555:IL1RL2
uniprot id: A0A096NXS6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9555:ATP6V1B1
gene id: 9555:ATP6V1B1
uniprot id: A0A096N0R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9555:STMN2
gene id: 9555:STMN2
uniprot id: A0A2I3M6E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

9555:LOC103876796
gene id: 9555:LOC103876796
uniprot id: A0A096MNL1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9555:TYROBP
gene id: 9555:TYROBP
uniprot id: A0A0A0MUS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9555:PIK3IP1
gene id: 9555:PIK3IP1
uniprot id: A0A2I3MM51
uniprot id: A0A2I3MU72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LGR5
gene id: 9555:LGR5
uniprot id: A0A096MVL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9555:TMEM86A
gene id: 9555:TMEM86A
uniprot id: A0A8I5NJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9555:DOLPP1
gene id: 9555:DOLPP1
uniprot id: B0CM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

9555:MRGBP
gene id: 9555:MRGBP
uniprot id: A0A8I5R0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

9555:ZSCAN9
gene id: 9555:ZSCAN9
uniprot id: A0A096NLJ9
uniprot id: A0A096NLK0
names: Subcellular Location Annotation
messages: Nucleus

9555:LOC101016144
gene id: 9555:LOC101016144
uniprot id: A0A8I5NHQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:LOC101009425
gene id: 9555:LOC101009425
uniprot id: A0A096NS15
names: Similarity
messages: Belongs to the cytochrome b5 family.

9555:AGAP2
gene id: 9555:AGAP2
uniprot id: A0A2I3M2D4
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9555:PHLDA3
gene id: 9555:PHLDA3
uniprot id: A0A096MLM2
names: Subcellular Location Annotation
messages: Cytoplasm

9555:CADM4
gene id: 9555:CADM4
uniprot id: A0A0A0MWN3
names: Similarity
messages: Belongs to the nectin family.

9555:MEGF9
gene id: 9555:MEGF9
uniprot id: A0A096P0R0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PSMB10
gene id: 9555:PSMB10
uniprot id: A0A096NY91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9555:TMEM168
gene id: 9555:TMEM168
uniprot id: A0A096NEZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9555:KREMEN2
gene id: 9555:KREMEN2
uniprot id: A0A096NL87
uniprot id: A0A2I3MFA6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9555:XYLB
gene id: 9555:XYLB
uniprot id: A0A096NFA2
uniprot id: A0A8I5N903
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9555:CDC42EP2
gene id: 9555:CDC42EP2
uniprot id: A0A096ML12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9555:RRAD
gene id: 9555:RRAD
uniprot id: A0A096NJA0
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9555:RTRAF
gene id: 9555:RTRAF
uniprot id: A0A8I5R6Y5
names: Similarity
messages: Belongs to the RTRAF family.

9555:CTH
gene id: 9555:CTH
uniprot id: A0A2I3MWR0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9555:NSUN3
gene id: 9555:NSUN3
uniprot id: A0A096N0A7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9555:FGF16
gene id: 9555:FGF16
uniprot id: A0A096MT75
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9555:ZSCAN29
gene id: 9555:ZSCAN29
uniprot id: A0A096NSP3
uniprot id: A9X1B1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:EMP3
gene id: 9555:EMP3
uniprot id: A0A0A0MU61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9555:ORMDL1
gene id: 9555:ORMDL1
uniprot id: A0A096NBS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9555:SMUG1
gene id: 9555:SMUG1
uniprot id: A0A096MT05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9555:FANCC
gene id: 9555:FANCC
uniprot id: A0A096P263
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9555:TACR2
gene id: 9555:TACR2
uniprot id: A0A2I3N7E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9555:MAPKAPK3
gene id: 9555:MAPKAPK3
uniprot id: A0A096N543
uniprot id: A0A8I5MXH4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:GGPS1
gene id: 9555:GGPS1
uniprot id: A0A096NPM7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9555:TNFAIP8L2
gene id: 9555:TNFAIP8L2
uniprot id: A9X192
names: Domain
names: Function
names: Similarity
messages: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
messages: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
messages: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).

9555:IL2
gene id: 9555:IL2
uniprot id: Q865Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9555:SLC16A12
gene id: 9555:SLC16A12
uniprot id: A0A096P5F3
names: Subcellular Location Annotation
messages: Membrane

9555:CLSTN3
gene id: 9555:CLSTN3
uniprot id: A0A096MRF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9555:WNT6
gene id: 9555:WNT6
uniprot id: A0A096NCS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9555:GHR
gene id: 9555:GHR
uniprot id: A0A2I3NFX2
uniprot id: A0A2I3NG05
uniprot id: Q9XSZ1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9555:GTPBP4
gene id: 9555:GTPBP4
uniprot id: A0A096P371
uniprot id: A0A2I3N180
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9555:AVPR1B
gene id: 9555:AVPR1B
uniprot id: A0A096NS18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9555:MARF1
gene id: 9555:MARF1
uniprot id: A0A096NLV4
names: Subcellular Location Annotation
messages: Peroxisome

9555:CX3CR1
gene id: 9555:CX3CR1
uniprot id: A0A096MKX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9555:ZNF703
gene id: 9555:ZNF703
uniprot id: A0A096MYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9555:HOXD13
gene id: 9555:HOXD13
uniprot id: A0A096NPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9555:TBPL1
gene id: 9555:TBPL1
uniprot id: A0A096MXD7
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9555:MAP2K5
gene id: 9555:MAP2K5
uniprot id: A0A096NMG1
uniprot id: A0A2I3MFV9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:LOC101021583
gene id: 9555:LOC101021583
uniprot id: A0A096NFZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:HBG2
gene id: 9555:HBG2
uniprot id: A9L8X9
names: Similarity
messages: Belongs to the globin family.

9555:NLRP4
gene id: 9555:NLRP4
uniprot id: A0A0A0MVW4
names: Similarity
messages: Belongs to the NLRP family.

9555:SEC24D
gene id: 9555:SEC24D
uniprot id: A0A096MXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9555:GK2
gene id: 9555:GK2
uniprot id: A0A096N0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9555:MINDY4
gene id: 9555:MINDY4
uniprot id: A0A096P078
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9555:GUCY2D
gene id: 9555:GUCY2D
uniprot id: A0A096P2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9555:ADAMTS8
gene id: 9555:ADAMTS8
uniprot id: A0A096N1C0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9555:SLC26A6
gene id: 9555:SLC26A6
uniprot id: A0A096MYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane

9555:ELP4
gene id: 9555:ELP4
uniprot id: A0A096N2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9555:OVOL2
gene id: 9555:OVOL2
uniprot id: A0A096NVN1
names: Subcellular Location Annotation
messages: Nucleus

9555:ZC3H12D
gene id: 9555:ZC3H12D
uniprot id: A0A2I3LFI3
names: Similarity
messages: Belongs to the ZC3H12 family.

9555:AMIGO2
gene id: 9555:AMIGO2
uniprot id: A0A096NCW5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9555:CCSER1
gene id: 9555:CCSER1
uniprot id: A0A2I3LZQ4
names: Similarity
messages: Belongs to the CCSER family.

9555:PDRG1
gene id: 9555:PDRG1
uniprot id: A0A096NUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9555:CSK
gene id: 9555:CSK
uniprot id: A0A096NMR6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:PAXBP1
gene id: 9555:PAXBP1
uniprot id: A9CAZ1
names: Similarity
messages: Belongs to the GCF family.

9555:OVOL1
gene id: 9555:OVOL1
uniprot id: A0A096NCN0
names: Subcellular Location Annotation
messages: Nucleus

9555:SEC13
gene id: 9555:SEC13
uniprot id: A0A2I3N7G8
uniprot id: A0A2I3NB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9555:GAL3ST3
gene id: 9555:GAL3ST3
uniprot id: A0A096MQE7
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9555:SLC1A4
gene id: 9555:SLC1A4
uniprot id: A0A096P070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9555:EHD2
gene id: 9555:EHD2
uniprot id: A0A0A0MVW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9555:GBA2
gene id: 9555:GBA2
uniprot id: A0A096P172
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9555:KIN
gene id: 9555:KIN
uniprot id: A0A096P3D6
names: Similarity
messages: Belongs to the KIN17 family.

9555:RPN1
gene id: 9555:RPN1
uniprot id: A0A096MPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9555:IMPAD1
gene id: 9555:IMPAD1
uniprot id: A0A096N0F5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9555:UBE2R2
gene id: 9555:UBE2R2
uniprot id: A0A096P1B9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:SLC8A2
gene id: 9555:SLC8A2
uniprot id: A0A0A0MXD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9555:GRB2
gene id: 9555:GRB2
uniprot id: A0A096NSU8
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9555:MMP11
gene id: 9555:MMP11
uniprot id: A0A096NTK6
names: Similarity
messages: Belongs to the peptidase M10A family.

9555:RBP1
gene id: 9555:RBP1
uniprot id: A0A2I3LFI2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:SLC7A3
gene id: 9555:SLC7A3
uniprot id: A0A096N745
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9555:MTFR2
gene id: 9555:MTFR2
uniprot id: A0A096NQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9555:VPS52
gene id: 9555:VPS52
uniprot id: A0A096NHH0
names: Similarity
messages: Belongs to the VPS52 family.

9555:SYNDIG1
gene id: 9555:SYNDIG1
uniprot id: A0A8I5R9I9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9555:BCL2
gene id: 9555:BCL2
uniprot id: A0A096MPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9555:RELT
gene id: 9555:RELT
uniprot id: A0A096MY58
names: Similarity
messages: Belongs to the RELT family.

9555:CLIC4
gene id: 9555:CLIC4
uniprot id: A0A096NDH5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9555:KCNH3
gene id: 9555:KCNH3
uniprot id: A0A096MP06
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9555:RAB4A
gene id: 9555:RAB4A
uniprot id: A0A096MWY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9555:CD93
gene id: 9555:CD93
uniprot id: A0A096NVS3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:PODXL2
gene id: 9555:PODXL2
uniprot id: A0A096NXM6
names: Subcellular Location Annotation
messages: Membrane

9555:LRP3
gene id: 9555:LRP3
uniprot id: A0A0A0MWP7
uniprot id: A0A2I3LK30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:SSC5D
gene id: 9555:SSC5D
uniprot id: A0A2I3LS56
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ADM
gene id: 9555:ADM
uniprot id: A0A2I3LEU7
uniprot id: A0A8I5NHV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9555:VASP
gene id: 9555:VASP
uniprot id: A0A0A0MWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9555:SIDT1
gene id: 9555:SIDT1
uniprot id: A0A096N0F8
uniprot id: A0A2I3ND08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9555:NQO2
gene id: 9555:NQO2
uniprot id: A0A2I3LPX5
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9555:PIAS1
gene id: 9555:PIAS1
uniprot id: A0A096NMG3
names: Similarity
messages: Belongs to the PIAS family.

9555:ELK1
gene id: 9555:ELK1
uniprot id: A0A096ND19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:LOC101023761
gene id: 9555:LOC101023761
uniprot id: A0A096NJZ1
uniprot id: A0A2I3M1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9555:ATG9A
gene id: 9555:ATG9A
uniprot id: A0A096NPP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9555:NADK2
gene id: 9555:NADK2
uniprot id: A0A096NP16
uniprot id: A0A2I3MX30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9555:LDHC
gene id: 9555:LDHC
uniprot id: A0A096N757
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9555:LOC101007107
gene id: 9555:LOC101007107
uniprot id: A0A096N379
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9555:CXXC1
gene id: 9555:CXXC1
uniprot id: A0A096MLX7
uniprot id: A0A2I3M6U4
names: Subcellular Location Annotation
messages: Nucleus

9555:RBM42
gene id: 9555:RBM42
uniprot id: A0A2I3M3G3
names: Similarity
messages: Belongs to the RRM RBM42 family.

9555:CAMK2B
gene id: 9555:CAMK2B
uniprot id: A0A096MY92
uniprot id: A0A096NY28
uniprot id: A0A2I3LUV8
uniprot id: A0A2I3MQQ4
uniprot id: A0A2I3NEF7
uniprot id: A0A2I3NG95
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9555:DNASE2
gene id: 9555:DNASE2
uniprot id: A0A8I5NXG3
names: Similarity
messages: Belongs to the DNase II family.

9555:CSGALNACT1
gene id: 9555:CSGALNACT1
uniprot id: A0A096NXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9555:PTAR1
gene id: 9555:PTAR1
uniprot id: A0A096P1Q3
uniprot id: A0A8I5N175
uniprot id: A0A8I5NQH1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9555:A4GNT
gene id: 9555:A4GNT
uniprot id: A0A8I5NLB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9555:BECN1
gene id: 9555:BECN1
uniprot id: A0A096P5V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9555:NMB
gene id: 9555:NMB
uniprot id: A0A2I3M8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9555:TMEM80
gene id: 9555:TMEM80
uniprot id: A0A096MRI5
names: Subcellular Location Annotation
messages: Membrane

9555:SPSB4
gene id: 9555:SPSB4
uniprot id: A0A096MWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9555:DNAJC27
gene id: 9555:DNAJC27
uniprot id: A0A2I3M950
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9555:HSD17B2
gene id: 9555:HSD17B2
uniprot id: A0A096NPH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9555:CERT1
gene id: 9555:CERT1
uniprot id: A0A096N9I9
uniprot id: A0A2I3LCQ5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9555:LOC101022162
gene id: 9555:LOC101022162
uniprot id: A0A096MZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9555:NKX3-1
gene id: 9555:NKX3-1
uniprot id: A0A2I3MAN9
names: Subcellular Location Annotation
messages: Nucleus

9555:NSUN2
gene id: 9555:NSUN2
uniprot id: A0A2I3LHT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9555:TPH2
gene id: 9555:TPH2
uniprot id: A0A096N129
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9555:IDI1
gene id: 9555:IDI1
uniprot id: A0A096P372
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9555:MAT1A
gene id: 9555:MAT1A
uniprot id: A0A096P4G0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9555:LMOD3
gene id: 9555:LMOD3
uniprot id: A0A096MWL8
names: Subcellular Location Annotation
messages: cytoskeleton

9555:EN1
gene id: 9555:EN1
uniprot id: A0A2I3LZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9555:ELOVL3
gene id: 9555:ELOVL3
uniprot id: A0A096P6D7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9555:LOC101009144
gene id: 9555:LOC101009144
uniprot id: A0A8I5R280
names: Similarity
messages: Belongs to the MS4A family.

9555:CDH6
gene id: 9555:CDH6
uniprot id: A0A096MV12
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9555:BCL9L
gene id: 9555:BCL9L
uniprot id: A0A096MZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9555:SLC9B1
gene id: 9555:SLC9B1
uniprot id: A0A096MS92
names: Subcellular Location Annotation
messages: Membrane

9555:E2F8
gene id: 9555:E2F8
uniprot id: A0A096MSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:PPP5C
gene id: 9555:PPP5C
uniprot id: A0A0A0MV89
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9555:PIP4P2
gene id: 9555:PIP4P2
uniprot id: A0A096NBF4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9555:GMDS
gene id: 9555:GMDS
uniprot id: A0A8I5N4M8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9555:CHST13
gene id: 9555:CHST13
uniprot id: A0A096NXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9555:DNAJC10
gene id: 9555:DNAJC10
uniprot id: A0A096MYK3
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9555:FAM241A
gene id: 9555:FAM241A
uniprot id: A0A096N8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9555:LOC101003239
gene id: 9555:LOC101003239
uniprot id: A0A096NE90
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9555:ASB7
gene id: 9555:ASB7
uniprot id: A0A096NNE9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9555:RUNX2
gene id: 9555:RUNX2
uniprot id: A0A096NIQ2
uniprot id: A0A096NIQ3
names: Subcellular Location Annotation
messages: Nucleus

9555:THTPA
gene id: 9555:THTPA
uniprot id: A0A2I3NDE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9555:ADPRM
gene id: 9555:ADPRM
uniprot id: A0A096P2Y0
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9555:SLC35A3
gene id: 9555:SLC35A3
uniprot id: A0A096NGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9555:MAL
gene id: 9555:MAL
uniprot id: A0A8I5NLH4
names: Subcellular Location Annotation
messages: Membrane

9555:TRAPPC9
gene id: 9555:TRAPPC9
uniprot id: A0A096MY20
names: Similarity
messages: Belongs to the NIBP family.

9555:LOC116268553
gene id: 9555:LOC116268553
uniprot id: A0A8I5MZN8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9555:CD3E
gene id: 9555:CD3E
uniprot id: A0A2I3NE27
names: Subcellular Location Annotation
messages: Membrane

9555:SGO1
gene id: 9555:SGO1
uniprot id: A0A096N8Y8
uniprot id: A0A2I3NFR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9555:HNRNPA2B1
gene id: 9555:HNRNPA2B1
uniprot id: A0A2I3M8I3
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9555:TCP10L
gene id: 9555:TCP10L
uniprot id: A9CAY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9555:SPRR1B
gene id: 9555:SPRR1B
uniprot id: A0A8I5N9P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9555:HIP1R
gene id: 9555:HIP1R
uniprot id: A0A096NBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

9555:UBE2L6
gene id: 9555:UBE2L6
uniprot id: A0A096MUV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9555:SHANK1
gene id: 9555:SHANK1
uniprot id: A0A8I5P440
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

9555:DEFB132
gene id: 9555:DEFB132
uniprot id: A0A096NV24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:MED9
gene id: 9555:MED9
uniprot id: A0A096P318
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9555:ASTL
gene id: 9555:ASTL
uniprot id: A0A096NWF9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:BARX1
gene id: 9555:BARX1
uniprot id: A0A096P252
names: Subcellular Location Annotation
messages: Nucleus

9555:PTK6
gene id: 9555:PTK6
uniprot id: A0A096NN61
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9555:SETD7
gene id: 9555:SETD7
uniprot id: A0A096MZ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9555:PRORP
gene id: 9555:PRORP
uniprot id: A0A096NUL2
uniprot id: A0A2I3N6V4
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9555:LOC101002868
gene id: 9555:LOC101002868
uniprot id: A0A096NZ91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9555:AK1
gene id: 9555:AK1
uniprot id: A0A096P1Z5
uniprot id: A0A2I3MCP8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9555:FGF6
gene id: 9555:FGF6
uniprot id: A0A096NPK6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9555:SEC61B
gene id: 9555:SEC61B
uniprot id: A0A2I3N4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9555:RAD17
gene id: 9555:RAD17
uniprot id: A0A096NB75
uniprot id: A0A2I3NG14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9555:CELF6
gene id: 9555:CELF6
uniprot id: A0A096NMM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9555:LOC101017878
gene id: 9555:LOC101017878
uniprot id: A0A096MWW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9555:CTBP1
gene id: 9555:CTBP1
uniprot id: A0A096N3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9555:ART4
gene id: 9555:ART4
uniprot id: A0A096MVI2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9555:PLP1
gene id: 9555:PLP1
uniprot id: A0A096NXY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9555:MEPCE
gene id: 9555:MEPCE
uniprot id: A0A096NGW6
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9555:ADORA1
gene id: 9555:ADORA1
uniprot id: A0A096NBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9555:MMUT
gene id: 9555:MMUT
uniprot id: A0A096NIZ4
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9555:TBCA
gene id: 9555:TBCA
uniprot id: A0A2I3NAV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9555:MAPK10
gene id: 9555:MAPK10
uniprot id: A0A096NBS6
uniprot id: A0A2I3MKV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9555:GGT6
gene id: 9555:GGT6
uniprot id: A0A096P2F9
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9555:SSR3
gene id: 9555:SSR3
uniprot id: A0A096NA71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9555:NUDT1
gene id: 9555:NUDT1
uniprot id: A0A2I3LD54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9555:SKP1
gene id: 9555:SKP1
uniprot id: A0A096MSB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9555:FAM13A
gene id: 9555:FAM13A
uniprot id: A0A096N0Q0
uniprot id: A0A2I3LQ11
names: Similarity
messages: Belongs to the FAM13 family.

9555:HK2
gene id: 9555:HK2
uniprot id: A0A096MS63
names: Similarity
messages: Belongs to the hexokinase family.

9555:NPL
gene id: 9555:NPL
uniprot id: A0A096NG31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9555:NAGLU
gene id: 9555:NAGLU
uniprot id: A0A096P5T3
names: Subcellular Location Annotation
messages: Lysosome

9555:MSN
gene id: 9555:MSN
uniprot id: A0A096MSB9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9555:EDEM2
gene id: 9555:EDEM2
uniprot id: A0A096NUQ6
uniprot id: A0A2I3MIJ9
uniprot id: A0A8I5NDP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9555:LPAR5
gene id: 9555:LPAR5
uniprot id: A0A096MLI6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9555:AVPR2
gene id: 9555:AVPR2
uniprot id: A9CB48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

9555:DHFR2
gene id: 9555:DHFR2
uniprot id: A0A096P300
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9555:BRS3
gene id: 9555:BRS3
uniprot id: A0A096N1F9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9555:MYRF
gene id: 9555:MYRF
uniprot id: A0A2I3NA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9555:IRGQ
gene id: 9555:IRGQ
uniprot id: A0A0A0MUL6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9555:EIF3D
gene id: 9555:EIF3D
uniprot id: A0A2I3MYN4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9555:POU2F2
gene id: 9555:POU2F2
uniprot id: A0A0A0MVF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9555:RRM2B
gene id: 9555:RRM2B
uniprot id: A0A096N728
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9555:HTR3B
gene id: 9555:HTR3B
uniprot id: A0A096NGY7
names: Subcellular Location Annotation
messages: Membrane

9555:SELENOI
gene id: 9555:SELENOI
uniprot id: A0A8I5NU95
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9555:FABP4
gene id: 9555:FABP4
uniprot id: A0A8I5NGC9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9555:MAPK8
gene id: 9555:MAPK8
uniprot id: A0A2I3MLZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9555:TBX18
gene id: 9555:TBX18
uniprot id: A0A096NF47
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:USB1
gene id: 9555:USB1
uniprot id: A0A2I3MDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9555:SUPT20H
gene id: 9555:SUPT20H
uniprot id: A0A096N1C9
uniprot id: A0A2I3LIM1
names: Similarity
messages: Belongs to the SPT20 family.

9555:PPP4R3A
gene id: 9555:PPP4R3A
uniprot id: A0A096NRI3
names: Similarity
messages: Belongs to the SMEK family.

9555:SOX14
gene id: 9555:SOX14
uniprot id: A0A096MSU2
names: Subcellular Location Annotation
messages: Nucleus

9555:LOC101005217
gene id: 9555:LOC101005217
uniprot id: A0A8I5R6I5
names: Similarity
messages: Belongs to the PRR23 family.

9555:ZSCAN20
gene id: 9555:ZSCAN20
uniprot id: A0A096MUB0
uniprot id: A0A2I3MIP6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9555:OLR154
gene id: 9555:OLR154
uniprot id: A9L8Z7
names: Subcellular Location Annotation
messages: Membrane

9555:C13H9orf78
gene id: 9555:C13H9orf78
uniprot id: A0A096P0G8
names: Similarity
messages: Belongs to the TLS1 family.

9555:DCC
gene id: 9555:DCC
uniprot id: A0A2I3LPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9555:VAMP8
gene id: 9555:VAMP8
uniprot id: A0A2I3MIA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9555:CMTM7
gene id: 9555:CMTM7
uniprot id: A0A2I3LKX6
uniprot id: A0A8I5N039
names: Subcellular Location Annotation
messages: Membrane

9555:CITED1
gene id: 9555:CITED1
uniprot id: A0A8I5R0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9555:VPS18
gene id: 9555:VPS18
uniprot id: A0A096NTJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9555:GABRB2
gene id: 9555:GABRB2
uniprot id: A0A096MNJ0
uniprot id: A0A2I3N1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9555:STAR
gene id: 9555:STAR
uniprot id: A0A096N0P1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9555:IRF3
gene id: 9555:IRF3
uniprot id: A0A2I3LIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9555:FAM210A
gene id: 9555:FAM210A
uniprot id: A0A096N8Z4
names: Similarity
messages: Belongs to the FAM210 family.

9555:BCLAF3
gene id: 9555:BCLAF3
uniprot id: A0A096MXY3
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9555:UCKL1
gene id: 9555:UCKL1
uniprot id: A0A096NN41
uniprot id: A0A2I3MRB8
names: Similarity
messages: Belongs to the uridine kinase family.

9555:DNAJA1
gene id: 9555:DNAJA1
uniprot id: A0A2I3LLW0
names: Subcellular Location Annotation
messages: Membrane

9555:SNX11
gene id: 9555:SNX11
uniprot id: A0A096P418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9555:LOC101004221
gene id: 9555:LOC101004221
uniprot id: A0A096MUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9555:MRPL23
gene id: 9555:MRPL23
uniprot id: A0A096MM71
uniprot id: A9L954
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9555:ST8SIA5
gene id: 9555:ST8SIA5
uniprot id: A0A096MYU8
uniprot id: A0A2I3MQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:MS4A13
gene id: 9555:MS4A13
uniprot id: A0A096MW79
names: Similarity
messages: Belongs to the MS4A family.

9555:CDC20
gene id: 9555:CDC20
uniprot id: A0A096MX65
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9555:ATP5MG
gene id: 9555:ATP5MG
uniprot id: A0A096MRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9555:ACTR3
gene id: 9555:ACTR3
uniprot id: A0A096NFB8
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9555:SRPX
gene id: 9555:SRPX
uniprot id: A0A096MN41
uniprot id: A0A2I3MLD7
uniprot id: A0A2I3MSZ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:LOC101026125
gene id: 9555:LOC101026125
uniprot id: A0A096N7Q3
uniprot id: A0A2I3M5V6
names: Similarity
messages: Belongs to the intermediate filament family.

9555:ZHX1
gene id: 9555:ZHX1
uniprot id: A0A096N8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9555:EPC2
gene id: 9555:EPC2
uniprot id: A0A096NSM8
uniprot id: A0A2I3N8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9555:ITPRIPL1
gene id: 9555:ITPRIPL1
uniprot id: A0A096NPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9555:LOC101011139
gene id: 9555:LOC101011139
uniprot id: A0A096MX89
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9555:UBA52
gene id: 9555:UBA52
uniprot id: A0A2I3MBB6
uniprot id: A0A8I5R2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9555:STX16
gene id: 9555:STX16
uniprot id: A0A2I3LYT2
uniprot id: A0A2I3MMD1
names: Similarity
messages: Belongs to the syntaxin family.

9555:KRT15
gene id: 9555:KRT15
uniprot id: A0A096P5M9
names: Similarity
messages: Belongs to the intermediate filament family.

9555:ROGDI
gene id: 9555:ROGDI
uniprot id: A0A096NLH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Perikaryon
messages: Presynapse
messages: synaptic vesicle

9555:SFMBT1
gene id: 9555:SFMBT1
uniprot id: A0A096N7P6
names: Subcellular Location Annotation
messages: Nucleus

9555:TFAP2B
gene id: 9555:TFAP2B
uniprot id: A0A2I3LQ56
names: Similarity
messages: Belongs to the AP-2 family.

9555:DESI2
gene id: 9555:DESI2
uniprot id: A0A2I3LL11
names: Similarity
messages: Belongs to the DeSI family.

9555:PACSIN1
gene id: 9555:PACSIN1
uniprot id: A0A096NHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9555:GDE1
gene id: 9555:GDE1
uniprot id: A0A096NUJ5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9555:NKX2-4
gene id: 9555:NKX2-4
uniprot id: A0A096NVR6
names: Subcellular Location Annotation
messages: Nucleus

9555:CNOT6
gene id: 9555:CNOT6
uniprot id: A0A096MLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9555:KRT14
gene id: 9555:KRT14
uniprot id: A0A096P5N3
names: Similarity
messages: Belongs to the intermediate filament family.

9555:DDX18
gene id: 9555:DDX18
uniprot id: A9RA86
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9555:ATP6V1C1
gene id: 9555:ATP6V1C1
uniprot id: A0A096N107
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9555:SYN2
gene id: 9555:SYN2
uniprot id: A0A096MUZ6
names: Similarity
messages: Belongs to the synapsin family.

9555:PLBD2
gene id: 9555:PLBD2
uniprot id: A0A8I5NRS6
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9555:NTRK3
gene id: 9555:NTRK3
uniprot id: A0A2I3M291
uniprot id: A0A2I3MUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9555:GMPR
gene id: 9555:GMPR
uniprot id: A0A2I3MCL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9555:TSHZ1
gene id: 9555:TSHZ1
uniprot id: A0A096MMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9555:HACD4
gene id: 9555:HACD4
uniprot id: A0A096P1G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:PPARD
gene id: 9555:PPARD
uniprot id: A0A096NHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9555:RANGRF
gene id: 9555:RANGRF
uniprot id: A0A096P2U5
uniprot id: A0A2I3NBM5
names: Similarity
messages: Belongs to the MOG1 family.

9555:INS
gene id: 9555:INS
uniprot id: A0A096MTW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9555:MDM1
gene id: 9555:MDM1
uniprot id: A0A096MWR7
uniprot id: A0A096MYW9
uniprot id: A0A2I3MXQ5
uniprot id: A0A8I5NFD3
uniprot id: A0A8I5P433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9555:DPH3
gene id: 9555:DPH3
uniprot id: A0A096N1S9
uniprot id: A0A8I5MYZ2
names: Similarity
messages: Belongs to the DPH3 family.

9555:RGR
gene id: 9555:RGR
uniprot id: A0A096P4E1
names: Subcellular Location Annotation
messages: Membrane

9555:ZSCAN21
gene id: 9555:ZSCAN21
uniprot id: A0A096MNR4
names: Subcellular Location Annotation
messages: Nucleus

9555:ST6GALNAC6
gene id: 9555:ST6GALNAC6
uniprot id: A0A096P1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9555:AFF2
gene id: 9555:AFF2
uniprot id: A0A2I3M3V0
uniprot id: A0A2I3MYX9
names: Similarity
messages: Belongs to the AF4 family.

9555:S100PBP
gene id: 9555:S100PBP
uniprot id: A0A096NFT5
names: Subcellular Location Annotation
messages: Nucleus

9555:ALDH8A1
gene id: 9555:ALDH8A1
uniprot id: A0A096MXD8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:MTMR4
gene id: 9555:MTMR4
uniprot id: A0A096P4U5
uniprot id: A0A8I5NJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9555:RSAD1
gene id: 9555:RSAD1
uniprot id: A0A096P4J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

9555:DCP2
gene id: 9555:DCP2
uniprot id: A0A2I3MIX2
uniprot id: A0A2I3MXV0
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9555:HK3
gene id: 9555:HK3
uniprot id: A0A096ND12
names: Similarity
messages: Belongs to the hexokinase family.

9555:SH2D1A
gene id: 9555:SH2D1A
uniprot id: A0A096NCY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9555:LOC103887933
gene id: 9555:LOC103887933
uniprot id: A0A096NNJ8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9555:HSPA4
gene id: 9555:HSPA4
uniprot id: A0A2I3MR44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9555:SERBP1
gene id: 9555:SERBP1
uniprot id: A0A8I5MVB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9555:MDH2
gene id: 9555:MDH2
uniprot id: A0A096NA99
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9555:IL9
gene id: 9555:IL9
uniprot id: A0A096N5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9555:AP3B2
gene id: 9555:AP3B2
uniprot id: A0A096NN12
uniprot id: A0A2I3LMT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9555:VPS51
gene id: 9555:VPS51
uniprot id: A0A096N0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9555:HS3ST2
gene id: 9555:HS3ST2
uniprot id: A0A8I5QZE5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9555:TSPAN5
gene id: 9555:TSPAN5
uniprot id: A0A096MWH6
uniprot id: A0A8I5MZU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:SLC18B1
gene id: 9555:SLC18B1
uniprot id: A0A096MY91
names: Subcellular Location Annotation
messages: Membrane

9555:MEF2D
gene id: 9555:MEF2D
uniprot id: A0A096MQL4
uniprot id: A0A2I3LML9
uniprot id: A0A2I3N0N0
names: Subcellular Location Annotation
messages: Nucleus

9555:REEP4
gene id: 9555:REEP4
uniprot id: A0A2I3MTB3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:SLC2A13
gene id: 9555:SLC2A13
uniprot id: A0A096MUX3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9555:KCNJ4
gene id: 9555:KCNJ4
uniprot id: A0A096NK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9555:INPP4A
gene id: 9555:INPP4A
uniprot id: A0A096NF86
uniprot id: A0A2I3N529
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9555:YWHAQ
gene id: 9555:YWHAQ
uniprot id: A0A096NIX1
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9555:LOC103876537
gene id: 9555:LOC103876537
uniprot id: A0A096NHF4
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9555:COPG1
gene id: 9555:COPG1
uniprot id: A0A096NC40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9555:ATP5F1E
gene id: 9555:ATP5F1E
uniprot id: A0A8I5N159
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9555:LOC101021752
gene id: 9555:LOC101021752
uniprot id: A0A8I5NDM8
names: Similarity
messages: Belongs to the GAGE family.

9555:PGGT1B
gene id: 9555:PGGT1B
uniprot id: A0A096MMJ7
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9555:SEZ6L2
gene id: 9555:SEZ6L2
uniprot id: A0A096NMJ8
uniprot id: A0A2I3LRH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:CD27
gene id: 9555:CD27
uniprot id: A0A096NPM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:GDI1
gene id: 9555:GDI1
uniprot id: A9CB64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9555:LOC101001071
gene id: 9555:LOC101001071
uniprot id: A0A096MR93
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9555:TGFBR1
gene id: 9555:TGFBR1
uniprot id: A0A2I3LUA8
uniprot id: A0A2I3NGA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9555:VEZT
gene id: 9555:VEZT
uniprot id: A0A096MX63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9555:ADCY1
gene id: 9555:ADCY1
uniprot id: A0A096N1U3
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9555:INKA1
gene id: 9555:INKA1
uniprot id: A0A096NQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9555:TOMM40L
gene id: 9555:TOMM40L
uniprot id: A0A096NBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9555:SF3B3
gene id: 9555:SF3B3
uniprot id: A0A096NR05
names: Subcellular Location Annotation
messages: Nucleus

9555:PTPRD
gene id: 9555:PTPRD
uniprot id: A0A2I3M5Y7
uniprot id: A0A2I3M9M4
uniprot id: A0A2I3MEL0
uniprot id: A0A2I3MPZ8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9555:FDFT1
gene id: 9555:FDFT1
uniprot id: A0A2I3LU09
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9555:TPM2
gene id: 9555:TPM2
uniprot id: A0A096P175
uniprot id: A0A2I3M895
uniprot id: A0A2I3N8T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9555:ESCO1
gene id: 9555:ESCO1
uniprot id: A0A096MVE1
names: Subcellular Location Annotation
messages: Nucleus

9555:HMGCS2
gene id: 9555:HMGCS2
uniprot id: A0A096N5K0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9555:NELL1
gene id: 9555:NELL1
uniprot id: A0A096N2K0
uniprot id: A0A2I3M554
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:MST1
gene id: 9555:MST1
uniprot id: A0A096NQZ2
uniprot id: A0A2I3MER4
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:FAM114A1
gene id: 9555:FAM114A1
uniprot id: A0A096NXP6
names: Similarity
messages: Belongs to the FAM114 family.

9555:STK17A
gene id: 9555:STK17A
uniprot id: A0A096NP08
names: Similarity
messages: Belongs to the protein kinase superfamily.

9555:RGS2
gene id: 9555:RGS2
uniprot id: A0A2I3N5Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9555:RTF2
gene id: 9555:RTF2
uniprot id: A0A096NNJ7
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9555:TTC38
gene id: 9555:TTC38
uniprot id: A0A096NKS2
names: Similarity
messages: Belongs to the TTC38 family.

9555:SLC23A3
gene id: 9555:SLC23A3
uniprot id: A0A096MN68
uniprot id: A0A2I3N9S5
names: Subcellular Location Annotation
messages: Membrane

9555:NPM1
gene id: 9555:NPM1
uniprot id: A0A2I3MVB3
names: Similarity
messages: Belongs to the nucleoplasmin family.

9555:ATP4B
gene id: 9555:ATP4B
uniprot id: A0A096NA65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9555:ANAPC13
gene id: 9555:ANAPC13
uniprot id: A0A8I5NBJ0
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9555:RPL3L
gene id: 9555:RPL3L
uniprot id: A0A096NKY6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9555:E2F6
gene id: 9555:E2F6
uniprot id: A0A8I5N9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9555:ISCA1
gene id: 9555:ISCA1
uniprot id: A0A8I5MUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9555:FAM214B
gene id: 9555:FAM214B
uniprot id: A0A096P189
names: Similarity
messages: Belongs to the FAM214 family.

9555:PGAM2
gene id: 9555:PGAM2
uniprot id: A0A096N3M5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9555:UIMC1
gene id: 9555:UIMC1
uniprot id: A0A2I3LMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9555:SLC17A6
gene id: 9555:SLC17A6
uniprot id: A0A096MX10
names: Subcellular Location Annotation
messages: Membrane

9555:PDGFRA
gene id: 9555:PDGFRA
uniprot id: A0A2I3MN46
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9555:ABCC9
gene id: 9555:ABCC9
uniprot id: A0A2I3LNL6
uniprot id: A0A2I3LP50
uniprot id: A0A2I3N477
names: Subunit
messages: Interacts with KCNJ11.

9555:LOC101005875
gene id: 9555:LOC101005875
uniprot id: A0A096NL51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Homodimer.

9555:DBNDD1
gene id: 9555:DBNDD1
uniprot id: A0A096NR46
names: Similarity
messages: Belongs to the dysbindin family.

9555:HOXA1
gene id: 9555:HOXA1
uniprot id: A9L936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9555:PJVK
gene id: 9555:PJVK
uniprot id: A0A096N3U3
names: Similarity
messages: Belongs to the gasdermin family.

9555:CDR2
gene id: 9555:CDR2
uniprot id: A0A096NHC7
names: Similarity
messages: Belongs to the CDR2 family.

9555:TBX19
gene id: 9555:TBX19
uniprot id: A0A096N9R7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9555:S100A11
gene id: 9555:S100A11
uniprot id: A0A8I5NS44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9555:TBK1
gene id: 9555:TBK1
uniprot id: A0A096MZ73
uniprot id: A0A8I5MWP2
names: Subcellular Location Annotation
messages: Cytoplasm

9555:AMT
gene id: 9555:AMT
uniprot id: A0A096MSU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9555:PFKL
gene id: 9555:PFKL
uniprot id: A0A096NIG0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:TOB1
gene id: 9555:TOB1
uniprot id: A0A096P4L7
names: Similarity
messages: Belongs to the BTG family.

9555:PSMG1
gene id: 9555:PSMG1
uniprot id: B0CM32
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity).

9555:KCTD17
gene id: 9555:KCTD17
uniprot id: A0A096NJU9
uniprot id: A0A2I3LNB4
uniprot id: A0A2I3M0A5
names: Subcellular Location Annotation
messages: Cell membrane

9555:LOC101010538
gene id: 9555:LOC101010538
uniprot id: A0A096MPA8
uniprot id: A0A2I3M1I0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9555:SLC30A7
gene id: 9555:SLC30A7
uniprot id: A0A096MYX2
uniprot id: A0A8I5NYV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9555:OGFRL1
gene id: 9555:OGFRL1
uniprot id: A0A096NQE5
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9555:LOC101000710
gene id: 9555:LOC101000710
uniprot id: A0A096NQY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9555:LOC100997059
gene id: 9555:LOC100997059
uniprot id: A0A096NZ88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9555:FZD9
gene id: 9555:FZD9
uniprot id: A0A096NAS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9555:LOC101005674
gene id: 9555:LOC101005674
uniprot id: A0A096MM34
names: Similarity
messages: Belongs to the peptidase C14A family.

9555:AICDA
gene id: 9555:AICDA
uniprot id: A0A2I3MXX2
names: Subcellular Location Annotation
messages: Cytoplasm

9555:DCLK1
gene id: 9555:DCLK1
uniprot id: A0A096MPC6
uniprot id: A0A2I3MBU0
uniprot id: A0A2I3MD97
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9555:ERCC2
gene id: 9555:ERCC2
uniprot id: A0A2I3N4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9555:LOC101001617
gene id: 9555:LOC101001617
uniprot id: A0A096NHK3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9555:FAM13C
gene id: 9555:FAM13C
uniprot id: A0A8I5N5K7
names: Similarity
messages: Belongs to the FAM13 family.

9555:SND1
gene id: 9555:SND1
uniprot id: A0A2I3N9Q6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9555:BST1
gene id: 9555:BST1
uniprot id: A0A096NZG7
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9555:RSPO2
gene id: 9555:RSPO2
uniprot id: A0A096NFK4
uniprot id: A0A8I5MZZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9555:CCDC149
gene id: 9555:CCDC149
uniprot id: A0A096NZJ9
uniprot id: A0A2I3MGB1
names: Similarity
messages: Belongs to the CCDC149 family.

9555:SLC30A9
gene id: 9555:SLC30A9
uniprot id: A0A096N794
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

9555:CLDN24
gene id: 9555:CLDN24
uniprot id: A0A096MLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9555:SLC37A4
gene id: 9555:SLC37A4
uniprot id: A0A096NCP1
uniprot id: A0A2I3MDT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9555:TNS2
gene id: 9555:TNS2
uniprot id: A0A096N5N6
uniprot id: A0A096NAD9
uniprot id: A0A2I3M7P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9555:PDLIM3
gene id: 9555:PDLIM3
uniprot id: A0A096NBY9
uniprot id: A0A2I3ML38
uniprot id: A0A2I3MTF0
names: Subcellular Location Annotation
messages: Z line

9555:SMARCA5
gene id: 9555:SMARCA5
uniprot id: A0A2I3LRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9555:HCN1
gene id: 9555:HCN1
uniprot id: A0A096MWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9555:AXL
gene id: 9555:AXL
uniprot id: A0A0A0MVB9
uniprot id: A0A2I3M777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9555:CCT6B
gene id: 9555:CCT6B
uniprot id: A0A2I3MAC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9555:SLC35E4
gene id: 9555:SLC35E4
uniprot id: A0A096NJK0
names: Subcellular Location Annotation
messages: Membrane

9555:CXCL10
gene id: 9555:CXCL10
uniprot id: A0A8I5NFY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9555:DLK2
gene id: 9555:DLK2
uniprot id: A0A096NIF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9555:ALG5
gene id: 9555:ALG5
uniprot id: A0A096NFD5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9555:AP2M1
gene id: 9555:AP2M1
uniprot id: A0A096N106
uniprot id: A0A2I3MT63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9555:TRIP12
gene id: 9555:TRIP12
uniprot id: A0A2I3LZX3
uniprot id: A0A2I3N142
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9555:CLIC5
gene id: 9555:CLIC5
uniprot id: A0A096NIR1
uniprot id: A0A8I5R2D7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9555:CBL
gene id: 9555:CBL
uniprot id: A0A096MW73
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9555:SDF4
gene id: 9555:SDF4
uniprot id: A0A096NXP2
uniprot id: A0A2I3MTS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9555:DEDD2
gene id: 9555:DEDD2
uniprot id: A0A2I3MP38
names: Subcellular Location Annotation
messages: nucleolus

9555:RGMB
gene id: 9555:RGMB
uniprot id: A0A2I3M9J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9555:DDIT4L
gene id: 9555:DDIT4L
uniprot id: A0A096MRX3
names: Similarity
messages: Belongs to the DDIT4 family.

9555:SHQ1
gene id: 9555:SHQ1
uniprot id: A0A096NPD3
names: Similarity
messages: Belongs to the SHQ1 family.

9555:RTBDN
gene id: 9555:RTBDN
uniprot id: A0A0A0MVH3
uniprot id: A0A8I5NLL9
names: Similarity
messages: Belongs to the folate receptor family.

9555:C20H19orf54
gene id: 9555:C20H19orf54
uniprot id: A0A0A0MWG0
names: Similarity
messages: Belongs to the UPF0692 family.

9555:LOC108585304
gene id: 9555:LOC108585304
uniprot id: A0A096NJ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9555:CMTM1
gene id: 9555:CMTM1
uniprot id: A0A8I5RA15
names: Subcellular Location Annotation
messages: Membrane

9555:MIS18A
gene id: 9555:MIS18A
uniprot id: A0A096NY41
uniprot id: A0A8I5NF40
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9555:FAM160B1
gene id: 9555:FAM160B1
uniprot id: A0A096NTS6
names: Similarity
messages: Belongs to the FHIP family.

9555:TMCO5A
gene id: 9555:TMCO5A
uniprot id: A0A096NTD1
uniprot id: A0A8I5R956
names: Subcellular Location Annotation
messages: Membrane

9555:ELF1
gene id: 9555:ELF1
uniprot id: A0A096MN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9555:ISOC1
gene id: 9555:ISOC1
uniprot id: A0A096MMR9
names: Similarity
messages: Belongs to the isochorismatase family.

9555:TMEM35A
gene id: 9555:TMEM35A
uniprot id: A0A8I5R6N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

9555:MTM1
gene id: 9555:MTM1
uniprot id: A0A096MWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9555:ATF7IP2
gene id: 9555:ATF7IP2
uniprot id: A0A096NLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9555:GRAP
gene id: 9555:GRAP
uniprot id: A0A096P341
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9555:MRPL15
gene id: 9555:MRPL15
uniprot id: A0A096MSE1
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9555:IFT57
gene id: 9555:IFT57
uniprot id: A0A096NDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9555:CEP57L1
gene id: 9555:CEP57L1
uniprot id: A0A2I3MCL8
names: Similarity
messages: Belongs to the translokin family.

9555:NDUFB6
gene id: 9555:NDUFB6
uniprot id: A0A096P1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9555:BEX5
gene id: 9555:BEX5
uniprot id: A0A8I5NWU6
names: Similarity
messages: Belongs to the BEX family.

9555:TAFA1
gene id: 9555:TAFA1
uniprot id: A0A096NR35
names: Similarity
messages: Belongs to the TAFA family.

9555:IL15
gene id: 9555:IL15
uniprot id: A0A096N634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9555:RHCG
gene id: 9555:RHCG
uniprot id: A0A096NN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9555:GRK6
gene id: 9555:GRK6
uniprot id: A0A2I3MBD9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9555:LOC101024405
gene id: 9555:LOC101024405
uniprot id: A0A096N7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:CRY1
gene id: 9555:CRY1
uniprot id: A0A096NGF3
uniprot id: A0A8I5NYU8
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9555:LOC101010008
gene id: 9555:LOC101010008
uniprot id: A0A096MRQ2
uniprot id: A0A096NYX5
names: Similarity
messages: Belongs to the intermediate filament family.

9555:PAQR4
gene id: 9555:PAQR4
uniprot id: A0A096NL92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9555:SOX9
gene id: 9555:SOX9
uniprot id: A0A8I5NH41
names: Subcellular Location Annotation
messages: Nucleus

9555:PPA2
gene id: 9555:PPA2
uniprot id: A0A096MN84
names: Similarity
messages: Belongs to the PPase family.

9555:SLC16A1
gene id: 9555:SLC16A1
uniprot id: A0A096MSZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9555:KCNK16
gene id: 9555:KCNK16
uniprot id: A0A096NHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9555:SSRP1
gene id: 9555:SSRP1
uniprot id: A0A096NBC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9555:LOC101015677
gene id: 9555:LOC101015677
uniprot id: A0A8I5NQ50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9555:HACD3
gene id: 9555:HACD3
uniprot id: A0A096NME0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9555:GALNT1
gene id: 9555:GALNT1
uniprot id: A0A096NYS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9555:MAPK1IP1L
gene id: 9555:MAPK1IP1L
uniprot id: A0A096NV73
names: Similarity
messages: Belongs to the MISS family.

9555:RYBP
gene id: 9555:RYBP
uniprot id: A0A8I5NQY9
names: Subcellular Location Annotation
messages: Nucleus

9555:MBOAT1
gene id: 9555:MBOAT1
uniprot id: A0A096NL80
names: Subcellular Location Annotation
messages: Membrane

9555:SH3PXD2A
gene id: 9555:SH3PXD2A
uniprot id: A0A2I3LJF2
uniprot id: A0A8I5NYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9555:HDDC2
gene id: 9555:HDDC2
uniprot id: A0A096N0Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9555:ALDH2
gene id: 9555:ALDH2
uniprot id: A0A096N8X2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9555:RPS23
gene id: 9555:RPS23
uniprot id: A0A096NP85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum