9544:RBKS
gene id: 9544:RBKS
uniprot id: F7BAI3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9544:PLA2G4A
gene id: 9544:PLA2G4A
uniprot id: A0A8J8YQ92
uniprot id: F7EEZ1
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9544:LOC702827
gene id: 9544:LOC702827
uniprot id: A0A1D5RJP8
names: Similarity
messages: Belongs to the ATG8 family.

9544:COX5A
gene id: 9544:COX5A
uniprot id: A0A8J8Y8P5
uniprot id: G7MYC6
uniprot id: Q53CF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9544:FBXO25
gene id: 9544:FBXO25
uniprot id: A0A8J8XP01
uniprot id: F6U004
uniprot id: F6U017
names: Subcellular Location Annotation
messages: Nucleus

9544:TBR1
gene id: 9544:TBR1
uniprot id: F7HMW5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:ARHGAP26
gene id: 9544:ARHGAP26
uniprot id: I0FM37
uniprot id: I0FM38
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9544:OR4F6
gene id: 9544:OR4F6
uniprot id: A0A8J8YB81
uniprot id: F7GTD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TACR1
gene id: 9544:TACR1
uniprot id: Q2WGM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9544:ITGA4
gene id: 9544:ITGA4
uniprot id: F6Z0X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:GLRA4
gene id: 9544:GLRA4
uniprot id: F7B6A7
uniprot id: F7E7S2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9544:MAD1L1
gene id: 9544:MAD1L1
uniprot id: F7HGW4
names: Similarity
messages: Belongs to the MAD1 family.

9544:SPDYE4
gene id: 9544:SPDYE4
uniprot id: F6Z698
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9544:LIN7B
gene id: 9544:LIN7B
uniprot id: H9EQG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9544:RPS8
gene id: 9544:RPS8
uniprot id: F7DV33
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9544:SPATA20
gene id: 9544:SPATA20
uniprot id: A0A5F8ADW9
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9544:CHRM1
gene id: 9544:CHRM1
uniprot id: A0A8J8YBC3
uniprot id: F7HUF6
uniprot id: P56489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
messages: Cell membrane
messages: Interacts with GPRASP2 (By similarity). Interacts with TMEM147 (By similarity).
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9544:PGPEP1
gene id: 9544:PGPEP1
uniprot id: A0A8J8Y1J7
uniprot id: F7GUB6
uniprot id: H9Z3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9544:GABRB3
gene id: 9544:GABRB3
uniprot id: F6ZKJ4
uniprot id: H9FSG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:LIPT2
gene id: 9544:LIPT2
uniprot id: F6XJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9544:HNRNPD
gene id: 9544:HNRNPD
uniprot id: A0A8J8XTP7
uniprot id: F7APH2
uniprot id: F7APJ0
uniprot id: F7AVH8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LOC100430627
gene id: 9544:LOC100430627
uniprot id: F7HIT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:SLC24A2
gene id: 9544:SLC24A2
uniprot id: H9FSI4
uniprot id: H9FSI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9544:KCTD10
gene id: 9544:KCTD10
uniprot id: H9G0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9544:MT3
gene id: 9544:MT3
uniprot id: A0A8J8XS64
uniprot id: F7C8V1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:DOK1
gene id: 9544:DOK1
uniprot id: A0A8J8XZH0
uniprot id: G7NAF3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9544:WNT4
gene id: 9544:WNT4
uniprot id: A0A5F7ZTQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:SLC39A14
gene id: 9544:SLC39A14
uniprot id: A0A1D5Q778
uniprot id: A0A1D5RIG3
uniprot id: F6U2Z9
names: Subcellular Location Annotation
messages: Membrane

9544:ESS2
gene id: 9544:ESS2
uniprot id: A0A1D5QU64
uniprot id: A0A8J8XL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9544:OR4A47
gene id: 9544:OR4A47
uniprot id: F7FJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TMBIM4
gene id: 9544:TMBIM4
uniprot id: F6TQD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:PKLR
gene id: 9544:PKLR
uniprot id: A0A5F7ZB67
names: Similarity
messages: Belongs to the pyruvate kinase family.

9544:PLD5
gene id: 9544:PLD5
uniprot id: F6ZT28
names: Similarity
messages: Belongs to the phospholipase D family.

9544:DOLPP1
gene id: 9544:DOLPP1
uniprot id: A0A8J8YPV0
uniprot id: G7NFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9544:FGF22
gene id: 9544:FGF22
uniprot id: A0A7U3JW23
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:OR4D11
gene id: 9544:OR4D11
uniprot id: A0A8J8Y5D9
uniprot id: F7C757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PRICKLE1
gene id: 9544:PRICKLE1
uniprot id: F7E2K2
uniprot id: F7HTJ1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9544:NDRG4
gene id: 9544:NDRG4
uniprot id: A0A1D5QAP4
uniprot id: A0A1D5RFU9
uniprot id: A0A5F8ALB0
uniprot id: F7GNI4
uniprot id: F7GNI6
uniprot id: H9ETE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9544:NMT1
gene id: 9544:NMT1
uniprot id: H9ESJ8
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9544:TSPYL2
gene id: 9544:TSPYL2
uniprot id: I2CU67
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:SNX30
gene id: 9544:SNX30
uniprot id: F7GDT2
names: Similarity
messages: Belongs to the sorting nexin family.

9544:SLC10A4
gene id: 9544:SLC10A4
uniprot id: F7HJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:HPDL
gene id: 9544:HPDL
uniprot id: F7GQP6
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9544:CHRM3
gene id: 9544:CHRM3
uniprot id: A0A8J8XRC4
uniprot id: F7EAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9544:SMAD3
gene id: 9544:SMAD3
uniprot id: A0A1D5Q1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:OSGEP
gene id: 9544:OSGEP
uniprot id: A0A8J8XC35
uniprot id: F7FCR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9544:BLOC1S1
gene id: 9544:BLOC1S1
uniprot id: H9Z1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9544:MFSD6
gene id: 9544:MFSD6
uniprot id: F7FBJ5
uniprot id: I2CU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9544:RNASE3
gene id: 9544:RNASE3
uniprot id: A0A5K1V6L7
uniprot id: F7GKX7
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:MRPL34
gene id: 9544:MRPL34
uniprot id: F6YJR8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9544:TMED1
gene id: 9544:TMED1
uniprot id: A0A8J8Y0R0
uniprot id: F7GWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:OLFML1
gene id: 9544:OLFML1
uniprot id: A0A1D5Q6D5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RPL37
gene id: 9544:RPL37
uniprot id: F7HR63
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9544:GNB5
gene id: 9544:GNB5
uniprot id: H9FNX2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:CER1
gene id: 9544:CER1
uniprot id: A0A8J8YHW6
uniprot id: F7DJA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MFN1
gene id: 9544:MFN1
uniprot id: F6ZJ43
uniprot id: H9ZB20
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9544:NCAM1
gene id: 9544:NCAM1
uniprot id: H9FUS4
uniprot id: H9FUS8
uniprot id: H9FUS9
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

9544:CEPT1
gene id: 9544:CEPT1
uniprot id: A0A8J8Y579
uniprot id: F7HL54
uniprot id: F7HL57
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9544:STX17
gene id: 9544:STX17
uniprot id: A0A8J8YBJ7
uniprot id: F6VSJ7
names: Similarity
messages: Belongs to the syntaxin family.

9544:EXOC8
gene id: 9544:EXOC8
uniprot id: A0A8J8Y3H5
uniprot id: F7BWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9544:TMEM87A
gene id: 9544:TMEM87A
uniprot id: A0A8J8Y0B0
uniprot id: F7GAX2
names: Subcellular Location Annotation
messages: Membrane

9544:IPMK
gene id: 9544:IPMK
uniprot id: A0A5F7ZMJ6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9544:PSME3
gene id: 9544:PSME3
uniprot id: A0A1D5QZ01
uniprot id: H9FNI9
names: Similarity
messages: Belongs to the PA28 family.

9544:NKX6-2
gene id: 9544:NKX6-2
uniprot id: F7HT95
names: Subcellular Location Annotation
messages: Nucleus

9544:JRKL
gene id: 9544:JRKL
uniprot id: A0A8J8XE79
uniprot id: F7HRC6
names: Subcellular Location Annotation
messages: Nucleus

9544:TSR2
gene id: 9544:TSR2
uniprot id: F7F4W3
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9544:HP
gene id: 9544:HP
uniprot id: H9Z8D4
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ING3
gene id: 9544:ING3
uniprot id: A0A8J8XD65
uniprot id: G7MM72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:MID2
gene id: 9544:MID2
uniprot id: A0A5F8AM63
uniprot id: H9FP73
uniprot id: I0FKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9544:PRR5
gene id: 9544:PRR5
uniprot id: F7GAR1
uniprot id: I0FT82
names: Similarity
messages: Belongs to the PROTOR family.

9544:CCNC
gene id: 9544:CCNC
uniprot id: A0A1D5Q0W7
uniprot id: H9EQS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9544:ABLIM1
gene id: 9544:ABLIM1
uniprot id: F6YH36
names: Subcellular Location Annotation
messages: Cytoplasm

9544:GJB5
gene id: 9544:GJB5
uniprot id: A0A8J8XC79
uniprot id: F7GQL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:EXOSC9
gene id: 9544:EXOSC9
uniprot id: H9FVZ0
names: Subcellular Location Annotation
messages: Cytoplasm

9544:THBS3
gene id: 9544:THBS3
uniprot id: A0A8J8Y2S0
uniprot id: F6ZVD5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NONO
gene id: 9544:NONO
uniprot id: A0A5F7ZCD6
uniprot id: A0A8J8YAT5
uniprot id: G7NRV6
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:CXCL13
gene id: 9544:CXCL13
uniprot id: A0A8J8XAP4
uniprot id: Q8HYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:DTX2
gene id: 9544:DTX2
uniprot id: A0A8J8YIG4
uniprot id: F6WRL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9544:CALCR
gene id: 9544:CALCR
uniprot id: F7D5E4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9544:RALB
gene id: 9544:RALB
uniprot id: A0A1D5R129
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9544:GPR180
gene id: 9544:GPR180
uniprot id: A0A8J8XQH1
uniprot id: F7H5N5
names: Subcellular Location Annotation
messages: Membrane

9544:HIST1H2AE
gene id: 9544:HIST1H2AE
uniprot id: G7MR18
uniprot id: G7MR36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:FSHR
gene id: 9544:FSHR
uniprot id: A0A8J8YC40
uniprot id: F7HGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

9544:PABPC3
gene id: 9544:PABPC3
uniprot id: F7HQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:RNF8
gene id: 9544:RNF8
uniprot id: F7BPD6
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9544:RDH5
gene id: 9544:RDH5
uniprot id: A0A8J8YR78
uniprot id: G7N797
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:ZNF213
gene id: 9544:ZNF213
uniprot id: G7NP67
names: Subcellular Location Annotation
messages: Nucleus

9544:IMMP2L
gene id: 9544:IMMP2L
uniprot id: F6RN87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9544:PDCL
gene id: 9544:PDCL
uniprot id: A0A8J8XHW7
uniprot id: F7F3M0
names: Similarity
messages: Belongs to the phosducin family.

9544:RBP2
gene id: 9544:RBP2
uniprot id: A0A8J8YCU1
uniprot id: F6VER9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:PRSS35
gene id: 9544:PRSS35
uniprot id: Q1WK24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 342 which is replaced by a Thr, suggesting that it has no protease activity.
messages: Belongs to the peptidase S1 family.
messages: Secreted

9544:ELK1
gene id: 9544:ELK1
uniprot id: F6R9C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:MRPL27
gene id: 9544:MRPL27
uniprot id: H9Z9Q6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9544:GALNT10
gene id: 9544:GALNT10
uniprot id: F7BKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:FAM18B1
gene id: 9544:FAM18B1
uniprot id: G7NN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9544:NIPA2
gene id: 9544:NIPA2
uniprot id: A0A5F8A8Z9
uniprot id: A0A8J8XF62
uniprot id: F7DAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9544:C5AR2
gene id: 9544:C5AR2
uniprot id: F7H5Z8
names: Subcellular Location Annotation
messages: Cell membrane

9544:LOC709878
gene id: 9544:LOC709878
uniprot id: G7NS87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SH3GL3
gene id: 9544:SH3GL3
uniprot id: A0A5F7ZHJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9544:BAMBI
gene id: 9544:BAMBI
uniprot id: H9FSJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9544:ACOT8
gene id: 9544:ACOT8
uniprot id: A0A5F7Z994
uniprot id: F7G1G6
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9544:RFLNA
gene id: 9544:RFLNA
uniprot id: A0A1D5QKS2
uniprot id: A0A8J8YB94
uniprot id: F7DM58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9544:PNN
gene id: 9544:PNN
uniprot id: G7MXN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9544:RPL17
gene id: 9544:RPL17
uniprot id: F7CL39
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9544:MRPL43
gene id: 9544:MRPL43
uniprot id: H9EVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9544:MVK
gene id: 9544:MVK
uniprot id: G7N5F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9544:PPP4R3A
gene id: 9544:PPP4R3A
uniprot id: H9EMJ9
names: Similarity
messages: Belongs to the SMEK family.

9544:TRIAP1
gene id: 9544:TRIAP1
uniprot id: G7N5Y6
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9544:NNMT
gene id: 9544:NNMT
uniprot id: A0A8J8YMH4
uniprot id: F7ERX8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9544:CACNB4
gene id: 9544:CACNB4
uniprot id: A0A1D5QD77
uniprot id: A0A1D5QRN7
uniprot id: F7B1R4
uniprot id: F7B1S0
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9544:DPP4
gene id: 9544:DPP4
uniprot id: F6VRB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9544:LOC708660
gene id: 9544:LOC708660
uniprot id: F7HMW4
names: Similarity
messages: Belongs to the amidase family.

9544:MFSD14A
gene id: 9544:MFSD14A
uniprot id: H9FYH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9544:TEKT2
gene id: 9544:TEKT2
uniprot id: F7GQI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9544:LRRFIP2
gene id: 9544:LRRFIP2
uniprot id: A0A8J8XWJ0
uniprot id: G7MJ23
uniprot id: H9EPE5
uniprot id: H9EUI0
names: Similarity
messages: Belongs to the LRRFIP family.

9544:RRM1
gene id: 9544:RRM1
uniprot id: A0A8J8YB73
uniprot id: H9FY72
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9544:CMAS
gene id: 9544:CMAS
uniprot id: F7H7Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9544:FGD6
gene id: 9544:FGD6
uniprot id: A0A5F8AD44
names: Subcellular Location Annotation
messages: cytoskeleton

9544:SGSM2
gene id: 9544:SGSM2
uniprot id: F6RIF1
uniprot id: I0FWV3
names: Similarity
messages: Belongs to the RUTBC family.

9544:RHCG
gene id: 9544:RHCG
uniprot id: Q20CR3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).
messages: Homotrimer.
messages: N-glycosylated.

9544:SELENOS
gene id: 9544:SELENOS
uniprot id: F7H792
uniprot id: Q3YAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9544:GLO1
gene id: 9544:GLO1
uniprot id: A0A8J8YFN9
uniprot id: F7GRZ9
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9544:ATG5
gene id: 9544:ATG5
uniprot id: A0A5F7ZYF8
uniprot id: A0A8J8XDF0
uniprot id: F7GH37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9544:DCK
gene id: 9544:DCK
uniprot id: A0A8J8YCT9
uniprot id: G7MT46
names: Similarity
messages: Belongs to the DCK/DGK family.

9544:PRKG1
gene id: 9544:PRKG1
uniprot id: F7G3L7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9544:LOC697977
gene id: 9544:LOC697977
uniprot id: G7MR18
uniprot id: G7MR36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:PSD3
gene id: 9544:PSD3
uniprot id: F6PKT2
names: Subcellular Location Annotation
messages: ruffle membrane

9544:TMC3
gene id: 9544:TMC3
uniprot id: F7BM03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9544:SLC25A4
gene id: 9544:SLC25A4
uniprot id: F6QA37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:RPN2
gene id: 9544:RPN2
uniprot id: F7CA11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:BTF3L4
gene id: 9544:BTF3L4
uniprot id: A0A8J8XI51
uniprot id: G7MH02
names: Similarity
messages: Belongs to the NAC-beta family.

9544:POLB
gene id: 9544:POLB
uniprot id: A0A8J8XKC3
uniprot id: I0FSR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9544:ODF1
gene id: 9544:ODF1
uniprot id: A0A8J8Y6E8
uniprot id: F6UXN0
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9544:HDAC3
gene id: 9544:HDAC3
uniprot id: A0A8J8YMG0
uniprot id: H9G1C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9544:EPCAM
gene id: 9544:EPCAM
uniprot id: Q1WER1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPCAM family.
messages: Glycosylation at Asn-198 is crucial for protein stability.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).
messages: Monomer. Interacts with phosphorylated CLDN7 (By similarity).
messages: tight junction

9544:LCA5L
gene id: 9544:LCA5L
uniprot id: F7D2V2
names: Similarity
messages: Belongs to the LCA5 family.

9544:LHX5
gene id: 9544:LHX5
uniprot id: A0A5F7ZB76
names: Subcellular Location Annotation
messages: Nucleus

9544:EIF4EBP3
gene id: 9544:EIF4EBP3
uniprot id: A0A5F8AKH1
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9544:STK4
gene id: 9544:STK4
uniprot id: A4K2T0
uniprot id: F6XFA0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3 (By similarity).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 and SCRIB in the presence of DLG5.
messages: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity).
messages: Nucleus
messages: Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog (By similarity).
messages: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

9544:DNASE1L2
gene id: 9544:DNASE1L2
uniprot id: A0A1D5QZP0
names: Similarity
messages: Belongs to the DNase I family.

9544:SDAD1
gene id: 9544:SDAD1
uniprot id: A0A1D5QV33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9544:S1PR5
gene id: 9544:S1PR5
uniprot id: A0A8J8YDP6
uniprot id: G7NL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9544:DRD3
gene id: 9544:DRD3
uniprot id: A0A8J8XQZ3
uniprot id: F6U709
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9544:AIP
gene id: 9544:AIP
uniprot id: A0A8J8YP73
uniprot id: F7H7B6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9544:HIST1H2BM
gene id: 9544:HIST1H2BM
uniprot id: A0A8J8YQ31
uniprot id: G7MR89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:RETN
gene id: 9544:RETN
uniprot id: F5CLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9544:SERPINB12
gene id: 9544:SERPINB12
uniprot id: G7NKU4
names: Similarity
messages: Belongs to the serpin family.

9544:PIK3CA
gene id: 9544:PIK3CA
uniprot id: H9FVU5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:LPCAT4
gene id: 9544:LPCAT4
uniprot id: F7H2G9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:PDGFD
gene id: 9544:PDGFD
uniprot id: I0FL09
uniprot id: I0FL10
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC100425237
gene id: 9544:LOC100425237
uniprot id: W0UUV6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:DYRK3
gene id: 9544:DYRK3
uniprot id: F7FZF8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:DPY19L4
gene id: 9544:DPY19L4
uniprot id: H9FTA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9544:SRPRA
gene id: 9544:SRPRA
uniprot id: F6ZRH2
uniprot id: F7HSU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9544:PIAS4
gene id: 9544:PIAS4
uniprot id: A0A1D5QIZ9
uniprot id: H9Z9X4
names: Similarity
messages: Belongs to the PIAS family.

9544:DDIT4
gene id: 9544:DDIT4
uniprot id: A0A8J8XRK8
uniprot id: F7DLT7
names: Similarity
messages: Belongs to the DDIT4 family.

9544:STAMBP
gene id: 9544:STAMBP
uniprot id: A0A8J8Y8Y0
uniprot id: G7NAC8
names: Similarity
messages: Belongs to the peptidase M67C family.

9544:CCNQ
gene id: 9544:CCNQ
uniprot id: H9G1S7
uniprot id: H9G1S8
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

9544:UBE2K
gene id: 9544:UBE2K
uniprot id: A0A8J8YDV8
uniprot id: F6UEX6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:GBA
gene id: 9544:GBA
uniprot id: I2CYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

9544:NFIL3
gene id: 9544:NFIL3
uniprot id: A0A8J8Y2L5
uniprot id: F7DIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9544:NDUFA12
gene id: 9544:NDUFA12
uniprot id: A0A1D5R6K9
uniprot id: A0A8J8Y4J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:DEFB4
gene id: 9544:DEFB4
uniprot id: B0LFF5
names: Subcellular Location Annotation
messages: Secreted

9544:SF1
gene id: 9544:SF1
uniprot id: H9EPF6
uniprot id: H9EPF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9544:GABRG1
gene id: 9544:GABRG1
uniprot id: A0A5K1TUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:KRR1
gene id: 9544:KRR1
uniprot id: F6YQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9544:LIAS
gene id: 9544:LIAS
uniprot id: A0A8J8XVD6
uniprot id: F6RMC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9544:VAC14
gene id: 9544:VAC14
uniprot id: A0A8J8XD54
uniprot id: F6RXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9544:ANAPC15
gene id: 9544:ANAPC15
uniprot id: A0A8J8Y1N1
uniprot id: H9FSL4
names: Similarity
messages: Belongs to the APC15 family.

9544:ERN1
gene id: 9544:ERN1
uniprot id: A0A5F8A6W0
uniprot id: F6WBI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ERLEC1
gene id: 9544:ERLEC1
uniprot id: A0A5F7ZZC3
uniprot id: A0A8J8YPJ7
uniprot id: F6ZY27
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9544:HMGCS2
gene id: 9544:HMGCS2
uniprot id: A0A1D5QMU4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9544:OSGEPL1
gene id: 9544:OSGEPL1
uniprot id: A0A8J8XYH5
uniprot id: G7N8H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9544:TNFRSF11B
gene id: 9544:TNFRSF11B
uniprot id: G7N005
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CHMP2B
gene id: 9544:CHMP2B
uniprot id: A0A8J8YMS0
uniprot id: F7GEL2
names: Similarity
messages: Belongs to the SNF7 family.

9544:LOC699679
gene id: 9544:LOC699679
uniprot id: A0A5F8AGP2
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:STAM
gene id: 9544:STAM
uniprot id: G7N1N9
uniprot id: H9ESU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9544:NDUFA7
gene id: 9544:NDUFA7
uniprot id: A0A8J8XV89
uniprot id: G7NNA1
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9544:BPIFC
gene id: 9544:BPIFC
uniprot id: A0A8J8XMC2
uniprot id: F7HFH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9544:CTSO
gene id: 9544:CTSO
uniprot id: F6RB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9544:AHCYL2
gene id: 9544:AHCYL2
uniprot id: F6TAH9
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9544:MCM6
gene id: 9544:MCM6
uniprot id: A0A8J8XNM7
uniprot id: F6VC72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:TGIF2
gene id: 9544:TGIF2
uniprot id: A0A8J8YMK5
uniprot id: F7GYI0
names: Subcellular Location Annotation
messages: Nucleus

9544:NKRF
gene id: 9544:NKRF
uniprot id: A0A5F8AK86
names: Similarity
messages: Belongs to the CARF family.

9544:SIAH2
gene id: 9544:SIAH2
uniprot id: F6TED2
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9544:FZD6
gene id: 9544:FZD6
uniprot id: A0A8J8XSA1
uniprot id: F6QFJ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CCNB2
gene id: 9544:CCNB2
uniprot id: A0A1D5RDS1
names: Similarity
messages: Belongs to the cyclin family.

9544:RHOT2
gene id: 9544:RHOT2
uniprot id: I2CTJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9544:ENO1
gene id: 9544:ENO1
uniprot id: A0A5F7ZL29
uniprot id: A0A5F8A477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:AP1M1
gene id: 9544:AP1M1
uniprot id: F7AVN6
uniprot id: I2CUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9544:DDX43
gene id: 9544:DDX43
uniprot id: A0A8J8XP20
uniprot id: F7B8M1
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:PRKCA
gene id: 9544:PRKCA
uniprot id: A0A5F8A004
uniprot id: H9EMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9544:PDCL2
gene id: 9544:PDCL2
uniprot id: F7H2W1
names: Similarity
messages: Belongs to the phosducin family.

9544:HRH3
gene id: 9544:HRH3
uniprot id: Q865E1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GRAP2
gene id: 9544:GRAP2
uniprot id: A0A8J8Y7W2
uniprot id: F7AN37
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9544:PDRG1
gene id: 9544:PDRG1
uniprot id: A0A8J8YM09
uniprot id: F6SXT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9544:KCNJ11
gene id: 9544:KCNJ11
uniprot id: A0A8J8XTN9
uniprot id: F7HFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9544:MED10
gene id: 9544:MED10
uniprot id: A0A8J8XEA1
uniprot id: F6Z795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:SCARB1
gene id: 9544:SCARB1
uniprot id: A0A5K1VMB9
uniprot id: F7G7I7
uniprot id: H9EW01
names: Similarity
messages: Belongs to the CD36 family.

9544:LOC106995433
gene id: 9544:LOC106995433
uniprot id: A0A1D5QJ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:GARS
gene id: 9544:GARS
uniprot id: H9FSS9
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9544:CNTFR
gene id: 9544:CNTFR
uniprot id: H9FPV4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9544:DEFB121
gene id: 9544:DEFB121
uniprot id: G7N560
uniprot id: Q5J600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant expression in the male reproductive tract only.
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:FAM234A
gene id: 9544:FAM234A
uniprot id: A0A8J8Y7W3
uniprot id: F6Y977
uniprot id: I0FGW2
names: Similarity
messages: Belongs to the FAM234 family.

9544:GLUL
gene id: 9544:GLUL
uniprot id: F7CAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9544:NR1I2
gene id: 9544:NR1I2
uniprot id: Q8SQ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer with RXRA (By similarity). Interacts with NCOA1 (By similarity). Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).
messages: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).
messages: Nucleus

9544:LOC700564
gene id: 9544:LOC700564
uniprot id: A0A8J8XXH2
uniprot id: F6QQN0
names: Similarity
messages: Belongs to the PRAME family.

9544:GADD45A
gene id: 9544:GADD45A
uniprot id: F7HPG4
names: Similarity
messages: Belongs to the GADD45 family.

9544:DLGAP5
gene id: 9544:DLGAP5
uniprot id: H9ZFW5
names: Similarity
messages: Belongs to the SAPAP family.

9544:CDIPT
gene id: 9544:CDIPT
uniprot id: A0A8J8YHJ3
uniprot id: G7NQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9544:RHBDD2
gene id: 9544:RHBDD2
uniprot id: A0A8J8XCQ4
uniprot id: G7MNZ0
names: Subcellular Location Annotation
messages: Membrane

9544:TUBB4A
gene id: 9544:TUBB4A
uniprot id: A0A1D5QPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:SMG9
gene id: 9544:SMG9
uniprot id: A0A5F7ZW06
uniprot id: F6Z1W2
names: Similarity
messages: Belongs to the SMG9 family.

9544:SEC61A2
gene id: 9544:SEC61A2
uniprot id: F7H2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:FN3K
gene id: 9544:FN3K
uniprot id: A0A5K1V2Q8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9544:TEF
gene id: 9544:TEF
uniprot id: H9EME2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9544:EMP2
gene id: 9544:EMP2
uniprot id: F6THT0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9544:PCSK1
gene id: 9544:PCSK1
uniprot id: H9FVB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9544:KLRD1
gene id: 9544:KLRD1
uniprot id: Q9MZK9
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation.
messages: Cell membrane
messages: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.
messages: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules.
messages: KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
messages: Natural killer cells.

9544:IL20
gene id: 9544:IL20
uniprot id: F7HHX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9544:NINJ2
gene id: 9544:NINJ2
uniprot id: A0A1D5R217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9544:PPP1R9A
gene id: 9544:PPP1R9A
uniprot id: A0A1D5QXY8
uniprot id: F7H7K4
uniprot id: F7HLC5
names: Subcellular Location Annotation
messages: cytoskeleton

9544:HNRNPK
gene id: 9544:HNRNPK
uniprot id: F6VJH6
uniprot id: F6WZ02
uniprot id: F6WZ20
uniprot id: F7H3M0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9544:CENPV
gene id: 9544:CENPV
uniprot id: H9Z660
names: Similarity
messages: Belongs to the Gfa family.

9544:APOC1
gene id: 9544:APOC1
uniprot id: H9FNA4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.
messages: Belongs to the apolipoprotein C1 family.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9544:L3HYPDH
gene id: 9544:L3HYPDH
uniprot id: A0A1D5QWA4
names: Similarity
messages: Belongs to the proline racemase family.

9544:MED31
gene id: 9544:MED31
uniprot id: A0A8J8XBQ4
uniprot id: F7GVH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9544:COPE
gene id: 9544:COPE
uniprot id: I0FNY4
uniprot id: I0FNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9544:ATG2B
gene id: 9544:ATG2B
uniprot id: F6PWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9544:DMTN
gene id: 9544:DMTN
uniprot id: H9FR35
uniprot id: I0FPW8
uniprot id: I0FPW9
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TMEM218
gene id: 9544:TMEM218
uniprot id: A0A8J8YK52
uniprot id: G7NCW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9544:ACADM
gene id: 9544:ACADM
uniprot id: F7H483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9544:NXPH4
gene id: 9544:NXPH4
uniprot id: F7DEE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:PREB
gene id: 9544:PREB
uniprot id: F6PQ58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9544:NR5A1
gene id: 9544:NR5A1
uniprot id: A0A5K1UJF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9544:SATB2
gene id: 9544:SATB2
uniprot id: H9EQF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:ZFP36L1
gene id: 9544:ZFP36L1
uniprot id: A0A8J8YSY5
uniprot id: G7MYI0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9544:BMPR1A
gene id: 9544:BMPR1A
uniprot id: F7H4T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:FAM49B
gene id: 9544:FAM49B
uniprot id: A0A8J8XFX4
uniprot id: F6YP94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9544:NTN4
gene id: 9544:NTN4
uniprot id: F7A3Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RIPK2
gene id: 9544:RIPK2
uniprot id: F6Q6C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9544:TBX5
gene id: 9544:TBX5
uniprot id: A0A8J8XSR3
uniprot id: F7FPV2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:WDR45
gene id: 9544:WDR45
uniprot id: F7BK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

9544:ATP6V0A1
gene id: 9544:ATP6V0A1
uniprot id: A0A8J8XCE0
uniprot id: F7FMM0
uniprot id: G7NIL3
uniprot id: H9ZA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9544:DIS3L
gene id: 9544:DIS3L
uniprot id: H9EV62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

9544:IRF1
gene id: 9544:IRF1
uniprot id: A0A1D5QDW4
uniprot id: A0A8J8YKS2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:PYM1
gene id: 9544:PYM1
uniprot id: F7GQZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9544:TMEM116
gene id: 9544:TMEM116
uniprot id: A0A5F8AD19
names: Subcellular Location Annotation
messages: Membrane

9544:PKM
gene id: 9544:PKM
uniprot id: F7FI45
uniprot id: I0FSN6
names: Similarity
messages: Belongs to the pyruvate kinase family.

9544:AQP3
gene id: 9544:AQP3
uniprot id: A0A8J8XVT7
uniprot id: F7EHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9544:MRPS14
gene id: 9544:MRPS14
uniprot id: A0A8J8Y9Q3
uniprot id: F7GV86
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9544:KRT18
gene id: 9544:KRT18
uniprot id: F6VBK4
names: Similarity
messages: Belongs to the intermediate filament family.

9544:PRPSAP2
gene id: 9544:PRPSAP2
uniprot id: A0A1D5Q5E7
uniprot id: G8F168
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9544:XRCC6
gene id: 9544:XRCC6
uniprot id: H9ET71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9544:PAIP2B
gene id: 9544:PAIP2B
uniprot id: A0A8J8Y192
uniprot id: G7NAB1
names: Similarity
messages: Belongs to the PAIP2 family.

9544:EPHB3
gene id: 9544:EPHB3
uniprot id: F7ELA0
names: Subcellular Location Annotation
messages: Membrane

9544:CCDC167
gene id: 9544:CCDC167
uniprot id: F6PPR1
names: Subcellular Location Annotation
messages: Membrane

9544:MYH10
gene id: 9544:MYH10
uniprot id: A0A5K1U9D0
uniprot id: H9ENN2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:LOX
gene id: 9544:LOX
uniprot id: A0A5F8A8E7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9544:PPFIA2
gene id: 9544:PPFIA2
uniprot id: F6T6Z8
uniprot id: H9G107
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9544:SHCBP1L
gene id: 9544:SHCBP1L
uniprot id: F6WVF4
names: Subcellular Location Annotation
messages: spindle

9544:SLC25A23
gene id: 9544:SLC25A23
uniprot id: A0A5F8AM04
uniprot id: F6WKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:VAMP1
gene id: 9544:VAMP1
uniprot id: H9FYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9544:GREM2
gene id: 9544:GREM2
uniprot id: A0A8J8YPE8
uniprot id: F7HBP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:KIF5B
gene id: 9544:KIF5B
uniprot id: F6UPB7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:INTS8
gene id: 9544:INTS8
uniprot id: F7GDY8
uniprot id: F7GDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9544:PROX1
gene id: 9544:PROX1
uniprot id: A0A8J8XAF2
uniprot id: G7MEK6
names: Subcellular Location Annotation
messages: Nucleus

9544:FOXA2
gene id: 9544:FOXA2
uniprot id: F7D2T8
names: Subcellular Location Annotation
messages: Nucleus

9544:ZIC1
gene id: 9544:ZIC1
uniprot id: F6SUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9544:HNRNPDL
gene id: 9544:HNRNPDL
uniprot id: F6QIA8
uniprot id: H9ESS0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:ATP5F1C
gene id: 9544:ATP5F1C
uniprot id: A0A8J8YBH1
uniprot id: G7N1K0
uniprot id: I0FJ47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9544:SLC6A4
gene id: 9544:SLC6A4
uniprot id: Q9MYX0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Monomer or homooligomer (By similarity). Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with filamentous actin and STX1A (By similarity). Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with TGFB1I1 (By similarity). Interacts with ITGAV:ITGB3 (By similarity).
messages: Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
messages: focal adhesion

9544:NPR3
gene id: 9544:NPR3
uniprot id: A0A8J8XPW1
uniprot id: G7MV21
names: Subcellular Location Annotation
messages: Membrane

9544:TGM2
gene id: 9544:TGM2
uniprot id: A0A5K1U617
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9544:LSM3
gene id: 9544:LSM3
uniprot id: A0A8J8XSW2
uniprot id: F7DGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9544:PIK3C2B
gene id: 9544:PIK3C2B
uniprot id: H9ESL7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:UBE2D4
gene id: 9544:UBE2D4
uniprot id: A0A8J8XHT2
uniprot id: F6PPG7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:CHML
gene id: 9544:CHML
uniprot id: A0A8J8XZW5
uniprot id: G7MFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9544:TAAR2
gene id: 9544:TAAR2
uniprot id: D2X5R1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SLC27A4
gene id: 9544:SLC27A4
uniprot id: A0A8J8YRX1
uniprot id: G7NFS5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:S100PBP
gene id: 9544:S100PBP
uniprot id: A0A5K1VEI4
uniprot id: F6YVA3
names: Subcellular Location Annotation
messages: Nucleus

9544:AP2S1
gene id: 9544:AP2S1
uniprot id: F6Z952
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9544:ENTPD2
gene id: 9544:ENTPD2
uniprot id: A0A5K1UXY7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:UGDH
gene id: 9544:UGDH
uniprot id: A0A1D5Q620
uniprot id: A0A8J8XHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9544:SS18L1
gene id: 9544:SS18L1
uniprot id: H9FSQ5
names: Similarity
messages: Belongs to the SS18 family.

9544:DEFB132
gene id: 9544:DEFB132
uniprot id: F7GWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:NDFIP2
gene id: 9544:NDFIP2
uniprot id: F6QC75
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9544:TRMT1
gene id: 9544:TRMT1
uniprot id: F6RHR7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9544:UCN2
gene id: 9544:UCN2
uniprot id: F7GTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9544:LANCL3
gene id: 9544:LANCL3
uniprot id: A0A1D5QWE1
names: Similarity
messages: Belongs to the LanC-like protein family.

9544:PI4K2B
gene id: 9544:PI4K2B
uniprot id: F6Q6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9544:CRHR1
gene id: 9544:CRHR1
uniprot id: Q76LL8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Endosome
messages: Expressed abundantly in the pituitary, cerebral cortex, hippocampus, amygdala and cerebellum.
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Heterodimer; heterodimerizes with GPER1. Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding (By similarity).
messages: Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
messages: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).

9544:DR1
gene id: 9544:DR1
uniprot id: A0A8J8YJE8
uniprot id: F7C9G1
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9544:FAM229B
gene id: 9544:FAM229B
uniprot id: A0A8J8Y3J6
uniprot id: F6PZM3
names: Similarity
messages: Belongs to the FAM229 family.

9544:RAB11FIP4
gene id: 9544:RAB11FIP4
uniprot id: F7HGQ6
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9544:CSE1L
gene id: 9544:CSE1L
uniprot id: A0A8J8XD27
uniprot id: G7N4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9544:HHEX
gene id: 9544:HHEX
uniprot id: F7HNF7
names: Subcellular Location Annotation
messages: Nucleus

9544:FABP1
gene id: 9544:FABP1
uniprot id: A0A8J8YFA0
uniprot id: G7NAK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9544:SFTPD
gene id: 9544:SFTPD
uniprot id: G7N227
uniprot id: Q1PBC5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPD family.
messages: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 4 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
messages: extracellular matrix
messages: surface film

9544:GLI1
gene id: 9544:GLI1
uniprot id: I0FMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9544:RBM15B
gene id: 9544:RBM15B
uniprot id: F6ZSK0
names: Similarity
messages: Belongs to the RRM Spen family.

9544:MS4A2
gene id: 9544:MS4A2
uniprot id: A0A5F8AV45
names: Similarity
messages: Belongs to the MS4A family.

9544:PRICKLE2
gene id: 9544:PRICKLE2
uniprot id: A0A8J8XED2
uniprot id: F7GCX1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9544:CYP2C8
gene id: 9544:CYP2C8
uniprot id: Q6GUQ7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:OR6M1
gene id: 9544:OR6M1
uniprot id: F6X8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:VPS13A
gene id: 9544:VPS13A
uniprot id: A0A5F7ZDA0
uniprot id: A0A5F8A7C7
uniprot id: F7AQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9544:SPSB1
gene id: 9544:SPSB1
uniprot id: A0A8J8Y8C2
uniprot id: F7GGS2
names: Similarity
messages: Belongs to the SPSB family.

9544:CCDC172
gene id: 9544:CCDC172
uniprot id: F6W0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9544:SNTB2
gene id: 9544:SNTB2
uniprot id: F6TV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9544:TGFB1
gene id: 9544:TGFB1
uniprot id: F7HCV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9544:PAGE3
gene id: 9544:PAGE3
uniprot id: F6RHF3
names: Similarity
messages: Belongs to the GAGE family.

9544:CREB5
gene id: 9544:CREB5
uniprot id: A0A1D5QIA4
uniprot id: A0A1D5RAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9544:RAB21
gene id: 9544:RAB21
uniprot id: A0A1D5QIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

9544:TUBA8
gene id: 9544:TUBA8
uniprot id: F7FMA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9544:HCN4
gene id: 9544:HCN4
uniprot id: F6VXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9544:CYP1D1
gene id: 9544:CYP1D1
uniprot id: G4V3Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:CNIH4
gene id: 9544:CNIH4
uniprot id: A0A8J8XZX7
uniprot id: F6Y4D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:TMX2
gene id: 9544:TMX2
uniprot id: A0A1D5Q7I0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9544:GNMT
gene id: 9544:GNMT
uniprot id: A0A8J8XRQ8
uniprot id: F7CZP8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9544:TRAK2
gene id: 9544:TRAK2
uniprot id: A0A8J8XRN8
uniprot id: H9YWM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9544:ALCAM
gene id: 9544:ALCAM
uniprot id: A0A1D5R7P2
uniprot id: F7E9U2
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9544:DAO
gene id: 9544:DAO
uniprot id: G7N5E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9544:LIN7C
gene id: 9544:LIN7C
uniprot id: A0A8J8XAI2
uniprot id: H9YYJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9544:PJVK
gene id: 9544:PJVK
uniprot id: A0A8J8Y5Z7
uniprot id: G7N8E8
names: Similarity
messages: Belongs to the gasdermin family.

9544:NR1D2
gene id: 9544:NR1D2
uniprot id: H9EUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:CCDC124
gene id: 9544:CCDC124
uniprot id: A0A1D5QAG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9544:DOCK10
gene id: 9544:DOCK10
uniprot id: A0A1D5Q6G4
names: Similarity
messages: Belongs to the DOCK family.

9544:PPP1R21
gene id: 9544:PPP1R21
uniprot id: F6U8J0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9544:CACNB3
gene id: 9544:CACNB3
uniprot id: A0A1D5QUE5
uniprot id: A0A1D5RBY3
uniprot id: F6VB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9544:VAMP2
gene id: 9544:VAMP2
uniprot id: I0FJX6
uniprot id: Q9N0Y0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB. Interacts with WDFY2, PRKCZ and PRKCI. Forms a complex with WDFY2 and PRKCZ (By similarity). Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP. Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (By similarity). Interacts with PICALM. Interacts with alpha-synuclein/SNCA (By similarity). Interacts with STX3 (By similarity).
messages: Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
messages: synaptic vesicle membrane

9544:ZNF197
gene id: 9544:ZNF197
uniprot id: G7MIW1
uniprot id: H9ES79
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC705310
gene id: 9544:LOC705310
uniprot id: F6PTB1
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9544:LOC106995434
gene id: 9544:LOC106995434
uniprot id: A0A1D5QMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:FIGNL1
gene id: 9544:FIGNL1
uniprot id: G7MLA9
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:LOC702006
gene id: 9544:LOC702006
uniprot id: G7NSX8
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9544:HMBOX1
gene id: 9544:HMBOX1
uniprot id: F6VKU0
uniprot id: G7N0T3
uniprot id: H9EQB5
names: Subcellular Location Annotation
messages: Nucleus

9544:DYNC2LI1
gene id: 9544:DYNC2LI1
uniprot id: F7H0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9544:MKNK2
gene id: 9544:MKNK2
uniprot id: H9EP11
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:TSPAN11
gene id: 9544:TSPAN11
uniprot id: A0A8J8XNJ9
uniprot id: G7N6M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:UGT2B9*2
gene id: 9544:UGT2B9*2
uniprot id: Q9GLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:ZHX2
gene id: 9544:ZHX2
uniprot id: H9ERC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9544:HDAC7
gene id: 9544:HDAC7
uniprot id: H9Z9W8
uniprot id: H9Z9W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9544:LOC693330
gene id: 9544:LOC693330
uniprot id: F7CMX7
names: Similarity
messages: Belongs to the GAGE family.

9544:SLC1A4
gene id: 9544:SLC1A4
uniprot id: H9YXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9544:CIAO2A
gene id: 9544:CIAO2A
uniprot id: H9EP99
names: Similarity
messages: Belongs to the MIP18 family.

9544:SEMA4F
gene id: 9544:SEMA4F
uniprot id: A0A1D5QP56
uniprot id: A0A8J8YQR7
uniprot id: F7DBA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KEG06 p12
gene id: 9544:KEG06_p12
uniprot id: Q6IYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9544:LOC702712
gene id: 9544:LOC702712
uniprot id: A0A1D5QR05
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GRIA3
gene id: 9544:GRIA3
uniprot id: A0A5F7ZAW6
uniprot id: F7F735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:MYCBP
gene id: 9544:MYCBP
uniprot id: F7GS32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9544:IZUMO1
gene id: 9544:IZUMO1
uniprot id: A0A8J8Y0H1
uniprot id: F6XH82
names: Similarity
messages: Belongs to the Izumo family.

9544:BCL9L
gene id: 9544:BCL9L
uniprot id: A0A1D5R5B7
uniprot id: F7HLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9544:KCNA3
gene id: 9544:KCNA3
uniprot id: F6ZSH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:NSG2
gene id: 9544:NSG2
uniprot id: A0A8J8Y9G8
uniprot id: F7D2P5
names: Similarity
messages: Belongs to the NSG family.

9544:DPH6
gene id: 9544:DPH6
uniprot id: H9G1H7
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9544:A4GALT
gene id: 9544:A4GALT
uniprot id: G7N441
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9544:TMEM59L
gene id: 9544:TMEM59L
uniprot id: F6R206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:FAXC
gene id: 9544:FAXC
uniprot id: F6WV55
names: Similarity
messages: Belongs to the FAX family.

9544:SULT1C4
gene id: 9544:SULT1C4
uniprot id: A0A5F8AAB7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:MGAT4D
gene id: 9544:MGAT4D
uniprot id: A0A1D5REG9
uniprot id: F7HQA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:ST3GAL6
gene id: 9544:ST3GAL6
uniprot id: A0A5F8AA79
uniprot id: A0A8J8Y7R2
uniprot id: F6YSL0
uniprot id: F6YSN5
uniprot id: H9Z273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:ATP11A
gene id: 9544:ATP11A
uniprot id: A0A5F7ZT43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:NDUFAF2
gene id: 9544:NDUFAF2
uniprot id: A0A8J8XRE5
uniprot id: G7MTT6
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9544:ATIC
gene id: 9544:ATIC
uniprot id: G7N8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: Cytoplasm

9544:LDHD
gene id: 9544:LDHD
uniprot id: F7HT65
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9544:AFF2
gene id: 9544:AFF2
uniprot id: A0A1D5QWZ6
uniprot id: F6YQQ1
names: Similarity
messages: Belongs to the AF4 family.

9544:SLC6A6
gene id: 9544:SLC6A6
uniprot id: F7D2B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9544:PFKM
gene id: 9544:PFKM
uniprot id: A0A8J8YEJ0
uniprot id: F6WXR9
uniprot id: F6WXS8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC6A19
gene id: 9544:SLC6A19
uniprot id: F7GJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:DCTPP1
gene id: 9544:DCTPP1
uniprot id: A0A1D5QTQ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9544:SHOC2
gene id: 9544:SHOC2
uniprot id: H9ZDV6
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9544:DESI2
gene id: 9544:DESI2
uniprot id: F6XDR1
names: Similarity
messages: Belongs to the DeSI family.

9544:CCND3
gene id: 9544:CCND3
uniprot id: A0A8J8XIA9
uniprot id: I0FW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9544:CMTM6
gene id: 9544:CMTM6
uniprot id: F7BRV9
names: Subcellular Location Annotation
messages: Membrane

9544:RPS2
gene id: 9544:RPS2
uniprot id: A0A8J8XTU3
uniprot id: G7NQT9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

9544:MRPL22
gene id: 9544:MRPL22
uniprot id: G7MVQ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9544:UCHL5
gene id: 9544:UCHL5
uniprot id: A0A5F8ATR9
names: Similarity
messages: Belongs to the peptidase C12 family.

9544:TMEM45B
gene id: 9544:TMEM45B
uniprot id: A0A8J8YBE6
uniprot id: F6UKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9544:SEPTIN4
gene id: 9544:SEPTIN4
uniprot id: A0A8J8XB46
uniprot id: F6VBY7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9544:CDC5L
gene id: 9544:CDC5L
uniprot id: A0A8J8Y717
uniprot id: F7BX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

9544:CYBB
gene id: 9544:CYBB
uniprot id: A0A8J8YNE8
uniprot id: F6X7S5
names: Subcellular Location Annotation
messages: Membrane

9544:SLC12A9
gene id: 9544:SLC12A9
uniprot id: G7MNV9
uniprot id: I0FTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9544:BCL2L10
gene id: 9544:BCL2L10
uniprot id: F7H6U5
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:PPP5C
gene id: 9544:PPP5C
uniprot id: A0A5F7ZXV1
uniprot id: A0A8J8Y398
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9544:TRAPPC1
gene id: 9544:TRAPPC1
uniprot id: A0A8J8YC07
uniprot id: H9ENC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9544:C20H16orf87
gene id: 9544:C20H16orf87
uniprot id: F6UGW1
names: Similarity
messages: Belongs to the UPF0547 family.

9544:BEX4
gene id: 9544:BEX4
uniprot id: A0A8J8Y7P0
uniprot id: F6XJS0
names: Similarity
messages: Belongs to the BEX family.

9544:NCK1
gene id: 9544:NCK1
uniprot id: A0A8J8XHZ7
uniprot id: F7E0A3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9544:MAPT
gene id: 9544:MAPT
uniprot id: A0A5F8A774
uniprot id: F6R387
uniprot id: P57786
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in neurons.
messages: Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity).
messages: Membrane
messages: Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation at Ser-280 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C (By similarity).
messages: Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity).
messages: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
messages: Secreted
messages: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9544:PSMA4
gene id: 9544:PSMA4
uniprot id: A0A1D5QLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:FDPS
gene id: 9544:FDPS
uniprot id: F7FI27
uniprot id: H9YVT1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9544:TMED4
gene id: 9544:TMED4
uniprot id: A0A5F7Z9U6
uniprot id: A0A8J8XE77
uniprot id: F7H512
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ENPEP
gene id: 9544:ENPEP
uniprot id: A0A8J8XKV5
uniprot id: G7MTN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9544:CRYL1
gene id: 9544:CRYL1
uniprot id: A0A5F8A662
uniprot id: I2CU33
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9544:ICAM4
gene id: 9544:ICAM4
uniprot id: F7HJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9544:SLC34A3
gene id: 9544:SLC34A3
uniprot id: A0A5F8AJ48
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9544:LOC107000957
gene id: 9544:LOC107000957
uniprot id: F6VGX3
names: Similarity
messages: Belongs to the LCE family.

9544:ELF4
gene id: 9544:ELF4
uniprot id: F7F6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:KPNA2
gene id: 9544:KPNA2
uniprot id: F6VLU3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9544:SLC25A29
gene id: 9544:SLC25A29
uniprot id: H9FPS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:CXCR5
gene id: 9544:CXCR5
uniprot id: G7NCD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:CYP4F8
gene id: 9544:CYP4F8
uniprot id: F7GXR5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:CCN1
gene id: 9544:CCN1
uniprot id: A0A8J8YAB0
uniprot id: G7MHT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:GAR1
gene id: 9544:GAR1
uniprot id: A0A5K1VBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9544:STXBP5L
gene id: 9544:STXBP5L
uniprot id: H9EUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:OR4Q3
gene id: 9544:OR4Q3
uniprot id: A0A5F7Z7Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:THTPA
gene id: 9544:THTPA
uniprot id: A0A1D5QKN1
uniprot id: A0A8J8XDU1
uniprot id: F6XKY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9544:NAA25
gene id: 9544:NAA25
uniprot id: A0A8J8YE03
uniprot id: F6QVJ9
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9544:PLCD1
gene id: 9544:PLCD1
uniprot id: A0A8J8XPQ2
uniprot id: G7MJ18
uniprot id: I0FHZ5
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9544:KCNJ12
gene id: 9544:KCNJ12
uniprot id: A0A8J8XM50
uniprot id: F7GLZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9544:CDK16
gene id: 9544:CDK16
uniprot id: H9EMH6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:NLGN2
gene id: 9544:NLGN2
uniprot id: A0A5F8ABC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9544:IL36A
gene id: 9544:IL36A
uniprot id: F6SRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9544:EGFR
gene id: 9544:EGFR
uniprot id: P55245
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2. Forms a complex with CCDC88A/GIV (via SH2-like regions) and GNAI3 which leads to enhanced EGFR signaling and triggering of cell migration; binding to CCDC88A requires autophosphorylation of the EGFR C-terminal region, and ligand stimulation is required for recruitment of GNAI3 to the complex. Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through ELOC- and ELOB-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATXN2. Interacts with GAREM1. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Interacts with GPER1; the interaction occurs in an estrogen-dependent…
messages: Cell membrane
messages: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Hypothalamus.
messages: Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months).
messages: Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
messages: Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting (By similarity). Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Palmitoylated on Cys residues by ZDHHC20. Palmitoylation inhibits internalization after ligand binding, and increases the persistence of tyrosine-phosphorylated EGFR at the cell membrane. Palmitoylation increases the amplitude and duration of EGFR signaling.
messages: Phosphorylated on Tyr residues in response to EGF. Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
messages: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (By similarity).

9544:TMEM38A
gene id: 9544:TMEM38A
uniprot id: H9FZN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9544:POLR1B
gene id: 9544:POLR1B
uniprot id: F7A8N8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9544:RXRG
gene id: 9544:RXRG
uniprot id: A0A8J8YBP9
uniprot id: F7HDB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9544:CAT
gene id: 9544:CAT
uniprot id: F6PLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9544:ATP6V1B1
gene id: 9544:ATP6V1B1
uniprot id: A0A8J8YBY9
uniprot id: F6WPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9544:JUP
gene id: 9544:JUP
uniprot id: A0A8J8YGS1
uniprot id: G7NIJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9544:MAP1LC3B
gene id: 9544:MAP1LC3B
uniprot id: A0A5F7ZX57
uniprot id: I2CT89
names: Similarity
messages: Belongs to the ATG8 family.

9544:ARRB1
gene id: 9544:ARRB1
uniprot id: H9FUE7
uniprot id: H9FUE8
names: Similarity
messages: Belongs to the arrestin family.

9544:CPLX2
gene id: 9544:CPLX2
uniprot id: A0A8J8XJM8
uniprot id: H9EPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9544:DLG1
gene id: 9544:DLG1
uniprot id: A0A1D5RK14
uniprot id: H9ENR9
uniprot id: H9ENS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9544:FCGR3
gene id: 9544:FCGR3
uniprot id: A3RFZ7
names: Function
names: PTM
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G, to form a functional receptor complex. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (By similarity). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (By similarity). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (By similarity).
messages: Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG1 and IgG2.
messages: Lymphocytes and monocytes.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (PubMed:33208458). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity). Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:344…
messages: Secreted
messages: Three common alleles are identified in Indian-origin rhesus macaques: 3A:01, 3A:02 and 3A:03. These alleles display similar IgG responses.
messages: Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.

9544:ITPR1
gene id: 9544:ITPR1
uniprot id: F7FEF3
uniprot id: F7FEK8
uniprot id: H9FU38
uniprot id: H9FU40
uniprot id: H9YVN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9544:MFSD14B
gene id: 9544:MFSD14B
uniprot id: F7GRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9544:LIN7A
gene id: 9544:LIN7A
uniprot id: F7HGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9544:ASPN
gene id: 9544:ASPN
uniprot id: A0A8J8YB42
uniprot id: G7NF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9544:PDP2
gene id: 9544:PDP2
uniprot id: A0A8J8XKI8
uniprot id: F6VCV0
names: Similarity
messages: Belongs to the PP2C family.

9544:LOC699053
gene id: 9544:LOC699053
uniprot id: F7F2L7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:TLR5
gene id: 9544:TLR5
uniprot id: B3Y639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:UBE2D3
gene id: 9544:UBE2D3
uniprot id: F6URZ8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:GNA13
gene id: 9544:GNA13
uniprot id: H9EP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9544:TIMM8A
gene id: 9544:TIMM8A
uniprot id: F7BGN5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9544:TATDN3
gene id: 9544:TATDN3
uniprot id: A0A1D5QQ86
uniprot id: A0A8J8XKZ5
uniprot id: G7MEL3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9544:DNAJC2
gene id: 9544:DNAJC2
uniprot id: A0A8J8XA85
uniprot id: G7MM22
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

9544:UPF2
gene id: 9544:UPF2
uniprot id: A0A5K1V9Y6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:PDGFC
gene id: 9544:PDGFC
uniprot id: A0A5F8ASK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PAX8
gene id: 9544:PAX8
uniprot id: F6PPM6
names: Subcellular Location Annotation
messages: Nucleus

9544:ARL8A
gene id: 9544:ARL8A
uniprot id: H9Z596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9544:SSH3
gene id: 9544:SSH3
uniprot id: F7AK30
uniprot id: F7AK49
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9544:PEX2
gene id: 9544:PEX2
uniprot id: A0A5F7ZH32
uniprot id: A0A8J8YH91
uniprot id: G7MZL3
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9544:ISOC1
gene id: 9544:ISOC1
uniprot id: H9ESJ6
names: Similarity
messages: Belongs to the isochorismatase family.

9544:LOC706480
gene id: 9544:LOC706480
uniprot id: F7BMC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:P3H1
gene id: 9544:P3H1
uniprot id: F6YYY8
names: Similarity
messages: Belongs to the leprecan family.

9544:NCBP1
gene id: 9544:NCBP1
uniprot id: H9FUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9544:RIBC1
gene id: 9544:RIBC1
uniprot id: A0A1D5RL83
uniprot id: A0A8J8YNJ1
names: Similarity
messages: Belongs to the RIB43A family.

9544:LOC106995770
gene id: 9544:LOC106995770
uniprot id: I0FUI5
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9544:GYS2
gene id: 9544:GYS2
uniprot id: A0A5F7ZAH6
uniprot id: F7FTD2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9544:SOX14
gene id: 9544:SOX14
uniprot id: F7HQE3
names: Subcellular Location Annotation
messages: Nucleus

9544:RLN3
gene id: 9544:RLN3
uniprot id: A0A5F7ZQJ4
uniprot id: A2CHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:UTP23
gene id: 9544:UTP23
uniprot id: F6YGH7
names: Subcellular Location Annotation
messages: nucleolus

9544:RBPMS2
gene id: 9544:RBPMS2
uniprot id: F6ZBJ2
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ZNF483
gene id: 9544:ZNF483
uniprot id: A0A1D5RKV2
uniprot id: A0A8J8Y648
names: Subcellular Location Annotation
messages: Nucleus

9544:NDUFAF3
gene id: 9544:NDUFAF3
uniprot id: A0A8J8YNZ1
uniprot id: F6VXY8
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9544:APH1A
gene id: 9544:APH1A
uniprot id: A0A8J8XAV4
uniprot id: G7MDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9544:NPL
gene id: 9544:NPL
uniprot id: A0A1D5QL39
uniprot id: G7MF42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9544:MAPK4
gene id: 9544:MAPK4
uniprot id: I2CVP6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9544:CHAF1B
gene id: 9544:CHAF1B
uniprot id: H9YYW4
names: Subcellular Location Annotation
messages: Nucleus

9544:TTC27
gene id: 9544:TTC27
uniprot id: F7HF56
names: Similarity
messages: Belongs to the TTC27 family.

9544:CAPN5
gene id: 9544:CAPN5
uniprot id: F7EDU0
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:HNRNPA3
gene id: 9544:HNRNPA3
uniprot id: F7GPE1
names: Subcellular Location Annotation
messages: Nucleus

9544:PYCR1
gene id: 9544:PYCR1
uniprot id: A0A8J8YIN6
uniprot id: F6TMV9
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:PRPF4
gene id: 9544:PRPF4
uniprot id: F6TT47
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:PGAM2
gene id: 9544:PGAM2
uniprot id: A0A8J8XXV1
uniprot id: G7MLE5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9544:SLC30A5
gene id: 9544:SLC30A5
uniprot id: F7F761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9544:GSTO2
gene id: 9544:GSTO2
uniprot id: A0A8J8YR32
uniprot id: G7N132
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9544:MLN
gene id: 9544:MLN
uniprot id: O18811
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9544:BICD2
gene id: 9544:BICD2
uniprot id: F6QN54
uniprot id: H9FRX7
names: Similarity
messages: Belongs to the BicD family.

9544:TCP11L2
gene id: 9544:TCP11L2
uniprot id: F6S8U5
names: Similarity
messages: Belongs to the TCP11 family.

9544:GPC4
gene id: 9544:GPC4
uniprot id: A0A8J8YII9
uniprot id: G7NRL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9544:MAEA
gene id: 9544:MAEA
uniprot id: A0A1D5R235
uniprot id: F7HRR9
names: Subcellular Location Annotation
messages: Nucleus matrix
messages: nucleoplasm

9544:CCT8
gene id: 9544:CCT8
uniprot id: A0A1D5RFA5
uniprot id: H9Z4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: cilium basal body

9544:CCNO
gene id: 9544:CCNO
uniprot id: G7MTR5
names: Similarity
messages: Belongs to the cyclin family.

9544:ADNP
gene id: 9544:ADNP
uniprot id: A0A8J8Y0N2
uniprot id: I0FQC9
names: Subcellular Location Annotation
messages: Nucleus

9544:TAFA1
gene id: 9544:TAFA1
uniprot id: F6SYD9
names: Similarity
messages: Belongs to the TAFA family.

9544:PRDM4
gene id: 9544:PRDM4
uniprot id: A0A1D5REV3
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9544:C12H2orf88
gene id: 9544:C12H2orf88
uniprot id: A0A8J8YPY4
uniprot id: F7FC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9544:PLOD2
gene id: 9544:PLOD2
uniprot id: F6WSU7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9544:ADH6
gene id: 9544:ADH6
uniprot id: F6XW80
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9544:NEFL
gene id: 9544:NEFL
uniprot id: F7ED68
uniprot id: G8F1E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9544:UBE2S
gene id: 9544:UBE2S
uniprot id: F7G0V2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:RTRAF
gene id: 9544:RTRAF
uniprot id: A0A5F8A3H3
names: Similarity
messages: Belongs to the RTRAF family.

9544:PPM1L
gene id: 9544:PPM1L
uniprot id: A0A8J8XNU1
uniprot id: F7EXU3
names: Similarity
messages: Belongs to the PP2C family.

9544:MRGPRX3
gene id: 9544:MRGPRX3
uniprot id: Q2LL16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

9544:TP53INP2
gene id: 9544:TP53INP2
uniprot id: F7G5F0
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9544:LOC702145
gene id: 9544:LOC702145
uniprot id: F7HC70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PPARD
gene id: 9544:PPARD
uniprot id: A0A8J8YK55
uniprot id: G7MRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:GSTZ1
gene id: 9544:GSTZ1
uniprot id: F6PW84
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9544:ARHGEF9
gene id: 9544:ARHGEF9
uniprot id: A0A1D5QVN2
uniprot id: H9EPM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9544:TRAF2
gene id: 9544:TRAF2
uniprot id: A0A5F8ADX3
uniprot id: H9Z138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:SMC6
gene id: 9544:SMC6
uniprot id: A0A1D5Q104
names: Subcellular Location Annotation
messages: Chromosome

9544:WNT6
gene id: 9544:WNT6
uniprot id: A0A5F7ZJ63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:ITGB7
gene id: 9544:ITGB7
uniprot id: F7BVZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9544:PLSCR1
gene id: 9544:PLSCR1
uniprot id: H9ZA71
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9544:ANAPC13
gene id: 9544:ANAPC13
uniprot id: A0A8J8YFD1
uniprot id: F7ENP2
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9544:NOP53
gene id: 9544:NOP53
uniprot id: H9EWQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

9544:PTK7
gene id: 9544:PTK7
uniprot id: F7G413
names: Subcellular Location Annotation
messages: Membrane

9544:RELT
gene id: 9544:RELT
uniprot id: A0A8J8Y5M1
uniprot id: G7NEA1
names: Similarity
messages: Belongs to the RELT family.

9544:GRM5
gene id: 9544:GRM5
uniprot id: F6SR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:VSX2
gene id: 9544:VSX2
uniprot id: F7AP06
names: Subcellular Location Annotation
messages: Nucleus

9544:PLXNC1
gene id: 9544:PLXNC1
uniprot id: A0A1D5QHF5
uniprot id: F7E0G3
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MARVELD3
gene id: 9544:MARVELD3
uniprot id: A0A1D5QZA8
uniprot id: A0A5F7ZY42
names: Subcellular Location Annotation
messages: Membrane

9544:LOC716273
gene id: 9544:LOC716273
uniprot id: G7NE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:FER
gene id: 9544:FER
uniprot id: F7GUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9544:IL3
gene id: 9544:IL3
uniprot id: G7MTY2
uniprot id: P25140
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated T-cells, mast cells, natural killer cells.
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
messages: Monomer.
messages: Secreted
messages: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

9544:CDK14
gene id: 9544:CDK14
uniprot id: F6R2M2
uniprot id: F6UU74
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:COPS4
gene id: 9544:COPS4
uniprot id: A0A1D5Q7W7
uniprot id: A0A8J8YQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9544:SLC25A22
gene id: 9544:SLC25A22
uniprot id: H9FZW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:GPHA2
gene id: 9544:GPHA2
uniprot id: F6XYG4
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:UBALD2
gene id: 9544:UBALD2
uniprot id: F7EXU9
names: Similarity
messages: Belongs to the UBALD family.

9544:IL17A
gene id: 9544:IL17A
uniprot id: A0A8J8YJF1
uniprot id: F6T3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9544:TEK
gene id: 9544:TEK
uniprot id: G7NFP9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SLC35A5
gene id: 9544:SLC35A5
uniprot id: F7D791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9544:LRRC8A
gene id: 9544:LRRC8A
uniprot id: F7E1A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:MYC
gene id: 9544:MYC
uniprot id: B8XIA5
uniprot id: G7N040
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9544:GFOD2
gene id: 9544:GFOD2
uniprot id: F6RMP8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9544:EIF1B
gene id: 9544:EIF1B
uniprot id: A0A1D5R466
uniprot id: A0A8J8Y8K6
names: Similarity
messages: Belongs to the SUI1 family.

9544:CDK10
gene id: 9544:CDK10
uniprot id: A0A8J8YM25
uniprot id: G7NQA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:GPR137
gene id: 9544:GPR137
uniprot id: F6T263
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9544:NKX2-5
gene id: 9544:NKX2-5
uniprot id: A0A8J8YB00
uniprot id: G7MU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9544:B2M
gene id: 9544:B2M
uniprot id: G7MX75
uniprot id: Q6V7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9544:TACO1
gene id: 9544:TACO1
uniprot id: A0A8J8XJU5
uniprot id: F7GT53
uniprot id: I0FMW5
names: Similarity
messages: Belongs to the TACO1 family.

9544:APEH
gene id: 9544:APEH
uniprot id: F7G744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

9544:DUSP4
gene id: 9544:DUSP4
uniprot id: A0A8J8Y973
uniprot id: F7HKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9544:PIAS3
gene id: 9544:PIAS3
uniprot id: H9FNP4
names: Similarity
messages: Belongs to the PIAS family.

9544:DUSP3
gene id: 9544:DUSP3
uniprot id: F7C5I2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9544:MLH1
gene id: 9544:MLH1
uniprot id: H9FUL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9544:PDE1C
gene id: 9544:PDE1C
uniprot id: F7GTC5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:IGFBP3
gene id: 9544:IGFBP3
uniprot id: I0FH47
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MED20
gene id: 9544:MED20
uniprot id: G7MPA7
uniprot id: H9EMQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:PPP1R16A
gene id: 9544:PPP1R16A
uniprot id: F6TEI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:CRY2
gene id: 9544:CRY2
uniprot id: A0A8J8XJJ8
uniprot id: G7NDI0
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9544:LOC697943
gene id: 9544:LOC697943
uniprot id: A0A5F8A1L8
uniprot id: F6Z735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MS4A family.
messages: Belongs to the PLAC1 family.
messages: Secreted

9544:GRM7
gene id: 9544:GRM7
uniprot id: F6WXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:STK17B
gene id: 9544:STK17B
uniprot id: H9EW56
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:C7H15orf65
gene id: 9544:C7H15orf65
uniprot id: A0A8J8XP32
uniprot id: F7GSC2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9544:PPP1R1A
gene id: 9544:PPP1R1A
uniprot id: A0A8J8XGA7
uniprot id: F7H8B4
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9544:EEF1AKMT2
gene id: 9544:EEF1AKMT2
uniprot id: F6VWE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

9544:ENO4
gene id: 9544:ENO4
uniprot id: F6SSS8
names: Similarity
messages: Belongs to the enolase family.

9544:FIS1
gene id: 9544:FIS1
uniprot id: A0A8J8YT80
uniprot id: G7MNX3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9544:NIFK
gene id: 9544:NIFK
uniprot id: A0A8J8Y767
uniprot id: G7NB31
names: Subcellular Location Annotation
messages: nucleolus

9544:LACC1
gene id: 9544:LACC1
uniprot id: F6UMP1
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9544:EGFL8
gene id: 9544:EGFL8
uniprot id: G7MRM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:FAM118A
gene id: 9544:FAM118A
uniprot id: A0A8J8XT37
uniprot id: G7N469
names: Similarity
messages: Belongs to the FAM118 family.

9544:MED17
gene id: 9544:MED17
uniprot id: A0A8J8XS28
uniprot id: H9ETD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:CSNK2B
gene id: 9544:CSNK2B
uniprot id: G7MRJ2
uniprot id: H9ENN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9544:SUGT1
gene id: 9544:SUGT1
uniprot id: H9ERY9
names: Similarity
messages: Belongs to the SGT1 family.

9544:EOGT
gene id: 9544:EOGT
uniprot id: A0A8J8YA85
uniprot id: F7FX04
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9544:TP53INP1
gene id: 9544:TP53INP1
uniprot id: A0A8J8Y1G8
uniprot id: H9ZFI9
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9544:PLEKHO1
gene id: 9544:PLEKHO1
uniprot id: A0A5F7ZML8
uniprot id: F7GCA6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:TDRD7
gene id: 9544:TDRD7
uniprot id: H9EVV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9544:RAD50
gene id: 9544:RAD50
uniprot id: F7DGI4
uniprot id: H9FNF3
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9544:KCNK10
gene id: 9544:KCNK10
uniprot id: A0A8J8Y9I5
uniprot id: G7MYY4
uniprot id: H9FW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:GMDS
gene id: 9544:GMDS
uniprot id: F7GZ39
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9544:ZNF330
gene id: 9544:ZNF330
uniprot id: A0A1D5RKQ6
uniprot id: A0A8J8XTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9544:MOXD1
gene id: 9544:MOXD1
uniprot id: I2CTS5
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9544:TARBP2
gene id: 9544:TARBP2
uniprot id: G7N752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9544:ACTL7B
gene id: 9544:ACTL7B
uniprot id: A0A8J8Y5N5
uniprot id: F6TAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9544:RUNX3
gene id: 9544:RUNX3
uniprot id: H9ZEQ8
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9544:DGKE
gene id: 9544:DGKE
uniprot id: A0A8J8XNZ8
uniprot id: G7NHQ2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:SYNDIG1
gene id: 9544:SYNDIG1
uniprot id: A0A8J8XCP1
uniprot id: F7C805
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:CWF19L1
gene id: 9544:CWF19L1
uniprot id: A0A5F8AH68
uniprot id: F6X973
uniprot id: H9FWP3
names: Similarity
messages: Belongs to the CWF19 family.

9544:CCT5
gene id: 9544:CCT5
uniprot id: A0A1D5Q8I4
uniprot id: A0A8J8XLB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:PABPC1L
gene id: 9544:PABPC1L
uniprot id: F6XFC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:MED26
gene id: 9544:MED26
uniprot id: A0A1D5QHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9544:LDB1
gene id: 9544:LDB1
uniprot id: H9G1C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9544:GRM2
gene id: 9544:GRM2
uniprot id: A0A8J8YHU3
uniprot id: F7H091
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:TDO2
gene id: 9544:TDO2
uniprot id: F6RBA2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CHDH
gene id: 9544:CHDH
uniprot id: A0A8J8XCQ5
uniprot id: F6SIV5
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9544:HBQ1
gene id: 9544:HBQ1
uniprot id: A0A140TAV0
names: Similarity
messages: Belongs to the globin family.

9544:TAAR3
gene id: 9544:TAAR3
uniprot id: D2X5R0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:P2RY1
gene id: 9544:P2RY1
uniprot id: A0A8J8XZQ6
uniprot id: F6V1F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:EXO5
gene id: 9544:EXO5
uniprot id: A0A8J8Y6M5
uniprot id: F6U8T1
names: Similarity
messages: Belongs to the EXO5 family.

9544:ZDHHC6
gene id: 9544:ZDHHC6
uniprot id: G7N153
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:LOC706568
gene id: 9544:LOC706568
uniprot id: A0A5F7ZPE7
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:RBL2
gene id: 9544:RBL2
uniprot id: A0A1D5QDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9544:STX1A
gene id: 9544:STX1A
uniprot id: Q9N0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9544:EPC2
gene id: 9544:EPC2
uniprot id: A0A5F8APM0
uniprot id: A0A8J8XY15
uniprot id: G7N818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9544:PRDX1
gene id: 9544:PRDX1
uniprot id: A0A8J8YHI3
uniprot id: G7MGP8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9544:VRTN
gene id: 9544:VRTN
uniprot id: A0A8J8XKL1
uniprot id: F7APM8
names: Similarity
messages: Belongs to the vertnin family.

9544:RPS6KA2
gene id: 9544:RPS6KA2
uniprot id: A0A1D5QGV7
uniprot id: H9FY70
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:CUL3
gene id: 9544:CUL3
uniprot id: F6R900
uniprot id: G7N924
names: Similarity
messages: Belongs to the cullin family.

9544:SLC34A2
gene id: 9544:SLC34A2
uniprot id: G7MSP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9544:PCSK2
gene id: 9544:PCSK2
uniprot id: F7GNE5
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:PATL1
gene id: 9544:PATL1
uniprot id: A0A5F7ZUV1
names: Similarity
messages: Belongs to the PAT1 family.

9544:MDM1
gene id: 9544:MDM1
uniprot id: G7N7L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9544:TMEM144
gene id: 9544:TMEM144
uniprot id: A0A8J8YT51
uniprot id: F7GN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9544:MARK1
gene id: 9544:MARK1
uniprot id: F6X788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9544:SLC35E2B
gene id: 9544:SLC35E2B
uniprot id: A0A5K1VRI8
uniprot id: F7G9G7
names: Subcellular Location Annotation
messages: Membrane

9544:TBCB
gene id: 9544:TBCB
uniprot id: H9EMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9544:ZFYVE9
gene id: 9544:ZFYVE9
uniprot id: F7D4F7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9544:LETMD1
gene id: 9544:LETMD1
uniprot id: F7FK68
names: Subcellular Location Annotation
messages: Membrane

9544:PLA2G12A
gene id: 9544:PLA2G12A
uniprot id: A0A8J8YK83
uniprot id: H9ER16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9544:MAP4K2
gene id: 9544:MAP4K2
uniprot id: H9ETH7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9544:C6H5orf22
gene id: 9544:C6H5orf22
uniprot id: G7MV16
names: Similarity
messages: Belongs to the UPF0489 family.

9544:CENPH
gene id: 9544:CENPH
uniprot id: G7MU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9544:CUL4B
gene id: 9544:CUL4B
uniprot id: A0A1D5QSY5
uniprot id: G7NRB7
names: Similarity
messages: Belongs to the cullin family.

9544:METTL3
gene id: 9544:METTL3
uniprot id: A0A8J8YGJ7
uniprot id: G7MWT2
names: Similarity
messages: Belongs to the MT-A70-like family.

9544:DAG1
gene id: 9544:DAG1
uniprot id: F6RU72
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9544:ZNF24
gene id: 9544:ZNF24
uniprot id: A0A8J8XDA5
uniprot id: F7HLR2
names: Subcellular Location Annotation
messages: Nucleus

9544:ATRAID
gene id: 9544:ATRAID
uniprot id: F6PVQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CRYBA1
gene id: 9544:CRYBA1
uniprot id: A0A8J8XG60
uniprot id: F6T4W0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:ST8SIA4
gene id: 9544:ST8SIA4
uniprot id: A0A8J8YQ45
uniprot id: G7MVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:RRAGB
gene id: 9544:RRAGB
uniprot id: A0A8J8XQU3
uniprot id: H9EU56
uniprot id: H9EUC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9544:OR5M9
gene id: 9544:OR5M9
uniprot id: A0A1D5Q7Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TSPAN6
gene id: 9544:TSPAN6
uniprot id: H9EV87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:FSCN1
gene id: 9544:FSCN1
uniprot id: F7EX32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9544:POLR3C
gene id: 9544:POLR3C
uniprot id: A0A8J8XXY4
uniprot id: G7MG22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:FES
gene id: 9544:FES
uniprot id: A0A8J8XB40
uniprot id: G7MVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9544:FOXP1
gene id: 9544:FOXP1
uniprot id: G1K374
names: Subcellular Location Annotation
messages: Nucleus

9544:SLCO2B1
gene id: 9544:SLCO2B1
uniprot id: H9Z4X7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SFMBT1
gene id: 9544:SFMBT1
uniprot id: A0A5F8A9B8
names: Subcellular Location Annotation
messages: Nucleus

9544:DYNLT3
gene id: 9544:DYNLT3
uniprot id: F6X6W3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9544:RNF2
gene id: 9544:RNF2
uniprot id: H9FY38
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9544:TMEM256
gene id: 9544:TMEM256
uniprot id: F6SZ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9544:SSR3
gene id: 9544:SSR3
uniprot id: H9YW96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9544:SLC9B2
gene id: 9544:SLC9B2
uniprot id: F6QDX3
names: Subcellular Location Annotation
messages: Membrane

9544:SLC9A6
gene id: 9544:SLC9A6
uniprot id: F6WNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9544:MED6
gene id: 9544:MED6
uniprot id: A0A8J8XKU8
uniprot id: G7MYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9544:FDFT1
gene id: 9544:FDFT1
uniprot id: A0A5F7Z7X6
uniprot id: A0A8J8YAZ6
uniprot id: H9EUN1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9544:RAB32
gene id: 9544:RAB32
uniprot id: F7H6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9544:CACTIN
gene id: 9544:CACTIN
uniprot id: F6YGQ7
uniprot id: H9ZBV6
names: Similarity
messages: Belongs to the CACTIN family.

9544:LOC704994
gene id: 9544:LOC704994
uniprot id: F7BRH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MRPS33
gene id: 9544:MRPS33
uniprot id: A0A8J8YFY1
uniprot id: F7HBG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9544:CORO1B
gene id: 9544:CORO1B
uniprot id: A0A8J8Y5A8
uniprot id: G7NBX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.
messages: stress fiber

9544:RNF121
gene id: 9544:RNF121
uniprot id: G7NE82
names: Subcellular Location Annotation
messages: Membrane

9544:SLC28A3
gene id: 9544:SLC28A3
uniprot id: A0A8J8XSS0
uniprot id: F7EYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9544:IGFBP4
gene id: 9544:IGFBP4
uniprot id: F7HF07
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:ETFRF1
gene id: 9544:ETFRF1
uniprot id: H9ENS3
names: Similarity
messages: Belongs to the complex I LYR family.

9544:KCTD6
gene id: 9544:KCTD6
uniprot id: A0A8J8XPG1
uniprot id: G7MKZ6
names: Subcellular Location Annotation
messages: Cell membrane

9544:LAD1
gene id: 9544:LAD1
uniprot id: A0A1D5QW47
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

9544:F2RL2
gene id: 9544:F2RL2
uniprot id: F6U5U6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:TYRO3
gene id: 9544:TYRO3
uniprot id: F6T717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9544:COPG2
gene id: 9544:COPG2
uniprot id: A0A5F7ZZL7
uniprot id: F6S6K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9544:MINDY3
gene id: 9544:MINDY3
uniprot id: A0A5F7ZVR7
uniprot id: A0A8J8XAR7
uniprot id: F7GVK3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9544:GTF2E1
gene id: 9544:GTF2E1
uniprot id: F7HTP8
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9544:SET
gene id: 9544:SET
uniprot id: H9YY26
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:SPG21
gene id: 9544:SPG21
uniprot id: A0A1D5QGQ8
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9544:MIEF1
gene id: 9544:MIEF1
uniprot id: F7GFQ1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9544:MPDU1
gene id: 9544:MPDU1
uniprot id: F6ZDI5
uniprot id: G7NIG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9544:PARD6B
gene id: 9544:PARD6B
uniprot id: I0FVR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9544:LOC708899
gene id: 9544:LOC708899
uniprot id: A0A8J8Y3X7
uniprot id: F7FLX7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SPSB4
gene id: 9544:SPSB4
uniprot id: A0A8J8YHQ2
uniprot id: F7G521
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9544:ABCD1
gene id: 9544:ABCD1
uniprot id: F7ENC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9544:OXER1
gene id: 9544:OXER1
uniprot id: A0A8J8XLH6
uniprot id: F6X8C7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:RNF152
gene id: 9544:RNF152
uniprot id: A0A1D5R8J4
uniprot id: A0A8J8XI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9544:TBXA2R
gene id: 9544:TBXA2R
uniprot id: F6VZF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:KDELR3
gene id: 9544:KDELR3
uniprot id: I0FNT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CORO1C
gene id: 9544:CORO1C
uniprot id: F6UBA0
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:SIVA1
gene id: 9544:SIVA1
uniprot id: A0A8J8Y771
uniprot id: F6RCS3
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9544:CENPM
gene id: 9544:CENPM
uniprot id: A0A1D5RDD8
uniprot id: A0A8J8XEZ1
names: Subcellular Location Annotation
messages: Nucleus

9544:LBH
gene id: 9544:LBH
uniprot id: H9YVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9544:LOC716188
gene id: 9544:LOC716188
uniprot id: F7BTR7
names: Similarity
messages: Belongs to the NipSnap family.

9544:SDF4
gene id: 9544:SDF4
uniprot id: H9FVA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9544:SLC50A1
gene id: 9544:SLC50A1
uniprot id: A0A8J8XLQ7
uniprot id: F6TTJ4
uniprot id: F6X7V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9544:CHRNB3
gene id: 9544:CHRNB3
uniprot id: A0A8J8XL00
uniprot id: G7MZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:ADGRL1
gene id: 9544:ADGRL1
uniprot id: H9EMJ3
uniprot id: H9EMJ4
uniprot id: H9Z6G5
names: Subcellular Location Annotation
messages: Membrane

9544:SLC30A7
gene id: 9544:SLC30A7
uniprot id: A0A8J8XUW6
uniprot id: G7MI63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9544:CAPN3
gene id: 9544:CAPN3
uniprot id: F7G923
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9544:RGS14
gene id: 9544:RGS14
uniprot id: H9FNV6
names: Subcellular Location Annotation
messages: dendrite

9544:KIF9
gene id: 9544:KIF9
uniprot id: G7MIR9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:DBP
gene id: 9544:DBP
uniprot id: A0A1D5QPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9544:CLTRN
gene id: 9544:CLTRN
uniprot id: A0A8J8XSN0
uniprot id: F7AH22
names: Subcellular Location Annotation
messages: Membrane

9544:ASB12
gene id: 9544:ASB12
uniprot id: A0A8J8YSY1
uniprot id: G7NRR5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:B3GALT4
gene id: 9544:B3GALT4
uniprot id: H9ZES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:BET1
gene id: 9544:BET1
uniprot id: F6UL51
names: Subcellular Location Annotation
messages: Membrane

9544:FEN1
gene id: 9544:FEN1
uniprot id: A0A8J8YHT0
uniprot id: F7H3Z6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9544:LIMD1
gene id: 9544:LIMD1
uniprot id: G7MIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

9544:GFM1
gene id: 9544:GFM1
uniprot id: F6UK19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9544:IFT20
gene id: 9544:IFT20
uniprot id: A0A8J8YQ27
uniprot id: F6STP2
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9544:LYPLAL1
gene id: 9544:LYPLAL1
uniprot id: F7CPP0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:NOX4
gene id: 9544:NOX4
uniprot id: A0A1D5RB90
uniprot id: F6WZN5
names: Subcellular Location Annotation
messages: Membrane

9544:FAM221A
gene id: 9544:FAM221A
uniprot id: F7EF41
names: Similarity
messages: Belongs to the FAM221 family.

9544:SH3BP5
gene id: 9544:SH3BP5
uniprot id: A0A8J8YHI1
uniprot id: G7MJV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9544:TM7SF3
gene id: 9544:TM7SF3
uniprot id: G7N6L0
names: Subcellular Location Annotation
messages: Membrane

9544:DLK1
gene id: 9544:DLK1
uniprot id: A0A5F8AFZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MTCP1
gene id: 9544:MTCP1
uniprot id: A0A8J8Y007
uniprot id: F6QM31
names: Similarity
messages: Belongs to the TCL1 family.

9544:ZDHHC14
gene id: 9544:ZDHHC14
uniprot id: F7C1L0
uniprot id: H9FZU9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:RPL10
gene id: 9544:RPL10
uniprot id: F7GKJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9544:CCZ1
gene id: 9544:CCZ1
uniprot id: H9H486
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9544:CCNT2
gene id: 9544:CCNT2
uniprot id: A0A5F8AD31
uniprot id: A0A8J8XYP7
uniprot id: F6SJ63
names: Similarity
messages: Belongs to the cyclin family.

9544:OXTR
gene id: 9544:OXTR
uniprot id: P56494
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9544:MRPS18C
gene id: 9544:MRPS18C
uniprot id: A0A5S6R9X2
uniprot id: G8F181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9544:ACMSD
gene id: 9544:ACMSD
uniprot id: A0A8J8XTJ2
uniprot id: F6SQ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9544:EP300
gene id: 9544:EP300
uniprot id: A0A5F7ZS56
uniprot id: A0A5F8AFL2
uniprot id: A0A8J8YH29
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LRP10
gene id: 9544:LRP10
uniprot id: A0A8J8Y1D2
uniprot id: G7MX26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC35D1
gene id: 9544:SLC35D1
uniprot id: F6XS30
names: Subcellular Location Annotation
messages: Membrane

9544:NMNAT3
gene id: 9544:NMNAT3
uniprot id: A0A1D5RBH7
uniprot id: A0A8J8Y0F2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9544:ILF3
gene id: 9544:ILF3
uniprot id: F7FLD2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:UBA1
gene id: 9544:UBA1
uniprot id: A0A5F8A1T9
uniprot id: F7HPQ2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9544:SLC31A1
gene id: 9544:SLC31A1
uniprot id: A0A8J8Y820
uniprot id: F6USX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9544:ALX3
gene id: 9544:ALX3
uniprot id: A0A5F8A5I7
names: Subcellular Location Annotation
messages: Nucleus

9544:IDS
gene id: 9544:IDS
uniprot id: H9FTX2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:CBX7
gene id: 9544:CBX7
uniprot id: F7BE16
uniprot id: H9FS56
names: Subcellular Location Annotation
messages: Nucleus

9544:ISY1
gene id: 9544:ISY1
uniprot id: A0A1D5QH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9544:UTP14A
gene id: 9544:UTP14A
uniprot id: A0A1D5QIB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9544:MED8
gene id: 9544:MED8
uniprot id: A0A1D5QAX8
uniprot id: A0A5K1VQ76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:VPS29
gene id: 9544:VPS29
uniprot id: F7H8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9544:SMIM8
gene id: 9544:SMIM8
uniprot id: F7ABF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9544:SUGP1
gene id: 9544:SUGP1
uniprot id: F6ZCX1
uniprot id: H9ERV6
names: Subcellular Location Annotation
messages: Nucleus

9544:AJAP1
gene id: 9544:AJAP1
uniprot id: F7ERB1
names: Subcellular Location Annotation
messages: Membrane

9544:SARS2
gene id: 9544:SARS2
uniprot id: H9EXI9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9544:UQCRQ
gene id: 9544:UQCRQ
uniprot id: A0A8J8XNU9
uniprot id: F6RLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9544:RABGGTA
gene id: 9544:RABGGTA
uniprot id: H9ER04
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9544:SGCE
gene id: 9544:SGCE
uniprot id: A0A5F7ZVW5
uniprot id: H9G1E8
uniprot id: I0FW55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9544:KIF11
gene id: 9544:KIF11
uniprot id: F7FKH9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:TENT5D
gene id: 9544:TENT5D
uniprot id: A0A8J8Y0V1
uniprot id: F6UZX0
names: Similarity
messages: Belongs to the TENT family.

9544:SNAP47
gene id: 9544:SNAP47
uniprot id: A0A8J8Y968
uniprot id: F7GP77
names: Similarity
messages: Belongs to the SVAP1 family.

9544:USP14
gene id: 9544:USP14
uniprot id: A0A1D5QG07
uniprot id: F7AFL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9544:PCNA
gene id: 9544:PCNA
uniprot id: F6ZD63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9544:IRF9
gene id: 9544:IRF9
uniprot id: A0A8J8YMM8
uniprot id: G7MX63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:ATP2A2
gene id: 9544:ATP2A2
uniprot id: H9FUZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:TAS2R13
gene id: 9544:TAS2R13
uniprot id: Q645T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:CSH3
gene id: 9544:CSH3
uniprot id: Q1L7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9544:TNR
gene id: 9544:TNR
uniprot id: A0A8J8YJC4
uniprot id: H9ER94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9544:GPR34
gene id: 9544:GPR34
uniprot id: F6ZED1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:FECH
gene id: 9544:FECH
uniprot id: H9ERE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9544:HMCES
gene id: 9544:HMCES
uniprot id: A0A1D5RJG4
uniprot id: A0A5F7ZE81
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9544:PAX3
gene id: 9544:PAX3
uniprot id: A0A1D5QPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9544:PLP2
gene id: 9544:PLP2
uniprot id: A0A8J8XRA5
uniprot id: G7NR93
names: Subcellular Location Annotation
messages: Membrane

9544:CSNK1G3
gene id: 9544:CSNK1G3
uniprot id: H9YX23
uniprot id: I0FHH4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9544:OR52W1
gene id: 9544:OR52W1
uniprot id: A0A8J8XCS3
uniprot id: F6Q2A2
names: Subcellular Location Annotation
messages: Membrane

9544:SLC39A9
gene id: 9544:SLC39A9
uniprot id: A0A8J8XZ71
uniprot id: F7EDB3
uniprot id: F7EDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9544:LOC699231
gene id: 9544:LOC699231
uniprot id: F6QAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:CFB
gene id: 9544:CFB
uniprot id: F6YJY7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MNAT1
gene id: 9544:MNAT1
uniprot id: A0A8J8YFJ4
uniprot id: H9EPT3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9544:POLR2F
gene id: 9544:POLR2F
uniprot id: A0A8J8Y8A3
uniprot id: G7N3U0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9544:IL1F10
gene id: 9544:IL1F10
uniprot id: A0A5F8AFW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9544:LEAP2
gene id: 9544:LEAP2
uniprot id: Q95M25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9544:TP63
gene id: 9544:TP63
uniprot id: A0A8J8YAQ1
uniprot id: F7FN59
uniprot id: F7FN64
uniprot id: F7GBG3
uniprot id: F7GBG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9544:GABARAPL2
gene id: 9544:GABARAPL2
uniprot id: A0A8J8YM91
uniprot id: F6W1M5
names: Similarity
messages: Belongs to the ATG8 family.

9544:VIPR1
gene id: 9544:VIPR1
uniprot id: A0A1D5R219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9544:CCT3
gene id: 9544:CCT3
uniprot id: A0A8J8YP63
uniprot id: G7MDZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:GSTK1
gene id: 9544:GSTK1
uniprot id: I0FRI5
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9544:LOC722074
gene id: 9544:LOC722074
uniprot id: F6SYX2
names: Similarity
messages: Belongs to the SCO1/2 family.

9544:DNAJC16
gene id: 9544:DNAJC16
uniprot id: A0A8J8XWS2
uniprot id: F7FND7
names: Subcellular Location Annotation
messages: Membrane

9544:AFG1L
gene id: 9544:AFG1L
uniprot id: G7MQY9
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9544:GNAI1
gene id: 9544:GNAI1
uniprot id: H9EPA7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:PLPP4
gene id: 9544:PLPP4
uniprot id: H9FQX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:CCT8L2
gene id: 9544:CCT8L2
uniprot id: A0A8J8XNY9
uniprot id: G7MNI7
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

9544:CALHM2
gene id: 9544:CALHM2
uniprot id: A0A8J8XP61
uniprot id: F7EXA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9544:LOC713408
gene id: 9544:LOC713408
uniprot id: F6VNG0
names: Similarity
messages: Belongs to the LCE family.

9544:LCMT1
gene id: 9544:LCMT1
uniprot id: F6RCY5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9544:NXPH3
gene id: 9544:NXPH3
uniprot id: F7FIL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:C13H2orf40
gene id: 9544:C13H2orf40
uniprot id: A0A8J8YAF3
uniprot id: G7NAV0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9544:ARG1
gene id: 9544:ARG1
uniprot id: A0A5F8AE86
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9544:PSMA2
gene id: 9544:PSMA2
uniprot id: A0A1D5QZ56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:LAMTOR2
gene id: 9544:LAMTOR2
uniprot id: F7H1L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9544:BARX2
gene id: 9544:BARX2
uniprot id: A0A8J8YMW1
uniprot id: F7BAQ7
names: Subcellular Location Annotation
messages: Nucleus

9544:KIF3B
gene id: 9544:KIF3B
uniprot id: A0A8J8YL95
uniprot id: F6S877
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:TAF9
gene id: 9544:TAF9
uniprot id: F7E5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9544:MS4A13
gene id: 9544:MS4A13
uniprot id: F6Q9F8
names: Similarity
messages: Belongs to the MS4A family.

9544:ZPR1
gene id: 9544:ZPR1
uniprot id: A0A5K1UBM7
names: Similarity
messages: Belongs to the ZPR1 family.

9544:ISL2
gene id: 9544:ISL2
uniprot id: A0A5F7ZE39
names: Subcellular Location Annotation
messages: Nucleus

9544:ADORA2A
gene id: 9544:ADORA2A
uniprot id: A0A8J8Y411
uniprot id: F6X9C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9544:DIPK1B
gene id: 9544:DIPK1B
uniprot id: A0A5F8AIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9544:DHX8
gene id: 9544:DHX8
uniprot id: A0A1D5QP06
names: Subcellular Location Annotation
messages: Nucleus

9544:PEPD
gene id: 9544:PEPD
uniprot id: G7NLG9
names: Similarity
messages: Belongs to the peptidase M24B family.

9544:TNFRSF9
gene id: 9544:TNFRSF9
uniprot id: A0A8J8YA70
uniprot id: F6W5G6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CHD1
gene id: 9544:CHD1
uniprot id: A0A1D5RAG7
names: Subcellular Location Annotation
messages: Nucleus

9544:MRPL51
gene id: 9544:MRPL51
uniprot id: F6ZY79
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9544:DPEP2
gene id: 9544:DPEP2
uniprot id: A0A8J8XBJ6
uniprot id: F7G4B5
names: Subcellular Location Annotation
messages: Membrane

9544:GGA2
gene id: 9544:GGA2
uniprot id: F7AF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9544:SGO1
gene id: 9544:SGO1
uniprot id: F7GJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9544:TNPO1
gene id: 9544:TNPO1
uniprot id: H9EQ61
uniprot id: H9EQ62
names: Subcellular Location Annotation
messages: Cytoplasm

9544:NPEPPS
gene id: 9544:NPEPPS
uniprot id: H9ZFL2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9544:OR10P1
gene id: 9544:OR10P1
uniprot id: G7N793
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:KIF3A
gene id: 9544:KIF3A
uniprot id: F7HNX9
uniprot id: H9FPA5
uniprot id: I2CTD3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:LRP3
gene id: 9544:LRP3
uniprot id: A0A1D5R1C6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NRCAM
gene id: 9544:NRCAM
uniprot id: F7HMK0
uniprot id: I2CTL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9544:HRH2
gene id: 9544:HRH2
uniprot id: I2CTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ADGRB2
gene id: 9544:ADGRB2
uniprot id: A0A1D5R177
uniprot id: F7FAA5
names: Subcellular Location Annotation
messages: Membrane

9544:KDM3A
gene id: 9544:KDM3A
uniprot id: F6ZGH6
names: Subcellular Location Annotation
messages: Nucleus

9544:GLT6D1
gene id: 9544:GLT6D1
uniprot id: G7NF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9544:ERP29
gene id: 9544:ERP29
uniprot id: F6QVU7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9544:NAT1
gene id: 9544:NAT1
uniprot id: A0A8J8Y431
uniprot id: F6Q3X1
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9544:MCM8
gene id: 9544:MCM8
uniprot id: F6RN32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:DES
gene id: 9544:DES
uniprot id: G7N901
names: Similarity
messages: Belongs to the intermediate filament family.

9544:ACTB
gene id: 9544:ACTB
uniprot id: F6TIK4
uniprot id: Q6RHR8
uniprot id: Q6UIS1
names: Similarity
messages: Belongs to the actin family.

9544:FAM199X
gene id: 9544:FAM199X
uniprot id: A0A8J8XTC2
uniprot id: H9FQ48
names: Similarity
messages: Belongs to the FAM199 family.

9544:RPN1
gene id: 9544:RPN1
uniprot id: Q3YAI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:GOSR2
gene id: 9544:GOSR2
uniprot id: H9FMZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9544:NRTN
gene id: 9544:NRTN
uniprot id: H9Z109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9544:NAP1L3
gene id: 9544:NAP1L3
uniprot id: F7DX32
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:LOC697687
gene id: 9544:LOC697687
uniprot id: A0A5F8AHA8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:GALR1
gene id: 9544:GALR1
uniprot id: A0A5F7ZRW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9544:MRPL50
gene id: 9544:MRPL50
uniprot id: A0A5F8A6B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9544:GNG5
gene id: 9544:GNG5
uniprot id: F6XHP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:ZNF449
gene id: 9544:ZNF449
uniprot id: A0A8J8YJH3
uniprot id: F7HIU7
names: Subcellular Location Annotation
messages: Nucleus

9544:PLPPR2
gene id: 9544:PLPPR2
uniprot id: G7NL25
uniprot id: H9FYI5
uniprot id: H9FYI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:DSE
gene id: 9544:DSE
uniprot id: A0A5F8AUJ6
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9544:RPL12
gene id: 9544:RPL12
uniprot id: A0A8J8XQZ9
uniprot id: F7AD35
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9544:LOC705696
gene id: 9544:LOC705696
uniprot id: A0A8J8Y4M6
uniprot id: G7NQG9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9544:YBEY
gene id: 9544:YBEY
uniprot id: F6S0T8
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9544:POLR3GL
gene id: 9544:POLR3GL
uniprot id: A0A8J8YI54
uniprot id: F6V5W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:OAS3
gene id: 9544:OAS3
uniprot id: A0A1D5QJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9544:SLC25A36
gene id: 9544:SLC25A36
uniprot id: H9EQZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:ATG4D
gene id: 9544:ATG4D
uniprot id: A0A5F8AE08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9544:EBF1
gene id: 9544:EBF1
uniprot id: A0A1D5R8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:CRISP3
gene id: 9544:CRISP3
uniprot id: G7MPJ5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ITGA3
gene id: 9544:ITGA3
uniprot id: A0A5F7ZAZ7
uniprot id: F7HLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:ASPDH
gene id: 9544:ASPDH
uniprot id: A0A1D5QVH6
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9544:DDAH1
gene id: 9544:DDAH1
uniprot id: F7HB67
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9544:ABCG5
gene id: 9544:ABCG5
uniprot id: G7N9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9544:SNX14
gene id: 9544:SNX14
uniprot id: F7GA99
uniprot id: H9YYU0
uniprot id: H9ZBK3
names: Similarity
messages: Belongs to the sorting nexin family.

9544:QRSL1
gene id: 9544:QRSL1
uniprot id: H9EVL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9544:SUPT5H
gene id: 9544:SUPT5H
uniprot id: F6XPK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9544:FBXO32
gene id: 9544:FBXO32
uniprot id: F7GVE8
names: Subcellular Location Annotation
messages: Nucleus

9544:BGLAP
gene id: 9544:BGLAP
uniprot id: A0A8J8Y2R9
uniprot id: A2D670
uniprot id: G7MDZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (By similarity).
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9544:SLA2
gene id: 9544:SLA2
uniprot id: A0A8J8XS58
uniprot id: G7N4X4
names: Subcellular Location Annotation
messages: Cytoplasm

9544:RNF111
gene id: 9544:RNF111
uniprot id: A0A5K1UP98
uniprot id: G7MXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9544:ACTR5
gene id: 9544:ACTR5
uniprot id: F7FIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

9544:PKN2
gene id: 9544:PKN2
uniprot id: F7C0E0
uniprot id: H9FX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9544:GALE
gene id: 9544:GALE
uniprot id: A0A8J8YKJ0
uniprot id: H9EVN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9544:SUSD6
gene id: 9544:SUSD6
uniprot id: A0A8J8XM14
uniprot id: G7MYI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ATP13A2
gene id: 9544:ATP13A2
uniprot id: F7GUW3
uniprot id: F7GUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9544:URGCP
gene id: 9544:URGCP
uniprot id: A0A1D5Q6P6
uniprot id: A0A1D5RA95
uniprot id: A0A5F7ZXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9544:MGAT2
gene id: 9544:MGAT2
uniprot id: A0A8J8XXU9
uniprot id: G7MXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9544:RAB3A
gene id: 9544:RAB3A
uniprot id: A0A1D5R9N2
uniprot id: A0A8J8YHR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9544:ADSS
gene id: 9544:ADSS
uniprot id: F7HTL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9544:ZNF202
gene id: 9544:ZNF202
uniprot id: I2CXM0
names: Subcellular Location Annotation
messages: Nucleus

9544:ZNF215
gene id: 9544:ZNF215
uniprot id: A0A8J8YFI9
uniprot id: F7H878
names: Subcellular Location Annotation
messages: Nucleus

9544:CACUL1
gene id: 9544:CACUL1
uniprot id: A0A8J8XDT5
uniprot id: I0FHI2
names: Similarity
messages: Belongs to the cullin family.

9544:MTMR11
gene id: 9544:MTMR11
uniprot id: F7BEA2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:SSTR3
gene id: 9544:SSTR3
uniprot id: F6XSK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC698928
gene id: 9544:LOC698928
uniprot id: A0A1D5QII1
names: Similarity
messages: Belongs to the GAGE family.

9544:TSSC4
gene id: 9544:TSSC4
uniprot id: A0A8J8YIA4
uniprot id: G7NBM2
names: Similarity
messages: Belongs to the TSSC4 family.

9544:CDH18
gene id: 9544:CDH18
uniprot id: A0A8J8XSY9
uniprot id: F7FMS7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:LOC718280
gene id: 9544:LOC718280
uniprot id: A0A8J8XWP1
uniprot id: F7HPR3
names: Similarity
messages: Belongs to the histone H3 family.

9544:PDE8A
gene id: 9544:PDE8A
uniprot id: F7FU86
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:EEF1D
gene id: 9544:EEF1D
uniprot id: F7GRR7
uniprot id: I0FPR4
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9544:NXPH1
gene id: 9544:NXPH1
uniprot id: A0A8J8XJZ9
uniprot id: G7MLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:LOC720791
gene id: 9544:LOC720791
uniprot id: A0A8J8XLR1
uniprot id: F7CA88
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9544:RPS27L
gene id: 9544:RPS27L
uniprot id: H9FV62
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9544:NSMCE4A
gene id: 9544:NSMCE4A
uniprot id: H9EVP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9544:CD34
gene id: 9544:CD34
uniprot id: A0A8J8YGY9
uniprot id: G7MEP4
names: Subcellular Location Annotation
messages: Membrane

9544:TSTA3
gene id: 9544:TSTA3
uniprot id: A0A8J8YDL3
uniprot id: F7FLX2
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9544:BTN1A1
gene id: 9544:BTN1A1
uniprot id: F6TI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9544:CXXC5
gene id: 9544:CXXC5
uniprot id: A0A8J8YJU6
uniprot id: F6TRL8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:DACT1
gene id: 9544:DACT1
uniprot id: F6QLT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9544:THAP1
gene id: 9544:THAP1
uniprot id: H9FWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9544:TRIQK
gene id: 9544:TRIQK
uniprot id: F7FFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CLPX
gene id: 9544:CLPX
uniprot id: A0A1D5RD00
names: Similarity
messages: Belongs to the ClpX chaperone family.

9544:SLC16A3
gene id: 9544:SLC16A3
uniprot id: A0A8J8YAG1
uniprot id: F6R637
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9544:ALG13
gene id: 9544:ALG13
uniprot id: A0A5F8ASN1
uniprot id: A0A8J8XWU6
uniprot id: H9YV14
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9544:BBS2
gene id: 9544:BBS2
uniprot id: G7NPC3
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9544:IL12RB2
gene id: 9544:IL12RB2
uniprot id: F6X0C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9544:CNGA4
gene id: 9544:CNGA4
uniprot id: F7BPP2
names: Subcellular Location Annotation
messages: Membrane

9544:POT1
gene id: 9544:POT1
uniprot id: F7C0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9544:EFNB2
gene id: 9544:EFNB2
uniprot id: F7HHG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GHITM
gene id: 9544:GHITM
uniprot id: F6YLT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:FERMT3
gene id: 9544:FERMT3
uniprot id: A0A5K1VG20
names: Similarity
messages: Belongs to the kindlin family.

9544:LOC717842
gene id: 9544:LOC717842
uniprot id: F6R281
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9544:PTGER4
gene id: 9544:PTGER4
uniprot id: F7FTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9544:LOC106995435
gene id: 9544:LOC106995435
uniprot id: A0A1D5R9Z1
names: Subcellular Location Annotation
messages: Nucleus

9544:SFXN3
gene id: 9544:SFXN3
uniprot id: A0A5F7ZU85
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9544:ZNF18
gene id: 9544:ZNF18
uniprot id: A0A8J8Y8T8
uniprot id: G7NIT3
names: Subcellular Location Annotation
messages: Nucleus

9544:KCNE3
gene id: 9544:KCNE3
uniprot id: A0A5F8ASP6
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9544:PLPP1
gene id: 9544:PLPP1
uniprot id: I2CT37
uniprot id: I2CTE1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9544:C15H9orf78
gene id: 9544:C15H9orf78
uniprot id: G8F1S9
uniprot id: H9YZC9
names: Similarity
messages: Belongs to the TLS1 family.

9544:ITPRIPL1
gene id: 9544:ITPRIPL1
uniprot id: A0A5K1TYG5
uniprot id: F7A9W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9544:DDX50
gene id: 9544:DDX50
uniprot id: A0A1D5QBU0
uniprot id: F6SQG1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9544:ORC6
gene id: 9544:ORC6
uniprot id: A0A1D5R5S3
uniprot id: A0A8J8XX90
uniprot id: F7HKI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9544:PARP6
gene id: 9544:PARP6
uniprot id: F7F0C5
uniprot id: H9EPD4
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:RNF13
gene id: 9544:RNF13
uniprot id: A0A1D5Q7Q2
uniprot id: H9ELX5
names: Subcellular Location Annotation
messages: Membrane

9544:POLR2K
gene id: 9544:POLR2K
uniprot id: F7FMW4
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9544:SLIT2
gene id: 9544:SLIT2
uniprot id: F7H9D1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:CRB1
gene id: 9544:CRB1
uniprot id: F7FIC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NR1D1
gene id: 9544:NR1D1
uniprot id: I2CUB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:LECT2
gene id: 9544:LECT2
uniprot id: A0A8J8XW89
uniprot id: F6VHJ2
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9544:HTR3A
gene id: 9544:HTR3A
uniprot id: F7ES27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9544:RAMP3
gene id: 9544:RAMP3
uniprot id: F7HCG7
names: Similarity
messages: Belongs to the RAMP family.

9544:GJD3
gene id: 9544:GJD3
uniprot id: F7FAS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:LOC701920
gene id: 9544:LOC701920
uniprot id: F6TWQ0
names: Similarity
messages: Belongs to the serpin family.

9544:LYPD2
gene id: 9544:LYPD2
uniprot id: A0A8J8XAM0
uniprot id: G7N074
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:NFU1
gene id: 9544:NFU1
uniprot id: G7NA86
uniprot id: H9ERP8
names: Similarity
messages: Belongs to the NifU family.

9544:SLC48A1
gene id: 9544:SLC48A1
uniprot id: F6YJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9544:CAVIN3
gene id: 9544:CAVIN3
uniprot id: H9Z4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9544:MARCH9
gene id: 9544:MARCH9
uniprot id: F6KMX0
names: Subcellular Location Annotation
messages: Membrane

9544:SNX9
gene id: 9544:SNX9
uniprot id: A0A5F8ANR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9544:AOC1
gene id: 9544:AOC1
uniprot id: F6TU01
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9544:EGR1
gene id: 9544:EGR1
uniprot id: F7FJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9544:MANBAL
gene id: 9544:MANBAL
uniprot id: A0A8J8XZF6
uniprot id: F7E8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9544:ANO3
gene id: 9544:ANO3
uniprot id: A0A8J8XZN3
uniprot id: G7NDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9544:PTGDR
gene id: 9544:PTGDR
uniprot id: F7HTJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:CSNK1E
gene id: 9544:CSNK1E
uniprot id: A0A8J8Y6F4
uniprot id: F6R2T7
uniprot id: F6R628
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:SCN1A
gene id: 9544:SCN1A
uniprot id: A0A1D5QX02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:TOMM22
gene id: 9544:TOMM22
uniprot id: F6YG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9544:BCKDK
gene id: 9544:BCKDK
uniprot id: A0A8J8YMC1
uniprot id: F7FRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:SMOC1
gene id: 9544:SMOC1
uniprot id: A0A1D5QP17
uniprot id: F7HPP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:AP1G2
gene id: 9544:AP1G2
uniprot id: A0A8J8XGJ3
uniprot id: F6XKB0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9544:BLCAP
gene id: 9544:BLCAP
uniprot id: A0A8J8XNI4
uniprot id: F7AJE1
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9544:GRIA1
gene id: 9544:GRIA1
uniprot id: A0A8J8YG09
uniprot id: G7MVP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:CDC26
gene id: 9544:CDC26
uniprot id: A0A8J8YSZ2
uniprot id: F6VD10
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9544:RDH12
gene id: 9544:RDH12
uniprot id: A0A8J8YMJ1
uniprot id: F7C217
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:GPSM1
gene id: 9544:GPSM1
uniprot id: I2CVY9
names: Similarity
messages: Belongs to the GPSM family.

9544:BOLA1
gene id: 9544:BOLA1
uniprot id: A0A8J8XFY7
uniprot id: F7FGU2
names: Similarity
messages: Belongs to the BolA/IbaG family.

9544:RGMB
gene id: 9544:RGMB
uniprot id: I2CTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9544:CENPL
gene id: 9544:CENPL
uniprot id: F6UIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9544:GHR
gene id: 9544:GHR
uniprot id: A0A1D5RFI9
uniprot id: P79194
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9544:GOLGA5
gene id: 9544:GOLGA5
uniprot id: H9ZG37
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9544:ALDOA
gene id: 9544:ALDOA
uniprot id: F6SYL4
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9544:CDK6
gene id: 9544:CDK6
uniprot id: A0A8J8YT09
uniprot id: H9EMN3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CYP3A5
gene id: 9544:CYP3A5
uniprot id: Q6GUQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:RAD9B
gene id: 9544:RAD9B
uniprot id: G7N5G9
names: Similarity
messages: Belongs to the rad9 family.

9544:IGF1
gene id: 9544:IGF1
uniprot id: A0A1D5Q6C0
uniprot id: F6W003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:ASB11
gene id: 9544:ASB11
uniprot id: A0A5F7ZSW9
uniprot id: A0A5F8A1F4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:PPP1R3C
gene id: 9544:PPP1R3C
uniprot id: F6XAD6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9544:MORF4L1
gene id: 9544:MORF4L1
uniprot id: F6VZK6
uniprot id: H9YYT5
names: Subcellular Location Annotation
messages: Nucleus

9544:ART4
gene id: 9544:ART4
uniprot id: G7N6E9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9544:HPD
gene id: 9544:HPD
uniprot id: A0A8J8YE92
uniprot id: F7GF23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9544:TVP23A
gene id: 9544:TVP23A
uniprot id: H9FZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9544:GPD2
gene id: 9544:GPD2
uniprot id: A0A1D5RJ98
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9544:NLRP2
gene id: 9544:NLRP2
uniprot id: B0FPF0
names: Similarity
messages: Belongs to the NLRP family.

9544:KCTD4
gene id: 9544:KCTD4
uniprot id: A0A8J8YLX8
uniprot id: F7F064
names: Subcellular Location Annotation
messages: Cell membrane

9544:GINS1
gene id: 9544:GINS1
uniprot id: G8F1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9544:THBS4
gene id: 9544:THBS4
uniprot id: F7EPG2
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC30A8
gene id: 9544:SLC30A8
uniprot id: A0A5F8AAT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

9544:FAM163A
gene id: 9544:FAM163A
uniprot id: A0A8J8YIK1
uniprot id: F6XKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9544:GC
gene id: 9544:GC
uniprot id: G7MT44
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9544:PLAU
gene id: 9544:PLAU
uniprot id: F6YDV7
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9544:TMEM41A
gene id: 9544:TMEM41A
uniprot id: A0A5F7ZNH4
uniprot id: A0A8J8XYX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9544:HSDL1
gene id: 9544:HSDL1
uniprot id: G7NPE7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:NFKBIL1
gene id: 9544:NFKBIL1
uniprot id: Q5TM19
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CACTIN (via N-terminal domain); the interaction occurs in a pro-inflammatory-independent manner.
messages: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity).
messages: Nucleus

9544:GRAMD1B
gene id: 9544:GRAMD1B
uniprot id: A0A1D5Q4J4
uniprot id: A0A1D5QTT7
uniprot id: H9FXM0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TBCC
gene id: 9544:TBCC
uniprot id: F7BNI0
uniprot id: G7MPC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9544:TUB
gene id: 9544:TUB
uniprot id: F6ZVE9
uniprot id: H9FZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9544:SLC17A8
gene id: 9544:SLC17A8
uniprot id: F6UIA5
names: Subcellular Location Annotation
messages: Membrane

9544:GJA5
gene id: 9544:GJA5
uniprot id: A0A8J8XQH8
uniprot id: F7GSB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:GTPBP10
gene id: 9544:GTPBP10
uniprot id: F7GZX5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9544:ZHX3
gene id: 9544:ZHX3
uniprot id: A0A5F7ZSW7
uniprot id: F7AY06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9544:OLFM2
gene id: 9544:OLFM2
uniprot id: A0A1D5QCB9
uniprot id: F6U4R3
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9544:EIF2S1
gene id: 9544:EIF2S1
uniprot id: A0A8J8XNQ0
uniprot id: F7EFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9544:HSDL2
gene id: 9544:HSDL2
uniprot id: A0A8J8XYT1
uniprot id: G7NEH8
names: Subcellular Location Annotation
messages: Peroxisome

9544:GNL1
gene id: 9544:GNL1
uniprot id: Q5TM59
names: Domain
names: Function
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: Possible regulatory or functional link with the histocompatibility cluster.

9544:TRAP1
gene id: 9544:TRAP1
uniprot id: F7EHQ6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9544:LOC693777
gene id: 9544:LOC693777
uniprot id: A0A5F7Z958
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:HSD17B11
gene id: 9544:HSD17B11
uniprot id: H9FVB1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:YPEL5
gene id: 9544:YPEL5
uniprot id: A0A8J8Y037
uniprot id: F6Y2U2
names: Similarity
messages: Belongs to the yippee family.

9544:NR0B1
gene id: 9544:NR0B1
uniprot id: A0A8J8YMH7
uniprot id: F7EIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9544:KATNA1
gene id: 9544:KATNA1
uniprot id: A0A8J8XH03
uniprot id: G7MQ57
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9544:XRN2
gene id: 9544:XRN2
uniprot id: H9FRE3
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9544:SERPINA5
gene id: 9544:SERPINA5
uniprot id: Q28500
names: Similarity
messages: Belongs to the serpin family.

9544:C8B
gene id: 9544:C8B
uniprot id: A0A1D5RJJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MAN2A1
gene id: 9544:MAN2A1
uniprot id: H9EVC7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9544:ACER1
gene id: 9544:ACER1
uniprot id: A0A8J8XX29
uniprot id: F6U4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9544:HMGCS1
gene id: 9544:HMGCS1
uniprot id: F7HQ90
uniprot id: G8F1C3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9544:EPGN
gene id: 9544:EPGN
uniprot id: A0A8J8Y2N5
uniprot id: F7AEA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SERPINB6
gene id: 9544:SERPINB6
uniprot id: A0A1D5QMN6
uniprot id: H9FVT9
names: Similarity
messages: Belongs to the serpin family.

9544:BIRC2
gene id: 9544:BIRC2
uniprot id: A0A8J8XPA8
uniprot id: H9EQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9544:SUPT4H1
gene id: 9544:SUPT4H1
uniprot id: A0A8J8XCI3
uniprot id: F6SS75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9544:MLF1
gene id: 9544:MLF1
uniprot id: H9FUL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9544:MCMBP
gene id: 9544:MCMBP
uniprot id: F6Y7L1
uniprot id: H9FZY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9544:RPL30
gene id: 9544:RPL30
uniprot id: F7GQT7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9544:ADGRL2
gene id: 9544:ADGRL2
uniprot id: H9FRW7
uniprot id: I0FGJ5
names: Subcellular Location Annotation
messages: Membrane

9544:KCTD9
gene id: 9544:KCTD9
uniprot id: F6QPZ2
names: Subcellular Location Annotation
messages: Cell membrane

9544:CAND1
gene id: 9544:CAND1
uniprot id: A0A8J8YMU0
uniprot id: H9EMN0
names: Similarity
messages: Belongs to the CAND family.

9544:MRPL10
gene id: 9544:MRPL10
uniprot id: H9FPU5
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9544:SLC25A12
gene id: 9544:SLC25A12
uniprot id: A0A1D5RFL8
uniprot id: F7F2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:PDIK1L
gene id: 9544:PDIK1L
uniprot id: A0A8J8XN47
uniprot id: G7MHQ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:LOC706213
gene id: 9544:LOC706213
uniprot id: A0A8J8XQI1
uniprot id: G7MFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CD6
gene id: 9544:CD6
uniprot id: H9ZFC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:IRX4
gene id: 9544:IRX4
uniprot id: F6Z379
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9544:SCOC
gene id: 9544:SCOC
uniprot id: A0A5F8AE96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9544:ESYT3
gene id: 9544:ESYT3
uniprot id: A0A8J8YM24
uniprot id: F7BWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PHKG1
gene id: 9544:PHKG1
uniprot id: A0A5K1UKE7
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9544:CDC25A
gene id: 9544:CDC25A
uniprot id: A0A1D5QME8
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9544:XK
gene id: 9544:XK
uniprot id: A0A5F7ZZM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9544:ARRDC4
gene id: 9544:ARRDC4
uniprot id: A0A5F8AI33
names: Similarity
messages: Belongs to the arrestin family.

9544:LOC705939
gene id: 9544:LOC705939
uniprot id: F7FXM2
names: Similarity
messages: Belongs to the intermediate filament family.

9544:GLRX
gene id: 9544:GLRX
uniprot id: F7GJV9
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9544:WDR24
gene id: 9544:WDR24
uniprot id: F6VA39
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

9544:ELP3
gene id: 9544:ELP3
uniprot id: A0A8J8XXU7
uniprot id: I0FGB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9544:ARL4C
gene id: 9544:ARL4C
uniprot id: A0A5K1UMB2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:CORO2A
gene id: 9544:CORO2A
uniprot id: G7NEY8
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:SAP30L
gene id: 9544:SAP30L
uniprot id: F7BKJ6
names: Similarity
messages: Belongs to the SAP30 family.

9544:LOC713600
gene id: 9544:LOC713600
uniprot id: A0A5F7ZWD1
names: Similarity
messages: Belongs to the LCE family.

9544:GRHL1
gene id: 9544:GRHL1
uniprot id: F6ZAV1
names: Subcellular Location Annotation
messages: Nucleus

9544:TTYH3
gene id: 9544:TTYH3
uniprot id: H9G053
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9544:CYB5R4
gene id: 9544:CYB5R4
uniprot id: A0A1D5REY0
uniprot id: A0A8J8YGS5
uniprot id: G7MPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9544:PPP4R2
gene id: 9544:PPP4R2
uniprot id: A0A1D5Q6P1
names: Similarity
messages: Belongs to the PPP4R2 family.

9544:WNT2
gene id: 9544:WNT2
uniprot id: A0A8J8XPN3
uniprot id: F7E738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:PRDX2
gene id: 9544:PRDX2
uniprot id: A0A8J8XBE4
uniprot id: G7NLB5
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9544:ZSCAN4
gene id: 9544:ZSCAN4
uniprot id: G7NP04
names: Subcellular Location Annotation
messages: Nucleus

9544:CLEC16A
gene id: 9544:CLEC16A
uniprot id: H9Z6X0
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9544:LOC100429959
gene id: 9544:LOC100429959
uniprot id: G7ND93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:USP30
gene id: 9544:USP30
uniprot id: A0A8J8XT20
uniprot id: F7DWK4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:DDX47
gene id: 9544:DDX47
uniprot id: A0A8J8YGA6
uniprot id: G7N685
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9544:ARRB2
gene id: 9544:ARRB2
uniprot id: A0A5F7ZE43
uniprot id: I0FK72
names: Similarity
messages: Belongs to the arrestin family.

9544:KLHL22
gene id: 9544:KLHL22
uniprot id: A0A8J8YHH4
uniprot id: H9G0X4
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

9544:MAGI3
gene id: 9544:MAGI3
uniprot id: F7DWC1
uniprot id: F7H7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:ARMC9
gene id: 9544:ARMC9
uniprot id: G7N951
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

9544:LMLN
gene id: 9544:LMLN
uniprot id: H9H2M5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9544:KCTD12
gene id: 9544:KCTD12
uniprot id: I2CWE4
names: Subcellular Location Annotation
messages: Cell membrane

9544:RPS25
gene id: 9544:RPS25
uniprot id: A0A5K1V1Q4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9544:POLA1
gene id: 9544:POLA1
uniprot id: A0A5F7ZAX4
uniprot id: H9ZA99
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9544:UTS2
gene id: 9544:UTS2
uniprot id: Q8HYC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Highly potent vasoconstrictor.
messages: Secreted

9544:NKX6-1
gene id: 9544:NKX6-1
uniprot id: F7H8N6
names: Subcellular Location Annotation
messages: Nucleus

9544:PHOX2B
gene id: 9544:PHOX2B
uniprot id: A0A5F7ZPS3
names: Subcellular Location Annotation
messages: Nucleus

9544:PFN2
gene id: 9544:PFN2
uniprot id: H9ENP0
uniprot id: H9ENP1
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

9544:MMACHC
gene id: 9544:MMACHC
uniprot id: A0A8J8Y077
uniprot id: H9EX34
names: Similarity
messages: Belongs to the MMACHC family.

9544:LOC704104
gene id: 9544:LOC704104
uniprot id: A0A8J8Y3X7
uniprot id: F7FLX7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:CCND2
gene id: 9544:CCND2
uniprot id: A0A8J8Y6N3
uniprot id: G7N5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9544:HARS2
gene id: 9544:HARS2
uniprot id: A0A8J8XK88
uniprot id: G7MUZ3
uniprot id: I2CY73
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9544:GPX5
gene id: 9544:GPX5
uniprot id: G7MRB6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9544:LOC709684
gene id: 9544:LOC709684
uniprot id: A0A5F8A1B3
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9544:MADD
gene id: 9544:MADD
uniprot id: I0FVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:LTB
gene id: 9544:LTB
uniprot id: Q5TM22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity).
messages: Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
messages: Membrane

9544:PRPS1L1
gene id: 9544:PRPS1L1
uniprot id: A0A5F8A181
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9544:ERBIN
gene id: 9544:ERBIN
uniprot id: F7GX50
uniprot id: F7GX54
uniprot id: F7GX57
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9544:VAMP7
gene id: 9544:VAMP7
uniprot id: A0A5F8A5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9544:RHCE
gene id: 9544:RHCE
uniprot id: Q28849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
messages: Membrane

9544:CD37
gene id: 9544:CD37
uniprot id: F6WD12
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:TRAPPC6B
gene id: 9544:TRAPPC6B
uniprot id: A0A1D5Q1H0
uniprot id: A0A8J8XUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9544:RPIA
gene id: 9544:RPIA
uniprot id: A0A8J8YSI6
uniprot id: F7H8C8
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9544:AKT3
gene id: 9544:AKT3
uniprot id: H9FNA9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9544:CCDC56
gene id: 9544:CCDC56
uniprot id: G7NIN2
uniprot id: I2CTG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9544:GLYCTK
gene id: 9544:GLYCTK
uniprot id: A0A8J8Y0Z7
uniprot id: G7MV99
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9544:LGI1
gene id: 9544:LGI1
uniprot id: A0A5F7ZTH0
uniprot id: A0A8J8YRR8
uniprot id: F7GS70
names: Subcellular Location Annotation
messages: Secreted

9544:CHAC2
gene id: 9544:CHAC2
uniprot id: A0A5F8A516
uniprot id: A0A8J8Y141
uniprot id: F7BCW7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9544:FYTTD1
gene id: 9544:FYTTD1
uniprot id: H9H359
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9544:TRAPPC3L
gene id: 9544:TRAPPC3L
uniprot id: F6SXJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9544:MAP2K1
gene id: 9544:MAP2K1
uniprot id: A0A8J8YDQ5
uniprot id: F7C389
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:ALDH6A1
gene id: 9544:ALDH6A1
uniprot id: F7E2B9
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9544:FAM207A
gene id: 9544:FAM207A
uniprot id: F7EKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9544:RIMKLA
gene id: 9544:RIMKLA
uniprot id: A0A8J8YR61
uniprot id: G7MGC4
names: Similarity
messages: Belongs to the RimK family.

9544:HLCS
gene id: 9544:HLCS
uniprot id: A0A5F7ZY99
uniprot id: H9EWC5
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9544:MEOX1
gene id: 9544:MEOX1
uniprot id: F6PKE6
names: Subcellular Location Annotation
messages: Nucleus

9544:AP1B1
gene id: 9544:AP1B1
uniprot id: A0A5K1VPP7
uniprot id: H9ETX7
uniprot id: H9FQM5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9544:RPS5
gene id: 9544:RPS5
uniprot id: A0A8J8XNQ1
uniprot id: F7HNZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9544:NOC4L
gene id: 9544:NOC4L
uniprot id: H9EX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9544:PPP1R2
gene id: 9544:PPP1R2
uniprot id: F6T1H7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9544:FAM216A
gene id: 9544:FAM216A
uniprot id: F6UJA4
names: Similarity
messages: Belongs to the FAM216 family.

9544:KEG06 p02
gene id: 9544:KEG06_p02
uniprot id: Q6IYG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9544:SNRPD3
gene id: 9544:SNRPD3
uniprot id: A0A8J8YDZ3
uniprot id: H9FYU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9544:SS18
gene id: 9544:SS18
uniprot id: A0A1D5R9F8
uniprot id: F7EQE4
names: Similarity
messages: Belongs to the SS18 family.

9544:MYBL2
gene id: 9544:MYBL2
uniprot id: A0A5K1UA99
names: Subcellular Location Annotation
messages: Nucleus

9544:ABRAXAS1
gene id: 9544:ABRAXAS1
uniprot id: H9ZEA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9544:BLOC1S2
gene id: 9544:BLOC1S2
uniprot id: A0A8J8XEG4
uniprot id: G7N0X2
uniprot id: H9EM67
names: Similarity
messages: Belongs to the BLOC1S2 family.

9544:CHPF
gene id: 9544:CHPF
uniprot id: H9ESG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:SSR1
gene id: 9544:SSR1
uniprot id: F6UGG4
uniprot id: H9ZCT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9544:SLC26A8
gene id: 9544:SLC26A8
uniprot id: G7MRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9544:ELMO2
gene id: 9544:ELMO2
uniprot id: A0A8J8XEX5
uniprot id: F6WWC5
uniprot id: I0FKS6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9544:STRIP2
gene id: 9544:STRIP2
uniprot id: F6TAH2
names: Similarity
messages: Belongs to the STRIP family.

9544:FEZ1
gene id: 9544:FEZ1
uniprot id: A0A1D5RD14
uniprot id: A0A8J8XCR2
names: Similarity
messages: Belongs to the zygin family.

9544:GFOD1
gene id: 9544:GFOD1
uniprot id: A0A8J8Y4D0
uniprot id: F7GT40
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9544:LOC704780
gene id: 9544:LOC704780
uniprot id: A0A5F8AS90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:IL17RB
gene id: 9544:IL17RB
uniprot id: A0A8J8YAC0
uniprot id: F7HL00
uniprot id: G7ML21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:STMN1
gene id: 9544:STMN1
uniprot id: A0A5F7ZEB3
uniprot id: I0FRN2
names: Similarity
messages: Belongs to the stathmin family.

9544:CCNB1
gene id: 9544:CCNB1
uniprot id: A0A8J8YEU8
uniprot id: F7GX97
names: Similarity
messages: Belongs to the cyclin family.

9544:DMBX1
gene id: 9544:DMBX1
uniprot id: F7G2L1
names: Subcellular Location Annotation
messages: Nucleus

9544:PPM1K
gene id: 9544:PPM1K
uniprot id: F6RY71
uniprot id: G8F1F4
names: Similarity
messages: Belongs to the PP2C family.

9544:UTP3
gene id: 9544:UTP3
uniprot id: G7MT50
names: Similarity
messages: Belongs to the SAS10 family.

9544:FICD
gene id: 9544:FICD
uniprot id: A0A8J8XFD5
uniprot id: F7H343
names: Similarity
messages: Belongs to the fic family.

9544:ZSCAN21
gene id: 9544:ZSCAN21
uniprot id: F7DPF1
names: Subcellular Location Annotation
messages: Nucleus

9544:TPT1
gene id: 9544:TPT1
uniprot id: F7HLW4
names: Similarity
messages: Belongs to the TCTP family.

9544:CERS2
gene id: 9544:CERS2
uniprot id: A0A8J8XJU3
uniprot id: F7BTU2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:LOC693785
gene id: 9544:LOC693785
uniprot id: A0A1D5R8C3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:BRINP3
gene id: 9544:BRINP3
uniprot id: H9EQG6
names: Similarity
messages: Belongs to the BRINP family.

9544:MCM5
gene id: 9544:MCM5
uniprot id: F6QKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:HSPH1
gene id: 9544:HSPH1
uniprot id: H9FP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9544:SV2C
gene id: 9544:SV2C
uniprot id: A0A8J8YE61
uniprot id: F7GQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9544:MARCH4
gene id: 9544:MARCH4
uniprot id: A0A8J8YPJ0
uniprot id: F7HSL8
names: Subcellular Location Annotation
messages: Membrane

9544:RBBP4
gene id: 9544:RBBP4
uniprot id: H9ZBY4
names: Subcellular Location Annotation
messages: Nucleus

9544:GTPBP8
gene id: 9544:GTPBP8
uniprot id: F6TXK5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9544:VTI1B
gene id: 9544:VTI1B
uniprot id: A0A5F8A9L6
uniprot id: A0A8J8XGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9544:RPA2
gene id: 9544:RPA2
uniprot id: I0FU12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9544:HCRTR1
gene id: 9544:HCRTR1
uniprot id: A0A8J8YNB9
uniprot id: F7FE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:FOLR2
gene id: 9544:FOLR2
uniprot id: A0A8J8XNQ3
uniprot id: F7CR90
uniprot id: H9Z0D2
names: Similarity
messages: Belongs to the folate receptor family.

9544:BRIX1
gene id: 9544:BRIX1
uniprot id: A0A1D5RA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9544:TCN1
gene id: 9544:TCN1
uniprot id: A0A8J8Y8G8
uniprot id: F6Z770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9544:PI4KB
gene id: 9544:PI4KB
uniprot id: A0A1D5RJT7
uniprot id: F6XXX9
uniprot id: I0FSN3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:POLR2J
gene id: 9544:POLR2J
uniprot id: H9EMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9544:NEUROD2
gene id: 9544:NEUROD2
uniprot id: F7CUL4
names: Subcellular Location Annotation
messages: Nucleus

9544:SEMA5A
gene id: 9544:SEMA5A
uniprot id: I2CT92
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MAPRE3
gene id: 9544:MAPRE3
uniprot id: A0A5F7ZS41
uniprot id: A0A8J8YS23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9544:C2
gene id: 9544:C2
uniprot id: A0A8J8XKY4
uniprot id: F6YK65
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:TRAF1
gene id: 9544:TRAF1
uniprot id: A0A8J8XAG6
uniprot id: F7GHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:PPP1R2C
gene id: 9544:PPP1R2C
uniprot id: A0A8J8Y8K7
uniprot id: F7GFL6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9544:WASHC5
gene id: 9544:WASHC5
uniprot id: H9G2L5
names: Similarity
messages: Belongs to the strumpellin family.

9544:GJA4
gene id: 9544:GJA4
uniprot id: A0A654IC41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:MBLAC1
gene id: 9544:MBLAC1
uniprot id: A0A8J8YHQ0
uniprot id: G7MNT5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9544:EIF4E3
gene id: 9544:EIF4E3
uniprot id: H9EPE4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9544:STAR
gene id: 9544:STAR
uniprot id: I2CUU5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9544:KEG06 p11
gene id: 9544:KEG06_p11
uniprot id: I3W8K0
uniprot id: Q6IYH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SLC1A6
gene id: 9544:SLC1A6
uniprot id: A0A5F7ZGG4
uniprot id: A0A8J8YK82
uniprot id: G7NM13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GNA14
gene id: 9544:GNA14
uniprot id: A0A8J8YFF7
uniprot id: F7AQR3
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9544:MAL2
gene id: 9544:MAL2
uniprot id: A0A5K1TZG0
names: Subcellular Location Annotation
messages: Membrane

9544:RBBP8
gene id: 9544:RBBP8
uniprot id: H9ZBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9544:LOC700446
gene id: 9544:LOC700446
uniprot id: H9H307
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:TRIM63
gene id: 9544:TRIM63
uniprot id: F6X0F9
names: Subcellular Location Annotation
messages: Nucleus

9544:HADHB
gene id: 9544:HADHB
uniprot id: A0A1D5RGU1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9544:TMEM208
gene id: 9544:TMEM208
uniprot id: F6UJ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9544:LOC698693
gene id: 9544:LOC698693
uniprot id: G7N3T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:DNAL4
gene id: 9544:DNAL4
uniprot id: A0A8J8XBG2
uniprot id: F7AP66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9544:ATP1A2
gene id: 9544:ATP1A2
uniprot id: A0A1D5R1L9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CARMIL3
gene id: 9544:CARMIL3
uniprot id: F7E9C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9544:ARHGDIB
gene id: 9544:ARHGDIB
uniprot id: A0A8J8XQ13
uniprot id: G7N6F2
names: Similarity
messages: Belongs to the Rho GDI family.

9544:BHMT2
gene id: 9544:BHMT2
uniprot id: A0A1D5QR99
uniprot id: A0A8J8Y700
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9544:PSMD7
gene id: 9544:PSMD7
uniprot id: F6TS39
names: Similarity
messages: Belongs to the peptidase M67A family.

9544:CELF2
gene id: 9544:CELF2
uniprot id: A0A1D5QPJ8
uniprot id: H9FNW3
uniprot id: H9FNW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9544:USP5
gene id: 9544:USP5
uniprot id: A0A8J8XRW9
uniprot id: F7CT78
uniprot id: G7N5U1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:HIST2H2AC
gene id: 9544:HIST2H2AC
uniprot id: A0A8J8XTY8
uniprot id: F7BRD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ATF1
gene id: 9544:ATF1
uniprot id: A0A8J8XY03
uniprot id: F7HB38
names: Subcellular Location Annotation
messages: Nucleus

9544:PLCB1
gene id: 9544:PLCB1
uniprot id: F6R8R8
uniprot id: F6ZKL2
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9544:RAN
gene id: 9544:RAN
uniprot id: A0A1D5Q7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9544:MED27
gene id: 9544:MED27
uniprot id: A0A8J8XJN5
uniprot id: F7GN97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:PSMD13
gene id: 9544:PSMD13
uniprot id: H9FXJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9544:CCL19
gene id: 9544:CCL19
uniprot id: Q8HYP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:NELFE
gene id: 9544:NELFE
uniprot id: G7MRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9544:LOC693464
gene id: 9544:LOC693464
uniprot id: A0A8J8Y6A8
uniprot id: F7FJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:ATP6AP1
gene id: 9544:ATP6AP1
uniprot id: I2CYP6
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9544:LHX1
gene id: 9544:LHX1
uniprot id: A0A8J8XTP5
uniprot id: F7F4Z5
names: Subcellular Location Annotation
messages: Nucleus

9544:EDNRA
gene id: 9544:EDNRA
uniprot id: A0A8J8YLD3
uniprot id: I0FJM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9544:CDKN3
gene id: 9544:CDKN3
uniprot id: F7FIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9544:CHL1
gene id: 9544:CHL1
uniprot id: H9FNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9544:BMP7
gene id: 9544:BMP7
uniprot id: A0A8J8XHT8
uniprot id: F6ZJT0
names: Similarity
messages: Belongs to the TGF-beta family.

9544:MGAT4A
gene id: 9544:MGAT4A
uniprot id: A0A8J8XA59
uniprot id: F6W7B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SLC16A8
gene id: 9544:SLC16A8
uniprot id: A0A5F7ZDC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9544:ADRB2
gene id: 9544:ADRB2
uniprot id: G7MVF9
uniprot id: Q28509
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Membrane
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9544:KCNJ8
gene id: 9544:KCNJ8
uniprot id: F7H7S9
uniprot id: Q0GF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:CAPN9
gene id: 9544:CAPN9
uniprot id: F6TLE9
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:TAS1R2
gene id: 9544:TAS1R2
uniprot id: A3QP01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms heterodimers with TAS1R3.
messages: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).

9544:RAB9B
gene id: 9544:RAB9B
uniprot id: A0A8J8YG04
uniprot id: F6WKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9544:NHP2
gene id: 9544:NHP2
uniprot id: A0A8J8Y5Y9
uniprot id: I0FLZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9544:LOC702514
gene id: 9544:LOC702514
uniprot id: F6TJQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:GJB6
gene id: 9544:GJB6
uniprot id: A0A8J8XYN2
uniprot id: G7NJQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:EPHA2
gene id: 9544:EPHA2
uniprot id: Q1HKZ4
names: Subcellular Location Annotation
messages: Membrane

9544:SLC7A2
gene id: 9544:SLC7A2
uniprot id: A0A5F8A3A8
uniprot id: F6XEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9544:FUT1
gene id: 9544:FUT1
uniprot id: A0A8J8Y607
uniprot id: Q9TUD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9544:ERRFI1
gene id: 9544:ERRFI1
uniprot id: A0A8J8Y452
uniprot id: F6SQ62
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9544:PAX5
gene id: 9544:PAX5
uniprot id: A0A8J8XLV0
uniprot id: G7NF13
names: Subcellular Location Annotation
messages: Nucleus

9544:ACY3
gene id: 9544:ACY3
uniprot id: A0A8J8Y922
uniprot id: F7A210
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9544:CARTPT
gene id: 9544:CARTPT
uniprot id: A0A8J8XAQ1
uniprot id: F6WIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9544:FHL5
gene id: 9544:FHL5
uniprot id: A0A8J8XJ17
uniprot id: F7F0V6
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9544:PTS
gene id: 9544:PTS
uniprot id: I2CVZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9544:PNP
gene id: 9544:PNP
uniprot id: H9EX88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9544:RPL4
gene id: 9544:RPL4
uniprot id: A0A5F7Z9N3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9544:SMN1
gene id: 9544:SMN1
uniprot id: F6V985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

9544:PEX3
gene id: 9544:PEX3
uniprot id: A0A8J8Y698
uniprot id: G7MQ77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9544:PRKAR1A
gene id: 9544:PRKAR1A
uniprot id: F6WM87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9544:PRNP
gene id: 9544:PRNP
uniprot id: A0A8J8YKW8
uniprot id: G7N2W1
uniprot id: P67997
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9544:LYRM4
gene id: 9544:LYRM4
uniprot id: H9FMX8
names: Similarity
messages: Belongs to the complex I LYR family.

9544:PIGG
gene id: 9544:PIGG
uniprot id: F7HKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:NACC2
gene id: 9544:NACC2
uniprot id: F6X1Q6
names: Subcellular Location Annotation
messages: Nucleus

9544:S1PR4
gene id: 9544:S1PR4
uniprot id: A0A8J8XRX6
uniprot id: F7HQU7
names: Subcellular Location Annotation
messages: Membrane

9544:DGKG
gene id: 9544:DGKG
uniprot id: F6RTS2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:FAM216B
gene id: 9544:FAM216B
uniprot id: F6TNU8
names: Similarity
messages: Belongs to the FAM216 family.

9544:DKK4
gene id: 9544:DKK4
uniprot id: A0A8J8XXB0
uniprot id: F7H9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9544:WTAP
gene id: 9544:WTAP
uniprot id: H9Z1B4
names: Similarity
messages: Belongs to the fl(2)d family.

9544:EMC10
gene id: 9544:EMC10
uniprot id: A0A5K1TXN9
uniprot id: H9EV47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9544:CORO2B
gene id: 9544:CORO2B
uniprot id: F7HBV6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:PDGFRA
gene id: 9544:PDGFRA
uniprot id: A0A8J8YH90
uniprot id: G7MTB0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9544:RARS2
gene id: 9544:RARS2
uniprot id: F7HQQ3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:CSTF1
gene id: 9544:CSTF1
uniprot id: A0A8J8XWL5
uniprot id: G7N4H3
names: Subcellular Location Annotation
messages: Nucleus

9544:OTX2
gene id: 9544:OTX2
uniprot id: A0A1D5QAZ9
uniprot id: G7MXZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9544:C11H12orf10
gene id: 9544:C11H12orf10
uniprot id: G7N745
names: Similarity
messages: Belongs to the MYG1 family.

9544:APOC2
gene id: 9544:APOC2
uniprot id: A0A8J8XRV4
uniprot id: G7NMB2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9544:NDUFB4
gene id: 9544:NDUFB4
uniprot id: F7GV51
uniprot id: G7MKF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:DIP2A
gene id: 9544:DIP2A
uniprot id: A0A1D5QSZ1
names: Similarity
messages: Belongs to the DIP2 family.

9544:ELF2
gene id: 9544:ELF2
uniprot id: A0A1D5QNV7
uniprot id: A0A5K1VB63
uniprot id: H9YX03
uniprot id: H9Z648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:CST3
gene id: 9544:CST3
uniprot id: O19092
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
messages: Belongs to the cystatin family.
messages: Secreted

9544:LCA5
gene id: 9544:LCA5
uniprot id: A0A8J8XRT6
uniprot id: G7MPS6
names: Similarity
messages: Belongs to the LCA5 family.

9544:SMPD2
gene id: 9544:SMPD2
uniprot id: A0A8J8YKE9
uniprot id: F7EAJ0
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9544:MDH1B
gene id: 9544:MDH1B
uniprot id: F7AU42
uniprot id: G7N8R4
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9544:GDI1
gene id: 9544:GDI1
uniprot id: F7FLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9544:BMP4
gene id: 9544:BMP4
uniprot id: A0A8J8Y0E3
uniprot id: F7ACJ7
names: Similarity
messages: Belongs to the TGF-beta family.

9544:LEPROTL1
gene id: 9544:LEPROTL1
uniprot id: H9EQQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9544:LOC697706
gene id: 9544:LOC697706
uniprot id: A0A5F8AGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ARMC8
gene id: 9544:ARMC8
uniprot id: A0A1D5Q324
uniprot id: A0A1D5QZ15
uniprot id: A0A5F7ZJD1
uniprot id: H9EN37
uniprot id: H9EN38
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:USP1
gene id: 9544:USP1
uniprot id: A0A8J8Y508
uniprot id: G7MHB3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:RCAN1
gene id: 9544:RCAN1
uniprot id: F6Q8Z0
names: Similarity
messages: Belongs to the RCAN family.

9544:CNOT8
gene id: 9544:CNOT8
uniprot id: A0A1D5R1V6
uniprot id: A0A8J8XE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9544:CSTA
gene id: 9544:CSTA
uniprot id: A0A8J8XQZ7
uniprot id: F7H310
names: Similarity
messages: Belongs to the cystatin family.

9544:MFGE8
gene id: 9544:MFGE8
uniprot id: A0A8J8Y1U3
uniprot id: G7MYS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ATP5PD
gene id: 9544:ATP5PD
uniprot id: F6PTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9544:MAPKAP1
gene id: 9544:MAPKAP1
uniprot id: A0A8J8XU29
uniprot id: F6U0S1
uniprot id: G7NEQ6
uniprot id: H9FZP7
names: Similarity
messages: Belongs to the SIN1 family.

9544:LGI3
gene id: 9544:LGI3
uniprot id: F7HAC9
names: Subcellular Location Annotation
messages: Secreted

9544:MLST8
gene id: 9544:MLST8
uniprot id: H9FYD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9544:MLEC
gene id: 9544:MLEC
uniprot id: A0A8J8YPL6
uniprot id: I0FWR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ADAMTS15
gene id: 9544:ADAMTS15
uniprot id: F7FFL7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:TMEM176B
gene id: 9544:TMEM176B
uniprot id: H9FTD1
uniprot id: H9FTD2
names: Similarity
messages: Belongs to the TMEM176 family.

9544:INSIG1
gene id: 9544:INSIG1
uniprot id: H9EVZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9544:ZER1
gene id: 9544:ZER1
uniprot id: A0A8J8YMV6
uniprot id: G7NFR5
uniprot id: H9FNQ4
names: Similarity
messages: Belongs to the zyg-11 family.

9544:GTDC1
gene id: 9544:GTDC1
uniprot id: H9EX90
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9544:SLC39A12
gene id: 9544:SLC39A12
uniprot id: A0A8J8XTT3
uniprot id: F6PK09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9544:SLC11A2
gene id: 9544:SLC11A2
uniprot id: F7HDZ6
uniprot id: H9Z9D3
names: Similarity
messages: Belongs to the NRAMP family.

9544:TRAF5
gene id: 9544:TRAF5
uniprot id: A0A5F8AI01
uniprot id: F7FNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:ERCC1
gene id: 9544:ERCC1
uniprot id: A0A1D5Q468
uniprot id: F6YL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9544:MCRIP2
gene id: 9544:MCRIP2
uniprot id: F6Z225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9544:HOXB6
gene id: 9544:HOXB6
uniprot id: A0A8J8XLG6
uniprot id: F7HN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:MTERF3
gene id: 9544:MTERF3
uniprot id: G7MZT4
names: Similarity
messages: Belongs to the mTERF family.

9544:KDSR
gene id: 9544:KDSR
uniprot id: F7HPT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:GATAD1
gene id: 9544:GATAD1
uniprot id: I0FTS7
names: Subcellular Location Annotation
messages: Nucleus

9544:FAM167A
gene id: 9544:FAM167A
uniprot id: A0A1D5Q4C6
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9544:NIT2
gene id: 9544:NIT2
uniprot id: I0FTK4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9544:GRM3
gene id: 9544:GRM3
uniprot id: A0A8J8Y9X5
uniprot id: F6YNZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9544:MAP2K4
gene id: 9544:MAP2K4
uniprot id: A0A1D5QAU9
uniprot id: F7FU91
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CCNA2
gene id: 9544:CCNA2
uniprot id: A0A8J8XEW4
uniprot id: F6WZV1
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9544:GNAT3
gene id: 9544:GNAT3
uniprot id: A0A5F8ALC3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:ATP2B4
gene id: 9544:ATP2B4
uniprot id: A0A5F8ABU2
uniprot id: A0A5K1UV41
uniprot id: F7HU67
uniprot id: Q5BN38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:COX4I1
gene id: 9544:COX4I1
uniprot id: F7HCZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9544:ARL6
gene id: 9544:ARL6
uniprot id: A0A5F7ZYN6
uniprot id: F7EGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9544:CPLX1
gene id: 9544:CPLX1
uniprot id: A0A8J8YSU7
uniprot id: H9FP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9544:TPM2
gene id: 9544:TPM2
uniprot id: F7GSX6
uniprot id: H9FZ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:SEMA6A
gene id: 9544:SEMA6A
uniprot id: F6UYV1
uniprot id: F7CJ41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MEF2A
gene id: 9544:MEF2A
uniprot id: F7FGB3
uniprot id: H9FUJ3
uniprot id: H9FUJ5
uniprot id: H9FUJ6
names: Subcellular Location Annotation
messages: Nucleus

9544:S100A4
gene id: 9544:S100A4
uniprot id: A0A8J8YC96
uniprot id: F7GDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:CMTM2
gene id: 9544:CMTM2
uniprot id: A0A8J8XXK9
uniprot id: F6RFF0
names: Subcellular Location Annotation
messages: Membrane

9544:FAM162A
gene id: 9544:FAM162A
uniprot id: H9FSV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9544:SDHAF4
gene id: 9544:SDHAF4
uniprot id: A0A8J8YA11
uniprot id: F7F317
names: Similarity
messages: Belongs to the SDHAF4 family.

9544:SND1
gene id: 9544:SND1
uniprot id: A0A8J8YGX9
uniprot id: G7MMA3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9544:TFIP11
gene id: 9544:TFIP11
uniprot id: A0A8J8XHV1
uniprot id: A1XD94
uniprot id: G7N3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9544:ATL2
gene id: 9544:ATL2
uniprot id: F6TI01
uniprot id: F6YCC3
uniprot id: H9FYE2
uniprot id: H9YZA6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9544:SORCS1
gene id: 9544:SORCS1
uniprot id: F7A6D9
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9544:C1H1orf74
gene id: 9544:C1H1orf74
uniprot id: A0A5F8AJB2
names: Similarity
messages: Belongs to the UPF0739 family.

9544:FMC1
gene id: 9544:FMC1
uniprot id: A0A8J8XK66
uniprot id: F7H3V6
names: Similarity
messages: Belongs to the FMC1 family.

9544:HIST1H1T
gene id: 9544:HIST1H1T
uniprot id: G7MR24
uniprot id: P40286
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
messages: Nucleus
messages: Phosphorylated in early spermatids.
messages: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.

9544:SURF6
gene id: 9544:SURF6
uniprot id: G7NFG2
names: Similarity
messages: Belongs to the SURF6 family.

9544:DYNLRB2
gene id: 9544:DYNLRB2
uniprot id: F7FWX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9544:IGFBP5
gene id: 9544:IGFBP5
uniprot id: A0A8J8YJ63
uniprot id: F6YKJ0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:SHCBP1
gene id: 9544:SHCBP1
uniprot id: A0A5F7Z8A7
names: Subcellular Location Annotation
messages: spindle

9544:ARL3
gene id: 9544:ARL3
uniprot id: H9FUD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9544:LOC100423381
gene id: 9544:LOC100423381
uniprot id: A0A5F8ALR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:MRE11
gene id: 9544:MRE11
uniprot id: A0A5K1UX03
uniprot id: H9Z952
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9544:CCR7
gene id: 9544:CCR7
uniprot id: Q8HZR6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:RPS10
gene id: 9544:RPS10
uniprot id: F6TQP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9544:EIF3D
gene id: 9544:EIF3D
uniprot id: A0A1D5Q459
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9544:GAD2
gene id: 9544:GAD2
uniprot id: A0A8J8XZF1
uniprot id: G7N1R9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:MTM1
gene id: 9544:MTM1
uniprot id: F6Z4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9544:ASPH
gene id: 9544:ASPH
uniprot id: F6TBU7
uniprot id: H9EXU6
uniprot id: H9Z957
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:DGKB
gene id: 9544:DGKB
uniprot id: A0A5F8A472
uniprot id: H9FQL5
uniprot id: H9FQL9
uniprot id: I2CTX4
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:ASB2
gene id: 9544:ASB2
uniprot id: F7EA98
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:BMP5
gene id: 9544:BMP5
uniprot id: F7H4M7
names: Similarity
messages: Belongs to the TGF-beta family.

9544:NDUFB6
gene id: 9544:NDUFB6
uniprot id: A0A1D5QZD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:PCMTD1
gene id: 9544:PCMTD1
uniprot id: A0A8J8XTC9
uniprot id: F7EGP9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9544:MTFR1
gene id: 9544:MTFR1
uniprot id: A0A1D5Q8K2
uniprot id: F6WPS9
uniprot id: G7MZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9544:GRID2
gene id: 9544:GRID2
uniprot id: F7BZZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:KYNU
gene id: 9544:KYNU
uniprot id: F6URB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GPAT3
gene id: 9544:GPAT3
uniprot id: A0A1D5RC36
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:CCR8
gene id: 9544:CCR8
uniprot id: A0A8J8XDM8
uniprot id: F6U6G8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:UPF3B
gene id: 9544:UPF3B
uniprot id: F6V224
uniprot id: F6V236
names: Similarity
messages: Belongs to the RENT3 family.

9544:OGDHL
gene id: 9544:OGDHL
uniprot id: I2CYQ6
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9544:GDF9
gene id: 9544:GDF9
uniprot id: H9FSW7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9544:AVL9
gene id: 9544:AVL9
uniprot id: H9FRN4
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9544:ZNF622
gene id: 9544:ZNF622
uniprot id: A0A8J8YSR4
uniprot id: F7D6E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9544:GABRA5
gene id: 9544:GABRA5
uniprot id: A0A8J8Y7H1
uniprot id: G7MW76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:RASSF1
gene id: 9544:RASSF1
uniprot id: H9Z4T9
names: Subcellular Location Annotation
messages: cytoskeleton

9544:GJB2
gene id: 9544:GJB2
uniprot id: G7NJQ7
uniprot id: Q8MIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB4. Interacts with CNST (By similarity).
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
messages: gap junction

9544:PARP12
gene id: 9544:PARP12
uniprot id: H9ZCG0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:DIO2
gene id: 9544:DIO2
uniprot id: H9FN65
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9544:CXCR6
gene id: 9544:CXCR6
uniprot id: F7BTV1
uniprot id: H9Z4H8
uniprot id: Q9XT45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9544:PPAT
gene id: 9544:PPAT
uniprot id: A0A8J8YQ80
uniprot id: F7GPV9
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9544:UBE2F
gene id: 9544:UBE2F
uniprot id: F6X242
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:CRP
gene id: 9544:CRP
uniprot id: G7ME52
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:ST18
gene id: 9544:ST18
uniprot id: H9G2C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9544:ADH1B
gene id: 9544:ADH1B
uniprot id: H9Z213
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9544:MYCBP2
gene id: 9544:MYCBP2
uniprot id: F7E6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-Cys relay (RCR) family.
messages: axon

9544:LOC702046
gene id: 9544:LOC702046
uniprot id: A0A5F7Z8K8
uniprot id: F6WMH1
names: Similarity
messages: Belongs to the serpin family.

9544:NEMF
gene id: 9544:NEMF
uniprot id: A0A5F8AQ40
names: Similarity
messages: Belongs to the NEMF family.

9544:AP3S2
gene id: 9544:AP3S2
uniprot id: A0A8J8XNK2
uniprot id: G7MVX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9544:FGF1
gene id: 9544:FGF1
uniprot id: A0A8J8YR51
uniprot id: F7E243
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9544:ENTPD7
gene id: 9544:ENTPD7
uniprot id: F7HAL5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:KCNS1
gene id: 9544:KCNS1
uniprot id: A4K2T1
uniprot id: G1K376
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

9544:PFN4
gene id: 9544:PFN4
uniprot id: A0A8J8Y8Z1
uniprot id: F6XA76
names: Similarity
messages: Belongs to the profilin family.

9544:ADAMTS10
gene id: 9544:ADAMTS10
uniprot id: F7C9E9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:SERPINA3
gene id: 9544:SERPINA3
uniprot id: A0A5K1UMZ5
uniprot id: F6SL79
names: Similarity
messages: Belongs to the serpin family.

9544:ST3GAL4
gene id: 9544:ST3GAL4
uniprot id: F7EUG5
uniprot id: H9FYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:ROGDI
gene id: 9544:ROGDI
uniprot id: F7EM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Perikaryon
messages: Presynapse
messages: synaptic vesicle

9544:TRIM2
gene id: 9544:TRIM2
uniprot id: A0A1D5QWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9544:ATP6V0B
gene id: 9544:ATP6V0B
uniprot id: H9ZA59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9544:NHEJ1
gene id: 9544:NHEJ1
uniprot id: E5FGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9544:POGLUT2
gene id: 9544:POGLUT2
uniprot id: H9FZN8
names: Similarity
messages: Belongs to the KDELC family.

9544:ATG7
gene id: 9544:ATG7
uniprot id: A0A8J8YRG3
uniprot id: G7MKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9544:TMED9
gene id: 9544:TMED9
uniprot id: F6WAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PGK1
gene id: 9544:PGK1
uniprot id: I0FSL5
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9544:IPO9
gene id: 9544:IPO9
uniprot id: H9ZB37
names: Subcellular Location Annotation
messages: Cytoplasm

9544:CCNE2
gene id: 9544:CCNE2
uniprot id: F6Q7B1
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9544:NDUFA11
gene id: 9544:NDUFA11
uniprot id: H9EXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:COQ5
gene id: 9544:COQ5
uniprot id: H9EWI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9544:RPS18
gene id: 9544:RPS18
uniprot id: A0A8J8YPT9
uniprot id: G7N7R0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9544:ZNRF4
gene id: 9544:ZNRF4
uniprot id: F7DGP6
names: Subcellular Location Annotation
messages: Membrane

9544:COPZ2
gene id: 9544:COPZ2
uniprot id: F6T427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9544:GLRB
gene id: 9544:GLRB
uniprot id: H9Z7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9544:ARX
gene id: 9544:ARX
uniprot id: A0A5F8ABV8
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC34A1
gene id: 9544:SLC34A1
uniprot id: A0A1D5R1A3
uniprot id: A0A8J8YML6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9544:RTCB
gene id: 9544:RTCB
uniprot id: A0A8J8Y1J0
uniprot id: F7HFI7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9544:IFNB1
gene id: 9544:IFNB1
uniprot id: B6CK14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:STAG1
gene id: 9544:STAG1
uniprot id: H9EMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9544:ARAF
gene id: 9544:ARAF
uniprot id: H9FU32
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9544:SLC16A7
gene id: 9544:SLC16A7
uniprot id: F7HT13
uniprot id: G8F1E6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9544:DSTN
gene id: 9544:DSTN
uniprot id: H9EM17
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9544:GSC2
gene id: 9544:GSC2
uniprot id: F7HKV0
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC25A53
gene id: 9544:SLC25A53
uniprot id: A0A1D5QCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:OVOL1
gene id: 9544:OVOL1
uniprot id: F7FEA8
names: Subcellular Location Annotation
messages: Nucleus

9544:MAP3K13
gene id: 9544:MAP3K13
uniprot id: A0A1D5R7X4
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9544:PHOSPHO2
gene id: 9544:PHOSPHO2
uniprot id: A0A8J8XNS4
uniprot id: F7GM50
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9544:PPP1R12B
gene id: 9544:PPP1R12B
uniprot id: H9EUQ6
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9544:TBL1Y
gene id: 9544:TBL1Y
uniprot id: A0A1D5QQ61
uniprot id: B8YE10
names: Similarity
messages: Belongs to the WD repeat EBI family.

9544:SUPV3L1
gene id: 9544:SUPV3L1
uniprot id: I0FUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9544:SAP18
gene id: 9544:SAP18
uniprot id: F7CXR4
names: Similarity
messages: Belongs to the SAP18 family.

9544:PTPRA
gene id: 9544:PTPRA
uniprot id: F6TLA3
uniprot id: H9ZBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9544:UPP1
gene id: 9544:UPP1
uniprot id: A0A8J8Y8S2
uniprot id: F7F1M1
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9544:RBP1
gene id: 9544:RBP1
uniprot id: F7A9X9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:WDR55
gene id: 9544:WDR55
uniprot id: A0A8J8YP50
uniprot id: H9Z3T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9544:SOX10
gene id: 9544:SOX10
uniprot id: A0A5F7ZM79
names: Subcellular Location Annotation
messages: Nucleus

9544:TYW3
gene id: 9544:TYW3
uniprot id: H9FPV5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9544:ZDHHC1
gene id: 9544:ZDHHC1
uniprot id: F6WYM4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:GGA1
gene id: 9544:GGA1
uniprot id: H9FSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9544:MRPL13
gene id: 9544:MRPL13
uniprot id: A0A8J8YP67
uniprot id: F7HQC8
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9544:LOC715580
gene id: 9544:LOC715580
uniprot id: A0A8J8XKR0
uniprot id: G7MH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9544:APOA2
gene id: 9544:APOA2
uniprot id: A0A8J8XNR3
uniprot id: F6SD23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9544:ABCD3
gene id: 9544:ABCD3
uniprot id: A0A5F7ZJ08
uniprot id: H9ESW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9544:ITGB3
gene id: 9544:ITGB3
uniprot id: G7NJ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9544:CAMK1
gene id: 9544:CAMK1
uniprot id: A0A8J8YFE0
uniprot id: I0FVW2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:LOC722148
gene id: 9544:LOC722148
uniprot id: H9EXP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TCTEX1D2
gene id: 9544:TCTEX1D2
uniprot id: H9FSG5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9544:PDCL3
gene id: 9544:PDCL3
uniprot id: H9EX97
names: Similarity
messages: Belongs to the phosducin family.

9544:IP6K2
gene id: 9544:IP6K2
uniprot id: H9FVJ0
uniprot id: I2CT80
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9544:PANX3
gene id: 9544:PANX3
uniprot id: A0A8J8YEY7
uniprot id: F6THN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9544:WRNIP1
gene id: 9544:WRNIP1
uniprot id: H9FXB7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9544:ATP6V1G2
gene id: 9544:ATP6V1G2
uniprot id: A0A8J8YHC1
uniprot id: G7MRI0
uniprot id: Q5TM18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Melanosome
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.
messages: clathrin-coated vesicle membrane

9544:TMEM182
gene id: 9544:TMEM182
uniprot id: A0A1D5QYS0
uniprot id: A0A5F7ZWR7
uniprot id: A0A8J8Y9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9544:MIOS
gene id: 9544:MIOS
uniprot id: A0A8J8YEA4
uniprot id: H9EQA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9544:IRAK2
gene id: 9544:IRAK2
uniprot id: G7MKR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9544:ISL1
gene id: 9544:ISL1
uniprot id: A0A8J8XGP4
uniprot id: F6XYB8
names: Subcellular Location Annotation
messages: Nucleus

9544:MRPL24
gene id: 9544:MRPL24
uniprot id: A0A8J8YI65
uniprot id: F7HPI2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9544:PLCG1
gene id: 9544:PLCG1
uniprot id: A0A1D5R8E9
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9544:LOC100430845
gene id: 9544:LOC100430845
uniprot id: G7MWD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CCL17
gene id: 9544:CCL17
uniprot id: A0A8J8Y548
uniprot id: F7E988
uniprot id: Q8HYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity).
messages: Secreted

9544:AKIRIN2
gene id: 9544:AKIRIN2
uniprot id: H9EMR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9544:TRAF4
gene id: 9544:TRAF4
uniprot id: H9ET39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:PDE6C
gene id: 9544:PDE6C
uniprot id: A0A8J8XAW8
uniprot id: F7GEY4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:KDELR2
gene id: 9544:KDELR2
uniprot id: I0FKJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:INSIG2
gene id: 9544:INSIG2
uniprot id: F7HBW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9544:DYM
gene id: 9544:DYM
uniprot id: F7CL08
names: Similarity
messages: Belongs to the dymeclin family.

9544:VCAN
gene id: 9544:VCAN
uniprot id: A0A5F7ZQ13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:CASC4
gene id: 9544:CASC4
uniprot id: H9FPH5
uniprot id: H9FPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9544:ASB1
gene id: 9544:ASB1
uniprot id: A0A5F7ZH66
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:LOC704989
gene id: 9544:LOC704989
uniprot id: A0A5F8AQ96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:ZBTB8OS
gene id: 9544:ZBTB8OS
uniprot id: F7GQ99
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9544:UXT
gene id: 9544:UXT
uniprot id: G7NR60
names: Similarity
messages: Belongs to the UXT family.

9544:LUC7L3
gene id: 9544:LUC7L3
uniprot id: A0A5F7ZXL8
uniprot id: A0A8J8XRC0
uniprot id: F7H6R2
uniprot id: H9ZA17
names: Similarity
messages: Belongs to the Luc7 family.

9544:ELAC1
gene id: 9544:ELAC1
uniprot id: A0A8J8Y9Z5
uniprot id: G7NKQ7
names: Subunit
messages: Homodimer.

9544:OR14J1
gene id: 9544:OR14J1
uniprot id: F6SN86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:STOML2
gene id: 9544:STOML2
uniprot id: A0A8J8YD82
uniprot id: G7NFE6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9544:PSMG1
gene id: 9544:PSMG1
uniprot id: A0A8J8XIG5
uniprot id: G7MMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9544:CRYAB
gene id: 9544:CRYAB
uniprot id: A0A8J8XXS5
uniprot id: F7H3G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9544:GPR152
gene id: 9544:GPR152
uniprot id: F7FZ44
names: Subcellular Location Annotation
messages: Cell membrane

9544:LOC715257
gene id: 9544:LOC715257
uniprot id: H9ZBL7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:TPM4
gene id: 9544:TPM4
uniprot id: A0A5F8AC84
uniprot id: H9END9
uniprot id: I0FUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:AATF
gene id: 9544:AATF
uniprot id: H9FSW5
names: Similarity
messages: Belongs to the AATF family.

9544:DEFA4
gene id: 9544:DEFA4
uniprot id: Q5I2P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9544:POU5F1
gene id: 9544:POU5F1
uniprot id: Q5TM49
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Cytoplasm
messages: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
messages: Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10. Interacts with PCGF1. Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent. Interacts with ZNF322. Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355. Interacts (when phosphorylated on Ser-355) with FBXW8. Interacts with FBXW4. Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity). Interacts with DDX56 (By similarity).
messages: Nucleus
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The POU-specific domain mediates interaction with PKM.
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.

9544:AP1M2
gene id: 9544:AP1M2
uniprot id: G7NL08
uniprot id: H9H4V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9544:TFPI
gene id: 9544:TFPI
uniprot id: I0FUM5
uniprot id: Q28864
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
messages: O-glycosylated.
messages: Secreted
messages: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).

9544:PAQR3
gene id: 9544:PAQR3
uniprot id: F7GGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:PYCR3
gene id: 9544:PYCR3
uniprot id: A0A5F8AP82
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:TFDP3
gene id: 9544:TFDP3
uniprot id: A0A8J8XSQ2
uniprot id: F7HDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:OR6X1
gene id: 9544:OR6X1
uniprot id: A0A8J8Y9J1
uniprot id: F7F452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PDLIM1
gene id: 9544:PDLIM1
uniprot id: F6YRD0
names: Subcellular Location Annotation
messages: Z line

9544:CXCR4
gene id: 9544:CXCR4
uniprot id: H9ZDD5
uniprot id: P79394
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
messages: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
messages: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.
messages: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.

9544:LCN9
gene id: 9544:LCN9
uniprot id: D1YSI6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:NMD3
gene id: 9544:NMD3
uniprot id: A0A5F8A171
uniprot id: H9ER14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9544:GOLPH3
gene id: 9544:GOLPH3
uniprot id: H9EPH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9544:ESX1
gene id: 9544:ESX1
uniprot id: A0A8J8XGV9
uniprot id: F7FB23
names: Subcellular Location Annotation
messages: Nucleus

9544:TXNL4B
gene id: 9544:TXNL4B
uniprot id: A0A8J8YJ01
uniprot id: F6Z0Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9544:SPOCK3
gene id: 9544:SPOCK3
uniprot id: A0A5K1U5H8
uniprot id: F7FCP3
uniprot id: H9FV41
uniprot id: I2CYA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KCNH1
gene id: 9544:KCNH1
uniprot id: A0A5K1UTZ2
uniprot id: A0A8J8Y8B7
uniprot id: G7MEN1
names: Subcellular Location Annotation
messages: Membrane

9544:PPP3R1
gene id: 9544:PPP3R1
uniprot id: H9EN69
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9544:MDM2
gene id: 9544:MDM2
uniprot id: A0A8J8YAF0
uniprot id: G7N7L5
uniprot id: H9FUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9544:PRF1
gene id: 9544:PRF1
uniprot id: A0A5F7ZYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9544:SRD5A1
gene id: 9544:SRD5A1
uniprot id: F6XQ47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

9544:EVA1A
gene id: 9544:EVA1A
uniprot id: A0A8J8YR48
uniprot id: F6Y876
names: Similarity
messages: Belongs to the EVA1 family.

9544:PPP2R2C
gene id: 9544:PPP2R2C
uniprot id: F6Z2Q9
uniprot id: H9EMD0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:GNPDA2
gene id: 9544:GNPDA2
uniprot id: A0A1D5Q159
uniprot id: A0A8J8YRF0
uniprot id: H9ENJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9544:PROC
gene id: 9544:PROC
uniprot id: A0A1D5QSH6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:S1PR3
gene id: 9544:S1PR3
uniprot id: A0A8J8Y812
uniprot id: G7NEM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9544:AP5M1
gene id: 9544:AP5M1
uniprot id: F7HK39
uniprot id: F7HM76
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9544:OPA3
gene id: 9544:OPA3
uniprot id: I2CXP2
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9544:HOXC12
gene id: 9544:HOXC12
uniprot id: F6S5W5
names: Subcellular Location Annotation
messages: Nucleus

9544:INSL5
gene id: 9544:INSL5
uniprot id: A0A8J8XX27
uniprot id: F6XT44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:SCD5
gene id: 9544:SCD5
uniprot id: F6TFW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9544:CFAP45
gene id: 9544:CFAP45
uniprot id: A0A1D5R535
uniprot id: F6U1H6
names: Similarity
messages: Belongs to the CFAP45 family.

9544:AP4S1
gene id: 9544:AP4S1
uniprot id: H9FPB4
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9544:NAB1
gene id: 9544:NAB1
uniprot id: F7GU92
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9544:NDUFAF7
gene id: 9544:NDUFAF7
uniprot id: G7N9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9544:COX4I2
gene id: 9544:COX4I2
uniprot id: A0A8J8XNK6
uniprot id: F7E0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9544:DUS4L
gene id: 9544:DUS4L
uniprot id: A0A8J8XHC8
uniprot id: F7HK92
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9544:APTX
gene id: 9544:APTX
uniprot id: F7C3L9
uniprot id: H9YUS5
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9544:DLGAP3
gene id: 9544:DLGAP3
uniprot id: F7ATM3
names: Similarity
messages: Belongs to the SAPAP family.

9544:EDNRB
gene id: 9544:EDNRB
uniprot id: F7BXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LSM6
gene id: 9544:LSM6
uniprot id: A0A8J8Y1R6
uniprot id: F7GFC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9544:SUPT3H
gene id: 9544:SUPT3H
uniprot id: H9G0V2
names: Subcellular Location Annotation
messages: Nucleus

9544:WNT7A
gene id: 9544:WNT7A
uniprot id: F7HEW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:RXFP2
gene id: 9544:RXFP2
uniprot id: D3JXK7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PRKCG
gene id: 9544:PRKCG
uniprot id: F7H3B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

9544:MOGAT1
gene id: 9544:MOGAT1
uniprot id: G7N915
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC100426497
gene id: 9544:LOC100426497
uniprot id: F6YZT4
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:EPHA8
gene id: 9544:EPHA8
uniprot id: F7HEL6
names: Subcellular Location Annotation
messages: Membrane

9544:PPP1CB
gene id: 9544:PPP1CB
uniprot id: H9FWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9544:FMO5
gene id: 9544:FMO5
uniprot id: F6PUF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:CYP2D6
gene id: 9544:CYP2D6
uniprot id: Q6GUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:TMEM201
gene id: 9544:TMEM201
uniprot id: I2CWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9544:TLR9
gene id: 9544:TLR9
uniprot id: B3Y667
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Lysosome
messages: Membrane
messages: phagosome

9544:CDK7
gene id: 9544:CDK7
uniprot id: F6XZK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9544:CAMP
gene id: 9544:CAMP
uniprot id: Q9GLV5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After secretion onto the skin surface, the CAMP gene product is processed by a serine protease-dependent mechanism into multiple novel antimicrobial peptides distinct from and shorter than cathelicidin LL-37 (By similarity). These peptides show enhanced antimicrobial action, acquiring the ability to kill skin pathogens such as S.aureus, E.coli and C.albicans. These peptides have lost the ability to stimulate CXCL8/IL8 release from keratinocytes (By similarity). The peptides act synergistically, killing bacteria at lower concentrations when present together, and maintain activity at increased salt condition (By similarity).
messages: Antimicrobial peptide that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Causes membrane permeabilization by forming transmembrane pores (in vitro) (By similarity). Causes lysis of E.coli (By similarity). Exhibits antimicrobial activity against Gram-negative bacteria such as P.aeruginosa, S.typhimurium, E.aerogenes, E.coli and P.syringae, Gram-positive bacteria such as L.monocytogenes, S.epidermidis, S.pyogenes and S.aureus, as well as vancomycin-resistant enterococci (in vitro) (By similarity). Exhibits antimicrobial activity against methicillin-resistant S.aureus, P.mirabilis, and C.albicans in low-salt media, but not in media containing 100 mM NaCl (in vitro) (By similarity). Forms chiral supramolecular assemblies with quinolone signal (PQS) molecules of P.aeruginosa, which may lead to interference of bacterial quorum signaling and perturbance of bacterial biofilm formation (By similarity). May form supramolecular fiber-like assemblies on bacterial membranes (By similarity). Induces cytokine and chemokine producation as well as TNF/TNFA and CSF2/GMCSF production in normal human keratinocytes (By similarity). Exhibits hemolytic activity against red blood cells (By similarity).
messages: Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (By similarity). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (By similarity). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (By similarity).
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Monomer, homodimer or homotrimer (in vitro) (By similarity). Oligomerizes as tetra- or hexamer in solution (in vitro) (By similarity).
messages: Proteolytically cleaved by proteinase PRTN3 into antibacterial peptide LL-37 (By similarity). Proteolytically cleaved by cathepsin CTSG and neutrophil elastase ELANE (By similarity).
messages: Residues 17-29 of LL-37 represent the active core of the antimicrobial peptide. Forms ribbon-like fibrils and exhibits antibacterial activity against Gram-positive M.luteus (By similarity). Also exhibits antibacterial activity against Gram-negative E.coli and P.fluorescens (By similarity).
messages: Resistant to proteolytic degradation in solution, and when bound to both zwitterionic (mimicking mammalian membranes) and negatively charged membranes (mimicking bacterial membranes).
messages: Secreted
messages: The cathelin-like domain (CLD), which is the propeptide part, does not seem to exhibit auto-inhibitory function, as it does not inhibit the antibacterial activity of antibacterial peptide LL-37.
messages: Undergoes conformational change in the presence of lipid A, transitioning from a random coil to an alpha-helical structure.
messages: Vesicle

9544:XPA
gene id: 9544:XPA
uniprot id: A0A5F8AFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9544:NOL10
gene id: 9544:NOL10
uniprot id: A0A5K1VU09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9544:HPCAL4
gene id: 9544:HPCAL4
uniprot id: A0A8J8XF78
uniprot id: G7MG96
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9544:CDC42EP4
gene id: 9544:CDC42EP4
uniprot id: A0A8J8YDM3
uniprot id: F7F354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9544:DKK2
gene id: 9544:DKK2
uniprot id: A0A8J8YAL3
uniprot id: F7GS28
names: Similarity
messages: Belongs to the dickkopf family.

9544:PSMA3
gene id: 9544:PSMA3
uniprot id: A0A8J8YC79
uniprot id: F7E2S4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:S100A10
gene id: 9544:S100A10
uniprot id: A0A8J8XSG0
uniprot id: G7MDL9
uniprot id: P62504
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Belongs to the S-100 family.
messages: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with SCN10A (By similarity). Interacts with TASOR (By similarity).

9544:ANKRD13C
gene id: 9544:ANKRD13C
uniprot id: H9G084
names: Subcellular Location Annotation
messages: Membrane

9544:TOMM20
gene id: 9544:TOMM20
uniprot id: F7DT16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:JPH3
gene id: 9544:JPH3
uniprot id: H9FXK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9544:GPM6A
gene id: 9544:GPM6A
uniprot id: A0A1D5QPT8
uniprot id: A0A8J8YED2
uniprot id: G7MSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9544:ITFG1
gene id: 9544:ITFG1
uniprot id: F6RCT6
names: Similarity
messages: Belongs to the TIP family.

9544:MND1
gene id: 9544:MND1
uniprot id: F7CDA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9544:DDX5
gene id: 9544:DDX5
uniprot id: H9FQP4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9544:SERPINI1
gene id: 9544:SERPINI1
uniprot id: A0A8J8XMG4
uniprot id: F6V360
names: Similarity
messages: Belongs to the serpin family.

9544:CHST7
gene id: 9544:CHST7
uniprot id: F7CNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:PDS5A
gene id: 9544:PDS5A
uniprot id: H9ENX0
names: Similarity
messages: Belongs to the PDS5 family.

9544:INTU
gene id: 9544:INTU
uniprot id: F6VUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9544:HNRNPC
gene id: 9544:HNRNPC
uniprot id: H9FTS3
uniprot id: I0FI33
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9544:MOCS2
gene id: 9544:MOCS2
uniprot id: H9Z947
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9544:ANXA3
gene id: 9544:ANXA3
uniprot id: A0A8J8XX57
uniprot id: G7MSZ8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:CHRNA9
gene id: 9544:CHRNA9
uniprot id: F7F3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:RALYL
gene id: 9544:RALYL
uniprot id: A0A1D5R9N5
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9544:DPT
gene id: 9544:DPT
uniprot id: A0A8J8XHL3
uniprot id: G7MF99
names: Similarity
messages: Belongs to the dermatopontin family.

9544:SEC23A
gene id: 9544:SEC23A
uniprot id: A0A8J8YFE4
uniprot id: G7MXN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9544:B3GAT2
gene id: 9544:B3GAT2
uniprot id: A0A5F7ZC00
uniprot id: A0A5F8AKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:RBM12
gene id: 9544:RBM12
uniprot id: Q8SQ27
names: Subcellular Location Annotation
messages: Nucleus

9544:PFKFB2
gene id: 9544:PFKFB2
uniprot id: A0A1D5R0P3
uniprot id: F6XIF5
uniprot id: I2CY44
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9544:CPEB1
gene id: 9544:CPEB1
uniprot id: A0A1D5R0L8
names: Similarity
messages: Belongs to the RRM CPEB family.

9544:TNFSF13
gene id: 9544:TNFSF13
uniprot id: A0A1D5QCF7
uniprot id: A0A5F8ACU1
uniprot id: F7HGJ2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:GNB1
gene id: 9544:GNB1
uniprot id: A0A8J8XZ61
uniprot id: F7FXA9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:ZCCHC17
gene id: 9544:ZCCHC17
uniprot id: F7GXR2
names: Subcellular Location Annotation
messages: nucleolus

9544:ATF4
gene id: 9544:ATF4
uniprot id: F7GFP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9544:BEST3
gene id: 9544:BEST3
uniprot id: F6SEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9544:CD14
gene id: 9544:CD14
uniprot id: B3Y6B8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9544:JAK1
gene id: 9544:JAK1
uniprot id: F6YLX1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9544:GUCY1B1
gene id: 9544:GUCY1B1
uniprot id: A0A1D5QWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9544:NTRK3
gene id: 9544:NTRK3
uniprot id: F7D0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:FBXO34
gene id: 9544:FBXO34
uniprot id: A0A8J8XVM6
uniprot id: H9FWF4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9544:ACHE
gene id: 9544:ACHE
uniprot id: A0A5K1U1J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9544:ATP6AP2
gene id: 9544:ATP6AP2
uniprot id: A0A8J8YGK3
uniprot id: F7BK83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9544:NHSL2
gene id: 9544:NHSL2
uniprot id: A0A5F7ZQD2
names: Similarity
messages: Belongs to the NHS family.

9544:TBX3
gene id: 9544:TBX3
uniprot id: A0A8J8Y5K9
uniprot id: F6WW74
uniprot id: G7N5Q8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:COX7B
gene id: 9544:COX7B
uniprot id: H9Z2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SPTBN1
gene id: 9544:SPTBN1
uniprot id: F7FS44
uniprot id: H9YXU8
uniprot id: I0FIZ4
names: Similarity
messages: Belongs to the spectrin family.

9544:TNFSF11
gene id: 9544:TNFSF11
uniprot id: A0A8J8XHD7
uniprot id: F7F5R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9544:FAM151B
gene id: 9544:FAM151B
uniprot id: A0A1D5RGS8
names: Similarity
messages: Belongs to the FAM151 family.

9544:LAMP5
gene id: 9544:LAMP5
uniprot id: G7N2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9544:WRB
gene id: 9544:WRB
uniprot id: H9ZD81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:SERINC2
gene id: 9544:SERINC2
uniprot id: A0A5K1VD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9544:GNRH2
gene id: 9544:GNRH2
uniprot id: O97655
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9544:TERF2IP
gene id: 9544:TERF2IP
uniprot id: H9FW07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9544:EDN3
gene id: 9544:EDN3
uniprot id: A0A1D5QU72
uniprot id: F7FQK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9544:SRP68
gene id: 9544:SRP68
uniprot id: F7D5D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9544:BDNF
gene id: 9544:BDNF
uniprot id: A0A1D5QAT2
uniprot id: A0A8J8YBY4
uniprot id: F7F914
uniprot id: I2CTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9544:DOT1L
gene id: 9544:DOT1L
uniprot id: A0A5F8AS85
uniprot id: H9G0R7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Histone methyltransferase. Methylates 'Lys-79' of histone H3.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

9544:CLIC4
gene id: 9544:CLIC4
uniprot id: F6PP70
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9544:RPL22
gene id: 9544:RPL22
uniprot id: F7H615
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9544:FUNDC1
gene id: 9544:FUNDC1
uniprot id: F7EH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9544:RNASEH2B
gene id: 9544:RNASEH2B
uniprot id: H9FZT1
uniprot id: H9FZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9544:APOM
gene id: 9544:APOM
uniprot id: F7CSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9544:CPXM1
gene id: 9544:CPXM1
uniprot id: A0A8J8YRM4
uniprot id: G7N2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9544:GPR171
gene id: 9544:GPR171
uniprot id: F7HBT2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:VARS
gene id: 9544:VARS
uniprot id: A0A8J8XAC5
uniprot id: G7MRK4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:NLGN4Y
gene id: 9544:NLGN4Y
uniprot id: B8YE04
uniprot id: F7CFI2
uniprot id: H9EUX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9544:CCL4L1
gene id: 9544:CCL4L1
uniprot id: Q8HYQ2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Detected in peripheral blood mononuclear cells and lymph nodes.
messages: Homodimer. Interacts with CCR5 (By similarity).
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted
messages: Up-regulated in SIV or SHIV infected monkeys with decreased CD4+ T-cell count.

9544:IMP3
gene id: 9544:IMP3
uniprot id: F7GL33
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9544:EXOC2
gene id: 9544:EXOC2
uniprot id: H9ES04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9544:XIAP
gene id: 9544:XIAP
uniprot id: H9FTU3
names: Similarity
messages: Belongs to the IAP family.

9544:HOXA1
gene id: 9544:HOXA1
uniprot id: A0A8J8YAA6
uniprot id: F6Q6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9544:CAP2
gene id: 9544:CAP2
uniprot id: H9FNR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9544:CRHBP
gene id: 9544:CRHBP
uniprot id: A0A8J8Y622
uniprot id: F7DGB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9544:PCYOX1
gene id: 9544:PCYOX1
uniprot id: F7HQU2
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9544:NDUFB5
gene id: 9544:NDUFB5
uniprot id: A0A8J8YM54
uniprot id: F6ZQ85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:RAF1
gene id: 9544:RAF1
uniprot id: F6SWC0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9544:S1PR2
gene id: 9544:S1PR2
uniprot id: A0A8J8XRA6
uniprot id: F7HPM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9544:FKTN
gene id: 9544:FKTN
uniprot id: A0A5F7ZUZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9544:GNG12
gene id: 9544:GNG12
uniprot id: A0A8J8XIJ6
uniprot id: I0FMD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:APOBEC3C
gene id: 9544:APOBEC3C
uniprot id: B0LW74
names: Subcellular Location Annotation
messages: Cytoplasm

9544:P2RY2
gene id: 9544:P2RY2
uniprot id: F6QZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:C11H12orf65
gene id: 9544:C11H12orf65
uniprot id: A0A1D5Q6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9544:LOC106997862
gene id: 9544:LOC106997862
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:UFM1
gene id: 9544:UFM1
uniprot id: F6VE95
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9544:EIF4A2
gene id: 9544:EIF4A2
uniprot id: F7GUR7
uniprot id: G7MK70
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9544:SERPINF1
gene id: 9544:SERPINF1
uniprot id: F6ZGR2
names: Similarity
messages: Belongs to the serpin family.

9544:BRS3
gene id: 9544:BRS3
uniprot id: G7NRP5
uniprot id: Q6H2Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane
messages: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:DDX21
gene id: 9544:DDX21
uniprot id: H9G1S2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9544:SLC22A8
gene id: 9544:SLC22A8
uniprot id: A0A8J8Y3Q9
uniprot id: F7GJL4
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9544:HCST
gene id: 9544:HCST
uniprot id: Q8WNQ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAP10 family.
messages: Homodimer; Disulfide-linked. Heterohexamer composed of four subunits of HCST/DAP10 and two subunits of KLRK1. Interacts (via transmembrane domain) with KLRK1 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Interacts with PIK3R1 and GRB2. Interacts with CLEC5A. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). Interacts with CD300H (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST.
messages: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).

9544:TLE3
gene id: 9544:TLE3
uniprot id: H9EN36
uniprot id: H9ZCZ0
uniprot id: H9ZCZ1
uniprot id: H9ZCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9544:TRMT5
gene id: 9544:TRMT5
uniprot id: F7GSQ4
uniprot id: H9EXS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9544:AGPAT3
gene id: 9544:AGPAT3
uniprot id: H9FXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LSM1
gene id: 9544:LSM1
uniprot id: A0A8J8YJI8
uniprot id: G7MZ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9544:OGDH
gene id: 9544:OGDH
uniprot id: A0A1D5QHY1
uniprot id: A0A1D5RCY7
uniprot id: A0A8J8XX26
uniprot id: F7H508
uniprot id: G7MLD3
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9544:B3GAT3
gene id: 9544:B3GAT3
uniprot id: A0A1D5R236
uniprot id: A0A8J8YDB1
uniprot id: G7NCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:CNEP1R1
gene id: 9544:CNEP1R1
uniprot id: F6TD31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9544:GTF2A1
gene id: 9544:GTF2A1
uniprot id: I0FLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9544:ZNF263
gene id: 9544:ZNF263
uniprot id: H9Z417
names: Subcellular Location Annotation
messages: Nucleus

9544:HSD17B13
gene id: 9544:HSD17B13
uniprot id: A0A8J8YRE2
uniprot id: G7MTC9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:FAM72A
gene id: 9544:FAM72A
uniprot id: A0A8J8YB63
uniprot id: G7MER7
names: Similarity
messages: Belongs to the FAM72 family.

9544:CTSV
gene id: 9544:CTSV
uniprot id: G7NF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9544:FUBP1
gene id: 9544:FUBP1
uniprot id: H9G1C9
names: Subcellular Location Annotation
messages: Nucleus

9544:F5
gene id: 9544:F5
uniprot id: A0A1D5QJP4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9544:KEG06 p01
gene id: 9544:KEG06_p01
uniprot id: A0A088CFM7
uniprot id: Q6IYG6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9544:NIM1K
gene id: 9544:NIM1K
uniprot id: F7D9P3
uniprot id: G8F1C4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:LCN15
gene id: 9544:LCN15
uniprot id: A0A8J8XII7
uniprot id: F6QQQ8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:TSHR
gene id: 9544:TSHR
uniprot id: Q8HY53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9544:SDHAF1
gene id: 9544:SDHAF1
uniprot id: F6X7B7
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9544:CFL2
gene id: 9544:CFL2
uniprot id: A0A8J8YS11
uniprot id: G7MXF7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9544:YPEL2
gene id: 9544:YPEL2
uniprot id: A0A8J8XTF4
uniprot id: G7NHY7
names: Similarity
messages: Belongs to the yippee family.

9544:IK
gene id: 9544:IK
uniprot id: H9EPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9544:DENND5B
gene id: 9544:DENND5B
uniprot id: A0A5F8A6B2
uniprot id: A0A8J8XVA9
uniprot id: F7DNZ4
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RNFT2
gene id: 9544:RNFT2
uniprot id: A0A8J8XB73
uniprot id: F7D470
names: Subcellular Location Annotation
messages: Membrane

9544:E2F2
gene id: 9544:E2F2
uniprot id: F7H757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:LAMP2
gene id: 9544:LAMP2
uniprot id: F6TJH8
uniprot id: F7BCK9
uniprot id: F7BCN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9544:KCNJ16
gene id: 9544:KCNJ16
uniprot id: A0A1D5RBD6
uniprot id: A0A8J8YK71
uniprot id: F7BX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:PGD
gene id: 9544:PGD
uniprot id: F7GIV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9544:NT5E
gene id: 9544:NT5E
uniprot id: A0A8J8YQL6
uniprot id: F7GPZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9544:HSPA8
gene id: 9544:HSPA8
uniprot id: F6RLH5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:PPP3CB
gene id: 9544:PPP3CB
uniprot id: F6SFC6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9544:ERO1B
gene id: 9544:ERO1B
uniprot id: A0A1D5QS20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9544:LOC693513
gene id: 9544:LOC693513
uniprot id: F7HKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:UBE2I
gene id: 9544:UBE2I
uniprot id: H9ZD43
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:WNT10A
gene id: 9544:WNT10A
uniprot id: A0A5F7ZU66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:PRPSAP1
gene id: 9544:PRPSAP1
uniprot id: A0A8J8XIX7
uniprot id: G7NGX7
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9544:AXIN1
gene id: 9544:AXIN1
uniprot id: A0A5F7ZYG4
uniprot id: F6Y8U0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9544:KCNK13
gene id: 9544:KCNK13
uniprot id: A0A8J8XVB3
uniprot id: G7MYZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:FOXJ2
gene id: 9544:FOXJ2
uniprot id: A0A8J8YEJ7
uniprot id: G7N5W4
names: Subcellular Location Annotation
messages: Nucleus

9544:DENND5A
gene id: 9544:DENND5A
uniprot id: A0A5F8AQ23
uniprot id: F7HB53
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SCN11A
gene id: 9544:SCN11A
uniprot id: F7FVT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:TCEANC2
gene id: 9544:TCEANC2
uniprot id: F6YTA6
names: Subcellular Location Annotation
messages: Nucleus

9544:PSMB9
gene id: 9544:PSMB9
uniprot id: A0A8J8XMR4
uniprot id: F6UNF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:CAPN2
gene id: 9544:CAPN2
uniprot id: H9EQA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:TMOD3
gene id: 9544:TMOD3
uniprot id: A0A8J8Y580
uniprot id: F7C5M5
names: Subcellular Location Annotation
messages: cytoskeleton

9544:AIFM1
gene id: 9544:AIFM1
uniprot id: A0A8J8Y1W1
uniprot id: F7C728
uniprot id: F7C7I3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9544:BIRC3
gene id: 9544:BIRC3
uniprot id: A0A5F8A395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9544:PTGES3
gene id: 9544:PTGES3
uniprot id: H9EM56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9544:FAM193B
gene id: 9544:FAM193B
uniprot id: F7CPU2
uniprot id: F7G4H5
names: Similarity
messages: Belongs to the FAM193 family.

9544:TMA7
gene id: 9544:TMA7
uniprot id: A0A8J8XGR6
uniprot id: F7H2I7
names: Similarity
messages: Belongs to the TMA7 family.

9544:RPSA
gene id: 9544:RPSA
uniprot id: A0A8J8XYF1
uniprot id: F6U6B5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9544:SLC12A3
gene id: 9544:SLC12A3
uniprot id: F6QQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:SERPINB8
gene id: 9544:SERPINB8
uniprot id: H9YWZ7
names: Similarity
messages: Belongs to the serpin family.

9544:TGFA
gene id: 9544:TGFA
uniprot id: F7CHL7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC705226
gene id: 9544:LOC705226
uniprot id: F6RAP3
uniprot id: G7MT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9544:CES5A
gene id: 9544:CES5A
uniprot id: D0Z5M4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9544:TRPC5
gene id: 9544:TRPC5
uniprot id: A0A8J8YKZ5
uniprot id: F7CXM3
names: Subcellular Location Annotation
messages: Membrane

9544:LOC701667
gene id: 9544:LOC701667
uniprot id: F7HDL0
names: Similarity
messages: Belongs to the intermediate filament family.

9544:MAPK1IP1L
gene id: 9544:MAPK1IP1L
uniprot id: H9ET74
names: Similarity
messages: Belongs to the MISS family.

9544:SCFD2
gene id: 9544:SCFD2
uniprot id: F7H4G1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:CLSTN3
gene id: 9544:CLSTN3
uniprot id: A0A1D5QYE4
uniprot id: A0A8J8YNY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9544:TRIM45
gene id: 9544:TRIM45
uniprot id: A0A8J8YDC6
uniprot id: G7MFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9544:ADIPOR1
gene id: 9544:ADIPOR1
uniprot id: F7F197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:DHX15
gene id: 9544:DHX15
uniprot id: A0A8J8XNA6
uniprot id: F6YQX3
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9544:GTF2H5
gene id: 9544:GTF2H5
uniprot id: A0A8J8YQS1
uniprot id: F7FPD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9544:ARSI
gene id: 9544:ARSI
uniprot id: A0A8J8XWZ0
uniprot id: F7BMK9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:CDK8
gene id: 9544:CDK8
uniprot id: H9FNK1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HEXIM2
gene id: 9544:HEXIM2
uniprot id: A0A8J8YJX5
uniprot id: F6YS14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9544:LOC705843
gene id: 9544:LOC705843
uniprot id: A0A5F7ZPE8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:HNRNPH2
gene id: 9544:HNRNPH2
uniprot id: F7BG13
names: Subcellular Location Annotation
messages: nucleoplasm

9544:RETREG3
gene id: 9544:RETREG3
uniprot id: A0A1D5R8K0
uniprot id: A0A1D5R964
uniprot id: A0A8J8YB59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9544:ZKSCAN3
gene id: 9544:ZKSCAN3
uniprot id: A0A5F7ZY50
names: Subcellular Location Annotation
messages: Nucleus

9544:RHBG
gene id: 9544:RHBG
uniprot id: Q8WNQ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cytoplasmic vesicle membrane
messages: Functions as a specific ammonium transporter.
messages: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
messages: N-glycosylated.

9544:POLR1E
gene id: 9544:POLR1E
uniprot id: A0A5K1VSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9544:SLC2A3
gene id: 9544:SLC2A3
uniprot id: H9YVK0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9544:ACTRT2
gene id: 9544:ACTRT2
uniprot id: A0A8J8YR26
uniprot id: F7FHH3
names: Similarity
messages: Belongs to the actin family.

9544:GRB14
gene id: 9544:GRB14
uniprot id: F6QF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9544:SLC25A1
gene id: 9544:SLC25A1
uniprot id: H9FYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:QRFP
gene id: 9544:QRFP
uniprot id: A0A8J8XR83
uniprot id: F7EGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9544:CD79B
gene id: 9544:CD79B
uniprot id: H9ZFT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:MAPK6
gene id: 9544:MAPK6
uniprot id: F7GB31
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9544:PLA2G1B
gene id: 9544:PLA2G1B
uniprot id: F6TJ10
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9544:CDH11
gene id: 9544:CDH11
uniprot id: A0A8J8Y2W2
uniprot id: F7GFF0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:XKRX
gene id: 9544:XKRX
uniprot id: A0A8J8XTN1
uniprot id: F6YLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9544:PHKA1
gene id: 9544:PHKA1
uniprot id: H9YVJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9544:B9D1
gene id: 9544:B9D1
uniprot id: F7H5W8
names: Subcellular Location Annotation
messages: cilium basal body

9544:CD81
gene id: 9544:CD81
uniprot id: F6WY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:SEC11C
gene id: 9544:SEC11C
uniprot id: A0A1D5RIY6
uniprot id: A0A8J8XWT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RPS6KA5
gene id: 9544:RPS6KA5
uniprot id: H9EPT1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:IFNGR1
gene id: 9544:IFNGR1
uniprot id: A0A8J8YL07
uniprot id: F7HB25
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9544:PLPP2
gene id: 9544:PLPP2
uniprot id: H9G165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:YDJC
gene id: 9544:YDJC
uniprot id: H9EVG3
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9544:CFAP97
gene id: 9544:CFAP97
uniprot id: H9FXP3
names: Similarity
messages: Belongs to the CFAP97 family.

9544:KALRN
gene id: 9544:KALRN
uniprot id: A0A1D5QWV4
uniprot id: F6VU49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9544:MRPL52
gene id: 9544:MRPL52
uniprot id: A0A5K1UY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9544:CAMLG
gene id: 9544:CAMLG
uniprot id: A0A1D5R0B5
uniprot id: A0A8J8XX77
uniprot id: H9G0B7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9544:SDHC
gene id: 9544:SDHC
uniprot id: G7MEA1
uniprot id: I2CTM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9544:GNRH1
gene id: 9544:GNRH1
uniprot id: A0A8J8YIX6
uniprot id: G7N0Q8
uniprot id: P55247
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
messages: The precursor is cleaved by ACE, which removes the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone. The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.

9544:AKR1B1
gene id: 9544:AKR1B1
uniprot id: A0A8J8XER5
uniprot id: G7MME8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:LY6G5C
gene id: 9544:LY6G5C
uniprot id: Q863H0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: N-glycosylated.
messages: Secreted

9544:ST7
gene id: 9544:ST7
uniprot id: A0A1D5QPA9
uniprot id: F7E749
uniprot id: H9EN24
uniprot id: H9FZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9544:CLDN8
gene id: 9544:CLDN8
uniprot id: G7MN50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:TEC
gene id: 9544:TEC
uniprot id: A0A8J8Y2H2
uniprot id: G7MSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:ZDHHC3
gene id: 9544:ZDHHC3
uniprot id: A0A1D5QPT4
uniprot id: A0A5F7ZJZ7
uniprot id: A0A8J8XGC6
uniprot id: F7AYQ9
uniprot id: F7AYS4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:NCK2
gene id: 9544:NCK2
uniprot id: A0A5F8AJZ6
uniprot id: A0A8J8XPM7
uniprot id: F7D094
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9544:SLC7A4
gene id: 9544:SLC7A4
uniprot id: A0A8J8YB83
uniprot id: F6V927
names: Subcellular Location Annotation
messages: Membrane

9544:PMP2
gene id: 9544:PMP2
uniprot id: A0A1D5RDW1
uniprot id: A0A8J8Y7I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9544:SLC9A3
gene id: 9544:SLC9A3
uniprot id: F7GVI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9544:RNF170
gene id: 9544:RNF170
uniprot id: A0A8J8Y552
uniprot id: G7MZ83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:MED7
gene id: 9544:MED7
uniprot id: A0A8J8YBE8
uniprot id: F7GS62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9544:EID2B
gene id: 9544:EID2B
uniprot id: G7MPU7
names: Subcellular Location Annotation
messages: Nucleus

9544:CCNI
gene id: 9544:CCNI
uniprot id: F7GP05
names: Similarity
messages: Belongs to the cyclin family.

9544:ABHD3
gene id: 9544:ABHD3
uniprot id: F7B2I5
uniprot id: H9EUP8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9544:PRKD3
gene id: 9544:PRKD3
uniprot id: A0A1D5QG47
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9544:NNT
gene id: 9544:NNT
uniprot id: H9FS68
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9544:KIF1C
gene id: 9544:KIF1C
uniprot id: H9FNY6
uniprot id: I2CWB9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:IFI27L2
gene id: 9544:IFI27L2
uniprot id: A0A8J8XT25
uniprot id: G7MW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9544:LXN
gene id: 9544:LXN
uniprot id: F7C1T0
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9544:F9
gene id: 9544:F9
uniprot id: A8CZ27
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PTPN13
gene id: 9544:PTPN13
uniprot id: F6S1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9544:ZFYVE27
gene id: 9544:ZFYVE27
uniprot id: G7N0V1
uniprot id: I0FP43
uniprot id: I0FP44
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9544:PREP
gene id: 9544:PREP
uniprot id: A0A8J8Y318
uniprot id: H9FWT3
names: Similarity
messages: Belongs to the peptidase S9A family.

9544:LTBR
gene id: 9544:LTBR
uniprot id: A0A1D5QP89
uniprot id: F6V995
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PTGFR
gene id: 9544:PTGFR
uniprot id: A0A8J8XJB1
uniprot id: F7CGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SLC19A1
gene id: 9544:SLC19A1
uniprot id: A0A1D5QH58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

9544:TXNDC5
gene id: 9544:TXNDC5
uniprot id: A0A5F7ZE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:FGF21
gene id: 9544:FGF21
uniprot id: F6ZFI2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:ART5
gene id: 9544:ART5
uniprot id: A0A5F7ZIN0
uniprot id: G7NE76
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9544:REEP6
gene id: 9544:REEP6
uniprot id: I0FWF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9544:SH3PXD2A
gene id: 9544:SH3PXD2A
uniprot id: F7EWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9544:NDUFS4
gene id: 9544:NDUFS4
uniprot id: A0A8J8XAH3
uniprot id: F7AVF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9544:SNAPC3
gene id: 9544:SNAPC3
uniprot id: H9ZCP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9544:ATP6V1C1
gene id: 9544:ATP6V1C1
uniprot id: A0A1D5Q465
uniprot id: A0A8J8YM03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9544:GRK6
gene id: 9544:GRK6
uniprot id: A0A5F8A9L1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9544:NCOA7
gene id: 9544:NCOA7
uniprot id: A0A5F7ZL06
uniprot id: A0A5F8AC70
names: Similarity
messages: Belongs to the OXR1 family.

9544:YAF2
gene id: 9544:YAF2
uniprot id: F7G033
uniprot id: F7HRL7
names: Subcellular Location Annotation
messages: Nucleus

9544:DUSP26
gene id: 9544:DUSP26
uniprot id: A0A8J8XRC6
uniprot id: F6RW93
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9544:EMC9
gene id: 9544:EMC9
uniprot id: A0A8J8YP66
uniprot id: F7FF56
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9544:RNASEH1
gene id: 9544:RNASEH1
uniprot id: H9FSB3
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9544:SH2D1A
gene id: 9544:SH2D1A
uniprot id: A0A8J8XM45
uniprot id: G7NRC6
uniprot id: Q71S10
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity).
messages: Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Interacts with NTRK1, NTRK2 and NTRK3 (By similarity).

9544:IL1RN
gene id: 9544:IL1RN
uniprot id: A0A1D5Q1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9544:SMIM5
gene id: 9544:SMIM5
uniprot id: H9EW15
names: Subcellular Location Annotation
messages: Membrane

9544:RASGRP1
gene id: 9544:RASGRP1
uniprot id: F6TUV4
names: Similarity
messages: Belongs to the RASGRP family.

9544:MMS19
gene id: 9544:MMS19
uniprot id: A0A1D5QDM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9544:STUM
gene id: 9544:STUM
uniprot id: I2CYM1
names: Subcellular Location Annotation
messages: Membrane

9544:DEFB122
gene id: 9544:DEFB122
uniprot id: G7N559
uniprot id: Q5J5Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:CGAS
gene id: 9544:CGAS
uniprot id: A0A0F7J4C8
uniprot id: A0A1D5QFG4
names: Similarity
messages: Belongs to the mab-21 family.

9544:CD36
gene id: 9544:CD36
uniprot id: Q6J512
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9544:CITED1
gene id: 9544:CITED1
uniprot id: G7NS41
uniprot id: I0FRV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9544:CCT4
gene id: 9544:CCT4
uniprot id: H9FNT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:HAT1
gene id: 9544:HAT1
uniprot id: A0A8J8XV08
uniprot id: F7F2T1
uniprot id: G7N8B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9544:GADD45G
gene id: 9544:GADD45G
uniprot id: A0A8J8XV25
uniprot id: F7GZG4
names: Similarity
messages: Belongs to the GADD45 family.

9544:ALDH3A1
gene id: 9544:ALDH3A1
uniprot id: F7BG63
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:HIST1H1D
gene id: 9544:HIST1H1D
uniprot id: A0A8J8XML2
uniprot id: F7HR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:RBM5
gene id: 9544:RBM5
uniprot id: I0FNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9544:TCP1
gene id: 9544:TCP1
uniprot id: F6T521
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

9544:LOC106992273
gene id: 9544:LOC106992273
uniprot id: H9ZBB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CD4
gene id: 9544:CD4
uniprot id: A0A2Z5GD40
uniprot id: P16003
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
messages: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
messages: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.
messages: The Ig-like V-type domain mediates the interaction with MHCII.

9544:SLC41A1
gene id: 9544:SLC41A1
uniprot id: A0A8J8XIJ2
uniprot id: F7EEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9544:TMEM9B
gene id: 9544:TMEM9B
uniprot id: A0A5F8A7H0
uniprot id: H9EUG5
names: Similarity
messages: Belongs to the TMEM9 family.

9544:HOXD1
gene id: 9544:HOXD1
uniprot id: A0A5F8AUH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9544:DEFB123
gene id: 9544:DEFB123
uniprot id: G7N558
uniprot id: Q5J5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant expression in the male reproductive tract only. Expressed abundantly in testis, while expression in epididymis decreased gradually from caput to cauda.
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:STX1B
gene id: 9544:STX1B
uniprot id: H9EME4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9544:C10H20orf27
gene id: 9544:C10H20orf27
uniprot id: F7HNY8
uniprot id: G7N2V0
names: Similarity
messages: Belongs to the UPF0687 family.

9544:ACTR8
gene id: 9544:ACTR8
uniprot id: A0A8J8YQY5
uniprot id: F6SIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9544:HMBS
gene id: 9544:HMBS
uniprot id: A0A5K1V982
uniprot id: A0A8J8Y8A1
uniprot id: F6U3X9
names: Similarity
messages: Belongs to the HMBS family.

9544:CALB1
gene id: 9544:CALB1
uniprot id: A0A8J8YPV8
uniprot id: G7MZQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9544:UBALD1
gene id: 9544:UBALD1
uniprot id: F6RY82
names: Similarity
messages: Belongs to the UBALD family.

9544:PLPPR5
gene id: 9544:PLPPR5
uniprot id: F6WR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:CHRM4
gene id: 9544:CHRM4
uniprot id: A0A8J8YSA9
uniprot id: G7NDH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9544:SLITRK2
gene id: 9544:SLITRK2
uniprot id: A0A8J8XN12
uniprot id: G7NRX2
names: Similarity
messages: Belongs to the SLITRK family.

9544:CRELD1
gene id: 9544:CRELD1
uniprot id: F7HJU7
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC39A1
gene id: 9544:SLC39A1
uniprot id: F6VJG8
uniprot id: F7AMB0
names: Subcellular Location Annotation
messages: Membrane

9544:DOLK
gene id: 9544:DOLK
uniprot id: A0A8J8XLE6
uniprot id: F7HSL4
names: Similarity
messages: Belongs to the polyprenol kinase family.

9544:DDX6
gene id: 9544:DDX6
uniprot id: H9FQP5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:HOMEZ
gene id: 9544:HOMEZ
uniprot id: F7G4M2
names: Subcellular Location Annotation
messages: Nucleus

9544:CYSLTR1
gene id: 9544:CYSLTR1
uniprot id: F7AB41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:RIOK3
gene id: 9544:RIOK3
uniprot id: I2CTD8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9544:GGA3
gene id: 9544:GGA3
uniprot id: F7DH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9544:TSPAN15
gene id: 9544:TSPAN15
uniprot id: A0A8J8Y8K4
uniprot id: F6Q657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:OTP
gene id: 9544:OTP
uniprot id: A0A1D5QM91
names: Subcellular Location Annotation
messages: Nucleus

9544:NAV1
gene id: 9544:NAV1
uniprot id: H9G1G5
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9544:HOXC5
gene id: 9544:HOXC5
uniprot id: A0A8J8YG14
uniprot id: G7N762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:NINJ1
gene id: 9544:NINJ1
uniprot id: F7BWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9544:SERINC1
gene id: 9544:SERINC1
uniprot id: A0A8J8Y6V9
uniprot id: F6PRH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9544:HMGN4
gene id: 9544:HMGN4
uniprot id: A0A8J8XT83
uniprot id: F7B025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:MTMR8
gene id: 9544:MTMR8
uniprot id: F6ZSQ9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:PAQR8
gene id: 9544:PAQR8
uniprot id: A0A8J8XX02
uniprot id: F7FLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:ADHFE1
gene id: 9544:ADHFE1
uniprot id: F6T885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9544:LOC704498
gene id: 9544:LOC704498
uniprot id: G7MJZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9544:PSMB5
gene id: 9544:PSMB5
uniprot id: A0A8J8XR90
uniprot id: G7MX33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:ASRGL1
gene id: 9544:ASRGL1
uniprot id: A0A8J8YPW3
uniprot id: F6SYY2
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9544:SMAD9
gene id: 9544:SMAD9
uniprot id: F6YG89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:RAB27A
gene id: 9544:RAB27A
uniprot id: A0A8J8XKI9
uniprot id: F6PJI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9544:CABIN1
gene id: 9544:CABIN1
uniprot id: H9Z748
names: Subcellular Location Annotation
messages: Nucleus

9544:GK
gene id: 9544:GK
uniprot id: A0A1D5QW52
uniprot id: H9FSZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9544:SBF1
gene id: 9544:SBF1
uniprot id: H9FY86
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:GLDN
gene id: 9544:GLDN
uniprot id: G7MXB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CDYL2
gene id: 9544:CDYL2
uniprot id: A0A1D5RKF7
names: Subcellular Location Annotation
messages: Nucleus

9544:PYCARD
gene id: 9544:PYCARD
uniprot id: F7EZX3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9544:CPNE3
gene id: 9544:CPNE3
uniprot id: H9ESU0
names: Similarity
messages: Belongs to the copine family.

9544:SPIN3
gene id: 9544:SPIN3
uniprot id: A0A1D5R2G3
uniprot id: A0A8J8XD24
names: Similarity
messages: Belongs to the SPIN/STSY family.

9544:LOC706675
gene id: 9544:LOC706675
uniprot id: G7NDC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:GAMT
gene id: 9544:GAMT
uniprot id: H9EWR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9544:TMEM47
gene id: 9544:TMEM47
uniprot id: F6SCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9544:GPR89A
gene id: 9544:GPR89A
uniprot id: F7D013
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9544:ARPC3
gene id: 9544:ARPC3
uniprot id: F7H998
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9544:IDE
gene id: 9544:IDE
uniprot id: H9Z8G5
names: Similarity
messages: Belongs to the peptidase M16 family.

9544:TSPAN7
gene id: 9544:TSPAN7
uniprot id: A0A8J8XAA4
uniprot id: I2CXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:ANP32B
gene id: 9544:ANP32B
uniprot id: A0A1D5Q4B1
names: Similarity
messages: Belongs to the ANP32 family.

9544:EHF
gene id: 9544:EHF
uniprot id: A0A8J8YSG4
uniprot id: F6V4C9
uniprot id: F6V4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:GLS2
gene id: 9544:GLS2
uniprot id: F7H7H2
names: Similarity
messages: Belongs to the glutaminase family.

9544:PACSIN1
gene id: 9544:PACSIN1
uniprot id: A0A8J8Y0N1
uniprot id: G7MRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9544:CERS6
gene id: 9544:CERS6
uniprot id: F7CYG3
uniprot id: F7FW69
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:BEX1
gene id: 9544:BEX1
uniprot id: A0A8J8XHI6
uniprot id: F6U884
names: Similarity
messages: Belongs to the BEX family.

9544:USB1
gene id: 9544:USB1
uniprot id: A0A8J8YAF4
uniprot id: G7NPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9544:CA12
gene id: 9544:CA12
uniprot id: A0A1D5QX25
uniprot id: A0A8J8XEQ8
uniprot id: F7DLJ4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9544:CYorf15A
gene id: 9544:CYorf15A
uniprot id: B8YDZ9
names: Similarity
messages: Belongs to the taxilin family.

9544:SLC43A3
gene id: 9544:SLC43A3
uniprot id: F7BRN1
names: Subcellular Location Annotation
messages: Membrane

9544:TFAP2B
gene id: 9544:TFAP2B
uniprot id: F7HFW9
names: Similarity
messages: Belongs to the AP-2 family.

9544:INPP4A
gene id: 9544:INPP4A
uniprot id: I2CWY7
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9544:TPST2
gene id: 9544:TPST2
uniprot id: A0A1D5RIJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9544:KCNJ2
gene id: 9544:KCNJ2
uniprot id: A0A8J8Y7B3
uniprot id: G7NJD1
uniprot id: P63253
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
messages: S-nitrosylation increases the open probability and inward rectifying currents.

9544:EFNB3
gene id: 9544:EFNB3
uniprot id: A0A8J8XAX8
uniprot id: G7NIH1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:STK38
gene id: 9544:STK38
uniprot id: H9Z4Y8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:LPCAT2
gene id: 9544:LPCAT2
uniprot id: A0A1D5Q5F4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:CPSF7
gene id: 9544:CPSF7
uniprot id: A0A1D5QK95
uniprot id: F7DUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9544:OSBPL8
gene id: 9544:OSBPL8
uniprot id: A0A1D5R0T7
uniprot id: A0A5F7ZRI0
uniprot id: A0A8J8XEC6
uniprot id: G7N7Q0
uniprot id: H9EMX7
names: Similarity
messages: Belongs to the OSBP family.

9544:RPS6KA6
gene id: 9544:RPS6KA6
uniprot id: A0A5F7ZH62
uniprot id: A0A5F8AU61
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:HSPA13
gene id: 9544:HSPA13
uniprot id: I0FIJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9544:LCOR
gene id: 9544:LCOR
uniprot id: A0A8J8YBR6
uniprot id: G7N2N5
names: Subcellular Location Annotation
messages: Nucleus

9544:DLX5
gene id: 9544:DLX5
uniprot id: A0A8J8Y0B4
uniprot id: F6TV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9544:DERL3
gene id: 9544:DERL3
uniprot id: A0A5S6RAL0
uniprot id: G8F1D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9544:USP15
gene id: 9544:USP15
uniprot id: A0A5F8AGG6
uniprot id: F6QY38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9544:HVCN1
gene id: 9544:HVCN1
uniprot id: F6TBN6
uniprot id: F6TBP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9544:GFRA1
gene id: 9544:GFRA1
uniprot id: A0A5F7Z995
uniprot id: F7GPD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9544:TOB2
gene id: 9544:TOB2
uniprot id: A0A8J8XH36
uniprot id: F7HSS9
names: Similarity
messages: Belongs to the BTG family.

9544:SH3GL2
gene id: 9544:SH3GL2
uniprot id: A0A5F7ZEZ3
uniprot id: F7HCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9544:ST6GALNAC5
gene id: 9544:ST6GALNAC5
uniprot id: F6UEG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:USP10
gene id: 9544:USP10
uniprot id: H9YZC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9544:ADGRG3
gene id: 9544:ADGRG3
uniprot id: G7NPV2
names: Subcellular Location Annotation
messages: Membrane

9544:CKMT2
gene id: 9544:CKMT2
uniprot id: G7MV65
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9544:IRX3
gene id: 9544:IRX3
uniprot id: F7D0A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9544:CEMIP2
gene id: 9544:CEMIP2
uniprot id: A0A8J8YIN3
uniprot id: G7NGB0
names: Similarity
messages: Belongs to the CEMIP family.

9544:TMEM115
gene id: 9544:TMEM115
uniprot id: A0A8J8YB60
uniprot id: F7F5U5
names: Subcellular Location Annotation
messages: Membrane

9544:CIAO2B
gene id: 9544:CIAO2B
uniprot id: F7GLS5
names: Similarity
messages: Belongs to the MIP18 family.

9544:OOEP
gene id: 9544:OOEP
uniprot id: A0A8J8XCS7
uniprot id: F6X4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

9544:PRRT2
gene id: 9544:PRRT2
uniprot id: F6YBL7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:AHSA1
gene id: 9544:AHSA1
uniprot id: A0A1D5QXA8
uniprot id: A0A8J8XHG8
names: Similarity
messages: Belongs to the AHA1 family.

9544:INKA2
gene id: 9544:INKA2
uniprot id: A0A5F8AFS3
uniprot id: A0A8J8YCN7
uniprot id: G7MIH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9544:TSPAN14
gene id: 9544:TSPAN14
uniprot id: G7N219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:ELP6
gene id: 9544:ELP6
uniprot id: A0A5F7ZIT4
uniprot id: H9EXR4
names: Similarity
messages: Belongs to the ELP6 family.

9544:CRK
gene id: 9544:CRK
uniprot id: H9FQ57
names: Similarity
messages: Belongs to the CRK family.

9544:CD8B
gene id: 9544:CD8B
uniprot id: F7EXY4
names: Subcellular Location Annotation
messages: Membrane

9544:CRYGD
gene id: 9544:CRYGD
uniprot id: A0A8J8YEX0
uniprot id: F6PWY4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:CYP17A1
gene id: 9544:CYP17A1
uniprot id: Q5IFH9
uniprot id: Q8HYM9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9544:CYP2C18
gene id: 9544:CYP2C18
uniprot id: E0V8I5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:NUDT1
gene id: 9544:NUDT1
uniprot id: F7HP40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9544:CPEB4
gene id: 9544:CPEB4
uniprot id: A0A1D5R7M6
uniprot id: A0A5F7ZM15
uniprot id: A0A8J8YKD7
uniprot id: G7MU03
uniprot id: H9G045
names: Similarity
messages: Belongs to the RRM CPEB family.

9544:PTPRF
gene id: 9544:PTPRF
uniprot id: A0A5F7ZLB0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9544:PPBP
gene id: 9544:PPBP
uniprot id: A0A8J8XGV7
uniprot id: F6SCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:ASIC1
gene id: 9544:ASIC1
uniprot id: F7H4L2
names: Subcellular Location Annotation
messages: Membrane

9544:SCPEP1
gene id: 9544:SCPEP1
uniprot id: A0A8J8XU42
uniprot id: H9ZBZ0
names: Similarity
messages: Belongs to the peptidase S10 family.

9544:PGM2L1
gene id: 9544:PGM2L1
uniprot id: A0A5F7ZXR2
uniprot id: A0A8J8XFZ0
uniprot id: I2CTQ0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9544:LANCL1
gene id: 9544:LANCL1
uniprot id: A0A8J8YEH5
uniprot id: F7B2A9
names: Similarity
messages: Belongs to the LanC-like protein family.

9544:ABL1
gene id: 9544:ABL1
uniprot id: H9YUX8
uniprot id: I0FQI2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:LOC705133
gene id: 9544:LOC705133
uniprot id: G8F1F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TBXAS1
gene id: 9544:TBXAS1
uniprot id: A0A5F7ZQR3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:EDC3
gene id: 9544:EDC3
uniprot id: A0A8J8XQJ7
uniprot id: F7GKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9544:TPD52L1
gene id: 9544:TPD52L1
uniprot id: A0A5F7ZBT5
uniprot id: A0A5F8APT0
uniprot id: A0A8J8YGR1
uniprot id: G7MQK9
uniprot id: I0FMV0
uniprot id: I0FMV2
names: Similarity
messages: Belongs to the TPD52 family.

9544:CFTR
gene id: 9544:CFTR
uniprot id: Q00553
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9544:POLH
gene id: 9544:POLH
uniprot id: F7DMW1
names: Subcellular Location Annotation
messages: Nucleus

9544:BMT2
gene id: 9544:BMT2
uniprot id: A0A8J8XVT5
uniprot id: G7MM54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9544:IFRD1
gene id: 9544:IFRD1
uniprot id: H9Z8I1
names: Similarity
messages: Belongs to the IFRD family.

9544:TMEM88
gene id: 9544:TMEM88
uniprot id: A0A8J8YJ17
uniprot id: F7GYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9544:SLC15A3
gene id: 9544:SLC15A3
uniprot id: F7G7B5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9544:CTSC
gene id: 9544:CTSC
uniprot id: Q3YAN9
names: Similarity
messages: Belongs to the peptidase C1 family.

9544:SMARCD1
gene id: 9544:SMARCD1
uniprot id: A0A1D5REM3
uniprot id: F7HTY2
names: Similarity
messages: Belongs to the SMARCD family.

9544:ST13
gene id: 9544:ST13
uniprot id: H9FYX3
names: Similarity
messages: Belongs to the FAM10 family.

9544:TAC1
gene id: 9544:TAC1
uniprot id: F6VX78
uniprot id: H9FYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9544:SKIL
gene id: 9544:SKIL
uniprot id: A0A8J8XFE5
uniprot id: G7MJB2
names: Similarity
messages: Belongs to the SKI family.

9544:FAM126B
gene id: 9544:FAM126B
uniprot id: A0A5F7ZDS5
uniprot id: A0A5F8AFC2
uniprot id: A0A8J8XXT9
uniprot id: F6VFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:TOP3A
gene id: 9544:TOP3A
uniprot id: H9EWR7
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9544:FAM241B
gene id: 9544:FAM241B
uniprot id: H9FR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9544:AQP4
gene id: 9544:AQP4
uniprot id: A0A1D5RFU8
uniprot id: A0A8J8YNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:MRPL2
gene id: 9544:MRPL2
uniprot id: F7G0Y5
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9544:SCNM1
gene id: 9544:SCNM1
uniprot id: A0A8J8YB23
uniprot id: F6PSF1
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9544:SMC3
gene id: 9544:SMC3
uniprot id: A0A8J8YBH8
uniprot id: G7N144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9544:ALX1
gene id: 9544:ALX1
uniprot id: A0A5F7ZQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9544:PTEN
gene id: 9544:PTEN
uniprot id: H9YWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9544:VANGL2
gene id: 9544:VANGL2
uniprot id: A0A8J8XIN7
uniprot id: F6WWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9544:HOOK3
gene id: 9544:HOOK3
uniprot id: H9EMU3
uniprot id: H9G0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:CDC42SE2
gene id: 9544:CDC42SE2
uniprot id: A0A8J8XNT0
uniprot id: G7MTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9544:NAT10
gene id: 9544:NAT10
uniprot id: A0A1D5Q9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9544:TRAPPC4
gene id: 9544:TRAPPC4
uniprot id: H9EPR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9544:ERGIC2
gene id: 9544:ERGIC2
uniprot id: H9ET96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9544:RPS26
gene id: 9544:RPS26
uniprot id: F7HQQ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9544:PBX2
gene id: 9544:PBX2
uniprot id: F6RF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:TAGLN
gene id: 9544:TAGLN
uniprot id: A0A8J8XWT2
uniprot id: F6WXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9544:TPM3
gene id: 9544:TPM3
uniprot id: A0A1D5QKL3
uniprot id: A0A5K1UXI5
uniprot id: A0A5K1VBZ1
uniprot id: F6VQX6
uniprot id: H9EN00
uniprot id: H9EN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:DSC3
gene id: 9544:DSC3
uniprot id: F7DB50
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9544:MTERF1
gene id: 9544:MTERF1
uniprot id: A0A5F8AK76
uniprot id: A0A8J8YR68
uniprot id: H9FZW3
names: Similarity
messages: Belongs to the mTERF family.

9544:PRDM1
gene id: 9544:PRDM1
uniprot id: A0A1D5QYV9
uniprot id: G7MQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9544:ABI3
gene id: 9544:ABI3
uniprot id: G7NHE5
names: Similarity
messages: Belongs to the ABI family.

9544:UTP25
gene id: 9544:UTP25
uniprot id: F7HP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9544:TMEM192
gene id: 9544:TMEM192
uniprot id: A0A8J8Y777
uniprot id: G7MS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9544:B3GALNT1
gene id: 9544:B3GALNT1
uniprot id: A0A8J8XUB5
uniprot id: F6UCJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:CTBP1
gene id: 9544:CTBP1
uniprot id: A0A1D5RJE7
uniprot id: A0A5F8AIY0
uniprot id: H9Z5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9544:TNFRSF1B
gene id: 9544:TNFRSF1B
uniprot id: H9ZD01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:BCAR1
gene id: 9544:BCAR1
uniprot id: A0A5F8AK84
uniprot id: I0FWM3
uniprot id: I0FWM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9544:PRND
gene id: 9544:PRND
uniprot id: A0A8J8Y3I9
uniprot id: A2BDH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9544:CASD1
gene id: 9544:CASD1
uniprot id: F7G2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9544:CAPZA1
gene id: 9544:CAPZA1
uniprot id: H9G0D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9544:IMPACT
gene id: 9544:IMPACT
uniprot id: F6RUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9544:RPL10L
gene id: 9544:RPL10L
uniprot id: A0A8J8Y6K7
uniprot id: G7MXP3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9544:CD200
gene id: 9544:CD200
uniprot id: A0A5F7ZNR7
uniprot id: H9EXH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:SNRPG
gene id: 9544:SNRPG
uniprot id: H9FNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9544:PIGS
gene id: 9544:PIGS
uniprot id: F6V7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:KIF2A
gene id: 9544:KIF2A
uniprot id: F6X5C6
uniprot id: H9EMN7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:SORBS2
gene id: 9544:SORBS2
uniprot id: I0FVR5
names: Subcellular Location Annotation
messages: focal adhesion

9544:THNSL1
gene id: 9544:THNSL1
uniprot id: F7H191
names: Similarity
messages: Belongs to the threonine synthase family.

9544:PUS3
gene id: 9544:PUS3
uniprot id: G7NCX7
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9544:SLC52A1
gene id: 9544:SLC52A1
uniprot id: F6U0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9544:HADHA
gene id: 9544:HADHA
uniprot id: I0FL67
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9544:CLK4
gene id: 9544:CLK4
uniprot id: A0A1D5RIS4
uniprot id: A0A8J8XAT3
uniprot id: F7GB49
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:ELAVL1
gene id: 9544:ELAVL1
uniprot id: A0A8J8YP06
uniprot id: F7HS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9544:AMELX
gene id: 9544:AMELX
uniprot id: A5JJS8
names: Similarity
messages: Belongs to the amelogenin family.

9544:PDGFB
gene id: 9544:PDGFB
uniprot id: A0A1D5Q4I7
uniprot id: A0A8J8XHM2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9544:LOC713991
gene id: 9544:LOC713991
uniprot id: F7FX28
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9544:MCCC2
gene id: 9544:MCCC2
uniprot id: H9EWW4
names: Similarity
messages: Belongs to the AccD/PCCB family.

9544:RFC2
gene id: 9544:RFC2
uniprot id: A0A8J8XRZ4
uniprot id: F7HAF1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9544:NEO1
gene id: 9544:NEO1
uniprot id: F6X4J3
uniprot id: F7GQ62
uniprot id: H9FUU9
uniprot id: H9FUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9544:DCP1B
gene id: 9544:DCP1B
uniprot id: A0A5F8A4V4
names: Similarity
messages: Belongs to the DCP1 family.

9544:SRP14
gene id: 9544:SRP14
uniprot id: I0FUH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9544:ATE1
gene id: 9544:ATE1
uniprot id: A0A5F7ZQA6
uniprot id: H9FP82
uniprot id: H9FP83
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9544:CDCA7
gene id: 9544:CDCA7
uniprot id: A0A1D5Q2X9
uniprot id: A0A1D5QA66
uniprot id: A0A8J8XYN9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:KIF20A
gene id: 9544:KIF20A
uniprot id: A0A8J8YRF8
uniprot id: G7MUW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:NR2F6
gene id: 9544:NR2F6
uniprot id: F6Z4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:EDC4
gene id: 9544:EDC4
uniprot id: A0A5F7ZFU7
uniprot id: F7HN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9544:MTUS1
gene id: 9544:MTUS1
uniprot id: A0A1D5Q3J5
uniprot id: F6Q3W3
uniprot id: F6RQ82
uniprot id: H9EW78
uniprot id: H9FXM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9544:POU4F3
gene id: 9544:POU4F3
uniprot id: F6XDC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9544:KHDC1
gene id: 9544:KHDC1
uniprot id: F6YLS6
names: Similarity
messages: Belongs to the KHDC1 family.

9544:RPL24
gene id: 9544:RPL24
uniprot id: A0A8J8YIX2
uniprot id: G7MK26
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9544:DDT
gene id: 9544:DDT
uniprot id: H9H305
names: Similarity
messages: Belongs to the MIF family.

9544:MTMR12
gene id: 9544:MTMR12
uniprot id: A0A5F8AS72
uniprot id: F7HMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9544:STAT4
gene id: 9544:STAT4
uniprot id: H9YWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:LOC107000794
gene id: 9544:LOC107000794
uniprot id: F7AE93
names: Similarity
messages: Belongs to the LCE family.

9544:HOPX
gene id: 9544:HOPX
uniprot id: F7EU22
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC35C1
gene id: 9544:SLC35C1
uniprot id: A0A8J8Y415
uniprot id: F6T786
uniprot id: F7HH07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9544:GK2
gene id: 9544:GK2
uniprot id: A0A5K1USH9
uniprot id: A0A8J8Y1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9544:GPR15
gene id: 9544:GPR15
uniprot id: O97663
uniprot id: Q09J08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Probable chemokine receptor. SIV-1 coreceptor.

9544:TRIM33
gene id: 9544:TRIM33
uniprot id: H9Z9X5
uniprot id: H9Z9X6
names: Subcellular Location Annotation
messages: Nucleus

9544:CA3
gene id: 9544:CA3
uniprot id: F6TQ33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9544:TMEM254
gene id: 9544:TMEM254
uniprot id: A0A5F7ZYZ6
names: Subcellular Location Annotation
messages: Membrane

9544:PHB2
gene id: 9544:PHB2
uniprot id: H9FPI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9544:TAS2R8
gene id: 9544:TAS2R8
uniprot id: Q645T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:LEF1
gene id: 9544:LEF1
uniprot id: A0A1D5Q829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9544:TEKT1
gene id: 9544:TEKT1
uniprot id: G7NI69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9544:KDM5D
gene id: 9544:KDM5D
uniprot id: H9G0C9
uniprot id: H9ZE34
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9544:IRF2BP2
gene id: 9544:IRF2BP2
uniprot id: H9Z8K7
uniprot id: H9Z8K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9544:PPAN
gene id: 9544:PPAN
uniprot id: A0A8J8Y9T7
uniprot id: G7NKY9
names: Subcellular Location Annotation
messages: nucleolus

9544:SLC39A13
gene id: 9544:SLC39A13
uniprot id: A0A1D5QXH1
uniprot id: F6T5L6
names: Subcellular Location Annotation
messages: Membrane

9544:RPL26
gene id: 9544:RPL26
uniprot id: A0A8J8YMZ4
uniprot id: F7F4S1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9544:FTH1
gene id: 9544:FTH1
uniprot id: F7F2L7
uniprot id: Q9GMG9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:EREG
gene id: 9544:EREG
uniprot id: A0A8J8XDA6
uniprot id: F7D8Y3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DEDD2
gene id: 9544:DEDD2
uniprot id: H9FQN0
names: Subcellular Location Annotation
messages: nucleolus

9544:NFS1
gene id: 9544:NFS1
uniprot id: F7CHF9
uniprot id: G7N4Y5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9544:RPS23
gene id: 9544:RPS23
uniprot id: A0A1D5QU28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9544:GPSM2
gene id: 9544:GPSM2
uniprot id: A0A5F7ZC43
uniprot id: H9FTK2
names: Similarity
messages: Belongs to the GPSM family.

9544:SART3
gene id: 9544:SART3
uniprot id: A0A8J8XQ02
uniprot id: H9ERJ3
names: Subcellular Location Annotation
messages: nucleoplasm

9544:C5AR1
gene id: 9544:C5AR1
uniprot id: F7H5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9544:INHBC
gene id: 9544:INHBC
uniprot id: A0A8J8Y604
uniprot id: F7H9S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9544:MED11
gene id: 9544:MED11
uniprot id: A0A8J8XBM4
uniprot id: F7CJM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:SLC25A33
gene id: 9544:SLC25A33
uniprot id: A0A1D5R948
uniprot id: H9G0N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:LOC721299
gene id: 9544:LOC721299
uniprot id: A0A5F8ACJ4
names: Similarity
messages: Belongs to the actin family.

9544:SFPQ
gene id: 9544:SFPQ
uniprot id: F6SSM0
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:OVOL2
gene id: 9544:OVOL2
uniprot id: I2CYC8
names: Subcellular Location Annotation
messages: Nucleus

9544:FAM229A
gene id: 9544:FAM229A
uniprot id: F6YM49
names: Similarity
messages: Belongs to the FAM229 family.

9544:VILL
gene id: 9544:VILL
uniprot id: F6SRR3
names: Similarity
messages: Belongs to the villin/gelsolin family.

9544:RPRD1A
gene id: 9544:RPRD1A
uniprot id: A0A8J8XN31
uniprot id: F6ZTW1
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9544:LOC707555
gene id: 9544:LOC707555
uniprot id: F7FAI7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9544:LOC704249
gene id: 9544:LOC704249
uniprot id: F6RXA0
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9544:XRN1
gene id: 9544:XRN1
uniprot id: F6WU61
uniprot id: F7APA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9544:PSMC4
gene id: 9544:PSMC4
uniprot id: A0A8J8YJH0
uniprot id: F7HIL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9544:FZD7
gene id: 9544:FZD7
uniprot id: A0A1D5Q0F6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:RPL27A
gene id: 9544:RPL27A
uniprot id: F7EMH2
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9544:ERBB3
gene id: 9544:ERBB3
uniprot id: G7N7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9544:ALDOC
gene id: 9544:ALDOC
uniprot id: A0A8J8Y737
uniprot id: G7NGJ8
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9544:TLR1
gene id: 9544:TLR1
uniprot id: B3Y611
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9544:OAZ1
gene id: 9544:OAZ1
uniprot id: F7EM01
names: Similarity
messages: Belongs to the ODC antizyme family.

9544:SUMO3
gene id: 9544:SUMO3
uniprot id: F7HD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9544:CTSD
gene id: 9544:CTSD
uniprot id: A0A5F8ABN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9544:PAGE1
gene id: 9544:PAGE1
uniprot id: F7CNQ5
names: Similarity
messages: Belongs to the GAGE family.

9544:SERPINA4
gene id: 9544:SERPINA4
uniprot id: A0A5F7ZU91
names: Similarity
messages: Belongs to the serpin family.

9544:FITM2
gene id: 9544:FITM2
uniprot id: A0A8J8Y5E9
uniprot id: F7HI34
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:NSMCE2
gene id: 9544:NSMCE2
uniprot id: H9Z7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9544:LHX6
gene id: 9544:LHX6
uniprot id: A0A1D5QBK8
uniprot id: A0A1D5RDV1
names: Subcellular Location Annotation
messages: Nucleus

9544:DLX6
gene id: 9544:DLX6
uniprot id: A0A1D5QLL4
names: Subcellular Location Annotation
messages: Nucleus

9544:MAP3K7
gene id: 9544:MAP3K7
uniprot id: F7H6S1
uniprot id: F7H6S6
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9544:SLC19A2
gene id: 9544:SLC19A2
uniprot id: I0FNI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9544:TPD52
gene id: 9544:TPD52
uniprot id: A0A5F7ZU92
uniprot id: A0A5F8AQW7
uniprot id: G7MZM0
uniprot id: I0FLD4
names: Similarity
messages: Belongs to the TPD52 family.

9544:PDLIM3
gene id: 9544:PDLIM3
uniprot id: F6Q4Z5
uniprot id: G7MSF0
names: Subcellular Location Annotation
messages: Z line

9544:LOC695427
gene id: 9544:LOC695427
uniprot id: A0A8J8Y153
uniprot id: F7BRX2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:NPPA
gene id: 9544:NPPA
uniprot id: F7CD36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9544:AGPAT1
gene id: 9544:AGPAT1
uniprot id: A0A8J8YA22
uniprot id: F6V4S7
uniprot id: F7HF22
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9544:RPTOR
gene id: 9544:RPTOR
uniprot id: H9EN45
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9544:TFDP1
gene id: 9544:TFDP1
uniprot id: H9FZ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:C20H16orf72
gene id: 9544:C20H16orf72
uniprot id: H9Z817
names: Similarity
messages: Belongs to the TAPR1 family.

9544:APOD
gene id: 9544:APOD
uniprot id: A0A8J8YFT1
uniprot id: F7FST1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9544:HSD17B6
gene id: 9544:HSD17B6
uniprot id: A0A8J8YGN1
uniprot id: F7A368
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:PRMT5
gene id: 9544:PRMT5
uniprot id: I0FNE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9544:GJB1
gene id: 9544:GJB1
uniprot id: A0A8J8XJS0
uniprot id: G7NRV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:FAM126A
gene id: 9544:FAM126A
uniprot id: H9ZEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:PHF19
gene id: 9544:PHF19
uniprot id: A0A1D5QU71
uniprot id: A0A8J8YIB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:ARHGEF1
gene id: 9544:ARHGEF1
uniprot id: A0A5F8A6M7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9544:PPP1R1B
gene id: 9544:PPP1R1B
uniprot id: F7HE42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9544:METTL14
gene id: 9544:METTL14
uniprot id: A0A8J8XV69
uniprot id: G7MRV0
names: Similarity
messages: Belongs to the MT-A70-like family.

9544:CRX
gene id: 9544:CRX
uniprot id: A0A5F7ZEA9
names: Subcellular Location Annotation
messages: Nucleus

9544:OR52N4
gene id: 9544:OR52N4
uniprot id: G7NE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:USP13
gene id: 9544:USP13
uniprot id: F7EMP5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:WDR82
gene id: 9544:WDR82
uniprot id: F7HSB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9544:ABCC2
gene id: 9544:ABCC2
uniprot id: Q95L75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9544:TMEM175
gene id: 9544:TMEM175
uniprot id: A0A5F8AKN0
uniprot id: F7HE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9544:EMC8
gene id: 9544:EMC8
uniprot id: A0A8J8Y9C4
uniprot id: F7HCZ6
uniprot id: H9Z0Z6
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9544:NDUFAB1
gene id: 9544:NDUFAB1
uniprot id: F7AF75
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9544:RPP14
gene id: 9544:RPP14
uniprot id: G8F1P7
uniprot id: H9FP84
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9544:WDR91
gene id: 9544:WDR91
uniprot id: H9FTE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:CCNH
gene id: 9544:CCNH
uniprot id: A0A8J8YPU1
uniprot id: G7MV81
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9544:AIDA
gene id: 9544:AIDA
uniprot id: H9FYK5
names: Similarity
messages: Belongs to the AIDA family.

9544:MYO5A
gene id: 9544:MYO5A
uniprot id: A0A1D5Q1J3
uniprot id: F6QDX8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:JUNB
gene id: 9544:JUNB
uniprot id: H9Z2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9544:POFUT2
gene id: 9544:POFUT2
uniprot id: I0FGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9544:LLPH
gene id: 9544:LLPH
uniprot id: A0A8J8XBA6
uniprot id: F6TQE1
names: Similarity
messages: Belongs to the learning-associated protein family.

9544:POLR3H
gene id: 9544:POLR3H
uniprot id: A0A8J8XGD0
uniprot id: F7BKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9544:MAOA
gene id: 9544:MAOA
uniprot id: F7D3I3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9544:MTR
gene id: 9544:MTR
uniprot id: A0A8J8YAH3
uniprot id: G7MFM9
uniprot id: I0FRW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9544:LGI2
gene id: 9544:LGI2
uniprot id: A0A5F8ANT9
names: Subcellular Location Annotation
messages: Secreted

9544:PKIA
gene id: 9544:PKIA
uniprot id: A0A8J8XFU5
uniprot id: F6Y6J6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9544:SEZ6L2
gene id: 9544:SEZ6L2
uniprot id: G7NQI5
uniprot id: H9FSV3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TMEM41B
gene id: 9544:TMEM41B
uniprot id: A0A8J8YKX8
uniprot id: G7MZB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9544:MEMO1
gene id: 9544:MEMO1
uniprot id: H9EQ09
names: Similarity
messages: Belongs to the MEMO1 family.

9544:CCNYL1
gene id: 9544:CCNYL1
uniprot id: F7AUG1
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9544:KRTAP3-1
gene id: 9544:KRTAP3-1
uniprot id: G7NIA8
names: Subunit
messages: Interacts with hair keratins.

9544:MVB12A
gene id: 9544:MVB12A
uniprot id: H9ETI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:ATP5IF1
gene id: 9544:ATP5IF1
uniprot id: A0A8J8XI36
uniprot id: F6ZXX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9544:PDE6D
gene id: 9544:PDE6D
uniprot id: A0A5F7ZIE3
uniprot id: A0A8J8XXR7
uniprot id: F7BMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9544:RIMKLB
gene id: 9544:RIMKLB
uniprot id: H9EPS3
names: Similarity
messages: Belongs to the RimK family.

9544:OIP5
gene id: 9544:OIP5
uniprot id: A0A8J8XU99
uniprot id: F7E2E5
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9544:CXCL3
gene id: 9544:CXCL3
uniprot id: Q8HXZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:AKAP8
gene id: 9544:AKAP8
uniprot id: F7DSP9
names: Similarity
messages: Belongs to the AKAP95 family.

9544:STARD3NL
gene id: 9544:STARD3NL
uniprot id: F6U9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:METTL26
gene id: 9544:METTL26
uniprot id: H9G0Q7
names: Similarity
messages: Belongs to the UPF0585 family.

9544:EMP3
gene id: 9544:EMP3
uniprot id: A0A8J8YAV2
uniprot id: F7H5H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9544:NTNG2
gene id: 9544:NTNG2
uniprot id: H9G0U9
uniprot id: I2CYB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PHYHIPL
gene id: 9544:PHYHIPL
uniprot id: A0A5F7ZJK7
uniprot id: H9EM71
names: Similarity
messages: Belongs to the PHYHIP family.

9544:ALKAL1
gene id: 9544:ALKAL1
uniprot id: A0A8J8Y519
uniprot id: F6VMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9544:SYN1
gene id: 9544:SYN1
uniprot id: H9EU25
uniprot id: H9EU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9544:LOC694887
gene id: 9544:LOC694887
uniprot id: F7B4W4
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:VPS25
gene id: 9544:VPS25
uniprot id: A0A8J8XTD2
uniprot id: F6UGE3
names: Similarity
messages: Belongs to the VPS25 family.

9544:OR10Q1
gene id: 9544:OR10Q1
uniprot id: A0A5F8A795
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SLC35F2
gene id: 9544:SLC35F2
uniprot id: A0A8J8Y2V3
uniprot id: G7NBT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9544:PHACTR4
gene id: 9544:PHACTR4
uniprot id: H9ZCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9544:ENSA
gene id: 9544:ENSA
uniprot id: H9EM77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9544:PLCB2
gene id: 9544:PLCB2
uniprot id: H9YV70
uniprot id: H9ZA60
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9544:MAP2K5
gene id: 9544:MAP2K5
uniprot id: A0A1D5Q0Z4
uniprot id: H9EPL8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:TRIP13
gene id: 9544:TRIP13
uniprot id: F7G4N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9544:DBNL
gene id: 9544:DBNL
uniprot id: A0A1D5REU8
uniprot id: H9FTD9
uniprot id: H9FTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

9544:HTR6
gene id: 9544:HTR6
uniprot id: A0A5F7ZDI3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:TUT7
gene id: 9544:TUT7
uniprot id: H9FZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9544:MRGPRX2
gene id: 9544:MRGPRX2
uniprot id: Q4QXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.

9544:STXBP5
gene id: 9544:STXBP5
uniprot id: F7GIA1
uniprot id: F7HJA2
uniprot id: H9FQ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:FTMT
gene id: 9544:FTMT
uniprot id: F7DMG0
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:ACYP2
gene id: 9544:ACYP2
uniprot id: A0A1D5RJS7
names: Similarity
messages: Belongs to the acylphosphatase family.

9544:PGM1
gene id: 9544:PGM1
uniprot id: A0A5F8A487
uniprot id: A0A8J8YFF9
uniprot id: F7G9Y1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9544:FGF11
gene id: 9544:FGF11
uniprot id: A0A7U3L4F8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:TSEN2
gene id: 9544:TSEN2
uniprot id: A0A5K1TVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9544:TMEM126B
gene id: 9544:TMEM126B
uniprot id: A0A8J8XM76
uniprot id: F6WC76
names: Subcellular Location Annotation
messages: Membrane

9544:MEF2C
gene id: 9544:MEF2C
uniprot id: A0A8J8Y518
uniprot id: G7MV83
uniprot id: H9FUJ7
uniprot id: H9Z924
uniprot id: H9Z925
names: Subcellular Location Annotation
messages: Nucleus

9544:TCEA3
gene id: 9544:TCEA3
uniprot id: I0FI55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9544:COMTD1
gene id: 9544:COMTD1
uniprot id: H9Z547
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9544:SLC45A3
gene id: 9544:SLC45A3
uniprot id: A0A8J8YB70
uniprot id: F6XTN2
names: Subcellular Location Annotation
messages: Membrane

9544:LIN52
gene id: 9544:LIN52
uniprot id: F7E2D4
names: Similarity
messages: Belongs to the lin-52 family.

9544:CCNF
gene id: 9544:CCNF
uniprot id: H9YXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: centriole
messages: perinuclear region

9544:KIF2C
gene id: 9544:KIF2C
uniprot id: A0A8J8XB83
uniprot id: G7MGN3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:CTNNBIP1
gene id: 9544:CTNNBIP1
uniprot id: H9FXE4
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9544:ADRA2A
gene id: 9544:ADRA2A
uniprot id: A0A1D5Q7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CCDC103
gene id: 9544:CCDC103
uniprot id: G7NJ40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9544:TCTA
gene id: 9544:TCTA
uniprot id: A0A8J8YR35
uniprot id: F7DH74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9544:FIGN
gene id: 9544:FIGN
uniprot id: F7HD85
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:PPP1R15A
gene id: 9544:PPP1R15A
uniprot id: A0A1D5R262
names: Similarity
messages: Belongs to the PPP1R15 family.

9544:CNNM2
gene id: 9544:CNNM2
uniprot id: A0A5F8AU49
uniprot id: F6RSX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9544:CIAPIN1
gene id: 9544:CIAPIN1
uniprot id: H9FXF1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9544:ADAMTS9
gene id: 9544:ADAMTS9
uniprot id: F7H0I0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:TMEM54
gene id: 9544:TMEM54
uniprot id: F7HU94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9544:MZT1
gene id: 9544:MZT1
uniprot id: A0A8J8XC33
uniprot id: G7NJF0
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9544:DAPK3
gene id: 9544:DAPK3
uniprot id: A0A8J8YA95
uniprot id: I0FPJ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:PDE10A
gene id: 9544:PDE10A
uniprot id: A0A1D5Q6B3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:NCSTN
gene id: 9544:NCSTN
uniprot id: F7EHX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9544:RFX1
gene id: 9544:RFX1
uniprot id: A0A5F7Z844
uniprot id: F6Y5S3
names: Subcellular Location Annotation
messages: Nucleus

9544:CCDC85B
gene id: 9544:CCDC85B
uniprot id: F7F848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9544:DYNLRB1
gene id: 9544:DYNLRB1
uniprot id: F7B1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9544:CPPED1
gene id: 9544:CPPED1
uniprot id: A0A5F7ZGQ4
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9544:TMSB15B
gene id: 9544:TMSB15B
uniprot id: A0A8J8YHD8
uniprot id: H9FTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:CACNA1E
gene id: 9544:CACNA1E
uniprot id: A0A1D5Q7C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.

9544:PTHLH
gene id: 9544:PTHLH
uniprot id: H9EU77
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9544:TMEM163
gene id: 9544:TMEM163
uniprot id: A0A5F7ZL78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

9544:CAPN6
gene id: 9544:CAPN6
uniprot id: A0A8J8YH84
uniprot id: G7NT58
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NEU1
gene id: 9544:NEU1
uniprot id: A0A8J8YRG4
uniprot id: F7EZS0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9544:CACNG7
gene id: 9544:CACNG7
uniprot id: A0A8J8YEP1
uniprot id: F7HNQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9544:CNOT3
gene id: 9544:CNOT3
uniprot id: H9FUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9544:PSENEN
gene id: 9544:PSENEN
uniprot id: A0A8J8XL39
uniprot id: F6PQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9544:FMO3
gene id: 9544:FMO3
uniprot id: F7HQX7
uniprot id: Q8SPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Liver.
messages: Microsome membrane

9544:FNTB
gene id: 9544:FNTB
uniprot id: H9EPW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9544:HS3ST1
gene id: 9544:HS3ST1
uniprot id: A0A8J8XSS7
uniprot id: F7DQN3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:TMEM200A
gene id: 9544:TMEM200A
uniprot id: A0A8J8XII1
uniprot id: F7GYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9544:SENP3
gene id: 9544:SENP3
uniprot id: F7HGI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9544:LYPLA1
gene id: 9544:LYPLA1
uniprot id: F6SPC5
uniprot id: F6Z819
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:BCLAF3
gene id: 9544:BCLAF3
uniprot id: A0A5F8AE95
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9544:AOC2
gene id: 9544:AOC2
uniprot id: F7GP69
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9544:SCAND1
gene id: 9544:SCAND1
uniprot id: G7N4Y2
names: Subcellular Location Annotation
messages: Nucleus

9544:LSM14B
gene id: 9544:LSM14B
uniprot id: A0A5F8AHK4
uniprot id: F7CDK2
names: Similarity
messages: Belongs to the LSM14 family.

9544:DDX53
gene id: 9544:DDX53
uniprot id: A0A5F7ZHZ6
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:TMCC2
gene id: 9544:TMCC2
uniprot id: A0A8J8YTC8
uniprot id: F7BGZ1
uniprot id: F7GNP4
names: Similarity
messages: Belongs to the TEX28 family.

9544:B3GNT7
gene id: 9544:B3GNT7
uniprot id: F7HQE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TMBIM1
gene id: 9544:TMBIM1
uniprot id: F6UPC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:PDK4
gene id: 9544:PDK4
uniprot id: A0A8J8XI95
uniprot id: F7FDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:SEPTIN6
gene id: 9544:SEPTIN6
uniprot id: A0A1D5R3V4
uniprot id: F6TJ87
uniprot id: H9FRS6
uniprot id: H9YXW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:GJA3
gene id: 9544:GJA3
uniprot id: A0A5F7ZEN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:PDCD10
gene id: 9544:PDCD10
uniprot id: H9FPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9544:MAST2
gene id: 9544:MAST2
uniprot id: A0A1D5QG69
uniprot id: F6S9N8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:STEAP3
gene id: 9544:STEAP3
uniprot id: A0A1D5R0G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9544:CMTM7
gene id: 9544:CMTM7
uniprot id: F6Y4H8
names: Subcellular Location Annotation
messages: Membrane

9544:HECTD1
gene id: 9544:HECTD1
uniprot id: A0A5F8AKA2
uniprot id: H9FSK0
uniprot id: H9FSK1
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9544:ZRANB1
gene id: 9544:ZRANB1
uniprot id: F7HTG6
uniprot id: H9FW56
names: Similarity
messages: Belongs to the peptidase C64 family.

9544:MYH2
gene id: 9544:MYH2
uniprot id: F6UHN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:TAS2R46
gene id: 9544:TAS2R46
uniprot id: Q645T4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
messages: cilium membrane

9544:RRAD
gene id: 9544:RRAD
uniprot id: A0A5F8AFL7
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9544:CDK5
gene id: 9544:CDK5
uniprot id: H9EQ04
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HBEGF
gene id: 9544:HBEGF
uniprot id: F7FK53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:P4HA1
gene id: 9544:P4HA1
uniprot id: A0A8J8Y6S5
uniprot id: G7N269
uniprot id: H9Z9F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9544:WDFY1
gene id: 9544:WDFY1
uniprot id: G7N920
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9544:NPAS4
gene id: 9544:NPAS4
uniprot id: F6XNH5
names: Subcellular Location Annotation
messages: Nucleus

9544:NUTF2
gene id: 9544:NUTF2
uniprot id: H9EQR2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9544:CFAP298
gene id: 9544:CFAP298
uniprot id: A0A1D5QDN3
uniprot id: A0A8J8Y0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9544:TUBA4A
gene id: 9544:TUBA4A
uniprot id: F6QRE8
uniprot id: F7B0U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9544:FOXN4
gene id: 9544:FOXN4
uniprot id: F6UGC7
names: Subcellular Location Annotation
messages: Nucleus

9544:BBS7
gene id: 9544:BBS7
uniprot id: H9EVY8
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9544:ALG12
gene id: 9544:ALG12
uniprot id: F6WHE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CCR5
gene id: 9544:CCR5
uniprot id: A0A5F8AE97
uniprot id: A0A8J8XUT3
uniprot id: P61813
uniprot id: Q09GT7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
messages: Palmitoylation in the C-terminal is important for cell surface expression.
messages: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).

9544:ZSCAN30
gene id: 9544:ZSCAN30
uniprot id: A0A5F7Z7C0
names: Subcellular Location Annotation
messages: Nucleus

9544:GJA1
gene id: 9544:GJA1
uniprot id: A0A8J8Y316
uniprot id: F7C314
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:SCRN1
gene id: 9544:SCRN1
uniprot id: A0A5F7ZWV4
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9544:ARFGEF2
gene id: 9544:ARFGEF2
uniprot id: F7AUW7
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9544:IL9
gene id: 9544:IL9
uniprot id: G7MUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9544:SF3A3
gene id: 9544:SF3A3
uniprot id: A0A8J8XEF9
uniprot id: G7MFY2
names: Similarity
messages: Belongs to the SF3A3 family.

9544:PTDSS1
gene id: 9544:PTDSS1
uniprot id: A0A8J8XBZ4
uniprot id: F6ZWH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:VAMP3
gene id: 9544:VAMP3
uniprot id: H9EV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9544:EIF2D
gene id: 9544:EIF2D
uniprot id: F7GX43
uniprot id: I0FIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9544:SGCG
gene id: 9544:SGCG
uniprot id: A0A5K1TU54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9544:NME7
gene id: 9544:NME7
uniprot id: H9FTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9544:ZC3H12B
gene id: 9544:ZC3H12B
uniprot id: F6UZL1
names: Similarity
messages: Belongs to the ZC3H12 family.

9544:GSTP1
gene id: 9544:GSTP1
uniprot id: H9Z845
uniprot id: Q28514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
messages: Cytoplasm
messages: Homodimer.
messages: Homodimer. Interacts with CDK5.
messages: Mitochondrion
messages: Nucleus

9544:GRIK1
gene id: 9544:GRIK1
uniprot id: F7AGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:EAF2
gene id: 9544:EAF2
uniprot id: F6QNE7
names: Similarity
messages: Belongs to the EAF family.

9544:GHRL
gene id: 9544:GHRL
uniprot id: Q6UDE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9544:MBOAT1
gene id: 9544:MBOAT1
uniprot id: F7HPV2
names: Subcellular Location Annotation
messages: Membrane

9544:ASMT
gene id: 9544:ASMT
uniprot id: Q8HZJ0
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
messages: Highly expressed in pineal gland. In the retina, 10- to 100-fold lower expression compared to pineal gland, if any.
messages: Homodimer.
messages: No night/day variations.

9544:FKRP
gene id: 9544:FKRP
uniprot id: F6Z946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9544:PAN2
gene id: 9544:PAN2
uniprot id: I0FWV6
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9544:PFDN5
gene id: 9544:PFDN5
uniprot id: F7HTC8
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9544:ARL2BP
gene id: 9544:ARL2BP
uniprot id: A0A5F7ZVI3
uniprot id: A0A8J8YBL3
uniprot id: F6W9G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9544:ATP5PF
gene id: 9544:ATP5PF
uniprot id: A0A1D5QZG5
uniprot id: A0A8J8XL47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9544:PRKCH
gene id: 9544:PRKCH
uniprot id: F7BUZ8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9544:KRTCAP2
gene id: 9544:KRTCAP2
uniprot id: A0A8J8YST1
uniprot id: F7HTS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9544:TMEM123
gene id: 9544:TMEM123
uniprot id: H9FPK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9544:SKAP1
gene id: 9544:SKAP1
uniprot id: A0A5F8AE80
uniprot id: A0A8J8YJN6
uniprot id: G7NHC4
names: Similarity
messages: Belongs to the SKAP family.

9544:IMMP1L
gene id: 9544:IMMP1L
uniprot id: F7CYD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9544:ENO2
gene id: 9544:ENO2
uniprot id: A0A8J8YD48
uniprot id: F6X1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:BMP2
gene id: 9544:BMP2
uniprot id: A0A8J8YQ20
uniprot id: G7N2Y0
names: Similarity
messages: Belongs to the TGF-beta family.

9544:PPARGC1A
gene id: 9544:PPARGC1A
uniprot id: G7MSN5
names: Subcellular Location Annotation
messages: PML body

9544:ADD2
gene id: 9544:ADD2
uniprot id: A0A8J8XAA6
uniprot id: F7CGX1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9544:CCDC86
gene id: 9544:CCDC86
uniprot id: A0A8J8YTC6
uniprot id: G7ND32
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC4A3
gene id: 9544:SLC4A3
uniprot id: I2CV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9544:OTOP2
gene id: 9544:OTOP2
uniprot id: G7NGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9544:ASPA
gene id: 9544:ASPA
uniprot id: A0A5F8AA29
uniprot id: A0A8J8XKZ7
uniprot id: F7DR53
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9544:BCO1
gene id: 9544:BCO1
uniprot id: A0A8J8YEV4
uniprot id: G7NR55
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9544:MRPL42
gene id: 9544:MRPL42
uniprot id: A0A8J8YJL8
uniprot id: G7N7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9544:MMP8
gene id: 9544:MMP8
uniprot id: A0A5F8A8W4
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:SIGMAR1
gene id: 9544:SIGMAR1
uniprot id: A0A8J8YNH2
uniprot id: F7HC83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9544:MLLT11
gene id: 9544:MLLT11
uniprot id: A0A8J8YPB8
uniprot id: H9EVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9544:SFT2D2
gene id: 9544:SFT2D2
uniprot id: F7H6K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9544:IPO8
gene id: 9544:IPO8
uniprot id: A0A1D5Q2J2
uniprot id: A0A8J8YGE8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:HMX2
gene id: 9544:HMX2
uniprot id: A0A8J8XP13
uniprot id: F7DSC8
names: Subcellular Location Annotation
messages: Nucleus

9544:MIS12
gene id: 9544:MIS12
uniprot id: H9YZK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9544:FOXP2
gene id: 9544:FOXP2
uniprot id: A0A1I7Q461
uniprot id: Q8MJ97
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).

9544:TBCCD1
gene id: 9544:TBCCD1
uniprot id: F6WSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9544:CX3CR1
gene id: 9544:CX3CR1
uniprot id: H9EX48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9544:LTK
gene id: 9544:LTK
uniprot id: F7HBY2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

9544:BBS5
gene id: 9544:BBS5
uniprot id: A0A5F8A0K9
uniprot id: H9Z224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9544:CRYGA
gene id: 9544:CRYGA
uniprot id: A7KK27
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:MAMU-DRA
gene id: 9544:MAMU-DRA
uniprot id: A0A8J8XEP6
uniprot id: Q6EWK7
uniprot id: Q6EWK9
uniprot id: Q6EWL5
names: Similarity
messages: Belongs to the MHC class II family.

9544:SNX18
gene id: 9544:SNX18
uniprot id: I2CUY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9544:LRRC8C
gene id: 9544:LRRC8C
uniprot id: A0A8J8XE06
uniprot id: F7HLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:RHO
gene id: 9544:RHO
uniprot id: A0A8J8YFX4
uniprot id: F7ETG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9544:LRRC8D
gene id: 9544:LRRC8D
uniprot id: A0A8J8XNZ6
uniprot id: F6TCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:DPM3
gene id: 9544:DPM3
uniprot id: F6R3K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9544:CAMK2N2
gene id: 9544:CAMK2N2
uniprot id: F6YD54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9544:UBP1
gene id: 9544:UBP1
uniprot id: A0A8J8YS88
uniprot id: F7CJ26
uniprot id: F7GGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9544:MYH9
gene id: 9544:MYH9
uniprot id: A0A1D5R5P8
uniprot id: F7B7D7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:SNRPA
gene id: 9544:SNRPA
uniprot id: A0A1D5Q8H4
uniprot id: A0A8J8YH87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9544:SEMA6D
gene id: 9544:SEMA6D
uniprot id: F7GXZ9
uniprot id: I2CTC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ZC3HC1
gene id: 9544:ZC3HC1
uniprot id: F6PNL5
names: Subcellular Location Annotation
messages: Nucleus

9544:RAD1
gene id: 9544:RAD1
uniprot id: F7A5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9544:SCN4A
gene id: 9544:SCN4A
uniprot id: F6ZQ36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:CLDN1
gene id: 9544:CLDN1
uniprot id: A0A8J8XPK1
uniprot id: F6TZW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:LCK
gene id: 9544:LCK
uniprot id: A0A1D5Q9I1
uniprot id: G7MI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:PTTG1
gene id: 9544:PTTG1
uniprot id: F6UYK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9544:DYNC1LI2
gene id: 9544:DYNC1LI2
uniprot id: A0A1D5RCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9544:TAMM41
gene id: 9544:TAMM41
uniprot id: G7MKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9544:PFN1
gene id: 9544:PFN1
uniprot id: F7H2A5
names: Similarity
messages: Belongs to the profilin family.

9544:NKAP
gene id: 9544:NKAP
uniprot id: H9ZDI2
names: Similarity
messages: Belongs to the NKAP family.

9544:LMX1A
gene id: 9544:LMX1A
uniprot id: A0A8J8XGP5
uniprot id: F7B132
names: Subcellular Location Annotation
messages: Nucleus

9544:AASS
gene id: 9544:AASS
uniprot id: G7MM77
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9544:NOTCH2
gene id: 9544:NOTCH2
uniprot id: H9YZ83
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9544:FGF4
gene id: 9544:FGF4
uniprot id: A0A7U3JW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9544:PEX13
gene id: 9544:PEX13
uniprot id: A0A8J8YRF9
uniprot id: H9ER79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

9544:GALNTL5
gene id: 9544:GALNTL5
uniprot id: F7F8Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9544:COPS7A
gene id: 9544:COPS7A
uniprot id: A0A8J8Y7B9
uniprot id: F6X4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9544:PDIA4
gene id: 9544:PDIA4
uniprot id: H9G279
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9544:CCN3
gene id: 9544:CCN3
uniprot id: A0A8J8Y4E9
uniprot id: F6WCM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:RPLP1
gene id: 9544:RPLP1
uniprot id: A0A8J8YGC0
uniprot id: F6TQ53
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9544:TES
gene id: 9544:TES
uniprot id: F7ERF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

9544:CKLF
gene id: 9544:CKLF
uniprot id: A0A8J8XHB7
uniprot id: F7HRM2
uniprot id: H9YWT0
names: Subcellular Location Annotation
messages: Membrane

9544:PIF1
gene id: 9544:PIF1
uniprot id: A0A1D5Q3I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9544:ECHS1
gene id: 9544:ECHS1
uniprot id: A0A5F7ZWH5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9544:EXOSC5
gene id: 9544:EXOSC5
uniprot id: F7CTF5
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ARHGDIA
gene id: 9544:ARHGDIA
uniprot id: F6VTL8
names: Similarity
messages: Belongs to the Rho GDI family.

9544:MRI1
gene id: 9544:MRI1
uniprot id: A0A8J8Y6Q1
uniprot id: G7NLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9544:SDHAF2
gene id: 9544:SDHAF2
uniprot id: A0A8J8Y5Q8
uniprot id: F7DUG5
uniprot id: H9Z2F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9544:FLAD1
gene id: 9544:FLAD1
uniprot id: G7MDV3
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9544:MAOB
gene id: 9544:MAOB
uniprot id: A0A5F7ZM05
uniprot id: A0A5K1VFS4
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9544:ADI1
gene id: 9544:ADI1
uniprot id: F6QS54
uniprot id: H9FWN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9544:ZDHHC16
gene id: 9544:ZDHHC16
uniprot id: A0A8J8Y966
uniprot id: F7GGL0
uniprot id: F7GGL9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:ARSG
gene id: 9544:ARSG
uniprot id: A0A5F7ZR14
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:IMP4
gene id: 9544:IMP4
uniprot id: A0A8J8Y7R3
uniprot id: F6ZZ93
names: Subcellular Location Annotation
messages: nucleolus

9544:SAG
gene id: 9544:SAG
uniprot id: F7E8B5
names: Similarity
messages: Belongs to the arrestin family.

9544:TNPO2
gene id: 9544:TNPO2
uniprot id: A0A8J8YHM1
uniprot id: F6YXG7
uniprot id: F6YXH7
names: Subcellular Location Annotation
messages: Cytoplasm

9544:SLC26A7
gene id: 9544:SLC26A7
uniprot id: F7D455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9544:BTBD10
gene id: 9544:BTBD10
uniprot id: A0A5F8AH43
uniprot id: A0A8J8Y6J4
uniprot id: F6Y3M8
uniprot id: I0FVN1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:EIF2B2
gene id: 9544:EIF2B2
uniprot id: A0A8J8Y3L2
uniprot id: F7HB02
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9544:KCNJ1
gene id: 9544:KCNJ1
uniprot id: A0A1D5QD24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:C11H12orf57
gene id: 9544:C11H12orf57
uniprot id: A0A8J8YD07
uniprot id: F6SIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9544:NPNT
gene id: 9544:NPNT
uniprot id: F7F563
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DPYSL3
gene id: 9544:DPYSL3
uniprot id: A0A1D5R2B7
uniprot id: A0A8J8XZM9
uniprot id: I2CY64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

9544:CPNE5
gene id: 9544:CPNE5
uniprot id: A0A8J8YJJ0
uniprot id: F6TSZ3
uniprot id: G7MP62
names: Similarity
messages: Belongs to the copine family.

9544:VRK1
gene id: 9544:VRK1
uniprot id: H9ZD73
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:F10
gene id: 9544:F10
uniprot id: A0N065
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:P4HA2
gene id: 9544:P4HA2
uniprot id: A0A8J8XWD2
uniprot id: H9ZEY7
uniprot id: I0FFW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9544:HMGN1
gene id: 9544:HMGN1
uniprot id: A0A1D5RJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:TMEM225
gene id: 9544:TMEM225
uniprot id: A0A8J8XPK7
uniprot id: F6Y415
names: Subcellular Location Annotation
messages: Membrane

9544:NAMPT
gene id: 9544:NAMPT
uniprot id: H9EW35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9544:WDR18
gene id: 9544:WDR18
uniprot id: H9EQY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
messages: nucleolus
messages: nucleoplasm

9544:NCAPH2
gene id: 9544:NCAPH2
uniprot id: A0A1D5Q3Y6
uniprot id: H9Z858
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

9544:RNF114
gene id: 9544:RNF114
uniprot id: F6RK58
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9544:RBM42
gene id: 9544:RBM42
uniprot id: A0A8J8XNZ5
uniprot id: F6YCY8
uniprot id: F6YD35
names: Similarity
messages: Belongs to the RRM RBM42 family.

9544:MST1
gene id: 9544:MST1
uniprot id: A0A5F7ZVA6
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:BAG6
gene id: 9544:BAG6
uniprot id: H9ESC5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9544:CAPN11
gene id: 9544:CAPN11
uniprot id: A0A1D5R371
uniprot id: F6SFW8
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:CD63
gene id: 9544:CD63
uniprot id: A0A8J8Y1E7
uniprot id: F6XET9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9544:BCCIP
gene id: 9544:BCCIP
uniprot id: A0A5F8AJV9
uniprot id: F6UR60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9544:KIAA2013
gene id: 9544:KIAA2013
uniprot id: I2CUT2
names: Subcellular Location Annotation
messages: Membrane

9544:VTA1
gene id: 9544:VTA1
uniprot id: F6TI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9544:LOC696959
gene id: 9544:LOC696959
uniprot id: F7CUY7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9544:MFNG
gene id: 9544:MFNG
uniprot id: A0A1D5QYG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MAP2K6
gene id: 9544:MAP2K6
uniprot id: H9EP89
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HTR7
gene id: 9544:HTR7
uniprot id: A0A5F7Z9S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:IRF2BP1
gene id: 9544:IRF2BP1
uniprot id: F7CH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9544:LOC699317
gene id: 9544:LOC699317
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SPACA3
gene id: 9544:SPACA3
uniprot id: A0A080YV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

9544:TASP1
gene id: 9544:TASP1
uniprot id: A0A8J8XLE2
uniprot id: G7N2Z7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9544:JPH1
gene id: 9544:JPH1
uniprot id: A0A5F8AK43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9544:OR10G2
gene id: 9544:OR10G2
uniprot id: F7H0B8
names: Subcellular Location Annotation
messages: Membrane

9544:GJA9
gene id: 9544:GJA9
uniprot id: F6QYD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:LOC106992372
gene id: 9544:LOC106992372
uniprot id: A0A5F8AUD7
names: Subcellular Location Annotation
messages: Membrane

9544:C1D
gene id: 9544:C1D
uniprot id: F7HGG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9544:FGFR1
gene id: 9544:FGFR1
uniprot id: A0A1D5Q279
uniprot id: F7A4R9
uniprot id: G7MZ50
uniprot id: H9FRD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9544:STAMBPL1
gene id: 9544:STAMBPL1
uniprot id: F7EC45
names: Similarity
messages: Belongs to the peptidase M67C family.

9544:UNC119
gene id: 9544:UNC119
uniprot id: H9EWD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9544:FOXN3
gene id: 9544:FOXN3
uniprot id: H9FP99
uniprot id: H9Z4S3
names: Subcellular Location Annotation
messages: Nucleus

9544:CRYGC
gene id: 9544:CRYGC
uniprot id: A3RLD8
uniprot id: G7N8S3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9544:PBX4
gene id: 9544:PBX4
uniprot id: A0A1D5R3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:VTI1A
gene id: 9544:VTI1A
uniprot id: A0A8J8XZG7
uniprot id: G7N154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9544:GRAP
gene id: 9544:GRAP
uniprot id: F7GJG7
uniprot id: G8F170
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9544:ALG11
gene id: 9544:ALG11
uniprot id: H9FUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9544:SMDT1
gene id: 9544:SMDT1
uniprot id: A0A8J8XZ34
uniprot id: F7H5N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9544:LY6D
gene id: 9544:LY6D
uniprot id: G7N076
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:MMP1
gene id: 9544:MMP1
uniprot id: F6WYF2
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:TM2D2
gene id: 9544:TM2D2
uniprot id: A0A8J8XY28
uniprot id: F6WJ17
names: Subcellular Location Annotation
messages: Membrane

9544:TRMT61A
gene id: 9544:TRMT61A
uniprot id: F7D5Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9544:TDGF1
gene id: 9544:TDGF1
uniprot id: A0A5F8AHE6
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NOS3
gene id: 9544:NOS3
uniprot id: F6WEB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9544:COX7A2L
gene id: 9544:COX7A2L
uniprot id: A0A8J8XJG7
uniprot id: F7GAF4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9544:ERGIC3
gene id: 9544:ERGIC3
uniprot id: A0A5K1TWI8
uniprot id: H9EQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9544:TALDO1
gene id: 9544:TALDO1
uniprot id: H9FZ06
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9544:LOC718407
gene id: 9544:LOC718407
uniprot id: A0A8J8Y6N6
uniprot id: G7NIJ1
names: Similarity
messages: Belongs to the SUI1 family.

9544:FIP1L1
gene id: 9544:FIP1L1
uniprot id: A0A8J8XYB2
uniprot id: F7HS19
uniprot id: F7HS24
uniprot id: H9EN31
uniprot id: H9G090
uniprot id: H9YUP2
uniprot id: H9ZE01
uniprot id: H9ZE03
uniprot id: I0FVD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9544:COG7
gene id: 9544:COG7
uniprot id: F7A3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SLC35C2
gene id: 9544:SLC35C2
uniprot id: A0A8J8Y7B8
uniprot id: G7N4M3
uniprot id: H9YZE6
names: Subcellular Location Annotation
messages: Membrane

9544:CASK
gene id: 9544:CASK
uniprot id: A0A1D5QVF6
uniprot id: A0A1D5R5P2
uniprot id: H9EPC3
names: Similarity
messages: Belongs to the MAGUK family.

9544:OR6C4
gene id: 9544:OR6C4
uniprot id: F6S5B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PSMD6
gene id: 9544:PSMD6
uniprot id: A0A8J8YND6
uniprot id: F7H0I6
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

9544:POMT2
gene id: 9544:POMT2
uniprot id: H9EVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9544:BAK1
gene id: 9544:BAK1
uniprot id: H9H3A9
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:HDDC2
gene id: 9544:HDDC2
uniprot id: A0A8J8YN83
uniprot id: H9Z9I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9544:DBX1
gene id: 9544:DBX1
uniprot id: A0A1D5Q6V9
names: Subcellular Location Annotation
messages: Nucleus

9544:REM1
gene id: 9544:REM1
uniprot id: A0A8J8Y8S0
uniprot id: G7N556
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9544:IRF4
gene id: 9544:IRF4
uniprot id: F7A8U1
uniprot id: H9Z8N1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:LOC702299
gene id: 9544:LOC702299
uniprot id: F6U6R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9544:PSMC1
gene id: 9544:PSMC1
uniprot id: I0FTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9544:DAZAP2
gene id: 9544:DAZAP2
uniprot id: A0A1D5QD71
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9544:BOK
gene id: 9544:BOK
uniprot id: F6VX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9544:LHX8
gene id: 9544:LHX8
uniprot id: F7BHJ9
names: Subcellular Location Annotation
messages: Nucleus

9544:PDHX
gene id: 9544:PDHX
uniprot id: G7NDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9544:PNLIP
gene id: 9544:PNLIP
uniprot id: G7N172
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9544:CDC25C
gene id: 9544:CDC25C
uniprot id: F7FH10
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9544:SCAMP1
gene id: 9544:SCAMP1
uniprot id: A0A8J8XWV4
uniprot id: G7MUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:PTGS1
gene id: 9544:PTGS1
uniprot id: F6S984
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DCP2
gene id: 9544:DCP2
uniprot id: A0A8J8YEL4
uniprot id: F7CI46
uniprot id: G7MVJ6
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9544:VPS33A
gene id: 9544:VPS33A
uniprot id: F7HG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9544:SYNDIG1L
gene id: 9544:SYNDIG1L
uniprot id: A0A8J8YR75
uniprot id: G7MYT0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:PLPP3
gene id: 9544:PLPP3
uniprot id: H9G166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:TAF1B
gene id: 9544:TAF1B
uniprot id: F7G949
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9544:NSUN5
gene id: 9544:NSUN5
uniprot id: F7G8Y6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9544:GALNT18
gene id: 9544:GALNT18
uniprot id: A0A8J8YHR2
uniprot id: G7NDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:FGF19
gene id: 9544:FGF19
uniprot id: A0A5F8AV87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:PFDN2
gene id: 9544:PFDN2
uniprot id: A0A8J8XNV2
uniprot id: F6V169
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9544:MPC2
gene id: 9544:MPC2
uniprot id: A0A8J8XB84
uniprot id: G7MF91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9544:TIMP4
gene id: 9544:TIMP4
uniprot id: F6T9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9544:S1PR1
gene id: 9544:S1PR1
uniprot id: H9EUW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TMEM165
gene id: 9544:TMEM165
uniprot id: A0A1D5RDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

9544:GPNMB
gene id: 9544:GPNMB
uniprot id: A0A5F7ZWL3
uniprot id: A0A5K1U951
names: Similarity
messages: Belongs to the PMEL/NMB family.

9544:ALPL
gene id: 9544:ALPL
uniprot id: A0A1D5R5B1
uniprot id: A0A8J8Y875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9544:PDS5B
gene id: 9544:PDS5B
uniprot id: A0A5F8AJT7
uniprot id: F7EQ66
uniprot id: H9Z6N2
names: Similarity
messages: Belongs to the PDS5 family.

9544:NDUFS1
gene id: 9544:NDUFS1
uniprot id: F7CZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9544:DNASE2B
gene id: 9544:DNASE2B
uniprot id: F6X4X0
uniprot id: G8F191
names: Similarity
messages: Belongs to the DNase II family.

9544:ODAM
gene id: 9544:ODAM
uniprot id: A1YQ92
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: O-glycosylated.
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9544:TMEM91
gene id: 9544:TMEM91
uniprot id: F6Z1E1
uniprot id: H9EQY1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:CFAP206
gene id: 9544:CFAP206
uniprot id: G7MPV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

9544:ITGA8
gene id: 9544:ITGA8
uniprot id: A0A5F8AHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:MYO1B
gene id: 9544:MYO1B
uniprot id: A0A8J8YRP1
uniprot id: F7AJ10
uniprot id: F7AJ56
uniprot id: G7N8J0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:TSSK2
gene id: 9544:TSSK2
uniprot id: F7H4I7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:VPS36
gene id: 9544:VPS36
uniprot id: H9FV58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9544:TOMM40L
gene id: 9544:TOMM40L
uniprot id: A0A8J8YRF6
uniprot id: F7FCD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:LOC106997918
gene id: 9544:LOC106997918
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:CD44
gene id: 9544:CD44
uniprot id: A0A1D5QRB0
uniprot id: A0A8J8XS81
uniprot id: F6ZDZ8
uniprot id: H9Z063
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9544:PDCD5
gene id: 9544:PDCD5
uniprot id: F6S8R2
names: Similarity
messages: Belongs to the PDCD5 family.

9544:PPP2R5D
gene id: 9544:PPP2R5D
uniprot id: H9FWP2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:GIMAP5
gene id: 9544:GIMAP5
uniprot id: F7HGI6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9544:AQP9
gene id: 9544:AQP9
uniprot id: A0A8J8XHM0
uniprot id: F6WY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:PLG
gene id: 9544:PLG
uniprot id: P12545
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, resulting in 2 chains held together by 2 disulfide bonds. Without the inhibitor, the activation involves also removal of the activation peptide.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity).
messages: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.
messages: Kringle domains mediate interaction with CSPG4.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
messages: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
messages: Secreted

9544:GRIN2B
gene id: 9544:GRIN2B
uniprot id: A0A8J8Y2N3
uniprot id: F6T8S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:LHPP
gene id: 9544:LHPP
uniprot id: A0A1D5QVA2
uniprot id: F7ERE1
uniprot id: H9EW11
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:MEGF8
gene id: 9544:MEGF8
uniprot id: A0A1D5Q5S1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:AAR2
gene id: 9544:AAR2
uniprot id: H9EUV9
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9544:MAP3K10
gene id: 9544:MAP3K10
uniprot id: F6XQC8
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9544:EHHADH
gene id: 9544:EHHADH
uniprot id: F7GFA8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9544:TNFRSF19
gene id: 9544:TNFRSF19
uniprot id: F6YX32
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CHSY1
gene id: 9544:CHSY1
uniprot id: F7H7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:EIF1AD
gene id: 9544:EIF1AD
uniprot id: A0A8J8YLM2
uniprot id: F6T7W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9544:GSTA4
gene id: 9544:GSTA4
uniprot id: A0A1D5QV65
uniprot id: A0A8J8XRE3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:PAMR1
gene id: 9544:PAMR1
uniprot id: F6ZDE4
uniprot id: G7NDK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLA
gene id: 9544:SLA
uniprot id: F6SJ90
names: Subcellular Location Annotation
messages: Cytoplasm

9544:CSH4
gene id: 9544:CSH4
uniprot id: Q1L7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9544:MAT2B
gene id: 9544:MAT2B
uniprot id: F6RZ93
uniprot id: F6RZA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9544:LOC704341
gene id: 9544:LOC704341
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:LOC694543
gene id: 9544:LOC694543
uniprot id: F7DPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PSMD8
gene id: 9544:PSMD8
uniprot id: I2CYQ9
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9544:LOC706691
gene id: 9544:LOC706691
uniprot id: A0A5F8A720
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:GRP
gene id: 9544:GRP
uniprot id: F6SRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

9544:PEBP1
gene id: 9544:PEBP1
uniprot id: F5CI18
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9544:KHDC4
gene id: 9544:KHDC4
uniprot id: H9Z6I1
names: Similarity
messages: Belongs to the KHDC4 family.

9544:CBX1
gene id: 9544:CBX1
uniprot id: A0A5F7ZEG7
uniprot id: H9EPB7
names: Subcellular Location Annotation
messages: Nucleus

9544:PIPOX
gene id: 9544:PIPOX
uniprot id: A0A8J8XTA3
uniprot id: F6XXQ3
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9544:HNF4G
gene id: 9544:HNF4G
uniprot id: A0A5F8ALS9
uniprot id: F7H2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:SLC41A3
gene id: 9544:SLC41A3
uniprot id: A0A8J8Y4U5
uniprot id: F7H8V4
uniprot id: F7H8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9544:POLR1C
gene id: 9544:POLR1C
uniprot id: A0A8J8Y886
uniprot id: G7MPF0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9544:WLS
gene id: 9544:WLS
uniprot id: H9G004
uniprot id: H9G005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9544:UBE2G2
gene id: 9544:UBE2G2
uniprot id: A0A8J8XIL5
uniprot id: F7HD05
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:PPP1R14D
gene id: 9544:PPP1R14D
uniprot id: F7GNA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9544:LOC696506
gene id: 9544:LOC696506
uniprot id: A0A1D5RH28
uniprot id: A0A8J8XC48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TRUB1
gene id: 9544:TRUB1
uniprot id: H9FQ80
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9544:SDC4
gene id: 9544:SDC4
uniprot id: A0A8J8XB75
uniprot id: I0FGX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9544:DYNC2H1
gene id: 9544:DYNC2H1
uniprot id: F7GFI1
uniprot id: F7HHK5
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:HABP4
gene id: 9544:HABP4
uniprot id: I2CUL7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CHST6
gene id: 9544:CHST6
uniprot id: F6S4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:CAMK2N1
gene id: 9544:CAMK2N1
uniprot id: F7HAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9544:ELF1
gene id: 9544:ELF1
uniprot id: A0A8J8XLF5
uniprot id: F7B6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:LOC703853
gene id: 9544:LOC703853
uniprot id: F7HR63
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9544:PQLC3
gene id: 9544:PQLC3
uniprot id: G7NBA7
names: Subcellular Location Annotation
messages: Membrane

9544:TMEM177
gene id: 9544:TMEM177
uniprot id: A0A5F8AFC3
uniprot id: G8F1U2
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9544:SLC17A7
gene id: 9544:SLC17A7
uniprot id: F6W612
names: Subcellular Location Annotation
messages: Membrane

9544:CBX6
gene id: 9544:CBX6
uniprot id: A0A1D5QQQ4
names: Subcellular Location Annotation
messages: Nucleus

9544:LHX9
gene id: 9544:LHX9
uniprot id: A0A8J8Y9E1
uniprot id: F6V031
names: Subcellular Location Annotation
messages: Nucleus

9544:DPH3
gene id: 9544:DPH3
uniprot id: F7GSP4
uniprot id: I0FR09
names: Similarity
messages: Belongs to the DPH3 family.

9544:KCNJ10
gene id: 9544:KCNJ10
uniprot id: A0A8J8Y8V6
uniprot id: F6V197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:PAPOLG
gene id: 9544:PAPOLG
uniprot id: A0A5K1TWB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9544:SCAMP2
gene id: 9544:SCAMP2
uniprot id: H9FND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:AP1G1
gene id: 9544:AP1G1
uniprot id: H9EPI6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9544:CDKL1
gene id: 9544:CDKL1
uniprot id: F7H9C7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:PKIB
gene id: 9544:PKIB
uniprot id: H9FWZ0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9544:PLBD2
gene id: 9544:PLBD2
uniprot id: I2CYI6
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9544:KCNMA1
gene id: 9544:KCNMA1
uniprot id: O18867
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9544:SRRT
gene id: 9544:SRRT
uniprot id: A0A8J8XBI4
uniprot id: G7MNW1
uniprot id: H9EPK5
uniprot id: I2CUE8
names: Similarity
messages: Belongs to the ARS2 family.

9544:OPA1
gene id: 9544:OPA1
uniprot id: F6Y1R3
uniprot id: I2CT67
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9544:PSMB4
gene id: 9544:PSMB4
uniprot id: A0A8J8XEB4
uniprot id: F7H4P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9544:DPP7
gene id: 9544:DPP7
uniprot id: H9EXB4
names: Similarity
messages: Belongs to the peptidase S28 family.

9544:CLIC5
gene id: 9544:CLIC5
uniprot id: A0A5F7ZB41
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9544:CEBPE
gene id: 9544:CEBPE
uniprot id: A0A8J8XML6
uniprot id: F7CV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9544:RPL13
gene id: 9544:RPL13
uniprot id: F7ES75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9544:C9H10orf53
gene id: 9544:C9H10orf53
uniprot id: A0A1D5RK91
names: Similarity
messages: Belongs to the UPF0728 family.

9544:MPV17
gene id: 9544:MPV17
uniprot id: H9Z951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9544:TMLHE
gene id: 9544:TMLHE
uniprot id: A0A8J8YF36
uniprot id: G7NSZ0
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9544:ESRRA
gene id: 9544:ESRRA
uniprot id: A0A5F8A206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9544:SLC14A1
gene id: 9544:SLC14A1
uniprot id: A0A1D5QMW3
uniprot id: F7GPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9544:NIPSNAP3B
gene id: 9544:NIPSNAP3B
uniprot id: A0A1D5QMY7
names: Similarity
messages: Belongs to the NipSnap family.

9544:ATAD1
gene id: 9544:ATAD1
uniprot id: A0A1D5R0U6
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:PAM
gene id: 9544:PAM
uniprot id: I0FS58
uniprot id: I2CX43
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9544:AGAP2
gene id: 9544:AGAP2
uniprot id: I2CTW2
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9544:NANOS2
gene id: 9544:NANOS2
uniprot id: A0A8J8XZ14
uniprot id: F7HIW0
names: Similarity
messages: Belongs to the nanos family.

9544:MED30
gene id: 9544:MED30
uniprot id: A0A1D5R5X4
uniprot id: A0A8J8XZX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9544:TMEM167B
gene id: 9544:TMEM167B
uniprot id: H9EQ41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PICK1
gene id: 9544:PICK1
uniprot id: H9G232
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9544:ATP23
gene id: 9544:ATP23
uniprot id: A0A8J8YBJ3
uniprot id: G7N7I2
names: Similarity
messages: Belongs to the peptidase M76 family.

9544:RUVBL2
gene id: 9544:RUVBL2
uniprot id: F6ZUY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9544:CHMP1B
gene id: 9544:CHMP1B
uniprot id: H9EQ92
names: Similarity
messages: Belongs to the SNF7 family.

9544:TNFRSF4
gene id: 9544:TNFRSF4
uniprot id: A0A5F7ZEC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ELOVL5
gene id: 9544:ELOVL5
uniprot id: A0A5F7ZSW0
uniprot id: H9FY41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

9544:SLC2A2
gene id: 9544:SLC2A2
uniprot id: F6U5N3
uniprot id: F7CLP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9544:STX7
gene id: 9544:STX7
uniprot id: A0A8J8YHK2
uniprot id: F7ATP9
names: Similarity
messages: Belongs to the syntaxin family.

9544:GCH1
gene id: 9544:GCH1
uniprot id: F6ZD19
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9544:MKS1
gene id: 9544:MKS1
uniprot id: G7NHR8
names: Subcellular Location Annotation
messages: cilium basal body

9544:PIP4P2
gene id: 9544:PIP4P2
uniprot id: A0A8J8YLE6
uniprot id: F7AAJ6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9544:NBR1
gene id: 9544:NBR1
uniprot id: A0A5F7ZD70
uniprot id: A0A5F8ACS9
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9544:SPTLC2
gene id: 9544:SPTLC2
uniprot id: A0A1D5Q2N7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9544:FAM131A
gene id: 9544:FAM131A
uniprot id: A0A8J8YD05
uniprot id: G7MJ52
names: Similarity
messages: Belongs to the FAM131 family.

9544:RGMA
gene id: 9544:RGMA
uniprot id: A0A8J8Y4A6
uniprot id: F7FQ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9544:ACP5
gene id: 9544:ACP5
uniprot id: F7GXT7
names: Cofactor
messages: Binds 2 iron ions per subunit.

9544:KCTD13
gene id: 9544:KCTD13
uniprot id: A0A8J8YHD1
uniprot id: G7NQI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9544:UBE2C
gene id: 9544:UBE2C
uniprot id: F7HGB1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:SLC26A10
gene id: 9544:SLC26A10
uniprot id: A0A5F7ZPD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:RNFT1
gene id: 9544:RNFT1
uniprot id: A0A5F7ZLC1
names: Subcellular Location Annotation
messages: Membrane

9544:CX3CL1
gene id: 9544:CX3CL1
uniprot id: Q8HXZ1
names: Subcellular Location Annotation
messages: Secreted

9544:GTF2F1
gene id: 9544:GTF2F1
uniprot id: A0A1D5R7P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

9544:LTB4R
gene id: 9544:LTB4R
uniprot id: G7MXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:POLG
gene id: 9544:POLG
uniprot id: F6VGG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9544:RTN4IP1
gene id: 9544:RTN4IP1
uniprot id: A0A8J8YF21
uniprot id: G7MQ06
uniprot id: I2CTU3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9544:RC3H2
gene id: 9544:RC3H2
uniprot id: A0A1D5REV0
uniprot id: F7HDA8
names: Subcellular Location Annotation
messages: P-body

9544:RAX2
gene id: 9544:RAX2
uniprot id: A0A8J8XMX4
uniprot id: F6YCG6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CRX.
messages: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
messages: Nucleus

9544:EDN2
gene id: 9544:EDN2
uniprot id: G7MGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9544:TRPC3
gene id: 9544:TRPC3
uniprot id: A0A1D5R929
uniprot id: F7H6Q8
names: Subcellular Location Annotation
messages: Membrane

9544:FAM234B
gene id: 9544:FAM234B
uniprot id: A0A1D5QML4
names: Similarity
messages: Belongs to the FAM234 family.

9544:CALHM5
gene id: 9544:CALHM5
uniprot id: G7MQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9544:TNMD
gene id: 9544:TNMD
uniprot id: F7HUK2
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9544:HMGA1
gene id: 9544:HMGA1
uniprot id: H9Z8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9544:FAM3C
gene id: 9544:FAM3C
uniprot id: A0A5K1U705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9544:KRT8
gene id: 9544:KRT8
uniprot id: F6U9A3
names: Similarity
messages: Belongs to the intermediate filament family.

9544:RPL41
gene id: 9544:RPL41
uniprot id: H9EP86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.
messages: Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

9544:CBX8
gene id: 9544:CBX8
uniprot id: H9ZBK9
names: Subcellular Location Annotation
messages: Nucleus

9544:LDLRAD4
gene id: 9544:LDLRAD4
uniprot id: H9YY95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:POLR2G
gene id: 9544:POLR2G
uniprot id: A0A1D5R0T0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9544:FABP12
gene id: 9544:FABP12
uniprot id: A0A8J8Y013
uniprot id: F6PWH6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:LOC719964
gene id: 9544:LOC719964
uniprot id: A0A5F8A2H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PCYT2
gene id: 9544:PCYT2
uniprot id: I0FTU5
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9544:FAM83B
gene id: 9544:FAM83B
uniprot id: F6Q2E7
names: Similarity
messages: Belongs to the FAM83 family.

9544:PTP4A2
gene id: 9544:PTP4A2
uniprot id: H9EN41
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9544:CCL8
gene id: 9544:CCL8
uniprot id: Q8HYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:FAM118B
gene id: 9544:FAM118B
uniprot id: A0A5F8A7R4
uniprot id: F7HSX4
uniprot id: I0FGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9544:NUMB
gene id: 9544:NUMB
uniprot id: G7MYL6
uniprot id: H9ETQ5
uniprot id: H9ETT6
uniprot id: H9ZER2
uniprot id: H9ZER3
uniprot id: I0FVZ9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9544:ALG8
gene id: 9544:ALG8
uniprot id: H9EVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LOC717598
gene id: 9544:LOC717598
uniprot id: A0A8J8XYP4
uniprot id: F6TP71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ARL6IP5
gene id: 9544:ARL6IP5
uniprot id: A0A8J8XX32
uniprot id: F7FCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9544:FARS2
gene id: 9544:FARS2
uniprot id: H9EXA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9544:PYCR2
gene id: 9544:PYCR2
uniprot id: F7GP60
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:SYT17
gene id: 9544:SYT17
uniprot id: F7G138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9544:HAS2
gene id: 9544:HAS2
uniprot id: A0A8J8XV05
uniprot id: F6UTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9544:S100A9
gene id: 9544:S100A9
uniprot id: A0A8J8YHX5
uniprot id: F7F8G8
names: Similarity
messages: Belongs to the S-100 family.

9544:ST7L
gene id: 9544:ST7L
uniprot id: A0A5F7ZS33
uniprot id: F7CW28
uniprot id: F7CW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9544:NAA11
gene id: 9544:NAA11
uniprot id: A0A8J8XH26
uniprot id: F6U9M9
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9544:MRPL46
gene id: 9544:MRPL46
uniprot id: G7MYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9544:KCTD19
gene id: 9544:KCTD19
uniprot id: F7C1M2
names: Subcellular Location Annotation
messages: Cell membrane

9544:KCNMB4
gene id: 9544:KCNMB4
uniprot id: H9FT37
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9544:SRPX
gene id: 9544:SRPX
uniprot id: G7NT00
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NFE2L1
gene id: 9544:NFE2L1
uniprot id: F6T3Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:CREBL2
gene id: 9544:CREBL2
uniprot id: H9EPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9544:CDH8
gene id: 9544:CDH8
uniprot id: A0A8J8Y887
uniprot id: H9FND6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:MMP26
gene id: 9544:MMP26
uniprot id: A0A8J8YDI3
uniprot id: F6QMZ1
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:DNMT3B
gene id: 9544:DNMT3B
uniprot id: I2CWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9544:SNUPN
gene id: 9544:SNUPN
uniprot id: H9FND9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9544:TUBA3E
gene id: 9544:TUBA3E
uniprot id: F7H3X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9544:APOO
gene id: 9544:APOO
uniprot id: F7BCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9544:YWHAZ
gene id: 9544:YWHAZ
uniprot id: A0A8J8XBY4
uniprot id: F7HBD4
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:CNOT6
gene id: 9544:CNOT6
uniprot id: A0A8J8XLW0
uniprot id: F6ZS26
uniprot id: H9ZBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9544:SQSTM1
gene id: 9544:SQSTM1
uniprot id: H9G1C8
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9544:GPR37L1
gene id: 9544:GPR37L1
uniprot id: A0A8J8YNU6
uniprot id: F6TEF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:SKA2
gene id: 9544:SKA2
uniprot id: A0A8J8XK75
uniprot id: G7NHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9544:DSCC1
gene id: 9544:DSCC1
uniprot id: F7H261
names: Similarity
messages: Belongs to the DCC1 family.

9544:POP5
gene id: 9544:POP5
uniprot id: A0A8J8YDQ3
uniprot id: F7BZ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9544:MFAP5
gene id: 9544:MFAP5
uniprot id: F7FYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9544:SLC44A2
gene id: 9544:SLC44A2
uniprot id: A0A1D5QHJ6
uniprot id: A0A5K1UNU9
uniprot id: F6RT54
uniprot id: H9ES59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9544:NR1H2
gene id: 9544:NR1H2
uniprot id: A0A8J8XDQ9
uniprot id: F7F982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:AR
gene id: 9544:AR
uniprot id: Q6QT55
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318. Interacts with BUD31. Interacts with ARID4A. Interacts with ARID4B. Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity).
messages: Cytoplasm
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-510 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-65 by CDK9 regulates AR promoter selectivity and cell growth (By similarity).
messages: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
messages: Sumoylated on Lys-371 (major) and Lys-496 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).
messages: Transcriptional activity is enhanced by binding to RANBP9.

9544:MB
gene id: 9544:MB
uniprot id: A0A8J8Y6Y7
uniprot id: G7N3Q2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9544:BEST2
gene id: 9544:BEST2
uniprot id: A0A5F8AF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9544:LOC100270696
gene id: 9544:LOC100270696
uniprot id: A0A1D5QMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:SOD1
gene id: 9544:SOD1
uniprot id: H9FMP4
uniprot id: Q8HXQ0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9544:BRCA1
gene id: 9544:BRCA1
uniprot id: F7BG30
uniprot id: Q6J6I9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation.
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By simila…
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus
messages: Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-987 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation.
messages: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites.
messages: The RING-type zinc finger domain interacts with BAP1.

9544:TTC21A
gene id: 9544:TTC21A
uniprot id: F6TYS9
names: Similarity
messages: Belongs to the TTC21 family.

9544:HHIP
gene id: 9544:HHIP
uniprot id: A0A5F8ADQ8
uniprot id: F7HQP4
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TECRL
gene id: 9544:TECRL
uniprot id: A0A1D5QYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9544:TM2D3
gene id: 9544:TM2D3
uniprot id: I0FMG8
uniprot id: I0FMG9
names: Subcellular Location Annotation
messages: Membrane

9544:VIL1
gene id: 9544:VIL1
uniprot id: A0A8J8Y2B9
uniprot id: F7CQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9544:ERI1
gene id: 9544:ERI1
uniprot id: H9EX66
names: Subcellular Location Annotation
messages: Cytoplasm

9544:GALNTL6
gene id: 9544:GALNTL6
uniprot id: A0A8J8Y954
uniprot id: F7DBP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:ATRNL1
gene id: 9544:ATRNL1
uniprot id: A0A1D5RK70
uniprot id: F7FWX9
uniprot id: F7FWY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ARRDC1
gene id: 9544:ARRDC1
uniprot id: H9ZFD9
names: Similarity
messages: Belongs to the arrestin family.

9544:PIH1D2
gene id: 9544:PIH1D2
uniprot id: F6R9E8
names: Similarity
messages: Belongs to the PIH1 family.

9544:TEAD1
gene id: 9544:TEAD1
uniprot id: G7NDW4
names: Subcellular Location Annotation
messages: Nucleus

9544:DRAM2
gene id: 9544:DRAM2
uniprot id: A0A5F7ZPJ9
uniprot id: A0A8J8YPI5
uniprot id: G7MIG5
names: Subcellular Location Annotation
messages: Membrane

9544:OR4M1
gene id: 9544:OR4M1
uniprot id: F6U4U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SEPHS1
gene id: 9544:SEPHS1
uniprot id: H9Z6J2
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9544:MED24
gene id: 9544:MED24
uniprot id: H9G2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9544:MAB21L3
gene id: 9544:MAB21L3
uniprot id: A0A5K1U8F8
names: Similarity
messages: Belongs to the mab-21 family.

9544:GTF2H3
gene id: 9544:GTF2H3
uniprot id: H9ENW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9544:TSG101
gene id: 9544:TSG101
uniprot id: A0A8J8XCK1
uniprot id: G7NDS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

9544:CAB39L
gene id: 9544:CAB39L
uniprot id: A0A8J8YMV0
uniprot id: F6ZM32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9544:MOB3B
gene id: 9544:MOB3B
uniprot id: A0A8J8Y322
uniprot id: G7NFP7
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:NUP35
gene id: 9544:NUP35
uniprot id: A0A1D5R653
uniprot id: F6XL37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9544:GPR183
gene id: 9544:GPR183
uniprot id: G7NJJ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:DYRK1B
gene id: 9544:DYRK1B
uniprot id: A0A5F8AAW5
uniprot id: F7GIB1
uniprot id: H9G1R0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:TCEA1
gene id: 9544:TCEA1
uniprot id: A0A1D5Q638
uniprot id: H9FZ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9544:SLC37A4
gene id: 9544:SLC37A4
uniprot id: G7NCE1
uniprot id: H9Z2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9544:CYC1
gene id: 9544:CYC1
uniprot id: F7DMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:MAMU-F
gene id: 9544:MAMU-F
uniprot id: D7RD86
uniprot id: P33617
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

9544:ODC1
gene id: 9544:ODC1
uniprot id: H9EV40
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9544:SPNS2
gene id: 9544:SPNS2
uniprot id: A0A5F7ZI39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9544:SLITRK6
gene id: 9544:SLITRK6
uniprot id: F7GT29
names: Similarity
messages: Belongs to the SLITRK family.

9544:SCML2
gene id: 9544:SCML2
uniprot id: A0A8J8YMI1
uniprot id: G7NSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9544:RTN1
gene id: 9544:RTN1
uniprot id: F7HG96
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ACSL1
gene id: 9544:ACSL1
uniprot id: A0A8J8XRJ5
uniprot id: G7MSE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9544:CRYGB
gene id: 9544:CRYGB
uniprot id: A0A8J8XRL2
uniprot id: A3RLD7
uniprot id: A7KK36
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9544:TNFRSF14
gene id: 9544:TNFRSF14
uniprot id: Q0MSE4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GSTM3
gene id: 9544:GSTM3
uniprot id: A0A8J8XGH4
uniprot id: F7H5D7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9544:H2AFJ
gene id: 9544:H2AFJ
uniprot id: F7DHS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:CPSF6
gene id: 9544:CPSF6
uniprot id: A0A1D5R0C8
uniprot id: I0FJW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

9544:NPPC
gene id: 9544:NPPC
uniprot id: A0A8J8YIB4
uniprot id: F7DQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9544:GRIN3A
gene id: 9544:GRIN3A
uniprot id: F6VTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9544:CCN5
gene id: 9544:CCN5
uniprot id: G7N4S0
names: Similarity
messages: Belongs to the CCN family.

9544:ADH5
gene id: 9544:ADH5
uniprot id: H9Z5A5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9544:DDR1
gene id: 9544:DDR1
uniprot id: F6Y731
uniprot id: Q5TM72
names: Subcellular Location Annotation
messages: Membrane

9544:ATP5MC2
gene id: 9544:ATP5MC2
uniprot id: F7GGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:WDR48
gene id: 9544:WDR48
uniprot id: A0A8J8XM42
uniprot id: F6TZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9544:TMEM170A
gene id: 9544:TMEM170A
uniprot id: A0A8J8XFN2
uniprot id: F7G4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9544:GADD45B
gene id: 9544:GADD45B
uniprot id: A0A8J8XRF0
uniprot id: F7EBI6
names: Similarity
messages: Belongs to the GADD45 family.

9544:KCNA6
gene id: 9544:KCNA6
uniprot id: A0A5F8AKP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PDE9A
gene id: 9544:PDE9A
uniprot id: C4PBI8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:PABPC4
gene id: 9544:PABPC4
uniprot id: A0A8J8XET5
uniprot id: F6QKA5
uniprot id: F6XFF9
uniprot id: H9YYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:PPP2R5A
gene id: 9544:PPP2R5A
uniprot id: A0A8J8XVK3
uniprot id: F7APV7
uniprot id: G7MEM0
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:NKIRAS1
gene id: 9544:NKIRAS1
uniprot id: A0A8J8Y6V6
uniprot id: G7MJY0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9544:NDUFB9
gene id: 9544:NDUFB9
uniprot id: A0A8J8Y916
uniprot id: G7N032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:MSH6
gene id: 9544:MSH6
uniprot id: F6UF63
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9544:SEC11A
gene id: 9544:SEC11A
uniprot id: A0A1D5R670
uniprot id: A0A8J8XB25
uniprot id: F7D839
uniprot id: G7MYQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CLDN6
gene id: 9544:CLDN6
uniprot id: F7AWZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:GLCE
gene id: 9544:GLCE
uniprot id: A0A8J8XXX4
uniprot id: F7FIG3
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9544:CCL21
gene id: 9544:CCL21
uniprot id: Q8HYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Monomer. Binds to CCR7. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with TNFAIP6 (via Link domain).
messages: Secreted

9544:VASP
gene id: 9544:VASP
uniprot id: I0FG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9544:AVIL
gene id: 9544:AVIL
uniprot id: F7GJN7
names: Similarity
messages: Belongs to the villin/gelsolin family.

9544:DYRK2
gene id: 9544:DYRK2
uniprot id: F6PT02
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:GRPR
gene id: 9544:GRPR
uniprot id: F7HCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CCL24
gene id: 9544:CCL24
uniprot id: A0A8J8XG40
uniprot id: F6TX08
names: Subcellular Location Annotation
messages: Secreted

9544:CASQ2
gene id: 9544:CASQ2
uniprot id: A0A5K1UGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9544:LAMTOR3
gene id: 9544:LAMTOR3
uniprot id: A0A8J8YMA1
uniprot id: G7MTI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9544:MID1IP1
gene id: 9544:MID1IP1
uniprot id: A0A8J8YQ03
uniprot id: F7BK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9544:UBE2G1
gene id: 9544:UBE2G1
uniprot id: H9FZA3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:GRM8
gene id: 9544:GRM8
uniprot id: F6VUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:GNG13
gene id: 9544:GNG13
uniprot id: A0A8J8XV61
uniprot id: F6Q1E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:NRM
gene id: 9544:NRM
uniprot id: A0A8J8XN81
uniprot id: G7MRG0
uniprot id: Q5TM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9544:ANXA10
gene id: 9544:ANXA10
uniprot id: A0A1D5Q3F4
names: Similarity
messages: Belongs to the annexin family.

9544:WDYHV1
gene id: 9544:WDYHV1
uniprot id: A0A8J8XA66
uniprot id: F6YHY3
uniprot id: H9EVV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9544:EIF4EBP1
gene id: 9544:EIF4EBP1
uniprot id: A0A8J8YPN2
uniprot id: G7MZ42
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9544:NOG
gene id: 9544:NOG
uniprot id: F6VTK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9544:HAPLN4
gene id: 9544:HAPLN4
uniprot id: A0A1D5QQ66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RPS4Y2
gene id: 9544:RPS4Y2
uniprot id: B8YE08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:HSD17B4
gene id: 9544:HSD17B4
uniprot id: H9Z8E0
names: Subcellular Location Annotation
messages: Peroxisome

9544:RNF126
gene id: 9544:RNF126
uniprot id: H9ZB13
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:PDE6H
gene id: 9544:PDE6H
uniprot id: A0A8J8XUE8
uniprot id: F6SQF2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9544:TLR3
gene id: 9544:TLR3
uniprot id: Q3BBY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:IL25
gene id: 9544:IL25
uniprot id: G7MX46
names: Similarity
messages: Belongs to the IL-17 family.

9544:RTN3
gene id: 9544:RTN3
uniprot id: F7C1E9
uniprot id: H9Z0L1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:GBX2
gene id: 9544:GBX2
uniprot id: F6WW58
names: Subcellular Location Annotation
messages: Nucleus

9544:ALDH4A1
gene id: 9544:ALDH4A1
uniprot id: G7MHB6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:BTK
gene id: 9544:BTK
uniprot id: A0A8J8YBS4
uniprot id: F6V0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:SUZ12
gene id: 9544:SUZ12
uniprot id: A0A5F8A8X4
uniprot id: F6PUM4
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

9544:TAC3
gene id: 9544:TAC3
uniprot id: A0A5K1U8I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9544:ESCO2
gene id: 9544:ESCO2
uniprot id: F7FUZ4
names: Subcellular Location Annotation
messages: Nucleus

9544:GORASP1
gene id: 9544:GORASP1
uniprot id: A0A5K1UWY5
names: Similarity
messages: Belongs to the GORASP family.

9544:TMEM107
gene id: 9544:TMEM107
uniprot id: H9ERC2
names: Subcellular Location Annotation
messages: Membrane

9544:TM4SF4
gene id: 9544:TM4SF4
uniprot id: A0A1D5QM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9544:FFAR1
gene id: 9544:FFAR1
uniprot id: A0A8J8YKJ8
uniprot id: F6W3L4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:RBBP5
gene id: 9544:RBBP5
uniprot id: H9ENY9
uniprot id: H9YYG5
names: Subcellular Location Annotation
messages: Nucleus

9544:NLRP8
gene id: 9544:NLRP8
uniprot id: B0FNB1
names: Similarity
messages: Belongs to the NLRP family.

9544:ZPBP
gene id: 9544:ZPBP
uniprot id: A0A5F8ALX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9544:B3GNT9
gene id: 9544:B3GNT9
uniprot id: A0A8J8YQQ9
uniprot id: G7NQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SH3BP4
gene id: 9544:SH3BP4
uniprot id: F6T6Y1
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9544:FAAH2
gene id: 9544:FAAH2
uniprot id: A0A8J8Y2W9
uniprot id: F6VCV8
names: Similarity
messages: Belongs to the amidase family.

9544:OCIAD1
gene id: 9544:OCIAD1
uniprot id: A0A8J8YC82
uniprot id: F6U3Z7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9544:XCL1
gene id: 9544:XCL1
uniprot id: Q8HXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9544:LOC106993227
gene id: 9544:LOC106993227
uniprot id: A0A5F7ZCF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9544:CA10
gene id: 9544:CA10
uniprot id: F6RP09
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9544:AREG
gene id: 9544:AREG
uniprot id: A0A8J8YS56
uniprot id: F7D8W9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PPP6R3
gene id: 9544:PPP6R3
uniprot id: H9ESR3
uniprot id: H9ESU7
names: Similarity
messages: Belongs to the SAPS family.

9544:EFNB1
gene id: 9544:EFNB1
uniprot id: A0A8J8XRL4
uniprot id: G7NRT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:EIF2A
gene id: 9544:EIF2A
uniprot id: A0A8J8XVA5
uniprot id: F6WKS2
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9544:MUL1
gene id: 9544:MUL1
uniprot id: F7EZL0
names: Subcellular Location Annotation
messages: Membrane

9544:MAGI1
gene id: 9544:MAGI1
uniprot id: F6V3H6
names: Subcellular Location Annotation
messages: Membrane

9544:GNAT2
gene id: 9544:GNAT2
uniprot id: A0A8J8Y1P3
uniprot id: F6VKI4
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:RSPO3
gene id: 9544:RSPO3
uniprot id: F6SP05
names: Similarity
messages: Belongs to the R-spondin family.

9544:ELAVL4
gene id: 9544:ELAVL4
uniprot id: A0A1D5RHY3
uniprot id: A0A8J8XDK8
uniprot id: F6T409
uniprot id: F6T420
uniprot id: G7MGY7
uniprot id: H9FQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9544:DCTN1
gene id: 9544:DCTN1
uniprot id: F6T5J5
uniprot id: I2CWJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9544:SPECC1L
gene id: 9544:SPECC1L
uniprot id: F6WRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9544:LHFPL1
gene id: 9544:LHFPL1
uniprot id: A0A5F8AC39
uniprot id: A0A8J8XX04
uniprot id: G7NT64
names: Subcellular Location Annotation
messages: Membrane

9544:SGK2
gene id: 9544:SGK2
uniprot id: F7AQZ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:KIF5A
gene id: 9544:KIF5A
uniprot id: A0A8J8XFX8
uniprot id: G7N7G4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:LAMC1
gene id: 9544:LAMC1
uniprot id: F6WVB2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9544:LOC106992283
gene id: 9544:LOC106992283
uniprot id: A0A8J8XJG7
uniprot id: F7GAF4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9544:AANAT
gene id: 9544:AANAT
uniprot id: O97756
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acetyltransferase family. AANAT subfamily.
messages: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
messages: Cytoplasm
messages: Exhibits night/day variations with a 10-fold increased protein levels and activity at night in the pineal gland and a 5-fold increase in the retina. In both tissues, the mRNA levels remain constant.
messages: Highly expressed in pineal gland and in the photoreceptor outer segments in the retina. Expressed at about 100-fold lower levels in the pituitary gland and testis. Not detected in other tissues.
messages: Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-28 (By similarity). Phosphorylation on Ser-202 also allows binding to YWHAZ, but with lower affinity (By similarity). The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation (By similarity).
messages: cAMP-dependent phosphorylation regulates AANAT activity by promoting interaction with 14-3-3 proteins. Phosphorylation levels exhibit night/day variations, with an increase during nighttime.

9544:ERGIC1
gene id: 9544:ERGIC1
uniprot id: A0A5K1UES3
uniprot id: F6V791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9544:AZIN1
gene id: 9544:AZIN1
uniprot id: F7B9N8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9544:DNTT
gene id: 9544:DNTT
uniprot id: A0A8J8YQY9
uniprot id: F7A3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9544:SLC25A26
gene id: 9544:SLC25A26
uniprot id: A0A1D5RK04
uniprot id: A0A8J8XZ60
uniprot id: F7GC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:BANF2
gene id: 9544:BANF2
uniprot id: A0A1D5RL29
names: Subcellular Location Annotation
messages: Nucleus

9544:KRT7
gene id: 9544:KRT7
uniprot id: F7BW95
names: Similarity
messages: Belongs to the intermediate filament family.

9544:NRG2
gene id: 9544:NRG2
uniprot id: F6T2G3
uniprot id: F6T2Z6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:CSNK2A2
gene id: 9544:CSNK2A2
uniprot id: H9ENR6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:SNTA1
gene id: 9544:SNTA1
uniprot id: H9FYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9544:TLR6
gene id: 9544:TLR6
uniprot id: B3Y646
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CDR2
gene id: 9544:CDR2
uniprot id: F7HT75
names: Similarity
messages: Belongs to the CDR2 family.

9544:CDK5RAP3
gene id: 9544:CDK5RAP3
uniprot id: H9YZ21
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9544:CD164
gene id: 9544:CD164
uniprot id: A0A8J8XHG4
uniprot id: F7F631
uniprot id: F7F654
uniprot id: H9G1A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9544:AK4
gene id: 9544:AK4
uniprot id: A0A5F8A696
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9544:CNOT11
gene id: 9544:CNOT11
uniprot id: A0A8J8XIY9
uniprot id: F6RQB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9544:SLC52A2
gene id: 9544:SLC52A2
uniprot id: G7N0B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9544:CTSW
gene id: 9544:CTSW
uniprot id: A0A8J8YHW3
uniprot id: F7F868
names: Similarity
messages: Belongs to the peptidase C1 family.

9544:TM9SF1
gene id: 9544:TM9SF1
uniprot id: A0A8J8XZZ1
uniprot id: G7MX66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:KRTAP8-1
gene id: 9544:KRTAP8-1
uniprot id: F6WWY9
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:FIBIN
gene id: 9544:FIBIN
uniprot id: A0A8J8XPX0
uniprot id: F6X3Z2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9544:SPACA5
gene id: 9544:SPACA5
uniprot id: A0A8J8Y1Z0
uniprot id: F7FWH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9544:XPO6
gene id: 9544:XPO6
uniprot id: H9FRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9544:SLC13A3
gene id: 9544:SLC13A3
uniprot id: A0A1D5Q3G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9544:USP7
gene id: 9544:USP7
uniprot id: F6S6E3
uniprot id: H9FZM1
names: Similarity
messages: Belongs to the peptidase C19 family.

9544:CDC37
gene id: 9544:CDC37
uniprot id: A0A1D5RA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9544:MRPL53
gene id: 9544:MRPL53
uniprot id: A0A8J8XPN7
uniprot id: G7NAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9544:ECE1
gene id: 9544:ECE1
uniprot id: H9FQW5
names: Function
messages: Converts big endothelin-1 to endothelin-1.

9544:ATP1B3
gene id: 9544:ATP1B3
uniprot id: F6WUB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:MAP6
gene id: 9544:MAP6
uniprot id: F7D5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9544:OVOL3
gene id: 9544:OVOL3
uniprot id: F7A428
names: Subcellular Location Annotation
messages: Nucleus

9544:HNRNPA1
gene id: 9544:HNRNPA1
uniprot id: Q28521
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6, C9orf72, KHDRBS1, UBQLN2 (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.
messages: Nucleus
messages: Sumoylated.

9544:WDR35
gene id: 9544:WDR35
uniprot id: F6ZHP8
uniprot id: F7GV84
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9544:CDO1
gene id: 9544:CDO1
uniprot id: F7DU10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9544:NDNF
gene id: 9544:NDNF
uniprot id: G7MRW2
names: Subcellular Location Annotation
messages: Secreted

9544:SESN2
gene id: 9544:SESN2
uniprot id: F7FNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9544:KCTD21
gene id: 9544:KCTD21
uniprot id: A0A8J8XHI3
uniprot id: F7HK74
names: Subcellular Location Annotation
messages: Cell membrane

9544:FBL
gene id: 9544:FBL
uniprot id: H9YV05
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9544:NELL1
gene id: 9544:NELL1
uniprot id: F6QSV6
uniprot id: F7F740
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:OR5V1
gene id: 9544:OR5V1
uniprot id: A0A5F8AQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC699375
gene id: 9544:LOC699375
uniprot id: A0A5F7ZM69
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9544:IFT57
gene id: 9544:IFT57
uniprot id: I0FKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9544:CLK1
gene id: 9544:CLK1
uniprot id: I2CWF1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:TOR3A
gene id: 9544:TOR3A
uniprot id: F7H528
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9544:BORCS8
gene id: 9544:BORCS8
uniprot id: A0A1D5R9Y5
uniprot id: A0A8J8YC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9544:SOX3
gene id: 9544:SOX3
uniprot id: F6XQU8
names: Subcellular Location Annotation
messages: Nucleus

9544:SERPINA7
gene id: 9544:SERPINA7
uniprot id: F7DIN9
names: Similarity
messages: Belongs to the serpin family.

9544:ADA2
gene id: 9544:ADA2
uniprot id: A0A5K1UYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9544:CLDN10
gene id: 9544:CLDN10
uniprot id: A0A8J8Y9F3
uniprot id: F6ZXB6
uniprot id: F6ZXC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:PIK3R3
gene id: 9544:PIK3R3
uniprot id: F6WVD4
uniprot id: H9G113
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9544:FURIN
gene id: 9544:FURIN
uniprot id: A0A8J8XBL5
uniprot id: G7MVY8
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:KMO
gene id: 9544:KMO
uniprot id: A0A8J8YEK2
uniprot id: F6SV05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9544:BCL2A1
gene id: 9544:BCL2A1
uniprot id: A0A8J8XWL9
uniprot id: F7E8V5
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:NKIRAS2
gene id: 9544:NKIRAS2
uniprot id: A0A8J8XJC4
uniprot id: F7BYD9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9544:KRT82
gene id: 9544:KRT82
uniprot id: F7E5G2
names: Similarity
messages: Belongs to the intermediate filament family.

9544:KCNJ13
gene id: 9544:KCNJ13
uniprot id: A0A5F7ZVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:MYMK
gene id: 9544:MYMK
uniprot id: A0A8J8XJU8
uniprot id: F7HGL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9544:DENR
gene id: 9544:DENR
uniprot id: H9G148
names: Similarity
messages: Belongs to the DENR family.

9544:EHD1
gene id: 9544:EHD1
uniprot id: A0A8J8XE44
uniprot id: F6XYM2
uniprot id: G7NCH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9544:DIP2B
gene id: 9544:DIP2B
uniprot id: A0A8J8YJR2
uniprot id: G7N6Z1
names: Similarity
messages: Belongs to the DIP2 family.

9544:RNF31
gene id: 9544:RNF31
uniprot id: H9EUS9
names: Similarity
messages: Belongs to the RBR family.

9544:PPFIA3
gene id: 9544:PPFIA3
uniprot id: A0A8J8XWQ8
uniprot id: G7NLM7
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9544:CHAF1A
gene id: 9544:CHAF1A
uniprot id: H9Z3X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHAF1A family.
messages: Nucleus

9544:CCDC85A
gene id: 9544:CCDC85A
uniprot id: F7BVP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9544:SLC5A6
gene id: 9544:SLC5A6
uniprot id: F6PWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9544:TMEM14C
gene id: 9544:TMEM14C
uniprot id: F7B640
uniprot id: G8F1R2
names: Similarity
messages: Belongs to the TMEM14 family.

9544:EEF2
gene id: 9544:EEF2
uniprot id: A0A1D5QQX5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9544:CBX5
gene id: 9544:CBX5
uniprot id: A0A8J8Y6P4
uniprot id: F7C841
names: Subcellular Location Annotation
messages: Nucleus

9544:GNPAT
gene id: 9544:GNPAT
uniprot id: F6VSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9544:MRPL9
gene id: 9544:MRPL9
uniprot id: A0A8J8XKV3
uniprot id: F7EDQ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9544:RTD1B
gene id: 9544:RTD1B
uniprot id: P82271
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1 subunit A (RTD-1). An additional intersubunit disulfide bond is formed.
messages: RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35.
messages: RTD-1 expression begins early during granulocyte myelopoiesis.
messages: RTD-1 is 10-fold more present in cells than RTD-2.
messages: RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. RTD-2 is a cyclic homodimer composed of two subunits B; disulfide-linked.
messages: RTD-1 is expressed in bone marrow. Detected in promyelocytes, myelocytes and mature neutrophils and monocytes.

9544:CBS
gene id: 9544:CBS
uniprot id: A0A5K1U2N5
uniprot id: A0A8J8XBE8
uniprot id: G7MMI9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9544:ANXA6
gene id: 9544:ANXA6
uniprot id: H9ESF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9544:NME1
gene id: 9544:NME1
uniprot id: F6TRJ3
names: Similarity
messages: Belongs to the NDK family.

9544:KCNS2
gene id: 9544:KCNS2
uniprot id: A0A8J8Y2A5
uniprot id: F6PWB2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PSMB7
gene id: 9544:PSMB7
uniprot id: A0A8J8XZU7
uniprot id: F7E9M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9544:CAMK2A
gene id: 9544:CAMK2A
uniprot id: H9EMI1
uniprot id: H9EMI2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:GOLT1B
gene id: 9544:GOLT1B
uniprot id: A0A1D5R1M2
uniprot id: A0A8J8XM89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9544:SFXN4
gene id: 9544:SFXN4
uniprot id: I0FP47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9544:RUVBL1
gene id: 9544:RUVBL1
uniprot id: A0A8J8XMP3
uniprot id: F6VIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9544:SSBP2
gene id: 9544:SSBP2
uniprot id: A0A5K1U6F5
uniprot id: F6WQM9
uniprot id: I0FKM5
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC16A10
gene id: 9544:SLC16A10
uniprot id: F7FBA0
names: Subcellular Location Annotation
messages: Membrane

9544:PARP3
gene id: 9544:PARP3
uniprot id: F6ZFV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9544:KIFC3
gene id: 9544:KIFC3
uniprot id: A0A1D5Q1J5
uniprot id: A0A1D5QE16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:SAMHD1
gene id: 9544:SAMHD1
uniprot id: A0A8J8YMA9
uniprot id: G7N4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9544:GBF1
gene id: 9544:GBF1
uniprot id: F7GVX8
names: Subcellular Location Annotation
messages: Golgi apparatus

9544:ATP5MF
gene id: 9544:ATP5MF
uniprot id: H9ZFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9544:NNAT
gene id: 9544:NNAT
uniprot id: A0A5F8AAQ1
uniprot id: F6SKN9
uniprot id: G8F239
names: Similarity
messages: Belongs to the neuronatin family.

9544:MYO18A
gene id: 9544:MYO18A
uniprot id: H9ETW9
uniprot id: H9ETY4
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SNRPN
gene id: 9544:SNRPN
uniprot id: F7FI72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9544:GPR83
gene id: 9544:GPR83
uniprot id: A0A1D5R7E2
uniprot id: A0A8J8XBF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9544:ACTRT3
gene id: 9544:ACTRT3
uniprot id: F6Q5K2
names: Similarity
messages: Belongs to the actin family.

9544:SMAD5
gene id: 9544:SMAD5
uniprot id: F6YMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:RNF141
gene id: 9544:RNF141
uniprot id: A0A8J8YDJ8
uniprot id: F7AVV4
names: Function
messages: May be involved in spermatogenesis.

9544:SLC7A10
gene id: 9544:SLC7A10
uniprot id: F6WMI1
uniprot id: I0FTG8
names: Subcellular Location Annotation
messages: Membrane

9544:KCTD14
gene id: 9544:KCTD14
uniprot id: A0A8J8YE80
uniprot id: G7NEE9
names: Subcellular Location Annotation
messages: Cell membrane

9544:EBF3
gene id: 9544:EBF3
uniprot id: A0A5F8AHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:PHYHIP
gene id: 9544:PHYHIP
uniprot id: A0A8J8XK55
uniprot id: F7HAA3
names: Similarity
messages: Belongs to the PHYHIP family.

9544:NTNG1
gene id: 9544:NTNG1
uniprot id: A0A1D5QLF9
uniprot id: A0A1D5QRK2
uniprot id: A0A8J8XED8
uniprot id: F7GYH3
uniprot id: G7MIC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NXPE3
gene id: 9544:NXPE3
uniprot id: A0A8J8XBU1
uniprot id: F7EDF4
names: Similarity
messages: Belongs to the NXPE family.

9544:IDO1
gene id: 9544:IDO1
uniprot id: F6SGT6
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9544:EIF6
gene id: 9544:EIF6
uniprot id: A0A1D5R862
uniprot id: A0A8J8Y1R9
uniprot id: G7N4Z7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9544:DLC1
gene id: 9544:DLC1
uniprot id: A0A1D5QFD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

9544:THOC2
gene id: 9544:THOC2
uniprot id: F6RSZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9544:CDC123
gene id: 9544:CDC123
uniprot id: A0A8J8XAY5
uniprot id: F7HCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9544:LOC699110
gene id: 9544:LOC699110
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MON1A
gene id: 9544:MON1A
uniprot id: A0A1D5QTN8
uniprot id: A0A8J8YCQ1
uniprot id: G7ML79
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9544:ENTR1
gene id: 9544:ENTR1
uniprot id: F7DS27
names: Similarity
messages: Belongs to the ENTR1 family.

9544:SUB1
gene id: 9544:SUB1
uniprot id: F7AF44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9544:INTS3
gene id: 9544:INTS3
uniprot id: H9FYM8
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9544:PKIG
gene id: 9544:PKIG
uniprot id: A0A8J8YM98
uniprot id: F7CBH9
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9544:NPC1
gene id: 9544:NPC1
uniprot id: A0A5K1USA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9544:TM9SF4
gene id: 9544:TM9SF4
uniprot id: F7CJR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:MEGF9
gene id: 9544:MEGF9
uniprot id: F7C0W7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KIF17
gene id: 9544:KIF17
uniprot id: F7ES46
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:RHBDL3
gene id: 9544:RHBDL3
uniprot id: F7EP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9544:ATP5F1E
gene id: 9544:ATP5F1E
uniprot id: A0A8J8YGG2
uniprot id: Q6VEU4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9544:PGLYRP4
gene id: 9544:PGLYRP4
uniprot id: A0A8J8YEV9
uniprot id: F7F8I2
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9544:ACO1
gene id: 9544:ACO1
uniprot id: A0A5F8AQZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9544:LIN54
gene id: 9544:LIN54
uniprot id: A0A8J8YCK8
uniprot id: G7MSX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9544:CMTR1
gene id: 9544:CMTR1
uniprot id: A0A8J8Y9C5
uniprot id: F7BLE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9544:NF2
gene id: 9544:NF2
uniprot id: F6RPW5
uniprot id: F6RPZ9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9544:HSD17B3
gene id: 9544:HSD17B3
uniprot id: A0A1D5RKB3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:MCRIP1
gene id: 9544:MCRIP1
uniprot id: H9Z8I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9544:AMZ1
gene id: 9544:AMZ1
uniprot id: A0A5F7ZAF7
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9544:GSTA1
gene id: 9544:GSTA1
uniprot id: A0A5F7ZAC1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:TSNAX
gene id: 9544:TSNAX
uniprot id: H9FZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9544:TEDDM1
gene id: 9544:TEDDM1
uniprot id: F6WLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9544:CCL2
gene id: 9544:CCL2
uniprot id: A0A8J8YA47
uniprot id: P61275
uniprot id: Q71ME7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9544:IL17F
gene id: 9544:IL17F
uniprot id: A0A8J8XGQ6
uniprot id: F7HK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9544:HCN3
gene id: 9544:HCN3
uniprot id: A0A5F8AQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9544:LEPR
gene id: 9544:LEPR
uniprot id: F7DIP7
uniprot id: Q9MYL0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.
messages: Membrane
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-984 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1139 is required for STAT3 binding/activation (By similarity).
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-984 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1139 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.
messages: Present as a mixture of monomers and dimers. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
messages: Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
messages: Widely expressed. High expression of isoform B in liver, adipose tissue, hypothalamus and choroid plexus.

9544:CCNL1
gene id: 9544:CCNL1
uniprot id: H9EPW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9544:MSRB3
gene id: 9544:MSRB3
uniprot id: H9FSD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9544:GRPEL1
gene id: 9544:GRPEL1
uniprot id: F6PNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9544:CCDC22
gene id: 9544:CCDC22
uniprot id: I0FR27
names: Similarity
messages: Belongs to the CCDC22 family.

9544:RETREG1
gene id: 9544:RETREG1
uniprot id: F7D6D3
uniprot id: F7D6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9544:RBP5
gene id: 9544:RBP5
uniprot id: A0A8J8XUZ5
uniprot id: F7DNI3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:PNPT1
gene id: 9544:PNPT1
uniprot id: F7DK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

9544:CHST13
gene id: 9544:CHST13
uniprot id: F7HB73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MAEL
gene id: 9544:MAEL
uniprot id: A0A8J8YRF3
uniprot id: F7B842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9544:LOC700087
gene id: 9544:LOC700087
uniprot id: G7NLE4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9544:BRPF3
gene id: 9544:BRPF3
uniprot id: H9FSZ9
names: Subcellular Location Annotation
messages: Nucleus

9544:PEA15
gene id: 9544:PEA15
uniprot id: I0FW10
names: Subcellular Location Annotation
messages: Cytoplasm

9544:IL7R
gene id: 9544:IL7R
uniprot id: A0A1D5QDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9544:UBE2D1
gene id: 9544:UBE2D1
uniprot id: A0A8J8YC37
uniprot id: G7N2F6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:OXT
gene id: 9544:OXT
uniprot id: F7AXI7
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9544:HDAC9
gene id: 9544:HDAC9
uniprot id: A0A5F7ZSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus

9544:SLC30A10
gene id: 9544:SLC30A10
uniprot id: A0A8J8YMN9
uniprot id: F6ZX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:TYSND1
gene id: 9544:TYSND1
uniprot id: F7GWU1
uniprot id: F7GWW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9544:GAP43
gene id: 9544:GAP43
uniprot id: F7FEE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9544:HEXA
gene id: 9544:HEXA
uniprot id: F7GQ07
uniprot id: I0FR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9544:AGPAT5
gene id: 9544:AGPAT5
uniprot id: F6ZYV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PPP4R3C
gene id: 9544:PPP4R3C
uniprot id: F6W1B0
names: Similarity
messages: Belongs to the SMEK family.

9544:ARAP3
gene id: 9544:ARAP3
uniprot id: A0A1D5QLW8
uniprot id: A0A1D5RDA8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:VPS4B
gene id: 9544:VPS4B
uniprot id: A0A8J8XMF8
uniprot id: F7H6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:ACSS3
gene id: 9544:ACSS3
uniprot id: F6T734
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:AP3M2
gene id: 9544:AP3M2
uniprot id: A0A8J8XPL8
uniprot id: G7MZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9544:FAM110A
gene id: 9544:FAM110A
uniprot id: A0A8J8YG80
uniprot id: G7N2Q1
names: Similarity
messages: Belongs to the FAM110 family.

9544:FASLG
gene id: 9544:FASLG
uniprot id: P63307
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
messages: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
messages: Lysosome lumen
messages: Monoubiquitinated.
messages: N-glycosylated. Glycosylation enhances apoptotic activity.
messages: Nucleus
messages: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.

9544:SELENOW
gene id: 9544:SELENOW
uniprot id: P63303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Highest levels detected in skeletal muscle, tongue, heart and brain. Expressed at significantly higher levels in female skeletal muscle than in male and at slightly higher levels in female cardiac muscle than in male (at protein level). Also detected at low levels in liver.
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

9544:YKT6
gene id: 9544:YKT6
uniprot id: A0A8J8XVB6
uniprot id: F6PLE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9544:OR4B1
gene id: 9544:OR4B1
uniprot id: F6TM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TMEM63A
gene id: 9544:TMEM63A
uniprot id: A0A1D5QTM5
uniprot id: A0A5F8A9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9544:PDE3A
gene id: 9544:PDE3A
uniprot id: F7HBP7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:ACAD8
gene id: 9544:ACAD8
uniprot id: A0A5F8AIA9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9544:HIBADH
gene id: 9544:HIBADH
uniprot id: F6W2R9
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9544:TUBB
gene id: 9544:TUBB
uniprot id: A0A5F8AIX2
uniprot id: P69895
uniprot id: Q5TM69
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Heterodimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with PIFO. Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity). Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
messages: cytoskeleton

9544:FUT8
gene id: 9544:FUT8
uniprot id: A0A8J8XWH6
uniprot id: F7BVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9544:NDUFA5
gene id: 9544:NDUFA5
uniprot id: I0FJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:CLDN11
gene id: 9544:CLDN11
uniprot id: A0A8J8XX13
uniprot id: I0FS42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:GABRA4
gene id: 9544:GABRA4
uniprot id: A0A8J8XF17
uniprot id: F6YLN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:HOXB9
gene id: 9544:HOXB9
uniprot id: A0A5F7ZVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9544:SLC30A6
gene id: 9544:SLC30A6
uniprot id: H9FWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:SLC51A
gene id: 9544:SLC51A
uniprot id: F7GU27
names: Subcellular Location Annotation
messages: Membrane

9544:SOSTDC1
gene id: 9544:SOSTDC1
uniprot id: F7C9I3
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HOXC11
gene id: 9544:HOXC11
uniprot id: F6R720
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:LZIC
gene id: 9544:LZIC
uniprot id: A0A8J8Y4D7
uniprot id: F6YYT8
uniprot id: G7MGT6
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9544:KHDRBS1
gene id: 9544:KHDRBS1
uniprot id: H9EMX6
names: Similarity
messages: Belongs to the KHDRBS family.

9544:MATN2
gene id: 9544:MATN2
uniprot id: I0FJP2
uniprot id: I0FJP3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:FMR1
gene id: 9544:FMR1
uniprot id: I0FIR2
uniprot id: I0FIR3
uniprot id: I0FIR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9544:ALDH9A1
gene id: 9544:ALDH9A1
uniprot id: A0A8J8YRB2
uniprot id: G7MF77
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:KEG06 p07
gene id: 9544:KEG06_p07
uniprot id: Q6IYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

9544:SEMA6C
gene id: 9544:SEMA6C
uniprot id: F7AIQ7
uniprot id: I2CVL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TLR2
gene id: 9544:TLR2
uniprot id: B3Y618
uniprot id: B6CJY9
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9544:C1H1orf43
gene id: 9544:C1H1orf43
uniprot id: A0A5K1VKT7
uniprot id: A0A8J8XYZ2
uniprot id: F7GRW2
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9544:MAN1A1
gene id: 9544:MAN1A1
uniprot id: F6YY29
uniprot id: I2CU20
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9544:MYF5
gene id: 9544:MYF5
uniprot id: A0A8J8YCR5
uniprot id: F7HGT7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9544:MEIS1
gene id: 9544:MEIS1
uniprot id: A0A5F7ZKF0
uniprot id: F6UJJ2
uniprot id: F6WY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9544:ZNRD1
gene id: 9544:ZNRD1
uniprot id: F7H8M1
uniprot id: Q5TM50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9544:GPR65
gene id: 9544:GPR65
uniprot id: A0A8J8YH03
uniprot id: F7GWW3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SDR16C5
gene id: 9544:SDR16C5
uniprot id: A0A8J8XGS4
uniprot id: F6W524
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:LOC710527
gene id: 9544:LOC710527
uniprot id: F7ARE6
uniprot id: F7ARF7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9544:PLBD1
gene id: 9544:PLBD1
uniprot id: F6TC57
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9544:ENY2
gene id: 9544:ENY2
uniprot id: F7B6X1
uniprot id: H9EQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9544:MSTN
gene id: 9544:MSTN
uniprot id: A1C2U6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9544:SLC12A4
gene id: 9544:SLC12A4
uniprot id: H9ETV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:FAM129B
gene id: 9544:FAM129B
uniprot id: I0FUA6
names: Similarity
messages: Belongs to the Niban family.

9544:CTNS
gene id: 9544:CTNS
uniprot id: A0A8J8XW65
uniprot id: F7DR72
uniprot id: I2CW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9544:ATP6V0A2
gene id: 9544:ATP6V0A2
uniprot id: A0A8J8XCU3
uniprot id: G7N6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9544:GAB1
gene id: 9544:GAB1
uniprot id: A0A8J8YDH0
uniprot id: F6Q209
uniprot id: I0FQK0
names: Similarity
messages: Belongs to the GAB family.

9544:PPEF2
gene id: 9544:PPEF2
uniprot id: F6SFA1
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:ALKBH6
gene id: 9544:ALKBH6
uniprot id: F6X7J1
names: Similarity
messages: Belongs to the alkB family.

9544:SLITRK4
gene id: 9544:SLITRK4
uniprot id: A0A8J8YRE3
uniprot id: F7GI13
names: Similarity
messages: Belongs to the SLITRK family.

9544:VPS4A
gene id: 9544:VPS4A
uniprot id: A0A1D5R8T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:CPNE1
gene id: 9544:CPNE1
uniprot id: I2CTI9
names: Similarity
messages: Belongs to the copine family.

9544:PDE2A
gene id: 9544:PDE2A
uniprot id: B3VTJ2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:AADACL4
gene id: 9544:AADACL4
uniprot id: A0A5K1VJB0
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:TTR
gene id: 9544:TTR
uniprot id: A0A1D5QXZ0
uniprot id: A0A8J8XPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9544:PPP1R12A
gene id: 9544:PPP1R12A
uniprot id: I0FRY0
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9544:SNRPA1
gene id: 9544:SNRPA1
uniprot id: A0A8J8YEN2
uniprot id: G7MWB8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9544:COX7B2
gene id: 9544:COX7B2
uniprot id: A0A8J8Y4W0
uniprot id: G7MSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:THOC6
gene id: 9544:THOC6
uniprot id: A0A8J8YET4
uniprot id: F7DB82
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9544:PIWIL2
gene id: 9544:PIWIL2
uniprot id: E1AWN8
names: Similarity
messages: Belongs to the argonaute family.

9544:MYADM
gene id: 9544:MYADM
uniprot id: A0A8J8Y9Y0
uniprot id: G7NN51
names: Subcellular Location Annotation
messages: Membrane

9544:CBX3
gene id: 9544:CBX3
uniprot id: A0A1D5R706
uniprot id: H9FPI2
names: Subcellular Location Annotation
messages: Nucleus

9544:MME
gene id: 9544:MME
uniprot id: A0A8J8Y120
uniprot id: F7H3Y6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9544:LOC701574
gene id: 9544:LOC701574
uniprot id: A0A1D5QW91
uniprot id: A0A8J8YRZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:RAPGEF2
gene id: 9544:RAPGEF2
uniprot id: G7MS85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

9544:ITIH1
gene id: 9544:ITIH1
uniprot id: F7GAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9544:GATA4
gene id: 9544:GATA4
uniprot id: I2CWU8
names: Subcellular Location Annotation
messages: Nucleus

9544:PGS1
gene id: 9544:PGS1
uniprot id: G7NH04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9544:DOK4
gene id: 9544:DOK4
uniprot id: A0A8J8XDI8
uniprot id: F6VK00
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9544:TRAK1
gene id: 9544:TRAK1
uniprot id: G7MIY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9544:CCL11
gene id: 9544:CCL11
uniprot id: Q8HXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:TRIM22
gene id: 9544:TRIM22
uniprot id: A0A8J8XB53
uniprot id: B0F4M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9544:NMB
gene id: 9544:NMB
uniprot id: H9EYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9544:HBE1
gene id: 9544:HBE1
uniprot id: G7NE40
uniprot id: Q28507
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
messages: Red blood cells.
messages: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

9544:PARP16
gene id: 9544:PARP16
uniprot id: F6TWE1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:ZDHHC8
gene id: 9544:ZDHHC8
uniprot id: F7GKM4
uniprot id: H9ETV7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:YWHAQ
gene id: 9544:YWHAQ
uniprot id: F7DW30
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9544:IMPG2
gene id: 9544:IMPG2
uniprot id: F6WFP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9544:CRYZ
gene id: 9544:CRYZ
uniprot id: F7GRD2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9544:TAF12
gene id: 9544:TAF12
uniprot id: A0A8J8XSE9
uniprot id: F6TWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9544:KCTD20
gene id: 9544:KCTD20
uniprot id: A0A8J8XEF2
uniprot id: F7GEH1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:PRL
gene id: 9544:PRL
uniprot id: P55151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9544:KCTD8
gene id: 9544:KCTD8
uniprot id: F7EWZ5
names: Subcellular Location Annotation
messages: Cell membrane

9544:ALOX5AP
gene id: 9544:ALOX5AP
uniprot id: A0A8J8XMD5
uniprot id: G7NJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:KLC2
gene id: 9544:KLC2
uniprot id: F6YHS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9544:SENP1
gene id: 9544:SENP1
uniprot id: H9FTJ4
names: Similarity
messages: Belongs to the peptidase C48 family.

9544:AFF4
gene id: 9544:AFF4
uniprot id: A0A1D5QZT4
uniprot id: H9FSZ7
names: Similarity
messages: Belongs to the AF4 family.

9544:DCLK2
gene id: 9544:DCLK2
uniprot id: H9ES18
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:LAMB2
gene id: 9544:LAMB2
uniprot id: A0A8J8Y506
uniprot id: I0FRM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9544:TOR1B
gene id: 9544:TOR1B
uniprot id: H9ESY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9544:UPK1A
gene id: 9544:UPK1A
uniprot id: F7HHP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:RPL7A
gene id: 9544:RPL7A
uniprot id: F6ZCN6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9544:XRCC5
gene id: 9544:XRCC5
uniprot id: H9FZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9544:MRPL3
gene id: 9544:MRPL3
uniprot id: A0A8J8XC44
uniprot id: F6XHQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9544:NOSIP
gene id: 9544:NOSIP
uniprot id: A0A8J8XY85
uniprot id: H9ETT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9544:FGF17
gene id: 9544:FGF17
uniprot id: A0A7U3JW27
uniprot id: A0A8J8Y5D6
uniprot id: G7N0M4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:ACTN3
gene id: 9544:ACTN3
uniprot id: F7HER2
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:FXYD6
gene id: 9544:FXYD6
uniprot id: A0A5F8A3G6
uniprot id: A0A8J8YLS9
uniprot id: I0FSP6
names: Similarity
messages: Belongs to the FXYD family.

9544:TPPP
gene id: 9544:TPPP
uniprot id: F6YD17
names: Similarity
messages: Belongs to the TPPP family.

9544:RAB39B
gene id: 9544:RAB39B
uniprot id: A0A8J8XIE4
uniprot id: F6WUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9544:ABI1
gene id: 9544:ABI1
uniprot id: A0A5K1VKF7
uniprot id: F7C4B0
uniprot id: H9FNB1
uniprot id: H9FNB2
uniprot id: H9FNB3
uniprot id: H9YUY8
uniprot id: H9Z3W3
uniprot id: I0FGX7
uniprot id: I0FGX8
uniprot id: I2CUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9544:ALLC
gene id: 9544:ALLC
uniprot id: G8F1H6
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9544:TMEM70
gene id: 9544:TMEM70
uniprot id: A0A8J8XE33
uniprot id: F6VNP9
names: Similarity
messages: Belongs to the TMEM70 family.

9544:EXOSC4
gene id: 9544:EXOSC4
uniprot id: F7DHI6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LOC712543
gene id: 9544:LOC712543
uniprot id: H9Z073
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9544:PARD6A
gene id: 9544:PARD6A
uniprot id: I2CYN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9544:SYNGR4
gene id: 9544:SYNGR4
uniprot id: A0A8J8YFU3
uniprot id: F7H5G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9544:MAGOHB
gene id: 9544:MAGOHB
uniprot id: F7C465
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9544:LOC100426632
gene id: 9544:LOC100426632
uniprot id: F7HIT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:SGF29
gene id: 9544:SGF29
uniprot id: F6WF04
names: Subcellular Location Annotation
messages: Nucleus

9544:C15H9orf64
gene id: 9544:C15H9orf64
uniprot id: F6WZW8
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9544:TBC1D24
gene id: 9544:TBC1D24
uniprot id: F6TFP7
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

9544:PRORP
gene id: 9544:PRORP
uniprot id: F7D7G2
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9544:CNIH2
gene id: 9544:CNIH2
uniprot id: H9FSE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:LSM12
gene id: 9544:LSM12
uniprot id: F7GZM1
names: Similarity
messages: Belongs to the LSM12 family.

9544:API5
gene id: 9544:API5
uniprot id: F7EXC8
uniprot id: H9G121
names: Similarity
messages: Belongs to the API5 family.

9544:NTRK2
gene id: 9544:NTRK2
uniprot id: A0A5F7Z783
uniprot id: A0A8J8YD67
uniprot id: F7DGW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:GUK1
gene id: 9544:GUK1
uniprot id: I2CWX1
names: Similarity
messages: Belongs to the guanylate kinase family.

9544:KCNK12
gene id: 9544:KCNK12
uniprot id: A0A5F8AE23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:SNED1
gene id: 9544:SNED1
uniprot id: F7C1N9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:EZH1
gene id: 9544:EZH1
uniprot id: H9EPI3
names: Subcellular Location Annotation
messages: Nucleus

9544:BDH1
gene id: 9544:BDH1
uniprot id: A0A8J8XCY6
uniprot id: G7MKG3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:DEGS2
gene id: 9544:DEGS2
uniprot id: A0A5F7ZY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CXCL8
gene id: 9544:CXCL8
uniprot id: P67813
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9544:ZNF711
gene id: 9544:ZNF711
uniprot id: A0A8J8XXM1
uniprot id: G7NSD8
uniprot id: H9EMP3
names: Subcellular Location Annotation
messages: Nucleus

9544:ZNF280C
gene id: 9544:ZNF280C
uniprot id: A0A5F7ZWA2
uniprot id: F6T648
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9544:THRB
gene id: 9544:THRB
uniprot id: F7G9B9
uniprot id: F7G9C3
uniprot id: G7MJY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:ANAPC10
gene id: 9544:ANAPC10
uniprot id: F7GPG7
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9544:LOC698176
gene id: 9544:LOC698176
uniprot id: F7HFG9
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9544:IDH3G
gene id: 9544:IDH3G
uniprot id: A0A1D5Q3Z8
uniprot id: H9FTW9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9544:CCR4
gene id: 9544:CCR4
uniprot id: A0A8J8XQY5
uniprot id: F7GUA3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:ST6GAL1
gene id: 9544:ST6GAL1
uniprot id: A0A8J8XF67
uniprot id: F6TW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:BLVRA
gene id: 9544:BLVRA
uniprot id: F7H4J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9544:AKR1C1
gene id: 9544:AKR1C1
uniprot id: H9FQN9
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:CHST1
gene id: 9544:CHST1
uniprot id: F6TF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:GALNT7
gene id: 9544:GALNT7
uniprot id: A0A1D5R2F9
uniprot id: F6ZUC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:SNRPE
gene id: 9544:SNRPE
uniprot id: A0A8J8XC02
uniprot id: G7MEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9544:CAMSAP2
gene id: 9544:CAMSAP2
uniprot id: A0A8J8XKB0
uniprot id: F6VME1
uniprot id: F6VME9
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9544:PRPF4B
gene id: 9544:PRPF4B
uniprot id: H9G1E3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9544:PLA2G2E
gene id: 9544:PLA2G2E
uniprot id: A0A5F8AEH8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9544:ATP8A1
gene id: 9544:ATP8A1
uniprot id: F7F3Y6
uniprot id: H9EM46
uniprot id: H9FNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:MRPS12
gene id: 9544:MRPS12
uniprot id: A0A5F8AS78
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9544:EIF3K
gene id: 9544:EIF3K
uniprot id: A0A8J8Y4M4
uniprot id: F6XGZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9544:RBPJ
gene id: 9544:RBPJ
uniprot id: A0A1D5R3Z3
uniprot id: H9FTZ8
uniprot id: H9FTZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9544:BDKRB2
gene id: 9544:BDKRB2
uniprot id: A0A1D5QT55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:NLK
gene id: 9544:NLK
uniprot id: A0A5F7ZQF4
uniprot id: A0A8J8YSP2
uniprot id: G7NGI5
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9544:ENTPD6
gene id: 9544:ENTPD6
uniprot id: F6RV58
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:ZDHHC2
gene id: 9544:ZDHHC2
uniprot id: F7GMT9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:SETD3
gene id: 9544:SETD3
uniprot id: A0A8J8XZY5
uniprot id: I0FVL8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9544:NT5DC1
gene id: 9544:NT5DC1
uniprot id: F7G2B7
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9544:LMOD2
gene id: 9544:LMOD2
uniprot id: F7BU89
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9544:PRKCQ
gene id: 9544:PRKCQ
uniprot id: H9FX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9544:SLC2A4
gene id: 9544:SLC2A4
uniprot id: G7NIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9544:ATP6V1A
gene id: 9544:ATP6V1A
uniprot id: F7HT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9544:JAKMIP2
gene id: 9544:JAKMIP2
uniprot id: F7AAH0
uniprot id: F7AAI8
uniprot id: H9F0T2
names: Similarity
messages: Belongs to the JAKMIP family.

9544:SLC9A1
gene id: 9544:SLC9A1
uniprot id: H9FYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane

9544:IL18
gene id: 9544:IL18
uniprot id: Q9BGI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9544:CASTOR1
gene id: 9544:CASTOR1
uniprot id: A0A8J8XFG4
uniprot id: F7GBS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9544:MAP4
gene id: 9544:MAP4
uniprot id: A0A5F8ARB7
uniprot id: F7BEU8
uniprot id: F7HR80
names: Subcellular Location Annotation
messages: cytoskeleton

9544:FAM8A1
gene id: 9544:FAM8A1
uniprot id: I0FSE7
names: Subcellular Location Annotation
messages: Membrane

9544:OAS1
gene id: 9544:OAS1
uniprot id: A4LAA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9544:PPFIA4
gene id: 9544:PPFIA4
uniprot id: A0A1D5Q7H8
uniprot id: A0A1D5QW96
uniprot id: F7HM51
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9544:SPRR1B
gene id: 9544:SPRR1B
uniprot id: G7MDP7
uniprot id: P35322
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
messages: Cytoplasm
messages: During squamous differentiation of epidermal keratinocytes.

9544:HOOK1
gene id: 9544:HOOK1
uniprot id: F7A7W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:LITAF
gene id: 9544:LITAF
uniprot id: F6S7A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9544:LOC716363
gene id: 9544:LOC716363
uniprot id: G7NEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CDS2
gene id: 9544:CDS2
uniprot id: A0A8J8XN71
uniprot id: G7N2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9544:SLC7A7
gene id: 9544:SLC7A7
uniprot id: A0A8J8Y1D8
uniprot id: G7MX23
names: Subcellular Location Annotation
messages: Membrane

9544:LSM7
gene id: 9544:LSM7
uniprot id: H9ZA07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9544:CD200R1
gene id: 9544:CD200R1
uniprot id: A0A075M976
names: Similarity
messages: Belongs to the CD200R family.

9544:MED13L
gene id: 9544:MED13L
uniprot id: F7FWX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:ZMYND10
gene id: 9544:ZMYND10
uniprot id: A0A8J8XB43
uniprot id: F7DJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9544:OGFRL1
gene id: 9544:OGFRL1
uniprot id: F7FLT3
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9544:HNRNPF
gene id: 9544:HNRNPF
uniprot id: A0A8J8XK70
uniprot id: F6UEF5
names: Subcellular Location Annotation
messages: nucleoplasm

9544:AKAP8L
gene id: 9544:AKAP8L
uniprot id: F7DN43
uniprot id: H9FSX8
names: Similarity
messages: Belongs to the AKAP95 family.

9544:SLC25A51
gene id: 9544:SLC25A51
uniprot id: F7F3D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:LOC717247
gene id: 9544:LOC717247
uniprot id: A0A1D5Q2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9544:PTGER3
gene id: 9544:PTGER3
uniprot id: F7HS70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TMEM161B
gene id: 9544:TMEM161B
uniprot id: F7HLT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9544:TAGLN3
gene id: 9544:TAGLN3
uniprot id: A0A8J8Y7B5
uniprot id: G7MK53
names: Similarity
messages: Belongs to the calponin family.

9544:FGFR2
gene id: 9544:FGFR2
uniprot id: A0A1D5QFH7
uniprot id: A0A1D5QYN7
uniprot id: A0A8J8Y1Y1
uniprot id: F7A5X3
uniprot id: G7N1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:LRRC8B
gene id: 9544:LRRC8B
uniprot id: A0A1D5QGF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:TFCP2
gene id: 9544:TFCP2
uniprot id: A0A8J8XAN2
uniprot id: H9YW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9544:SMARCA1
gene id: 9544:SMARCA1
uniprot id: F6TKC4
uniprot id: F7F0X3
uniprot id: H9FYQ7
uniprot id: I0FUD4
uniprot id: I2CVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9544:ATP6V0D2
gene id: 9544:ATP6V0D2
uniprot id: A0A8J8XJ67
uniprot id: F7GTJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:PAEP
gene id: 9544:PAEP
uniprot id: Q5BM07
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:LOC694015
gene id: 9544:LOC694015
uniprot id: A0A5F8AS91
names: Similarity
messages: Belongs to the FAM25 family.

9544:TP53RK
gene id: 9544:TP53RK
uniprot id: H9EW85
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9544:DOHH
gene id: 9544:DOHH
uniprot id: A0A5F8AHZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9544:VPS41
gene id: 9544:VPS41
uniprot id: A0A8J8XQV6
uniprot id: G7MLG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9544:PPP2CA
gene id: 9544:PPP2CA
uniprot id: F7H808
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:CMC4
gene id: 9544:CMC4
uniprot id: A0A8J8XD19
uniprot id: F6QM91
names: Similarity
messages: Belongs to the CMC4 family.

9544:NUP88
gene id: 9544:NUP88
uniprot id: G7NI51
names: Subcellular Location Annotation
messages: nuclear pore complex

9544:TAS2R39
gene id: 9544:TAS2R39
uniprot id: Q645S5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9544:TNIP2
gene id: 9544:TNIP2
uniprot id: F7BKB7
uniprot id: F7HQP7
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LOC703272
gene id: 9544:LOC703272
uniprot id: F7HHB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MAP2
gene id: 9544:MAP2
uniprot id: A0A1D5R639
uniprot id: F6Y370
uniprot id: G7N8T0
uniprot id: I2CXY8
names: Subcellular Location Annotation
messages: cytoskeleton

9544:KCNC2
gene id: 9544:KCNC2
uniprot id: F7BL49
uniprot id: F7BL65
uniprot id: F7EIZ1
uniprot id: H9FU55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:OSM
gene id: 9544:OSM
uniprot id: F7GF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

9544:LPAR1
gene id: 9544:LPAR1
uniprot id: F7EZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9544:SCNN1G
gene id: 9544:SCNN1G
uniprot id: A0A8J8YGP4
uniprot id: F6U4Y2
names: Subcellular Location Annotation
messages: Membrane

9544:LETM2
gene id: 9544:LETM2
uniprot id: G7MZ49
names: Subcellular Location Annotation
messages: Membrane

9544:LHFPL3
gene id: 9544:LHFPL3
uniprot id: H9FU60
names: Subcellular Location Annotation
messages: Membrane

9544:LOC702608
gene id: 9544:LOC702608
uniprot id: A0A5F7ZXM9
names: Similarity
messages: Belongs to the TMEM14 family.

9544:MBP
gene id: 9544:MBP
uniprot id: A0A1D5QD23
uniprot id: A0A8J8YSG1
uniprot id: G7NKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9544:HSPA4L
gene id: 9544:HSPA4L
uniprot id: A0A1D5R641
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:BRF1
gene id: 9544:BRF1
uniprot id: F6RDQ4
names: Similarity
messages: Belongs to the TFIIB family.

9544:SERPINA11
gene id: 9544:SERPINA11
uniprot id: A0A8J8XTW2
uniprot id: F7EJG1
names: Similarity
messages: Belongs to the serpin family.

9544:LOC704750
gene id: 9544:LOC704750
uniprot id: F6XZ76
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:AP4M1
gene id: 9544:AP4M1
uniprot id: F7DJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9544:ARL11
gene id: 9544:ARL11
uniprot id: G7NK52
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:KHDC1L
gene id: 9544:KHDC1L
uniprot id: A0A8J8XLF8
uniprot id: G7MPQ2
names: Similarity
messages: Belongs to the KHDC1 family.

9544:FLCN
gene id: 9544:FLCN
uniprot id: H9ERY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9544:SRP9
gene id: 9544:SRP9
uniprot id: A0A8J8XYF9
uniprot id: G7MEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9544:SLC7A9
gene id: 9544:SLC7A9
uniprot id: A0A8J8YCY1
uniprot id: F6XDS9
names: Subcellular Location Annotation
messages: Membrane

9544:FRZB
gene id: 9544:FRZB
uniprot id: A0A8J8YNC6
uniprot id: F7BWZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9544:PRKCZ
gene id: 9544:PRKCZ
uniprot id: F6ZZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9544:PBX1
gene id: 9544:PBX1
uniprot id: F6WM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:RAB3IL1
gene id: 9544:RAB3IL1
uniprot id: F6S434
names: Similarity
messages: Belongs to the SEC2 family.

9544:CLDN16
gene id: 9544:CLDN16
uniprot id: F7FN74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:TCEAL1
gene id: 9544:TCEAL1
uniprot id: A0A8J8Y8R3
uniprot id: A2D671
uniprot id: G7NSV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).
messages: Nucleus

9544:RMI1
gene id: 9544:RMI1
uniprot id: F6VJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9544:CDK20
gene id: 9544:CDK20
uniprot id: Q5EDC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Monomer. Interacts with TBC1D32 and MAK.
messages: Nucleus
messages: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).
messages: cilium

9544:RBP4
gene id: 9544:RBP4
uniprot id: H9FY19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9544:SMIM12
gene id: 9544:SMIM12
uniprot id: H9ENZ6
names: Similarity
messages: Belongs to the SMIM12 family.

9544:APOBEC3A
gene id: 9544:APOBEC3A
uniprot id: F6M3K4
names: Subcellular Location Annotation
messages: Cytoplasm

9544:HOOK2
gene id: 9544:HOOK2
uniprot id: F6U5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:TRIM34
gene id: 9544:TRIM34
uniprot id: F6ZTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9544:CHUK
gene id: 9544:CHUK
uniprot id: A0A1D5Q734
uniprot id: A0A8J8XZ28
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CD247
gene id: 9544:CD247
uniprot id: Q09TJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9544:STAC3
gene id: 9544:STAC3
uniprot id: A0A8J8Y188
uniprot id: F7DEB5
uniprot id: F7H7S2
names: Subcellular Location Annotation
messages: sarcolemma

9544:GLUD1
gene id: 9544:GLUD1
uniprot id: H9Z7V8
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9544:KCNF1
gene id: 9544:KCNF1
uniprot id: A0A8J8YMG1
uniprot id: G7NBA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:SUMF1
gene id: 9544:SUMF1
uniprot id: A0A5K1VGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9544:TMEM231
gene id: 9544:TMEM231
uniprot id: H9EWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9544:COX16
gene id: 9544:COX16
uniprot id: G7MYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9544:S100A6
gene id: 9544:S100A6
uniprot id: A0A8J8YFR0
uniprot id: F7DI51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9544:ACTR1A
gene id: 9544:ACTR1A
uniprot id: A0A1D5RHA9
uniprot id: A0A8J8XBJ8
names: Similarity
messages: Belongs to the actin family.

9544:CCNE1
gene id: 9544:CCNE1
uniprot id: F7BEI4
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9544:LCLAT1
gene id: 9544:LCLAT1
uniprot id: A0A8J8YL28
uniprot id: F6QWR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CCDC58
gene id: 9544:CCDC58
uniprot id: F7HMS8
names: Similarity
messages: Belongs to the MIX23 family.

9544:GNG11
gene id: 9544:GNG11
uniprot id: A0A8J8XW29
uniprot id: G7MLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:MCM3
gene id: 9544:MCM3
uniprot id: A0A1D5Q7N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:WASL
gene id: 9544:WASL
uniprot id: F7BU81
names: Subcellular Location Annotation
messages: Nucleus

9544:GJD2
gene id: 9544:GJD2
uniprot id: F7F204
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:PPP2R2D
gene id: 9544:PPP2R2D
uniprot id: F6X3A7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:NAE1
gene id: 9544:NAE1
uniprot id: F6RFF8
uniprot id: H9G1D3
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9544:SRPX2
gene id: 9544:SRPX2
uniprot id: A0A8J8YP93
uniprot id: A3FEK9
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9544:PPEF1
gene id: 9544:PPEF1
uniprot id: A0A8J8Y171
uniprot id: F7C4V6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:HIGD1B
gene id: 9544:HIGD1B
uniprot id: A0A8J8YHD0
uniprot id: F6ZP04
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9544:NDUFS8
gene id: 9544:NDUFS8
uniprot id: A0A8J8Y768
uniprot id: F7EFK7
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9544:USP24
gene id: 9544:USP24
uniprot id: A0A5F8A5B3
names: Similarity
messages: Belongs to the peptidase C19 family.

9544:DNAJB14
gene id: 9544:DNAJB14
uniprot id: H9EUC0
names: Subcellular Location Annotation
messages: Membrane

9544:SLC6A8
gene id: 9544:SLC6A8
uniprot id: H9ENL8
uniprot id: H9ENL9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

9544:DSP
gene id: 9544:DSP
uniprot id: H9YUU2
names: Subcellular Location Annotation
messages: cytoskeleton

9544:ACTR2
gene id: 9544:ACTR2
uniprot id: F7BAD3
uniprot id: I2CYF0
names: Similarity
messages: Belongs to the actin family.

9544:NPM1
gene id: 9544:NPM1
uniprot id: F7AWI0
uniprot id: F7AWJ2
names: Similarity
messages: Belongs to the nucleoplasmin family.

9544:NUDT18
gene id: 9544:NUDT18
uniprot id: A0A5F8A1R1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9544:SMIM24
gene id: 9544:SMIM24
uniprot id: F7CUU7
names: Subcellular Location Annotation
messages: Membrane

9544:AP3M1
gene id: 9544:AP3M1
uniprot id: A0A1D5QZK2
uniprot id: A0A8J8Y6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9544:BUD31
gene id: 9544:BUD31
uniprot id: A0A8J8YH32
uniprot id: I2CY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9544:DESI1
gene id: 9544:DESI1
uniprot id: A0A8J8YFG0
uniprot id: G7N3Z4
names: Similarity
messages: Belongs to the DeSI family.

9544:SSBP1
gene id: 9544:SSBP1
uniprot id: A0A5F8AR45
uniprot id: A0A8J8Y2U4
uniprot id: F6X3C0
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9544:LTA4H
gene id: 9544:LTA4H
uniprot id: I0FLC3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9544:CMTM3
gene id: 9544:CMTM3
uniprot id: F7HQG0
names: Subcellular Location Annotation
messages: Membrane

9544:ATP6V1H
gene id: 9544:ATP6V1H
uniprot id: F6SP98
uniprot id: H9FVN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:KAT2A
gene id: 9544:KAT2A
uniprot id: H9FSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9544:NELFCD
gene id: 9544:NELFCD
uniprot id: A0A1D5RAZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9544:ADCK1
gene id: 9544:ADCK1
uniprot id: A0A1D5RB81
uniprot id: A0A8J8YS71
uniprot id: H9ER45
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9544:CCR6
gene id: 9544:CCR6
uniprot id: F6VQA9
uniprot id: Q8HZR7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:RAB39A
gene id: 9544:RAB39A
uniprot id: A0A5F7ZUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9544:PRTFDC1
gene id: 9544:PRTFDC1
uniprot id: F6YAY4
uniprot id: F6YAZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9544:TRIM10
gene id: 9544:TRIM10
uniprot id: Q5TM54
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9544:ARPIN
gene id: 9544:ARPIN
uniprot id: H9EX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

9544:MTX2
gene id: 9544:MTX2
uniprot id: A0A1D5R816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:LOC715827
gene id: 9544:LOC715827
uniprot id: G7MYJ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SLC35F6
gene id: 9544:SLC35F6
uniprot id: A0A8J8Y0A9
uniprot id: H9ERJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9544:HIP1
gene id: 9544:HIP1
uniprot id: F7EPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

9544:FAM83G
gene id: 9544:FAM83G
uniprot id: A0A1D5Q8U1
uniprot id: G8F169
names: Similarity
messages: Belongs to the FAM83 family.

9544:LOC717274
gene id: 9544:LOC717274
uniprot id: F6USN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:BCHE
gene id: 9544:BCHE
uniprot id: H9FXZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9544:AMDHD1
gene id: 9544:AMDHD1
uniprot id: F7H1F5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9544:MED14
gene id: 9544:MED14
uniprot id: A0A1D5Q627
uniprot id: A0A1D5QHV7
uniprot id: F7BPL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9544:CD46
gene id: 9544:CD46
uniprot id: F7DTF4
uniprot id: F7DTG0
uniprot id: I0FRS6
uniprot id: O19127
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9544:NRP1
gene id: 9544:NRP1
uniprot id: A0A8J8YRP3
uniprot id: F6WJ42
uniprot id: F7HHM6
uniprot id: F7HHN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:KEAP1
gene id: 9544:KEAP1
uniprot id: A0A8J8YT76
uniprot id: G7NL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9544:DYNLL1
gene id: 9544:DYNLL1
uniprot id: H9H2R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9544:TUBB2B
gene id: 9544:TUBB2B
uniprot id: A0A5F8A9E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:NDUFC1
gene id: 9544:NDUFC1
uniprot id: A0A8J8YE66
uniprot id: F7EDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:MINAR2
gene id: 9544:MINAR2
uniprot id: A0A1D5QJF2
names: Similarity
messages: Belongs to the MINAR family.

9544:FAM13B
gene id: 9544:FAM13B
uniprot id: A0A5F8APY2
uniprot id: A0A8J8Y3C7
uniprot id: F7HLD0
names: Similarity
messages: Belongs to the FAM13 family.

9544:STX3
gene id: 9544:STX3
uniprot id: A0A1D5Q2C9
names: Similarity
messages: Belongs to the syntaxin family.

9544:VAT1
gene id: 9544:VAT1
uniprot id: Q3I1S1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9544:SEMA4C
gene id: 9544:SEMA4C
uniprot id: A0A8J8YL13
uniprot id: H9EW83
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ACTRT1
gene id: 9544:ACTRT1
uniprot id: A0A8J8XJS7
uniprot id: G7NRD2
names: Similarity
messages: Belongs to the actin family.

9544:BRK1
gene id: 9544:BRK1
uniprot id: H9Z3A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9544:C10H20orf24
gene id: 9544:C10H20orf24
uniprot id: A0A5F8ABP4
uniprot id: A0A8J8XS53
uniprot id: F7GYH5
names: Subcellular Location Annotation
messages: Membrane

9544:SF3B6
gene id: 9544:SF3B6
uniprot id: A0A1D5RF54
uniprot id: A0A8J8XF05
names: Subcellular Location Annotation
messages: Nucleus

9544:PLA2G15
gene id: 9544:PLA2G15
uniprot id: A0A1D5RAG6
uniprot id: A0A8J8XQP7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:SGTB
gene id: 9544:SGTB
uniprot id: A0A8J8XVG6
uniprot id: G7MU68
names: Similarity
messages: Belongs to the SGT family.

9544:GALNT1
gene id: 9544:GALNT1
uniprot id: A0A8J8Y6A0
uniprot id: G7NKL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:MTNR1B
gene id: 9544:MTNR1B
uniprot id: F7F3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SRFBP1
gene id: 9544:SRFBP1
uniprot id: H9Z3N7
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9544:LOC721435
gene id: 9544:LOC721435
uniprot id: F7GSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ARHGAP32
gene id: 9544:ARHGAP32
uniprot id: A0A5F8AFZ7
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9544:EIF3G
gene id: 9544:EIF3G
uniprot id: F7HE98
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9544:SLC35E4
gene id: 9544:SLC35E4
uniprot id: A0A8J8XX74
uniprot id: G7N3L8
names: Subcellular Location Annotation
messages: Membrane

9544:PTPN12
gene id: 9544:PTPN12
uniprot id: A0A1D5RIQ8
uniprot id: F7EGH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9544:PTMA
gene id: 9544:PTMA
uniprot id: F7GZS2
uniprot id: I2CYA9
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:RBBP7
gene id: 9544:RBBP7
uniprot id: A0A8J8XUE4
uniprot id: F7GGZ4
uniprot id: F7GGZ7
names: Subcellular Location Annotation
messages: Nucleus

9544:CD59
gene id: 9544:CD59
uniprot id: A0A8J8XK53
uniprot id: F6QCT1
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

9544:C3H7orf25
gene id: 9544:C3H7orf25
uniprot id: G7MLF6
names: Similarity
messages: Belongs to the UPF0415 family.

9544:PRRX2
gene id: 9544:PRRX2
uniprot id: A0A5F8A377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9544:CTNNA1
gene id: 9544:CTNNA1
uniprot id: H9Z5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

9544:KCNV2
gene id: 9544:KCNV2
uniprot id: A0A5F8AIT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:ACLY
gene id: 9544:ACLY
uniprot id: A0A1D5QVG7
uniprot id: G7NIJ9
uniprot id: H9FUT3
uniprot id: H9FUT4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9544:CHD6
gene id: 9544:CHD6
uniprot id: F6VZQ8
uniprot id: F6VZS6
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9544:AURKA
gene id: 9544:AURKA
uniprot id: F7GNU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9544:GCN1
gene id: 9544:GCN1
uniprot id: A0A5K1VRX8
names: Similarity
messages: Belongs to the GCN1 family.

9544:MCHR1
gene id: 9544:MCHR1
uniprot id: Q8MJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with NCDN.
messages: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

9544:PTPRU
gene id: 9544:PTPRU
uniprot id: F6R5G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9544:REEP2
gene id: 9544:REEP2
uniprot id: H9FVE8
uniprot id: I2CTM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CD74
gene id: 9544:CD74
uniprot id: F7E9S4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KCNK3
gene id: 9544:KCNK3
uniprot id: I2CUN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:YES1
gene id: 9544:YES1
uniprot id: F6ZR07
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:FNTA
gene id: 9544:FNTA
uniprot id: I0FQC8
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9544:LDB3
gene id: 9544:LDB3
uniprot id: F6QFV3
names: Subcellular Location Annotation
messages: Z line

9544:KCTD3
gene id: 9544:KCTD3
uniprot id: F7FRD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KCTD3 family.
messages: Cell membrane

9544:ASB16
gene id: 9544:ASB16
uniprot id: F7BVZ8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:LOC714001
gene id: 9544:LOC714001
uniprot id: F6TWY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:FADS3
gene id: 9544:FADS3
uniprot id: F6YUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9544:LGR4
gene id: 9544:LGR4
uniprot id: F6QK18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:RPS6KB1
gene id: 9544:RPS6KB1
uniprot id: H9ENT4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:NARF
gene id: 9544:NARF
uniprot id: F6TW76
names: Similarity
messages: Belongs to the NARF family.

9544:ARF4
gene id: 9544:ARF4
uniprot id: A0A1D5RH41
uniprot id: I0FRJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9544:PIK3CG
gene id: 9544:PIK3CG
uniprot id: A0A8J8YMM1
uniprot id: F6W7C8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:LAMP3
gene id: 9544:LAMP3
uniprot id: A0A5F7ZF43
uniprot id: Q8MJJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMP family.
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
messages: Lysosome membrane
messages: Monomer. Interacts with FURIN.

9544:CYP2C75
gene id: 9544:CYP2C75
uniprot id: Q6GUQ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:PON3
gene id: 9544:PON3
uniprot id: A0A8J8XCB8
uniprot id: F7H7I9
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9544:C15H9orf116
gene id: 9544:C15H9orf116
uniprot id: A0A8J8XCZ1
uniprot id: G7NF86
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9544:NMNAT2
gene id: 9544:NMNAT2
uniprot id: A0A8J8YEU3
uniprot id: F7BCS0
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9544:EML4
gene id: 9544:EML4
uniprot id: F7GAG9
uniprot id: G7N9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9544:TBP
gene id: 9544:TBP
uniprot id: F6SEF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9544:WSCD2
gene id: 9544:WSCD2
uniprot id: F6R2N2
names: Similarity
messages: Belongs to the WSCD family.

9544:RAB3D
gene id: 9544:RAB3D
uniprot id: F6UG33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9544:MTCH2
gene id: 9544:MTCH2
uniprot id: A0A1D5RG12
uniprot id: H9ETT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:LMBR1L
gene id: 9544:LMBR1L
uniprot id: A0A5K1UXT6
names: Similarity
messages: Belongs to the LIMR family.

9544:RELL2
gene id: 9544:RELL2
uniprot id: A0A8J8YBH3
uniprot id: F6V688
names: Similarity
messages: Belongs to the RELT family.

9544:ALDH1L1
gene id: 9544:ALDH1L1
uniprot id: A0A1D5QNH6
uniprot id: A0A8J8YPK4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9544:TBK1
gene id: 9544:TBK1
uniprot id: A0A8J8XXL8
uniprot id: F7DBZ3
names: Subcellular Location Annotation
messages: Cytoplasm

9544:IRGQ
gene id: 9544:IRGQ
uniprot id: F7GL16
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9544:BZW2
gene id: 9544:BZW2
uniprot id: A0A8J8XN68
uniprot id: F7HNR9
names: Similarity
messages: Belongs to the BZW family.

9544:MYOG
gene id: 9544:MYOG
uniprot id: A0A5F8A6G3
names: Subcellular Location Annotation
messages: Nucleus

9544:H1FX
gene id: 9544:H1FX
uniprot id: F6Z1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:RAD23B
gene id: 9544:RAD23B
uniprot id: H9YX93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9544:MRRF
gene id: 9544:MRRF
uniprot id: F6S9C1
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9544:DCST2
gene id: 9544:DCST2
uniprot id: F7EGN2
names: Subcellular Location Annotation
messages: Membrane

9544:NFIB
gene id: 9544:NFIB
uniprot id: A0A1D5QSR0
uniprot id: F7GTP3
uniprot id: G7NFZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9544:SARAF
gene id: 9544:SARAF
uniprot id: A0A8J8XII5
uniprot id: F7BVH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9544:DEFB124
gene id: 9544:DEFB124
uniprot id: G7N557
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:DUSP7
gene id: 9544:DUSP7
uniprot id: F7GK32
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:MRPL28
gene id: 9544:MRPL28
uniprot id: F6Y8S5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9544:HEXB
gene id: 9544:HEXB
uniprot id: A0A8J8YJE2
uniprot id: F7FNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9544:ARPC4
gene id: 9544:ARPC4
uniprot id: H9FNE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9544:VPS8
gene id: 9544:VPS8
uniprot id: F7ACL5
uniprot id: G7MJ44
names: Similarity
messages: Belongs to the VPS8 family.

9544:SPP1
gene id: 9544:SPP1
uniprot id: F7F5M6
uniprot id: G8F1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9544:ZEB1
gene id: 9544:ZEB1
uniprot id: H9FZ12
uniprot id: I0FUL9
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9544:CBFA2T3
gene id: 9544:CBFA2T3
uniprot id: A0A5F7ZYF2
uniprot id: A0A5F8AB43
names: Similarity
messages: Belongs to the CBFA2T family.

9544:ACTC1
gene id: 9544:ACTC1
uniprot id: A0A8J8YF68
uniprot id: F7F210
names: Similarity
messages: Belongs to the actin family.

9544:CMBL
gene id: 9544:CMBL
uniprot id: A0A8J8XLP7
uniprot id: F7GKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9544:SCML4
gene id: 9544:SCML4
uniprot id: F7GHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9544:GCK
gene id: 9544:GCK
uniprot id: A0A1D5QSW0
uniprot id: A0A8J8Y216
uniprot id: F6PLU3
names: Similarity
messages: Belongs to the hexokinase family.

9544:GPR17
gene id: 9544:GPR17
uniprot id: F7HM53
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GDAP1
gene id: 9544:GDAP1
uniprot id: A0A8J8XR57
uniprot id: F6X699
names: Similarity
messages: Belongs to the GST superfamily.

9544:CLPS
gene id: 9544:CLPS
uniprot id: F6SG32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9544:NMT2
gene id: 9544:NMT2
uniprot id: F7HEZ3
uniprot id: H9ET97
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9544:CNNM1
gene id: 9544:CNNM1
uniprot id: A0A5F7Z9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9544:CA13
gene id: 9544:CA13
uniprot id: A0A1D5QB60
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9544:SNX11
gene id: 9544:SNX11
uniprot id: A0A8J8YT32
uniprot id: F7BF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9544:DOK5
gene id: 9544:DOK5
uniprot id: F7ERM3
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9544:PKN1
gene id: 9544:PKN1
uniprot id: H9FX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9544:MIGA1
gene id: 9544:MIGA1
uniprot id: A0A5F7Z9X3
uniprot id: F7H243
names: Similarity
messages: Belongs to the mitoguardin family.

9544:FAM13A
gene id: 9544:FAM13A
uniprot id: A0A1D5QKZ7
names: Similarity
messages: Belongs to the FAM13 family.

9544:RAD9A
gene id: 9544:RAD9A
uniprot id: H9FXY2
names: Similarity
messages: Belongs to the rad9 family.

9544:PIGC
gene id: 9544:PIGC
uniprot id: A0A8J8XU12
uniprot id: F7FCE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9544:MDC1
gene id: 9544:MDC1
uniprot id: Q5TM68
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AX, which requires phosphorylation of H2AX. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN. Interacts with CHEK2, which requires ATM-mediated phosphorylation within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain) (By similarity).
messages: Nucleus
messages: Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).
messages: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
messages: Sumoylation at Lys-1924 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.
messages: Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. In MDC1, these repeats are required for localization to chromatin which flanks sites of DNA damage marked by 'Ser-139' phosphorylation of H2AX (By similarity).
messages: Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.

9544:PKNOX2
gene id: 9544:PKNOX2
uniprot id: A0A8J8XU96
uniprot id: G7NCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9544:SLC7A8
gene id: 9544:SLC7A8
uniprot id: A0A8J8Y8U8
uniprot id: F7CUB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9544:BTN2A2
gene id: 9544:BTN2A2
uniprot id: H9Z4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9544:DNPEP
gene id: 9544:DNPEP
uniprot id: H9Z081
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9544:PADI6
gene id: 9544:PADI6
uniprot id: A0A8J8XMQ5
uniprot id: F6X3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9544:TBCE
gene id: 9544:TBCE
uniprot id: A0A8J8YD04
uniprot id: G7MFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9544:SLC4A4
gene id: 9544:SLC4A4
uniprot id: A0A8J8XE16
uniprot id: F7FRN6
uniprot id: G7MT45
uniprot id: H9G181
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ZSCAN20
gene id: 9544:ZSCAN20
uniprot id: G7MIA7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:PET117
gene id: 9544:PET117
uniprot id: A0A8J8YPK8
uniprot id: F7DFJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9544:DTNBP1
gene id: 9544:DTNBP1
uniprot id: F6SN96
names: Similarity
messages: Belongs to the dysbindin family.

9544:IRX1
gene id: 9544:IRX1
uniprot id: A0A5F7ZE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9544:TM4SF18
gene id: 9544:TM4SF18
uniprot id: I0FP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9544:LOC696872
gene id: 9544:LOC696872
uniprot id: A0A8J8XDH1
uniprot id: F7HAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:ESD
gene id: 9544:ESD
uniprot id: H9FR54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9544:DHRS3
gene id: 9544:DHRS3
uniprot id: A0A8J8YHK7
uniprot id: F6U5I2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:PSMC6
gene id: 9544:PSMC6
uniprot id: H9FXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9544:CLRN3
gene id: 9544:CLRN3
uniprot id: A0A8J8Y299
uniprot id: F7GCH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9544:SPPL3
gene id: 9544:SPPL3
uniprot id: H9EPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9544:CEBPB
gene id: 9544:CEBPB
uniprot id: I2CUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9544:ZNF445
gene id: 9544:ZNF445
uniprot id: H9Z8J6
names: Subcellular Location Annotation
messages: Nucleus

9544:POU6F1
gene id: 9544:POU6F1
uniprot id: A0A1D5QL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9544:TPD52L2
gene id: 9544:TPD52L2
uniprot id: A0A1D5QXB8
uniprot id: A0A1D5RA40
names: Similarity
messages: Belongs to the TPD52 family.

9544:MGST1
gene id: 9544:MGST1
uniprot id: A0A1D5RL31
uniprot id: A0A8J8YPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9544:DVL1
gene id: 9544:DVL1
uniprot id: A0A1D5QEW3
uniprot id: H9Z605
names: Similarity
messages: Belongs to the DSH family.

9544:TRIM5
gene id: 9544:TRIM5
uniprot id: Q0PF16
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with MAP3K7/TAK1, TAB2 and TAB3 (By similarity). Interacts with HSPA8/HSC70, PSMC2, PSMC4, PSMC5 and PSMD7 (PubMed:20053985, PubMed:22078707). Interacts with SQSTM1 (PubMed:20357094, PubMed:25127057). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with TRIM6 and TRIM34 (PubMed:21680743). Interacts with BECN1; GABARAP (PubMed:25127057). Interacts with ULK1 (phosphorylated form), GABARAPL1, GABARAPL2, MAP1LC3A and MAP1LC3C (By similarity).
messages: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
messages: Cytoplasm
messages: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
messages: Nucleus
messages: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (By similarity). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (PubMed:21680743).
messages: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs.
messages: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.

9544:SKA1
gene id: 9544:SKA1
uniprot id: F6YL00
names: Similarity
messages: Belongs to the SKA1 family.

9544:GRIK2
gene id: 9544:GRIK2
uniprot id: H9EM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:CFD
gene id: 9544:CFD
uniprot id: H9EXC1
names: Function
messages: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

9544:SULT1E1
gene id: 9544:SULT1E1
uniprot id: F6RUQ2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:ADIPOR2
gene id: 9544:ADIPOR2
uniprot id: A0A8J8XEN1
uniprot id: I0FV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:HSD17B10
gene id: 9544:HSD17B10
uniprot id: A0A8J8YG31
uniprot id: F7CV42
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:MMP9
gene id: 9544:MMP9
uniprot id: A0A8J8Y654
uniprot id: H9Z944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9544:DCLK1
gene id: 9544:DCLK1
uniprot id: A0A1D5R4Y2
uniprot id: A0A5F8ABD1
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:GPRC5A
gene id: 9544:GPRC5A
uniprot id: A0A5F8ALP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:ELOVL1
gene id: 9544:ELOVL1
uniprot id: A0A8J8XVL8
uniprot id: G7MGL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9544:NSA2
gene id: 9544:NSA2
uniprot id: H9Z4B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9544:IL6ST
gene id: 9544:IL6ST
uniprot id: A0A8J8YAN3
uniprot id: G7MTS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9544:SLC7A3
gene id: 9544:SLC7A3
uniprot id: F7FKL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9544:HSPA14
gene id: 9544:HSPA14
uniprot id: A0A8J8XZG5
uniprot id: G7N1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9544:LZTS2
gene id: 9544:LZTS2
uniprot id: F7AYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9544:LIMK2
gene id: 9544:LIMK2
uniprot id: H9FUC0
uniprot id: H9FUC1
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9544:MGAT4B
gene id: 9544:MGAT4B
uniprot id: F7EET9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:GPKOW
gene id: 9544:GPKOW
uniprot id: F7D1Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9544:CSGALNACT1
gene id: 9544:CSGALNACT1
uniprot id: A0A8J8XJF8
uniprot id: F7H635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:PHTF2
gene id: 9544:PHTF2
uniprot id: F7EGG0
uniprot id: I0FTM7
names: Subcellular Location Annotation
messages: Membrane

9544:CREB3L4
gene id: 9544:CREB3L4
uniprot id: A0A8J8YIJ0
uniprot id: F6VJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:BLOC1S6
gene id: 9544:BLOC1S6
uniprot id: G7MX85
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9544:KRT39
gene id: 9544:KRT39
uniprot id: F7GFM5
names: Similarity
messages: Belongs to the intermediate filament family.

9544:NUBP2
gene id: 9544:NUBP2
uniprot id: H9FN33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9544:EML2
gene id: 9544:EML2
uniprot id: A0A1D5R3D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9544:BRAF
gene id: 9544:BRAF
uniprot id: A0A1D5Q9W4
uniprot id: A0A5F8A7V3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9544:SLIT1
gene id: 9544:SLIT1
uniprot id: F7CX22
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:SEPTIN9
gene id: 9544:SEPTIN9
uniprot id: H9EV03
uniprot id: I2CTF1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9544:SNX2
gene id: 9544:SNX2
uniprot id: A0A5F8AK91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9544:EPHA7
gene id: 9544:EPHA7
uniprot id: A0A8J8XG70
uniprot id: G7MPY1
names: Subcellular Location Annotation
messages: Membrane

9544:TPH1
gene id: 9544:TPH1
uniprot id: F7B7G4
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9544:SPIN1
gene id: 9544:SPIN1
uniprot id: A0A8J8XB65
uniprot id: G7NGG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9544:CD79A
gene id: 9544:CD79A
uniprot id: A0A8J8XN05
uniprot id: G7NLK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TMEM17
gene id: 9544:TMEM17
uniprot id: A0A8J8XTD8
uniprot id: G7NA58
names: Subcellular Location Annotation
messages: Membrane

9544:GOSR1
gene id: 9544:GOSR1
uniprot id: A0A5K1TXI0
uniprot id: H9G254
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9544:DMRTA2
gene id: 9544:DMRTA2
uniprot id: A0A5F7ZPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9544:METTL2A
gene id: 9544:METTL2A
uniprot id: A0A1D5RB77
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9544:NCEH1
gene id: 9544:NCEH1
uniprot id: F6PMM4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:NKX2-2
gene id: 9544:NKX2-2
uniprot id: A0A8J8XIN4
uniprot id: F7HHQ2
names: Subcellular Location Annotation
messages: Nucleus

9544:TMED2
gene id: 9544:TMED2
uniprot id: A0A5F7ZL65
uniprot id: H9EPG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:PTH
gene id: 9544:PTH
uniprot id: A0A5F7ZGK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9544:SLC4A7
gene id: 9544:SLC4A7
uniprot id: F6RVU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9544:CLUH
gene id: 9544:CLUH
uniprot id: A0A1D5QEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9544:PNRC1
gene id: 9544:PNRC1
uniprot id: H9FP54
names: Subcellular Location Annotation
messages: Nucleus

9544:SEPTIN8
gene id: 9544:SEPTIN8
uniprot id: H9YYL9
uniprot id: H9Z6U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9544:RPL39
gene id: 9544:RPL39
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:LOC713189
gene id: 9544:LOC713189
uniprot id: A0A8J8YHM3
uniprot id: G7MDR2
names: Similarity
messages: Belongs to the S-100 family.

9544:RARS
gene id: 9544:RARS
uniprot id: H9FXZ9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:NADK
gene id: 9544:NADK
uniprot id: F7FZM8
names: Similarity
messages: Belongs to the NAD kinase family.

9544:WDR12
gene id: 9544:WDR12
uniprot id: H9FX18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9544:CEBPZ
gene id: 9544:CEBPZ
uniprot id: F7GTT7
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9544:CPLANE2
gene id: 9544:CPLANE2
uniprot id: A0A8J8Y6W3
uniprot id: F7FNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9544:PEMT
gene id: 9544:PEMT
uniprot id: F7H990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9544:AWAT1
gene id: 9544:AWAT1
uniprot id: A0A8J8YID6
uniprot id: F6SLT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9544:HOXA5
gene id: 9544:HOXA5
uniprot id: A0A5F8A1H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:URM1
gene id: 9544:URM1
uniprot id: I0FVD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9544:VPS37B
gene id: 9544:VPS37B
uniprot id: A0A1D5QWC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:CXCL10
gene id: 9544:CXCL10
uniprot id: Q8MIZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity).
messages: Secreted

9544:LASP1
gene id: 9544:LASP1
uniprot id: F7CPT5
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9544:GSTT1
gene id: 9544:GSTT1
uniprot id: A0A023JCR6
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:MTMR4
gene id: 9544:MTMR4
uniprot id: I2CVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9544:MPV17L2
gene id: 9544:MPV17L2
uniprot id: F7ASV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9544:LPAR3
gene id: 9544:LPAR3
uniprot id: A0A8J8XU65
uniprot id: F6S7Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PEX19
gene id: 9544:PEX19
uniprot id: H9ERK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9544:KCNK2
gene id: 9544:KCNK2
uniprot id: A0A1D5QMX8
uniprot id: A0A8J8XNW9
uniprot id: F7CHV4
uniprot id: F7GUQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:NR3C1
gene id: 9544:NR3C1
uniprot id: H9FTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9544:TRIM54
gene id: 9544:TRIM54
uniprot id: A0A8J8XU71
uniprot id: F7B8H2
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Nucleus
messages: Z line

9544:RLN2
gene id: 9544:RLN2
uniprot id: A0A8J8XWZ2
uniprot id: B1AAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9544:UCKL1
gene id: 9544:UCKL1
uniprot id: I0FIN0
names: Similarity
messages: Belongs to the uridine kinase family.

9544:CACNA2D1
gene id: 9544:CACNA2D1
uniprot id: A0A1D5QVR4
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9544:STX6
gene id: 9544:STX6
uniprot id: A0A5K1U1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9544:EXOC6B
gene id: 9544:EXOC6B
uniprot id: H9ENB4
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:SLC35A1
gene id: 9544:SLC35A1
uniprot id: F7GAL6
uniprot id: I0FNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9544:GTF2H1
gene id: 9544:GTF2H1
uniprot id: H9FTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9544:STMN4
gene id: 9544:STMN4
uniprot id: A0A1D5Q8D7
uniprot id: F6ZYT6
names: Similarity
messages: Belongs to the stathmin family.

9544:RCAN3
gene id: 9544:RCAN3
uniprot id: A0A8J8XQD1
uniprot id: G7MHN8
names: Similarity
messages: Belongs to the RCAN family.

9544:SNX10
gene id: 9544:SNX10
uniprot id: F7E6U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9544:KXD1
gene id: 9544:KXD1
uniprot id: F7GN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9544:PELI2
gene id: 9544:PELI2
uniprot id: H9YY61
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9544:SUPT6H
gene id: 9544:SUPT6H
uniprot id: A0A8J8Y836
uniprot id: G7NGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9544:DHX9
gene id: 9544:DHX9
uniprot id: F6W5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9544:LOC698764
gene id: 9544:LOC698764
uniprot id: F6YS39
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9544:HEBP1
gene id: 9544:HEBP1
uniprot id: A0A8J8XJ98
uniprot id: F6UQB6
names: Similarity
messages: Belongs to the HEBP family.

9544:LOC709417
gene id: 9544:LOC709417
uniprot id: A0A5K1VTR3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:PHKB
gene id: 9544:PHKB
uniprot id: F6RC44
uniprot id: I0FI56
uniprot id: I0FSM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9544:POMC
gene id: 9544:POMC
uniprot id: A0A5F8AUI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

9544:LDAH
gene id: 9544:LDAH
uniprot id: A0A1D5Q6Z1
uniprot id: F6ZP20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9544:SERPINB1
gene id: 9544:SERPINB1
uniprot id: A0A1D5RIS2
uniprot id: A0A8J8YAW7
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9544:POLE2
gene id: 9544:POLE2
uniprot id: F6ZV13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9544:SLC9A9
gene id: 9544:SLC9A9
uniprot id: H9FT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9544:HYI
gene id: 9544:HYI
uniprot id: F7GXP8
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9544:DDIT3
gene id: 9544:DDIT3
uniprot id: A0A8J8YS40
uniprot id: F6WA37
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9544:COQ10A
gene id: 9544:COQ10A
uniprot id: H9EST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9544:ZDHHC9
gene id: 9544:ZDHHC9
uniprot id: A0A8J8YD68
uniprot id: G7NRE0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:LOC700258
gene id: 9544:LOC700258
uniprot id: F7HMY6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9544:CSNK1A1L
gene id: 9544:CSNK1A1L
uniprot id: A0A8J8YKA8
uniprot id: F7AM42
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:SCN5A
gene id: 9544:SCN5A
uniprot id: F7CEN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:KCTD15
gene id: 9544:KCTD15
uniprot id: A0A5K1VP15
names: Subcellular Location Annotation
messages: Cell membrane

9544:KMT5B
gene id: 9544:KMT5B
uniprot id: A0A8J8XPF0
uniprot id: F7CK15
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9544:KIAA1324L
gene id: 9544:KIAA1324L
uniprot id: H9ES20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9544:CLIP1
gene id: 9544:CLIP1
uniprot id: A0A1D5QUX4
uniprot id: A0A5F8AM53
uniprot id: F6T4A4
names: Subcellular Location Annotation
messages: cytoskeleton

9544:PTGER2
gene id: 9544:PTGER2
uniprot id: A0A8J8XGH0
uniprot id: F7HTJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:AOX4
gene id: 9544:AOX4
uniprot id: M1ZMN2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9544:TNKS2
gene id: 9544:TNKS2
uniprot id: H9ZDV5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:GSTO1
gene id: 9544:GSTO1
uniprot id: F6SPY0
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9544:ACER2
gene id: 9544:ACER2
uniprot id: A0A8J8YJN2
uniprot id: G7NFX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MGAT5B
gene id: 9544:MGAT5B
uniprot id: G7NGZ1
uniprot id: H9FQB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:COPB1
gene id: 9544:COPB1
uniprot id: A0A8J8Y7V0
uniprot id: G7NDV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9544:ADM
gene id: 9544:ADM
uniprot id: A0A1D5Q865
uniprot id: A0A5F7ZL85
uniprot id: A0A8J8YHT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9544:SDHAF3
gene id: 9544:SDHAF3
uniprot id: F6TUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9544:PDZK1IP1
gene id: 9544:PDZK1IP1
uniprot id: A0A8J8XAM9
uniprot id: F7DPL6
names: Subcellular Location Annotation
messages: Membrane

9544:GHSR
gene id: 9544:GHSR
uniprot id: F6Z4B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9544:FABP4
gene id: 9544:FABP4
uniprot id: A0A8J8YQQ6
uniprot id: F7GLY0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:WNT7B
gene id: 9544:WNT7B
uniprot id: F7HJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:TSPYL1
gene id: 9544:TSPYL1
uniprot id: H9FZ82
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:ACSM1
gene id: 9544:ACSM1
uniprot id: A0A8J8Y4B7
uniprot id: F6Z2L2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:P2RX4
gene id: 9544:P2RX4
uniprot id: F7DXP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9544:HMMR
gene id: 9544:HMMR
uniprot id: F7CKK0
names: Subcellular Location Annotation
messages: spindle

9544:TGFBI
gene id: 9544:TGFBI
uniprot id: F6YTU1
names: Subcellular Location Annotation
messages: extracellular matrix

9544:ARGLU1
gene id: 9544:ARGLU1
uniprot id: F7HNY2
names: Similarity
messages: Belongs to the UPF0430 family.

9544:AP2M1
gene id: 9544:AP2M1
uniprot id: H9FPP5
uniprot id: H9Z538
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9544:EMSY
gene id: 9544:EMSY
uniprot id: A0A1D5QTH7
uniprot id: A0A5F8AV15
uniprot id: A0A8J8XJP8
uniprot id: F6YRZ7
uniprot id: F6YXL7
uniprot id: G7NED5
names: Subcellular Location Annotation
messages: Nucleus

9544:SPIN4
gene id: 9544:SPIN4
uniprot id: A0A8J8XCB2
uniprot id: F7EXC3
names: Similarity
messages: Belongs to the SPIN/STSY family.

9544:MOG
gene id: 9544:MOG
uniprot id: A0A5F7ZWY4
uniprot id: F7GXZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9544:ITK
gene id: 9544:ITK
uniprot id: A0A8J8XH04
uniprot id: F7GS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:LCN10
gene id: 9544:LCN10
uniprot id: F7GSI9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:HNRNPUL1
gene id: 9544:HNRNPUL1
uniprot id: H9EMU1
names: Subcellular Location Annotation
messages: Nucleus

9544:OLA1
gene id: 9544:OLA1
uniprot id: H9EPI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9544:CDKN2AIPNL
gene id: 9544:CDKN2AIPNL
uniprot id: H9G1P6
names: Similarity
messages: Belongs to the CARF family.

9544:HGS
gene id: 9544:HGS
uniprot id: H9ZF73
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9544:G0S2
gene id: 9544:G0S2
uniprot id: A0A8J8XDK2
uniprot id: G7MEP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9544:FAM3A
gene id: 9544:FAM3A
uniprot id: F7GMH0
uniprot id: H9EUR0
uniprot id: I2CT86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9544:TRMT13
gene id: 9544:TRMT13
uniprot id: A0A8J8YC54
uniprot id: F6YWH7
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9544:SCN1B
gene id: 9544:SCN1B
uniprot id: F6QID2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9544:ITGAV
gene id: 9544:ITGAV
uniprot id: H9ETF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:RWDD3
gene id: 9544:RWDD3
uniprot id: H9EX82
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:MTFR1L
gene id: 9544:MTFR1L
uniprot id: F7BDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9544:NR2F2
gene id: 9544:NR2F2
uniprot id: A0A1D5Q708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:CIT
gene id: 9544:CIT
uniprot id: A0A5K1U3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9544:PHPT1
gene id: 9544:PHPT1
uniprot id: H9ER03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

9544:MAGI2
gene id: 9544:MAGI2
uniprot id: A0A1D5QV36
names: Subcellular Location Annotation
messages: Membrane

9544:RTF2
gene id: 9544:RTF2
uniprot id: F7HJW9
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9544:CYB5A
gene id: 9544:CYB5A
uniprot id: A0A5F8A5E6
names: Similarity
messages: Belongs to the cytochrome b5 family.

9544:SLC17A5
gene id: 9544:SLC17A5
uniprot id: A0A8J8YD47
uniprot id: F7HGP8
uniprot id: G7MPQ9
names: Subcellular Location Annotation
messages: Membrane

9544:PDK1
gene id: 9544:PDK1
uniprot id: F7GNV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:ALDH1A1
gene id: 9544:ALDH1A1
uniprot id: A0A1D5QY87
uniprot id: A0A8J8XYL5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:ACTR1B
gene id: 9544:ACTR1B
uniprot id: H9EUC6
names: Similarity
messages: Belongs to the actin family.

9544:UBE2D2
gene id: 9544:UBE2D2
uniprot id: I0FID8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:NRN1
gene id: 9544:NRN1
uniprot id: A0A5F7ZKP2
uniprot id: A0A5F8A5K0
uniprot id: A0A8J8XQE4
uniprot id: F6SIH8
names: Similarity
messages: Belongs to the neuritin family.

9544:SERP1
gene id: 9544:SERP1
uniprot id: A0A8J8Y6U6
uniprot id: F7A226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9544:GPN2
gene id: 9544:GPN2
uniprot id: A0A8J8XLZ5
uniprot id: F6YBW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9544:SPCS1
gene id: 9544:SPCS1
uniprot id: F7H6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RPL39L
gene id: 9544:RPL39L
uniprot id: F7GHP0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:MZT2B
gene id: 9544:MZT2B
uniprot id: F7FMB4
uniprot id: H9YZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9544:LYPLA2
gene id: 9544:LYPLA2
uniprot id: F7CKM3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:TTC4
gene id: 9544:TTC4
uniprot id: F6QZ42
names: Similarity
messages: Belongs to the TTC4 family.

9544:APLP2
gene id: 9544:APLP2
uniprot id: F7FJ74
uniprot id: H9FTU9
uniprot id: H9FTV0
uniprot id: I0FRD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ESYT1
gene id: 9544:ESYT1
uniprot id: A0A1D5QPB7
uniprot id: H9EVG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CAPN1
gene id: 9544:CAPN1
uniprot id: H9G0C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:CXCR1
gene id: 9544:CXCR1
uniprot id: Q2YEG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with IL8. Interacts with GNAI2.
messages: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

9544:TMEM245
gene id: 9544:TMEM245
uniprot id: A0A1D5R7V2
uniprot id: F7HG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9544:SLC25A13
gene id: 9544:SLC25A13
uniprot id: F7BR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:MIP
gene id: 9544:MIP
uniprot id: F6RG83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:CTNNB1
gene id: 9544:CTNNB1
uniprot id: F7GNE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9544:TRMU
gene id: 9544:TRMU
uniprot id: A0A5F7ZJC9
uniprot id: F6R1K4
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9544:PANX1
gene id: 9544:PANX1
uniprot id: A0A5F8A6N2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9544:JMY
gene id: 9544:JMY
uniprot id: A0A1D5R8P2
names: Subcellular Location Annotation
messages: Membrane

9544:MEPCE
gene id: 9544:MEPCE
uniprot id: H9Z0G3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9544:FADS2
gene id: 9544:FADS2
uniprot id: A0A8J8Y2M6
uniprot id: F6YUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9544:RSPO1
gene id: 9544:RSPO1
uniprot id: A0A1D5Q7L9
names: Similarity
messages: Belongs to the R-spondin family.

9544:ING4
gene id: 9544:ING4
uniprot id: A0A1D5QYV2
uniprot id: A0A1D5R9G0
uniprot id: H9FVA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:C11H12orf75
gene id: 9544:C11H12orf75
uniprot id: I0FRL4
names: Similarity
messages: Belongs to the OCC1 family.

9544:SEMA3C
gene id: 9544:SEMA3C
uniprot id: F7HNG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MVP
gene id: 9544:MVP
uniprot id: G7NQI2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9544:APEX1
gene id: 9544:APEX1
uniprot id: A0A8J8XNV0
uniprot id: F7GIK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9544:BHMT
gene id: 9544:BHMT
uniprot id: G7MUU6
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9544:TMEM178A
gene id: 9544:TMEM178A
uniprot id: H9FPY6
names: Similarity
messages: Belongs to the TMEM178 family.

9544:NXT1
gene id: 9544:NXT1
uniprot id: A0A8J8YF69
uniprot id: F6YYV6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9544:COPS5
gene id: 9544:COPS5
uniprot id: A0A8J8YIR5
uniprot id: F7H142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9544:CEBPD
gene id: 9544:CEBPD
uniprot id: F6Z8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9544:PROM1
gene id: 9544:PROM1
uniprot id: A0A5F8A3C4
uniprot id: A0A5F8AP11
uniprot id: F7DVV0
uniprot id: Q05EC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9544:INTS12
gene id: 9544:INTS12
uniprot id: A0A8J8XFG9
uniprot id: G7MTK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9544:FBLN1
gene id: 9544:FBLN1
uniprot id: A0A1D5R7Z0
uniprot id: F6PLV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:PIK3CB
gene id: 9544:PIK3CB
uniprot id: A0A8J8XK18
uniprot id: F7F3S0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:SPATA6L
gene id: 9544:SPATA6L
uniprot id: F7BE09
names: Similarity
messages: Belongs to the SPATA6 family.

9544:TMEM59
gene id: 9544:TMEM59
uniprot id: H9ZFL4
uniprot id: I0FWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:BARHL1
gene id: 9544:BARHL1
uniprot id: A0A5F8ATU3
names: Subcellular Location Annotation
messages: Nucleus

9544:EIF3F
gene id: 9544:EIF3F
uniprot id: A0A5K1VQN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9544:DUSP10
gene id: 9544:DUSP10
uniprot id: A0A8J8Y948
uniprot id: F7FRL4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:SHC1
gene id: 9544:SHC1
uniprot id: I2CUU8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TNFSF12
gene id: 9544:TNFSF12
uniprot id: H9G1A0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:KEG06 p09
gene id: 9544:KEG06_p09
uniprot id: Q6IYH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9544:NEUROD1
gene id: 9544:NEUROD1
uniprot id: A0A8J8XJ39
uniprot id: F7H950
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:ORMDL3
gene id: 9544:ORMDL3
uniprot id: A0A8J8XSJ6
uniprot id: G7NI26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9544:SLC9A2
gene id: 9544:SLC9A2
uniprot id: G7NAU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9544:ABR
gene id: 9544:ABR
uniprot id: A0A5K1UBS2
uniprot id: F6Y9W7
uniprot id: H9Z815
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9544:PABPC1
gene id: 9544:PABPC1
uniprot id: I0FGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:RPF1
gene id: 9544:RPF1
uniprot id: F6XHR5
uniprot id: H9G022
names: Subcellular Location Annotation
messages: nucleolus

9544:CTNNA2
gene id: 9544:CTNNA2
uniprot id: A0A8J8XFK0
uniprot id: F6YFG3
uniprot id: F7A9R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9544:RBFOX2
gene id: 9544:RBFOX2
uniprot id: A0A1D5Q718
uniprot id: A0A1D5R9S2
uniprot id: A0A5K1UV26
uniprot id: H9ENR7
uniprot id: H9FS71
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9544:TARS2
gene id: 9544:TARS2
uniprot id: F7H541
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9544:LDLRAD3
gene id: 9544:LDLRAD3
uniprot id: H9FQ87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:B4GAT1
gene id: 9544:B4GAT1
uniprot id: G7NC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:CNN2
gene id: 9544:CNN2
uniprot id: H9FMM8
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9544:SPTBN2
gene id: 9544:SPTBN2
uniprot id: A0A5K1UNR3
names: Similarity
messages: Belongs to the spectrin family.

9544:CAPG
gene id: 9544:CAPG
uniprot id: A0A8J8YPG0
uniprot id: G7NAI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9544:GTF2A1L
gene id: 9544:GTF2A1L
uniprot id: A0A1D5QZ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9544:OSBPL6
gene id: 9544:OSBPL6
uniprot id: A0A1D5R8B0
uniprot id: A0A8J8YL42
uniprot id: F6WMQ6
uniprot id: F6WMR4
uniprot id: F6WN07
uniprot id: G7N8E7
names: Similarity
messages: Belongs to the OSBP family.

9544:AFF1
gene id: 9544:AFF1
uniprot id: A0A1D5QFC5
uniprot id: F7CE41
names: Similarity
messages: Belongs to the AF4 family.

9544:GPR137C
gene id: 9544:GPR137C
uniprot id: F7DKY4
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9544:GADL1
gene id: 9544:GADL1
uniprot id: F6Q185
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:JAGN1
gene id: 9544:JAGN1
uniprot id: A0A8J8YCH3
uniprot id: G7MKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:MT1M
gene id: 9544:MT1M
uniprot id: A0A5F7Z894
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:GINS2
gene id: 9544:GINS2
uniprot id: F7BZU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9544:USP2
gene id: 9544:USP2
uniprot id: A0A1D5R369
uniprot id: A0A8J8XE34
uniprot id: F7DHM3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:AK6
gene id: 9544:AK6
uniprot id: H9FZ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9544:LOC703455
gene id: 9544:LOC703455
uniprot id: A0A8J8Y2T8
uniprot id: F7HQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9544:LIPJ
gene id: 9544:LIPJ
uniprot id: F7CTG9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:EED
gene id: 9544:EED
uniprot id: A0A8J8XXP1
uniprot id: F7B1B0
uniprot id: F7B1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9544:CD99L2
gene id: 9544:CD99L2
uniprot id: F6TXJ6
uniprot id: H9ZE70
names: Similarity
messages: Belongs to the CD99 family.

9544:HCFC2
gene id: 9544:HCFC2
uniprot id: F6ZF51
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC16A1
gene id: 9544:SLC16A1
uniprot id: A0A8J8XIU2
uniprot id: G7MII6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9544:MOV10
gene id: 9544:MOV10
uniprot id: A0A5F8A735
uniprot id: F6R5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9544:PRUNE1
gene id: 9544:PRUNE1
uniprot id: A0A8J8YMN8
uniprot id: F6T7I7
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9544:CPSF2
gene id: 9544:CPSF2
uniprot id: A0A8J8Y998
uniprot id: F6YTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9544:TM4SF20
gene id: 9544:TM4SF20
uniprot id: F6ZK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9544:AHDC1
gene id: 9544:AHDC1
uniprot id: F7GMF4
names: Subcellular Location Annotation
messages: Nucleus

9544:FZD4
gene id: 9544:FZD4
uniprot id: A0A1D5Q1B1
uniprot id: A0A5F8AC06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9544:SERF1A
gene id: 9544:SERF1A
uniprot id: H9EQZ3
uniprot id: H9EW76
names: Similarity
messages: Belongs to the SERF family.

9544:SPOCK2
gene id: 9544:SPOCK2
uniprot id: F6UWN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NDE1
gene id: 9544:NDE1
uniprot id: H9YZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9544:PTPRS
gene id: 9544:PTPRS
uniprot id: F7HG94
uniprot id: F7HG97
uniprot id: H9FXV0
uniprot id: I2CY17
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9544:KCNK5
gene id: 9544:KCNK5
uniprot id: G7MP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:KRT17
gene id: 9544:KRT17
uniprot id: F6YK97
names: Similarity
messages: Belongs to the intermediate filament family.

9544:PDC
gene id: 9544:PDC
uniprot id: A0A8J8XQT0
uniprot id: F7EQ61
names: Similarity
messages: Belongs to the phosducin family.

9544:EXOC6
gene id: 9544:EXOC6
uniprot id: F7FZN9
uniprot id: F7FZP8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:GNAT1
gene id: 9544:GNAT1
uniprot id: A0A8J8Y794
uniprot id: F7GK45
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:CDC42EP2
gene id: 9544:CDC42EP2
uniprot id: A0A8J8XHU7
uniprot id: F7DGL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9544:KRT73
gene id: 9544:KRT73
uniprot id: F7AEN7
names: Similarity
messages: Belongs to the intermediate filament family.

9544:C8H8orf82
gene id: 9544:C8H8orf82
uniprot id: F6XB79
names: Similarity
messages: Belongs to the UPF0598 family.

9544:PHC3
gene id: 9544:PHC3
uniprot id: A0A1D5QB94
uniprot id: A0A5F7ZWX2
uniprot id: G7MJB4
uniprot id: H9ZDR9
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC695668
gene id: 9544:LOC695668
uniprot id: G7MGD8
names: Subcellular Location Annotation
messages: Membrane

9544:CFDP1
gene id: 9544:CFDP1
uniprot id: H9YZP3
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9544:TEKT5
gene id: 9544:TEKT5
uniprot id: F7B647
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9544:CREM
gene id: 9544:CREM
uniprot id: F6YPU2
names: Subcellular Location Annotation
messages: Nucleus

9544:PATZ1
gene id: 9544:PATZ1
uniprot id: H9FS89
names: Subcellular Location Annotation
messages: Nucleus

9544:SPESP1
gene id: 9544:SPESP1
uniprot id: F6TNB6
names: Function
names: Similarity
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.

9544:TRIM46
gene id: 9544:TRIM46
uniprot id: F6TTN4
names: Subcellular Location Annotation
messages: cytoskeleton

9544:TSSK6
gene id: 9544:TSSK6
uniprot id: A0A8J8Y220
uniprot id: G7NNH2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:SLC12A5
gene id: 9544:SLC12A5
uniprot id: H9EUB3
uniprot id: I2CUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:FCER1G
gene id: 9544:FCER1G
uniprot id: F6SD41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9544:PSMC3IP
gene id: 9544:PSMC3IP
uniprot id: A0A8J8XKG4
uniprot id: G7NIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9544:LAPTM4A
gene id: 9544:LAPTM4A
uniprot id: A0A8J8YC21
uniprot id: F7GV77
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9544:FAM155A
gene id: 9544:FAM155A
uniprot id: F7HHG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9544:NAA35
gene id: 9544:NAA35
uniprot id: F7FX53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9544:TRPC4
gene id: 9544:TRPC4
uniprot id: A0A1D5QA06
names: Subcellular Location Annotation
messages: Membrane

9544:SUV39H1
gene id: 9544:SUV39H1
uniprot id: A0A8J8XR04
uniprot id: F6X1Z9
uniprot id: F7APZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9544:PTER
gene id: 9544:PTER
uniprot id: A0A8J8YB78
uniprot id: G7N1N3
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MGAT1
gene id: 9544:MGAT1
uniprot id: A0A8J8YLX1
uniprot id: G7MUK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9544:GFM2
gene id: 9544:GFM2
uniprot id: F7FNF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9544:SLC39A11
gene id: 9544:SLC39A11
uniprot id: H9FR09
names: Subcellular Location Annotation
messages: Membrane

9544:NTF3
gene id: 9544:NTF3
uniprot id: A0A1D5Q655
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9544:DOP1A
gene id: 9544:DOP1A
uniprot id: A0A8J8YMN7
uniprot id: G7MPT4
names: Similarity
messages: Belongs to the dopey family.

9544:OXSM
gene id: 9544:OXSM
uniprot id: F6W670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9544:EFNA3
gene id: 9544:EFNA3
uniprot id: A0A1D5QCP5
uniprot id: I2CYI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ANO10
gene id: 9544:ANO10
uniprot id: F7D1X4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:QPCTL
gene id: 9544:QPCTL
uniprot id: F7E1J2
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9544:ALG5
gene id: 9544:ALG5
uniprot id: A0A8J8YDE1
uniprot id: F7EN62
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9544:MS4A7
gene id: 9544:MS4A7
uniprot id: F6QJM7
names: Similarity
messages: Belongs to the MS4A family.

9544:NDUFAF4
gene id: 9544:NDUFAF4
uniprot id: A0A5F7ZMH3
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9544:SESN1
gene id: 9544:SESN1
uniprot id: A0A8J8Y4R1
uniprot id: F7D7D8
uniprot id: F7E0H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9544:PSMA5
gene id: 9544:PSMA5
uniprot id: A0A8J8Y2U9
uniprot id: I0FTI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:SEMA4G
gene id: 9544:SEMA4G
uniprot id: F7AXD7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SEPTIN11
gene id: 9544:SEPTIN11
uniprot id: A0A1D5QBP6
uniprot id: A0A1D5QDX5
uniprot id: A0A5F7ZQN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:EMC3
gene id: 9544:EMC3
uniprot id: A0A8J8XW38
uniprot id: G7MKR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9544:INO80C
gene id: 9544:INO80C
uniprot id: A0A1D5Q9X9
uniprot id: F7GKL1
names: Subcellular Location Annotation
messages: Nucleus

9544:CCL3
gene id: 9544:CCL3
uniprot id: Q8HYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity).
messages: Secreted
messages: Self-associates.

9544:COPS7B
gene id: 9544:COPS7B
uniprot id: A0A8J8Y4J8
uniprot id: F6T991
uniprot id: F6UMP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9544:MPP1
gene id: 9544:MPP1
uniprot id: A0A8J8YJM2
uniprot id: F6W130
uniprot id: F6W1C9
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9544:RAB18
gene id: 9544:RAB18
uniprot id: A0A1D5RB55
uniprot id: F7EUM0
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9544:FAM49A
gene id: 9544:FAM49A
uniprot id: A0A8J8Y8L7
uniprot id: F6UFH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9544:ARF6
gene id: 9544:ARF6
uniprot id: A0A8J8XVI5
uniprot id: F6RLV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9544:MYO1D
gene id: 9544:MYO1D
uniprot id: F7GTU3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:LOC711318
gene id: 9544:LOC711318
uniprot id: F6SGN0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9544:SMG1
gene id: 9544:SMG1
uniprot id: A0A5F7ZLC3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9544:ZDHHC7
gene id: 9544:ZDHHC7
uniprot id: H9EMM2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:PMM2
gene id: 9544:PMM2
uniprot id: A0A1D5QBK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9544:FOLR1
gene id: 9544:FOLR1
uniprot id: A0A8J8XQJ3
uniprot id: F7BP60
names: Similarity
messages: Belongs to the folate receptor family.

9544:PRKAB1
gene id: 9544:PRKAB1
uniprot id: A0A8J8XAB8
uniprot id: H9EPL6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9544:FAIM2
gene id: 9544:FAIM2
uniprot id: A0A5K1UI87
uniprot id: H9Z6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:MAPK14
gene id: 9544:MAPK14
uniprot id: A0A8J8XDA7
uniprot id: F6V370
uniprot id: G7MRU1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9544:NAP1L2
gene id: 9544:NAP1L2
uniprot id: F6UCS3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:POLR2M
gene id: 9544:POLR2M
uniprot id: F7DXR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9544:CCR9
gene id: 9544:CCR9
uniprot id: A0A8J8XHJ5
uniprot id: F7HFQ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SLC25A32
gene id: 9544:SLC25A32
uniprot id: A0A8J8YL30
uniprot id: H9YZI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:PPP2R3C
gene id: 9544:PPP2R3C
uniprot id: A0A8J8XZ50
uniprot id: G7MXG3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:ACTR3B
gene id: 9544:ACTR3B
uniprot id: A0A1D5RDF9
uniprot id: F7H2T8
names: Similarity
messages: Belongs to the actin family.

9544:KLC1
gene id: 9544:KLC1
uniprot id: A0A5K1U6B2
uniprot id: F6R4Z4
uniprot id: H9EMP0
uniprot id: H9EMP1
uniprot id: H9EMP2
uniprot id: H9FU76
uniprot id: H9FU77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9544:RRM2
gene id: 9544:RRM2
uniprot id: F6WXL4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9544:DYNLT1
gene id: 9544:DYNLT1
uniprot id: A0A8J8XVU0
uniprot id: F6QZS9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9544:INSM2
gene id: 9544:INSM2
uniprot id: F7G7V4
names: Subcellular Location Annotation
messages: Nucleus

9544:RPL38
gene id: 9544:RPL38
uniprot id: G7NGL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9544:GDF5
gene id: 9544:GDF5
uniprot id: F7EE07
names: Similarity
messages: Belongs to the TGF-beta family.

9544:AKAP5
gene id: 9544:AKAP5
uniprot id: A0A1D5QW76
names: Subcellular Location Annotation
messages: Membrane

9544:OR51G2
gene id: 9544:OR51G2
uniprot id: A0A5F8AB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:USP33
gene id: 9544:USP33
uniprot id: A0A5K1USX4
uniprot id: F7HF92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9544:DPRX
gene id: 9544:DPRX
uniprot id: A0A5F8A7A2
names: Subcellular Location Annotation
messages: Nucleus

9544:EEF1G
gene id: 9544:EEF1G
uniprot id: F7HML3
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9544:SART1
gene id: 9544:SART1
uniprot id: H9G1L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9544:BGN
gene id: 9544:BGN
uniprot id: A0A8J8XNS5
uniprot id: G7NSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9544:PROS1
gene id: 9544:PROS1
uniprot id: F6WG91
uniprot id: Q28520
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasma.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9544:GANAB
gene id: 9544:GANAB
uniprot id: A0A8J8YKQ6
uniprot id: G7NCT6
uniprot id: I0FJQ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9544:PSKH1
gene id: 9544:PSKH1
uniprot id: A0A8J8Y0K8
uniprot id: F7HN09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:AHCY
gene id: 9544:AHCY
uniprot id: H9ES33
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9544:ACSL4
gene id: 9544:ACSL4
uniprot id: A0A5F8A496
uniprot id: A0A8J8YQC9
uniprot id: F6Z9U8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:ATOH7
gene id: 9544:ATOH7
uniprot id: F6ULQ5
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9544:TFB1M
gene id: 9544:TFB1M
uniprot id: A0A8J8XTG9
uniprot id: G7MQ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9544:NKX2-1
gene id: 9544:NKX2-1
uniprot id: A0A5F8ASM6
uniprot id: F6YQK0
names: Subcellular Location Annotation
messages: Nucleus

9544:CCNJ
gene id: 9544:CCNJ
uniprot id: A0A8J8YDJ2
uniprot id: G7N2M7
names: Similarity
messages: Belongs to the cyclin family.

9544:RPL27
gene id: 9544:RPL27
uniprot id: F7GZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9544:ACER3
gene id: 9544:ACER3
uniprot id: F7EYF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9544:PPM1G
gene id: 9544:PPM1G
uniprot id: F7H941
names: Similarity
messages: Belongs to the PP2C family.

9544:PHYKPL
gene id: 9544:PHYKPL
uniprot id: H9EWC7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:ISCA2
gene id: 9544:ISCA2
uniprot id: H9EW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9544:AGT
gene id: 9544:AGT
uniprot id: G7MFR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9544:ZFHX3
gene id: 9544:ZFHX3
uniprot id: A0A5F7ZI76
names: Subcellular Location Annotation
messages: Nucleus

9544:ZNF532
gene id: 9544:ZNF532
uniprot id: F7D3P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:TUBGCP4
gene id: 9544:TUBGCP4
uniprot id: A0A1D5R0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9544:CBL
gene id: 9544:CBL
uniprot id: A0A1D5RFE7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9544:GTF2A2
gene id: 9544:GTF2A2
uniprot id: A0A1D5QF26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9544:CXCL9
gene id: 9544:CXCL9
uniprot id: Q8MIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:TCP11
gene id: 9544:TCP11
uniprot id: A0A1D5Q379
uniprot id: A0A8J8XY12
uniprot id: F7E782
names: Similarity
messages: Belongs to the TCP11 family.

9544:UCN
gene id: 9544:UCN
uniprot id: I2CUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9544:RENBP
gene id: 9544:RENBP
uniprot id: F6YUM9
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9544:RPS21
gene id: 9544:RPS21
uniprot id: F7AM94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9544:LDHB
gene id: 9544:LDHB
uniprot id: F7HQ10
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9544:MAP3K15
gene id: 9544:MAP3K15
uniprot id: A0A5F7ZNK0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9544:EEF1A1
gene id: 9544:EEF1A1
uniprot id: F7AW94
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9544:MINPP1
gene id: 9544:MINPP1
uniprot id: F6SM55
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9544:LOC713572
gene id: 9544:LOC713572
uniprot id: A0A8J8XSN5
uniprot id: G7MX43
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:MFF
gene id: 9544:MFF
uniprot id: A0A5F7ZEV4
uniprot id: A0A5F7ZRM2
uniprot id: A0A5F8AHI1
uniprot id: F6ZK26
uniprot id: F6ZK35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9544:SLC7A5
gene id: 9544:SLC7A5
uniprot id: H9ZDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9544:TDRD3
gene id: 9544:TDRD3
uniprot id: A0A5F8AN96
uniprot id: G7NK75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Cytoplasm
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9544:CPXM2
gene id: 9544:CPXM2
uniprot id: F6W9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9544:TRIM23
gene id: 9544:TRIM23
uniprot id: A0A8J8XSF8
uniprot id: F7GEV6
names: Subcellular Location Annotation
messages: Nucleus

9544:SFTPA1
gene id: 9544:SFTPA1
uniprot id: Q9TUC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Secreted
messages: extracellular matrix
messages: surface film

9544:SLC2A13
gene id: 9544:SLC2A13
uniprot id: F6T0L4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9544:NOL11
gene id: 9544:NOL11
uniprot id: H9FSM3
names: Subcellular Location Annotation
messages: nucleolus

9544:LYNX1
gene id: 9544:LYNX1
uniprot id: A0A5F7ZL24
uniprot id: P0DP62
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life.
messages: Cell membrane
messages: Detected as early as day 71 of gestation. Expression increases consistently in lungs throughout the prenatal period. After birth, expression continues well into adulthood. At 71 days of gestation (pseudoglandular phase), expression is detected in tracheal and proximal conducting airway epithelium. Expression decreases gradually toward the distal airways. Strong expression in the epithelium lining the tips of the dichotomous and monopodial airway buds. Weakly expressed in smooth muscle cells around the large airways. Weakly expressed in mesenchymal cells and not at all in the mesenchymal cells surrounding the airway buds. Not detected in vessels associated with large airways (at protein level). At 94 days of gestation, similar expression pattern, but expression increases and extends toward distal airway epithelium. Strong expression in type II cells that line the primitive air spaces of late canalicular and early saccular phase. More prominent expression in the smooth muscle cells surrounding the large airways. Begins to be weakly expressed in endothelial and smooth muscle cells in large vessels, but not in small distal vessels (at protein level). At day 134 of gestation, further increase in expression in the distal airway epithelium. In large airways, predominantly expressed in the ciliated epithelium. Expressed at low levels in the mucus-secreting cells and at high levels in the submucosal gland cells. Weakly expressed in paracartilaginous cells, but not in cells in the extra-cartilaginous layer. Not detected in type I alveolar cells. Strongly expressed in endothelial and smooth muscle cells increased in large vessels and in distal vessels (at protein level). At birth, similar pattern of expression. Slightly decreased expression in the proximal airways (at protein level).
messages: Endoplasmic reticulum
messages: Expressed in lung predominantly in airway epithelial cells, submucous glands, and smooth muscle cells, in endothelial and smooth muscle cells in vessel walls and in alveolar type II cells (at protein level). Also expressed in brain.
messages: Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits. Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly.
messages: Membrane
messages: Up-regulated by prenatal nicotine exposure.
messages: dendrite

9544:HK1
gene id: 9544:HK1
uniprot id: H9FTP9
names: Similarity
messages: Belongs to the hexokinase family.

9544:DAD1
gene id: 9544:DAD1
uniprot id: A0A8J8XL02
uniprot id: G7MX20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:TNFRSF1A
gene id: 9544:TNFRSF1A
uniprot id: A0A8J8XFE9
uniprot id: G7N5L8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:LOC701497
gene id: 9544:LOC701497
uniprot id: F7HRX4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9544:FKBP4
gene id: 9544:FKBP4
uniprot id: H9ERN7
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Nucleus
messages: cytoskeleton
messages: cytosol

9544:TLR4
gene id: 9544:TLR4
uniprot id: A0A8J8XMT1
uniprot id: B3Y632
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:SIAH1
gene id: 9544:SIAH1
uniprot id: A0A5F7ZGZ6
uniprot id: A0A8J8YH02
uniprot id: F6T3K3
uniprot id: F6WEY4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9544:XKR8
gene id: 9544:XKR8
uniprot id: A0A5F8AN23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9544:ENPP2
gene id: 9544:ENPP2
uniprot id: G7N009
uniprot id: I0FJB5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9544:LOC717517
gene id: 9544:LOC717517
uniprot id: A0A5F7ZJF7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9544:GLRA1
gene id: 9544:GLRA1
uniprot id: A0A5K1V9F3
uniprot id: F7GTN8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9544:PPP2R5C
gene id: 9544:PPP2R5C
uniprot id: A0A5K1VS24
uniprot id: F7ANY1
uniprot id: H9FWN6
uniprot id: I0FIN3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:YOD1
gene id: 9544:YOD1
uniprot id: F6XIA9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9544:TMCO4
gene id: 9544:TMCO4
uniprot id: F7FSJ1
names: Similarity
messages: Belongs to the TMCO4 family.

9544:FAM53C
gene id: 9544:FAM53C
uniprot id: A0A8J8YLN2
uniprot id: F7GUH5
names: Similarity
messages: Belongs to the FAM53 family.

9544:SBNO1
gene id: 9544:SBNO1
uniprot id: G7N694
uniprot id: I0FT20
names: Similarity
messages: Belongs to the SBNO family.

9544:MED29
gene id: 9544:MED29
uniprot id: H9FWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9544:TAZ
gene id: 9544:TAZ
uniprot id: F7FYK4
uniprot id: Q6IV77
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). RCL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, …
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: The HXXXXD motif is essential for acyltransferase activity.
messages: The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization.

9544:POLR3F
gene id: 9544:POLR3F
uniprot id: A0A8J8XI16
uniprot id: G7N320
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:PRIM1
gene id: 9544:PRIM1
uniprot id: A0A8J8XK04
uniprot id: G7N7D9
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9544:CSGALNACT2
gene id: 9544:CSGALNACT2
uniprot id: H9ESV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:ATP6V1D
gene id: 9544:ATP6V1D
uniprot id: A0A8J8Y835
uniprot id: F7EFE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9544:VSIG1
gene id: 9544:VSIG1
uniprot id: A0A8J8YEL7
uniprot id: F7EVD7
names: Subcellular Location Annotation
messages: Membrane

9544:GALM
gene id: 9544:GALM
uniprot id: F7GQT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9544:HSPB8
gene id: 9544:HSPB8
uniprot id: Q6SJQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity).
messages: Nucleus
messages: Phosphorylated.

9544:NR1H4
gene id: 9544:NR1H4
uniprot id: F6U1W4
uniprot id: F7ETB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:GLE1
gene id: 9544:GLE1
uniprot id: A0A1D5QE51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9544:MCPH1
gene id: 9544:MCPH1
uniprot id: J7JV15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9544:HOXA10
gene id: 9544:HOXA10
uniprot id: F6YAI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:LAMTOR4
gene id: 9544:LAMTOR4
uniprot id: H9FUA4
names: Similarity
messages: Belongs to the LAMTOR4 family.

9544:PIK3IP1
gene id: 9544:PIK3IP1
uniprot id: A0A5F8ADS8
uniprot id: F7CNM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:FAM122B
gene id: 9544:FAM122B
uniprot id: A0A8J8YEM5
uniprot id: G7NRM3
uniprot id: H9FQJ6
uniprot id: H9FQJ7
uniprot id: H9Z5R6
uniprot id: H9Z5R7
uniprot id: H9Z5R8
names: Similarity
messages: Belongs to the FAM122 family.

9544:TOB1
gene id: 9544:TOB1
uniprot id: A0A8J8XZV8
uniprot id: F7GFK0
names: Similarity
messages: Belongs to the BTG family.

9544:CNIH1
gene id: 9544:CNIH1
uniprot id: A0A1D5QEI7
uniprot id: F7FI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:AGO4
gene id: 9544:AGO4
uniprot id: H9Z624
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9544:RAD21
gene id: 9544:RAD21
uniprot id: H9EMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9544:ALDH1B1
gene id: 9544:ALDH1B1
uniprot id: F7H5N9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:ILK
gene id: 9544:ILK
uniprot id: A0A8J8YHP8
uniprot id: F7C2W0
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9544:RPS6KA3
gene id: 9544:RPS6KA3
uniprot id: F7B501
uniprot id: H9ZC41
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:CCHCR1
gene id: 9544:CCHCR1
uniprot id: Q5TM47
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9544:IL23A
gene id: 9544:IL23A
uniprot id: A0A8J8XF71
uniprot id: F7HQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9544:ATP1A1
gene id: 9544:ATP1A1
uniprot id: F6WKJ2
uniprot id: F7HE86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9544:YARS2
gene id: 9544:YARS2
uniprot id: H9H3M7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:CYP26A1
gene id: 9544:CYP26A1
uniprot id: F7FWJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:MC4R
gene id: 9544:MC4R
uniprot id: A0A8J8XAD5
uniprot id: F7GYJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9544:ELOVL4
gene id: 9544:ELOVL4
uniprot id: A0A8J8XYA6
uniprot id: G7MPS8
uniprot id: Q3S8M4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: N-glycosylated.
messages: Oligomer.
messages: The C-terminal di-lysine motif confers endoplasmic reticulum localization.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9544:ACD
gene id: 9544:ACD
uniprot id: F6XSB4
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9544:TMEM176A
gene id: 9544:TMEM176A
uniprot id: H9FWS6
names: Similarity
messages: Belongs to the TMEM176 family.

9544:SEC61B
gene id: 9544:SEC61B
uniprot id: F7B5P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9544:EXT1
gene id: 9544:EXT1
uniprot id: A0A8J8XGU3
uniprot id: F7F8Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

9544:TLR7
gene id: 9544:TLR7
uniprot id: B3Y653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:RIC8B
gene id: 9544:RIC8B
uniprot id: A0A5F8ASZ2
uniprot id: A0A8J8YNX6
uniprot id: F7H8I7
uniprot id: G7N5D4
uniprot id: H9FWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9544:ADAMTS14
gene id: 9544:ADAMTS14
uniprot id: F7FHT3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:MFRP
gene id: 9544:MFRP
uniprot id: G7NCK8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:POLA2
gene id: 9544:POLA2
uniprot id: A0A5F7ZU29
uniprot id: F7HTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9544:SCAMP5
gene id: 9544:SCAMP5
uniprot id: I0FHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:SLC14A2
gene id: 9544:SLC14A2
uniprot id: F6XQB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9544:TCF19
gene id: 9544:TCF19
uniprot id: Q5TM48
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

9544:NLRP9
gene id: 9544:NLRP9
uniprot id: B0FNA9
names: Similarity
messages: Belongs to the NLRP family.

9544:CHRNB2
gene id: 9544:CHRNB2
uniprot id: F7GMZ4
uniprot id: I2CTM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:FAM3B
gene id: 9544:FAM3B
uniprot id: F6YNL3
uniprot id: F6YP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9544:ARL14
gene id: 9544:ARL14
uniprot id: G7MJD9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:TAF2
gene id: 9544:TAF2
uniprot id: H9EU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9544:NUDT21
gene id: 9544:NUDT21
uniprot id: A0A8J8XJI4
uniprot id: G7NPC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9544:PCID2
gene id: 9544:PCID2
uniprot id: H9EUI7
names: Similarity
messages: Belongs to the CSN12 family.

9544:CDK2AP2
gene id: 9544:CDK2AP2
uniprot id: A0A8J8YPI3
uniprot id: F7H786
names: Similarity
messages: Belongs to the CDK2AP family.

9544:IMMT
gene id: 9544:IMMT
uniprot id: H9ESC3
uniprot id: H9ESD6
uniprot id: H9Z4P3
uniprot id: I0FNS7
uniprot id: I0FNS8
uniprot id: I0FNS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9544:C8G
gene id: 9544:C8G
uniprot id: F7GRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9544:SDR42E1
gene id: 9544:SDR42E1
uniprot id: F6UMT9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9544:SYBU
gene id: 9544:SYBU
uniprot id: A0A5F8A9Z0
uniprot id: A0A5K1VA47
uniprot id: F6YA82
names: Subcellular Location Annotation
messages: Membrane

9544:EPS8L2
gene id: 9544:EPS8L2
uniprot id: F6VIA6
names: Similarity
messages: Belongs to the EPS8 family.

9544:CFHR2
gene id: 9544:CFHR2
uniprot id: G7MF05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:EPC1
gene id: 9544:EPC1
uniprot id: A0A1D5QR41
uniprot id: A0A5K1UQ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9544:SCRN3
gene id: 9544:SCRN3
uniprot id: A0A1D5QHT0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9544:PRKACB
gene id: 9544:PRKACB
uniprot id: A0A1D5QFQ7
uniprot id: A0A1D5RCW7
uniprot id: A0A5K1UDP0
uniprot id: F7EBR0
uniprot id: F7EBR5
uniprot id: H9FWY1
uniprot id: H9FWY2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9544:DTNA
gene id: 9544:DTNA
uniprot id: F7ELC4
uniprot id: I0FPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9544:ALDH3A2
gene id: 9544:ALDH3A2
uniprot id: A0A1D5QV70
uniprot id: F7C1B5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:TIMM17A
gene id: 9544:TIMM17A
uniprot id: A0A8J8XM01
uniprot id: F6TZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9544:BOD1
gene id: 9544:BOD1
uniprot id: F6TDI5
uniprot id: H9EQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9544:SELE
gene id: 9544:SELE
uniprot id: A0A1D5QPQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MCU
gene id: 9544:MCU
uniprot id: F6U7W6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9544:DCTN2
gene id: 9544:DCTN2
uniprot id: F6UW67
uniprot id: H9FNS4
uniprot id: H9FNS5
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9544:TRABD2A
gene id: 9544:TRABD2A
uniprot id: A0A8J8YA05
uniprot id: G7NAH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9544:AQP10
gene id: 9544:AQP10
uniprot id: H9H4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:TMED7
gene id: 9544:TMED7
uniprot id: H9ESZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:FOXD2
gene id: 9544:FOXD2
uniprot id: F6YN08
names: Subcellular Location Annotation
messages: Nucleus

9544:ARF1
gene id: 9544:ARF1
uniprot id: F7H235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9544:ANXA11
gene id: 9544:ANXA11
uniprot id: H9FTQ4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:HDAC4
gene id: 9544:HDAC4
uniprot id: F6VW34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9544:PPIL3
gene id: 9544:PPIL3
uniprot id: H9ERV3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:SBDS
gene id: 9544:SBDS
uniprot id: A0A8J8YHG6
uniprot id: G7MP28
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9544:TSC22D2
gene id: 9544:TSC22D2
uniprot id: A0A5F7ZVL3
uniprot id: A0A8J8XVC1
uniprot id: G7MJI6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9544:BAZ1B
gene id: 9544:BAZ1B
uniprot id: A0A5F8A4T7
names: Subcellular Location Annotation
messages: Nucleus

9544:BRI3
gene id: 9544:BRI3
uniprot id: A0A1D5QG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

9544:LEPROT
gene id: 9544:LEPROT
uniprot id: H9FW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9544:ELAVL2
gene id: 9544:ELAVL2
uniprot id: F6TG57
uniprot id: H9ENU4
uniprot id: I0FPT1
names: Similarity
messages: Belongs to the RRM elav family.

9544:VASN
gene id: 9544:VASN
uniprot id: I0FP13
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GSTCD
gene id: 9544:GSTCD
uniprot id: A0A8J8XU01
uniprot id: F6ZHH4
names: Similarity
messages: Belongs to the GSTCD family.

9544:NAA40
gene id: 9544:NAA40
uniprot id: H9FZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9544:C13H2orf49
gene id: 9544:C13H2orf49
uniprot id: A0A5F8AKU4
uniprot id: A0A8J8YJ66
uniprot id: F6V435
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9544:NR4A2
gene id: 9544:NR4A2
uniprot id: A0A8J8Y407
uniprot id: G7N845
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9544:CYP3A4
gene id: 9544:CYP3A4
uniprot id: Q6PSM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:ANKRD34B
gene id: 9544:ANKRD34B
uniprot id: A0A8J8XDJ2
uniprot id: F6QSM6
names: Similarity
messages: Belongs to the ANKRD34 family.

9544:TOM1
gene id: 9544:TOM1
uniprot id: I0FGD9
names: Similarity
messages: Belongs to the TOM1 family.

9544:DDX52
gene id: 9544:DDX52
uniprot id: A0A5F8A253
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9544:APMAP
gene id: 9544:APMAP
uniprot id: A0A8J8XRN0
uniprot id: G7N355
names: Similarity
messages: Belongs to the strictosidine synthase family.

9544:VPS54
gene id: 9544:VPS54
uniprot id: F7DKK9
uniprot id: H9Z205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9544:KIAA1191
gene id: 9544:KIAA1191
uniprot id: A0A1D5QAK4
uniprot id: A0A1D5R638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9544:GPAM
gene id: 9544:GPAM
uniprot id: A0A5K1UAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9544:UBA6
gene id: 9544:UBA6
uniprot id: H9FWM4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9544:CCT7
gene id: 9544:CCT7
uniprot id: F6XZH8
uniprot id: I2CXZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9544:PSEN2
gene id: 9544:PSEN2
uniprot id: F7A2D1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9544:OTUB2
gene id: 9544:OTUB2
uniprot id: A0A5F7ZPC2
names: Similarity
messages: Belongs to the peptidase C65 family.

9544:PHB
gene id: 9544:PHB
uniprot id: F7HLX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9544:CCDC181
gene id: 9544:CCDC181
uniprot id: A0A5F7ZBE6
uniprot id: I2CXE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9544:YIPF2
gene id: 9544:YIPF2
uniprot id: A0A5F7ZYC7
uniprot id: H9ZDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9544:OR4N2
gene id: 9544:OR4N2
uniprot id: F6U4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:DGKZ
gene id: 9544:DGKZ
uniprot id: A0A1D5R745
uniprot id: A0A1D5RBV3
uniprot id: H9G116
uniprot id: I2CU98
uniprot id: I2CUS8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:UBE2T
gene id: 9544:UBE2T
uniprot id: H9EWW6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:MRPL41
gene id: 9544:MRPL41
uniprot id: H9ZCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9544:TMEM30A
gene id: 9544:TMEM30A
uniprot id: A0A8J8Y1J6
uniprot id: I0FTB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

9544:GRHPR
gene id: 9544:GRHPR
uniprot id: H9G201
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9544:DNAH1
gene id: 9544:DNAH1
uniprot id: F7AZV1
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:ST3GAL5
gene id: 9544:ST3GAL5
uniprot id: F7A1D7
uniprot id: F7CKA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:DERL1
gene id: 9544:DERL1
uniprot id: A0A8J8XMZ5
uniprot id: F6Z7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9544:TCTN2
gene id: 9544:TCTN2
uniprot id: I0FMS5
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9544:TRIM17
gene id: 9544:TRIM17
uniprot id: F7GJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9544:PIGU
gene id: 9544:PIGU
uniprot id: F6UA81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RPS27
gene id: 9544:RPS27
uniprot id: H9H3Z7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9544:ACTL6B
gene id: 9544:ACTL6B
uniprot id: A0A8J8YH38
uniprot id: G7MNV3
names: Similarity
messages: Belongs to the actin family.

9544:PPARG
gene id: 9544:PPARG
uniprot id: O18924
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Highest expression in adipose tissue. Lower in liver, heart, kidney, stomach, duodenum and colon.
messages: Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4. Interacts (when in the liganded conformation) with GPS2 (By similarity). Interacts with CRY1 and CRY2 in a ligand-dependent manner (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
messages: Nucleus
messages: O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.
messages: PDPK1 activates its transcriptional activity independently of its kinase activity.
messages: Phosphorylated at basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation induces adipogenic activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9544:REEP3
gene id: 9544:REEP3
uniprot id: H9Z1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9544:TRMT2B
gene id: 9544:TRMT2B
uniprot id: F6UTK6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:AGBL5
gene id: 9544:AGBL5
uniprot id: A0A8J8XWS0
uniprot id: G7N9M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9544:CBX2
gene id: 9544:CBX2
uniprot id: I0FVS0
names: Subcellular Location Annotation
messages: Nucleus

9544:NLE1
gene id: 9544:NLE1
uniprot id: A0A1D5R0W2
names: Subcellular Location Annotation
messages: nucleolus

9544:HDHD3
gene id: 9544:HDHD3
uniprot id: A0A8J8YQP3
uniprot id: F7GY57
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:HINT1
gene id: 9544:HINT1
uniprot id: F6R248
names: Similarity
messages: Belongs to the HINT family.

9544:TMEM19
gene id: 9544:TMEM19
uniprot id: A0A8J8YJT8
uniprot id: H9YVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9544:RSBN1L
gene id: 9544:RSBN1L
uniprot id: H9FRB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9544:CPT1B
gene id: 9544:CPT1B
uniprot id: A0A8J8Y931
uniprot id: G7N4F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:HNRNPUL2
gene id: 9544:HNRNPUL2
uniprot id: I0FIH2
names: Subcellular Location Annotation
messages: Nucleus

9544:AURKB
gene id: 9544:AURKB
uniprot id: A0A8J8Y9R5
uniprot id: F6VVA5
uniprot id: G7NIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9544:RPL34
gene id: 9544:RPL34
uniprot id: A0A8J8YRI1
uniprot id: F7DWL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9544:GABARAP
gene id: 9544:GABARAP
uniprot id: F6U6S1
names: Similarity
messages: Belongs to the ATG8 family.

9544:CDH7
gene id: 9544:CDH7
uniprot id: F6ZW11
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:MTRF1
gene id: 9544:MTRF1
uniprot id: A0A8J8Y198
uniprot id: F7DST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9544:UBE2H
gene id: 9544:UBE2H
uniprot id: A0A8J8XQZ5
uniprot id: G7MMC6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:TTC26
gene id: 9544:TTC26
uniprot id: A0A1D5Q9K7
names: Similarity
messages: Belongs to the IFT56 family.

9544:CLRN2
gene id: 9544:CLRN2
uniprot id: F6TQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9544:PELO
gene id: 9544:PELO
uniprot id: F7GLR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

9544:PFDN4
gene id: 9544:PFDN4
uniprot id: A0A1D5RGY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9544:TMEM50A
gene id: 9544:TMEM50A
uniprot id: A0A8J8Y2T3
uniprot id: F7FZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9544:NAIF1
gene id: 9544:NAIF1
uniprot id: F6RU55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9544:VPS26A
gene id: 9544:VPS26A
uniprot id: H9EPD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9544:IFNA13
gene id: 9544:IFNA13
uniprot id: A0A5F8AJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:DPM2
gene id: 9544:DPM2
uniprot id: H9EXG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9544:SLC2A5
gene id: 9544:SLC2A5
uniprot id: A0A1D5QWB5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: sarcolemma

9544:MYO6
gene id: 9544:MYO6
uniprot id: A0A1D5QGD8
uniprot id: A7XBL5
uniprot id: F7ARX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus

9544:ARG2
gene id: 9544:ARG2
uniprot id: A0A8J8YPX4
uniprot id: F7C244
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9544:FOXO1
gene id: 9544:FOXO1
uniprot id: F6ZVZ0
names: Subcellular Location Annotation
messages: Nucleus

9544:APLN
gene id: 9544:APLN
uniprot id: F7GX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

9544:PHTF1
gene id: 9544:PHTF1
uniprot id: F7H7M2
uniprot id: G7MII9
names: Subcellular Location Annotation
messages: Membrane

9544:ELK3
gene id: 9544:ELK3
uniprot id: A0A8J8XJB0
uniprot id: F7F772
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:KAT7
gene id: 9544:KAT7
uniprot id: A0A1D5QUW5
uniprot id: H9ENC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9544:RPP21
gene id: 9544:RPP21
uniprot id: Q5TM57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA.
messages: nucleolus

9544:OR5AP2
gene id: 9544:OR5AP2
uniprot id: F6WZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LSM2
gene id: 9544:LSM2
uniprot id: A0A8J8Y5X4
uniprot id: G7MRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9544:NASP
gene id: 9544:NASP
uniprot id: H9EW48
uniprot id: H9FUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9544:KCNN3
gene id: 9544:KCNN3
uniprot id: F7ETY4
names: Subcellular Location Annotation
messages: Membrane

9544:NAP1L1
gene id: 9544:NAP1L1
uniprot id: F7BMC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:ANK3
gene id: 9544:ANK3
uniprot id: I0FR20
names: Subcellular Location Annotation
messages: Membrane

9544:MRPS17
gene id: 9544:MRPS17
uniprot id: A0A1D5Q4H5
uniprot id: A0A8J8YM43
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9544:ATP6V1E2
gene id: 9544:ATP6V1E2
uniprot id: A0A8J8Y8R9
uniprot id: F7GUI3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9544:CNR1
gene id: 9544:CNR1
uniprot id: A0A8J8Y3J7
uniprot id: G7MPW5
uniprot id: Q71SP5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity).…
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Hemopressin, a peptide derived from hemoglobin subunit alpha (HBA1 and/or HBA2), acts as an antagonist peptide: hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (By similarity). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane
messages: Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.
messages: Presynapse
messages: Synapse
messages: axon

9544:MTFP1
gene id: 9544:MTFP1
uniprot id: A0A8J8YIY0
uniprot id: G7N3L0
names: Similarity
messages: Belongs to the MTFP1 family.

9544:VKORC1L1
gene id: 9544:VKORC1L1
uniprot id: A0A1D5Q1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:HKDC1
gene id: 9544:HKDC1
uniprot id: F7HAC6
names: Similarity
messages: Belongs to the hexokinase family.

9544:DPF1
gene id: 9544:DPF1
uniprot id: F6XFX0
uniprot id: F7E7B9
names: Similarity
messages: Belongs to the requiem/DPF family.

9544:TOM1L1
gene id: 9544:TOM1L1
uniprot id: F7D0F3
names: Similarity
messages: Belongs to the TOM1 family.

9544:AK8
gene id: 9544:AK8
uniprot id: G7NFH2
names: Similarity
messages: Belongs to the adenylate kinase family.

9544:PLAGL2
gene id: 9544:PLAGL2
uniprot id: A0A8J8XKN9
uniprot id: I2CW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9544:SPDL1
gene id: 9544:SPDL1
uniprot id: H9EW97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9544:ADRB3
gene id: 9544:ADRB3
uniprot id: Q28524
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.

9544:DLD
gene id: 9544:DLD
uniprot id: A0A8J8XRG6
uniprot id: H9Z5Y2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9544:MEP1A
gene id: 9544:MEP1A
uniprot id: A0A8J8YQC1
uniprot id: F6TID4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SMPD1
gene id: 9544:SMPD1
uniprot id: F7C9N4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9544:LOC718452
gene id: 9544:LOC718452
uniprot id: A0A5F7ZH52
names: Subcellular Location Annotation
messages: Membrane

9544:CDX4
gene id: 9544:CDX4
uniprot id: A0A8J8YF80
uniprot id: F6YHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9544:SIX2
gene id: 9544:SIX2
uniprot id: A0A8J8YNT7
uniprot id: F7HAN3
uniprot id: G7N9Z8
names: Subcellular Location Annotation
messages: Nucleus

9544:GSTT2B
gene id: 9544:GSTT2B
uniprot id: A0A023JCH0
uniprot id: G8F1C9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:KCNMB3
gene id: 9544:KCNMB3
uniprot id: G7MJ91
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9544:PLD4
gene id: 9544:PLD4
uniprot id: F7CNC1
names: Similarity
messages: Belongs to the phospholipase D family.

9544:NAA60
gene id: 9544:NAA60
uniprot id: H9ET69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9544:COA5
gene id: 9544:COA5
uniprot id: I0FMJ9
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9544:EIF1AX
gene id: 9544:EIF1AX
uniprot id: H9EP53
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9544:PCK2
gene id: 9544:PCK2
uniprot id: F7E8L2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9544:FABP3
gene id: 9544:FABP3
uniprot id: A0A8J8YTA0
uniprot id: G7MI71
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:FAM160A2
gene id: 9544:FAM160A2
uniprot id: A0A8J8YSH1
uniprot id: F7BPS8
uniprot id: H9YYB8
names: Similarity
messages: Belongs to the FHIP family.

9544:NUBP1
gene id: 9544:NUBP1
uniprot id: G7NPM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9544:CDH13
gene id: 9544:CDH13
uniprot id: A0A5K1URB0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

9544:CAPNS1
gene id: 9544:CAPNS1
uniprot id: F6X9V6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

9544:POLD3
gene id: 9544:POLD3
uniprot id: A0A8J8XFJ8
uniprot id: F7BL41
names: Subcellular Location Annotation
messages: Nucleus

9544:HOXB5
gene id: 9544:HOXB5
uniprot id: A0A5F7ZKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:RABEP2
gene id: 9544:RABEP2
uniprot id: F7DWW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Early endosome
messages: Endosome
messages: centrosome
messages: cilium basal body

9544:SGK1
gene id: 9544:SGK1
uniprot id: A0A5K1VLQ6
uniprot id: F7GPM7
uniprot id: I0FU80
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:OLFM3
gene id: 9544:OLFM3
uniprot id: A0A8J8Y6U0
uniprot id: F7H3M5
uniprot id: F7HKM5
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9544:LOC735307
gene id: 9544:LOC735307
uniprot id: Q07367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9544:RNF182
gene id: 9544:RNF182
uniprot id: A0A8J8XTH4
uniprot id: F7HNS9
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9544:SLITRK3
gene id: 9544:SLITRK3
uniprot id: A0A8J8YQ26
uniprot id: F7GMP9
names: Similarity
messages: Belongs to the SLITRK family.

9544:ENTPD5
gene id: 9544:ENTPD5
uniprot id: F7ANV4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:HOXC9
gene id: 9544:HOXC9
uniprot id: H9H5R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9544:LOC712274
gene id: 9544:LOC712274
uniprot id: I2CY97
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9544:IZUMO3
gene id: 9544:IZUMO3
uniprot id: A0A5F7ZES2
uniprot id: A0A5F7ZV17
names: Similarity
messages: Belongs to the Izumo family.

9544:TMA16
gene id: 9544:TMA16
uniprot id: F7GIE4
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9544:SELL
gene id: 9544:SELL
uniprot id: Q95198
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: N-glycosylated.

9544:RPA3
gene id: 9544:RPA3
uniprot id: F6TGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9544:MGA
gene id: 9544:MGA
uniprot id: F6TX76
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:KRT23
gene id: 9544:KRT23
uniprot id: A0A8J8Y793
uniprot id: F7GFR0
names: Similarity
messages: Belongs to the intermediate filament family.

9544:CALR3
gene id: 9544:CALR3
uniprot id: A0A8J8XT33
uniprot id: G7NMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9544:ACP1
gene id: 9544:ACP1
uniprot id: A0A5F7ZVN7
uniprot id: G7NB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9544:RORB
gene id: 9544:RORB
uniprot id: A0A1D5QER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:TMEM263
gene id: 9544:TMEM263
uniprot id: A0A8J8YS10
uniprot id: F6WHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9544:UPK1B
gene id: 9544:UPK1B
uniprot id: A0A1D5RG23
uniprot id: A0A8J8XMS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9544:PLAG1
gene id: 9544:PLAG1
uniprot id: A0A8J8XCT4
uniprot id: F7EA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9544:GDI2
gene id: 9544:GDI2
uniprot id: H9ELY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9544:LOC706087
gene id: 9544:LOC706087
uniprot id: F7HDP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9544:PTPN3
gene id: 9544:PTPN3
uniprot id: A0A8J8YIZ4
uniprot id: F7D361
uniprot id: F7HG49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9544:NSRP1
gene id: 9544:NSRP1
uniprot id: H9EXD6
names: Similarity
messages: Belongs to the NSRP1 family.

9544:NR2C2
gene id: 9544:NR2C2
uniprot id: A0A1D5RHB0
uniprot id: A0A8J8XKY0
uniprot id: F7D8H6
uniprot id: G7N7T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:GPC5
gene id: 9544:GPC5
uniprot id: F6WEN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9544:B3GAT1
gene id: 9544:B3GAT1
uniprot id: A0A1D5QFY7
uniprot id: A0A5F8AIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:EXOC1
gene id: 9544:EXOC1
uniprot id: A0A8J8XPZ5
uniprot id: F7F553
uniprot id: H9FX21
uniprot id: H9YUY3
names: Similarity
messages: Belongs to the SEC3 family.

9544:U2AF2
gene id: 9544:U2AF2
uniprot id: F6RZR0
uniprot id: H9ELZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9544:ROMO1
gene id: 9544:ROMO1
uniprot id: H9EQP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9544:ATPAF2
gene id: 9544:ATPAF2
uniprot id: A0A8J8XAV3
uniprot id: H9YWY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9544:SLC13A2
gene id: 9544:SLC13A2
uniprot id: A0A1D5Q6Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9544:DCLRE1C
gene id: 9544:DCLRE1C
uniprot id: E5FGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9544:LOC706634
gene id: 9544:LOC706634
uniprot id: F7A219
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:DCTD
gene id: 9544:DCTD
uniprot id: A0A5F8AEQ9
uniprot id: H9FQN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

9544:TADA2A
gene id: 9544:TADA2A
uniprot id: A0A8J8XQ07
uniprot id: G7NI12
names: Subcellular Location Annotation
messages: Nucleus

9544:KCNAB2
gene id: 9544:KCNAB2
uniprot id: F7C3Q4
uniprot id: H9Z2J9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: axon
messages: cytoskeleton
messages: synaptosome

9544:INKA1
gene id: 9544:INKA1
uniprot id: F7HMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9544:ATP9B
gene id: 9544:ATP9B
uniprot id: G7NKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:EIF1
gene id: 9544:EIF1
uniprot id: A0A8J8Y6N6
uniprot id: G7NIJ1
names: Similarity
messages: Belongs to the SUI1 family.

9544:MARVELD2
gene id: 9544:MARVELD2
uniprot id: A0A1D5QAA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:INHA
gene id: 9544:INHA
uniprot id: A0A8J8YPZ7
uniprot id: Q5SEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9544:ANXA9
gene id: 9544:ANXA9
uniprot id: F7E6S3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:RHAG
gene id: 9544:RHAG
uniprot id: Q9GMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9544:VEGFB
gene id: 9544:VEGFB
uniprot id: F6RJK6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9544:STXBP1
gene id: 9544:STXBP1
uniprot id: A0A1D5Q217
uniprot id: F7FLD8
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:LGALS3
gene id: 9544:LGALS3
uniprot id: A0A8J8XX84
uniprot id: G7MXY8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:SDE2
gene id: 9544:SDE2
uniprot id: H9EXN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9544:DHRS7
gene id: 9544:DHRS7
uniprot id: A0A5F8AVE4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:ITGB6
gene id: 9544:ITGB6
uniprot id: A0A1D5QZT0
uniprot id: A0A8J8XVJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9544:RNF40
gene id: 9544:RNF40
uniprot id: A0A8J8YLD1
uniprot id: F7HL62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9544:UBA5
gene id: 9544:UBA5
uniprot id: H9EVI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9544:C14H11orf58
gene id: 9544:C14H11orf58
uniprot id: A0A8J8XTK0
uniprot id: F6W3H8
names: Similarity
messages: Belongs to the SMAP family.

9544:CDH22
gene id: 9544:CDH22
uniprot id: F7GIE7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:NRDE2
gene id: 9544:NRDE2
uniprot id: H9YZ13
names: Similarity
messages: Belongs to the NRDE2 family.

9544:NAB2
gene id: 9544:NAB2
uniprot id: F6UUT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9544:APOBEC3B
gene id: 9544:APOBEC3B
uniprot id: F6M3K5
names: Subcellular Location Annotation
messages: Cytoplasm

9544:PARL
gene id: 9544:PARL
uniprot id: H9EWC9
names: Subcellular Location Annotation
messages: Membrane

9544:MICAL1
gene id: 9544:MICAL1
uniprot id: F7EAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9544:UFC1
gene id: 9544:UFC1
uniprot id: H9ELX9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9544:UBE2B
gene id: 9544:UBE2B
uniprot id: A0A8J8Y4G8
uniprot id: H9YWP0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:DKK1
gene id: 9544:DKK1
uniprot id: A0A8J8YG19
uniprot id: F7G3K1
names: Similarity
messages: Belongs to the dickkopf family.

9544:E2F1
gene id: 9544:E2F1
uniprot id: F7DEJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:DVL3
gene id: 9544:DVL3
uniprot id: H9ENW4
names: Similarity
messages: Belongs to the DSH family.

9544:CHST9
gene id: 9544:CHST9
uniprot id: A0A8J8XKX8
uniprot id: G7NKI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:HIST1H2AC
gene id: 9544:HIST1H2AC
uniprot id: A0A8J8YN90
uniprot id: F7HAP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SAXO1
gene id: 9544:SAXO1
uniprot id: F7GZG2
names: Similarity
messages: Belongs to the FAM154 family.

9544:ORC3
gene id: 9544:ORC3
uniprot id: H9FS88
uniprot id: I0FI50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9544:SNCG
gene id: 9544:SNCG
uniprot id: A0A8J8XDQ0
uniprot id: G7N202
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9544:IL1RAP
gene id: 9544:IL1RAP
uniprot id: P59822
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane
messages: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
messages: Secreted
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
messages: The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).

9544:GLG1
gene id: 9544:GLG1
uniprot id: A0A1D5Q1M7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9544:LEP
gene id: 9544:LEP
uniprot id: Q28504
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Secreted

9544:NTS
gene id: 9544:NTS
uniprot id: A0A8J8XPI2
uniprot id: F7FDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9544:ST6GALNAC3
gene id: 9544:ST6GALNAC3
uniprot id: A0A5K1VDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:EVA1B
gene id: 9544:EVA1B
uniprot id: I0FT16
names: Similarity
messages: Belongs to the EVA1 family.

9544:VGLL4
gene id: 9544:VGLL4
uniprot id: A0A1D5QPS6
uniprot id: A0A8J8XJK8
uniprot id: G7MKQ2
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9544:SLC35B1
gene id: 9544:SLC35B1
uniprot id: A0A8J8YEB6
uniprot id: G7NHF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9544:LVRN
gene id: 9544:LVRN
uniprot id: A0A8J8XUD3
uniprot id: F7CIN8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9544:PWWP3B
gene id: 9544:PWWP3B
uniprot id: F7EH17
names: Similarity
messages: Belongs to the PWWP3A family.

9544:SPNS1
gene id: 9544:SPNS1
uniprot id: A0A8J8XJR0
uniprot id: F7EV02
uniprot id: G7NQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9544:LCN8
gene id: 9544:LCN8
uniprot id: D1YSI8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:RB1
gene id: 9544:RB1
uniprot id: I2CVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9544:CENPA
gene id: 9544:CENPA
uniprot id: A0A8J8Y733
uniprot id: F7AJX7
names: Similarity
messages: Belongs to the histone H3 family.

9544:MCL1
gene id: 9544:MCL1
uniprot id: F7HUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9544:YAE1
gene id: 9544:YAE1
uniprot id: G7MLG1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:RPS28
gene id: 9544:RPS28
uniprot id: F7AA98
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

9544:SLC25A45
gene id: 9544:SLC25A45
uniprot id: F7FBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:YWHAH
gene id: 9544:YWHAH
uniprot id: F6RIX6
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:CA5B
gene id: 9544:CA5B
uniprot id: A0A8J8Y6K8
uniprot id: G7NSA8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9544:SMAD2
gene id: 9544:SMAD2
uniprot id: A0A8J8Y228
uniprot id: F7CIW0
uniprot id: F7CP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:SPAST
gene id: 9544:SPAST
uniprot id: H9FYV4
uniprot id: H9FYV5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9544:SMNDC1
gene id: 9544:SMNDC1
uniprot id: F7CVM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

9544:LOC714964
gene id: 9544:LOC714964
uniprot id: B0Z9U9
uniprot id: V5NSD8
names: Similarity
messages: Belongs to the MHC class I family.

9544:PON1
gene id: 9544:PON1
uniprot id: A0A8J8YIF5
uniprot id: F7H7J8
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9544:ALB
gene id: 9544:ALB
uniprot id: F7HCH0
uniprot id: Q28522
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-265 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

9544:ZNF287
gene id: 9544:ZNF287
uniprot id: A0A8J8XAD3
uniprot id: G7NJ00
names: Subcellular Location Annotation
messages: Nucleus

9544:MTG2
gene id: 9544:MTG2
uniprot id: A0A5K1U680
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9544:VDAC2
gene id: 9544:VDAC2
uniprot id: H9FZD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9544:MCM2
gene id: 9544:MCM2
uniprot id: A0A5K1URQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:BSCL2
gene id: 9544:BSCL2
uniprot id: A0A5K1V2S6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:DRD2
gene id: 9544:DRD2
uniprot id: F7CYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9544:HOXD9
gene id: 9544:HOXD9
uniprot id: A0A1D5QBX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:PRXL2A
gene id: 9544:PRXL2A
uniprot id: A0A5F7ZH91
uniprot id: H9Z3J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9544:SOGA3
gene id: 9544:SOGA3
uniprot id: F7BRJ0
names: Similarity
messages: Belongs to the SOGA family.

9544:ZDHHC5
gene id: 9544:ZDHHC5
uniprot id: H9YVU5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:HMGB2
gene id: 9544:HMGB2
uniprot id: H9EQP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9544:PQLC1
gene id: 9544:PQLC1
uniprot id: F7GUY0
names: Subcellular Location Annotation
messages: Membrane

9544:ACSS2
gene id: 9544:ACSS2
uniprot id: F7EME7
uniprot id: I2CVW8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:TMEM11
gene id: 9544:TMEM11
uniprot id: A0A8J8XZM4
uniprot id: F6UDS1
uniprot id: F7HL31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9544:FAM168B
gene id: 9544:FAM168B
uniprot id: A0A8J8YQ58
uniprot id: G7NB68
names: Similarity
messages: Belongs to the FAM168 family.

9544:CHFR
gene id: 9544:CHFR
uniprot id: F7GD66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9544:UCK2
gene id: 9544:UCK2
uniprot id: F6ZWL3
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9544:C1GALT1
gene id: 9544:C1GALT1
uniprot id: A0A5F7ZS52
uniprot id: F7GRL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9544:CCDC126
gene id: 9544:CCDC126
uniprot id: A0A8J8YJW1
uniprot id: F6VKK5
names: Subcellular Location Annotation
messages: Secreted

9544:TBX4
gene id: 9544:TBX4
uniprot id: A0A5F8AJ78
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:TECR
gene id: 9544:TECR
uniprot id: H9Z0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ATP5PB
gene id: 9544:ATP5PB
uniprot id: H9FVK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9544:ACE2
gene id: 9544:ACE2
uniprot id: B6DUG6
uniprot id: F7AH40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9544:SLC25A40
gene id: 9544:SLC25A40
uniprot id: F7H3V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9544:LOC719903
gene id: 9544:LOC719903
uniprot id: F6YKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:POU3F4
gene id: 9544:POU3F4
uniprot id: A0A8J8XFV1
uniprot id: F7DRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9544:SLURP2
gene id: 9544:SLURP2
uniprot id: P0DP61
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.
messages: Interacts with CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB2 and CHRNB4. Interacts with CHRM1 and CHRM3 probably in an allosteric manner (By similarity).
messages: Secreted

9544:HS6ST1
gene id: 9544:HS6ST1
uniprot id: H9ZFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9544:GINS3
gene id: 9544:GINS3
uniprot id: I0FJM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9544:AKR1E2
gene id: 9544:AKR1E2
uniprot id: F7HGX6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:N4BP3
gene id: 9544:N4BP3
uniprot id: F6WBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9544:S100A2
gene id: 9544:S100A2
uniprot id: F7GDD5
names: Similarity
messages: Belongs to the S-100 family.

9544:GNRHR
gene id: 9544:GNRHR
uniprot id: F7GVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MT2A
gene id: 9544:MT2A
uniprot id: A0A8J8Y2M7
uniprot id: G7NPC6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:RPL15
gene id: 9544:RPL15
uniprot id: F7HBX0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9544:ZRANB2
gene id: 9544:ZRANB2
uniprot id: F7HS64
uniprot id: H9ENU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9544:FAM91A1
gene id: 9544:FAM91A1
uniprot id: H9Z076
names: Similarity
messages: Belongs to the FAM91 family.

9544:IARS
gene id: 9544:IARS
uniprot id: H9Z8F3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:FAM241A
gene id: 9544:FAM241A
uniprot id: A0A5F8AKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9544:ATXN3
gene id: 9544:ATXN3
uniprot id: H9FUL0
names: Subcellular Location Annotation
messages: Nucleus

9544:VPS18
gene id: 9544:VPS18
uniprot id: A0A8J8YEV3
uniprot id: F7G761
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9544:TMEM198
gene id: 9544:TMEM198
uniprot id: A0A8J8Y6B1
uniprot id: H9EU83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9544:PARK7
gene id: 9544:PARK7
uniprot id: H9FPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9544:TRIM15
gene id: 9544:TRIM15
uniprot id: Q5TM55
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9544:GTF2I
gene id: 9544:GTF2I
uniprot id: F7GXN0
uniprot id: H9EN54
uniprot id: I0FR62
uniprot id: I2CU05
names: Subcellular Location Annotation
messages: Nucleus

9544:TMC7
gene id: 9544:TMC7
uniprot id: A0A8J8YGH2
uniprot id: F6QV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9544:STAM2
gene id: 9544:STAM2
uniprot id: F7GA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9544:GPHN
gene id: 9544:GPHN
uniprot id: A0A8J8YN59
uniprot id: H9FNK4
uniprot id: H9Z463
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9544:PPP2R2A
gene id: 9544:PPP2R2A
uniprot id: H9FWK6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:PLN
gene id: 9544:PLN
uniprot id: F6ZMW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9544:GNB2
gene id: 9544:GNB2
uniprot id: H9Z7W5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:RNF167
gene id: 9544:RNF167
uniprot id: G7NI39
names: Subcellular Location Annotation
messages: Membrane

9544:SFXN1
gene id: 9544:SFXN1
uniprot id: A0A5F7ZTM7
uniprot id: F7DBC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9544:AMBP
gene id: 9544:AMBP
uniprot id: F6UQI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9544:C19H19orf24
gene id: 9544:C19H19orf24
uniprot id: F7DU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9544:ESR2
gene id: 9544:ESR2
uniprot id: A0A8J8Y110
uniprot id: I2CWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9544:RGS4
gene id: 9544:RGS4
uniprot id: A0A663DBJ0
uniprot id: F7CYN6
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9544:MFAP2
gene id: 9544:MFAP2
uniprot id: A0A5F8AIN0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:TRMT10C
gene id: 9544:TRMT10C
uniprot id: A0A8J8Y0E4
uniprot id: F7EUC5
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9544:FAM76B
gene id: 9544:FAM76B
uniprot id: A0A8J8XR52
uniprot id: F6WCW5
names: Similarity
messages: Belongs to the FAM76 family.

9544:GPBP1L1
gene id: 9544:GPBP1L1
uniprot id: A0A8J8XN46
uniprot id: F6VH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9544:TMEM9
gene id: 9544:TMEM9
uniprot id: A0A8J8YIL4
uniprot id: F6ZEB5
uniprot id: F6ZER3
names: Similarity
messages: Belongs to the TMEM9 family.

9544:MIF
gene id: 9544:MIF
uniprot id: I2CYD8
uniprot id: Q6DN04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).
messages: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
messages: Secreted

9544:KCNQ2
gene id: 9544:KCNQ2
uniprot id: F7ASA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TMED3
gene id: 9544:TMED3
uniprot id: F7FTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:OR2B3
gene id: 9544:OR2B3
uniprot id: A0A8J8YN75
uniprot id: F7GT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:GABRA6
gene id: 9544:GABRA6
uniprot id: G7MVU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:KCNH2
gene id: 9544:KCNH2
uniprot id: F6WED3
names: Subcellular Location Annotation
messages: Membrane

9544:CD40LG
gene id: 9544:CD40LG
uniprot id: P63304
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9544:RIDA
gene id: 9544:RIDA
uniprot id: H9FNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9544:LOC693939
gene id: 9544:LOC693939
uniprot id: A0A5F7ZSU9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ATP1A3
gene id: 9544:ATP1A3
uniprot id: F7HPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9544:CFL1
gene id: 9544:CFL1
uniprot id: I0FG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9544:GNAI2
gene id: 9544:GNAI2
uniprot id: A0A8J8XXB1
uniprot id: I0FJU1
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:GDPD1
gene id: 9544:GDPD1
uniprot id: H9FT85
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9544:SRP54
gene id: 9544:SRP54
uniprot id: A0A1D5Q506
uniprot id: A0A8J8YIP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

9544:ENO3
gene id: 9544:ENO3
uniprot id: A0A8J8XQF7
uniprot id: F7E3W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:CLTA
gene id: 9544:CLTA
uniprot id: A0A1D5RAM5
uniprot id: H9EPP9
uniprot id: H9FPR3
uniprot id: H9FPR4
uniprot id: H9YUB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9544:SLC25A42
gene id: 9544:SLC25A42
uniprot id: A0A8J8XEW5
uniprot id: F7CMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:LOC696748
gene id: 9544:LOC696748
uniprot id: A0A8J8YR21
uniprot id: F7D4K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9544:ACP7
gene id: 9544:ACP7
uniprot id: A0A8J8YHF5
uniprot id: G7NNK0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9544:TMEM229B
gene id: 9544:TMEM229B
uniprot id: A0A8J8XSK5
uniprot id: F7FXH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9544:SEC31A
gene id: 9544:SEC31A
uniprot id: F6WSK0
uniprot id: H9FRF6
uniprot id: H9FRF7
uniprot id: H9FRF8
uniprot id: H9Z6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:GOLT1A
gene id: 9544:GOLT1A
uniprot id: A0A8J8YIJ8
uniprot id: F7H558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9544:TMPO
gene id: 9544:TMPO
uniprot id: A0A1D5Q2B0
uniprot id: F7HAU0
uniprot id: F7HAV4
uniprot id: H9FZ48
names: Similarity
messages: Belongs to the LEM family.

9544:OST4
gene id: 9544:OST4
uniprot id: I2CYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:MTF2
gene id: 9544:MTF2
uniprot id: F7GY59
uniprot id: H9Z6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:HMGCL
gene id: 9544:HMGCL
uniprot id: A0A5K1UZL0
uniprot id: H9Z8B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9544:TENT5B
gene id: 9544:TENT5B
uniprot id: F7H3A9
names: Similarity
messages: Belongs to the TENT family.

9544:LOC100423855
gene id: 9544:LOC100423855
uniprot id: A0A1D5Q1X7
names: Similarity
messages: Belongs to the MS4A family.

9544:RUNX1
gene id: 9544:RUNX1
uniprot id: F6PP34
uniprot id: H9YWG8
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9544:GMPPB
gene id: 9544:GMPPB
uniprot id: F7GRF0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9544:SF3B1
gene id: 9544:SF3B1
uniprot id: A0A8J8Y5B4
uniprot id: G7N8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9544:YWHAE
gene id: 9544:YWHAE
uniprot id: A0A1D5Q9M4
uniprot id: A0A1D5QIF8
uniprot id: I0FUX3
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:PSMC2
gene id: 9544:PSMC2
uniprot id: H9FXE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9544:TSPAN4
gene id: 9544:TSPAN4
uniprot id: H9FZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:PRRT1
gene id: 9544:PRRT1
uniprot id: F6UY02
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:SH3BGRL2
gene id: 9544:SH3BGRL2
uniprot id: H9G0H1
names: Similarity
messages: Belongs to the SH3BGR family.

9544:C6H5orf30
gene id: 9544:C6H5orf30
uniprot id: A0A8J8XGM7
uniprot id: F6Z3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9544:MDFIC
gene id: 9544:MDFIC
uniprot id: A0A1D5R9M0
names: Similarity
messages: Belongs to the MDFI family.

9544:STX16
gene id: 9544:STX16
uniprot id: F7GS43
uniprot id: H9ERQ2
uniprot id: H9EU73
uniprot id: H9YUI6
uniprot id: H9YUI7
names: Similarity
messages: Belongs to the peptidase M17 family.
messages: Belongs to the syntaxin family.

9544:IFRD2
gene id: 9544:IFRD2
uniprot id: F7GI34
names: Similarity
messages: Belongs to the IFRD family.

9544:PISD
gene id: 9544:PISD
uniprot id: F6QD04
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9544:TMEM265
gene id: 9544:TMEM265
uniprot id: A0A5F8A5G6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:IRF6
gene id: 9544:IRF6
uniprot id: A0A8J8YHB4
uniprot id: F7HP73
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:MMP12
gene id: 9544:MMP12
uniprot id: F6YVM2
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:MOB4
gene id: 9544:MOB4
uniprot id: F6W5F5
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:NMBR
gene id: 9544:NMBR
uniprot id: A0A5F8ANT7
uniprot id: F7F9U3
uniprot id: Q6H2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TIMP3
gene id: 9544:TIMP3
uniprot id: G1K371
uniprot id: Q5PXZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).
messages: Interacts with EFEMP1.
messages: extracellular matrix

9544:PREPL
gene id: 9544:PREPL
uniprot id: A0A8J8Y7N3
uniprot id: G7N9Z5
names: Similarity
messages: Belongs to the peptidase S9A family.

9544:PMM1
gene id: 9544:PMM1
uniprot id: H9FVY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9544:NME2
gene id: 9544:NME2
uniprot id: A0A5F8AMZ3
names: Similarity
messages: Belongs to the NDK family.

9544:LIMS2
gene id: 9544:LIMS2
uniprot id: I2CUQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9544:KDR
gene id: 9544:KDR
uniprot id: F7E313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:GBE1
gene id: 9544:GBE1
uniprot id: A0A8J8Y393
uniprot id: F7C130
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9544:CHST11
gene id: 9544:CHST11
uniprot id: A0A8J8YLH7
uniprot id: H9Z9G6
uniprot id: H9Z9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:EIF4A3
gene id: 9544:EIF4A3
uniprot id: H9Z1T8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:RPL36AL
gene id: 9544:RPL36AL
uniprot id: A0A8J8Y079
uniprot id: F6VSQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9544:RARRES2
gene id: 9544:RARRES2
uniprot id: H9H322
names: Subcellular Location Annotation
messages: Secreted

9544:HRH4
gene id: 9544:HRH4
uniprot id: F6WWD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:OPRK1
gene id: 9544:OPRK1
uniprot id: H9FL65
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

9544:ADPRM
gene id: 9544:ADPRM
uniprot id: A0A5F7ZCS6
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9544:GLA
gene id: 9544:GLA
uniprot id: A0A1D5QJU3
uniprot id: A0A8J8YLE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9544:GPR119
gene id: 9544:GPR119
uniprot id: A0A8J8XYN1
uniprot id: F7HMG7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GIMAP8
gene id: 9544:GIMAP8
uniprot id: G7MNA2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9544:EFNA1
gene id: 9544:EFNA1
uniprot id: A0A5F8AJF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CLRN1
gene id: 9544:CLRN1
uniprot id: G7MJH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9544:TOR1A
gene id: 9544:TOR1A
uniprot id: A0A5F8A5L1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: Membrane
messages: growth cone

9544:FAM219B
gene id: 9544:FAM219B
uniprot id: H9EV71
names: Similarity
messages: Belongs to the FAM219 family.

9544:SMPX
gene id: 9544:SMPX
uniprot id: A0A8J8XT44
uniprot id: F7C405
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9544:COX14
gene id: 9544:COX14
uniprot id: A0A5K1TXQ5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9544:PSAT1
gene id: 9544:PSAT1
uniprot id: F7H2J6
uniprot id: F7H2J8
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9544:CNOT7
gene id: 9544:CNOT7
uniprot id: F7GMT4
uniprot id: H9ENJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9544:APEX2
gene id: 9544:APEX2
uniprot id: F6VBU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9544:LOC100429047
gene id: 9544:LOC100429047
uniprot id: A0A5F8AMY6
names: Similarity
messages: Belongs to the PRR20 family.

9544:SCAI
gene id: 9544:SCAI
uniprot id: A0A5F7ZS23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9544:HSPA9
gene id: 9544:HSPA9
uniprot id: H9FTU4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:SMIM19
gene id: 9544:SMIM19
uniprot id: A0A8J8XRT9
uniprot id: G7MZ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9544:MSANTD3
gene id: 9544:MSANTD3
uniprot id: F6ZHT8
names: Similarity
messages: Belongs to the MSANTD3 family.

9544:ZSCAN16
gene id: 9544:ZSCAN16
uniprot id: A0A8J8Y505
uniprot id: F7EHB8
names: Subcellular Location Annotation
messages: Nucleus

9544:ADRA1B
gene id: 9544:ADRA1B
uniprot id: A0A5F8ASX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9544:INPP5K
gene id: 9544:INPP5K
uniprot id: A0A8J8XR49
uniprot id: H9YXQ4
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9544:IRF7
gene id: 9544:IRF7
uniprot id: B6CJX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:CYSTM1
gene id: 9544:CYSTM1
uniprot id: A0A8J8YES8
uniprot id: F6YFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

9544:TSPAN3
gene id: 9544:TSPAN3
uniprot id: F6QHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:NOP56
gene id: 9544:NOP56
uniprot id: F6R553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9544:RNASE9
gene id: 9544:RNASE9
uniprot id: D1YSI5
uniprot id: W0UVD8
names: Function
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.

9544:NDC1
gene id: 9544:NDC1
uniprot id: G7MH71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

9544:CDH2
gene id: 9544:CDH2
uniprot id: F6WI86
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Cell surface
messages: Membrane
messages: sarcolemma

9544:SIN3A
gene id: 9544:SIN3A
uniprot id: F7H3V1
names: Subcellular Location Annotation
messages: Nucleus

9544:F11R
gene id: 9544:F11R
uniprot id: F6WSS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:SMG8
gene id: 9544:SMG8
uniprot id: F7HS41
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9544:RING1
gene id: 9544:RING1
uniprot id: F7H862
uniprot id: Q8WMN5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of chromatin-associated Polycomb (PcG) complexes. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PHC2, PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with BMI1 (By similarity). Interacts with MN1 (By similarity).
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

9544:TMEM94
gene id: 9544:TMEM94
uniprot id: A0A1D5RGG1
names: Subcellular Location Annotation
messages: Membrane

9544:SGMS2
gene id: 9544:SGMS2
uniprot id: A0A8J8YDE5
uniprot id: F7DR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9544:BPGM
gene id: 9544:BPGM
uniprot id: A0A8J8YL24
uniprot id: H9ER39
uniprot id: I0FUG9
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9544:OR5AN1
gene id: 9544:OR5AN1
uniprot id: A0A8J8Y1U4
uniprot id: F7C1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NCBP3
gene id: 9544:NCBP3
uniprot id: A0A5K1UWR4
uniprot id: A0A8J8YE83
uniprot id: G7NHW2
names: Similarity
messages: Belongs to the NCBP3 family.

9544:ACTL9
gene id: 9544:ACTL9
uniprot id: G7NNB1
names: Similarity
messages: Belongs to the actin family.

9544:NXN
gene id: 9544:NXN
uniprot id: F6VRC1
names: Similarity
messages: Belongs to the nucleoredoxin family.

9544:FGFBP1
gene id: 9544:FGFBP1
uniprot id: F7HE10
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9544:CYP2C93
gene id: 9544:CYP2C93
uniprot id: F1ADG8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:PRKAB2
gene id: 9544:PRKAB2
uniprot id: A0A1D5QWE9
uniprot id: A0A8J8Y7V9
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9544:ZWILCH
gene id: 9544:ZWILCH
uniprot id: A0A5K1ULI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9544:PPM1A
gene id: 9544:PPM1A
uniprot id: A0A1D5R334
uniprot id: A0A5F8AQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9544:CHN1
gene id: 9544:CHN1
uniprot id: F7ET58
names: Function
messages: GTPase-activating protein for p21-rac.

9544:SUCLG1
gene id: 9544:SUCLG1
uniprot id: A0A8J8YNS2
uniprot id: G7NAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9544:LRP4
gene id: 9544:LRP4
uniprot id: H9FUD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ARPC2
gene id: 9544:ARPC2
uniprot id: A0A1D5RJ31
uniprot id: A0A8J8YQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9544:CASKIN2
gene id: 9544:CASKIN2
uniprot id: A0A5F8A9P6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:RNASEH2A
gene id: 9544:RNASEH2A
uniprot id: F6U5A6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9544:MRPL36
gene id: 9544:MRPL36
uniprot id: H9H300
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9544:IFNE
gene id: 9544:IFNE
uniprot id: A0A7R8C3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:TOP1
gene id: 9544:TOP1
uniprot id: H9FZ51
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9544:CPQ
gene id: 9544:CPQ
uniprot id: H9FNP5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome
messages: Secreted

9544:EPHA6
gene id: 9544:EPHA6
uniprot id: F7EGZ3
names: Subcellular Location Annotation
messages: Membrane

9544:SCFD1
gene id: 9544:SCFD1
uniprot id: I0FQ93
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:PIK3CD
gene id: 9544:PIK3CD
uniprot id: H9ZA48
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:SUMO1
gene id: 9544:SUMO1
uniprot id: H9EMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9544:STN1
gene id: 9544:STN1
uniprot id: F6PY41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9544:TMPRSS2
gene id: 9544:TMPRSS2
uniprot id: F6SVR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CNFN
gene id: 9544:CNFN
uniprot id: A0A8J8YJ77
uniprot id: G7NLL8
names: Similarity
messages: Belongs to the cornifelin family.

9544:VPS52
gene id: 9544:VPS52
uniprot id: A0A5F8A6D4
uniprot id: A0A8J8Y601
names: Similarity
messages: Belongs to the VPS52 family.

9544:ARHGEF6
gene id: 9544:ARHGEF6
uniprot id: A0A5F7ZZM7
uniprot id: A0A5F8ARJ3
uniprot id: A0A8J8XW37
uniprot id: G7NRP9
names: Subcellular Location Annotation
messages: lamellipodium

9544:SERP2
gene id: 9544:SERP2
uniprot id: A0A1D5RKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9544:PTH2R
gene id: 9544:PTH2R
uniprot id: F7GM38
names: Subcellular Location Annotation
messages: Membrane

9544:TOP3B
gene id: 9544:TOP3B
uniprot id: H9YZX1
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9544:SLC9A5
gene id: 9544:SLC9A5
uniprot id: A0A5F8AIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9544:STK32B
gene id: 9544:STK32B
uniprot id: A0A8J8XNZ4
uniprot id: G7MSJ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:RGS1
gene id: 9544:RGS1
uniprot id: A0A5K1U7A0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:BORCS5
gene id: 9544:BORCS5
uniprot id: A0A1D5QQA7
uniprot id: A0A8J8YFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9544:NAP1L5
gene id: 9544:NAP1L5
uniprot id: H9FSW9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:CHM
gene id: 9544:CHM
uniprot id: A0A8J8XWL3
uniprot id: G7NSD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9544:LOC698056
gene id: 9544:LOC698056
uniprot id: A0A8J8Y577
uniprot id: F7B9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9544:RRAGA
gene id: 9544:RRAGA
uniprot id: A0A8J8XJQ4
uniprot id: G7NFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9544:NR2E1
gene id: 9544:NR2E1
uniprot id: A0A8J8XHU5
uniprot id: H9FZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:SCAMP3
gene id: 9544:SCAMP3
uniprot id: F6TUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:GPR20
gene id: 9544:GPR20
uniprot id: F6PT20
uniprot id: G8F1I2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:LAMP1
gene id: 9544:LAMP1
uniprot id: I0FRN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9544:DGAT2
gene id: 9544:DGAT2
uniprot id: F7HJJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HIRA
gene id: 9544:HIRA
uniprot id: A0A5F7ZHE5
uniprot id: H9ZD31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9544:FLOT1
gene id: 9544:FLOT1
uniprot id: A0A8J8Y099
uniprot id: G7MRG3
uniprot id: Q5TM70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Melanosome
messages: Membrane
messages: Membrane raft
messages: caveola

9544:LGI4
gene id: 9544:LGI4
uniprot id: A0A8J8XHE8
uniprot id: F7H5I3
uniprot id: G7NM39
names: Subcellular Location Annotation
messages: Secreted

9544:SERPIND1
gene id: 9544:SERPIND1
uniprot id: A0A8J8XJH4
uniprot id: F6XIG8
names: Similarity
messages: Belongs to the serpin family.

9544:ANAPC4
gene id: 9544:ANAPC4
uniprot id: H9ETG5
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

9544:MAP1LC3A
gene id: 9544:MAP1LC3A
uniprot id: F6UA91
names: Similarity
messages: Belongs to the ATG8 family.

9544:LOC708874
gene id: 9544:LOC708874
uniprot id: A0A5F7ZAH7
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:IFNA21
gene id: 9544:IFNA21
uniprot id: A0A7R8GUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:RPRM
gene id: 9544:RPRM
uniprot id: A0A8J8YE35
uniprot id: F6YH13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9544:SLC30A3
gene id: 9544:SLC30A3
uniprot id: H9FN88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:SLC40A1
gene id: 9544:SLC40A1
uniprot id: A0A5F8AQS1
uniprot id: A0A8J8XGY3
uniprot id: G7N8H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9544:FAM13C
gene id: 9544:FAM13C
uniprot id: F6S9M8
names: Similarity
messages: Belongs to the FAM13 family.

9544:BEX2
gene id: 9544:BEX2
uniprot id: A0A5F8AUH3
uniprot id: F6XD12
names: Similarity
messages: Belongs to the BEX family.

9544:DKK3
gene id: 9544:DKK3
uniprot id: F6WNA0
names: Similarity
messages: Belongs to the dickkopf family.

9544:DPYSL4
gene id: 9544:DPYSL4
uniprot id: H9H4A5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9544:ILKAP
gene id: 9544:ILKAP
uniprot id: H9YY70
names: Similarity
messages: Belongs to the PP2C family.

9544:LPIN1
gene id: 9544:LPIN1
uniprot id: A0A1D5QEP2
names: Similarity
messages: Belongs to the lipin family.

9544:BECN1
gene id: 9544:BECN1
uniprot id: F6PQC7
uniprot id: H9YW59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9544:ARMCX2
gene id: 9544:ARMCX2
uniprot id: A0A8J8YKL6
uniprot id: F6V1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9544:ATP1B4
gene id: 9544:ATP1B4
uniprot id: G7NRB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:UQCRC2
gene id: 9544:UQCRC2
uniprot id: F7HJV7
names: Similarity
messages: Belongs to the peptidase M16 family.

9544:DCP1A
gene id: 9544:DCP1A
uniprot id: A0A1D5Q7U9
uniprot id: A0A8J8YT15
names: Similarity
messages: Belongs to the DCP1 family.

9544:INO80D
gene id: 9544:INO80D
uniprot id: A0A8J8XXC6
uniprot id: F6QNA4
names: Subcellular Location Annotation
messages: Nucleus

9544:NLRP3
gene id: 9544:NLRP3
uniprot id: B0FPE9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc (By similarity). Activation upon, at least, K(+) efflux is mediated by the interaction wit NEK7 (By similarity). Activation in presence of cytosolic dsRNA is mediated by DHX33 (By similarity). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).
messages: Belongs to the NLRP family.
messages: Endoplasmic reticulum
messages: Highly expressed in oocyte, testis, spleen, thymus and kidney.
messages: Inflammasome
messages: Intramolecular interactions between NACHT and leucine-rich repeat (LRR) domains may be important for autoinhibition in the absence of activating signal.
messages: Nucleus
messages: Secreted
messages: Sensor component of NLRP3 inflammasomes. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. The core of NLRP3 inflammasomes consists of a signal sensor component (NLRP3), an adapter (ASC/PYCARD), which recruits an effector pro-inflammatory caspase (CASP1 and, possibly, CASP4 and CASP5). Within the complex, NLRP3 and PYCARD interact via their respective DAPIN/pyrin domains. This interaction initiates speck formation (nucleation) which greatly enhances further addition of soluble PYCARD molecules to the speck in a prion-like polymerization process. NLRP3 localizes at the end of each PYCARD filament. Clustered PYCARD nucleates the formation of CASP1 filaments through the interaction of their respective CARD domains, acting as a platform for CASP1 polymerization. CASP1 filament formation increases local enzyme concentration, resulting in trans-autocleavage and activation. Active CASP1 then processes IL1B and IL18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response. Reconstituted ternary inflammasomes show star-shaped structures, in which multiple filaments, containing CASP1, protrude radially from a single central hub, containing the sensor protein and PYCARD. In this complex, the sensor protein is sub-stoichiometric to PYCARD, and PYCARD is further substoichiometric to CASP1, suggesting amplifications of signal transduction from the sensor, via the adapter, to the effector. Interacts with MEFV; this interaction targets NLRP3 to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation. Interacts with GBP5 (via DAPIN domain); this interaction promotes inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autopho…
messages: The LRR domain mediates the interaction with IRF4 and PML.
messages: The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation.
messages: The pyrin domain (also called DAPIN domain or PYD) is involved in PYCARD-binding.
messages: Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Ubiquitination does not lead to degradation, but inhibits inflammasome activation (By similarity). Deubiquitination is catalyzed by BRCC3 and associated with NLRP3 activation and inflammasome assembly. This process can be induced by the activation of Toll-like receptors (by LPS), through a non-transcriptional pathway dependent on the mitochondrial production of reactive oxygen species, and by ATP (By similarity).
messages: Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33.
messages: cytosol

9544:LRP8
gene id: 9544:LRP8
uniprot id: F6SDB7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:IST1
gene id: 9544:IST1
uniprot id: A0A8J8XAH8
uniprot id: F6YAS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9544:TICAM1
gene id: 9544:TICAM1
uniprot id: B3Y697
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9544:PTCD3
gene id: 9544:PTCD3
uniprot id: F7AG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9544:DSC1
gene id: 9544:DSC1
uniprot id: A0A8J8XY34
uniprot id: F7HEJ3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9544:DZIP1
gene id: 9544:DZIP1
uniprot id: F6VD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9544:GLYAT
gene id: 9544:GLYAT
uniprot id: A0A8J8Y488
uniprot id: F7HA37
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9544:MCTP2
gene id: 9544:MCTP2
uniprot id: A0A8J8XRA0
uniprot id: G7MW13
names: Subcellular Location Annotation
messages: Membrane

9544:CLDN24
gene id: 9544:CLDN24
uniprot id: F7HH30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:TMEM50B
gene id: 9544:TMEM50B
uniprot id: H9FZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9544:NSFL1C
gene id: 9544:NSFL1C
uniprot id: F6XMH7
uniprot id: I0FG44
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9544:GAPVD1
gene id: 9544:GAPVD1
uniprot id: A0A5F8AJW6
uniprot id: F6TBD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9544:COPS2
gene id: 9544:COPS2
uniprot id: H9G1W2
uniprot id: H9G1W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9544:SPERT
gene id: 9544:SPERT
uniprot id: A0A8J8YC51
uniprot id: F7A315
uniprot id: F7H245
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

9544:LAPTM5
gene id: 9544:LAPTM5
uniprot id: F7DW52
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9544:LOC708065
gene id: 9544:LOC708065
uniprot id: I2CWI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9544:CYP2F1
gene id: 9544:CYP2F1
uniprot id: Q58HA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9544:RRN3
gene id: 9544:RRN3
uniprot id: A0A8J8XWN2
uniprot id: H9FW48
names: Similarity
messages: Belongs to the RRN3 family.

9544:TRAPPC13
gene id: 9544:TRAPPC13
uniprot id: F6WE11
uniprot id: H9G007
uniprot id: H9Z077
uniprot id: H9Z078
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9544:GALK2
gene id: 9544:GALK2
uniprot id: A0A1D5R7N5
uniprot id: A0A1D5RDV3
uniprot id: F7A7E8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9544:FASN
gene id: 9544:FASN
uniprot id: A0A5K1UCR4
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

9544:RAB9A
gene id: 9544:RAB9A
uniprot id: A0A8J8XA93
uniprot id: F6Z6I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9544:PDSS2
gene id: 9544:PDSS2
uniprot id: A0A8J8Y853
uniprot id: G7MQ10
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9544:SFN
gene id: 9544:SFN
uniprot id: A0A8J8XGW3
uniprot id: G7MHX1
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:LOC697790
gene id: 9544:LOC697790
uniprot id: I2CT89
names: Similarity
messages: Belongs to the ATG8 family.

9544:TMEM135
gene id: 9544:TMEM135
uniprot id: A0A5F8AEN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9544:CLDN22
gene id: 9544:CLDN22
uniprot id: A0A8J8XTZ7
uniprot id: F6S639
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:FOXJ1
gene id: 9544:FOXJ1
uniprot id: A0A8J8YA37
uniprot id: F7EXX8
names: Subcellular Location Annotation
messages: Nucleus

9544:TMEM147
gene id: 9544:TMEM147
uniprot id: A0A8J8XAS1
uniprot id: G7NM55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:HSF4
gene id: 9544:HSF4
uniprot id: I2CTP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:AMOT
gene id: 9544:AMOT
uniprot id: F6WTL5
names: Similarity
messages: Belongs to the angiomotin family.

9544:KCNT1
gene id: 9544:KCNT1
uniprot id: A0A1D5QUN2
uniprot id: F7FKC1
uniprot id: F7FKC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:RIPOR1
gene id: 9544:RIPOR1
uniprot id: F7H5B3
names: Similarity
messages: Belongs to the RIPOR family.

9544:RPL3L
gene id: 9544:RPL3L
uniprot id: F7HSX3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9544:TAF10
gene id: 9544:TAF10
uniprot id: F7C2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9544:TAS2R16
gene id: 9544:TAS2R16
uniprot id: A0A8J8XI06
uniprot id: Q645S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:LOC706606
gene id: 9544:LOC706606
uniprot id: F7HIX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9544:SLC6A9
gene id: 9544:SLC6A9
uniprot id: A0A5K1VBL3
uniprot id: F6UD64
uniprot id: H9FYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9544:TNF
gene id: 9544:TNF
uniprot id: A0A8J8YGV5
uniprot id: G7MRI3
uniprot id: P48094
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9544:EID1
gene id: 9544:EID1
uniprot id: H9FSA0
names: Subcellular Location Annotation
messages: Nucleus

9544:PDE3B
gene id: 9544:PDE3B
uniprot id: F6RK06
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:RPS14
gene id: 9544:RPS14
uniprot id: F7HI21
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9544:STOM
gene id: 9544:STOM
uniprot id: H9Z680
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9544:KRT40
gene id: 9544:KRT40
uniprot id: F6RQD9
names: Similarity
messages: Belongs to the intermediate filament family.

9544:PPP2CB
gene id: 9544:PPP2CB
uniprot id: F7HSM1
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:TNFSF8
gene id: 9544:TNFSF8
uniprot id: A0A1D5RK03
uniprot id: A0A8J8Y7E9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:PLK1
gene id: 9544:PLK1
uniprot id: A0A8J8XQA8
uniprot id: F7HSC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9544:SLC1A2
gene id: 9544:SLC1A2
uniprot id: A0A5F7ZDA8
uniprot id: A0A5F8A024
uniprot id: H9EM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9544:TMEM255A
gene id: 9544:TMEM255A
uniprot id: A0A8J8YE97
uniprot id: F6TJH0
uniprot id: F7FX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9544:AP2A2
gene id: 9544:AP2A2
uniprot id: I2CUB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9544:SIRT2
gene id: 9544:SIRT2
uniprot id: F7H1P7
uniprot id: H9YXU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9544:LYPD6
gene id: 9544:LYPD6
uniprot id: A0A8J8XG33
uniprot id: F7FWP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:ICAM1
gene id: 9544:ICAM1
uniprot id: Q5NKV6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
messages: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
messages: Membrane
messages: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

9544:UBE3D
gene id: 9544:UBE3D
uniprot id: A0A8J8XDP2
uniprot id: G7MPT3
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9544:RAD23A
gene id: 9544:RAD23A
uniprot id: A0A8J8XNZ1
uniprot id: G7NLC4
uniprot id: H9FXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9544:ADCYAP1R1
gene id: 9544:ADCYAP1R1
uniprot id: A0A1D5QCN0
uniprot id: A0A1D5QU32
names: Subcellular Location Annotation
messages: Membrane

9544:PPM1F
gene id: 9544:PPM1F
uniprot id: F7GFC1
uniprot id: G8F1V6
names: Similarity
messages: Belongs to the PP2C family.

9544:EYA2
gene id: 9544:EYA2
uniprot id: F7FR55
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9544:ELSPBP1
gene id: 9544:ELSPBP1
uniprot id: D1YSI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ALKBH2
gene id: 9544:ALKBH2
uniprot id: A0A5F8A7F8
uniprot id: A0A8J8XPX2
names: Similarity
messages: Belongs to the alkB family.

9544:PCYT1B
gene id: 9544:PCYT1B
uniprot id: A0A1D5RCC8
uniprot id: A0A8J8YE25
uniprot id: F6TCK2
uniprot id: H9EQB3
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9544:MED13
gene id: 9544:MED13
uniprot id: F7HAN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:KEG06 p04
gene id: 9544:KEG06_p04
uniprot id: Q6IYG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9544:XPNPEP2
gene id: 9544:XPNPEP2
uniprot id: A0A1D5RFF9
names: Similarity
messages: Belongs to the peptidase M24B family.

9544:SHMT2
gene id: 9544:SHMT2
uniprot id: A0A5F7ZEZ7
uniprot id: A0A5F7ZWZ7
uniprot id: A0A8J8Y9U0
uniprot id: G7N7F2
uniprot id: H9ES01
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9544:PYGM
gene id: 9544:PYGM
uniprot id: A0A8J8XUS0
uniprot id: F6Z728
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9544:HOXC6
gene id: 9544:HOXC6
uniprot id: A0A8J8Y0V9
uniprot id: F7HTX2
names: Subcellular Location Annotation
messages: Nucleus

9544:SPR
gene id: 9544:SPR
uniprot id: I2CXI8
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9544:HTR1D
gene id: 9544:HTR1D
uniprot id: A0A8J8YQ68
uniprot id: F7FW05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9544:MAT1A
gene id: 9544:MAT1A
uniprot id: F7ACZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9544:CCDC130
gene id: 9544:CCDC130
uniprot id: I0FVD3
names: Similarity
messages: Belongs to the CWC16 family.

9544:HBG2
gene id: 9544:HBG2
uniprot id: A0A8J8Y6X2
uniprot id: Q03903
names: Similarity
messages: Belongs to the globin family.

9544:UBA7
gene id: 9544:UBA7
uniprot id: F7HMU1
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9544:RABGGTB
gene id: 9544:RABGGTB
uniprot id: F7H489
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9544:TMTC2
gene id: 9544:TMTC2
uniprot id: H9FQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9544:MRGPRX1
gene id: 9544:MRGPRX1
uniprot id: Q1L4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:DCAF10
gene id: 9544:DCAF10
uniprot id: A0A1D5RAU4
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9544:MBTPS1
gene id: 9544:MBTPS1
uniprot id: G7NPE6
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:TOLLIP
gene id: 9544:TOLLIP
uniprot id: A0A1D5RG89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9544:AP3S1
gene id: 9544:AP3S1
uniprot id: A0A5F8A106
uniprot id: F6QF98
uniprot id: F7CIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9544:EEF1B2
gene id: 9544:EEF1B2
uniprot id: I0FGN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9544:SSBP3
gene id: 9544:SSBP3
uniprot id: A0A5F7ZAU9
uniprot id: F7HMU7
uniprot id: H9Z778
names: Subcellular Location Annotation
messages: Nucleus

9544:PGA4
gene id: 9544:PGA4
uniprot id: P11489
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9544:MARVELD1
gene id: 9544:MARVELD1
uniprot id: H9H444
names: Subcellular Location Annotation
messages: Membrane

9544:RAB3C
gene id: 9544:RAB3C
uniprot id: A0A5F7ZAL7
uniprot id: A0A8J8Y6H1
uniprot id: F7CYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9544:CAPZA2
gene id: 9544:CAPZA2
uniprot id: F7H1J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9544:TSPAN17
gene id: 9544:TSPAN17
uniprot id: I0FQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:RDH14
gene id: 9544:RDH14
uniprot id: A0A5F7ZSV8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:KRTAP3-3
gene id: 9544:KRTAP3-3
uniprot id: G7NIA6
names: Subunit
messages: Interacts with hair keratins.

9544:PNOC
gene id: 9544:PNOC
uniprot id: A0A8J8YDU4
uniprot id: H9FVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9544:PRR15L
gene id: 9544:PRR15L
uniprot id: A0A8J8Y833
uniprot id: F7EHE4
names: Similarity
messages: Belongs to the PRR15 family.

9544:KIF23
gene id: 9544:KIF23
uniprot id: A0A1D5QTA8
uniprot id: A0A1D5R7P0
uniprot id: F6TQ65
uniprot id: F6TQ74
uniprot id: H9ZFK8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:CCL27
gene id: 9544:CCL27
uniprot id: Q8HYP2
names: Subcellular Location Annotation
messages: Secreted

9544:CDK5R2
gene id: 9544:CDK5R2
uniprot id: F7CY39
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9544:WNT11
gene id: 9544:WNT11
uniprot id: F7EV26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:C4H6orf120
gene id: 9544:C4H6orf120
uniprot id: H9FMJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9544:PITHD1
gene id: 9544:PITHD1
uniprot id: F7CKL5
names: Similarity
messages: Belongs to the PITHD1 family.

9544:IDH2
gene id: 9544:IDH2
uniprot id: I0FRE5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9544:MGP
gene id: 9544:MGP
uniprot id: A0A8J8XU60
uniprot id: G7N6F0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9544:CUTA
gene id: 9544:CUTA
uniprot id: F6TPP3
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9544:E2F3
gene id: 9544:E2F3
uniprot id: A0A1D5QQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:TPM1
gene id: 9544:TPM1
uniprot id: A0A5K1UZR5
uniprot id: F7GV59
uniprot id: F7GV63
uniprot id: H9ELS7
uniprot id: I0FUQ5
uniprot id: I2CXK4
uniprot id: I2CXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:HK3
gene id: 9544:HK3
uniprot id: A0A8J8YD17
uniprot id: G7MU33
names: Similarity
messages: Belongs to the hexokinase family.

9544:SLC29A3
gene id: 9544:SLC29A3
uniprot id: F7HSE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9544:MRPL16
gene id: 9544:MRPL16
uniprot id: A0A1D5QG76
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9544:XRCC4
gene id: 9544:XRCC4
uniprot id: A0A5F7ZSH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9544:TAS2R10
gene id: 9544:TAS2R10
uniprot id: A0A5F7ZGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:ITGB1
gene id: 9544:ITGB1
uniprot id: F7EUS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9544:NQO1
gene id: 9544:NQO1
uniprot id: A0A1D5QSF4
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9544:YIPF3
gene id: 9544:YIPF3
uniprot id: A0A8J8YN40
uniprot id: F7FAC0
uniprot id: H9YVQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9544:TCP11L1
gene id: 9544:TCP11L1
uniprot id: A0A8J8YGN4
uniprot id: F6QCY5
names: Similarity
messages: Belongs to the TCP11 family.

9544:EXOC7
gene id: 9544:EXOC7
uniprot id: A0A5F7ZFP9
uniprot id: F7DT66
uniprot id: H9FRW4
uniprot id: H9FRW5
uniprot id: H9FRW6
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:PRPF31
gene id: 9544:PRPF31
uniprot id: A0A8J8XHU2
uniprot id: F6X6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9544:COPZ1
gene id: 9544:COPZ1
uniprot id: I0FQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9544:COPA
gene id: 9544:COPA
uniprot id: A0A8J8XWI1
uniprot id: G7ME70
uniprot id: H9FPZ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9544:ACTN1
gene id: 9544:ACTN1
uniprot id: A0A1D5QE04
uniprot id: H9YUP4
uniprot id: I0FW14
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:GNGT2
gene id: 9544:GNGT2
uniprot id: A0A8J8YHI8
uniprot id: F6PKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:CIRBP
gene id: 9544:CIRBP
uniprot id: I0FHP5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9544:INSL3
gene id: 9544:INSL3
uniprot id: D7RNQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

9544:SLC25A3
gene id: 9544:SLC25A3
uniprot id: A0A8J8Y412
uniprot id: F6VER2
uniprot id: I0FSL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SRF
gene id: 9544:SRF
uniprot id: H9YW01
names: Subcellular Location Annotation
messages: Nucleus

9544:SLCO2A1
gene id: 9544:SLCO2A1
uniprot id: A0A1D5Q5B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:OR4E2
gene id: 9544:OR4E2
uniprot id: A0A1D5QK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:EDN1
gene id: 9544:EDN1
uniprot id: A0A8J8XEF4
uniprot id: F7FGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9544:FXN
gene id: 9544:FXN
uniprot id: A0A1D5QYW7
names: Similarity
messages: Belongs to the frataxin family.

9544:ERLIN2
gene id: 9544:ERLIN2
uniprot id: A0A8J8XJB4
uniprot id: H9FPB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9544:NPY
gene id: 9544:NPY
uniprot id: A0A8J8YAR8
uniprot id: G7MLN4
uniprot id: Q9XSW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted
messages: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
messages: neuronal dense core vesicle

9544:SPINLW1
gene id: 9544:SPINLW1
uniprot id: Q9BDL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.
messages: Secreted
messages: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity).

9544:UTP11
gene id: 9544:UTP11
uniprot id: A0A8J8XU80
uniprot id: G7MFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9544:SUMO2
gene id: 9544:SUMO2
uniprot id: H9EN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9544:ILVBL
gene id: 9544:ILVBL
uniprot id: F6YYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9544:TRAM1L1
gene id: 9544:TRAM1L1
uniprot id: A0A8J8Y0E1
uniprot id: F7HQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9544:ETV3
gene id: 9544:ETV3
uniprot id: A0A5F8A5Y8
uniprot id: H9FR61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

9544:DNAJA1
gene id: 9544:DNAJA1
uniprot id: F7C2X2
names: Subcellular Location Annotation
messages: Membrane

9544:SHANK1
gene id: 9544:SHANK1
uniprot id: F7HHF0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

9544:TFRC
gene id: 9544:TFRC
uniprot id: F6UX47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9544:WNT9A
gene id: 9544:WNT9A
uniprot id: A0A1D5Q746
uniprot id: A0A5F8AIA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:PPT2
gene id: 9544:PPT2
uniprot id: A0A5F8APR1
uniprot id: F7HF28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9544:TIE1
gene id: 9544:TIE1
uniprot id: A0A8J8XCU7
uniprot id: G7MGE5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:UBLCP1
gene id: 9544:UBLCP1
uniprot id: F6VI02
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9544:VSX1
gene id: 9544:VSX1
uniprot id: A0A5F8A2B9
names: Subcellular Location Annotation
messages: Nucleus

9544:FXR2
gene id: 9544:FXR2
uniprot id: I0FHK9
names: Similarity
messages: Belongs to the FMR1 family.

9544:CRYBA2
gene id: 9544:CRYBA2
uniprot id: A0A8J8YGI6
uniprot id: F6RBJ4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:COX7AH
gene id: 9544:COX7AH
uniprot id: Q53CF7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9544:LIMK1
gene id: 9544:LIMK1
uniprot id: H9ESB9
uniprot id: H9H2W5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9544:CXCL16
gene id: 9544:CXCL16
uniprot id: F7AGQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Membrane

9544:CEP19
gene id: 9544:CEP19
uniprot id: A0A8J8XBW7
uniprot id: F7FWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9544:BCL2L14
gene id: 9544:BCL2L14
uniprot id: G7N676
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:SDHB
gene id: 9544:SDHB
uniprot id: F7GTK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9544:DNM1
gene id: 9544:DNM1
uniprot id: A0A1D5QVJ4
uniprot id: F6RXH1
uniprot id: F6S490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9544:DEDD
gene id: 9544:DEDD
uniprot id: A0A8J8XRQ1
uniprot id: F6UTR2
names: Subcellular Location Annotation
messages: nucleolus

9544:PKMYT1
gene id: 9544:PKMYT1
uniprot id: F6Z3J0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:AK2
gene id: 9544:AK2
uniprot id: A0A1D5QK39
uniprot id: A0A1D5RIB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9544:ANXA4
gene id: 9544:ANXA4
uniprot id: A0A1D5R5Q6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9544:TSC22D4
gene id: 9544:TSC22D4
uniprot id: H9G096
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9544:C3
gene id: 9544:C3
uniprot id: F7EV32
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9544:NEURL2
gene id: 9544:NEURL2
uniprot id: A0A8J8XDZ4
uniprot id: F6RBR9
names: Subcellular Location Annotation
messages: Cytoplasm

9544:YWHAB
gene id: 9544:YWHAB
uniprot id: F6XFG9
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:SLC2A11
gene id: 9544:SLC2A11
uniprot id: G8F1D3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9544:DNA2
gene id: 9544:DNA2
uniprot id: F7CAD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9544:NDUFV1
gene id: 9544:NDUFV1
uniprot id: G7NBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9544:CD209
gene id: 9544:CD209
uniprot id: Q95J96
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates. Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils.
messages: In vitro, is a receptor for HIV-1, HIV-2 and SIV and transmits viruses to permissive T-cells.
messages: Membrane
messages: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells (By similarity).
messages: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).

9544:MED22
gene id: 9544:MED22
uniprot id: A0A8J8XWE6
uniprot id: F6ZDB0
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9544:DLX3
gene id: 9544:DLX3
uniprot id: A0A8J8XGF2
uniprot id: F7HLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9544:TMEM258
gene id: 9544:TMEM258
uniprot id: F7H3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:NGF
gene id: 9544:NGF
uniprot id: F6T3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9544:FOXB2
gene id: 9544:FOXB2
uniprot id: F7DF65
names: Subcellular Location Annotation
messages: Nucleus

9544:HCRTR2
gene id: 9544:HCRTR2
uniprot id: A0A8J8XMM4
uniprot id: F7CZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:DYNC1H1
gene id: 9544:DYNC1H1
uniprot id: F6VUB3
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:ACAT2
gene id: 9544:ACAT2
uniprot id: F6TAZ6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9544:GCLC
gene id: 9544:GCLC
uniprot id: A0A1D5QEN7
uniprot id: A0A8J8Y0S5
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9544:EVX1
gene id: 9544:EVX1
uniprot id: A0A5F7ZK39
names: Subcellular Location Annotation
messages: Nucleus

9544:QPCT
gene id: 9544:QPCT
uniprot id: G7N9U7
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9544:INCENP
gene id: 9544:INCENP
uniprot id: A0A5F8A3R6
uniprot id: A0A5F8APE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9544:MAST3
gene id: 9544:MAST3
uniprot id: A0A5F7Z984
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:B4GALT1
gene id: 9544:B4GALT1
uniprot id: F6WPI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:PTMS
gene id: 9544:PTMS
uniprot id: H9FXQ3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:HOXD10
gene id: 9544:HOXD10
uniprot id: A0A1D5Q6N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:WNT3A
gene id: 9544:WNT3A
uniprot id: F7CJE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:NECAP2
gene id: 9544:NECAP2
uniprot id: A0A8J8XYM7
uniprot id: G7MH50
uniprot id: H9FWZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9544:CYP2A24
gene id: 9544:CYP2A24
uniprot id: Q6GUQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:FUT10
gene id: 9544:FUT10
uniprot id: A0A5F7ZTB9
uniprot id: F6S9A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9544:CPT2
gene id: 9544:CPT2
uniprot id: A0A8J8XFF7
uniprot id: H9FQ29
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9544:HNRNPH1
gene id: 9544:HNRNPH1
uniprot id: A0A1D5Q1E5
uniprot id: A0A1D5QN82
uniprot id: F7G3L4
names: Subcellular Location Annotation
messages: nucleoplasm

9544:PGAP3
gene id: 9544:PGAP3
uniprot id: F7B8U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9544:IL7
gene id: 9544:IL7
uniprot id: Q95J83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

9544:PHLDA3
gene id: 9544:PHLDA3
uniprot id: H9EPX0
names: Subcellular Location Annotation
messages: Cytoplasm

9544:SLC44A5
gene id: 9544:SLC44A5
uniprot id: A0A5F7ZY96
uniprot id: F7GW35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9544:B3GNT5
gene id: 9544:B3GNT5
uniprot id: A0A8J8XRB3
uniprot id: F6W1X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:ACAP2
gene id: 9544:ACAP2
uniprot id: A0A5F8AU18
uniprot id: H9EUG8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9544:GTF2F2
gene id: 9544:GTF2F2
uniprot id: H9ERZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9544:TOP2B
gene id: 9544:TOP2B
uniprot id: I2CT72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9544:EHD4
gene id: 9544:EHD4
uniprot id: F7HAE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9544:ALG14
gene id: 9544:ALG14
uniprot id: A0A5F8AFI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

9544:IFNA10
gene id: 9544:IFNA10
uniprot id: A0A5F8A6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:YY1
gene id: 9544:YY1
uniprot id: H9YYS6
names: Similarity
messages: Belongs to the YY transcription factor family.

9544:C1QA
gene id: 9544:C1QA
uniprot id: A0A3B0INW9
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9544:TJP2
gene id: 9544:TJP2
uniprot id: A0A5F7ZAY2
uniprot id: F7F8F4
uniprot id: F7GVN1
uniprot id: H9G212
uniprot id: H9G213
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:POU1F1
gene id: 9544:POU1F1
uniprot id: Q28503
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Altered in its ability to trans-activate compared to isoform B.
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

9544:PTGR2
gene id: 9544:PTGR2
uniprot id: A0A5F8ATW2
uniprot id: A0A8J8XW06
uniprot id: G7MYM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9544:SLC24A5
gene id: 9544:SLC24A5
uniprot id: F6ZB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9544:DDX18
gene id: 9544:DDX18
uniprot id: H9G1D5
uniprot id: I2CTC7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9544:BMP15
gene id: 9544:BMP15
uniprot id: A0A5F7ZM21
names: Similarity
messages: Belongs to the TGF-beta family.

9544:UBL3
gene id: 9544:UBL3
uniprot id: A0A8J8XFI4
uniprot id: G7NJV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:AKR7A2
gene id: 9544:AKR7A2
uniprot id: I2CY62
names: Subunit
messages: Monomer.

9544:CKB
gene id: 9544:CKB
uniprot id: I0FP16
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9544:DSTYK
gene id: 9544:DSTYK
uniprot id: Q20CR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm

9544:SLC30A1
gene id: 9544:SLC30A1
uniprot id: A0A5K1VRF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:ANO6
gene id: 9544:ANO6
uniprot id: A0A5F8ARY8
uniprot id: F7GVV8
uniprot id: G7N6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9544:MRPL20
gene id: 9544:MRPL20
uniprot id: A0A5F8A0J3
uniprot id: F7EZM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9544:DAPK2
gene id: 9544:DAPK2
uniprot id: A0A5F8A5R6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:SPATA18
gene id: 9544:SPATA18
uniprot id: F6YKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9544:MED23
gene id: 9544:MED23
uniprot id: A0A1D5QPU4
uniprot id: A0A1D5QXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9544:NDEL1
gene id: 9544:NDEL1
uniprot id: A0A5F8ASX0
uniprot id: F6UAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9544:NPC1L1
gene id: 9544:NPC1L1
uniprot id: A0MJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9544:KCNMB1
gene id: 9544:KCNMB1
uniprot id: A0A8J8Y6X7
uniprot id: F6ZEE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9544:HEXIM1
gene id: 9544:HEXIM1
uniprot id: A0A8J8Y2N7
uniprot id: F7BGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9544:TMEM63B
gene id: 9544:TMEM63B
uniprot id: A0A8J8YT21
uniprot id: G7MPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9544:UBIAD1
gene id: 9544:UBIAD1
uniprot id: A0A8J8Y0Q2
uniprot id: F7GJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9544:VPS45
gene id: 9544:VPS45
uniprot id: G7MDG6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:POU2F1
gene id: 9544:POU2F1
uniprot id: F7HE71
uniprot id: F7HE80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9544:ELP5
gene id: 9544:ELP5
uniprot id: F7CZW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9544:TMTC1
gene id: 9544:TMTC1
uniprot id: F7AG29
uniprot id: F7AGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9544:RBM47
gene id: 9544:RBM47
uniprot id: A0A5F8AS32
uniprot id: A0A8J8Y7I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9544:RBCK1
gene id: 9544:RBCK1
uniprot id: A0A5K1VSV4
uniprot id: F7F9X2
names: Similarity
messages: Belongs to the RBR family.

9544:RNPS1
gene id: 9544:RNPS1
uniprot id: F6QGS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9544:FAS
gene id: 9544:FAS
uniprot id: Q9BDP2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DAXX. Interacts with HIPK3 (By similarity). Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (By similarity). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity).
messages: Cell membrane
messages: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
messages: Membrane raft
messages: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.
messages: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).

9544:CLDN2
gene id: 9544:CLDN2
uniprot id: G7NSX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:LOC693506
gene id: 9544:LOC693506
uniprot id: H9H3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9544:CAPN10
gene id: 9544:CAPN10
uniprot id: A0A5K1V6E3
uniprot id: H9FPA8
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:FH
gene id: 9544:FH
uniprot id: F6VWV9
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9544:IGF1R
gene id: 9544:IGF1R
uniprot id: A0A8J8Y4S9
uniprot id: I2CWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:ACADSB
gene id: 9544:ACADSB
uniprot id: A0A8J8XYG7
uniprot id: G7N1B7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9544:ARSK
gene id: 9544:ARSK
uniprot id: F7DAA8
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:PRLHR
gene id: 9544:PRLHR
uniprot id: A0A5F8AHK6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:TNFSF15
gene id: 9544:TNFSF15
uniprot id: A0A8J8Y7Z5
uniprot id: F6S8F9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:NAPG
gene id: 9544:NAPG
uniprot id: H9ZEU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9544:NCF2
gene id: 9544:NCF2
uniprot id: A0A1D5Q5M3
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9544:LOC701223
gene id: 9544:LOC701223
uniprot id: H9FZC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9544:NAP1L4
gene id: 9544:NAP1L4
uniprot id: A0A5F8A9Q1
uniprot id: H9ERL2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:SNCB
gene id: 9544:SNCB
uniprot id: A0A8J8Y699
uniprot id: F7H5X2
names: Similarity
messages: Belongs to the synuclein family.

9544:LARP7
gene id: 9544:LARP7
uniprot id: H9FVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9544:EPHB1
gene id: 9544:EPHB1
uniprot id: A0A1D5QF63
uniprot id: A0A8J8XMR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9544:KEG06 p13
gene id: 9544:KEG06_p13
uniprot id: Q6IYH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9544:KDM4B
gene id: 9544:KDM4B
uniprot id: H9FRL4
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9544:ING1
gene id: 9544:ING1
uniprot id: F6UPA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:SLC7A14
gene id: 9544:SLC7A14
uniprot id: A0A8J8XU75
uniprot id: F6RYL9
names: Subcellular Location Annotation
messages: Membrane

9544:TRAPPC3
gene id: 9544:TRAPPC3
uniprot id: A0A1D5Q8B3
uniprot id: A0A8J8XK89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9544:NR3C2
gene id: 9544:NR3C2
uniprot id: A0A5F8ATS5
names: Subcellular Location Annotation
messages: Nucleus

9544:SNX13
gene id: 9544:SNX13
uniprot id: F6WJA8
names: Similarity
messages: Belongs to the sorting nexin family.

9544:CSH2
gene id: 9544:CSH2
uniprot id: Q07369
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9544:NOP2
gene id: 9544:NOP2
uniprot id: A0A1D5QF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9544:ATP6V1G1
gene id: 9544:ATP6V1G1
uniprot id: F6Z8T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:OSBP
gene id: 9544:OSBP
uniprot id: H9Z9F5
names: Similarity
messages: Belongs to the OSBP family.

9544:IVD
gene id: 9544:IVD
uniprot id: G7MWN5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9544:PDP1
gene id: 9544:PDP1
uniprot id: F6Q6N6
uniprot id: F6RX47
uniprot id: H9FW49
names: Similarity
messages: Belongs to the PP2C family.

9544:GALK1
gene id: 9544:GALK1
uniprot id: A0A5F7Z8J5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9544:TMCC3
gene id: 9544:TMCC3
uniprot id: A0A5F8APL4
names: Similarity
messages: Belongs to the TEX28 family.

9544:GAB2
gene id: 9544:GAB2
uniprot id: F6VIK2
names: Similarity
messages: Belongs to the GAB family.

9544:ATP6V1C2
gene id: 9544:ATP6V1C2
uniprot id: A0A5K1TYJ7
uniprot id: A0A8J8XEJ4
uniprot id: F6ZB76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9544:GBX1
gene id: 9544:GBX1
uniprot id: A0A1D5QDX9
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC701966
gene id: 9544:LOC701966
uniprot id: A0A5F7ZKR0
uniprot id: G7MZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9544:MARCKSL1
gene id: 9544:MARCKSL1
uniprot id: F6RIS3
names: Similarity
messages: Belongs to the MARCKS family.

9544:BCLAF1
gene id: 9544:BCLAF1
uniprot id: H9G2F8
uniprot id: H9G2F9
uniprot id: H9G2G0
uniprot id: H9ZFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCLAF1/THRAP3 family.
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

9544:CD163
gene id: 9544:CD163
uniprot id: G7N5V9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ARRDC2
gene id: 9544:ARRDC2
uniprot id: H9EVV3
names: Similarity
messages: Belongs to the arrestin family.

9544:NOXRED1
gene id: 9544:NOXRED1
uniprot id: A0A8J8XN37
uniprot id: F7FS22
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:GNG3
gene id: 9544:GNG3
uniprot id: A0A8J8XZF5
uniprot id: G7NCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:MASP1
gene id: 9544:MASP1
uniprot id: F7HR38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LYRM1
gene id: 9544:LYRM1
uniprot id: A0A8J8XL32
uniprot id: F7AIT7
names: Similarity
messages: Belongs to the complex I LYR family.

9544:CASP2
gene id: 9544:CASP2
uniprot id: A0A5F8ANV1
uniprot id: A0A8J8Y729
uniprot id: G7MN58
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:WNT9B
gene id: 9544:WNT9B
uniprot id: A0A5F7ZY04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:SLC43A2
gene id: 9544:SLC43A2
uniprot id: H9Z574
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

9544:MMP25
gene id: 9544:MMP25
uniprot id: F6YUR1
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:SEZ6
gene id: 9544:SEZ6
uniprot id: F7F6J3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:BANP
gene id: 9544:BANP
uniprot id: A0A5F8AJT1
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9544:HAL
gene id: 9544:HAL
uniprot id: F7H197
names: Similarity
messages: Belongs to the PAL/histidase family.

9544:OTUD7B
gene id: 9544:OTUD7B
uniprot id: A0A8J8Y7V2
uniprot id: F7BEE5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:USP4
gene id: 9544:USP4
uniprot id: G7MIM7
uniprot id: H9YWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9544:IWS1
gene id: 9544:IWS1
uniprot id: A0A5K1VQ97
uniprot id: G7NB48
names: Subcellular Location Annotation
messages: Nucleus

9544:PPP1CA
gene id: 9544:PPP1CA
uniprot id: F7GWK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9544:CPT1C
gene id: 9544:CPT1C
uniprot id: A0A5F8A9H3
uniprot id: A0A5K1V0V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:DDX3Y
gene id: 9544:DDX3Y
uniprot id: I0FW06
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:BRPF1
gene id: 9544:BRPF1
uniprot id: A0A1D5QY53
uniprot id: F7B679
uniprot id: G7MKS3
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC8A3
gene id: 9544:SLC8A3
uniprot id: A0A5F7ZQW5
uniprot id: A0A5F7ZTI2
uniprot id: F7HMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9544:GRPEL2
gene id: 9544:GRPEL2
uniprot id: F7F5I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9544:ATP5MC1
gene id: 9544:ATP5MC1
uniprot id: F6X104
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:MPP6
gene id: 9544:MPP6
uniprot id: A0A1D5R1Q9
uniprot id: F7CCP1
names: Similarity
messages: Belongs to the MAGUK family.

9544:PAFAH1B1
gene id: 9544:PAFAH1B1
uniprot id: F7AE78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9544:CETN2
gene id: 9544:CETN2
uniprot id: F7HT47
names: Similarity
messages: Belongs to the centrin family.

9544:SEC22C
gene id: 9544:SEC22C
uniprot id: F7HRR1
uniprot id: F7HTH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9544:RRP36
gene id: 9544:RRP36
uniprot id: A0A5F7ZZX0
uniprot id: A0A5F8A032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9544:TMEM53
gene id: 9544:TMEM53
uniprot id: G7MGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9544:UBE2E2
gene id: 9544:UBE2E2
uniprot id: A0A8J8XCC7
uniprot id: F7H5G8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:ROR1
gene id: 9544:ROR1
uniprot id: F6RUP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:IQSEC1
gene id: 9544:IQSEC1
uniprot id: A0A5F7Z7Z5
uniprot id: A0A5F7ZA09
uniprot id: A0A5F8AS01
uniprot id: G7MKP0
uniprot id: H9G2M8
names: Similarity
messages: Belongs to the BRAG family.

9544:CCNG2
gene id: 9544:CCNG2
uniprot id: G7MT04
uniprot id: H9ES29
names: Similarity
messages: Belongs to the cyclin family.

9544:CCN2
gene id: 9544:CCN2
uniprot id: H9FQD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MYORG
gene id: 9544:MYORG
uniprot id: I2CY75
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9544:TIPARP
gene id: 9544:TIPARP
uniprot id: A0A8J8YF55
uniprot id: F6USD8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:SEC61A1
gene id: 9544:SEC61A1
uniprot id: H9EML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:NKX2-4
gene id: 9544:NKX2-4
uniprot id: F6VYJ7
names: Subcellular Location Annotation
messages: Nucleus

9544:KRT2
gene id: 9544:KRT2
uniprot id: G7N727
names: Similarity
messages: Belongs to the intermediate filament family.

9544:NKX6-3
gene id: 9544:NKX6-3
uniprot id: G7MZ69
names: Subcellular Location Annotation
messages: Nucleus

9544:CTNNAL1
gene id: 9544:CTNNAL1
uniprot id: F6YZM1
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9544:CBWD1
gene id: 9544:CBWD1
uniprot id: H9FUN5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9544:CLDN25
gene id: 9544:CLDN25
uniprot id: A0A5F8AI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:CTSS
gene id: 9544:CTSS
uniprot id: A0A8J8XL63
uniprot id: G7MDI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9544:SMOC2
gene id: 9544:SMOC2
uniprot id: G7MR80
uniprot id: I0FU51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SYNPR
gene id: 9544:SYNPR
uniprot id: F7HAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9544:SEPTIN5
gene id: 9544:SEPTIN5
uniprot id: I0FSR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cytoskeleton

9544:HOXB7
gene id: 9544:HOXB7
uniprot id: F7HN76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:LHFPL6
gene id: 9544:LHFPL6
uniprot id: F7GID1
names: Subcellular Location Annotation
messages: Membrane

9544:CUTC
gene id: 9544:CUTC
uniprot id: H9EMJ1
names: Similarity
messages: Belongs to the CutC family.

9544:GSS
gene id: 9544:GSS
uniprot id: F7EMC7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9544:LOC100424026
gene id: 9544:LOC100424026
uniprot id: F7C481
names: Subcellular Location Annotation
messages: Membrane

9544:SEC13
gene id: 9544:SEC13
uniprot id: A0A8J8XUN4
uniprot id: F7GMC8
uniprot id: H9FYB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9544:DNAJA2
gene id: 9544:DNAJA2
uniprot id: A0A8J8XAS6
uniprot id: G7NP88
names: Subcellular Location Annotation
messages: Membrane

9544:PIGW
gene id: 9544:PIGW
uniprot id: A0A8J8Y843
uniprot id: F7HT11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9544:CADM2
gene id: 9544:CADM2
uniprot id: H9ENT6
names: Similarity
messages: Belongs to the nectin family.

9544:INMT
gene id: 9544:INMT
uniprot id: F7HSK5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9544:LYRM7
gene id: 9544:LYRM7
uniprot id: H9G1K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9544:LOC710110
gene id: 9544:LOC710110
uniprot id: A0A1D5R1V1
uniprot id: F6Y0X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9544:PRPF38B
gene id: 9544:PRPF38B
uniprot id: A0A8J8XX64
uniprot id: F6QPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9544:TMEM170B
gene id: 9544:TMEM170B
uniprot id: A0A8J8YBL8
uniprot id: F7HN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9544:DHDH
gene id: 9544:DHDH
uniprot id: H9EXM3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9544:UGT1A1
gene id: 9544:UGT1A1
uniprot id: Q95KM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:CILP
gene id: 9544:CILP
uniprot id: A0A8J8XKM4
uniprot id: F6YJ87
names: Subcellular Location Annotation
messages: extracellular matrix

9544:ATG4C
gene id: 9544:ATG4C
uniprot id: H9EUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9544:ATXN10
gene id: 9544:ATXN10
uniprot id: A0A1D5R2R8
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

9544:LOC709451
gene id: 9544:LOC709451
uniprot id: A0A5F8ADU9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:PRKCB
gene id: 9544:PRKCB
uniprot id: H9FX30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9544:UMPS
gene id: 9544:UMPS
uniprot id: H9EVX4
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9544:HENMT1
gene id: 9544:HENMT1
uniprot id: F7H0K7
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9544:MARS
gene id: 9544:MARS
uniprot id: H9YWI4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:SLCO1C1
gene id: 9544:SLCO1C1
uniprot id: A0A1D5QL08
uniprot id: A0A5K1VTR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:FUT11
gene id: 9544:FUT11
uniprot id: A0A1D5REL1
uniprot id: A0A8J8Y523
uniprot id: F6SBQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9544:ACTN2
gene id: 9544:ACTN2
uniprot id: F6VRJ5
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:LOC703700
gene id: 9544:LOC703700
uniprot id: H9EQ74
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:CCL5
gene id: 9544:CCL5
uniprot id: A0A8J8YNN5
uniprot id: A0MJX7
uniprot id: Q8HYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
messages: Secreted

9544:ANO4
gene id: 9544:ANO4
uniprot id: A0A8J8XB24
uniprot id: F6YBZ5
uniprot id: H9EPZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SCAMP4
gene id: 9544:SCAMP4
uniprot id: A0A1D5Q7S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:POLR3B
gene id: 9544:POLR3B
uniprot id: A0A8J8YNE0
uniprot id: F6WH42
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9544:EYA4
gene id: 9544:EYA4
uniprot id: F6SSQ1
uniprot id: F6TVK9
uniprot id: G7MQB9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9544:ZNF174
gene id: 9544:ZNF174
uniprot id: A0A8J8XU46
uniprot id: F6SZV8
names: Subcellular Location Annotation
messages: Nucleus

9544:NDUFS2
gene id: 9544:NDUFS2
uniprot id: H9FMK6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9544:GCNT7
gene id: 9544:GCNT7
uniprot id: F7GNQ8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:LOC702864
gene id: 9544:LOC702864
uniprot id: A0A1D5RIM1
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:MED4
gene id: 9544:MED4
uniprot id: A0A8J8XAY0
uniprot id: I2CU03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:GAS8
gene id: 9544:GAS8
uniprot id: H9FST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9544:EGR3
gene id: 9544:EGR3
uniprot id: F6RJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9544:NGB
gene id: 9544:NGB
uniprot id: H9ETU8
uniprot id: Q6WZ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).
messages: Monomer. Homodimer and homotetramer; disulfide-linked.
messages: Perikaryon

9544:PFN3
gene id: 9544:PFN3
uniprot id: A0A1D5QCM9
names: Similarity
messages: Belongs to the profilin family.

9544:CA11
gene id: 9544:CA11
uniprot id: A0A8J8YFL5
uniprot id: H9ER59
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9544:MCM7
gene id: 9544:MCM7
uniprot id: A0A8J8YIL7
uniprot id: H9FUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:SNX21
gene id: 9544:SNX21
uniprot id: F7DXI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9544:IL6
gene id: 9544:IL6
uniprot id: A0A1D5QRZ4
uniprot id: G7MLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9544:GAL3ST4
gene id: 9544:GAL3ST4
uniprot id: F7HJK8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9544:NGRN
gene id: 9544:NGRN
uniprot id: F6SRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9544:LOC697469
gene id: 9544:LOC697469
uniprot id: A0A1D5RH28
uniprot id: A0A8J8XC48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:BTG4
gene id: 9544:BTG4
uniprot id: F7EB61
names: Similarity
messages: Belongs to the BTG family.

9544:PBX3
gene id: 9544:PBX3
uniprot id: A0A5F8AK48
uniprot id: F6RF45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:RPL6
gene id: 9544:RPL6
uniprot id: F6WKH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9544:EIF5A
gene id: 9544:EIF5A
uniprot id: A0A1D5Q0G5
uniprot id: A0A8J8XQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ADGRL3
gene id: 9544:ADGRL3
uniprot id: F7HQJ6
names: Subcellular Location Annotation
messages: Membrane

9544:UNK
gene id: 9544:UNK
uniprot id: A0A8J8XEJ6
uniprot id: F7GKT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9544:CPN1
gene id: 9544:CPN1
uniprot id: F6XVC9
names: Similarity
messages: Belongs to the peptidase M14 family.

9544:DEF8
gene id: 9544:DEF8
uniprot id: F6X5P1
names: Similarity
messages: Belongs to the DEF8 family.

9544:LOC704609
gene id: 9544:LOC704609
uniprot id: A0A5F8AS41
names: Similarity
messages: Belongs to the actin family.

9544:RPL32
gene id: 9544:RPL32
uniprot id: F7B979
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9544:EIF5
gene id: 9544:EIF5
uniprot id: H9ESU3
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9544:MRPL17
gene id: 9544:MRPL17
uniprot id: A0A8J8XIP6
uniprot id: G7NE03
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9544:FGF5
gene id: 9544:FGF5
uniprot id: A0A8J8XPJ6
uniprot id: F7F301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9544:SCML1
gene id: 9544:SCML1
uniprot id: B0FZP2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SCM family.
messages: Expression is decreased in adult compared to sexually immature individuals.
messages: Highly expressed in testis and pancreas. Preferentially expressed in the germ stem cells of testis.
messages: Nucleus
messages: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).

9544:PPP1CC
gene id: 9544:PPP1CC
uniprot id: F7GFT6
uniprot id: H9YUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9544:LOC106995824
gene id: 9544:LOC106995824
uniprot id: I0FUI5
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9544:TNP1
gene id: 9544:TNP1
uniprot id: A0A8J8XN41
uniprot id: F7VJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9544:CPLX4
gene id: 9544:CPLX4
uniprot id: A0A8J8Y5D7
uniprot id: F6SS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9544:KIF21B
gene id: 9544:KIF21B
uniprot id: A0A1D5Q3G6
uniprot id: F6WVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9544:EPHB6
gene id: 9544:EPHB6
uniprot id: F7GJU4
names: Subcellular Location Annotation
messages: Membrane

9544:LOC711440
gene id: 9544:LOC711440
uniprot id: A0A1D5QHM1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:IL2
gene id: 9544:IL2
uniprot id: P68291
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9544:DPYSL5
gene id: 9544:DPYSL5
uniprot id: F6XU97
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9544:NPB
gene id: 9544:NPB
uniprot id: F6S922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9544:SRM
gene id: 9544:SRM
uniprot id: H9YZM0
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9544:NIPBL
gene id: 9544:NIPBL
uniprot id: F6XIX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9544:MPI
gene id: 9544:MPI
uniprot id: A0A1D5Q678
uniprot id: A0A8J8XMZ4
uniprot id: G7MYC5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9544:CNTNAP1
gene id: 9544:CNTNAP1
uniprot id: F7B7T3
uniprot id: F7HIS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9544:CAB39
gene id: 9544:CAB39
uniprot id: A0A8J8YTA7
uniprot id: F6Y0R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9544:RIOX2
gene id: 9544:RIOX2
uniprot id: A0A8J8YET6
uniprot id: F7DPH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

9544:ASIP
gene id: 9544:ASIP
uniprot id: A1YL67
uniprot id: G7N512
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9544:ISYNA1
gene id: 9544:ISYNA1
uniprot id: H9Z9U6
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

9544:AOX1
gene id: 9544:AOX1
uniprot id: M1ZMN0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9544:C13H2orf68
gene id: 9544:C13H2orf68
uniprot id: A0A8J8YBY0
uniprot id: G7NAJ1
names: Similarity
messages: Belongs to the UPF0561 family.

9544:SPRY1
gene id: 9544:SPRY1
uniprot id: A0A8J8YMA6
uniprot id: F7GQV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9544:LIX1
gene id: 9544:LIX1
uniprot id: A0A8J8YCX5
uniprot id: F7FWM1
names: Similarity
messages: Belongs to the LIX1 family.

9544:NDST3
gene id: 9544:NDST3
uniprot id: A0A8J8YQJ1
uniprot id: H9G1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9544:ANXA5
gene id: 9544:ANXA5
uniprot id: A0A5F8AR19
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9544:SIM2
gene id: 9544:SIM2
uniprot id: A0A5F8A9M5
names: Subcellular Location Annotation
messages: Nucleus

9544:NIPA1
gene id: 9544:NIPA1
uniprot id: F6VNT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9544:EXOG
gene id: 9544:EXOG
uniprot id: A0A5F8ALR3
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9544:ETNPPL
gene id: 9544:ETNPPL
uniprot id: G7MTL7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:DDI1
gene id: 9544:DDI1
uniprot id: A0A8J8YGZ5
uniprot id: F7GE01
names: Similarity
messages: Belongs to the DDI1 family.

9544:LOC696956
gene id: 9544:LOC696956
uniprot id: A0A5F8AMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:ABHD2
gene id: 9544:ABHD2
uniprot id: A0A8J8YNR2
uniprot id: G7MVW6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9544:UTP6
gene id: 9544:UTP6
uniprot id: A0A8J8YPM7
uniprot id: F6U7V6
names: Similarity
messages: Belongs to the UTP6 family.

9544:RDH11
gene id: 9544:RDH11
uniprot id: A0A8J8XYK8
uniprot id: H9Z9L2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:LIG3
gene id: 9544:LIG3
uniprot id: A0A8J8YG56
uniprot id: G7NGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9544:G6PC
gene id: 9544:G6PC
uniprot id: G7NIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9544:GCM1
gene id: 9544:GCM1
uniprot id: F7HNY3
names: Subcellular Location Annotation
messages: Nucleus

9544:SOD3
gene id: 9544:SOD3
uniprot id: F7H9D9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9544:NUP107
gene id: 9544:NUP107
uniprot id: F6PUD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9544:EBF2
gene id: 9544:EBF2
uniprot id: A0A8J8YRL5
uniprot id: F6W1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:IPPK
gene id: 9544:IPPK
uniprot id: A0A8J8XJE4
uniprot id: F6TD69
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9544:EXOSC3
gene id: 9544:EXOSC3
uniprot id: A0A1D5Q1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9544:CWF19L2
gene id: 9544:CWF19L2
uniprot id: F6ZHQ6
names: Similarity
messages: Belongs to the CWF19 family.

9544:RANBP10
gene id: 9544:RANBP10
uniprot id: I2CV23
names: Similarity
messages: Belongs to the RANBP9/10 family.

9544:HS2ST1
gene id: 9544:HS2ST1
uniprot id: A0A8J8XK52
uniprot id: H9G2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9544:SLC47A1
gene id: 9544:SLC47A1
uniprot id: A0A1D5RL11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9544:CALU
gene id: 9544:CALU
uniprot id: F6ZZ64
uniprot id: H9EN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9544:GRB7
gene id: 9544:GRB7
uniprot id: F7HC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9544:APLNR
gene id: 9544:APLNR
uniprot id: A0A8J8Y804
uniprot id: G7NDB4
uniprot id: O97666
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure.

9544:SH3GLB1
gene id: 9544:SH3GLB1
uniprot id: A0A1D5Q796
uniprot id: A0A1D5QE68
uniprot id: A0A8J8XBY1
uniprot id: F6ZLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9544:HGF
gene id: 9544:HGF
uniprot id: F7A5G3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9544:GUCY2C
gene id: 9544:GUCY2C
uniprot id: A0A5F8ATF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9544:B3GNT6
gene id: 9544:B3GNT6
uniprot id: A0A5F7ZRH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MTMR7
gene id: 9544:MTMR7
uniprot id: A0A8J8YCB2
uniprot id: F7GMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9544:CHURC1
gene id: 9544:CHURC1
uniprot id: A0A1D5RA12
names: Similarity
messages: Belongs to the Churchill family.

9544:ARL4D
gene id: 9544:ARL4D
uniprot id: A0A8J8XSY6
uniprot id: F6URI0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:NLRP1
gene id: 9544:NLRP1
uniprot id: B0FPF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NLRP family.
messages: Inflammasome
messages: cytosol

9544:HAPLN3
gene id: 9544:HAPLN3
uniprot id: F6ZXE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PLSCR3
gene id: 9544:PLSCR3
uniprot id: A0A8J8YKP9
uniprot id: F6U2A9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9544:SNRPD2
gene id: 9544:SNRPD2
uniprot id: H9Z0C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9544:RPS11
gene id: 9544:RPS11
uniprot id: F6T7U9
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9544:OGN
gene id: 9544:OGN
uniprot id: A0A8J8Y0H4
uniprot id: I0FLI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9544:ASB15
gene id: 9544:ASB15
uniprot id: F7BUA7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:SEMA7A
gene id: 9544:SEMA7A
uniprot id: H9G0X2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:FZR1
gene id: 9544:FZR1
uniprot id: A0A8J8YGB6
uniprot id: F7GTB6
uniprot id: G7NLU2
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9544:FAM92A
gene id: 9544:FAM92A
uniprot id: H9ERF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9544:GTF2H4
gene id: 9544:GTF2H4
uniprot id: A0A8J8YNV4
uniprot id: Q5TM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9544:TMEM237
gene id: 9544:TMEM237
uniprot id: H9FYM3
uniprot id: H9FYM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9544:TMEM86A
gene id: 9544:TMEM86A
uniprot id: H9EVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9544:ISCA1
gene id: 9544:ISCA1
uniprot id: H9ZE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9544:SLC10A3
gene id: 9544:SLC10A3
uniprot id: A0A5F8AQ95
uniprot id: A0A8J8XM23
uniprot id: F7FHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:SLC35D2
gene id: 9544:SLC35D2
uniprot id: F7HLK1
names: Subcellular Location Annotation
messages: Membrane

9544:BATF
gene id: 9544:BATF
uniprot id: H9Z3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9544:VPS37A
gene id: 9544:VPS37A
uniprot id: H9FQ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:TYROBP
gene id: 9544:TYROBP
uniprot id: A0A8J8XNR1
uniprot id: G7NMS6
uniprot id: Q8WNQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neuron…
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Following ligand binding by associated receptors, tyrosine phosphorylated in the ITAM domain which leads to activation of additional tyrosine kinases and subsequent cell activation.
messages: Homodimer; disulfide-linked (By similarity). Homotrimer; disulfide-linked (By similarity). Homotetramer; disulfide-linked (By similarity). Homotrimers and homotetramers form when low levels of partner receptors are available and is competitive with assembly with interacting receptors (By similarity). They may represent alternative oligomerization states or may be intermediates in the receptor assembly process (By similarity). Binding of a metal cation aids in homooligomerization through coordination of the metal ion by the subunits of the oligomer (By similarity). Interacts with TREM1 (By similarity). Interacts with TREM2 (By similarity). Interacts with CLECSF5 (By similarity). Interacts with CD300LB and CD300C2 (By similarity). Interacts with CD300E (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with KLRC2 (By similarity). Interacts with CD300H (By similarity). Interacts with KLRD1 (By similarity).
messages: Membrane

9544:LOC709712
gene id: 9544:LOC709712
uniprot id: A0A1D5R1T6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:RAB27B
gene id: 9544:RAB27B
uniprot id: A0A8J8Y904
uniprot id: F7E4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9544:TMEM106C
gene id: 9544:TMEM106C
uniprot id: A0A8J8XKR1
uniprot id: H9FZN1
names: Similarity
messages: Belongs to the TMEM106 family.

9544:LOC697857
gene id: 9544:LOC697857
uniprot id: A0A1D5RH28
uniprot id: A0A8J8XC48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ELMO1
gene id: 9544:ELMO1
uniprot id: A0A8J8Y783
uniprot id: F7DM33
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9544:ATP4B
gene id: 9544:ATP4B
uniprot id: A0A5F8AP74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:CSNK2A1
gene id: 9544:CSNK2A1
uniprot id: F7CKT2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:NDUFC2
gene id: 9544:NDUFC2
uniprot id: A0A8J8Y4Z7
uniprot id: F7HK78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9544:ZFPM2
gene id: 9544:ZFPM2
uniprot id: A0A8J8XAE5
uniprot id: G7MZX6
names: Subcellular Location Annotation
messages: Nucleus

9544:GOLPH3L
gene id: 9544:GOLPH3L
uniprot id: A0A5F7ZXM3
uniprot id: A0A8J8XPB3
uniprot id: F7B4L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9544:GUSBA
gene id: 9544:GUSBA
uniprot id: H9FTK4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9544:CNOT1
gene id: 9544:CNOT1
uniprot id: F7GNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9544:LOC100424965
gene id: 9544:LOC100424965
uniprot id: A0A5K1VME9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:SUFU
gene id: 9544:SUFU
uniprot id: H9EP79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9544:EZH2
gene id: 9544:EZH2
uniprot id: F6ZEX1
uniprot id: G7MN86
uniprot id: H9Z6A1
uniprot id: H9Z6A2
names: Subcellular Location Annotation
messages: Nucleus

9544:OR2J3
gene id: 9544:OR2J3
uniprot id: F7CCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:GNRHR2
gene id: 9544:GNRHR2
uniprot id: Q95JG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Phosphorylated on the C-terminal cytoplasmic tail.
messages: Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:BTF3
gene id: 9544:BTF3
uniprot id: G7MQL9
uniprot id: I0FHT3
names: Similarity
messages: Belongs to the NAC-beta family.

9544:SNAP23
gene id: 9544:SNAP23
uniprot id: A0A1D5QYR9
uniprot id: A0A8J8Y055
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9544:TAF4B
gene id: 9544:TAF4B
uniprot id: F7FQ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9544:RSRP1
gene id: 9544:RSRP1
uniprot id: I0FTL6
names: Similarity
messages: Belongs to the RSRP family.

9544:IFT46
gene id: 9544:IFT46
uniprot id: A0A8J8Y8V2
uniprot id: G7NCC8
uniprot id: H9ESL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9544:SNRPD1
gene id: 9544:SNRPD1
uniprot id: H9ZCP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9544:LOC710545
gene id: 9544:LOC710545
uniprot id: A7E3J4
names: Subcellular Location Annotation
messages: Nucleus

9544:NDST1
gene id: 9544:NDST1
uniprot id: F7GSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9544:GPM6B
gene id: 9544:GPM6B
uniprot id: A0A1D5RHL7
uniprot id: A0A5F8ARV6
uniprot id: A0A8J8XQP0
uniprot id: F6RG95
uniprot id: G7MKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9544:AMIGO3
gene id: 9544:AMIGO3
uniprot id: F7GRK0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9544:GINS4
gene id: 9544:GINS4
uniprot id: A0A8J8YSV6
uniprot id: F7E9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9544:LOC717993
gene id: 9544:LOC717993
uniprot id: G7MDQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9544:CCT2
gene id: 9544:CCT2
uniprot id: I0FNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:CASP9
gene id: 9544:CASP9
uniprot id: I0FVL9
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:BCAS2
gene id: 9544:BCAS2
uniprot id: I2CYF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9544:IP6K1
gene id: 9544:IP6K1
uniprot id: A0A8J8YPV5
uniprot id: F7GRE2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9544:SLC4A8
gene id: 9544:SLC4A8
uniprot id: F7HME6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9544:GRHL2
gene id: 9544:GRHL2
uniprot id: F7HKR5
names: Subcellular Location Annotation
messages: Nucleus

9544:NIPSNAP2
gene id: 9544:NIPSNAP2
uniprot id: I2CWV1
names: Similarity
messages: Belongs to the NipSnap family.

9544:MVD
gene id: 9544:MVD
uniprot id: F7D4H8
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9544:IFI27
gene id: 9544:IFI27
uniprot id: Q6IEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9544:NUPR1
gene id: 9544:NUPR1
uniprot id: G7NQH3
uniprot id: H9FSV6
names: Similarity
messages: Belongs to the NUPR family.

9544:TRMT6
gene id: 9544:TRMT6
uniprot id: A0A8J8YC52
uniprot id: F6RWA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9544:CLASP1
gene id: 9544:CLASP1
uniprot id: F6QKC2
uniprot id: H9FRZ4
uniprot id: I0FQA8
uniprot id: I0FQA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

9544:KBTBD8
gene id: 9544:KBTBD8
uniprot id: F6ZJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9544:SPATA6
gene id: 9544:SPATA6
uniprot id: F7H5Z0
names: Similarity
messages: Belongs to the SPATA6 family.

9544:CLVS2
gene id: 9544:CLVS2
uniprot id: A0A8J8YA01
uniprot id: F7EDV5
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9544:FAM98A
gene id: 9544:FAM98A
uniprot id: F7BNZ9
names: Similarity
messages: Belongs to the FAM98 family.

9544:OTULIN
gene id: 9544:OTULIN
uniprot id: A0A5F8ABU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9544:ATP1A4
gene id: 9544:ATP1A4
uniprot id: A0A8J8YDU7
uniprot id: F7DQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9544:KDM3B
gene id: 9544:KDM3B
uniprot id: I0FSK5
names: Subcellular Location Annotation
messages: Nucleus

9544:NDRG2
gene id: 9544:NDRG2
uniprot id: H9YYM8
uniprot id: I2CY02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

9544:P2RX3
gene id: 9544:P2RX3
uniprot id: A0A1D5QSM7
uniprot id: A0A8J8XQL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9544:EXOC4
gene id: 9544:EXOC4
uniprot id: A0A8J8XZQ0
uniprot id: G7MME5
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:CLDND2
gene id: 9544:CLDND2
uniprot id: A0A5F7ZNN9
uniprot id: A0A5F8A8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9544:PSMC3
gene id: 9544:PSMC3
uniprot id: H9Z3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9544:C20H16orf70
gene id: 9544:C20H16orf70
uniprot id: A0A8J8XCQ3
uniprot id: F7EFR6
names: Similarity
messages: Belongs to the PHAF1 family.

9544:LPCAT3
gene id: 9544:LPCAT3
uniprot id: A0A8J8YKW5
uniprot id: G7N5U7
names: Subcellular Location Annotation
messages: Membrane

9544:KCNJ4
gene id: 9544:KCNJ4
uniprot id: A0A1D5RE55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:VPS37D
gene id: 9544:VPS37D
uniprot id: I0FPI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9544:PTPRN2
gene id: 9544:PTPRN2
uniprot id: F6UWH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9544:GGT7
gene id: 9544:GGT7
uniprot id: F7ERT0
uniprot id: H9ETE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9544:TNRC6B
gene id: 9544:TNRC6B
uniprot id: F6XNN3
names: Similarity
messages: Belongs to the GW182 family.

9544:MON2
gene id: 9544:MON2
uniprot id: F6WNT8
uniprot id: H9FRL8
names: Similarity
messages: Belongs to the MON2 family.

9544:POPDC3
gene id: 9544:POPDC3
uniprot id: A0A8J8XWB6
uniprot id: F7GJR7
names: Similarity
messages: Belongs to the popeye family.

9544:SLC16A12
gene id: 9544:SLC16A12
uniprot id: F6UMB1
names: Subcellular Location Annotation
messages: Membrane

9544:HDAC2
gene id: 9544:HDAC2
uniprot id: H9EPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9544:TPK1
gene id: 9544:TPK1
uniprot id: A0A8J8YSB2
uniprot id: F7F874
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9544:EGFL7
gene id: 9544:EGFL7
uniprot id: F7GSK3
uniprot id: H9FVA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CXCL14
gene id: 9544:CXCL14
uniprot id: H9EQH7
names: Subcellular Location Annotation
messages: Secreted

9544:DOCK9
gene id: 9544:DOCK9
uniprot id: F6ZZG2
uniprot id: F7A5B2
names: Similarity
messages: Belongs to the DOCK family.

9544:COQ10B
gene id: 9544:COQ10B
uniprot id: A0A8J8YDJ4
uniprot id: F7BGC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9544:RNF39
gene id: 9544:RNF39
uniprot id: Q5TM52
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in prolonged long term-potentiation (LTP) maintenance.

9544:LOC695657
gene id: 9544:LOC695657
uniprot id: G7MR19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MED18
gene id: 9544:MED18
uniprot id: A0A8J8XLQ3
uniprot id: F6R857
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:PI4K2A
gene id: 9544:PI4K2A
uniprot id: A0A1D5QJT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9544:UBL4A
gene id: 9544:UBL4A
uniprot id: F7GKS2
names: Subcellular Location Annotation
messages: cytosol

9544:SNX25
gene id: 9544:SNX25
uniprot id: F7HJ42
names: Similarity
messages: Belongs to the sorting nexin family.

9544:LPAR4
gene id: 9544:LPAR4
uniprot id: A0A8J8YBY8
uniprot id: F7B7B1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:LOC706824
gene id: 9544:LOC706824
uniprot id: F6TKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PNRC2
gene id: 9544:PNRC2
uniprot id: A0A8J8XPT9
uniprot id: F6PZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9544:CDNF
gene id: 9544:CDNF
uniprot id: A0A8J8YJG9
uniprot id: F7GYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9544:POLR3G
gene id: 9544:POLR3G
uniprot id: F6Y5L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:PRKAR2B
gene id: 9544:PRKAR2B
uniprot id: F6Q503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9544:ADSL
gene id: 9544:ADSL
uniprot id: H9Z5Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9544:MVB12B
gene id: 9544:MVB12B
uniprot id: A0A5K1UCN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:LOC706619
gene id: 9544:LOC706619
uniprot id: F7E896
uniprot id: H9FZ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9544:LOC711104
gene id: 9544:LOC711104
uniprot id: A0A1D5QI76
uniprot id: A0A1D5R338
names: Similarity
messages: Belongs to the Luc7 family.

9544:CASTOR2
gene id: 9544:CASTOR2
uniprot id: H9ZD32
names: Similarity
messages: Belongs to the GATS family.

9544:ADPRH
gene id: 9544:ADPRH
uniprot id: F6REF0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9544:DDX27
gene id: 9544:DDX27
uniprot id: G7N4K8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:FAHD1
gene id: 9544:FAHD1
uniprot id: H9ESY3
names: Similarity
messages: Belongs to the FAH family.

9544:TMEM39B
gene id: 9544:TMEM39B
uniprot id: F6RKY8
uniprot id: F7GNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9544:GATM
gene id: 9544:GATM
uniprot id: G7MX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9544:SENP5
gene id: 9544:SENP5
uniprot id: A0A5K1USX2
uniprot id: A0A8J8XMH2
uniprot id: G7MKG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9544:HIP1R
gene id: 9544:HIP1R
uniprot id: H9G1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

9544:AADACL2
gene id: 9544:AADACL2
uniprot id: A0A8J8XMD3
uniprot id: F6ZWT8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:HTR1B
gene id: 9544:HTR1B
uniprot id: A0A8J8XEK3
uniprot id: F6SFA9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9544:IER3IP1
gene id: 9544:IER3IP1
uniprot id: H9FV94
names: Similarity
messages: Belongs to the YOS1 family.

9544:ARSD
gene id: 9544:ARSD
uniprot id: H9H4P4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:PMPCA
gene id: 9544:PMPCA
uniprot id: I2CYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9544:CDH6
gene id: 9544:CDH6
uniprot id: G7MUQ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:PRKCD
gene id: 9544:PRKCD
uniprot id: H9EU39
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9544:RPL31
gene id: 9544:RPL31
uniprot id: A0A8J8YHV2
uniprot id: G7NGF5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9544:NDUFA10
gene id: 9544:NDUFA10
uniprot id: H9FML1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9544:IL15
gene id: 9544:IL15
uniprot id: P48092
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
messages: Secreted

9544:IL2RA
gene id: 9544:IL2RA
uniprot id: Q5MNY4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9544:RRP8
gene id: 9544:RRP8
uniprot id: A0A8J8XMA3
uniprot id: F7C3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9544:TGFBR2
gene id: 9544:TGFBR2
uniprot id: F6Q1B1
uniprot id: H9YUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9544:CSTB
gene id: 9544:CSTB
uniprot id: H9EXJ7
names: Similarity
messages: Belongs to the cystatin family.

9544:WSCD1
gene id: 9544:WSCD1
uniprot id: F6QL12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9544:CACHD1
gene id: 9544:CACHD1
uniprot id: F6SSN2
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9544:TMEM230
gene id: 9544:TMEM230
uniprot id: F6R010
uniprot id: F6ZD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9544:FBP2
gene id: 9544:FBP2
uniprot id: A0A5F7ZFX7
uniprot id: F6YGD4
names: Similarity
messages: Belongs to the FBPase class 1 family.

9544:HACD4
gene id: 9544:HACD4
uniprot id: A0A5F8A121
uniprot id: A0A8J8Y1D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PITPNM1
gene id: 9544:PITPNM1
uniprot id: F7H788
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9544:MAX
gene id: 9544:MAX
uniprot id: A0A8J8XCA4
uniprot id: F6XM92
uniprot id: F7FVQ8
names: Similarity
messages: Belongs to the MAX family.

9544:SATB1
gene id: 9544:SATB1
uniprot id: F6XW50
uniprot id: I2CY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:GCNT2
gene id: 9544:GCNT2
uniprot id: F6Z9P4
uniprot id: G7MQJ9
uniprot id: H9H454
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:F3
gene id: 9544:F3
uniprot id: H9FR67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9544:SHH
gene id: 9544:SHH
uniprot id: A0A5F7ZJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9544:CCT6A
gene id: 9544:CCT6A
uniprot id: H9G1L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:CLEC12B
gene id: 9544:CLEC12B
uniprot id: G7N642
uniprot id: I2CVJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PXMP2
gene id: 9544:PXMP2
uniprot id: F6QAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9544:SLC22A12
gene id: 9544:SLC22A12
uniprot id: I7HH13
names: Subcellular Location Annotation
messages: Membrane

9544:YRDC
gene id: 9544:YRDC
uniprot id: F7GUN2
names: Similarity
messages: Belongs to the SUA5 family.

9544:BLOC1S5
gene id: 9544:BLOC1S5
uniprot id: A0A5F8A7F4
uniprot id: F7E4G5
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9544:TSPAN18
gene id: 9544:TSPAN18
uniprot id: F6YG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:POLR2E
gene id: 9544:POLR2E
uniprot id: I2CYA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9544:SOAT2
gene id: 9544:SOAT2
uniprot id: F6RU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:SLC2A1
gene id: 9544:SLC2A1
uniprot id: F6YFI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Photoreceptor inner segment

9544:CLP1
gene id: 9544:CLP1
uniprot id: A0A8J8YRC7
uniprot id: F6QNV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9544:SLCO6A1
gene id: 9544:SLCO6A1
uniprot id: A0A1D5R3U6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:EMC4
gene id: 9544:EMC4
uniprot id: A0A5F8AS46
uniprot id: A0A8J8XL35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CALCB
gene id: 9544:CALCB
uniprot id: A0A8J8XY27
uniprot id: F6US88
names: Similarity
messages: Belongs to the calcitonin family.

9544:OXSR1
gene id: 9544:OXSR1
uniprot id: A0A1D5R0F4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9544:SLC25A11
gene id: 9544:SLC25A11
uniprot id: H9ZE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:NT5C3B
gene id: 9544:NT5C3B
uniprot id: H9EV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9544:UCK1
gene id: 9544:UCK1
uniprot id: A0A1D5R0F2
names: Similarity
messages: Belongs to the uridine kinase family.

9544:LOC715795
gene id: 9544:LOC715795
uniprot id: A0A5F8AN82
uniprot id: F7GQZ4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9544:STX12
gene id: 9544:STX12
uniprot id: F7GMG0
uniprot id: H9Z784
names: Similarity
messages: Belongs to the syntaxin family.

9544:CSNK1G2
gene id: 9544:CSNK1G2
uniprot id: H9EP27
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9544:STX4
gene id: 9544:STX4
uniprot id: A0A8J8Y4H7
uniprot id: G7NQX9
names: Similarity
messages: Belongs to the syntaxin family.

9544:ACAP3
gene id: 9544:ACAP3
uniprot id: I0FP30
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9544:GET4
gene id: 9544:GET4
uniprot id: H9FVN4
names: Similarity
messages: Belongs to the GET4 family.

9544:GABRB1
gene id: 9544:GABRB1
uniprot id: A0A8J8YAF6
uniprot id: G7MSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:GALNT17
gene id: 9544:GALNT17
uniprot id: F6Y9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:WDR76
gene id: 9544:WDR76
uniprot id: F7G8Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9544:TMEM233
gene id: 9544:TMEM233
uniprot id: A0A5F8ANU8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:RPL11
gene id: 9544:RPL11
uniprot id: F6PJ30
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9544:OS9
gene id: 9544:OS9
uniprot id: F6PTF4
uniprot id: F6PU01
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9544:ANAPC11
gene id: 9544:ANAPC11
uniprot id: H9FVK9
names: Similarity
messages: Belongs to the RING-box family.

9544:GMPPA
gene id: 9544:GMPPA
uniprot id: A0A1D5QED6
uniprot id: A0A5F8ALN4
uniprot id: A0A8J8XUV2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9544:EYA1
gene id: 9544:EYA1
uniprot id: F6SSJ2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9544:LOC704659
gene id: 9544:LOC704659
uniprot id: G7MN45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:ACVR1B
gene id: 9544:ACVR1B
uniprot id: I2CYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:NR1I3
gene id: 9544:NR1I3
uniprot id: Q8MIM3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).
messages: Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
messages: Cytoplasm
messages: Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Nucleus
messages: Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
messages: cytoskeleton

9544:LAP3
gene id: 9544:LAP3
uniprot id: F6TQJ2
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9544:KCNA10
gene id: 9544:KCNA10
uniprot id: F7HL26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PTGES
gene id: 9544:PTGES
uniprot id: A0A8J8YEY0
uniprot id: G7NFJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9544:ING2
gene id: 9544:ING2
uniprot id: H9Z017
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:RBM22
gene id: 9544:RBM22
uniprot id: F6PL59
names: Similarity
messages: Belongs to the SLT11 family.

9544:EGR2
gene id: 9544:EGR2
uniprot id: A0A8J8XBH1
uniprot id: G7N2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9544:SLC16A5
gene id: 9544:SLC16A5
uniprot id: A0A8J8XR62
uniprot id: G7NGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9544:GCG
gene id: 9544:GCG
uniprot id: A0A5F8A440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9544:ETV5
gene id: 9544:ETV5
uniprot id: A0A8J8XAL8
uniprot id: G7MJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:PRKDC
gene id: 9544:PRKDC
uniprot id: F6SNY4
uniprot id: F6SP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: nucleolus

9544:ACTR3
gene id: 9544:ACTR3
uniprot id: H9FNE9
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9544:CDCA8
gene id: 9544:CDCA8
uniprot id: A0A8J8YGZ0
uniprot id: F7CYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9544:HNRNPA2B1
gene id: 9544:HNRNPA2B1
uniprot id: I2CYL4
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9544:MRPL32
gene id: 9544:MRPL32
uniprot id: A0A5F7ZKH0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9544:AMPD1
gene id: 9544:AMPD1
uniprot id: F6VAM7
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9544:MPP4
gene id: 9544:MPP4
uniprot id: F7F2M2
names: Similarity
messages: Belongs to the MAGUK family.

9544:BOP1
gene id: 9544:BOP1
uniprot id: F7GBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9544:CCL23
gene id: 9544:CCL23
uniprot id: Q8HYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted
messages: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity).

9544:PEX10
gene id: 9544:PEX10
uniprot id: F7ENR8
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9544:TMEM211
gene id: 9544:TMEM211
uniprot id: F6SSC5
names: Subcellular Location Annotation
messages: Membrane

9544:AACS
gene id: 9544:AACS
uniprot id: I0FH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

9544:C14H11orf49
gene id: 9544:C14H11orf49
uniprot id: F6SZL4
uniprot id: H9YW91
uniprot id: H9YW92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9544:ELOVL2
gene id: 9544:ELOVL2
uniprot id: A0A1D5QUB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9544:CTSK
gene id: 9544:CTSK
uniprot id: A0A8J8YGW4
uniprot id: G7MDI3
uniprot id: P61277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9544:POLR2B
gene id: 9544:POLR2B
uniprot id: F6QI47
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9544:LCAT
gene id: 9544:LCAT
uniprot id: G7NQ76
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:COQ3
gene id: 9544:COQ3
uniprot id: A0A5F8A0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9544:CAMK2D
gene id: 9544:CAMK2D
uniprot id: A0A1D5QEN3
uniprot id: F6UGY3
uniprot id: F7H4F4
uniprot id: H9G098
uniprot id: H9ZE08
uniprot id: H9ZE10
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:RPGRIP1L
gene id: 9544:RPGRIP1L
uniprot id: H9FRZ1
names: Similarity
messages: Belongs to the RPGRIP1 family.

9544:CREBBP
gene id: 9544:CREBBP
uniprot id: A0A5F7ZKK8
uniprot id: A0A5F8ARC8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ZNF397
gene id: 9544:ZNF397
uniprot id: A0A8J8YH71
uniprot id: F7AE32
names: Subcellular Location Annotation
messages: Nucleus

9544:MEAF6
gene id: 9544:MEAF6
uniprot id: A0A5K1U4P9
uniprot id: F7GRW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9544:NXPH2
gene id: 9544:NXPH2
uniprot id: A0A1D5Q591
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:LOC711174
gene id: 9544:LOC711174
uniprot id: A0A8J8XY78
uniprot id: F7GNB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9544:SS18L2
gene id: 9544:SS18L2
uniprot id: H9FVB5
names: Similarity
messages: Belongs to the SS18 family.

9544:RPL3
gene id: 9544:RPL3
uniprot id: A0A5F8AHB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9544:SRXN1
gene id: 9544:SRXN1
uniprot id: F7H9B2
names: Similarity
messages: Belongs to the sulfiredoxin family.

9544:MRPS18B
gene id: 9544:MRPS18B
uniprot id: A0A5S7WSP6
uniprot id: H9EXU2
uniprot id: Q5TM62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9544:GTF2E2
gene id: 9544:GTF2E2
uniprot id: A0A8J8XJ30
uniprot id: G7N0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9544:MELK
gene id: 9544:MELK
uniprot id: H9Z026
uniprot id: I2CVB0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9544:FSCN3
gene id: 9544:FSCN3
uniprot id: G7MMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9544:STAT5A
gene id: 9544:STAT5A
uniprot id: A0A1D5QPR1
uniprot id: F7G8V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:SYT2
gene id: 9544:SYT2
uniprot id: A0A8J8XZU9
uniprot id: F6XQZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9544:RPL37A
gene id: 9544:RPL37A
uniprot id: F7CQW3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9544:PARG
gene id: 9544:PARG
uniprot id: H9EV41
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9544:FCF1
gene id: 9544:FCF1
uniprot id: H9FV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9544:TGFBR1
gene id: 9544:TGFBR1
uniprot id: F7H0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:ASAH2
gene id: 9544:ASAH2
uniprot id: A0A8J8YN52
uniprot id: F7ESF6
names: Similarity
messages: Belongs to the neutral ceramidase family.

9544:TAF11
gene id: 9544:TAF11
uniprot id: A0A1D5QA17
uniprot id: A0A8J8Y7D5
names: Similarity
messages: Belongs to the TAF11 family.

9544:CYHYorf15B
gene id: 9544:CYHYorf15B
uniprot id: C0KZ98
names: Similarity
messages: Belongs to the taxilin family.

9544:ATP6V0E1
gene id: 9544:ATP6V0E1
uniprot id: A0A8J8XT11
uniprot id: H9ERW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:PRCP
gene id: 9544:PRCP
uniprot id: I0FJ27
names: Similarity
messages: Belongs to the peptidase S28 family.

9544:LOC707129
gene id: 9544:LOC707129
uniprot id: F7A635
names: Similarity
messages: Belongs to the intermediate filament family.

9544:SLC35F1
gene id: 9544:SLC35F1
uniprot id: F6ZBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9544:LOC106995404
gene id: 9544:LOC106995404
uniprot id: A0A5F8AA24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:LPAR6
gene id: 9544:LPAR6
uniprot id: F7AZM0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:NIPSNAP1
gene id: 9544:NIPSNAP1
uniprot id: H9G114
names: Similarity
messages: Belongs to the NipSnap family.

9544:FAM20A
gene id: 9544:FAM20A
uniprot id: A0A5F7ZMN7
uniprot id: F6WFV9
names: Similarity
messages: Belongs to the FAM20 family.

9544:SPACA4
gene id: 9544:SPACA4
uniprot id: F7H350
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9544:HIST1H3D
gene id: 9544:HIST1H3D
uniprot id: A0A8J8Y153
uniprot id: F7BRX2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SMARCD3
gene id: 9544:SMARCD3
uniprot id: F7H1V3
uniprot id: I0FGW3
uniprot id: I0FGW4
names: Similarity
messages: Belongs to the SMARCD family.

9544:SLC25A31
gene id: 9544:SLC25A31
uniprot id: A0A8J8XRI5
uniprot id: F6VUM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:CLEC18A
gene id: 9544:CLEC18A
uniprot id: F6X9G0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ELF3
gene id: 9544:ELF3
uniprot id: F6TYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:NR0B2
gene id: 9544:NR0B2
uniprot id: A0A8J8XNV1
uniprot id: F6T9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9544:FAM133A
gene id: 9544:FAM133A
uniprot id: A0A8J8Y5R2
uniprot id: F6X6G4
names: Similarity
messages: Belongs to the FAM133 family.

9544:PTPN4
gene id: 9544:PTPN4
uniprot id: F6WK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9544:NDRG1
gene id: 9544:NDRG1
uniprot id: F6SHZ8
uniprot id: F6SI55
names: Similarity
messages: Belongs to the NDRG family.

9544:CHN2
gene id: 9544:CHN2
uniprot id: A0A1D5QMR4
uniprot id: F6VWF7
uniprot id: H9ETX3
names: Function
messages: GTPase-activating protein for p21-rac.

9544:MED1
gene id: 9544:MED1
uniprot id: H9FW47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9544:NSG1
gene id: 9544:NSG1
uniprot id: A0A8J8XQV1
uniprot id: F6WLM4
names: Similarity
messages: Belongs to the NSG family.

9544:COX10
gene id: 9544:COX10
uniprot id: A0A5F8AR90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9544:TTC21B
gene id: 9544:TTC21B
uniprot id: A0A5F8AM29
names: Similarity
messages: Belongs to the TTC21 family.

9544:MAGOH
gene id: 9544:MAGOH
uniprot id: A0A8J8Y1M5
uniprot id: H9FUG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9544:UST
gene id: 9544:UST
uniprot id: H9EUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9544:UHRF2
gene id: 9544:UHRF2
uniprot id: A0A5F8ASM0
uniprot id: H9ET07
names: Subcellular Location Annotation
messages: Nucleus

9544:PNO1
gene id: 9544:PNO1
uniprot id: Q7YRC8
names: Similarity
messages: Belongs to the PNO1 family.

9544:PHF1
gene id: 9544:PHF1
uniprot id: A0A1D5R364
uniprot id: A0A8J8YP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:IFI6
gene id: 9544:IFI6
uniprot id: Q6IEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9544:CMC2
gene id: 9544:CMC2
uniprot id: G7NR49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9544:REEP4
gene id: 9544:REEP4
uniprot id: A0A8J8YKS7
uniprot id: F7HAD1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:STARD5
gene id: 9544:STARD5
uniprot id: A0A5F8A100
uniprot id: A0A8J8Y1S3
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9544:THBD
gene id: 9544:THBD
uniprot id: A0A8J8YEP9
uniprot id: G7N337
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9544:GPX8
gene id: 9544:GPX8
uniprot id: G7MTR3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9544:RNASE10
gene id: 9544:RNASE10
uniprot id: A0A8J8YLP3
uniprot id: F6T0X8
uniprot id: W0UTD5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:B4GALT5
gene id: 9544:B4GALT5
uniprot id: I0FLN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:PSAP
gene id: 9544:PSAP
uniprot id: F7GVI7
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9544:TMSB15A
gene id: 9544:TMSB15A
uniprot id: A0A8J8YHD8
uniprot id: H9FTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:SLC41A2
gene id: 9544:SLC41A2
uniprot id: A0A8J8XKV4
uniprot id: F7H2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9544:SPON1
gene id: 9544:SPON1
uniprot id: A0A8J8XDP1
uniprot id: H9EU02
names: Subcellular Location Annotation
messages: extracellular matrix

9544:GLOD4
gene id: 9544:GLOD4
uniprot id: H9EV69
names: Similarity
messages: Belongs to the glyoxalase I family.

9544:ARHGEF12
gene id: 9544:ARHGEF12
uniprot id: A0A1D5R2Y9
uniprot id: A0A5F8ARW5
uniprot id: F6UZH5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9544:PSMD9
gene id: 9544:PSMD9
uniprot id: G7N617
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9544:UBA52
gene id: 9544:UBA52
uniprot id: F7GN03
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9544:MCM4
gene id: 9544:MCM4
uniprot id: A0A8J8XHP0
uniprot id: G7MZ95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:FAM163B
gene id: 9544:FAM163B
uniprot id: A0A8J8XAE4
uniprot id: F7HGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9544:LCN6
gene id: 9544:LCN6
uniprot id: P62503
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: May play a role in male fertility.
messages: Secreted

9544:PPP1R14C
gene id: 9544:PPP1R14C
uniprot id: F7H817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9544:KCNQ5
gene id: 9544:KCNQ5
uniprot id: F6Q5R2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TMEM120A
gene id: 9544:TMEM120A
uniprot id: I0FVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9544:BAIAP2
gene id: 9544:BAIAP2
uniprot id: H9ERK7
uniprot id: H9ERP2
uniprot id: H9YXW9
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9544:TNFAIP1
gene id: 9544:TNFAIP1
uniprot id: A0A8J8XLT6
uniprot id: H9FZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9544:SYNGR2
gene id: 9544:SYNGR2
uniprot id: F7EHS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9544:PRPF38A
gene id: 9544:PRPF38A
uniprot id: H9EQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9544:PARP11
gene id: 9544:PARP11
uniprot id: A0A5F8AEF1
uniprot id: A0A8J8YDX2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:VIPAS39
gene id: 9544:VIPAS39
uniprot id: A0A8J8XF23
uniprot id: G7MYW8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9544:SLC27A1
gene id: 9544:SLC27A1
uniprot id: A0A8J8XYT6
uniprot id: G7NMS0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:IFI35
gene id: 9544:IFI35
uniprot id: I0FRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:PSMB6
gene id: 9544:PSMB6
uniprot id: G7NI33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:GPHB5
gene id: 9544:GPHB5
uniprot id: A0A8J8YSL7
uniprot id: F7GWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9544:SLC16A13
gene id: 9544:SLC16A13
uniprot id: F7H6H5
names: Subcellular Location Annotation
messages: Membrane

9544:DNPH1
gene id: 9544:DNPH1
uniprot id: F6RYK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9544:NOB1
gene id: 9544:NOB1
uniprot id: A0A8J8Y3K7
uniprot id: H9Z0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9544:HSF2
gene id: 9544:HSF2
uniprot id: F6PRI6
uniprot id: H9FTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:GUCA2B
gene id: 9544:GUCA2B
uniprot id: A0A8J8YIH5
uniprot id: F6Y5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9544:MRGPRD
gene id: 9544:MRGPRD
uniprot id: W8W3E5
names: Subcellular Location Annotation
messages: Cell membrane

9544:NDUFB7
gene id: 9544:NDUFB7
uniprot id: A0A8J8YL08
uniprot id: F7E420
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9544:CSTF3
gene id: 9544:CSTF3
uniprot id: A0A1D5QQW9
names: Subcellular Location Annotation
messages: Nucleus

9544:PLAC8
gene id: 9544:PLAC8
uniprot id: A0A8J8XJ76
uniprot id: F6U372
names: Similarity
messages: Belongs to the cornifelin family.

9544:VEZT
gene id: 9544:VEZT
uniprot id: A0A8J8XEM0
uniprot id: F7A020
uniprot id: H9FWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9544:TNKS
gene id: 9544:TNKS
uniprot id: A0A8J8XKK4
uniprot id: F6QQJ9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:LOC695847
gene id: 9544:LOC695847
uniprot id: F7GZC5
names: Subcellular Location Annotation
messages: Nucleus

9544:UTP15
gene id: 9544:UTP15
uniprot id: F7DXL1
names: Subcellular Location Annotation
messages: nucleolus

9544:TAS2R7
gene id: 9544:TAS2R7
uniprot id: G7N657
uniprot id: Q645T7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9544:EVL
gene id: 9544:EVL
uniprot id: H9FVJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9544:SGTA
gene id: 9544:SGTA
uniprot id: F7FGF5
names: Similarity
messages: Belongs to the SGT family.

9544:ADAMTS1
gene id: 9544:ADAMTS1
uniprot id: A0A8J8XNF4
uniprot id: G7MNA9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:LYN
gene id: 9544:LYN
uniprot id: A0A8J8YHP5
uniprot id: F7BV42
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:SYNGR1
gene id: 9544:SYNGR1
uniprot id: F6R375
uniprot id: I0FMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9544:EIF3M
gene id: 9544:EIF3M
uniprot id: H9EQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9544:SBF2
gene id: 9544:SBF2
uniprot id: A0A5K1V3F8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:ATP2B1
gene id: 9544:ATP2B1
uniprot id: F7E3S4
uniprot id: H9Z9D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: synaptic vesicle membrane

9544:CRYGN
gene id: 9544:CRYGN
uniprot id: A0A8J8YQT6
uniprot id: F7H5C8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:GPBP1
gene id: 9544:GPBP1
uniprot id: F7FZ98
uniprot id: F7H9N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9544:LUM
gene id: 9544:LUM
uniprot id: A0A8J8XLK1
uniprot id: F6PRP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9544:MFSD3
gene id: 9544:MFSD3
uniprot id: A0A5F7Z7R9
uniprot id: A0A5F8AFJ6
names: Subcellular Location Annotation
messages: Membrane

9544:RPS24
gene id: 9544:RPS24
uniprot id: A0A8J8YEU6
uniprot id: F7GV47
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9544:TVP23B
gene id: 9544:TVP23B
uniprot id: A0A1D5QSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9544:PRKACA
gene id: 9544:PRKACA
uniprot id: H9EQQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9544:AADAC
gene id: 9544:AADAC
uniprot id: F7G6L8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:CCDC65
gene id: 9544:CCDC65
uniprot id: F7DVF7
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9544:POMGNT1
gene id: 9544:POMGNT1
uniprot id: A0A1D5QKD7
uniprot id: F7GR52
uniprot id: G7MGQ7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9544:ITIH3
gene id: 9544:ITIH3
uniprot id: F7GAT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9544:SLC25A5
gene id: 9544:SLC25A5
uniprot id: I0FR46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:TSPAN5
gene id: 9544:TSPAN5
uniprot id: A0A1D5REZ6
uniprot id: A0A5F8AB78
uniprot id: A0A8J8Y5J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:BMP10
gene id: 9544:BMP10
uniprot id: A0A8J8YQK3
uniprot id: F6TKR2
names: Similarity
messages: Belongs to the TGF-beta family.

9544:XPC
gene id: 9544:XPC
uniprot id: A0A5F7ZQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9544:RGS7BP
gene id: 9544:RGS7BP
uniprot id: A0A8J8XGB0
uniprot id: G7MU59
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9544:C8H8orf37
gene id: 9544:C8H8orf37
uniprot id: H9FQI8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9544:ICAM2
gene id: 9544:ICAM2
uniprot id: A0A8J8Y0H8
uniprot id: F7FYU5
uniprot id: Q5NKU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9544:POLR2I
gene id: 9544:POLR2I
uniprot id: A0A8J8XPJ3
uniprot id: I0FFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9544:MMP28
gene id: 9544:MMP28
uniprot id: A0A1D5Q565
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:RAD52
gene id: 9544:RAD52
uniprot id: H9FXY9
names: Similarity
messages: Belongs to the RAD52 family.

9544:RER1
gene id: 9544:RER1
uniprot id: A0A8J8XY61
uniprot id: F7ENZ6
uniprot id: G7MGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9544:GTPBP1
gene id: 9544:GTPBP1
uniprot id: A0A1D5REG1
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

9544:BTG1
gene id: 9544:BTG1
uniprot id: F6Y7P5
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

9544:RNF7
gene id: 9544:RNF7
uniprot id: A0A5K1V2Z7
uniprot id: F7H413
names: Similarity
messages: Belongs to the RING-box family.

9544:MNS1
gene id: 9544:MNS1
uniprot id: F7D3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9544:RET
gene id: 9544:RET
uniprot id: F6S299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9544:MEIS3
gene id: 9544:MEIS3
uniprot id: H9FXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9544:SLC35B4
gene id: 9544:SLC35B4
uniprot id: F7HQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9544:SMIM15
gene id: 9544:SMIM15
uniprot id: F7END3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9544:CCNK
gene id: 9544:CCNK
uniprot id: F7DAF2
names: Similarity
messages: Belongs to the cyclin family.

9544:NUP62
gene id: 9544:NUP62
uniprot id: A0A8J8Y7N0
uniprot id: F6ZN69
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9544:IHH
gene id: 9544:IHH
uniprot id: F6RAT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: Secreted
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9544:OSTC
gene id: 9544:OSTC
uniprot id: H9FXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9544:MDH2
gene id: 9544:MDH2
uniprot id: A0A8J8XJD3
uniprot id: G7MNY8
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9544:BRMS1L
gene id: 9544:BRMS1L
uniprot id: F7B4M6
names: Subcellular Location Annotation
messages: Nucleus

9544:CRYBB2
gene id: 9544:CRYBB2
uniprot id: F7FCM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9544:EPHB4
gene id: 9544:EPHB4
uniprot id: F7E595
names: Subcellular Location Annotation
messages: Membrane

9544:FOS
gene id: 9544:FOS
uniprot id: A0A8J8XN26
uniprot id: A5A6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9544:DIPK2B
gene id: 9544:DIPK2B
uniprot id: A0A8J8XMB4
uniprot id: G7NT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9544:CASC3
gene id: 9544:CASC3
uniprot id: A0A1D5R604
uniprot id: F6XDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9544:MESD
gene id: 9544:MESD
uniprot id: A0A8J8Y6V5
uniprot id: G7MYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9544:GPR18
gene id: 9544:GPR18
uniprot id: F7FDS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9544:UBN2
gene id: 9544:UBN2
uniprot id: A0A5F7ZGG6
uniprot id: F7B3U8
names: Similarity
messages: Belongs to the ubinuclein family.

9544:PDIA2
gene id: 9544:PDIA2
uniprot id: I2CUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:NPLOC4
gene id: 9544:NPLOC4
uniprot id: H9FWY0
names: Similarity
messages: Belongs to the NPL4 family.

9544:DCTN6
gene id: 9544:DCTN6
uniprot id: F6S8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9544:DNAJC18
gene id: 9544:DNAJC18
uniprot id: A0A8J8XSZ0
uniprot id: G7MUW8
names: Subcellular Location Annotation
messages: Membrane

9544:WNT10B
gene id: 9544:WNT10B
uniprot id: G7N6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:EML3
gene id: 9544:EML3
uniprot id: H9FSH0
uniprot id: I0FKX6
names: Subcellular Location Annotation
messages: cytoskeleton

9544:PACSIN2
gene id: 9544:PACSIN2
uniprot id: A0A8J8YPA4
uniprot id: G7N443
uniprot id: H9FPE7
uniprot id: H9FPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9544:SYPL2
gene id: 9544:SYPL2
uniprot id: A0A1D5Q3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9544:MAPKAPK3
gene id: 9544:MAPKAPK3
uniprot id: A0A8J8XLX9
uniprot id: F7BFL2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:H2AFY
gene id: 9544:H2AFY
uniprot id: A0A5K1VFC3
uniprot id: A0A8J8XTA7
uniprot id: I0FJN0
uniprot id: I2CUE9
uniprot id: I2CUF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9544:METTL6
gene id: 9544:METTL6
uniprot id: A0A8J8XLT5
uniprot id: G7MJV8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9544:MMP11
gene id: 9544:MMP11
uniprot id: H9H3A5
names: Similarity
messages: Belongs to the peptidase M10A family.

9544:CXCR2
gene id: 9544:CXCR2
uniprot id: Q8HZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:FAM172A
gene id: 9544:FAM172A
uniprot id: A0A5F7ZUJ6
uniprot id: I0FGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

9544:SNRNP27
gene id: 9544:SNRNP27
uniprot id: F6S452
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9544:FBXO45
gene id: 9544:FBXO45
uniprot id: A0A5F7ZC38
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9544:GDA
gene id: 9544:GDA
uniprot id: F7CWS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9544:PAX6
gene id: 9544:PAX6
uniprot id: F7C9W0
uniprot id: H9FV32
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:SLC9A4
gene id: 9544:SLC9A4
uniprot id: F6XBB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9544:FLVCR2
gene id: 9544:FLVCR2
uniprot id: A0A1D5Q1F5
names: Subcellular Location Annotation
messages: Membrane

9544:UBE2E3
gene id: 9544:UBE2E3
uniprot id: A0A1D5QJN8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:DGAT1
gene id: 9544:DGAT1
uniprot id: A0A5F8ABT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9544:CDK5R1
gene id: 9544:CDK5R1
uniprot id: A0A8J8XGA9
uniprot id: F6Y8D3
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9544:NEXMIF
gene id: 9544:NEXMIF
uniprot id: A0A8J8YEH8
uniprot id: F7B9W8
names: Subcellular Location Annotation
messages: Nucleus

9544:CCDC149
gene id: 9544:CCDC149
uniprot id: F6SES1
uniprot id: I2CTJ2
names: Similarity
messages: Belongs to the CCDC149 family.

9544:KRT34
gene id: 9544:KRT34
uniprot id: A0A5K1VLD6
names: Similarity
messages: Belongs to the intermediate filament family.

9544:HDC
gene id: 9544:HDC
uniprot id: A0A8J8Y568
uniprot id: F7HFR2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:DENND6A
gene id: 9544:DENND6A
uniprot id: A0A1D5R1E5
uniprot id: F6XZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9544:RAP2B
gene id: 9544:RAP2B
uniprot id: A0A8J8YGZ1
uniprot id: F7AWM6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9544:LOC696463
gene id: 9544:LOC696463
uniprot id: F7FGT7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:USP27X
gene id: 9544:USP27X
uniprot id: H9EQI3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:KCNV1
gene id: 9544:KCNV1
uniprot id: F6YIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9544:CYGB
gene id: 9544:CYGB
uniprot id: H9FPJ4
names: Similarity
messages: Belongs to the globin family.

9544:EIF3E
gene id: 9544:EIF3E
uniprot id: F6Y9Q0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9544:PRDM14
gene id: 9544:PRDM14
uniprot id: A0A8J8XHQ0
uniprot id: F7ARZ8
names: Subcellular Location Annotation
messages: Nucleus

9544:PIGH
gene id: 9544:PIGH
uniprot id: A0A8J8XTX9
uniprot id: F6URF9
names: Similarity
messages: Belongs to the PIGH family.

9544:CHMP4B
gene id: 9544:CHMP4B
uniprot id: H9FPW6
names: Similarity
messages: Belongs to the SNF7 family.

9544:ZNF687
gene id: 9544:ZNF687
uniprot id: A0A8J8YPH2
uniprot id: F6Z211
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:CRPPA
gene id: 9544:CRPPA
uniprot id: A0A5F8ART5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9544:GJA10
gene id: 9544:GJA10
uniprot id: G7MPX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:STARD6
gene id: 9544:STARD6
uniprot id: F7GLT4
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9544:CPA5
gene id: 9544:CPA5
uniprot id: A0A1D5RCX2
uniprot id: A0A8J8XWF2
names: Similarity
messages: Belongs to the peptidase M14 family.

9544:RPL26L1
gene id: 9544:RPL26L1
uniprot id: A0A8J8YIQ8
uniprot id: F6V6Z8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9544:RARA
gene id: 9544:RARA
uniprot id: I0FG12
uniprot id: I0FG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:SKAP2
gene id: 9544:SKAP2
uniprot id: A0A1D5R563
names: Similarity
messages: Belongs to the SKAP family.

9544:GABRQ
gene id: 9544:GABRQ
uniprot id: A0A8J8YPZ8
uniprot id: F7F4H9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:PCYOX1L
gene id: 9544:PCYOX1L
uniprot id: F7F5G4
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9544:DUSP1
gene id: 9544:DUSP1
uniprot id: A0A8J8Y5G1
uniprot id: F7ES52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9544:DNMT3L
gene id: 9544:DNMT3L
uniprot id: A0A8J8XEH8
uniprot id: F7BC47
names: Subcellular Location Annotation
messages: Nucleus

9544:UGT2B33
gene id: 9544:UGT2B33
uniprot id: Q9GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.

9544:TMEM97
gene id: 9544:TMEM97
uniprot id: A0A8J8XM83
uniprot id: G7NGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9544:RO60
gene id: 9544:RO60
uniprot id: F7FMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9544:CLPTM1L
gene id: 9544:CLPTM1L
uniprot id: A0A5F7ZAX1
uniprot id: F7CT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9544:NEDD8
gene id: 9544:NEDD8
uniprot id: H9Z2S2
names: Similarity
messages: Belongs to the ubiquitin family.

9544:SLC35E1
gene id: 9544:SLC35E1
uniprot id: F7GVS0
names: Subcellular Location Annotation
messages: Membrane

9544:CRBN
gene id: 9544:CRBN
uniprot id: H9FVB2
uniprot id: Q3YAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Belongs to the yippee family.
messages: Nucleus

9544:IDNK
gene id: 9544:IDNK
uniprot id: A0A8J8Y0S0
uniprot id: F7AQ41
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9544:HDGFL2
gene id: 9544:HDGFL2
uniprot id: I0FH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9544:EXOC3
gene id: 9544:EXOC3
uniprot id: A0A8J8YD84
uniprot id: G7MU42
names: Similarity
messages: Belongs to the SEC6 family.

9544:P3H2
gene id: 9544:P3H2
uniprot id: I0FT21
names: Similarity
messages: Belongs to the leprecan family.

9544:ONECUT1
gene id: 9544:ONECUT1
uniprot id: F7BS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:RPS4X
gene id: 9544:RPS4X
uniprot id: F7FG14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:PLPPR4
gene id: 9544:PLPPR4
uniprot id: F7HG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:AGO1
gene id: 9544:AGO1
uniprot id: H9FSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9544:BPNT1
gene id: 9544:BPNT1
uniprot id: H9FNA3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9544:CIAO1
gene id: 9544:CIAO1
uniprot id: A0A8J8XKG5
uniprot id: F6SGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9544:GAD1
gene id: 9544:GAD1
uniprot id: A0A8J8YFI2
uniprot id: G7N8A4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:DBT
gene id: 9544:DBT
uniprot id: A0A1D5R7T4
uniprot id: A0A8J8YSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9544:POLD2
gene id: 9544:POLD2
uniprot id: A0A8J8XIF4
uniprot id: F6PLY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9544:BCAP29
gene id: 9544:BCAP29
uniprot id: F7HKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9544:CLVS1
gene id: 9544:CLVS1
uniprot id: A0A8J8XGR7
uniprot id: F7DKJ0
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9544:ACTG1
gene id: 9544:ACTG1
uniprot id: F6TII3
names: Similarity
messages: Belongs to the actin family.

9544:KCTD17
gene id: 9544:KCTD17
uniprot id: F7HM04
uniprot id: I2CU87
names: Subcellular Location Annotation
messages: Cell membrane

9544:PURG
gene id: 9544:PURG
uniprot id: I0FR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9544:PMP22
gene id: 9544:PMP22
uniprot id: A0A8J8Y435
uniprot id: F6W2G0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9544:COX11
gene id: 9544:COX11
uniprot id: A0A8J8XE01
uniprot id: G7NHP1
uniprot id: Q4G3Z4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9544:RPS16
gene id: 9544:RPS16
uniprot id: F6T928
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9544:ME3
gene id: 9544:ME3
uniprot id: H9FP20
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9544:ADGRE2
gene id: 9544:ADGRE2
uniprot id: Q2Q426
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Binding to chondroitin sulfate is mediated by the fourth EGF domain.
messages: Cell membrane
messages: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55 (By similarity).
messages: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
messages: ruffle membrane

9544:GLS
gene id: 9544:GLS
uniprot id: H9ESE7
uniprot id: I2CUE6
names: Similarity
messages: Belongs to the glutaminase family.

9544:HSBP1L1
gene id: 9544:HSBP1L1
uniprot id: H9FMX9
names: Similarity
messages: Belongs to the HSBP1 family.

9544:PIH1D1
gene id: 9544:PIH1D1
uniprot id: A0A8J8XG84
uniprot id: F7H5R9
names: Similarity
messages: Belongs to the PIH1 family.

9544:MAP7D1
gene id: 9544:MAP7D1
uniprot id: A0A5F7Z8M9
uniprot id: H9ZB33
names: Similarity
messages: Belongs to the MAP7 family.

9544:GNAQ
gene id: 9544:GNAQ
uniprot id: H9FT55
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9544:CELF3
gene id: 9544:CELF3
uniprot id: F7CBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9544:EPB41L5
gene id: 9544:EPB41L5
uniprot id: A0A1D5QMD7
uniprot id: F7D3R4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

9544:TRMT112
gene id: 9544:TRMT112
uniprot id: F7CV76
names: Similarity
messages: Belongs to the TRM112 family.

9544:AK3
gene id: 9544:AK3
uniprot id: H9FV35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9544:ATP5MC3
gene id: 9544:ATP5MC3
uniprot id: A0A8J8XHG3
uniprot id: F6ZG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:SLC7A11
gene id: 9544:SLC7A11
uniprot id: A0A5F8AAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9544:PNLDC1
gene id: 9544:PNLDC1
uniprot id: F6X2Q9
names: Similarity
messages: Belongs to the CAF1 family.

9544:KCNA4
gene id: 9544:KCNA4
uniprot id: A0A8J8XU25
uniprot id: F6QDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9544:DEFB114
gene id: 9544:DEFB114
uniprot id: A0A8J8XJB5
uniprot id: F6Z9U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:SLC6A17
gene id: 9544:SLC6A17
uniprot id: A0A8J8XCD5
uniprot id: G7MIF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:FABP7
gene id: 9544:FABP7
uniprot id: F6TB55
uniprot id: G7MQL6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:TLL2
gene id: 9544:TLL2
uniprot id: F7CEL9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ZDHHC22
gene id: 9544:ZDHHC22
uniprot id: A0A8J8YN37
uniprot id: G7MYW0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:FAM189B
gene id: 9544:FAM189B
uniprot id: A0A1D5Q584
uniprot id: G7MDW8
names: Similarity
messages: Belongs to the ENTREP family.

9544:INSRR
gene id: 9544:INSRR
uniprot id: A0A5F7ZFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:PRKAG1
gene id: 9544:PRKAG1
uniprot id: H9EQE8
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9544:UCP2
gene id: 9544:UCP2
uniprot id: F7H9F2
uniprot id: Q9N1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:PES1
gene id: 9544:PES1
uniprot id: F6WSE9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9544:PSMA7
gene id: 9544:PSMA7
uniprot id: H9FXA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:DZIP3
gene id: 9544:DZIP3
uniprot id: F6REG1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LIFR
gene id: 9544:LIFR
uniprot id: F7E0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9544:STON2
gene id: 9544:STON2
uniprot id: A0A5F8ACL5
uniprot id: F7H5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9544:CASP14
gene id: 9544:CASP14
uniprot id: F7GZH3
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:FLI1
gene id: 9544:FLI1
uniprot id: H9Z2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:DIMT1
gene id: 9544:DIMT1
uniprot id: A0A5K1VAG0
uniprot id: A0A8J8YSQ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9544:ERG
gene id: 9544:ERG
uniprot id: A0A1D5RFW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:LOC704096
gene id: 9544:LOC704096
uniprot id: F7CZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ALDH8A1
gene id: 9544:ALDH8A1
uniprot id: F7GPI8
uniprot id: F7GPJ0
uniprot id: G7MQB3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:PENK
gene id: 9544:PENK
uniprot id: A0A8J8Y287
uniprot id: G7MZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9544:C7H15orf40
gene id: 9544:C7H15orf40
uniprot id: A0A5K1UZ12
names: Similarity
messages: Belongs to the UPF0235 family.

9544:PALM2
gene id: 9544:PALM2
uniprot id: H9FPJ0
names: Similarity
messages: Belongs to the paralemmin family.

9544:RPF2
gene id: 9544:RPF2
uniprot id: A0A1D5QBG9
uniprot id: A0A8J8YP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9544:TM6SF1
gene id: 9544:TM6SF1
uniprot id: F7H8Q4
names: Subcellular Location Annotation
messages: Membrane

9544:METAP2
gene id: 9544:METAP2
uniprot id: H9Z4P2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9544:GRAMD1A
gene id: 9544:GRAMD1A
uniprot id: A0A5K1VTX9
uniprot id: A0A8J8Y129
uniprot id: G7NM35
uniprot id: H9FXQ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:OXCT1
gene id: 9544:OXCT1
uniprot id: A0A1D5QBH8
uniprot id: F7GQS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9544:TGFB2
gene id: 9544:TGFB2
uniprot id: A0A8J8XS43
uniprot id: F6ZJW6
uniprot id: F6ZJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9544:ADRM1
gene id: 9544:ADRM1
uniprot id: A0A8J8Y651
uniprot id: F7FSU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9544:COPS3
gene id: 9544:COPS3
uniprot id: A0A8J8XSK3
uniprot id: G7NJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9544:COQ8A
gene id: 9544:COQ8A
uniprot id: A0A8J8Y436
uniprot id: F7F8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9544:GANC
gene id: 9544:GANC
uniprot id: A0A8J8YQF3
uniprot id: H9EVN5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9544:RSL24D1
gene id: 9544:RSL24D1
uniprot id: F6PJJ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9544:ASIC2
gene id: 9544:ASIC2
uniprot id: H9F1E8
uniprot id: H9F9G2
names: Subcellular Location Annotation
messages: Membrane

9544:ST3GAL1
gene id: 9544:ST3GAL1
uniprot id: A0A1D5RE99
uniprot id: A0A8J8XDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:HTR1E
gene id: 9544:HTR1E
uniprot id: A0A8J8XJN8
uniprot id: F6XHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC698937
gene id: 9544:LOC698937
uniprot id: A0A1D5Q2L7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:ATP5F1D
gene id: 9544:ATP5F1D
uniprot id: F7ERL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9544:STAG2
gene id: 9544:STAG2
uniprot id: H9EMR3
uniprot id: I0FH65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9544:SUV39H2
gene id: 9544:SUV39H2
uniprot id: F7GYV0
uniprot id: F7GYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9544:PCMT1
gene id: 9544:PCMT1
uniprot id: F7GFV2
uniprot id: F7GFV8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9544:NAT9
gene id: 9544:NAT9
uniprot id: G7NGM6
uniprot id: H9FSS4
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9544:HDHD2
gene id: 9544:HDHD2
uniprot id: H9EV26
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:SEMA3F
gene id: 9544:SEMA3F
uniprot id: A0A8J8XCQ7
uniprot id: F7HC49
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TAF1D
gene id: 9544:TAF1D
uniprot id: F6PTS1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9544:KEG06 p05
gene id: 9544:KEG06_p05
uniprot id: I3W8K6
uniprot id: Q6IYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9544:DGAT2L6
gene id: 9544:DGAT2L6
uniprot id: F6SMA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:POLG2
gene id: 9544:POLG2
uniprot id: A0A5K1UDP8
names: Subcellular Location Annotation
messages: Mitochondrion

9544:OAT
gene id: 9544:OAT
uniprot id: A0A5F7ZD93
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:ASPHD2
gene id: 9544:ASPHD2
uniprot id: H9FXI1
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9544:PIGN
gene id: 9544:PIGN
uniprot id: A0A5F7ZMD8
uniprot id: A0A5F8A9N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CENPN
gene id: 9544:CENPN
uniprot id: A0A8J8XXG2
uniprot id: G7NR50
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9544:SLC6A11
gene id: 9544:SLC6A11
uniprot id: F6WVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:IL12A
gene id: 9544:IL12A
uniprot id: P48091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Secreted

9544:ETS2
gene id: 9544:ETS2
uniprot id: A0A8J8XIC2
uniprot id: G7MMS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9544:KAT5
gene id: 9544:KAT5
uniprot id: F7FU99
uniprot id: G7NC89
uniprot id: I2CWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9544:MOB1A
gene id: 9544:MOB1A
uniprot id: H9FWM3
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:TAFA4
gene id: 9544:TAFA4
uniprot id: A0A5F8ARS4
names: Similarity
messages: Belongs to the TAFA family.

9544:ZNF706
gene id: 9544:ZNF706
uniprot id: A0A8J8XW13
uniprot id: F7E1G3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:MRGPRX4
gene id: 9544:MRGPRX4
uniprot id: Q1L4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9544:IREB2
gene id: 9544:IREB2
uniprot id: A0A8J8YDE9
uniprot id: G7MYF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9544:SCGB1A1
gene id: 9544:SCGB1A1
uniprot id: F6S2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9544:OTX1
gene id: 9544:OTX1
uniprot id: A0A5F7ZLS2
names: Subcellular Location Annotation
messages: Nucleus

9544:INTS13
gene id: 9544:INTS13
uniprot id: H9FX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9544:VPS16
gene id: 9544:VPS16
uniprot id: A0A8J8XQN3
uniprot id: G7N2T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9544:TMEM242
gene id: 9544:TMEM242
uniprot id: A0A8J8XEN4
uniprot id: F7HL96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9544:DHRS7B
gene id: 9544:DHRS7B
uniprot id: A0A5K1UPY0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:SIX5
gene id: 9544:SIX5
uniprot id: F7GEZ3
names: Subcellular Location Annotation
messages: Nucleus

9544:EFS
gene id: 9544:EFS
uniprot id: H9FNL6
names: Similarity
messages: Belongs to the CAS family.

9544:LOC710568
gene id: 9544:LOC710568
uniprot id: A0A5F7Z8I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:UQCRH
gene id: 9544:UQCRH
uniprot id: A0A5K1UEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9544:ATP11C
gene id: 9544:ATP11C
uniprot id: F7EG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:SSTR4
gene id: 9544:SSTR4
uniprot id: F7C9S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:RBM17
gene id: 9544:RBM17
uniprot id: A0A8J8YSQ0
uniprot id: F6UDK4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9544:SLC30A4
gene id: 9544:SLC30A4
uniprot id: A0A8J8YDZ0
uniprot id: F7C602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:GAB3
gene id: 9544:GAB3
uniprot id: F6WAT4
names: Similarity
messages: Belongs to the GAB family.

9544:FAM120B
gene id: 9544:FAM120B
uniprot id: A0A1D5QFK4
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9544:MT1E
gene id: 9544:MT1E
uniprot id: A0A8J8XCC6
uniprot id: F7ECS1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:GDPD2
gene id: 9544:GDPD2
uniprot id: A0A5K1TYC9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9544:GSTM2
gene id: 9544:GSTM2
uniprot id: F7HIX7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9544:HOXA7
gene id: 9544:HOXA7
uniprot id: F6YGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:CDH5
gene id: 9544:CDH5
uniprot id: F6RFA8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9544:FCHO2
gene id: 9544:FCHO2
uniprot id: A0A5K1V654
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9544:KDELR1
gene id: 9544:KDELR1
uniprot id: F7H3E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:TMEM39A
gene id: 9544:TMEM39A
uniprot id: F7H043
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9544:MTERF4
gene id: 9544:MTERF4
uniprot id: A0A5F7ZSY2
names: Similarity
messages: Belongs to the mTERF family.

9544:CNIH3
gene id: 9544:CNIH3
uniprot id: F6RG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:TMEM106A
gene id: 9544:TMEM106A
uniprot id: A0A8J8XEQ5
uniprot id: F7CWZ4
uniprot id: G7NIU8
names: Similarity
messages: Belongs to the TMEM106 family.

9544:SLC10A5
gene id: 9544:SLC10A5
uniprot id: A0A1D5Q7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:RTN2
gene id: 9544:RTN2
uniprot id: H9EWR3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PPP2R5B
gene id: 9544:PPP2R5B
uniprot id: A0A8J8XAV9
uniprot id: G7NCH2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:ST8SIA1
gene id: 9544:ST8SIA1
uniprot id: A0A8J8XLB9
uniprot id: F6Z009
uniprot id: G7N6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:STEAP1
gene id: 9544:STEAP1
uniprot id: F6PLK4
names: Subcellular Location Annotation
messages: Membrane

9544:KPNA4
gene id: 9544:KPNA4
uniprot id: F7EGK1
uniprot id: H9EQP0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9544:NKX2-8
gene id: 9544:NKX2-8
uniprot id: G7MXM3
names: Subcellular Location Annotation
messages: Nucleus

9544:CDKN1A
gene id: 9544:CDKN1A
uniprot id: A0A8J8XZT2
uniprot id: F7EEK4
names: Similarity
messages: Belongs to the CDI family.

9544:ZSCAN23
gene id: 9544:ZSCAN23
uniprot id: A0A8J8Y1Y8
uniprot id: F7EAK6
names: Subcellular Location Annotation
messages: Nucleus

9544:HSPA1A
gene id: 9544:HSPA1A
uniprot id: A0A5F8A2S3
uniprot id: G7MRK7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:ZEB2
gene id: 9544:ZEB2
uniprot id: F7C2Y1
uniprot id: H9G2I9
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9544:RPL29
gene id: 9544:RPL29
uniprot id: A0A8J8YHL0
uniprot id: F6QGB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9544:GDF1
gene id: 9544:GDF1
uniprot id: F6ZBU9
names: Similarity
messages: Belongs to the TGF-beta family.

9544:WIF1
gene id: 9544:WIF1
uniprot id: A0A8J8Y2M9
uniprot id: H9FPD0
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TMEM173
gene id: 9544:TMEM173
uniprot id: H9YZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9544:ATP2A1
gene id: 9544:ATP2A1
uniprot id: G7NQG5
uniprot id: I2CX33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:EDIL3
gene id: 9544:EDIL3
uniprot id: A0A1D5RFH0
uniprot id: A0A8J8XRE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SPTAN1
gene id: 9544:SPTAN1
uniprot id: A0A5K1TXE9
uniprot id: H9EN73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9544:CCL20
gene id: 9544:CCL20
uniprot id: Q8HYP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:SMARCAD1
gene id: 9544:SMARCAD1
uniprot id: H9FXC5
names: Subcellular Location Annotation
messages: Chromosome

9544:CYP4V2
gene id: 9544:CYP4V2
uniprot id: H9EWH9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:MYD88
gene id: 9544:MYD88
uniprot id: B3Y683
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9544:BANF1
gene id: 9544:BANF1
uniprot id: F6T830
names: Subcellular Location Annotation
messages: Nucleus

9544:CADM1
gene id: 9544:CADM1
uniprot id: A0A1D5RGN2
names: Similarity
messages: Belongs to the nectin family.

9544:HCRT
gene id: 9544:HCRT
uniprot id: F7GWM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9544:ALDH1L2
gene id: 9544:ALDH1L2
uniprot id: F6W9P8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9544:NLRP5
gene id: 9544:NLRP5
uniprot id: B0FNB0
names: Similarity
messages: Belongs to the NLRP family.

9544:ATF7IP
gene id: 9544:ATF7IP
uniprot id: H9FX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9544:ADAM9
gene id: 9544:ADAM9
uniprot id: F6SGK2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CDK5RAP1
gene id: 9544:CDK5RAP1
uniprot id: F7B9L0
uniprot id: H9FVP6
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9544:GALNT11
gene id: 9544:GALNT11
uniprot id: A0A5K1TVC0
uniprot id: F6V8F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:ZFHX4
gene id: 9544:ZFHX4
uniprot id: F6RGC8
names: Subcellular Location Annotation
messages: Nucleus

9544:GPRIN2
gene id: 9544:GPRIN2
uniprot id: F6YNR6
names: Function
messages: May be involved in neurite outgrowth.

9544:TRIM67
gene id: 9544:TRIM67
uniprot id: F6S2G3
names: Subcellular Location Annotation
messages: cytoskeleton

9544:ARL2
gene id: 9544:ARL2
uniprot id: H9ESA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9544:DNM2
gene id: 9544:DNM2
uniprot id: F7FL98
uniprot id: F7FLA4
uniprot id: I2CY05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9544:KIF13A
gene id: 9544:KIF13A
uniprot id: F7G1S8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:PPTC7
gene id: 9544:PPTC7
uniprot id: A0A5F8ASV2
names: Similarity
messages: Belongs to the PP2C family.

9544:UBE2L3
gene id: 9544:UBE2L3
uniprot id: H9FZA6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:ITGB4
gene id: 9544:ITGB4
uniprot id: F7DF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9544:SIN3B
gene id: 9544:SIN3B
uniprot id: F6YZ56
uniprot id: F7A9F4
names: Subcellular Location Annotation
messages: Nucleus

9544:MT1X
gene id: 9544:MT1X
uniprot id: A0A8J8XBT2
uniprot id: F7GC79
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:RPS7
gene id: 9544:RPS7
uniprot id: F7H2G1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9544:HIKESHI
gene id: 9544:HIKESHI
uniprot id: A0A8J8XHK1
uniprot id: F7F804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9544:SAMD8
gene id: 9544:SAMD8
uniprot id: H9EP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9544:TMCO1
gene id: 9544:TMCO1
uniprot id: A0A8J8Y534
uniprot id: H9YVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9544:DDX58
gene id: 9544:DDX58
uniprot id: Q0PXR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9544:RXFP4
gene id: 9544:RXFP4
uniprot id: A0A8J8YAA0
uniprot id: F6U984
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:SRSF1
gene id: 9544:SRSF1
uniprot id: H9ZCA8
names: Similarity
messages: Belongs to the splicing factor SR family.

9544:ATF7IP2
gene id: 9544:ATF7IP2
uniprot id: F6WW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9544:PDIA3
gene id: 9544:PDIA3
uniprot id: F6W4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:ADD1
gene id: 9544:ADD1
uniprot id: A0A1D5R5T2
uniprot id: A0A8J8YM99
uniprot id: F7HMM7
uniprot id: G7MFT4
uniprot id: H9FPQ0
uniprot id: I2CY41
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9544:TXNL4A
gene id: 9544:TXNL4A
uniprot id: F7GUX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9544:MEOX2
gene id: 9544:MEOX2
uniprot id: A0A8J8XZL0
uniprot id: F7C188
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC17A4
gene id: 9544:SLC17A4
uniprot id: G7MQV6
names: Subcellular Location Annotation
messages: Membrane

9544:SLC26A2
gene id: 9544:SLC26A2
uniprot id: A0A5F7ZUI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9544:ATRX
gene id: 9544:ATRX
uniprot id: F6UJ05
uniprot id: F6ZEI1
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9544:SUOX
gene id: 9544:SUOX
uniprot id: A0A5F8AS39
names: Function
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.

9544:HADH
gene id: 9544:HADH
uniprot id: F7DIX8
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9544:DXO
gene id: 9544:DXO
uniprot id: I2CVZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9544:NUP85
gene id: 9544:NUP85
uniprot id: H9FZZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9544:ARSE
gene id: 9544:ARSE
uniprot id: A0A5F7ZLY5
uniprot id: A0A8J8XVK0
uniprot id: G7NS12
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:SLC9A3R1
gene id: 9544:SLC9A3R1
uniprot id: H9EVX8
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

9544:LOC715778
gene id: 9544:LOC715778
uniprot id: A0A1D5RBC6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9544:NT5C3A
gene id: 9544:NT5C3A
uniprot id: A0A5F8A2T2
uniprot id: A0A5F8A4W8
uniprot id: A0A8J8XQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9544:ZSCAN25
gene id: 9544:ZSCAN25
uniprot id: F7GIA5
names: Subcellular Location Annotation
messages: Nucleus

9544:CLCN3
gene id: 9544:CLCN3
uniprot id: A0A1D5Q4G1
uniprot id: H9EPI1
uniprot id: H9EPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:MTMR9
gene id: 9544:MTMR9
uniprot id: F7GG61
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:CTF1
gene id: 9544:CTF1
uniprot id: A0A1D5Q3R3
uniprot id: A0A5F8ATV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9544:PRDM12
gene id: 9544:PRDM12
uniprot id: A0A5F7ZNG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9544:GML
gene id: 9544:GML
uniprot id: A0A8J8YJZ5
uniprot id: G7N077
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane