9541:PKD2
gene id: 9541:PKD2
uniprot id: A0A2K5VH75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:CXXC5
gene id: 9541:CXXC5
uniprot id: I7GIK3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SLC6A14
gene id: 9541:SLC6A14
uniprot id: A0A2K5TPZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9541:PRKAB1
gene id: 9541:PRKAB1
uniprot id: A0A8J8XCL8
uniprot id: G7PIT4
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9541:IMP4
gene id: 9541:IMP4
uniprot id: A0A7N9CN51
names: Subcellular Location Annotation
messages: nucleolus

9541:EIF2S2
gene id: 9541:EIF2S2
uniprot id: A0A2K5W5I2
uniprot id: Q4R5G5
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9541:GPHB5
gene id: 9541:GPHB5
uniprot id: A0A7N9IDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9541:MEGF10
gene id: 9541:MEGF10
uniprot id: A0A2K5VD65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TBC1D23
gene id: 9541:TBC1D23
uniprot id: A0A2K5UTW2
uniprot id: A0A2K5UTY6
uniprot id: A0A2K5UU06
uniprot id: A0A8J8XGF9
uniprot id: G7NZ86
names: Subcellular Location Annotation
messages: trans-Golgi network

9541:LCMT1
gene id: 9541:LCMT1
uniprot id: A0A7N9CBY8
uniprot id: A0A7N9CIE3
uniprot id: A0A7N9IAE8
uniprot id: I7GA68
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9541:GABRA6
gene id: 9541:GABRA6
uniprot id: G7P6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:GALK1
gene id: 9541:GALK1
uniprot id: A0A2K5UGN0
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9541:PKN2
gene id: 9541:PKN2
uniprot id: A0A2K5UQ73
uniprot id: A0A8J8YH34
uniprot id: G7NTM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9541:SEMA5A
gene id: 9541:SEMA5A
uniprot id: A0A2K5WPX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RPL18
gene id: 9541:RPL18
uniprot id: Q4R5H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9541:CHM
gene id: 9541:CHM
uniprot id: A0A2K5VYT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9541:XPNPEP1
gene id: 9541:XPNPEP1
uniprot id: A0A2K5UNK8
names: Similarity
messages: Belongs to the peptidase M24B family.

9541:BCO2
gene id: 9541:BCO2
uniprot id: Q8HXG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules.
messages: Mitochondrion

9541:LOC102122149
gene id: 9541:LOC102122149
uniprot id: A0A8J8Y9Z4
uniprot id: G7P524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9541:PSMD2
gene id: 9541:PSMD2
uniprot id: A0A2K5WKI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9541:MEIS1
gene id: 9541:MEIS1
uniprot id: A0A2K5U2K1
uniprot id: A0A2K5U2L5
uniprot id: A0A2K5U2L9
uniprot id: A0A2K5U2N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9541:ATP1B1
gene id: 9541:ATP1B1
uniprot id: Q4R4V5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Glutathionylated (By similarity). N-glycosylated (By similarity).
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
messages: sarcolemma

9541:CNTFR
gene id: 9541:CNTFR
uniprot id: A0A2K5WIH9
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9541:GDPD2
gene id: 9541:GDPD2
uniprot id: A0A2K5WIT9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:SLC30A2
gene id: 9541:SLC30A2
uniprot id: A0A2K5W895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9541:CFL2
gene id: 9541:CFL2
uniprot id: A0A8J8YPP2
uniprot id: G7PA25
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9541:SNCG
gene id: 9541:SNCG
uniprot id: G7PEV7
uniprot id: Q2PFW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.
messages: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity).
messages: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
messages: centrosome
messages: perinuclear region
messages: spindle

9541:VPS4B
gene id: 9541:VPS4B
uniprot id: A0A2K5VZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:KCNK13
gene id: 9541:KCNK13
uniprot id: A0A8J8XPH6
uniprot id: G7PB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:PDE1C
gene id: 9541:PDE1C
uniprot id: A0A2K5WRJ8
uniprot id: A0A2K5WRL9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:SPATA18
gene id: 9541:SPATA18
uniprot id: Q95K37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).
messages: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
messages: Mitochondrion outer membrane

9541:CHRM1
gene id: 9541:CHRM1
uniprot id: A0A2K5ULM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9541:PHACTR3
gene id: 9541:PHACTR3
uniprot id: A0A2K5WI24
uniprot id: I7GKZ0
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9541:YWHAG
gene id: 9541:YWHAG
uniprot id: A0A2K5WMN9
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:SGF29
gene id: 9541:SGF29
uniprot id: A0A2K5WKH8
uniprot id: Q4R7C7
names: Subcellular Location Annotation
messages: Nucleus

9541:FBN3
gene id: 9541:FBN3
uniprot id: A0A2K5TS66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:DNM1L
gene id: 9541:DNM1L
uniprot id: A0A2K5UCX1
uniprot id: A0A2K5UCX6
uniprot id: A0A2K5UD34
uniprot id: Q4R5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

9541:CEP44
gene id: 9541:CEP44
uniprot id: A0A2K5W9Y3
uniprot id: Q4R7I0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
messages: Interacts with CROCC. Interacts with POC1B; the interaction is direct and recruits POC1B to centriolar microtubules. Binds to centriolar microtubules.
messages: Midbody
messages: centriole
messages: centrosome
messages: spindle pole

9541:ASPH
gene id: 9541:ASPH
uniprot id: A0A2K5UVU0
uniprot id: A0A2K5UVW6
uniprot id: A0A2K5UVW8
uniprot id: A0A2K5UW09
uniprot id: A0A2K5UW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9541:GPN1
gene id: 9541:GPN1
uniprot id: I7GH38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9541:APOC1
gene id: 9541:APOC1
uniprot id: P18657
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.
messages: Belongs to the apolipoprotein C1 family.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9541:CASC3
gene id: 9541:CASC3
uniprot id: A0A2K5WWK0
uniprot id: A0A2K5WWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9541:AGTR1
gene id: 9541:AGTR1
uniprot id: G7NZZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9541:ATP5F1E
gene id: 9541:ATP5F1E
uniprot id: A0A2K5UDE9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9541:MUTYH
gene id: 9541:MUTYH
uniprot id: A0A2K5UK75
uniprot id: A0A2K5UK92
uniprot id: Q4R343
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

9541:VWC2L
gene id: 9541:VWC2L
uniprot id: A0A2K5UC09
uniprot id: A0A8J8YL83
uniprot id: G7PLD0
names: Subcellular Location Annotation
messages: Synapse

9541:VEGFA
gene id: 9541:VEGFA
uniprot id: A0A7N9CDP5
uniprot id: A0A7N9IDA9
uniprot id: Q95NE5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9541:TMTC1
gene id: 9541:TMTC1
uniprot id: A0A2K5V7C9
uniprot id: A0A2K5V7E7
uniprot id: A0A7N9IGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:ST6GALNAC6
gene id: 9541:ST6GALNAC6
uniprot id: G8F557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:ZKSCAN8
gene id: 9541:ZKSCAN8
uniprot id: A0A8J8XTZ8
uniprot id: G7P3S3
names: Subcellular Location Annotation
messages: Nucleus

9541:LIPF
gene id: 9541:LIPF
uniprot id: A0A2K5VBR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:LOC102129682
gene id: 9541:LOC102129682
uniprot id: Q4R4K6
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
messages: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
messages: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.

9541:DYNC2H1
gene id: 9541:DYNC2H1
uniprot id: A0A2K5TLY8
uniprot id: A0A2K5TLZ0
names: Similarity
messages: Belongs to the dynein heavy chain family.

9541:ZNF711
gene id: 9541:ZNF711
uniprot id: A0A2K5W5G0
uniprot id: A0A8J8YJG0
uniprot id: G7Q360
names: Subcellular Location Annotation
messages: Nucleus

9541:OLA1
gene id: 9541:OLA1
uniprot id: A0A2K5VKG4
uniprot id: I7GJA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9541:RBKS
gene id: 9541:RBKS
uniprot id: A0A8J8XKD9
uniprot id: G7PLX7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9541:FMO2
gene id: 9541:FMO2
uniprot id: A0A2K5VS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:AQP9
gene id: 9541:AQP9
uniprot id: A0A8J8Y8Y4
uniprot id: G7PBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:ESYT1
gene id: 9541:ESYT1
uniprot id: A0A2K5WF44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SUSD4
gene id: 9541:SUSD4
uniprot id: A0A2K5VIA2
uniprot id: A0A2K5VIB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GRK5
gene id: 9541:GRK5
uniprot id: A0A2K5X7B6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:NKD2
gene id: 9541:NKD2
uniprot id: A0A2K5WT32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9541:SLC4A10
gene id: 9541:SLC4A10
uniprot id: A0A2K5WSF0
uniprot id: A0A2K5WSS1
uniprot id: A0A2K5WSW5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:RDX
gene id: 9541:RDX
uniprot id: I7G8X5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:NRM
gene id: 9541:NRM
uniprot id: A0A2K5X7A8
uniprot id: A0A7N9IHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9541:GPR83
gene id: 9541:GPR83
uniprot id: A0A7N9CN28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:PIGV
gene id: 9541:PIGV
uniprot id: A0A2K5WCU5
uniprot id: G8F2H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9541:MON2
gene id: 9541:MON2
uniprot id: A0A2K5X5N9
uniprot id: A0A2K5X5Q0
names: Similarity
messages: Belongs to the MON2 family.

9541:MON1B
gene id: 9541:MON1B
uniprot id: A0A2K5WX47
uniprot id: Q4R4E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MON1/SAND family.
messages: Interacts with CCNT2; down-regulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection. Found in a complex with RMC1, CCZ1 MON1A and MON1B.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9541:SLC13A2
gene id: 9541:SLC13A2
uniprot id: A0A2K5UTT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:SETD3
gene id: 9541:SETD3
uniprot id: A0A2K5WBQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9541:KCTD14
gene id: 9541:KCTD14
uniprot id: A0A8J8Y5I7
uniprot id: G7PNB4
names: Subcellular Location Annotation
messages: Cell membrane

9541:SCFD1
gene id: 9541:SCFD1
uniprot id: A0A2K5X101
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:SPESP1
gene id: 9541:SPESP1
uniprot id: G7P8X6
uniprot id: Q95LJ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis.
messages: Involved in fertilization ability of sperm.
messages: acrosome

9541:FAM120B
gene id: 9541:FAM120B
uniprot id: A0A2K5TS44
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9541:ELAPOR2
gene id: 9541:ELAPOR2
uniprot id: A0A2K5V0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9541:KCNK9
gene id: 9541:KCNK9
uniprot id: A0A7N9DCV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9541:HOXB2
gene id: 9541:HOXB2
uniprot id: A0A2K5U427
names: Subcellular Location Annotation
messages: Nucleus

9541:BCL2A1
gene id: 9541:BCL2A1
uniprot id: A0A2K5TMD8
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:AHDC1
gene id: 9541:AHDC1
uniprot id: A0A2K5UC45
names: Subcellular Location Annotation
messages: Nucleus

9541:PGK1
gene id: 9541:PGK1
uniprot id: G7Q337
uniprot id: Q60HD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
messages: Cytoplasm
messages: Monomer.

9541:NTN4
gene id: 9541:NTN4
uniprot id: A0A2K5TJQ8
uniprot id: A0A2K5TJR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SCMH1
gene id: 9541:SCMH1
uniprot id: A0A2K5W3Q4
uniprot id: A0A2K5W3S2
uniprot id: A0A2K5W3U6
uniprot id: A0A2K5W3U7
uniprot id: A0A8J8YP52
uniprot id: Q4R8H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9541:GCNT4
gene id: 9541:GCNT4
uniprot id: A0A2K5UCK1
uniprot id: G7P7R4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:NUP210
gene id: 9541:NUP210
uniprot id: A0A2K5VMY5
names: Similarity
messages: Belongs to the NUP210 family.

9541:DOCK8
gene id: 9541:DOCK8
uniprot id: A0A2K5UG46
uniprot id: A0A2K5UG61
uniprot id: A0A2K5UG74
names: Similarity
messages: Belongs to the DOCK family.

9541:ECE1
gene id: 9541:ECE1
uniprot id: A0A2K5VFW0
names: Function
messages: Converts big endothelin-1 to endothelin-1.

9541:LRP2
gene id: 9541:LRP2
uniprot id: A0A2K5VUP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:INHBE
gene id: 9541:INHBE
uniprot id: A0A8J8YNK9
uniprot id: G7PIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9541:ACTC1
gene id: 9541:ACTC1
uniprot id: A0A8J8YL82
uniprot id: G7PAP7
names: Similarity
messages: Belongs to the actin family.

9541:ZIC3
gene id: 9541:ZIC3
uniprot id: A0A2K5UKM4
uniprot id: G7Q1T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9541:CEP70
gene id: 9541:CEP70
uniprot id: A0A2K5TLP6
uniprot id: Q4R7V1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity).
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
messages: centrosome

9541:TMED4
gene id: 9541:TMED4
uniprot id: A0A2K5VAI8
uniprot id: A0A7N9D1Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:KMT2C
gene id: 9541:KMT2C
uniprot id: A0A2K5WSE5
uniprot id: A0A2K5WSR2
names: Subcellular Location Annotation
messages: Nucleus

9541:PROM1
gene id: 9541:PROM1
uniprot id: A0A2K5VIL3
uniprot id: A0A2K5VIM1
uniprot id: A0A2K5VIM5
uniprot id: A0A2K5VIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9541:MFSD6
gene id: 9541:MFSD6
uniprot id: A0A2K5UQX5
uniprot id: A0A7N9CQR8
uniprot id: G7PL19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9541:STEAP1
gene id: 9541:STEAP1
uniprot id: A0A2K5X1J3
names: Subcellular Location Annotation
messages: Membrane

9541:TFAP2A
gene id: 9541:TFAP2A
uniprot id: A0A2K5WXI6
uniprot id: A0A2K5WXM2
uniprot id: A0A2K5WXN6
uniprot id: A0A2K5WY41
uniprot id: A0A2K5WY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9541:GREM2
gene id: 9541:GREM2
uniprot id: A0A7N9CTP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ANKRD53
gene id: 9541:ANKRD53
uniprot id: Q4R739
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PSRC1; recruited by PSRC1 to the spindle during mitosis.
messages: Phosphorylated during mitosis.
messages: Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
messages: spindle
messages: spindle pole

9541:RPA3
gene id: 9541:RPA3
uniprot id: A0A2K5VY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9541:SERINC3
gene id: 9541:SERINC3
uniprot id: A0A2K5VS73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:YAF2
gene id: 9541:YAF2
uniprot id: A0A7N9CQ30
uniprot id: I7GL03
names: Subcellular Location Annotation
messages: Nucleus

9541:CCNG1
gene id: 9541:CCNG1
uniprot id: G7P6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9541:EFNA5
gene id: 9541:EFNA5
uniprot id: A0A2K5X7N8
uniprot id: A0A8J8XVD8
uniprot id: G7P813
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:TSEN2
gene id: 9541:TSEN2
uniprot id: A0A2K5WMX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9541:PPP1R42
gene id: 9541:PPP1R42
uniprot id: Q4R803
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules (By similarity).
messages: Phosphorylated; in the testis.
messages: Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.
messages: centrosome
messages: cytoskeleton

9541:USP35
gene id: 9541:USP35
uniprot id: A0A2K5U812
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:MRPS33
gene id: 9541:MRPS33
uniprot id: A0A8J8YM69
uniprot id: G7P1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9541:GPR17
gene id: 9541:GPR17
uniprot id: A0A2K5W356
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:ADCY10
gene id: 9541:ADCY10
uniprot id: A0A2K5V3Y6
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.

9541:ZDHHC23
gene id: 9541:ZDHHC23
uniprot id: A0A2K5U1H6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:LOC102127617
gene id: 9541:LOC102127617
uniprot id: A0A2K5UY76
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9541:MRPL19
gene id: 9541:MRPL19
uniprot id: A0A2K5VJ67
uniprot id: G8F3A1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9541:TSPYL4
gene id: 9541:TSPYL4
uniprot id: Q9BDD7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:SOX14
gene id: 9541:SOX14
uniprot id: G7P040
uniprot id: P61259
names: Function
names: Subcellular Location Annotation
messages: Acts as a negative regulator of transcription.
messages: Nucleus

9541:PRAF2
gene id: 9541:PRAF2
uniprot id: G7Q2P6
uniprot id: Q4R4I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Endosome membrane
messages: Interacts with CCR5 and GDE1.
messages: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).
messages: Membrane

9541:USO1
gene id: 9541:USO1
uniprot id: A0A2K5WJH1
uniprot id: A0A2K5WJK0
uniprot id: A0A2K5WJV7
uniprot id: A0A7N9CYF0
uniprot id: G7P562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9541:LOC102115890
gene id: 9541:LOC102115890
uniprot id: A0A2K5UPS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9541:CMA1
gene id: 9541:CMA1
uniprot id: P56435
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Granzyme subfamily.
messages: Cytoplasmic granule
messages: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
messages: Secreted

9541:LOC102142158
gene id: 9541:LOC102142158
uniprot id: A0A2K5WPZ6
names: Subunit
messages: Monomer.

9541:NFKB1
gene id: 9541:NFKB1
uniprot id: A0A2K5TPZ9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:LOC102121032
gene id: 9541:LOC102121032
uniprot id: G7PRS7
names: Subcellular Location Annotation
messages: Membrane

9541:SERPINB12
gene id: 9541:SERPINB12
uniprot id: A0A2K5VRK4
names: Similarity
messages: Belongs to the serpin family.

9541:LOC102119629
gene id: 9541:LOC102119629
uniprot id: G7PS84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CHMP5
gene id: 9541:CHMP5
uniprot id: A0A8J8XNK1
uniprot id: G7PS50
names: Similarity
messages: Belongs to the SNF7 family.

9541:TP53RK
gene id: 9541:TP53RK
uniprot id: G7PG31
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9541:PCSK5
gene id: 9541:PCSK5
uniprot id: A0A2K5X4Q2
uniprot id: A0A2K5X4W2
names: Similarity
messages: Belongs to the peptidase S8 family.

9541:CALY
gene id: 9541:CALY
uniprot id: A0A2K5WDP1
names: Similarity
messages: Belongs to the NSG family.

9541:SLC5A1
gene id: 9541:SLC5A1
uniprot id: A0A2K5VYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9541:MRPL35
gene id: 9541:MRPL35
uniprot id: A0A7N9D929
uniprot id: G8F3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9541:TLCD4
gene id: 9541:TLCD4
uniprot id: A0A8J8XS27
uniprot id: G7NV14
names: Subcellular Location Annotation
messages: Membrane

9541:VPS18
gene id: 9541:VPS18
uniprot id: A0A2K5U7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9541:IL12B
gene id: 9541:IL12B
uniprot id: G7P6S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
messages: Secreted

9541:ACVR2B
gene id: 9541:ACVR2B
uniprot id: A0A2K5WUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:AKAP9
gene id: 9541:AKAP9
uniprot id: A0A2K5UQE0
names: Subcellular Location Annotation
messages: centrosome

9541:DCST2
gene id: 9541:DCST2
uniprot id: A0A2K5VG69
names: Subcellular Location Annotation
messages: Membrane

9541:NOS2
gene id: 9541:NOS2
uniprot id: A0A2K5V3D8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9541:ATP5PB
gene id: 9541:ATP5PB
uniprot id: A0A2K5TRC9
uniprot id: A0A2K5TRE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9541:GJB2
gene id: 9541:GJB2
uniprot id: A0A2K5UFL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:CFAP418
gene id: 9541:CFAP418
uniprot id: A0A2K5VME6
uniprot id: G7PC93
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9541:AKAP4
gene id: 9541:AKAP4
uniprot id: A0A2K5TTC4
uniprot id: A0A7N9D580
names: Similarity
messages: Belongs to the AKAP110 family.

9541:ZDHHC14
gene id: 9541:ZDHHC14
uniprot id: A0A2K5VVN3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:ETV7
gene id: 9541:ETV7
uniprot id: A0A2K5U639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:TECR
gene id: 9541:TECR
uniprot id: I7GD06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:HSD17B7
gene id: 9541:HSD17B7
uniprot id: Q2XQY1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9541:EYA1
gene id: 9541:EYA1
uniprot id: A0A2K5UQ80
uniprot id: A0A2K5UQA5
uniprot id: A0A8J8Y0Y3
uniprot id: G7PC08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9541:GCSH
gene id: 9541:GCSH
uniprot id: A0A8J8YM65
uniprot id: G7PZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:ANXA11
gene id: 9541:ANXA11
uniprot id: A0A2K5VTK4
uniprot id: G7PEX7
uniprot id: I7GH43
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:ORAI3
gene id: 9541:ORAI3
uniprot id: A0A2K5TPV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9541:PTGDS
gene id: 9541:PTGDS
uniprot id: Q4R5N0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Membrane
messages: Monomer.
messages: Nucleus membrane
messages: Rough endoplasmic reticulum
messages: perinuclear region

9541:EEF1D
gene id: 9541:EEF1D
uniprot id: A0A2K5WG05
uniprot id: A0A805R9Y0
uniprot id: Q4R3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2 (By similarity).
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
messages: Nucleus
messages: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

9541:MBOAT2
gene id: 9541:MBOAT2
uniprot id: A0A2K5WBM1
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102138082
gene id: 9541:LOC102138082
uniprot id: A0A2K5TLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9541:ALKBH5
gene id: 9541:ALKBH5
uniprot id: A0A2K5TU23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Monomer.
messages: Nucleus speckle

9541:DENND10
gene id: 9541:DENND10
uniprot id: A0A7N9CX28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9541:MRPL22
gene id: 9541:MRPL22
uniprot id: A0A2K5TTD7
uniprot id: G7P6Q4
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9541:CALHM6
gene id: 9541:CALHM6
uniprot id: A0A8J8Y2T0
uniprot id: G7P3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:CLDN12
gene id: 9541:CLDN12
uniprot id: A0A2K5UH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9541:AGPAT2
gene id: 9541:AGPAT2
uniprot id: A0A2K5WF11
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9541:DSC2
gene id: 9541:DSC2
uniprot id: A0A2K5VRM5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9541:MGAT5B
gene id: 9541:MGAT5B
uniprot id: A0A2K5WKS2
uniprot id: A0A2K5WKT5
uniprot id: A0A2K5WL55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102120205
gene id: 9541:LOC102120205
uniprot id: A0A2K5UN65
uniprot id: G7P0Q2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9541:GABRR1
gene id: 9541:GABRR1
uniprot id: A0A2K5TTB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:KIF12
gene id: 9541:KIF12
uniprot id: A0A2K5X5K7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:TMEM175
gene id: 9541:TMEM175
uniprot id: A0A2K5VXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9541:PDGFRL
gene id: 9541:PDGFRL
uniprot id: Q2PFX1
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

9541:PIK3CD
gene id: 9541:PIK3CD
uniprot id: A0A2K5TKS9
uniprot id: A0A7N9CY41
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:USE1
gene id: 9541:USE1
uniprot id: A0A2K5X308
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CAST
gene id: 9541:CAST
uniprot id: A0A2K5V7W1
uniprot id: A0A2K5V7W9
uniprot id: A0A2K5V7X1
uniprot id: A0A2K5V7Y2
uniprot id: A0A2K5V839
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9541:C1QA
gene id: 9541:C1QA
uniprot id: A0A2K5WJV6
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9541:PYM1
gene id: 9541:PYM1
uniprot id: A0A2K5W7E5
uniprot id: A0A2K5W7I1
uniprot id: G7PIF7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9541:CSRNP1
gene id: 9541:CSRNP1
uniprot id: A0A2K5U8N7
uniprot id: A0A7N9CWX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9541:ATG5
gene id: 9541:ATG5
uniprot id: A0A2K5WVV4
uniprot id: A0A2K5WW04
uniprot id: A0A8J8Y5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9541:ZNF263
gene id: 9541:ZNF263
uniprot id: A0A2K5UTS6
names: Subcellular Location Annotation
messages: Nucleus

9541:FSD1
gene id: 9541:FSD1
uniprot id: Q4R539
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: B30.2 box contains a microtubule-binding site.
messages: Cleavage furrow
messages: Cytoplasm
messages: May be involved in microtubule organization and stabilization.
messages: Nucleus
messages: Oligomerization is required for binding to microtubules.
messages: centrosome

9541:MC1R
gene id: 9541:MC1R
uniprot id: A3KF54
uniprot id: A3KF60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.

9541:ZSCAN1
gene id: 9541:ZSCAN1
uniprot id: A0A2K5UUD4
names: Subcellular Location Annotation
messages: Nucleus

9541:SEPTIN4
gene id: 9541:SEPTIN4
uniprot id: A0A2K5WM76
uniprot id: A0A2K5WMG6
uniprot id: A0A2K5WN04
uniprot id: I7GNK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:TAFA4
gene id: 9541:TAFA4
uniprot id: A0A2K5UI35
uniprot id: A0A7N9D012
uniprot id: Q9N0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAFA family.
messages: Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
messages: Secreted

9541:LOC102136630
gene id: 9541:LOC102136630
uniprot id: A0A2K5VI12
uniprot id: A0A2K5VI22
uniprot id: A0A2K5VI59
uniprot id: A0A2K5VI65
uniprot id: A0A2K5VI79
uniprot id: A0A2K5VI87
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9541:MRPL50
gene id: 9541:MRPL50
uniprot id: A0A7N9D744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9541:ITPKA
gene id: 9541:ITPKA
uniprot id: A0A2K5WY52
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:EPHA1
gene id: 9541:EPHA1
uniprot id: A0A2K5WPT2
names: Subcellular Location Annotation
messages: Membrane

9541:ASF1A
gene id: 9541:ASF1A
uniprot id: A0A2K5VAE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9541:MAB21L1
gene id: 9541:MAB21L1
uniprot id: A0A2K5TP07
names: Similarity
messages: Belongs to the mab-21 family.

9541:TRPC3
gene id: 9541:TRPC3
uniprot id: A0A2K5X8G6
uniprot id: A0A2K5X8K7
names: Subcellular Location Annotation
messages: Membrane

9541:UPK1B
gene id: 9541:UPK1B
uniprot id: A0A8J8YPH5
uniprot id: G7NXN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9541:GCFC2
gene id: 9541:GCFC2
uniprot id: A0A2K5VJ98
names: Similarity
messages: Belongs to the GCF family.

9541:CLIC5
gene id: 9541:CLIC5
uniprot id: A0A2K5UCD5
uniprot id: A0A2K5UCE6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9541:FGF8
gene id: 9541:FGF8
uniprot id: A0A2K5WBN1
uniprot id: A0A2K5WBU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9541:PXMP2
gene id: 9541:PXMP2
uniprot id: A0A2K5TV73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9541:LOC102123567
gene id: 9541:LOC102123567
uniprot id: A0A2K5V040
uniprot id: A0A2K5V0A2
names: Similarity
messages: Belongs to the LEO1 family.

9541:ATP1A1
gene id: 9541:ATP1A1
uniprot id: A0A2K5WIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9541:LOC102131730
gene id: 9541:LOC102131730
uniprot id: A0A2K5V997
names: Similarity
messages: Belongs to the serpin family.

9541:ZNF18
gene id: 9541:ZNF18
uniprot id: A0A2K5VB21
names: Subcellular Location Annotation
messages: Nucleus

9541:SSR1
gene id: 9541:SSR1
uniprot id: A0A2K5X4H4
uniprot id: Q4R4P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9541:HDAC5
gene id: 9541:HDAC5
uniprot id: A0A2K5VGF8
uniprot id: A0A2K5VGP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9541:ENO1
gene id: 9541:ENO1
uniprot id: A0A2K5VXB8
uniprot id: Q4R5L2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.
messages: Cell membrane
messages: Cytoplasm
messages: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
messages: ISGylated.
messages: Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.
messages: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding. Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (By similarity).

9541:VILL
gene id: 9541:VILL
uniprot id: A0A2K5TXC1
names: Similarity
messages: Belongs to the villin/gelsolin family.

9541:FOXP2
gene id: 9541:FOXP2
uniprot id: A0A2K5X941
names: Subcellular Location Annotation
messages: Nucleus

9541:NTRK2
gene id: 9541:NTRK2
uniprot id: A0A2K5VS06
uniprot id: A0A2K5VS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:ELMO3
gene id: 9541:ELMO3
uniprot id: A0A2K5WQB0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9541:S1PR1
gene id: 9541:S1PR1
uniprot id: A0A2K5UHU7
uniprot id: A0A7N9I9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102127523
gene id: 9541:LOC102127523
uniprot id: A0A2K5UBT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SOAT2
gene id: 9541:SOAT2
uniprot id: A0A2K5V656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ROPN1L
gene id: 9541:ROPN1L
uniprot id: Q4R760
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ropporin family.
messages: Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
messages: May interact with AKAP3 (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).
messages: Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.
messages: cilium
messages: flagellum

9541:ADK
gene id: 9541:ADK
uniprot id: A0A2K5VIG9
uniprot id: A0A2K5VIH5
uniprot id: A0A2K5VIJ9
uniprot id: A0A7N9D543
uniprot id: A0A7N9D865
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9541:CDCA7
gene id: 9541:CDCA7
uniprot id: A0A2K5TND4
uniprot id: A0A2K5TND6
uniprot id: A0A8J8XQ54
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:USP7
gene id: 9541:USP7
uniprot id: A0A2K5X1Z9
uniprot id: A0A2K5X2D8
uniprot id: A0A2K5X2E2
names: Similarity
messages: Belongs to the peptidase C19 family.

9541:LIN7A
gene id: 9541:LIN7A
uniprot id: A0A2K5X044
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9541:RIMKLA
gene id: 9541:RIMKLA
uniprot id: A0A2K5VKU1
names: Similarity
messages: Belongs to the RimK family.

9541:ZNF322
gene id: 9541:ZNF322
uniprot id: Q4R7X8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Interacts with POU5F1.
messages: Nucleus
messages: Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process.
messages: Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation.

9541:PITPNM1
gene id: 9541:PITPNM1
uniprot id: A0A2K5WS36
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9541:DDB1
gene id: 9541:DDB1
uniprot id: A0A2K5VZB4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9541:LOC102131735
gene id: 9541:LOC102131735
uniprot id: A0A2K5TR24
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102122191
gene id: 9541:LOC102122191
uniprot id: A0A2K5UFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9541:DRAXIN
gene id: 9541:DRAXIN
uniprot id: A0A2K5X1K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
messages: Interacts with LRP6.
messages: Secreted

9541:RBL2
gene id: 9541:RBL2
uniprot id: A0A2K5X2M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9541:CLN3
gene id: 9541:CLN3
uniprot id: A0A2K5X0H7
uniprot id: A0A2K5X0Y0
uniprot id: I7G3Q7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9541:SLC33A1
gene id: 9541:SLC33A1
uniprot id: I7GL61
names: Subcellular Location Annotation
messages: Membrane

9541:HNRNPD
gene id: 9541:HNRNPD
uniprot id: A0A2K5UXA3
uniprot id: A0A2K5UXA5
uniprot id: A0A2K5UXI0
uniprot id: A0A7N9DEU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:AASS
gene id: 9541:AASS
uniprot id: A0A2K5WM48
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9541:SLC35B1
gene id: 9541:SLC35B1
uniprot id: A0A8J8Y4I0
uniprot id: G7PU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9541:CDK6
gene id: 9541:CDK6
uniprot id: A0A8J8XB64
uniprot id: G7P1D7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:RPL22L1
gene id: 9541:RPL22L1
uniprot id: A0A2K5WVQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9541:PADI1
gene id: 9541:PADI1
uniprot id: A0A8J8YFJ7
uniprot id: G7NUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9541:STN1
gene id: 9541:STN1
uniprot id: G7PDW8
uniprot id: Q4R804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
messages: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1. Interacts with ACD/TPP1, POT1 and POLA1.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9541:MAPK1IP1L
gene id: 9541:MAPK1IP1L
uniprot id: Q4R837
names: Similarity
messages: Belongs to the MISS family.

9541:TRAPPC5
gene id: 9541:TRAPPC5
uniprot id: I7GAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9541:TNC
gene id: 9541:TNC
uniprot id: A0A2K5TX89
uniprot id: A0A2K5TXA7
uniprot id: A0A2K5TXC7
uniprot id: A0A2K5TXD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:PLPPR2
gene id: 9541:PLPPR2
uniprot id: A0A2K5WHK0
uniprot id: G7PZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:CLP1
gene id: 9541:CLP1
uniprot id: G7PQ31
uniprot id: Q4R7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

9541:POMGNT2
gene id: 9541:POMGNT2
uniprot id: A0A2K5UFV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:KCNV2
gene id: 9541:KCNV2
uniprot id: A0A2K5WVN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:PDE1A
gene id: 9541:PDE1A
uniprot id: A0A2K5WGG4
uniprot id: A0A2K5WGH9
uniprot id: A0A2K5WGI0
uniprot id: A0A2K5WGQ6
uniprot id: A0A7N9CCQ5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:DUSP13
gene id: 9541:DUSP13
uniprot id: A0A2K5UMJ2
uniprot id: A0A2K5UMJ6
uniprot id: A0A2K5UMN5
uniprot id: A0A7N9C7Z2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9541:CORO7
gene id: 9541:CORO7
uniprot id: A0A2K5UTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9541:CENPT
gene id: 9541:CENPT
uniprot id: G7Q1E8
uniprot id: Q4R5U8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-T/CNN1 family.
messages: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts (via N-terminus) with the NDC80 complex. Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex.
messages: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
messages: Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.
messages: Nucleus
messages: The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.
messages: centromere
messages: kinetochore

9541:SLC5A2
gene id: 9541:SLC5A2
uniprot id: A0A2K5TZ85
uniprot id: A0A2K5TZ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9541:MED24
gene id: 9541:MED24
uniprot id: A0A2K5W2W8
uniprot id: A0A2K5W2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9541:ABRAXAS1
gene id: 9541:ABRAXAS1
uniprot id: A0A2K5X6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9541:IL25
gene id: 9541:IL25
uniprot id: A0A2K5TY65
uniprot id: G7P9V9
names: Similarity
messages: Belongs to the IL-17 family.

9541:SIRT6
gene id: 9541:SIRT6
uniprot id: A0A2K5TU92
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-33. Deacetylation at Lys-33 by SIRT1 promotes homomultimerization and binding to double-strand breaks (DSBs) sites.
messages: Belongs to the sirtuin family. Class IV subfamily.
messages: Chromosome
messages: Compared to the defatty-acylase activity, the protein deacetylase activity is weak in vitro, and requires activation. The histone deacetylase activity is strongly activated upon binding to nucleosomes and chromatin in vivo. Two molecules of SIRT6 associate with the acidic patch of one nucleosome, while the C-terminal disordered region of SIRT6 associates with nucleosomal DNA, leading to efficient histone deacetylation. The protein-lysine deacetylase activity is also activated by long-chain free fatty-acids.
messages: Endoplasmic reticulum
messages: Homodimer; binds to nucleosomes and DNA ends as a homodimer (By similarity). Interacts with RELA; interferes with RELA binding to target DNA (By similarity). Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites (By similarity). Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1. Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes. Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus (By similarity).
messages: Monkeys die soon after birth and exhibit severe prenatal developmental retardation (PubMed:30135584). The molecular developmental stage of the monkeys mimics that of wild-type fetuses at 2-4 months of gestational age (PubMed:30135584). Neuronal differentiation is strongly delayed, due to hyperacetylation of histone H3 at 'Lys-56' (H3K56ac), leading to up-regulation of the long non-coding RNA H19 (PubMed:30135584).
messages: Monoubiquitinated at Lys-170 by STUB1/CHIP, preventing its degradation by the proteasome.
messages: NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:30135584). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (By similarity). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:30135584). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (By similarity). SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (By similarity). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (By similarity). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (By similarity). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (By similarity). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (By similarity). Inhibit…
messages: Nucleus
messages: Phosphorylation at Ser-10 by MAPK8/JNK1 in response to oxidative stress stimulates the mono-ADP-ribosyltransferase activity on PARP1, leading to PARP1 recruitment to double-strand breaks (DSBs).
messages: Sumoylated, leading to specifically decrease ability to deacetylate histone H3 at 'Lys-56' (H3K56ac).
messages: The C-terminal disordered region mediates non-specific DNA-binding.
messages: telomere

9541:TRIM25
gene id: 9541:TRIM25
uniprot id: A0A2K5WDN3
uniprot id: G7PUD8
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9541:LOC102123447
gene id: 9541:LOC102123447
uniprot id: A0A2K5UBM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9541:TTC4
gene id: 9541:TTC4
uniprot id: A0A2K5VVM5
names: Similarity
messages: Belongs to the TTC4 family.

9541:GJB4
gene id: 9541:GJB4
uniprot id: G7NTG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:CREM
gene id: 9541:CREM
uniprot id: A0A2K5VK43
uniprot id: A0A2K5VKH5
uniprot id: A0A2K5VKH8
uniprot id: A0A2K5VKI3
uniprot id: A0A2K5VKI5
uniprot id: A0A2K5VKL3
uniprot id: A0A7N9DAB8
names: Subcellular Location Annotation
messages: Nucleus

9541:ESAM
gene id: 9541:ESAM
uniprot id: Q95KI3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can mediate aggregation most likely through a homophilic molecular interaction.
messages: Cell membrane
messages: Interacts with MAGI1.
messages: adherens junction
messages: tight junction

9541:VPS29
gene id: 9541:VPS29
uniprot id: A0A2K5U0S8
uniprot id: A0A2K5U0U4
uniprot id: A0A2K5U0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9541:MAK16
gene id: 9541:MAK16
uniprot id: A0A2K5UUL8
names: Similarity
messages: Belongs to the MAK16 family.

9541:COL4A3
gene id: 9541:COL4A3
uniprot id: A0A2K5U207
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9541:CCNT1
gene id: 9541:CCNT1
uniprot id: A0A2K5W0G8
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9541:ATP5F1B
gene id: 9541:ATP5F1B
uniprot id: A0A2K5WEF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9541:MINDY3
gene id: 9541:MINDY3
uniprot id: A0A7N9CXL7
uniprot id: G7PEF7
uniprot id: Q4R528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Interacts with COPS5.
messages: Nucleus

9541:MAN2C1
gene id: 9541:MAN2C1
uniprot id: A0A2K5U911
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

9541:GINS4
gene id: 9541:GINS4
uniprot id: A0A8J8XEM9
uniprot id: G7PD92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9541:ADGRA3
gene id: 9541:ADGRA3
uniprot id: A0A2K5USY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9541:LOC102129434
gene id: 9541:LOC102129434
uniprot id: A0A2K5UDR6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9541:NDUFA10
gene id: 9541:NDUFA10
uniprot id: A0A2K5TTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9541:NKX6-2
gene id: 9541:NKX6-2
uniprot id: A0A2K5VUM2
names: Subcellular Location Annotation
messages: Nucleus

9541:ERBB3
gene id: 9541:ERBB3
uniprot id: A0A8J8XF73
uniprot id: G7PIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9541:MOG
gene id: 9541:MOG
uniprot id: Q29ZP0
uniprot id: Q29ZP1
uniprot id: Q29ZP6
uniprot id: Q29ZP7
uniprot id: Q9BGS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9541:CFHR5
gene id: 9541:CFHR5
uniprot id: A0A2K5WEG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:HOXA4
gene id: 9541:HOXA4
uniprot id: A0A2K5TKG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:TRNT1
gene id: 9541:TRNT1
uniprot id: A0A2K5VRQ5
uniprot id: G7NYX0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9541:DCTD
gene id: 9541:DCTD
uniprot id: A0A2K5WHP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

9541:ASAH1
gene id: 9541:ASAH1
uniprot id: I7GEN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9541:PEX7
gene id: 9541:PEX7
uniprot id: A0A2K5W3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

9541:PTGR2
gene id: 9541:PTGR2
uniprot id: A0A2K5WQJ4
uniprot id: A0A7N9DCK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9541:PLIN2
gene id: 9541:PLIN2
uniprot id: A0A2K5VXC7
names: Similarity
messages: Belongs to the perilipin family.

9541:SPOCK1
gene id: 9541:SPOCK1
uniprot id: A0A2K5WZ19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RBPJ
gene id: 9541:RBPJ
uniprot id: A0A2K5TVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9541:PALS2
gene id: 9541:PALS2
uniprot id: A0A2K5UJF0
uniprot id: A0A2K5UJH6
uniprot id: Q4R7B5
uniprot id: Q4R814
names: Similarity
messages: Belongs to the MAGUK family.

9541:STMN3
gene id: 9541:STMN3
uniprot id: Q4R4N5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
messages: Golgi apparatus
messages: Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).
messages: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).
messages: axon
messages: cytosol
messages: growth cone

9541:ATP5MC3
gene id: 9541:ATP5MC3
uniprot id: G7PKV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9541:AGBL2
gene id: 9541:AGBL2
uniprot id: Q4R632
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Inhibited by RARRES1.
messages: Interacts with RARRES1, KIF11 and MAPRE1.
messages: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
messages: Was initially shown to catalyze the removal of carboxy-terminus tyrosine from alpha-tubulin (By similarity). However, later studies did not identified any detyrosinase or deglycylase activities from the carboxy-terminus of tubulin (By similarity).
messages: Was originally thought to have detyrosinating activity from C-terminal positions on tubulin.
messages: centriole
messages: cilium basal body
messages: cytosol

9541:GLYCTK
gene id: 9541:GLYCTK
uniprot id: A0A2K5V6G9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9541:MAP2K5
gene id: 9541:MAP2K5
uniprot id: A0A2K5UQ60
uniprot id: Q2PFR6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CYP2C76
gene id: 9541:CYP2C76
uniprot id: Q0HA17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:PFN2
gene id: 9541:PFN2
uniprot id: Q4R4P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (By similarity).
messages: cytoskeleton

9541:NDUFAF3
gene id: 9541:NDUFAF3
uniprot id: A0A8J8Y929
uniprot id: G7NXV0
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9541:STAG1
gene id: 9541:STAG1
uniprot id: A0A2K5WHU2
uniprot id: A0A8J8XEF3
uniprot id: G7NXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9541:PIK3C2B
gene id: 9541:PIK3C2B
uniprot id: A0A2K5W9G8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:RDH8
gene id: 9541:RDH8
uniprot id: A0A8J8YHB7
uniprot id: G7PZ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9541:HIGD1A
gene id: 9541:HIGD1A
uniprot id: A0A8J8YGQ2
uniprot id: G7NY64
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:NPL
gene id: 9541:NPL
uniprot id: A0A2K5WFI8
uniprot id: A0A8J8XEN5
uniprot id: G7NXG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9541:CFAP45
gene id: 9541:CFAP45
uniprot id: A0A2K5VWS4
uniprot id: Q4R8K2
names: Similarity
messages: Belongs to the CFAP45 family.

9541:SLC2A12
gene id: 9541:SLC2A12
uniprot id: Q9BE72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Insulin-independent facilitative glucose transporter.
messages: perinuclear region

9541:LOC102130508
gene id: 9541:LOC102130508
uniprot id: A0A8J8Y0N3
uniprot id: G7PP72
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9541:GHRL
gene id: 9541:GHRL
uniprot id: A0A2K5VHC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9541:TMEM233
gene id: 9541:TMEM233
uniprot id: A0A7N9D303
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:PDE4B
gene id: 9541:PDE4B
uniprot id: A0A2K5U5W0
uniprot id: A0A2K5U5Z5
uniprot id: A0A8J8YHZ4
uniprot id: G7NW27
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:PACSIN2
gene id: 9541:PACSIN2
uniprot id: A0A2K5WWB5
uniprot id: A0A2K5WWJ9
uniprot id: G7PFV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9541:SLC26A4
gene id: 9541:SLC26A4
uniprot id: A0A2K5WWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9541:LOC102138926
gene id: 9541:LOC102138926
uniprot id: A0A2K5VPU0
names: Similarity
messages: Belongs to the PRAME family.

9541:CCL25
gene id: 9541:CCL25
uniprot id: A0A2K5TSD9
names: Subcellular Location Annotation
messages: Secreted

9541:SLC24A4
gene id: 9541:SLC24A4
uniprot id: A0A2K5WJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9541:SH2B3
gene id: 9541:SH2B3
uniprot id: A0A7N9CRG6
names: Similarity
messages: Belongs to the SH2B adapter family.

9541:MAGEB18
gene id: 9541:MAGEB18
uniprot id: Q4R998
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with LNX1.
messages: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).

9541:MANEA
gene id: 9541:MANEA
uniprot id: A0A8J8YEI5
uniprot id: G7P424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102138874
gene id: 9541:LOC102138874
uniprot id: A0A2K5TNE4
names: Similarity
messages: Belongs to the MHC class I family.

9541:CYP2C18
gene id: 9541:CYP2C18
uniprot id: A0A2K5UX32
uniprot id: E0V8I6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:LMNA
gene id: 9541:LMNA
uniprot id: A0A8J8YBF0
uniprot id: G7NV78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9541:PSMC4
gene id: 9541:PSMC4
uniprot id: G7PXK9
uniprot id: Q4R7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC4 and few additional components. Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5. Interacts with ZFAND1 (By similarity).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Nucleus

9541:B3GALT4
gene id: 9541:B3GALT4
uniprot id: I7GK51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:PIAS1
gene id: 9541:PIAS1
uniprot id: Q4R996
names: Similarity
messages: Belongs to the PIAS family.

9541:CAVIN4
gene id: 9541:CAVIN4
uniprot id: A0A2K5VJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9541:RET
gene id: 9541:RET
uniprot id: A0A2K5V8L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9541:LARP7
gene id: 9541:LARP7
uniprot id: A0A2K5TMC6
uniprot id: Q4R627
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LARP7 family.
messages: Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with METTL16. Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.
messages: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (By similarity).
messages: The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
messages: nucleoplasm

9541:DNAJC2
gene id: 9541:DNAJC2
uniprot id: G7P1Y7
uniprot id: Q4R8H2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2 (By similarity). Interacts (via ZRF1-UBD region) with ID1 (By similarity).
messages: Nucleus
messages: Phosphorylated in M (mitotic) phase.
messages: The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
messages: cytosol

9541:EXOC4
gene id: 9541:EXOC4
uniprot id: A0A2K5V2F7
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:LOC102114846
gene id: 9541:LOC102114846
uniprot id: A0A023JCA5
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9541:SLC38A11
gene id: 9541:SLC38A11
uniprot id: Q8HXI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane
messages: Putative sodium-dependent amino acid/proton antiporter.

9541:LOC102124081
gene id: 9541:LOC102124081
uniprot id: A0A2K5UF96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SRFBP1
gene id: 9541:SRFBP1
uniprot id: A0A2K5UUL1
uniprot id: A0A2K5UUQ8
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9541:CGAS
gene id: 9541:CGAS
uniprot id: A0A2K5WT00
names: Similarity
messages: Belongs to the mab-21 family.

9541:RIOX2
gene id: 9541:RIOX2
uniprot id: A0A2K5VVK1
uniprot id: G7NZ70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

9541:WRNIP1
gene id: 9541:WRNIP1
uniprot id: A0A2K5U7J6
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9541:CLCC1
gene id: 9541:CLCC1
uniprot id: A0A2K5X6M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9541:NMT1
gene id: 9541:NMT1
uniprot id: A0A2K5VEF7
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9541:FAM200A
gene id: 9541:FAM200A
uniprot id: Q4R6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM200 family.
messages: Membrane

9541:LOC102138266
gene id: 9541:LOC102138266
uniprot id: A0A2K5VZK6
names: Similarity
messages: Belongs to the PP2C family.

9541:TSSK2
gene id: 9541:TSSK2
uniprot id: Q4R8P4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:FZD2
gene id: 9541:FZD2
uniprot id: A0A2K5WLJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PDE5A
gene id: 9541:PDE5A
uniprot id: A0A2K5U205
uniprot id: A0A2K5U243
uniprot id: A0A8J8Y3N4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:LOC102130817
gene id: 9541:LOC102130817
uniprot id: A0A0H3UJW9
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9541:GH1
gene id: 9541:GH1
uniprot id: A0A2K5WEW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9541:CD200R1
gene id: 9541:CD200R1
uniprot id: A0A2K5WLV7
uniprot id: A0A2K5WLW2
uniprot id: G7NZT0
names: Similarity
messages: Belongs to the CD200R family.

9541:TFEC
gene id: 9541:TFEC
uniprot id: A0A2K5V9X1
uniprot id: A0A2K5VA00
uniprot id: A0A7N9CGQ0
uniprot id: G7P2I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:DEFB128
gene id: 9541:DEFB128
uniprot id: A4H255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:EIF2B5
gene id: 9541:EIF2B5
uniprot id: A0A2K5VUN2
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9541:LY6G5C
gene id: 9541:LY6G5C
uniprot id: A0A7N9CQK9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9541:MARCO
gene id: 9541:MARCO
uniprot id: A0A2K5X0Z2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CERT1
gene id: 9541:CERT1
uniprot id: A0A2K5URZ1
uniprot id: A0A2K5US20
uniprot id: A0A7N9CN24
uniprot id: A0A8J8Y6D8
uniprot id: G7P7R6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9541:ELF1
gene id: 9541:ELF1
uniprot id: A0A8J8YI97
uniprot id: G7PW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:LIPA
gene id: 9541:LIPA
uniprot id: A0A2K5VBG9
uniprot id: Q4R4S5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.
messages: Glycosylation is not essential for catalytic activity.
messages: Lysosome
messages: Monomer.

9541:SLC25A17
gene id: 9541:SLC25A17
uniprot id: A0A2K5VCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LOC102134405
gene id: 9541:LOC102134405
uniprot id: A0A2K5X2M0
names: Similarity
messages: Belongs to the intermediate filament family.

9541:BRPF1
gene id: 9541:BRPF1
uniprot id: A0A2K5VVC2
uniprot id: A0A8J8XYP3
uniprot id: G7NYU9
names: Subcellular Location Annotation
messages: Nucleus

9541:STXBP5
gene id: 9541:STXBP5
uniprot id: A0A2K5TXA1
uniprot id: A0A2K5TXA4
uniprot id: A0A2K5TXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9541:BLCAP
gene id: 9541:BLCAP
uniprot id: A0A7N9CIA7
uniprot id: A0A8J8Y731
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9541:SNX8
gene id: 9541:SNX8
uniprot id: A0A2K5UMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9541:LOC102118628
gene id: 9541:LOC102118628
uniprot id: A0A2K5U5T0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:MPO
gene id: 9541:MPO
uniprot id: A0A2K5UPZ9
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9541:TMEM45A
gene id: 9541:TMEM45A
uniprot id: A0A8J8Y5X3
uniprot id: G7NZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9541:TM6SF2
gene id: 9541:TM6SF2
uniprot id: A0A2K5UD60
names: Subcellular Location Annotation
messages: Membrane

9541:RPRD1A
gene id: 9541:RPRD1A
uniprot id: A0A2K5TPT9
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9541:GPC6
gene id: 9541:GPC6
uniprot id: A0A2K5VNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9541:TNFSF13B
gene id: 9541:TNFSF13B
uniprot id: A0A2K5V2X4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:CPT2
gene id: 9541:CPT2
uniprot id: Q60HG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
messages: Mitochondrion inner membrane

9541:MARK1
gene id: 9541:MARK1
uniprot id: A0A2K5X332
uniprot id: A0A2K5X343
uniprot id: A0A2K5X387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9541:RRP12
gene id: 9541:RRP12
uniprot id: A0A2K5WXV4
uniprot id: G7PDN9
names: Similarity
messages: Belongs to the RRP12 family.

9541:KIF15
gene id: 9541:KIF15
uniprot id: A0A2K5WY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

9541:LOC102121807
gene id: 9541:LOC102121807
uniprot id: A0A2K5UGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CLEC12A
gene id: 9541:CLEC12A
uniprot id: A0A2K5WXQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:PLEKHA8
gene id: 9541:PLEKHA8
uniprot id: G7P0H6
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9541:STX6
gene id: 9541:STX6
uniprot id: A0A2K5V4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9541:DGAT2L6
gene id: 9541:DGAT2L6
uniprot id: A0A2K5X0C2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MSMB
gene id: 9541:MSMB
uniprot id: A0A2K5WFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9541:SEPSECS
gene id: 9541:SEPSECS
uniprot id: A0A2K5WAA0
uniprot id: G7P5C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9541:GPBP1
gene id: 9541:GPBP1
uniprot id: A0A2K5TL91
uniprot id: A0A8J8YGF1
uniprot id: G7P7J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9541:TMEM39B
gene id: 9541:TMEM39B
uniprot id: A0A2K5TPN6
uniprot id: A0A2K5TPQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9541:KLHL36
gene id: 9541:KLHL36
uniprot id: A0A2K5VUK0
names: Function
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9541:ZNF500
gene id: 9541:ZNF500
uniprot id: A0A2K5V409
names: Subcellular Location Annotation
messages: Nucleus

9541:SLA
gene id: 9541:SLA
uniprot id: A0A2K5W9Z8
uniprot id: I7G5L0
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CTNS
gene id: 9541:CTNS
uniprot id: A0A2K5U1W1
uniprot id: A0A2K5U1Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9541:TBX10
gene id: 9541:TBX10
uniprot id: A0A2K5UDB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:UNC5CL
gene id: 9541:UNC5CL
uniprot id: A0A2K5V3E7
names: Similarity
messages: Belongs to the unc-5 family.

9541:ARRDC2
gene id: 9541:ARRDC2
uniprot id: A0A2K5WC33
uniprot id: A0A2K5WC63
names: Similarity
messages: Belongs to the arrestin family.

9541:DMGDH
gene id: 9541:DMGDH
uniprot id: A0A2K5UJ46
names: Similarity
messages: Belongs to the GcvT family.

9541:ITGA9
gene id: 9541:ITGA9
uniprot id: A0A2K5U396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:MEF2A
gene id: 9541:MEF2A
uniprot id: A0A2K5VXR6
uniprot id: A0A2K5VXV0
names: Subcellular Location Annotation
messages: Nucleus

9541:ALG2
gene id: 9541:ALG2
uniprot id: A0A2K5W716
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9541:GTPBP10
gene id: 9541:GTPBP10
uniprot id: A0A2K5UHT5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9541:FUNDC2
gene id: 9541:FUNDC2
uniprot id: I7GEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9541:MLN
gene id: 9541:MLN
uniprot id: A0A2K5V0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9541:LOC102117500
gene id: 9541:LOC102117500
uniprot id: A0A2K5WNM3
names: Similarity
messages: Belongs to the HPF1 family.

9541:LY75
gene id: 9541:LY75
uniprot id: A0A2K5W1W8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NANOG
gene id: 9541:NANOG
uniprot id: Q5TM84
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nanog homeobox family.
messages: Expressed in embryonic stem (ES) cells.
messages: Interacts with SMAD1. Interacts with SALL4. Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (By similarity). Interacts with ESRRB; reciprocally modulates their transcriptional activities. Interacts with NSD2 (By similarity).
messages: Nucleus
messages: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

9541:NPNT
gene id: 9541:NPNT
uniprot id: A0A2K5WQS9
uniprot id: A0A2K5WQT3
uniprot id: A0A2K5WR90
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SGO2
gene id: 9541:SGO2
uniprot id: A0A2K5VWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9541:LOC102135947
gene id: 9541:LOC102135947
uniprot id: A0A2K5WWN3
names: Similarity
messages: Belongs to the histone H2B family.

9541:STT3B
gene id: 9541:STT3B
uniprot id: A0A2K5VVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9541:NSUN2
gene id: 9541:NSUN2
uniprot id: A0A2K5VSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9541:RPN2
gene id: 9541:RPN2
uniprot id: A0A2K5UST6
uniprot id: A0A2K5USU9
uniprot id: A0A2K5USZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9541:FXYD3
gene id: 9541:FXYD3
uniprot id: A0A2K5WBR5
names: Similarity
messages: Belongs to the FXYD family.

9541:S100A6
gene id: 9541:S100A6
uniprot id: A0A2K5V4Q2
uniprot id: G7NUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9541:LDHAL6B
gene id: 9541:LDHAL6B
uniprot id: Q4R816
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9541:UBE2T
gene id: 9541:UBE2T
uniprot id: A0A2K5U653
uniprot id: G7NWE1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:NAPA
gene id: 9541:NAPA
uniprot id: I7GH32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9541:CEP295
gene id: 9541:CEP295
uniprot id: A0A2K5WUG6
names: Subcellular Location Annotation
messages: centrosome

9541:OTUD7B
gene id: 9541:OTUD7B
uniprot id: A0A2K5TTA1
uniprot id: G7NTS2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:CCDC167
gene id: 9541:CCDC167
uniprot id: A0A2K5UV61
uniprot id: G7P3D4
names: Subcellular Location Annotation
messages: Membrane

9541:GRK7
gene id: 9541:GRK7
uniprot id: A0A2K5TV47
uniprot id: G7P015
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:ZER1
gene id: 9541:ZER1
uniprot id: A0A8J8XPV2
uniprot id: G7PRE8
names: Similarity
messages: Belongs to the zyg-11 family.

9541:LOC107129596
gene id: 9541:LOC107129596
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:GLO1
gene id: 9541:GLO1
uniprot id: G7P3D8
uniprot id: Q4R5F2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (By similarity). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (By similarity).
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
messages: Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity).
messages: Glutathionylation at Cys-139 inhibits enzyme activity.
messages: Homodimer.
messages: Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity).

9541:ZNF215
gene id: 9541:ZNF215
uniprot id: A0A2K5WTN4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102117046
gene id: 9541:LOC102117046
uniprot id: A0A2K5UUJ1
uniprot id: I7GA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9541:SIDT1
gene id: 9541:SIDT1
uniprot id: A0A2K5UUN3
uniprot id: A0A2K5UUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9541:EPHB3
gene id: 9541:EPHB3
uniprot id: A0A2K5W4F3
uniprot id: A0A2K5W4J4
names: Subcellular Location Annotation
messages: Membrane

9541:ACP7
gene id: 9541:ACP7
uniprot id: A0A2K5WEP7
uniprot id: A0A8J8XKK7
uniprot id: G7PXI5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9541:SLX1A
gene id: 9541:SLX1A
uniprot id: A0A2K5TXK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Belongs to the sulfotransferase 1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

9541:ILF3
gene id: 9541:ILF3
uniprot id: A0A2K5X6D2
uniprot id: A0A2K5X6D6
uniprot id: A0A2K5X712
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:RAB8A
gene id: 9541:RAB8A
uniprot id: Q4R5P1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with PIFO (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).
messages: Midbody
messages: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Recycling endosome membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).
messages: centriole
messages: cilium
messages: cilium basal body
messages: phagosome membrane

9541:COPZ2
gene id: 9541:COPZ2
uniprot id: I7GJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9541:CAMSAP1
gene id: 9541:CAMSAP1
uniprot id: A0A2K5U7Q2
uniprot id: A0A2K5U7R5
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9541:SAA4
gene id: 9541:SAA4
uniprot id: A0A2K5WKU4
uniprot id: A0A7N9IDU3
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9541:SPATA17
gene id: 9541:SPATA17
uniprot id: Q4R7Z7
names: Subcellular Location Annotation
messages: Cytoplasm

9541:WDR45
gene id: 9541:WDR45
uniprot id: A0A2K5V5Q7
uniprot id: A0A2K5V683
uniprot id: A0A2K5V6B4
uniprot id: A0A2K5V6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

9541:PRDM15
gene id: 9541:PRDM15
uniprot id: A0A2K5U2Q5
uniprot id: A0A2K5U2Q8
names: Subcellular Location Annotation
messages: Nucleus

9541:HSPA9
gene id: 9541:HSPA9
uniprot id: A0A2K5VSK5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:KRR1
gene id: 9541:KRR1
uniprot id: A0A2K5TN33
uniprot id: A0A2K5TN62
uniprot id: G7PI30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9541:SLC17A1
gene id: 9541:SLC17A1
uniprot id: G7P2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9541:UGCG
gene id: 9541:UGCG
uniprot id: A0A2K5WQV5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9541:PTH
gene id: 9541:PTH
uniprot id: G7PQP2
uniprot id: Q9XT35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9541:LLGL1
gene id: 9541:LLGL1
uniprot id: A0A2K5U6E0
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9541:SLC16A14
gene id: 9541:SLC16A14
uniprot id: A0A2K5WN05
names: Subcellular Location Annotation
messages: Membrane

9541:EXOC6B
gene id: 9541:EXOC6B
uniprot id: A0A2K5V5C6
uniprot id: A0A2K5V5E9
uniprot id: A0A7N9CB83
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:LOC101865054
gene id: 9541:LOC101865054
uniprot id: A0A2K5VPJ1
uniprot id: I7GPL8
names: Similarity
messages: Belongs to the PHYHIP family.

9541:RSBN1
gene id: 9541:RSBN1
uniprot id: A0A2K5X9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9541:DKK4
gene id: 9541:DKK4
uniprot id: A0A2K5TRM2
uniprot id: G7PBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9541:AATF
gene id: 9541:AATF
uniprot id: I7GNX0
names: Similarity
messages: Belongs to the AATF family.

9541:DNAJC9
gene id: 9541:DNAJC9
uniprot id: G7PF15
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9541:PEBP4
gene id: 9541:PEBP4
uniprot id: A0A2K5X0P4
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9541:CENPU
gene id: 9541:CENPU
uniprot id: A0A2K5VF40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9541:ECHDC2
gene id: 9541:ECHDC2
uniprot id: A0A2K5W0C9
uniprot id: G7NVP7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:PDS5A
gene id: 9541:PDS5A
uniprot id: A0A2K5VEZ2
names: Similarity
messages: Belongs to the PDS5 family.

9541:PER1
gene id: 9541:PER1
uniprot id: A0A2K5VK29
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:AACS
gene id: 9541:AACS
uniprot id: Q9N0E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).
messages: cytosol

9541:TFDP3
gene id: 9541:TFDP3
uniprot id: A0A2K5US80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:LUM
gene id: 9541:LUM
uniprot id: Q4R4R3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9541:LSM14A
gene id: 9541:LSM14A
uniprot id: A0A2K5UDB2
uniprot id: A0A2K5UDC8
names: Similarity
messages: Belongs to the LSM14 family.

9541:CYP4V2
gene id: 9541:CYP4V2
uniprot id: A0A2K5U594
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:TAC1
gene id: 9541:TAC1
uniprot id: A0A2K5X6I4
uniprot id: A0A2K5X6K8
uniprot id: Q2PFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9541:UGP2
gene id: 9541:UGP2
uniprot id: A0A2K5VC98
uniprot id: A0A2K5VCA2
uniprot id: A0A2K5VCC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9541:ASF1B
gene id: 9541:ASF1B
uniprot id: A0A2K5VLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9541:GPR157
gene id: 9541:GPR157
uniprot id: A0A2K5TW36
names: Subcellular Location Annotation
messages: Membrane

9541:RGS14
gene id: 9541:RGS14
uniprot id: A0A2K5WNN0
names: Subcellular Location Annotation
messages: dendrite

9541:SPIN1
gene id: 9541:SPIN1
uniprot id: A0A2K5U068
uniprot id: A0A8J8XDI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9541:N4BP3
gene id: 9541:N4BP3
uniprot id: A0A2K5WDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9541:RPS7
gene id: 9541:RPS7
uniprot id: A0A2K5W178
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9541:DIPK2A
gene id: 9541:DIPK2A
uniprot id: A0A2K5TMH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9541:APOM
gene id: 9541:APOM
uniprot id: A0A2K5VDN5
uniprot id: G7P4P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9541:TBX22
gene id: 9541:TBX22
uniprot id: A0A8J8XP92
uniprot id: G7Q341
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:IDH2
gene id: 9541:IDH2
uniprot id: Q4R502
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3 (By similarity).
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity).

9541:TOMM40
gene id: 9541:TOMM40
uniprot id: A0A2K5TZM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:CLK4
gene id: 9541:CLK4
uniprot id: A0A2K5X0K8
uniprot id: A0A2K5X114
uniprot id: A0A7N9CE55
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SRD5A2
gene id: 9541:SRD5A2
uniprot id: Q28892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:NT5C3A
gene id: 9541:NT5C3A
uniprot id: A0A2K5WTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9541:CLTB
gene id: 9541:CLTB
uniprot id: A0A2K5TU49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9541:CD63
gene id: 9541:CD63
uniprot id: A0A2K5TKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9541:FRZB
gene id: 9541:FRZB
uniprot id: A0A2K5V9H7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9541:CCDC142
gene id: 9541:CCDC142
uniprot id: G7PMJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9541:MDH1B
gene id: 9541:MDH1B
uniprot id: A0A2K5VAL2
uniprot id: A0A7N9CNW0
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9541:CDK5
gene id: 9541:CDK5
uniprot id: A0A2K5TYL9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TFPI
gene id: 9541:TFPI
uniprot id: A0A2K5UGS2
uniprot id: Q2PFV4
names: Subcellular Location Annotation
messages: Secreted

9541:WDFY2
gene id: 9541:WDFY2
uniprot id: A0A2K5W0S0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9541:PLA1A
gene id: 9541:PLA1A
uniprot id: A0A2K5VMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:NINJ1
gene id: 9541:NINJ1
uniprot id: A0A2K5WWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9541:LOC102121923
gene id: 9541:LOC102121923
uniprot id: A0A7N9D2F1
names: Similarity
messages: Belongs to the MS4A family.

9541:EBAG9
gene id: 9541:EBAG9
uniprot id: A0A2K5UB51
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9541:ADHFE1
gene id: 9541:ADHFE1
uniprot id: A0A2K5ULA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9541:PGM1
gene id: 9541:PGM1
uniprot id: A0A2K5TVT5
uniprot id: Q4R5E4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.
messages: This enzyme participates in both the breakdown and synthesis of glucose.

9541:TRAPPC2L
gene id: 9541:TRAPPC2L
uniprot id: A0A2K5W9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9541:LOC102137744
gene id: 9541:LOC102137744
uniprot id: A0A8J8XQP4
uniprot id: G7P2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:DGLUCY
gene id: 9541:DGLUCY
uniprot id: A0A2K5UUX8
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9541:LOC102136165
gene id: 9541:LOC102136165
uniprot id: A0A2K5X3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9541:LRP6
gene id: 9541:LRP6
uniprot id: A0A2K5VCG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PLSCR5
gene id: 9541:PLSCR5
uniprot id: A0A2K5UUH6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9541:TIMP1
gene id: 9541:TIMP1
uniprot id: A0A2K5WNU0
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9541:CHMP4B
gene id: 9541:CHMP4B
uniprot id: A0A2K5WZD2
names: Similarity
messages: Belongs to the SNF7 family.

9541:CYSLTR2
gene id: 9541:CYSLTR2
uniprot id: A0A7N9CNM6
uniprot id: G7PVE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:PSEN1
gene id: 9541:PSEN1
uniprot id: A0A8J8XDD5
uniprot id: G7PAT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9541:KEG98 p08
gene id: 9541:KEG98_p08
uniprot id: C3W4Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9541:VAMP2
gene id: 9541:VAMP2
uniprot id: I7GCX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

9541:DEFB132
gene id: 9541:DEFB132
uniprot id: A4H265
uniprot id: G7PGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:CHRNE
gene id: 9541:CHRNE
uniprot id: A0A2K5UB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:HOOK1
gene id: 9541:HOOK1
uniprot id: A0A2K5UAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9541:CRY1
gene id: 9541:CRY1
uniprot id: A0A8J8XQ28
uniprot id: G7PI44
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9541:TNNT2
gene id: 9541:TNNT2
uniprot id: A0A2K5WBC9
uniprot id: A0A2K5WBM2
uniprot id: A0A2K5WBM8
uniprot id: A0A2K5WBT9
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9541:PUS3
gene id: 9541:PUS3
uniprot id: A0A2K5TSS2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9541:SERPINA11
gene id: 9541:SERPINA11
uniprot id: A0A2K5VTE5
names: Similarity
messages: Belongs to the serpin family.

9541:UBE2G1
gene id: 9541:UBE2G1
uniprot id: Q4R5Y8
names: Function
names: PTM
names: Similarity
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.
messages: Autoubiquitinated.
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:LOC102135406
gene id: 9541:LOC102135406
uniprot id: A0A2K5VQK1
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9541:SNX31
gene id: 9541:SNX31
uniprot id: A0A2K5U622
names: Similarity
messages: Belongs to the sorting nexin family.

9541:LOC102144088
gene id: 9541:LOC102144088
uniprot id: A0A7N9CH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:POLR2B
gene id: 9541:POLR2B
uniprot id: A0A2K5VZA8
uniprot id: G7P5R6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9541:SDR42E1
gene id: 9541:SDR42E1
uniprot id: G7PZU6
uniprot id: Q4R7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-beta-HSD family.
messages: Membrane

9541:KRT79
gene id: 9541:KRT79
uniprot id: A0A2K5UDL3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:OSBPL10
gene id: 9541:OSBPL10
uniprot id: A0A2K5WRP9
uniprot id: A0A2K5WRR9
names: Similarity
messages: Belongs to the OSBP family.

9541:CD38
gene id: 9541:CD38
uniprot id: G7P5B0
uniprot id: Q5VAN0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP inhibits the hydrolyzing activity.
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane
messages: Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system (By similarity).

9541:PSMA3
gene id: 9541:PSMA3
uniprot id: A0A2K5W6A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:ADM
gene id: 9541:ADM
uniprot id: A0A2K5TTY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9541:CHORDC1
gene id: 9541:CHORDC1
uniprot id: Q4R7U2
names: Function
names: Subunit
messages: Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.
messages: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity).

9541:ABAT
gene id: 9541:ABAT
uniprot id: A0A2K5UZZ0
uniprot id: G7Q0G5
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9541:CA12
gene id: 9541:CA12
uniprot id: A0A2K5TSA5
uniprot id: A0A2K5TSB2
uniprot id: A0A2K5TSC4
uniprot id: A0A7N9IEH5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:ORC6
gene id: 9541:ORC6
uniprot id: A0A2K5UCL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9541:PCK1
gene id: 9541:PCK1
uniprot id: A0A2K5VHT3
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9541:MS4A3
gene id: 9541:MS4A3
uniprot id: A0A2K5WXS6
uniprot id: G7PQ10
names: Similarity
messages: Belongs to the MS4A family.

9541:NIBAN1
gene id: 9541:NIBAN1
uniprot id: A0A2K5TPU1
names: Similarity
messages: Belongs to the Niban family.

9541:IFNAR1
gene id: 9541:IFNAR1
uniprot id: A0A2K5VGY1
uniprot id: A0A7N9D7J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9541:AMIGO3
gene id: 9541:AMIGO3
uniprot id: A0A2K5UMB3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9541:IGFBP2
gene id: 9541:IGFBP2
uniprot id: A0A2K5WZA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RGS3
gene id: 9541:RGS3
uniprot id: A0A2K5WTX1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:VPS13B
gene id: 9541:VPS13B
uniprot id: A0A2K5WHQ8
uniprot id: A0A2K5WHZ8
names: Similarity
messages: Belongs to the VPS13 family.

9541:FGR
gene id: 9541:FGR
uniprot id: A0A2K5WJL3
uniprot id: A0A7N9CQJ0
uniprot id: G7NWU6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:POLD2
gene id: 9541:POLD2
uniprot id: A0A2K5W0C6
uniprot id: A0A8J8YHG8
uniprot id: Q4R5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9541:FUBP1
gene id: 9541:FUBP1
uniprot id: A0A2K5V069
uniprot id: A0A7N9D6Y9
names: Subcellular Location Annotation
messages: Nucleus

9541:EI24
gene id: 9541:EI24
uniprot id: A0A2K5VD06
uniprot id: A0A2K5VD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9541:MRPS11
gene id: 9541:MRPS11
uniprot id: I7GJD7
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9541:SLC15A2
gene id: 9541:SLC15A2
uniprot id: A0A2K5V056
uniprot id: G7NXR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9541:LOC102120872
gene id: 9541:LOC102120872
uniprot id: A0A2K5WIV2
names: Similarity
messages: Belongs to the intermediate filament family.

9541:USB1
gene id: 9541:USB1
uniprot id: A0A2K5WCV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9541:CDCA7L
gene id: 9541:CDCA7L
uniprot id: A0A2K5TT79
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:DNASE1L3
gene id: 9541:DNASE1L3
uniprot id: A0A2K5VYE2
uniprot id: G7NZC1
names: Similarity
messages: Belongs to the DNase I family.

9541:STK40
gene id: 9541:STK40
uniprot id: I7GC38
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9541:LOC102128567
gene id: 9541:LOC102128567
uniprot id: A0A2K5UJM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TAF15
gene id: 9541:TAF15
uniprot id: A0A2K5VXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9541:PGLYRP4
gene id: 9541:PGLYRP4
uniprot id: A0A2K5W6T5
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9541:LOC107126377
gene id: 9541:LOC107126377
uniprot id: A0A8U0WQ25
uniprot id: G8F3V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:TSPAN7
gene id: 9541:TSPAN7
uniprot id: Q4R5A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:NDUFB6
gene id: 9541:NDUFB6
uniprot id: A0A2K5VNL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:ZDHHC24
gene id: 9541:ZDHHC24
uniprot id: A0A2K5U6Y0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:LOC102133217
gene id: 9541:LOC102133217
uniprot id: A0A2K5W9Q7
names: Similarity
messages: Belongs to the intermediate filament family.

9541:CFAP300
gene id: 9541:CFAP300
uniprot id: A0A2K5WC47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9541:RPLP0
gene id: 9541:RPLP0
uniprot id: I7GJL8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9541:LANCL1
gene id: 9541:LANCL1
uniprot id: A0A2K5VVY4
uniprot id: A0A2K5VWA1
uniprot id: G7PLC1
names: Similarity
messages: Belongs to the LanC-like protein family.

9541:UNC45A
gene id: 9541:UNC45A
uniprot id: A0A2K5W2E7
uniprot id: G7P9H1
names: Subcellular Location Annotation
messages: perinuclear region

9541:SULT1B1
gene id: 9541:SULT1B1
uniprot id: A0A2K5VZW5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:STRA6
gene id: 9541:STRA6
uniprot id: A0A2K5TNK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:CYP3A7
gene id: 9541:CYP3A7
uniprot id: B1Q2L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:CYP2C19
gene id: 9541:CYP2C19
uniprot id: Q0HA19
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:ZPR1
gene id: 9541:ZPR1
uniprot id: A0A2K5UQF6
names: Similarity
messages: Belongs to the ZPR1 family.

9541:CELF3
gene id: 9541:CELF3
uniprot id: A0A2K5X0L7
uniprot id: A0A2K5X0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9541:ALDH3A2
gene id: 9541:ALDH3A2
uniprot id: A0A2K5UZN9
uniprot id: A0A2K5UZP3
uniprot id: Q60HH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Microsome membrane

9541:C14H11orf68
gene id: 9541:C14H11orf68
uniprot id: A0A2K5V960
names: Similarity
messages: Belongs to the UPF0696 family.

9541:MAST1
gene id: 9541:MAST1
uniprot id: A0A2K5WUP4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9541:ATP9B
gene id: 9541:ATP9B
uniprot id: A0A2K5VBT6
uniprot id: A0A2K5VBZ6
uniprot id: A0A2K5VC06
uniprot id: A0A7N9CZH0
uniprot id: A0A7N9D7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9541:PRR15L
gene id: 9541:PRR15L
uniprot id: A0A2K5UP02
uniprot id: G8F625
names: Similarity
messages: Belongs to the PRR15 family.

9541:PLPP1
gene id: 9541:PLPP1
uniprot id: A0A2K5UR95
uniprot id: A0A2K5URB3
uniprot id: A0A7N9IE10
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9541:CALHM4
gene id: 9541:CALHM4
uniprot id: A0A2K5V7J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:GPR132
gene id: 9541:GPR132
uniprot id: A0A2K5VAF1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:RBBP7
gene id: 9541:RBBP7
uniprot id: A0A8J8Y4H5
uniprot id: G7Q2B1
uniprot id: Q4R304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1; BPTF; RBBP4 and RBBP7 (By similarity). Within the complex interacts with SMARCA1 (By similarity). Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with CENPA. Interacts with BRCA1, HDAC7 and SUV39H1 (By similarity). Interacts with PWWP2B (By similarity).
messages: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
messages: Nucleus

9541:SNAPIN
gene id: 9541:SNAPIN
uniprot id: A0A2K5W620
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9541:EIF4G3
gene id: 9541:EIF4G3
uniprot id: A0A2K5VA69
uniprot id: A0A2K5VA93
uniprot id: A0A2K5VAD7
uniprot id: A0A2K5VAF8
uniprot id: A0A7N9DBY5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9541:ERCC5
gene id: 9541:ERCC5
uniprot id: A0A2K5TZM7
names: Subcellular Location Annotation
messages: Nucleus

9541:TM4SF20
gene id: 9541:TM4SF20
uniprot id: A0A2K5WG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9541:PLXNB1
gene id: 9541:PLXNB1
uniprot id: A0A2K5VBD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:KCTD6
gene id: 9541:KCTD6
uniprot id: A0A8J8YEU1
uniprot id: G7NZB5
names: Subcellular Location Annotation
messages: Cell membrane

9541:PRM1
gene id: 9541:PRM1
uniprot id: A0A8J8XIC9
uniprot id: G7Q0H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9541:DIP2A
gene id: 9541:DIP2A
uniprot id: A0A2K5WH50
names: Similarity
messages: Belongs to the DIP2 family.

9541:NUP62
gene id: 9541:NUP62
uniprot id: Q4R513
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9541:SRPX2
gene id: 9541:SRPX2
uniprot id: A0A2K5VS42
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9541:CUTC
gene id: 9541:CUTC
uniprot id: A0A8J8XRE7
uniprot id: G7PDQ4
names: Similarity
messages: Belongs to the CutC family.

9541:AVPI1
gene id: 9541:AVPI1
uniprot id: A0A2K5VGI2
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9541:POFUT1
gene id: 9541:POFUT1
uniprot id: A0A2K5WTE3
uniprot id: I7GHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9541:RPS27L
gene id: 9541:RPS27L
uniprot id: A0A2K5X425
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9541:MED17
gene id: 9541:MED17
uniprot id: I7GJG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:TM2D3
gene id: 9541:TM2D3
uniprot id: A0A2K5UII3
uniprot id: A0A2K5UIJ1
names: Subcellular Location Annotation
messages: Membrane

9541:HIPK4
gene id: 9541:HIPK4
uniprot id: Q8WP28
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
messages: Cytoplasm
messages: Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).

9541:CBLL2
gene id: 9541:CBLL2
uniprot id: Q4R361
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.
messages: Homodimer.
messages: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.

9541:POLA1
gene id: 9541:POLA1
uniprot id: A0A2K5TTK6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9541:CCDC89
gene id: 9541:CCDC89
uniprot id: Q95JI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC89 family.
messages: Cytoplasm
messages: Interacts with HEY1.
messages: Nucleus

9541:LOC101926570
gene id: 9541:LOC101926570
uniprot id: I7GEY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9541:IL36RN
gene id: 9541:IL36RN
uniprot id: A0A2K5UWR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:TSPO
gene id: 9541:TSPO
uniprot id: A0A2K5TLZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane
messages: Mitochondrion membrane

9541:NUBPL
gene id: 9541:NUBPL
uniprot id: A0A8J8XZC4
uniprot id: G7PA18
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9541:CPSF2
gene id: 9541:CPSF2
uniprot id: A0A8J8YIL5
uniprot id: G7PBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9541:LOC102137613
gene id: 9541:LOC102137613
uniprot id: A0A2K5W7T7
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.

9541:DRC7
gene id: 9541:DRC7
uniprot id: A0A2K5WM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9541:MYF6
gene id: 9541:MYF6
uniprot id: A0A8J8YFV7
uniprot id: G7PIK1
names: Subcellular Location Annotation
messages: Nucleus

9541:AK1
gene id: 9541:AK1
uniprot id: A0A2K5V0D6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9541:GDI1
gene id: 9541:GDI1
uniprot id: A0A158SIP6
uniprot id: Q8HXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.
messages: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By similarity).
messages: trans-Golgi network

9541:SLC46A2
gene id: 9541:SLC46A2
uniprot id: A0A2K5VFE1
names: Subcellular Location Annotation
messages: Membrane

9541:SLC6A12
gene id: 9541:SLC6A12
uniprot id: A0A2K5VNR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

9541:EFEMP1
gene id: 9541:EFEMP1
uniprot id: Q7YQD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity).
messages: Interacts with ECM1. Interacts with TIMP3.
messages: extracellular matrix
messages: extracellular space

9541:CXCL11
gene id: 9541:CXCL11
uniprot id: A0A8J8XWC3
uniprot id: G7P556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:DCK
gene id: 9541:DCK
uniprot id: Q4R5R5
names: Similarity
messages: Belongs to the DCK/DGK family.

9541:RPL30
gene id: 9541:RPL30
uniprot id: A0A158SIP2
uniprot id: Q76KA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:SLCO6A1
gene id: 9541:SLCO6A1
uniprot id: A0A2K5WXZ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SURF4
gene id: 9541:SURF4
uniprot id: A0A2K5VTP9
uniprot id: A0A7N9CUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

9541:POLH
gene id: 9541:POLH
uniprot id: A0A2K5VUR0
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM174A
gene id: 9541:FAM174A
uniprot id: A0A2K5V3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:LOC102131133
gene id: 9541:LOC102131133
uniprot id: A0A2K5WE79
uniprot id: G7P6C8
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FAM161A
gene id: 9541:FAM161A
uniprot id: A0A2K5ULS5
uniprot id: A0A2K5ULT2
names: Similarity
messages: Belongs to the FAM161 family.

9541:MBOAT4
gene id: 9541:MBOAT4
uniprot id: A0A2K5WY55
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102127963
gene id: 9541:LOC102127963
uniprot id: A0A2K5UIM1
uniprot id: G7PUR5
names: Similarity
messages: Belongs to the intermediate filament family.

9541:DHX58
gene id: 9541:DHX58
uniprot id: A0A2K5WGV9
uniprot id: A0A2K5WGW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9541:MAP2K3
gene id: 9541:MAP2K3
uniprot id: A0A2K5WJP6
uniprot id: A0A2K5WJZ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:MRPL3
gene id: 9541:MRPL3
uniprot id: G7NXZ9
uniprot id: I7GKE3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9541:LOC102128939
gene id: 9541:LOC102128939
uniprot id: A0A2K5UDX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:RPL21
gene id: 9541:RPL21
uniprot id: A0A2K5UG77
uniprot id: G7PVW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:MNDA
gene id: 9541:MNDA
uniprot id: Q8SPH9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
messages: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1 (By similarity).
messages: Nucleus
messages: Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23 (By similarity).

9541:APAF1
gene id: 9541:APAF1
uniprot id: A0A2K5X3C3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9541:LHFPL6
gene id: 9541:LHFPL6
uniprot id: I7GNY1
names: Subcellular Location Annotation
messages: Membrane

9541:ACTRT2
gene id: 9541:ACTRT2
uniprot id: Q4R317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9541:NCBP3
gene id: 9541:NCBP3
uniprot id: A0A2K5UJ59
names: Similarity
messages: Belongs to the NCBP3 family.

9541:GSTM2
gene id: 9541:GSTM2
uniprot id: Q9TSM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (By similarity). Has activity toward aflatoxin B(1)-8,9-epoxide (AFBO) (PubMed:10869451).
messages: Cytoplasm
messages: Homodimer.

9541:CASP6
gene id: 9541:CASP6
uniprot id: G7P629
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9541:LOC102126517
gene id: 9541:LOC102126517
uniprot id: A0A7N9D902
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9541:CHST9
gene id: 9541:CHST9
uniprot id: A0A2K5WJL9
uniprot id: A0A8J8YFQ8
uniprot id: G7PWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:XG
gene id: 9541:XG
uniprot id: A0A2K5UP34
names: Similarity
messages: Belongs to the CD99 family.

9541:POLR1B
gene id: 9541:POLR1B
uniprot id: A0A2K5V5H3
uniprot id: G7PMZ1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9541:DEFA6
gene id: 9541:DEFA6
uniprot id: A0A8J8YGN9
uniprot id: G7PCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:HDDC2
gene id: 9541:HDDC2
uniprot id: A0A2K5UAF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9541:IL2RA
gene id: 9541:IL2RA
uniprot id: H6WS54
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9541:MOB3C
gene id: 9541:MOB3C
uniprot id: A0A2K5UZ90
uniprot id: G7NVL8
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:EIF3M
gene id: 9541:EIF3M
uniprot id: A0A2K5TRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9541:B4GALT6
gene id: 9541:B4GALT6
uniprot id: A0A2K5V5Q0
uniprot id: A0A2K5V5W8
uniprot id: A0A2K5V5Z4
uniprot id: A0A8J8Y1F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:FAAH2
gene id: 9541:FAAH2
uniprot id: A0A8J8YRN5
uniprot id: G7Q2V7
names: Similarity
messages: Belongs to the amidase family.

9541:STOML2
gene id: 9541:STOML2
uniprot id: G7PS14
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9541:MCHR1
gene id: 9541:MCHR1
uniprot id: A0A2K5VT41
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9541:TFB1M
gene id: 9541:TFB1M
uniprot id: A0A8J8Y2R5
uniprot id: G7P4X1
uniprot id: Q2PG46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity).
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9541:CDH5
gene id: 9541:CDH5
uniprot id: A0A2K5TSK2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9541:ARMC1
gene id: 9541:ARMC1
uniprot id: A0A8J8XP95
uniprot id: G7PBX8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9541:ING1
gene id: 9541:ING1
uniprot id: A0A2K5VJB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:SMAD4
gene id: 9541:SMAD4
uniprot id: A0A8J8XZF7
uniprot id: G7PWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9541:ALG5
gene id: 9541:ALG5
uniprot id: A0A8J8YEI8
uniprot id: G7PW14
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9541:YIPF5
gene id: 9541:YIPF5
uniprot id: I7GM50
uniprot id: Q4R5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: COPII-coated vesicle
messages: Endoplasmic reticulum membrane
messages: Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts with YIF1A (By similarity). May interact with RAB1A (By similarity). Interacts with YIPF3 and YIPF4 (By similarity).
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.
messages: cis-Golgi network membrane

9541:RNASE7
gene id: 9541:RNASE7
uniprot id: A0A7N9D1I0
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:LEPROT
gene id: 9541:LEPROT
uniprot id: A0A2K5TJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9541:ATP23
gene id: 9541:ATP23
uniprot id: A0A2K5UXC9
names: Similarity
messages: Belongs to the peptidase M76 family.

9541:AGTPBP1
gene id: 9541:AGTPBP1
uniprot id: A0A2K5X501
uniprot id: G7PSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9541:APLP1
gene id: 9541:APLP1
uniprot id: A0A2K5WNL8
uniprot id: Q4R4M8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NNT
gene id: 9541:NNT
uniprot id: A0A2K5WQE6
uniprot id: G7P7G8
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9541:LOC102121007
gene id: 9541:LOC102121007
uniprot id: A0A2K5V5R5
uniprot id: Q4R791
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:FOXN1
gene id: 9541:FOXN1
uniprot id: A0A2K5VVX4
names: Subcellular Location Annotation
messages: Nucleus

9541:TNMD
gene id: 9541:TNMD
uniprot id: A0A8J8YP78
uniprot id: G7Q376
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9541:DGUOK
gene id: 9541:DGUOK
uniprot id: A0A2K5VPR5
uniprot id: A0A8J8Y974
uniprot id: G7PMI3
names: Similarity
messages: Belongs to the DCK/DGK family.

9541:ATP13A5
gene id: 9541:ATP13A5
uniprot id: A0A2K5WEC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NPRL2
gene id: 9541:NPRL2
uniprot id: A0A8J8XVQ8
uniprot id: G7NXS3
names: Similarity
messages: Belongs to the NPR2 family.

9541:KIF6
gene id: 9541:KIF6
uniprot id: A0A2K5X048
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:SPAG7
gene id: 9541:SPAG7
uniprot id: I7G600
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102129319
gene id: 9541:LOC102129319
uniprot id: A0A2K5UE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:FNIP2
gene id: 9541:FNIP2
uniprot id: A0A2K5U626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9541:HMGN2
gene id: 9541:HMGN2
uniprot id: A0A8J8YAJ5
uniprot id: G7NXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:CNOT2
gene id: 9541:CNOT2
uniprot id: A0A2K5WHU3
uniprot id: A0A2K5WI09
uniprot id: A0A8J8XFT7
uniprot id: G7PI14
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9541:PLA2G4F
gene id: 9541:PLA2G4F
uniprot id: A0A2K5WML9
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9541:SCD5
gene id: 9541:SCD5
uniprot id: A0A2K5W2B7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9541:MAGI3
gene id: 9541:MAGI3
uniprot id: A0A2K5X0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9541:EIF4A3
gene id: 9541:EIF4A3
uniprot id: Q4R3Q1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro). Interacts with NCBP3 (By similarity). Interacts with NRDE2 (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The ATPase activity is increased some 4-fold in the presence of RNA.

9541:NRDE2
gene id: 9541:NRDE2
uniprot id: A0A2K5UAL1
names: Similarity
messages: Belongs to the NRDE2 family.

9541:TOR2A
gene id: 9541:TOR2A
uniprot id: A0A2K5VHH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9541:LIPG
gene id: 9541:LIPG
uniprot id: A0A2K5TPF3
uniprot id: G8F3E1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:TOR1A
gene id: 9541:TOR1A
uniprot id: Q60HG2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane (By similarity).
messages: N-glycosylated.
messages: Nucleus membrane
messages: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity).
messages: cytoskeleton
messages: growth cone
messages: secretory vesicle
messages: synaptic vesicle

9541:SPDYA
gene id: 9541:SPDYA
uniprot id: A0A7N9CX77
uniprot id: A0A8J8YGP1
uniprot id: G7PLY1
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9541:MELK
gene id: 9541:MELK
uniprot id: A0A2K5X6B1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9541:MFAP1
gene id: 9541:MFAP1
uniprot id: A0A8J8XU30
uniprot id: Q4R7A1
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9541:GMDS
gene id: 9541:GMDS
uniprot id: I7GL28
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9541:XRN1
gene id: 9541:XRN1
uniprot id: A0A2K5V3C7
uniprot id: A0A2K5V3D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9541:CNOT1
gene id: 9541:CNOT1
uniprot id: A0A2K5VB84
uniprot id: A0A2K5VBD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9541:ITGB1
gene id: 9541:ITGB1
uniprot id: A0A2K5WHU8
uniprot id: A0A2K5WHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9541:NCOA2
gene id: 9541:NCOA2
uniprot id: A0A2K5UID3
uniprot id: A0A2K5UIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9541:HYPK
gene id: 9541:HYPK
uniprot id: Q2PFU1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of several N-terminal acetyltransferase complexes (By similarity). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (By similarity). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (By similarity). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (By similarity).
messages: Component of the N-terminal acetyltransferase A (NatA)/HYPK complex at least composed of NAA10, NAA15 and HYPK, which has N-terminal acetyltransferase activity (By similarity). Within the complex interacts with NAA10 (By similarity). Within the complex interacts with NAA15 (By similarity). Predominantly interacts with NAA15 in the NAA10-NAA15 complex (also called the NatA complex); the interaction with the NatA complex reduces the acetylation activity of the NatA complex (By similarity). Interacts with HTT (via N-terminus) (By similarity). The NatA complex is required for HYPK stability and for reducing polyQ aggregation of HTT (By similarity). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (By similarity). Within the complex interacts with NAA10 and NAA15 (By similarity). Does not interact with NAA50 (By similarity). Interaction with NAA15 reduces the capacity of NAA15 to interact with NAA50 (By similarity). Its capacity to interact with the NatA complex is reduced by NAA50 (By similarity). Does not interact with the N-terminal acetyltransferase B (NatB) complex component NAA25 or the N-terminal acetyltransferase C (NatC) complex component NAA35 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex, however it is unclear if it acts as an activator or inhibitor of the complex (By similarity). Has been shown in one study to be required for efficient N-terminal acetylation of NAA10-NAA15 complex substrates in vivo and in vitro (By similarity). Another study, however, has shown that it acts in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

9541:L1CAM
gene id: 9541:L1CAM
uniprot id: A0A2K5UR40
uniprot id: A0A2K5UR71
uniprot id: A0A2K5URA1
uniprot id: A0A2K5URB5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9541:KRTCAP2
gene id: 9541:KRTCAP2
uniprot id: A0A2K5WII0
uniprot id: G8F698
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9541:MGAT4D
gene id: 9541:MGAT4D
uniprot id: A0A2K5W3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:GSG1L2
gene id: 9541:GSG1L2
uniprot id: A0A2K5WMR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9541:DDAH1
gene id: 9541:DDAH1
uniprot id: A0A2K5TPG8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9541:CCL20
gene id: 9541:CCL20
uniprot id: A0A2K5VMB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:CYP4A11
gene id: 9541:CYP4A11
uniprot id: A8CBR2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:LOC102125097
gene id: 9541:LOC102125097
uniprot id: A0A2K5WJG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:SLC39A9
gene id: 9541:SLC39A9
uniprot id: A0A2K5URI7
uniprot id: A0A2K5URK1
uniprot id: A0A8J8XNJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9541:L3MBTL3
gene id: 9541:L3MBTL3
uniprot id: A0A2K5TJT6
uniprot id: A0A2K5TJX0
names: Subcellular Location Annotation
messages: Nucleus

9541:MFN2
gene id: 9541:MFN2
uniprot id: A0A2K5VRH2
uniprot id: A0A8J8YMS9
uniprot id: G7NU65
uniprot id: Q4R5A0
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9541:RAF1
gene id: 9541:RAF1
uniprot id: A0A2K5WKH0
uniprot id: A0A2K5WKV3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9541:LOC102146388
gene id: 9541:LOC102146388
uniprot id: G7PZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:HIF1A
gene id: 9541:HIF1A
uniprot id: A0A2K5V188
uniprot id: Q4R658
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9541:SERPINB9
gene id: 9541:SERPINB9
uniprot id: A0A2K5VZ63
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9541:ATF4
gene id: 9541:ATF4
uniprot id: A0A2K5X782
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9541:CHEK1
gene id: 9541:CHEK1
uniprot id: A0A2K5UAE9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9541:ATP5F1D
gene id: 9541:ATP5F1D
uniprot id: A0A2K5X1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9541:LDB2
gene id: 9541:LDB2
uniprot id: A0A8J8Y9Y1
uniprot id: Q4R522
names: Similarity
messages: Belongs to the LDB family.

9541:BOLA1
gene id: 9541:BOLA1
uniprot id: G7NTR8
names: Similarity
messages: Belongs to the BolA/IbaG family.

9541:GINS2
gene id: 9541:GINS2
uniprot id: A0A2K5U021
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9541:OLFM4
gene id: 9541:OLFM4
uniprot id: A0A2K5TPK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NIPAL1
gene id: 9541:NIPAL1
uniprot id: A0A2K5WBH5
uniprot id: A0A8J8XE03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9541:USP20
gene id: 9541:USP20
uniprot id: A0A2K5TWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9541:SMIM5
gene id: 9541:SMIM5
uniprot id: A0A2K5WGL0
uniprot id: A0A7N9CHX2
names: Subcellular Location Annotation
messages: Membrane

9541:FAT4
gene id: 9541:FAT4
uniprot id: A0A2K5X9C2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:UTP11
gene id: 9541:UTP11
uniprot id: A0A8J8YJG7
uniprot id: G7NUB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9541:DDX50
gene id: 9541:DDX50
uniprot id: A0A2K5VK31
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9541:ABI1
gene id: 9541:ABI1
uniprot id: A0A2K5UYX9
uniprot id: A0A2K5UYY2
uniprot id: A0A2K5UZ16
uniprot id: A0A2K5UZ21
uniprot id: A0A2K5UZ55
uniprot id: Q2PFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9541:RACK1
gene id: 9541:RACK1
uniprot id: A0A2K5VEN4
uniprot id: Q4R7Y4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CPNE3 (By similarity). May interact with ABCB4 (By similarity). Component of the small (40S) ribosomal subunit. Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with HRAS. Interacts with LARP4B. Interacts with PKD2L1 (By similarity).
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC (By similarity).
messages: dendrite
messages: perinuclear region

9541:CRY2
gene id: 9541:CRY2
uniprot id: G7PQC1
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9541:GLB1
gene id: 9541:GLB1
uniprot id: Q60HF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
messages: Homodimer. May form higher multimers.
messages: Lysosome

9541:BICD2
gene id: 9541:BICD2
uniprot id: A0A2K5U2M3
uniprot id: A0A2K5U2M8
names: Similarity
messages: Belongs to the BicD family.

9541:TAS2R1
gene id: 9541:TAS2R1
uniprot id: A0A2K5WUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:RNASE11
gene id: 9541:RNASE11
uniprot id: G7P9L6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:BAZ2B
gene id: 9541:BAZ2B
uniprot id: A0A2K5X261
uniprot id: A0A2K5X267
names: Similarity
messages: Belongs to the WAL family.

9541:TM4SF18
gene id: 9541:TM4SF18
uniprot id: A0A7N9CA86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9541:PHKA2
gene id: 9541:PHKA2
uniprot id: A0A2K5VLC1
uniprot id: G7Q2B7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9541:SSR3
gene id: 9541:SSR3
uniprot id: I7G2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9541:LRRC8D
gene id: 9541:LRRC8D
uniprot id: A0A7N9CFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:HTR2B
gene id: 9541:HTR2B
uniprot id: A0A2K5WA17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9541:LOC102115969
gene id: 9541:LOC102115969
uniprot id: A0A8J8YAJ5
uniprot id: G7NXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:ALKBH1
gene id: 9541:ALKBH1
uniprot id: A0A2K5TU74
names: Similarity
messages: Belongs to the alkB family.

9541:YWHAZ
gene id: 9541:YWHAZ
uniprot id: A0A8J8Y9Q2
uniprot id: G7PCF6
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:NANOS3
gene id: 9541:NANOS3
uniprot id: A0A7N9CX74
names: Similarity
messages: Belongs to the nanos family.

9541:KLRF1
gene id: 9541:KLRF1
uniprot id: Q8MI05
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.
messages: Membrane

9541:RPS26
gene id: 9541:RPS26
uniprot id: P61251
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9541:BMP10
gene id: 9541:BMP10
uniprot id: A0A2K5WNW7
names: Similarity
messages: Belongs to the TGF-beta family.

9541:PTPRD
gene id: 9541:PTPRD
uniprot id: A0A2K5V162
uniprot id: A0A2K5V168
uniprot id: A0A2K5V177
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9541:FAM187B
gene id: 9541:FAM187B
uniprot id: G7PX85
uniprot id: Q4R7Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9541:SNTA1
gene id: 9541:SNTA1
uniprot id: A0A2K5X2Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9541:IRX5
gene id: 9541:IRX5
uniprot id: A0A2K5W6M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9541:PPP4R3C
gene id: 9541:PPP4R3C
uniprot id: G7Q2E9
names: Similarity
messages: Belongs to the SMEK family.

9541:PALMD
gene id: 9541:PALMD
uniprot id: A0A2K5U7C7
names: Similarity
messages: Belongs to the paralemmin family.

9541:WDR4
gene id: 9541:WDR4
uniprot id: A0A2K5WQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9541:CLTCL1
gene id: 9541:CLTCL1
uniprot id: A0A2K5V2Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9541:APOBEC3D
gene id: 9541:APOBEC3D
uniprot id: A0A2K5TZ28
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SLC35D1
gene id: 9541:SLC35D1
uniprot id: A0A2K5UJZ6
names: Subcellular Location Annotation
messages: Membrane

9541:NFXL1
gene id: 9541:NFXL1
uniprot id: A0A2K5WYX8
names: Similarity
messages: Belongs to the NFX1 family.

9541:SLCO1C1
gene id: 9541:SLCO1C1
uniprot id: A0A2K5V0W0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:GET4
gene id: 9541:GET4
uniprot id: A0A2K5U286
names: Similarity
messages: Belongs to the GET4 family.

9541:MIS18A
gene id: 9541:MIS18A
uniprot id: A0A2K5X5E4
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9541:ZNF575
gene id: 9541:ZNF575
uniprot id: Q9GM03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:GPC5
gene id: 9541:GPC5
uniprot id: A0A2K5VAP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9541:MYO5B
gene id: 9541:MYO5B
uniprot id: A0A2K5UF09
uniprot id: A0A2K5UF50
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:NDUFV2
gene id: 9541:NDUFV2
uniprot id: A0A8J8Y2C7
uniprot id: G7PWD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9541:DNMT3L
gene id: 9541:DNMT3L
uniprot id: A0A2K5WRV1
names: Subcellular Location Annotation
messages: Nucleus

9541:ADCY2
gene id: 9541:ADCY2
uniprot id: A0A2K5TV06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9541:CD163L1
gene id: 9541:CD163L1
uniprot id: A0A2K5VDF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MSX2
gene id: 9541:MSX2
uniprot id: A0A7N9D9E7
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC101925844
gene id: 9541:LOC101925844
uniprot id: Q4R4B1
names: Similarity
messages: Belongs to the STEEP1 family.

9541:NMNAT2
gene id: 9541:NMNAT2
uniprot id: A0A2K5VI95
uniprot id: G7NXG5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9541:LOC102131775
gene id: 9541:LOC102131775
uniprot id: A0A2K5WHK5
names: Similarity
messages: Belongs to the TCP11 family.

9541:ZDHHC20
gene id: 9541:ZDHHC20
uniprot id: A0A2K5VY00
uniprot id: A0A7N9IEJ6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:C6H5orf63
gene id: 9541:C6H5orf63
uniprot id: A0A2K5UEI7
names: Similarity
messages: Belongs to the glutaredoxin family.

9541:TMEM131
gene id: 9541:TMEM131
uniprot id: A0A2K5WWU9
names: Similarity
messages: Belongs to the TMEM131 family.

9541:DDX5
gene id: 9541:DDX5
uniprot id: A0A2K5ULU9
uniprot id: Q4R6G0
uniprot id: Q4R6M5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1, AR, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with NUPR1 (By similarity). Interacts with ERCC6 (By similarity). Interacts with DDX3X in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated (By similarity).
messages: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity).
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation.
messages: Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination (By similarity).
messages: Weakly phosphorylated in the G1/S phase of the cell cycle and much more at G2/M, especially at Thr and Tyr residues.
messages: nucleolus

9541:METTL6
gene id: 9541:METTL6
uniprot id: A0A2K5X8T9
uniprot id: A0A2K5X8U1
uniprot id: G7NY10
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9541:FASTKD5
gene id: 9541:FASTKD5
uniprot id: Q95KD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAST kinase family.
messages: Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
messages: Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.
messages: mitochondrion nucleoid

9541:NDUFS8
gene id: 9541:NDUFS8
uniprot id: A0A2K5U661
uniprot id: G7PP61
uniprot id: Q60HE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9541:KCNJ6
gene id: 9541:KCNJ6
uniprot id: A0A2K5X5N4
uniprot id: A0A8J8XP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9541:CACNG2
gene id: 9541:CACNG2
uniprot id: A0A2K5WFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9541:SRP54
gene id: 9541:SRP54
uniprot id: A0A8J8Y7F2
uniprot id: G7PA28
uniprot id: Q4R965
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).

9541:P2RY13
gene id: 9541:P2RY13
uniprot id: A0A2K5VG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PABIR1
gene id: 9541:PABIR1
uniprot id: Q4R310
names: Similarity
messages: Belongs to the FAM122 family.

9541:GLIS1
gene id: 9541:GLIS1
uniprot id: A0A2K5U2P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9541:BARHL1
gene id: 9541:BARHL1
uniprot id: A0A2K5U9K6
names: Subcellular Location Annotation
messages: Nucleus

9541:DHRS7B
gene id: 9541:DHRS7B
uniprot id: A0A2K5UL93
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:MACF1
gene id: 9541:MACF1
uniprot id: A0A2K5TPC0
uniprot id: A0A2K5TPC5
names: Subcellular Location Annotation
messages: cytoskeleton

9541:GJA4
gene id: 9541:GJA4
uniprot id: G7NTG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:WDR46
gene id: 9541:WDR46
uniprot id: I7G7K9
names: Subcellular Location Annotation
messages: nucleolus

9541:IL36G
gene id: 9541:IL36G
uniprot id: A0A2K5VYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:PLAUR
gene id: 9541:PLAUR
uniprot id: A0A2K5VKK1
uniprot id: A0A7N9CJE3
uniprot id: Q9GK78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity).
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
messages: Cell membrane
messages: Membrane
messages: Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
messages: invadopodium membrane

9541:GAA
gene id: 9541:GAA
uniprot id: A0A2K5VE94
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PSMF1
gene id: 9541:PSMF1
uniprot id: A0A2K5U130
uniprot id: A0A7N9CTK2
uniprot id: Q4R934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9541:HENMT1
gene id: 9541:HENMT1
uniprot id: Q4R3W5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. HEN1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

9541:TMEM94
gene id: 9541:TMEM94
uniprot id: A0A2K5W9P4
uniprot id: A0A2K5W9S0
names: Subcellular Location Annotation
messages: Membrane

9541:PSD3
gene id: 9541:PSD3
uniprot id: A0A2K5TVK4
uniprot id: A0A2K5TVK8
uniprot id: A0A2K5TVL1
names: Subcellular Location Annotation
messages: ruffle membrane

9541:PPP1R12B
gene id: 9541:PPP1R12B
uniprot id: A0A2K5WC23
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9541:TNFRSF11B
gene id: 9541:TNFRSF11B
uniprot id: A0A2K5W5R9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CLDN18
gene id: 9541:CLDN18
uniprot id: A0A2K5VVB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:NMUR1
gene id: 9541:NMUR1
uniprot id: A0A2K5WNA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9541:TAC3
gene id: 9541:TAC3
uniprot id: A0A2K5V914
uniprot id: A0A7N9CCQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9541:CHRNA5
gene id: 9541:CHRNA5
uniprot id: A0A2K5WXF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:NUP205
gene id: 9541:NUP205
uniprot id: A0A2K5WJ83
uniprot id: A0A2K5WJA6
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9541:STX1B
gene id: 9541:STX1B
uniprot id: A0A2K5V277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9541:RHOXF2
gene id: 9541:RHOXF2
uniprot id: A0A2K5V2Q9
names: Subcellular Location Annotation
messages: Nucleus

9541:CPNE4
gene id: 9541:CPNE4
uniprot id: A0A2K5UX78
uniprot id: A0A2K5UX88
uniprot id: G7NXZ8
names: Similarity
messages: Belongs to the copine family.

9541:ALDH6A1
gene id: 9541:ALDH6A1
uniprot id: A0A2K5X140
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9541:RGR
gene id: 9541:RGR
uniprot id: A0A2K5VGZ6
uniprot id: A0A7N9CQU1
names: Subcellular Location Annotation
messages: Membrane

9541:C4H6orf120
gene id: 9541:C4H6orf120
uniprot id: Q9BGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9541:NPFFR2
gene id: 9541:NPFFR2
uniprot id: A0A2K5W108
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9541:SLC39A10
gene id: 9541:SLC39A10
uniprot id: G7PL28
names: Subcellular Location Annotation
messages: Membrane

9541:IDH1
gene id: 9541:IDH1
uniprot id: A0A2K5WJA5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9541:SKA1
gene id: 9541:SKA1
uniprot id: A0A2K5TPD1
names: Similarity
messages: Belongs to the SKA1 family.

9541:NHP2
gene id: 9541:NHP2
uniprot id: A0A8J8XS32
uniprot id: G7P715
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9541:PLK2
gene id: 9541:PLK2
uniprot id: A0A2K5U903
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9541:COMTD1
gene id: 9541:COMTD1
uniprot id: I7GHH8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9541:CCL7
gene id: 9541:CCL7
uniprot id: A0A2K5UYM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:EHD1
gene id: 9541:EHD1
uniprot id: A0A2K5V3A9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9541:ZDHHC15
gene id: 9541:ZDHHC15
uniprot id: A0A2K5WVP5
uniprot id: A0A8J8XFW1
uniprot id: G7Q328
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CUL4B
gene id: 9541:CUL4B
uniprot id: A0A2K5W089
uniprot id: A0A2K5W092
uniprot id: G7Q3L8
names: Similarity
messages: Belongs to the cullin family.

9541:JAKMIP1
gene id: 9541:JAKMIP1
uniprot id: A0A2K5VCL5
uniprot id: G7P582
names: Similarity
messages: Belongs to the JAKMIP family.

9541:ASIC1
gene id: 9541:ASIC1
uniprot id: A0A2K5UB59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9541:CLDN17
gene id: 9541:CLDN17
uniprot id: A0A2K5UHT6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:MRPL28
gene id: 9541:MRPL28
uniprot id: A0A2K5UD28
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9541:ADGRF2
gene id: 9541:ADGRF2
uniprot id: A0A2K5UIP9
names: Subcellular Location Annotation
messages: Membrane

9541:PMPCB
gene id: 9541:PMPCB
uniprot id: A0A2K5TSZ1
uniprot id: Q4R5D5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9541:CSNK2B
gene id: 9541:CSNK2B
uniprot id: G7P4Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9541:LOC101865922
gene id: 9541:LOC101865922
uniprot id: A0A2K5U0B2
uniprot id: I7GLL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9541:PLSCR2
gene id: 9541:PLSCR2
uniprot id: A0A2K5VJS8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9541:CHAF1B
gene id: 9541:CHAF1B
uniprot id: A0A2K5TRB7
uniprot id: A0A8J8Y6S7
uniprot id: G7P111
names: Subcellular Location Annotation
messages: Nucleus

9541:ZNF446
gene id: 9541:ZNF446
uniprot id: A0A2K5UI12
names: Subcellular Location Annotation
messages: Nucleus

9541:GPR52
gene id: 9541:GPR52
uniprot id: G8F2R8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:PAPSS2
gene id: 9541:PAPSS2
uniprot id: A0A2K5WWP8
uniprot id: A0A2K5WWR5
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9541:SYK
gene id: 9541:SYK
uniprot id: A0A2K5V790
uniprot id: A0A2K5V796
uniprot id: G7PSP1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9541:LOC102133669
gene id: 9541:LOC102133669
uniprot id: A0A2K5W2E6
names: Similarity
messages: Belongs to the histone H2B family.

9541:SLC44A5
gene id: 9541:SLC44A5
uniprot id: A0A2K5WLA9
uniprot id: Q95JW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9541:LANCL3
gene id: 9541:LANCL3
uniprot id: A0A2K5WM40
names: Similarity
messages: Belongs to the LanC-like protein family.

9541:NRXN3
gene id: 9541:NRXN3
uniprot id: A0A2K5UVJ1
uniprot id: A0A2K5UVK9
uniprot id: A0A2K5UVT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC102132704
gene id: 9541:LOC102132704
uniprot id: A0A7N9CS21
names: Similarity
messages: Belongs to the LCE family.

9541:MLC1
gene id: 9541:MLC1
uniprot id: Q60HE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.
messages: Membrane
messages: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
messages: perinuclear region

9541:FXYD5
gene id: 9541:FXYD5
uniprot id: A0A8J8XKS7
uniprot id: G7PX84
names: Similarity
messages: Belongs to the FXYD family.

9541:RRS1
gene id: 9541:RRS1
uniprot id: A0A2K5TP91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9541:SYNE3
gene id: 9541:SYNE3
uniprot id: A0A2K5WTY2
names: Similarity
messages: Belongs to the nesprin family.

9541:TALDO1
gene id: 9541:TALDO1
uniprot id: I7G9S0
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9541:CCND3
gene id: 9541:CCND3
uniprot id: A0A2K5TJJ8
uniprot id: A0A7N9IGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9541:GSTM4
gene id: 9541:GSTM4
uniprot id: A0A023JCM9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9541:GABRA4
gene id: 9541:GABRA4
uniprot id: A0A8J8XR95
uniprot id: G7P5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:PGC
gene id: 9541:PGC
uniprot id: A0A2K5U1R3
uniprot id: A0A8J8Y3M3
uniprot id: G7P3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Secreted

9541:PDSS1
gene id: 9541:PDSS1
uniprot id: A0A2K5W1G8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:SLC17A9
gene id: 9541:SLC17A9
uniprot id: A0A2K5VMG7
names: Subcellular Location Annotation
messages: Membrane

9541:SULT4A1
gene id: 9541:SULT4A1
uniprot id: A0A2K5WIR6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:S100G
gene id: 9541:S100G
uniprot id: A0A2K5V3E4
names: Similarity
messages: Belongs to the S-100 family.

9541:DTX3L
gene id: 9541:DTX3L
uniprot id: A0A2K5UTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9541:ATP6V0E1
gene id: 9541:ATP6V0E1
uniprot id: A0A8J8XJT8
uniprot id: G7P6X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:SENP1
gene id: 9541:SENP1
uniprot id: A0A2K5TUE6
names: Similarity
messages: Belongs to the peptidase C48 family.

9541:SEC22B
gene id: 9541:SEC22B
uniprot id: A0A8J8XBA0
uniprot id: G7NX73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9541:ZC3H15
gene id: 9541:ZC3H15
uniprot id: I7GK97
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9541:TMEM132D
gene id: 9541:TMEM132D
uniprot id: A0A2K5TUJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9541:CYP19A1
gene id: 9541:CYP19A1
uniprot id: A0A8J8YF18
uniprot id: Q95LY0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:LOC102116612
gene id: 9541:LOC102116612
uniprot id: A0A2K5VUV0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9541:RNASE12
gene id: 9541:RNASE12
uniprot id: A0A2K5UIR3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:DHRS3
gene id: 9541:DHRS3
uniprot id: A0A8J8Y406
uniprot id: G7NU67
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:UBA5
gene id: 9541:UBA5
uniprot id: A0A7N9CUJ7
uniprot id: Q4R920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9541:KEG98 p03
gene id: 9541:KEG98_p03
uniprot id: C3W4Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LOC102123184
gene id: 9541:LOC102123184
uniprot id: G7P9M6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:FAM167B
gene id: 9541:FAM167B
uniprot id: A0A2K5TR07
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9541:LOC102116629
gene id: 9541:LOC102116629
uniprot id: A0A2K5WRG3
uniprot id: A0A8J8XC80
uniprot id: G7PUS6
names: Similarity
messages: Belongs to the SUI1 family.

9541:DOK5
gene id: 9541:DOK5
uniprot id: A0A2K5V0K2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9541:SDHB
gene id: 9541:SDHB
uniprot id: G7NUQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9541:S1PR3
gene id: 9541:S1PR3
uniprot id: A0A2K5UC89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:PTPN12
gene id: 9541:PTPN12
uniprot id: A0A2K5USI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9541:SPPL3
gene id: 9541:SPPL3
uniprot id: A0A2K5W4Z3
uniprot id: A0A2K5W529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9541:NR1H3
gene id: 9541:NR1H3
uniprot id: A0A2K5TX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:SIX6
gene id: 9541:SIX6
uniprot id: A0A2K5U1U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

9541:DGKA
gene id: 9541:DGKA
uniprot id: A0A8J8XJW0
uniprot id: G7PIF8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9541:MPP4
gene id: 9541:MPP4
uniprot id: A0A2K5WL68
names: Similarity
messages: Belongs to the MAGUK family.

9541:PPP1R9A
gene id: 9541:PPP1R9A
uniprot id: A0A2K5WG75
uniprot id: A0A2K5WG76
uniprot id: A0A2K5WGF1
uniprot id: A0A2K5WGF7
names: Subcellular Location Annotation
messages: cytoskeleton

9541:TCF7L1
gene id: 9541:TCF7L1
uniprot id: A0A2K5VCY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9541:RNF141
gene id: 9541:RNF141
uniprot id: A0A2K5VWB7
uniprot id: G7PQQ9
names: Function
messages: May be involved in spermatogenesis.

9541:ATG13
gene id: 9541:ATG13
uniprot id: A0A2K5TRZ8
uniprot id: A0A2K5TS06
uniprot id: A0A2K5TS08
uniprot id: A0A2K5TS10
uniprot id: A0A7N9I9D3
uniprot id: G7PQB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9541:RAD23A
gene id: 9541:RAD23A
uniprot id: A0A2K5W9Q8
uniprot id: A0A2K5W9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9541:HDAC8
gene id: 9541:HDAC8
uniprot id: A0A2K5W8N2
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

9541:SFXN5
gene id: 9541:SFXN5
uniprot id: G7PMH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9541:GAR1
gene id: 9541:GAR1
uniprot id: A0A2K5UJ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9541:HPGD
gene id: 9541:HPGD
uniprot id: I7GNJ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:L3MBTL4
gene id: 9541:L3MBTL4
uniprot id: A0A2K5VX15
names: Subcellular Location Annotation
messages: Nucleus

9541:GALNT14
gene id: 9541:GALNT14
uniprot id: A0A7N9C9A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:FOXN2
gene id: 9541:FOXN2
uniprot id: A0A8J8YI45
uniprot id: G7PM65
names: Subcellular Location Annotation
messages: Nucleus

9541:USP1
gene id: 9541:USP1
uniprot id: A0A2K5VG76
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:SLCO2B1
gene id: 9541:SLCO2B1
uniprot id: L7T9F2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PIK3R1
gene id: 9541:PIK3R1
uniprot id: A0A7N9CL43
uniprot id: A0A7N9CVN4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9541:ADGRL3
gene id: 9541:ADGRL3
uniprot id: A0A2K5X4I3
uniprot id: A0A2K5X4I5
uniprot id: A0A2K5X4J3
uniprot id: A0A2K5X4Q5
names: Subcellular Location Annotation
messages: Membrane

9541:SAP130
gene id: 9541:SAP130
uniprot id: A0A2K5U1V3
uniprot id: A0A2K5U1X4
uniprot id: A0A2K5U218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9541:FAM126A
gene id: 9541:FAM126A
uniprot id: A0A2K5ULI0
uniprot id: A0A2K5ULI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9541:MFAP3
gene id: 9541:MFAP3
uniprot id: A0A8J8Y105
uniprot id: G7P8R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:SLC7A5
gene id: 9541:SLC7A5
uniprot id: A0A2K5VWN5
names: Subcellular Location Annotation
messages: Membrane

9541:THBS1
gene id: 9541:THBS1
uniprot id: A0A2K5V619
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ITIH1
gene id: 9541:ITIH1
uniprot id: A0A2K5U480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9541:TBX5
gene id: 9541:TBX5
uniprot id: A0A2K5VPI4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:PPP1CB
gene id: 9541:PPP1CB
uniprot id: A0A2K5VEA0
uniprot id: A0A7N9CGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9541:ITPA
gene id: 9541:ITPA
uniprot id: A0A2K5X2C2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9541:C14H11orf1
gene id: 9541:C14H11orf1
uniprot id: Q4R5Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0686 family.
messages: Nucleus

9541:PDCL2
gene id: 9541:PDCL2
uniprot id: A0A2K5U7V0
names: Similarity
messages: Belongs to the phosducin family.

9541:GLRX
gene id: 9541:GLRX
uniprot id: Q25N99
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9541:MRPS25
gene id: 9541:MRPS25
uniprot id: A0A8J8XC86
uniprot id: G7PIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9541:GPR18
gene id: 9541:GPR18
uniprot id: A0A2K5UFM2
uniprot id: Q4R613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis.

9541:C15H9orf78
gene id: 9541:C15H9orf78
uniprot id: A0A2K5VWM3
uniprot id: G7PRD0
names: Similarity
messages: Belongs to the TLS1 family.

9541:SARAF
gene id: 9541:SARAF
uniprot id: I7GEM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9541:MYO18B
gene id: 9541:MYO18B
uniprot id: A0A2K5TZC8
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:OTOP2
gene id: 9541:OTOP2
uniprot id: A0A2K5VR41
uniprot id: G7PVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9541:UBLCP1
gene id: 9541:UBLCP1
uniprot id: A0A8J8XGL9
uniprot id: G7P6S1
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9541:ECHDC1
gene id: 9541:ECHDC1
uniprot id: A0A2K5UN28
uniprot id: A0A2K5UN41
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:SNAP23
gene id: 9541:SNAP23
uniprot id: G7PB04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9541:LOC102132956
gene id: 9541:LOC102132956
uniprot id: A0A2K5UF57
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9541:GPR55
gene id: 9541:GPR55
uniprot id: A0A8J8XZW1
uniprot id: G7PK96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:GJC1
gene id: 9541:GJC1
uniprot id: A0A2K5UFN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:ZCCHC17
gene id: 9541:ZCCHC17
uniprot id: I7G7J6
uniprot id: I7GK89
uniprot id: Q95KF9
names: Subcellular Location Annotation
names: Subunit
messages: May interact with PNN. May associate with the 60 S ribosomal subunit (By similarity).
messages: nucleolus

9541:GFRA1
gene id: 9541:GFRA1
uniprot id: A0A2K5TWP3
uniprot id: A0A2K5TWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9541:NPC1L1
gene id: 9541:NPC1L1
uniprot id: A0MJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9541:RIMKLB
gene id: 9541:RIMKLB
uniprot id: A0A2K5X5J2
names: Similarity
messages: Belongs to the RimK family.

9541:LACTB2
gene id: 9541:LACTB2
uniprot id: A0A8J8XH33
uniprot id: G7PC06
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9541:COPS5
gene id: 9541:COPS5
uniprot id: A0A8J8YCP6
uniprot id: G7PBZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9541:TMEM229B
gene id: 9541:TMEM229B
uniprot id: A0A2K5UEI4
uniprot id: A0A7N9D440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9541:LOC102145267
gene id: 9541:LOC102145267
uniprot id: A0A2K5WEU2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:CDYL2
gene id: 9541:CDYL2
uniprot id: A0A2K5WXV8
names: Subcellular Location Annotation
messages: Nucleus

9541:DSG3
gene id: 9541:DSG3
uniprot id: A0A2K5UXA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9541:CDH15
gene id: 9541:CDH15
uniprot id: A0A2K5UJ87
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:PON1
gene id: 9541:PON1
uniprot id: A0A8J8YQD9
uniprot id: G7P1C5
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9541:ATP6V0D2
gene id: 9541:ATP6V0D2
uniprot id: A0A2K5V996
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:DYNC1I2
gene id: 9541:DYNC1I2
uniprot id: A0A2K5WRP0
uniprot id: A0A2K5WRQ2
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9541:SYNDIG1
gene id: 9541:SYNDIG1
uniprot id: G7PH54
uniprot id: I7GHI6
uniprot id: Q4R532
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CD225/Dispanin family.
messages: Cell membrane
messages: Early endosome membrane
messages: Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).
messages: May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.
messages: Postsynaptic density membrane
messages: Synapse
messages: dendrite
messages: dendritic spine

9541:RBPJL
gene id: 9541:RBPJL
uniprot id: A0A2K5WU64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9541:SLC12A5
gene id: 9541:SLC12A5
uniprot id: A0A2K5U2B4
uniprot id: A0A2K5U2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:EPB42
gene id: 9541:EPB42
uniprot id: A0A2K5VE29
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

9541:RNF31
gene id: 9541:RNF31
uniprot id: A0A7N9CDH5
uniprot id: A0A8J8Y808
uniprot id: G7P9X8
names: Similarity
messages: Belongs to the RBR family.

9541:GPR119
gene id: 9541:GPR119
uniprot id: A0A8J8XTZ9
uniprot id: G7Q3P2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:KCNMB3
gene id: 9541:KCNMB3
uniprot id: A0A2K5U386
uniprot id: A0A2K5U398
uniprot id: A0A2K5U3A2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9541:RAB33A
gene id: 9541:RAB33A
uniprot id: A0A8J8XQ87
uniprot id: G7Q3N9
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9541:LOC102143706
gene id: 9541:LOC102143706
uniprot id: G7PRN4
uniprot id: I7G5H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9541:LAMA4
gene id: 9541:LAMA4
uniprot id: A0A2K5W4S5
names: Caution
names: Function
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TYR
gene id: 9541:TYR
uniprot id: A0A2K5VT29
uniprot id: G7PNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9541:CD4
gene id: 9541:CD4
uniprot id: A0A8J8YDH1
uniprot id: G7PJN3
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.

9541:KMT5C
gene id: 9541:KMT5C
uniprot id: A0A2K5U5P8
names: Subcellular Location Annotation
messages: Nucleus

9541:TRAPPC2B
gene id: 9541:TRAPPC2B
uniprot id: I7G790
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9541:ALKBH6
gene id: 9541:ALKBH6
uniprot id: A0A2K5W013
names: Similarity
messages: Belongs to the alkB family.

9541:MMP9
gene id: 9541:MMP9
uniprot id: A0A2K5UU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9541:ADD3
gene id: 9541:ADD3
uniprot id: A0A2K5UVU2
uniprot id: A0A2K5UVU3
uniprot id: G7PDY1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9541:SPATS2
gene id: 9541:SPATS2
uniprot id: A0A2K5VZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9541:CAPZA3
gene id: 9541:CAPZA3
uniprot id: G7PJZ7
uniprot id: Q4R7M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5 (By similarity).

9541:HSPB1
gene id: 9541:HSPB1
uniprot id: I7GIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9541:RER1
gene id: 9541:RER1
uniprot id: A0A2K5V184
uniprot id: G7NT94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9541:PLD5
gene id: 9541:PLD5
uniprot id: A0A2K5WPG7
uniprot id: G7NWL7
names: Similarity
messages: Belongs to the phospholipase D family.

9541:LOC102120655
gene id: 9541:LOC102120655
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:WNT3
gene id: 9541:WNT3
uniprot id: A0A2K5UNJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:SLC51A
gene id: 9541:SLC51A
uniprot id: A0A7N9DE93
names: Subcellular Location Annotation
messages: Membrane

9541:FAM133B
gene id: 9541:FAM133B
uniprot id: A0A2K5WBD7
names: Similarity
messages: Belongs to the FAM133 family.

9541:FBP1
gene id: 9541:FBP1
uniprot id: A0A2K5V701
names: Similarity
messages: Belongs to the FBPase class 1 family.

9541:LOC102144583
gene id: 9541:LOC102144583
uniprot id: A0A8J8YCN9
uniprot id: G7NTR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:RPRD1B
gene id: 9541:RPRD1B
uniprot id: A0A8J8YRX8
uniprot id: G7PGE9
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9541:ITM2C
gene id: 9541:ITM2C
uniprot id: Q25PJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9541:ERO1A
gene id: 9541:ERO1A
uniprot id: A0A2K5UA33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9541:HSPB2
gene id: 9541:HSPB2
uniprot id: A0A2K5WCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9541:SLC37A2
gene id: 9541:SLC37A2
uniprot id: A0A2K5TYE4
uniprot id: A0A2K5TYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9541:TBK1
gene id: 9541:TBK1
uniprot id: A0A2K5UYJ5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SFN
gene id: 9541:SFN
uniprot id: A0A2K5UH26
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:INPPL1
gene id: 9541:INPPL1
uniprot id: A0A2K5WJT9
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: spindle pole

9541:LUC7L
gene id: 9541:LUC7L
uniprot id: A0A2K5WBM3
uniprot id: A0A2K5WBP6
names: Similarity
messages: Belongs to the Luc7 family.

9541:LOC102117144
gene id: 9541:LOC102117144
uniprot id: G7P2Q3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CAPN10
gene id: 9541:CAPN10
uniprot id: Q95LP4
names: Function
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).

9541:KRT8
gene id: 9541:KRT8
uniprot id: A0A2K5TS68
uniprot id: A0A7N9CB91
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MPP3
gene id: 9541:MPP3
uniprot id: A0A2K5WE78
names: Similarity
messages: Belongs to the MAGUK family.

9541:ABCC9
gene id: 9541:ABCC9
uniprot id: A0A2K5VZ71
uniprot id: A0A2K5VZC3
uniprot id: A0A2K5VZD7
names: Subunit
messages: Interacts with KCNJ11.

9541:LOC102126833
gene id: 9541:LOC102126833
uniprot id: A0A2K5UQJ1
uniprot id: I7GL91
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

9541:GTF2A1
gene id: 9541:GTF2A1
uniprot id: A0A2K5TKH3
uniprot id: A0A2K5TKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Belongs to the TFIIA subunit 1 family.
messages: Cytoplasm
messages: Nucleus

9541:CRHR2
gene id: 9541:CRHR2
uniprot id: A0A2K5WRX5
uniprot id: A0A2K5WS31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9541:LYRM4
gene id: 9541:LYRM4
uniprot id: A0A2K5TXT9
uniprot id: A0A7N9CNF5
names: Similarity
messages: Belongs to the complex I LYR family.

9541:LOC102120909
gene id: 9541:LOC102120909
uniprot id: Q4W8A3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Expressed in kidney; in the basolateral membrane of the proximal tubule.
messages: Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane (By similarity).
messages: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity). Also mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), and edaravone sulfate (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), cimetidine (CMD), indoxyl sulfate (IS), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF). PAH uptake is inhibited by furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), diclofenac, carprofen, sulindac, calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), glutarate and alpha-ketoglutarate (By similarity).
messages: Multiple cysteine residues are necessary for proper targeting to the plasma membrane.

9541:MED28
gene id: 9541:MED28
uniprot id: A0A2K5WQA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9541:ATP6V1C1
gene id: 9541:ATP6V1C1
uniprot id: G7PCG4
uniprot id: Q4R5H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9541:PTCD2
gene id: 9541:PTCD2
uniprot id: A0A7N9CFC3
uniprot id: I7GIK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9541:LAMTOR1
gene id: 9541:LAMTOR1
uniprot id: A0A2K5TJG8
uniprot id: G7PR11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC15 family.
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9541:LOC102138671
gene id: 9541:LOC102138671
uniprot id: I7GJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9541:TNP2
gene id: 9541:TNP2
uniprot id: Q8WNV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 2 family.
messages: Chromosome
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.
messages: nucleolus

9541:GTF2A2
gene id: 9541:GTF2A2
uniprot id: A0A2K5WHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9541:TRMT6
gene id: 9541:TRMT6
uniprot id: A0A8J8XZJ3
uniprot id: G7PGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9541:PNRC1
gene id: 9541:PNRC1
uniprot id: Q4R4L2
names: Subcellular Location Annotation
messages: Nucleus

9541:DNAL4
gene id: 9541:DNAL4
uniprot id: A0A2K5V5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9541:AKIRIN2
gene id: 9541:AKIRIN2
uniprot id: A0A2K5UJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9541:PEDS1
gene id: 9541:PEDS1
uniprot id: I7GNR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9541:ACTA2
gene id: 9541:ACTA2
uniprot id: A0A2K5U1C8
names: Similarity
messages: Belongs to the actin family.

9541:POMC
gene id: 9541:POMC
uniprot id: A0A2K5X883
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

9541:NLRP3
gene id: 9541:NLRP3
uniprot id: A0A2K5WM90
names: Similarity
messages: Belongs to the NLRP family.

9541:PHC1
gene id: 9541:PHC1
uniprot id: A0A2K5UF17
uniprot id: G7PJR2
names: Subcellular Location Annotation
messages: Nucleus

9541:RPS3A
gene id: 9541:RPS3A
uniprot id: Q4R4Z6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9541:PROKR2
gene id: 9541:PROKR2
uniprot id: A0A2K5TRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:RTF2
gene id: 9541:RTF2
uniprot id: A0A2K5TYR6
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9541:CD34
gene id: 9541:CD34
uniprot id: A0A2K5UCU4
names: Subcellular Location Annotation
messages: Membrane

9541:CUL1
gene id: 9541:CUL1
uniprot id: A0A2K5WRW3
uniprot id: A0A7N9CNI7
names: Similarity
messages: Belongs to the cullin family.

9541:MPP7
gene id: 9541:MPP7
uniprot id: A0A2K5VQA8
uniprot id: G7PEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9541:SSR2
gene id: 9541:SSR2
uniprot id: G7NV73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9541:EDEM3
gene id: 9541:EDEM3
uniprot id: A0A2K5V1I7
uniprot id: A0A2K5V1K9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:SPACA3
gene id: 9541:SPACA3
uniprot id: A0A2K5TVB4
uniprot id: A0A2K5TVB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

9541:GPAM
gene id: 9541:GPAM
uniprot id: A0A2K5V1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9541:RAD18
gene id: 9541:RAD18
uniprot id: A0A2K5UMD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9541:GRHPR
gene id: 9541:GRHPR
uniprot id: A0A2K5V7Q6
uniprot id: A0A2K5V7S5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9541:GSTCD
gene id: 9541:GSTCD
uniprot id: A0A2K5X8G8
uniprot id: Q4R6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSTCD family.
messages: Cytoplasm

9541:CKS1B
gene id: 9541:CKS1B
uniprot id: A0A7N9DBP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9541:TMEM168
gene id: 9541:TMEM168
uniprot id: A0A2K5UIL0
uniprot id: A0A8J8XBZ6
uniprot id: G7P2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9541:SLC25A2
gene id: 9541:SLC25A2
uniprot id: A0A2K5UKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:SERPINB5
gene id: 9541:SERPINB5
uniprot id: A0A2K5VSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9541:EIF1AD
gene id: 9541:EIF1AD
uniprot id: Q4R354
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Nucleus
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).

9541:CFB
gene id: 9541:CFB
uniprot id: A0A2K5TZY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:CTSD
gene id: 9541:CTSD
uniprot id: I7G2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9541:ARG2
gene id: 9541:ARG2
uniprot id: I7GPI4
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9541:MYOD1
gene id: 9541:MYOD1
uniprot id: A0A2K5X3Q3
names: Subcellular Location Annotation
messages: Nucleus

9541:CIT
gene id: 9541:CIT
uniprot id: A0A2K5U1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9541:ELAC2
gene id: 9541:ELAC2
uniprot id: Q8HY87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase Z family.
messages: Homodimer. Interacts with PTCD1.
messages: Mitochondrion
messages: Nucleus
messages: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
messages: mitochondrion nucleoid

9541:NCAPH
gene id: 9541:NCAPH
uniprot id: Q4R332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9541:MFSD14B
gene id: 9541:MFSD14B
uniprot id: A0A2K5VC27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:GLIPR1L1
gene id: 9541:GLIPR1L1
uniprot id: A0A2K5UUU6
names: Similarity
messages: Belongs to the CRISP family.

9541:MCTP2
gene id: 9541:MCTP2
uniprot id: A0A2K5VJI3
uniprot id: G7P9I2
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102136728
gene id: 9541:LOC102136728
uniprot id: A0A2K5TN42
names: Similarity
messages: Belongs to the KHDC1 family.

9541:TAF7
gene id: 9541:TAF7
uniprot id: G7P8I3
uniprot id: Q4R5A5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF7 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF1; the interaction is direct. Interacts with TAF1, TAF5, TAF11, TAF12, and TAF13, but not with TAF10 or TBP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CIITA and TAF1 and inhibits their acetyltransferase activity, and behaving as a repressor of CIITA- and TAF1-regulated promoters.
messages: Nucleus
messages: Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).

9541:KRT35
gene id: 9541:KRT35
uniprot id: A0A2K5X7X7
names: Similarity
messages: Belongs to the intermediate filament family.

9541:CFAP36
gene id: 9541:CFAP36
uniprot id: I7GAR5
names: Similarity
messages: Belongs to the CFAP36 family.

9541:ATXN2
gene id: 9541:ATXN2
uniprot id: A0A2K5X800
names: Similarity
messages: Belongs to the ataxin-2 family.

9541:CEP63
gene id: 9541:CEP63
uniprot id: A0A2K5TQF1
uniprot id: A0A2K5TQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: centriolar satellite

9541:LOC102138406
gene id: 9541:LOC102138406
uniprot id: G7P2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MINDY4
gene id: 9541:MINDY4
uniprot id: A0A2K5UFI6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9541:SHROOM4
gene id: 9541:SHROOM4
uniprot id: A0A2K5VYG0
uniprot id: A0A2K5VYH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9541:PPM1L
gene id: 9541:PPM1L
uniprot id: A0A8J8YJJ4
uniprot id: G7NZI0
names: Similarity
messages: Belongs to the PP2C family.

9541:HOGA1
gene id: 9541:HOGA1
uniprot id: A0A2K5W8D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9541:REV1
gene id: 9541:REV1
uniprot id: A0A2K5VGG2
uniprot id: A0A2K5VGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9541:TMEM255A
gene id: 9541:TMEM255A
uniprot id: A0A2K5TMD0
uniprot id: A0A2K5TMD5
uniprot id: Q9BE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9541:RANBP10
gene id: 9541:RANBP10
uniprot id: A0A2K5VBP7
names: Similarity
messages: Belongs to the RANBP9/10 family.

9541:EXOSC2
gene id: 9541:EXOSC2
uniprot id: A0A2K5X8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9541:FREM2
gene id: 9541:FREM2
uniprot id: A0A2K5U0Q1
uniprot id: A0A2K5U0W9
names: Similarity
messages: Belongs to the FRAS1 family.

9541:PDZK1IP1
gene id: 9541:PDZK1IP1
uniprot id: A0A2K5TZ39
uniprot id: G8F516
names: Subcellular Location Annotation
messages: Membrane

9541:DESI2
gene id: 9541:DESI2
uniprot id: A0A2K5V2W7
uniprot id: G8F4C7
names: Similarity
messages: Belongs to the DeSI family.

9541:ZNF383
gene id: 9541:ZNF383
uniprot id: Q4R6C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
messages: Nucleus
messages: The KRAB domain is responsible for the transcriptional repressor activity.

9541:PSMC2
gene id: 9541:PSMC2
uniprot id: Q4R4R0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Monoubiquitinated by RNF181.
messages: Nucleus

9541:SIN3B
gene id: 9541:SIN3B
uniprot id: A0A2K5U753
uniprot id: A0A2K5U768
names: Subcellular Location Annotation
messages: Nucleus

9541:CLCN5
gene id: 9541:CLCN5
uniprot id: A0A2K5UX41
uniprot id: A0A2K5UXD4
uniprot id: G7Q2R0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:RIC8B
gene id: 9541:RIC8B
uniprot id: A0A2K5WDJ2
uniprot id: A0A2K5WDJ4
uniprot id: A0A2K5WDN4
uniprot id: A0A2K5WDN6
uniprot id: A0A2K5WDW8
uniprot id: A0A7N9CPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9541:ACVR1C
gene id: 9541:ACVR1C
uniprot id: A0A2K5VZI1
uniprot id: A0A2K5VZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:ARL6
gene id: 9541:ARL6
uniprot id: A0A2K5VB91
uniprot id: A0A8J8XKV2
uniprot id: G7NZ67
uniprot id: I7GKS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9541:LOC102138968
gene id: 9541:LOC102138968
uniprot id: A0A2K5VE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9541:LOC102147244
gene id: 9541:LOC102147244
uniprot id: A0A2K5TYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9541:KDSR
gene id: 9541:KDSR
uniprot id: A0A7N9IDX9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:AKT2
gene id: 9541:AKT2
uniprot id: A0A2K5WA57
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9541:WDR82
gene id: 9541:WDR82
uniprot id: A0A7N9CXF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9541:SCML4
gene id: 9541:SCML4
uniprot id: A0A2K5X988
names: Subcellular Location Annotation
messages: Nucleus

9541:ZMYND10
gene id: 9541:ZMYND10
uniprot id: A0A2K5X6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9541:VPS41
gene id: 9541:VPS41
uniprot id: A0A2K5WXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9541:DEF8
gene id: 9541:DEF8
uniprot id: I7G4B3
names: Similarity
messages: Belongs to the DEF8 family.

9541:ICAM2
gene id: 9541:ICAM2
uniprot id: A0A2K5WE44
uniprot id: G8F5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9541:POU3F4
gene id: 9541:POU3F4
uniprot id: G7Q354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9541:LOC102120368
gene id: 9541:LOC102120368
uniprot id: A0A2K5UN85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:LDB1
gene id: 9541:LDB1
uniprot id: A0A2K5WUY6
uniprot id: A0A2K5WV57
uniprot id: G7PDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9541:CD3D
gene id: 9541:CD3D
uniprot id: A0A2K5VUZ5
uniprot id: G7PP34
uniprot id: Q95LI8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.
messages: Cell membrane
messages: Membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with coreceptors CD4 and CD8.

9541:OPN3
gene id: 9541:OPN3
uniprot id: A0A2K5VXZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:SMARCA5
gene id: 9541:SMARCA5
uniprot id: A0A2K5VI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9541:PGGT1B
gene id: 9541:PGGT1B
uniprot id: A0A2K5WTH1
uniprot id: G7P826
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9541:DNASE1L2
gene id: 9541:DNASE1L2
uniprot id: A0A2K5V1N6
names: Similarity
messages: Belongs to the DNase I family.

9541:LOC102117187
gene id: 9541:LOC102117187
uniprot id: A0A2K5UPR2
uniprot id: G7NTR4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:XPO6
gene id: 9541:XPO6
uniprot id: A0A2K5VRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9541:PLOD3
gene id: 9541:PLOD3
uniprot id: A0A2K5V7U6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:EXOC3L1
gene id: 9541:EXOC3L1
uniprot id: A0A2K5U0H9
names: Similarity
messages: Belongs to the SEC6 family.

9541:LOC101925125
gene id: 9541:LOC101925125
uniprot id: A0A2K5VY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9541:IGF2BP3
gene id: 9541:IGF2BP3
uniprot id: A0A2K5W6T2
uniprot id: A0A7N9CA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9541:LOC102144656
gene id: 9541:LOC102144656
uniprot id: A0A2K5X814
names: Similarity
messages: Belongs to the GAGE family.

9541:ANO4
gene id: 9541:ANO4
uniprot id: A0A2K5TK58
uniprot id: A0A2K5TK63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NDUFA5
gene id: 9541:NDUFA5
uniprot id: Q4R5J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:RIPPLY2
gene id: 9541:RIPPLY2
uniprot id: A0A2K5WUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9541:CRKL
gene id: 9541:CRKL
uniprot id: A0A8J8YEB0
uniprot id: G7PHA6
names: Similarity
messages: Belongs to the CRK family.

9541:ZNF75A
gene id: 9541:ZNF75A
uniprot id: G7Q0C4
names: Subcellular Location Annotation
messages: Nucleus

9541:ADCK1
gene id: 9541:ADCK1
uniprot id: A0A2K5WAW9
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9541:NR0B1
gene id: 9541:NR0B1
uniprot id: A0A2K5V0Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9541:MSH5
gene id: 9541:MSH5
uniprot id: A0A2K5TPJ3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9541:ADAMTS13
gene id: 9541:ADAMTS13
uniprot id: A0A2K5TNC6
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Secreted

9541:LELP1
gene id: 9541:LELP1
uniprot id: Q4R956
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9541:HOXD10
gene id: 9541:HOXD10
uniprot id: A0A2K5UTS0
uniprot id: G7PKW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:CD36
gene id: 9541:CD36
uniprot id: A0A8J8XGH3
uniprot id: Q4R6B4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9541:GTF2H2
gene id: 9541:GTF2H2
uniprot id: A0A2K5U6X1
uniprot id: G7P7P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9541:AP3B2
gene id: 9541:AP3B2
uniprot id: A0A2K5U1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9541:TEN1
gene id: 9541:TEN1
uniprot id: A0A2K5WND5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:MAPK4
gene id: 9541:MAPK4
uniprot id: A0A2K5TNV1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9541:ZNF687
gene id: 9541:ZNF687
uniprot id: A0A2K5WG95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:PSMD3
gene id: 9541:PSMD3
uniprot id: A0A2K5TLI1
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9541:F13A1
gene id: 9541:F13A1
uniprot id: A0A2K5U7L6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9541:CERS6
gene id: 9541:CERS6
uniprot id: A0A2K5WS77
uniprot id: A0A7N9DG37
uniprot id: A0A8J8YJ84
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:PNMT
gene id: 9541:PNMT
uniprot id: A0A2K5W5P1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9541:UROS
gene id: 9541:UROS
uniprot id: A0A2K5VG84
uniprot id: A0A7N9C9Y7
uniprot id: A0A7N9D060
uniprot id: A0A7N9D6H7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9541:LOC102121517
gene id: 9541:LOC102121517
uniprot id: G7P2L9
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:MRPS12
gene id: 9541:MRPS12
uniprot id: A0A8J8XQN7
uniprot id: G7PXI2
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9541:IP6K1
gene id: 9541:IP6K1
uniprot id: A0A2K5TSG4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:VPS33A
gene id: 9541:VPS33A
uniprot id: Q4R7U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9541:LOC102143000
gene id: 9541:LOC102143000
uniprot id: A0A8J8Y5C1
uniprot id: G7PMS9
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9541:INTS9
gene id: 9541:INTS9
uniprot id: A0A2K5VH01
uniprot id: Q4R5Z4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).
messages: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
messages: Nucleus

9541:TMEM106C
gene id: 9541:TMEM106C
uniprot id: A0A8J8XK76
uniprot id: G7PHP8
names: Similarity
messages: Belongs to the TMEM106 family.

9541:AGT
gene id: 9541:AGT
uniprot id: I7GH44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9541:HOXB8
gene id: 9541:HOXB8
uniprot id: A0A2K5V8D3
names: Subcellular Location Annotation
messages: Nucleus

9541:ISM2
gene id: 9541:ISM2
uniprot id: A0A2K5X3N4
names: Similarity
messages: Belongs to the isthmin family.

9541:FAM241B
gene id: 9541:FAM241B
uniprot id: A0A2K5V1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9541:LOC102134569
gene id: 9541:LOC102134569
uniprot id: A0A2K5UQZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9541:PAFAH1B1
gene id: 9541:PAFAH1B1
uniprot id: Q8HXX0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9541:LOC102146206
gene id: 9541:LOC102146206
uniprot id: Q9GKV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KCNAB1
gene id: 9541:KCNAB1
uniprot id: A0A2K5V0E9
uniprot id: A0A2K5V0F2
uniprot id: A0A2K5V0K6
uniprot id: I7GK52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Monomer.

9541:LOC102134986
gene id: 9541:LOC102134986
uniprot id: A0A2K5UFV7
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9541:TAF8
gene id: 9541:TAF8
uniprot id: A0A2K5U5F7
uniprot id: A0A7N9DFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9541:MSRA
gene id: 9541:MSRA
uniprot id: Q2PFZ6
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9541:LIAS
gene id: 9541:LIAS
uniprot id: A0A2K5WF34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9541:LOC102119459
gene id: 9541:LOC102119459
uniprot id: A0A2K5W4A4
uniprot id: A0A2K5W4A5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9541:BAZ2A
gene id: 9541:BAZ2A
uniprot id: A0A2K5UPU3
uniprot id: A0A2K5UPV6
uniprot id: A0A2K5UQ15
names: Similarity
messages: Belongs to the WAL family.

9541:WDR55
gene id: 9541:WDR55
uniprot id: A0A2K5U921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9541:CYP11A1
gene id: 9541:CYP11A1
uniprot id: Q2XV99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9541:CTSH
gene id: 9541:CTSH
uniprot id: A0A2K5TRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9541:ZBTB8OS
gene id: 9541:ZBTB8OS
uniprot id: A0A2K5V6L5
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9541:TUBA1B
gene id: 9541:TUBA1B
uniprot id: Q25MB8
uniprot id: Q4R538
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Belongs to the tubulin family.
messages: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Nascent tubulin polypeptide interacts (via beta-tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation.
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

9541:EXOSC7
gene id: 9541:EXOSC7
uniprot id: A0A8J8XTH2
uniprot id: G7NY47
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SERPINB8
gene id: 9541:SERPINB8
uniprot id: A0A2K5V7F4
names: Similarity
messages: Belongs to the serpin family.

9541:NLGN4X
gene id: 9541:NLGN4X
uniprot id: A0A2K5WKF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9541:PDE11A
gene id: 9541:PDE11A
uniprot id: A0A8J8YBB3
uniprot id: G7PKX5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:PYCR3
gene id: 9541:PYCR3
uniprot id: I7GL29
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9541:SLC25A48
gene id: 9541:SLC25A48
uniprot id: A0A2K5WJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:HADHB
gene id: 9541:HADHB
uniprot id: A0A158SIP4
uniprot id: Q8HXX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Endoplasmic reticulum
messages: Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN. Interacts with RSAD2/viperin.
messages: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9541:CCDC70
gene id: 9541:CCDC70
uniprot id: Q4R9C9
names: Caution
names: Subcellular Location Annotation
messages: It is uncertain whether Met-1 or Met-12 is the initiator.
messages: Mitochondrion

9541:RORB
gene id: 9541:RORB
uniprot id: A0A2K5WSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:PELP1
gene id: 9541:PELP1
uniprot id: A0A2K5U1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

9541:LOC102144453
gene id: 9541:LOC102144453
uniprot id: A0A7N9IDK4
names: Subcellular Location Annotation
messages: Nucleus

9541:GNB1
gene id: 9541:GNB1
uniprot id: G7NWS9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9541:SENP3
gene id: 9541:SENP3
uniprot id: A0A2K5U0I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9541:PTAR1
gene id: 9541:PTAR1
uniprot id: A0A2K5U4L5
uniprot id: A0A2K5U4M3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9541:LYRM1
gene id: 9541:LYRM1
uniprot id: A0A2K5WA91
uniprot id: G7Q0N4
names: Similarity
messages: Belongs to the complex I LYR family.

9541:CD46
gene id: 9541:CD46
uniprot id: A0A2K5WCL8
uniprot id: A0A2K5WCM2
uniprot id: A0A2K5WCS2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9541:PLCG2
gene id: 9541:PLCG2
uniprot id: A0A2K5W153
uniprot id: G7PZU5
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9541:GSG1
gene id: 9541:GSG1
uniprot id: A0A2K5WY31
uniprot id: A0A2K5WY44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9541:ZHX2
gene id: 9541:ZHX2
uniprot id: G7PCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9541:SEC31B
gene id: 9541:SEC31B
uniprot id: A0A2K5VGB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9541:SIN3A
gene id: 9541:SIN3A
uniprot id: A0A2K5U3F5
names: Subcellular Location Annotation
messages: Nucleus

9541:JPT1
gene id: 9541:JPT1
uniprot id: A0A2K5V9L0
uniprot id: A0A2K5V9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9541:LOC102122596
gene id: 9541:LOC102122596
uniprot id: A0A2K5UUZ8
names: Similarity
messages: Belongs to the UPF0488 family.

9541:GPAT4
gene id: 9541:GPAT4
uniprot id: A0A2K5WA72
uniprot id: A0A7N9DCX4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9541:SMIM19
gene id: 9541:SMIM19
uniprot id: A0A8J8XIJ5
uniprot id: G7PBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9541:HNMT
gene id: 9541:HNMT
uniprot id: A0A2K5VBJ8
uniprot id: I7GMY1
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9541:CYP4F8
gene id: 9541:CYP4F8
uniprot id: A0A2K5WU79
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:TPST1
gene id: 9541:TPST1
uniprot id: A0A2K5W8G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9541:SENP2
gene id: 9541:SENP2
uniprot id: A0A2K5W659
names: Similarity
messages: Belongs to the peptidase C48 family.

9541:TIPRL
gene id: 9541:TIPRL
uniprot id: A0A2K5VUG0
names: Similarity
messages: Belongs to the TIP41 family.

9541:UBE2D1
gene id: 9541:UBE2D1
uniprot id: A0A2K5VRH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:SATB2
gene id: 9541:SATB2
uniprot id: A0A2K5VBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9541:NPY2R
gene id: 9541:NPY2R
uniprot id: A0A2K5UGU6
uniprot id: G7P6G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102122758
gene id: 9541:LOC102122758
uniprot id: A0A2K5X1L0
uniprot id: A0A7N9I9L6
names: Similarity
messages: Belongs to the fl(2)d family.

9541:SARS2
gene id: 9541:SARS2
uniprot id: Q4R4T1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9541:FGGY
gene id: 9541:FGGY
uniprot id: A0A2K5WK13
names: Similarity
messages: Belongs to the FGGY kinase family.

9541:GSK3B
gene id: 9541:GSK3B
uniprot id: A0A2K5U1P9
uniprot id: A0A2K5U1V1
uniprot id: A0A2K5U1X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:AKR7A3
gene id: 9541:AKR7A3
uniprot id: A0A2K5TSB5
names: Subunit
messages: Monomer.

9541:WNT1
gene id: 9541:WNT1
uniprot id: A0A8J8XZH3
uniprot id: G7PHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:LIM2
gene id: 9541:LIM2
uniprot id: A0A8J8Y6W6
uniprot id: G7PYH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9541:TCTN2
gene id: 9541:TCTN2
uniprot id: A0A2K5UYQ3
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9541:MYOG
gene id: 9541:MYOG
uniprot id: A0A2K5VH44
names: Subcellular Location Annotation
messages: Nucleus

9541:CYGB
gene id: 9541:CYGB
uniprot id: A0A2K5W989
uniprot id: A0A2K5W9D1
names: Similarity
messages: Belongs to the globin family.

9541:HNRNPA2B1
gene id: 9541:HNRNPA2B1
uniprot id: A0A2K5U0D5
uniprot id: I7G895
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9541:RPS12
gene id: 9541:RPS12
uniprot id: A0A8J8YCC6
uniprot id: G7P346
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9541:TMEM265
gene id: 9541:TMEM265
uniprot id: A0A2K5WDS6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:RC3H1
gene id: 9541:RC3H1
uniprot id: A0A2K5WM56
names: Subcellular Location Annotation
messages: P-body

9541:ODR4
gene id: 9541:ODR4
uniprot id: A0A2K5V8C2
uniprot id: A0A2K5V8C9
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9541:HSD3B2
gene id: 9541:HSD3B2
uniprot id: Q2XQY4
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9541:LOC102116377
gene id: 9541:LOC102116377
uniprot id: A0A2K5X1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:RPS6KA4
gene id: 9541:RPS6KA4
uniprot id: A0A2K5U291
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SV2A
gene id: 9541:SV2A
uniprot id: A0A2K5WGW9
uniprot id: G7NTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9541:RAB2A
gene id: 9541:RAB2A
uniprot id: Q4R4X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
messages: acrosome

9541:DEFB1
gene id: 9541:DEFB1
uniprot id: P61261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9541:SLC5A3
gene id: 9541:SLC5A3
uniprot id: A0A2K5UHR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9541:HS6ST3
gene id: 9541:HS6ST3
uniprot id: A0A2K5X627
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9541:HBE1
gene id: 9541:HBE1
uniprot id: A0A2K5WIW1
uniprot id: G8F3D2
names: Similarity
messages: Belongs to the globin family.

9541:FKBP6
gene id: 9541:FKBP6
uniprot id: A0A2K5W696
uniprot id: A0A8J8XF26
uniprot id: G7P173
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

9541:INO80
gene id: 9541:INO80
uniprot id: A0A2K5VMV7
uniprot id: G7PAY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9541:LOC102133286
gene id: 9541:LOC102133286
uniprot id: A0A8J8XD17
uniprot id: G7Q3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:DNASE1
gene id: 9541:DNASE1
uniprot id: A0A7N9CGN5
uniprot id: A0A7N9I9E6
names: Similarity
messages: Belongs to the DNase I family.

9541:TMEM129
gene id: 9541:TMEM129
uniprot id: A0A2K5X7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9541:SLC35F4
gene id: 9541:SLC35F4
uniprot id: A0A2K5TUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9541:MOK
gene id: 9541:MOK
uniprot id: Q4R5J8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:HOMER1
gene id: 9541:HOMER1
uniprot id: A0A2K5U708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9541:SPTAN1
gene id: 9541:SPTAN1
uniprot id: A0A2K5VKZ4
uniprot id: A0A2K5VL04
uniprot id: A0A2K5VL15
uniprot id: A0A2K5VL65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9541:TBCB
gene id: 9541:TBCB
uniprot id: I7GAX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9541:SEC24C
gene id: 9541:SEC24C
uniprot id: A0A2K5U7M0
uniprot id: A0A7N9D9T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:LOC102115806
gene id: 9541:LOC102115806
uniprot id: A0A2K5WPB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9541:TRHDE
gene id: 9541:TRHDE
uniprot id: A0A2K5VLJ7
names: Similarity
messages: Belongs to the peptidase M1 family.

9541:LZIC
gene id: 9541:LZIC
uniprot id: A0A2K5WIK2
uniprot id: G7NU54
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9541:USP9X
gene id: 9541:USP9X
uniprot id: A0A2K5V070
uniprot id: G7Q2J0
names: Similarity
messages: Belongs to the peptidase C19 family.

9541:PSMB7
gene id: 9541:PSMB7
uniprot id: I7GL24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9541:SPIC
gene id: 9541:SPIC
uniprot id: A0A2K5WBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:CERS3
gene id: 9541:CERS3
uniprot id: A0A2K5VI72
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:SSH2
gene id: 9541:SSH2
uniprot id: A0A2K5V7B4
uniprot id: A0A2K5V7B9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9541:TMEM63B
gene id: 9541:TMEM63B
uniprot id: A0A7N9ICI8
uniprot id: A0A8J8YDD7
uniprot id: G7P403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9541:LOC102127570
gene id: 9541:LOC102127570
uniprot id: A0A2K5WKI9
names: Similarity
messages: Belongs to the intermediate filament family.

9541:HLF
gene id: 9541:HLF
uniprot id: A0A2K5V5N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9541:ISCA1
gene id: 9541:ISCA1
uniprot id: Q4R5F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Interacts with CRY2, but not with CRY1 (in vitro).
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion

9541:TMEM53
gene id: 9541:TMEM53
uniprot id: A0A8J8XIR8
uniprot id: G7NUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9541:ACP1
gene id: 9541:ACP1
uniprot id: A0A2K5UKD7
uniprot id: A0A7N9IEE2
uniprot id: G7PLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9541:EPHA6
gene id: 9541:EPHA6
uniprot id: A0A2K5U305
names: Subcellular Location Annotation
messages: Membrane

9541:ESYT3
gene id: 9541:ESYT3
uniprot id: A0A2K5TKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:OC90
gene id: 9541:OC90
uniprot id: A0A2K5W4V8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:ST8SIA2
gene id: 9541:ST8SIA2
uniprot id: A0A2K5U7F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:CREG2
gene id: 9541:CREG2
uniprot id: A0A2K5VHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9541:SIM1
gene id: 9541:SIM1
uniprot id: A0A2K5W6D0
names: Subcellular Location Annotation
messages: Nucleus

9541:PLPPR5
gene id: 9541:PLPPR5
uniprot id: A0A2K5W213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:BORCS8
gene id: 9541:BORCS8
uniprot id: A0A2K5TK12
uniprot id: A0A2K5V483
uniprot id: G7PX11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus

9541:CX3CR1
gene id: 9541:CX3CR1
uniprot id: A0A2K5VJQ4
uniprot id: I7G315
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9541:WASF1
gene id: 9541:WASF1
uniprot id: A0A2K5TYW2
uniprot id: G8F546
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:CYFIP2
gene id: 9541:CYFIP2
uniprot id: A0A2K5WQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9541:TFAP2B
gene id: 9541:TFAP2B
uniprot id: A0A2K5WSA6
names: Similarity
messages: Belongs to the AP-2 family.

9541:HK3
gene id: 9541:HK3
uniprot id: A0A2K5U647
names: Similarity
messages: Belongs to the hexokinase family.

9541:GIMAP8
gene id: 9541:GIMAP8
uniprot id: A0A8J8YKR5
uniprot id: G7P201
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9541:FAM110B
gene id: 9541:FAM110B
uniprot id: A0A8J8XF66
uniprot id: G7PBW3
names: Similarity
messages: Belongs to the FAM110 family.

9541:MICOS13
gene id: 9541:MICOS13
uniprot id: G7PYT4
uniprot id: Q2ACH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LOC102127060
gene id: 9541:LOC102127060
uniprot id: Q2I6K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9541:METAP2
gene id: 9541:METAP2
uniprot id: A0A2K5WZJ5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9541:SLC9A8
gene id: 9541:SLC9A8
uniprot id: Q4R8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Golgi apparatus membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

9541:INSRR
gene id: 9541:INSRR
uniprot id: A0A2K5WPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9541:CCM2
gene id: 9541:CCM2
uniprot id: A0A2K5TWK8
uniprot id: A0A2K5TWM1
uniprot id: A0A2K5TWM5
uniprot id: A0A2K5TWN1
uniprot id: A0A2K5TWQ3
uniprot id: A0A7N9CYN3
uniprot id: A0A7N9D2V5
names: Similarity
messages: Belongs to the CCM2 family.

9541:SCN2A
gene id: 9541:SCN2A
uniprot id: A0A2K5TT06
uniprot id: A0A2K5TT46
uniprot id: A0A2K5TT52
uniprot id: A0A2K5U6I4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:NBN
gene id: 9541:NBN
uniprot id: E5FGN1
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9541:CHN2
gene id: 9541:CHN2
uniprot id: A0A2K5V6S1
uniprot id: A0A2K5V6V5
names: Function
messages: GTPase-activating protein for p21-rac.

9541:GPR68
gene id: 9541:GPR68
uniprot id: A0A2K5UC27
uniprot id: G7PBB1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:DNAH12
gene id: 9541:DNAH12
uniprot id: A0A2K5UTV2
names: Similarity
messages: Belongs to the dynein heavy chain family.

9541:EYA4
gene id: 9541:EYA4
uniprot id: A0A2K5TJL8
uniprot id: A0A2K5TJM3
uniprot id: A0A2K5TJP0
uniprot id: A0A2K5TJP4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9541:TBX20
gene id: 9541:TBX20
uniprot id: A0A8J8Y975
uniprot id: G7P0F2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:POP7
gene id: 9541:POP7
uniprot id: A0A8J8XVN3
uniprot id: G7P0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9541:RGMA
gene id: 9541:RGMA
uniprot id: Q9N0A6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Interacts with NEO1, BMP2 and BMP4.
messages: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8 (By similarity).

9541:PCK2
gene id: 9541:PCK2
uniprot id: A0A2K5W9M9
uniprot id: G7P9X2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9541:PIGZ
gene id: 9541:PIGZ
uniprot id: A0A2K5VWI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TUBB6
gene id: 9541:TUBB6
uniprot id: A0A2K5WZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:CD99L2
gene id: 9541:CD99L2
uniprot id: A0A2K5VGR7
uniprot id: A0A2K5VGX9
uniprot id: A0A2K5VGY3
uniprot id: A0A2K5VGY7
names: Similarity
messages: Belongs to the CD99 family.

9541:LPCAT2
gene id: 9541:LPCAT2
uniprot id: I7GNW0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9541:ENDOU
gene id: 9541:ENDOU
uniprot id: A0A2K5TLU3
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9541:EHF
gene id: 9541:EHF
uniprot id: A0A2K5UMJ7
uniprot id: G7PQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:PHC2
gene id: 9541:PHC2
uniprot id: A0A2K5V9L7
uniprot id: A0A2K5V9N5
names: Subcellular Location Annotation
messages: Nucleus

9541:DPRX
gene id: 9541:DPRX
uniprot id: A0A2K5W0A5
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102129652
gene id: 9541:LOC102129652
uniprot id: A0A2K5W2K6
uniprot id: A0A2K5W2L9
uniprot id: A0A2K5W2P4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:G0S2
gene id: 9541:G0S2
uniprot id: A0A2K5UJD9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9541:GPR33
gene id: 9541:GPR33
uniprot id: A0A7N9CK82
names: Subcellular Location Annotation
messages: Cell membrane

9541:PKIA
gene id: 9541:PKIA
uniprot id: I7GME7
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9541:MFN1
gene id: 9541:MFN1
uniprot id: A0A2K5WCF4
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9541:INSL5
gene id: 9541:INSL5
uniprot id: A0A8J8XP35
uniprot id: G7NW30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9541:UBE2B
gene id: 9541:UBE2B
uniprot id: I7GLU2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:FGF14
gene id: 9541:FGF14
uniprot id: A0A2K5WQR6
uniprot id: A0A7N9CAT2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:HHAT
gene id: 9541:HHAT
uniprot id: A0A2K5WBQ5
uniprot id: A0A2K5WBU1
names: Subcellular Location Annotation
messages: Membrane

9541:AXIN2
gene id: 9541:AXIN2
uniprot id: A0A2K5TM22
uniprot id: A0A2K5TM28
uniprot id: A0A7N9CD25
uniprot id: G7PV72
names: Subcellular Location Annotation
messages: Cytoplasm

9541:HTR2C
gene id: 9541:HTR2C
uniprot id: A0A2K5UBW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

9541:THOP1
gene id: 9541:THOP1
uniprot id: A0A2K5W2Y6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9541:SLC18B1
gene id: 9541:SLC18B1
uniprot id: A0A2K5X0N4
uniprot id: G7P347
names: Subcellular Location Annotation
messages: Membrane

9541:SLC35C1
gene id: 9541:SLC35C1
uniprot id: A0A7N9DCB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9541:KIF21B
gene id: 9541:KIF21B
uniprot id: A0A2K5WZ21
uniprot id: A0A2K5WZB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9541:KCTD1
gene id: 9541:KCTD1
uniprot id: A0A2K5W4D2
names: Subcellular Location Annotation
messages: Cell membrane

9541:CFDP1
gene id: 9541:CFDP1
uniprot id: A0A2K5UYF4
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9541:DUSP5
gene id: 9541:DUSP5
uniprot id: A0A2K5TX63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9541:PSME2
gene id: 9541:PSME2
uniprot id: A0A2K5U5Y1
names: Similarity
messages: Belongs to the PA28 family.

9541:LOC102119771
gene id: 9541:LOC102119771
uniprot id: A0A2K5V8L2
names: Similarity
messages: Belongs to the S-100 family.

9541:GABBR1
gene id: 9541:GABBR1
uniprot id: A0A2K5TNP9
uniprot id: A0A7N9DEY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NDUFB5
gene id: 9541:NDUFB5
uniprot id: A0A2K5VYZ1
uniprot id: A0A2K5VYZ5
uniprot id: G7NZ27
uniprot id: Q4R4E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:UBQLN1
gene id: 9541:UBQLN1
uniprot id: A0A2K5WPB3
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9541:GNL1
gene id: 9541:GNL1
uniprot id: Q4R8D2
names: Domain
names: Function
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: Possible regulatory or functional link with the histocompatibility cluster.

9541:GSX1
gene id: 9541:GSX1
uniprot id: A0A2K5W595
names: Subcellular Location Annotation
messages: Nucleus

9541:CREB3L4
gene id: 9541:CREB3L4
uniprot id: Q5UEM8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).

9541:SLAIN2
gene id: 9541:SLAIN2
uniprot id: A0A2K5VZE0
uniprot id: A0A2K5VZH4
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9541:RITA1
gene id: 9541:RITA1
uniprot id: A0A2K5VEZ6
uniprot id: I7G8X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9541:ARHGDIB
gene id: 9541:ARHGDIB
uniprot id: A0A2K5X5E9
uniprot id: G7PJY3
names: Similarity
messages: Belongs to the Rho GDI family.

9541:CPVL
gene id: 9541:CPVL
uniprot id: A0A2K5X870
names: Similarity
messages: Belongs to the peptidase S10 family.

9541:CYP27C1
gene id: 9541:CYP27C1
uniprot id: A0A2K5VX46
uniprot id: G7PLG2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:WIPI2
gene id: 9541:WIPI2
uniprot id: Q4R757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

9541:PSMB5
gene id: 9541:PSMB5
uniprot id: I7GKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:CSH2
gene id: 9541:CSH2
uniprot id: A0A2K5V3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9541:LOC102139903
gene id: 9541:LOC102139903
uniprot id: A0A2K5UPN3
uniprot id: G7P2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:EIF2S1
gene id: 9541:EIF2S1
uniprot id: A0A8J8XGJ1
uniprot id: G7PAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9541:CLCA2
gene id: 9541:CLCA2
uniprot id: A0A2K5TWV9
names: Similarity
messages: Belongs to the CLCR family.

9541:STARD3
gene id: 9541:STARD3
uniprot id: A0A2K5VBN4
uniprot id: A0A2K5VBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:WBP4
gene id: 9541:WBP4
uniprot id: A0A2K5WFB1
names: Subcellular Location Annotation
messages: Nucleus

9541:PPEF1
gene id: 9541:PPEF1
uniprot id: A0A2K5V0C2
uniprot id: A0A8J8Y5I8
uniprot id: Q4R4Y0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9541:CLCF1
gene id: 9541:CLCF1
uniprot id: A0A2K5WX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9541:SLCO1A2
gene id: 9541:SLCO1A2
uniprot id: A0A2K5U5I2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NPPA
gene id: 9541:NPPA
uniprot id: A0A2K5VBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9541:IGHMBP2
gene id: 9541:IGHMBP2
uniprot id: A0A2K5VIR4
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

9541:PAGE3
gene id: 9541:PAGE3
uniprot id: A0A2K5V1E7
uniprot id: A0A7N9ICX2
names: Similarity
messages: Belongs to the GAGE family.

9541:IL12RB2
gene id: 9541:IL12RB2
uniprot id: A0A2K5VNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9541:NDUFA12
gene id: 9541:NDUFA12
uniprot id: A0A2K5TKB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:OGT
gene id: 9541:OGT
uniprot id: A0A2K5TWY1
uniprot id: A0A8J8XT42
uniprot id: G7Q303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9541:NTSR1
gene id: 9541:NTSR1
uniprot id: A0A2K5UQ42
uniprot id: G7PFJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MRPL18
gene id: 9541:MRPL18
uniprot id: I7GLK7
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9541:BECN1
gene id: 9541:BECN1
uniprot id: A0A2K5V236
uniprot id: A0A2K5V238
uniprot id: A0A2K5V263
uniprot id: A0A2K5V2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9541:MEIG1
gene id: 9541:MEIG1
uniprot id: A0A8J8XDF9
uniprot id: G7PEF2
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9541:RIPPLY1
gene id: 9541:RIPPLY1
uniprot id: A0A7N9CJ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9541:NR1D1
gene id: 9541:NR1D1
uniprot id: A0A2K5WKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:ARHGAP12
gene id: 9541:ARHGAP12
uniprot id: Q9BE31
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

9541:CLCN6
gene id: 9541:CLCN6
uniprot id: A0A2K5U8D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:BTG4
gene id: 9541:BTG4
uniprot id: A0A7N9D0K2
names: Similarity
messages: Belongs to the BTG family.

9541:GRIA1
gene id: 9541:GRIA1
uniprot id: A0A7N9D6X7
uniprot id: Q38PU8
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (By similarity). Tetramers may be formed by the dimerization of dimers (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus). Interacts with LRFN1. Interacts with PRKG2. Interacts with CNIH2 and CACNG2. Interacts with CACNG5. Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).
messages: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
messages: Membrane
messages: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
messages: Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).
messages: Postsynaptic cell membrane
messages: Postsynaptic density membrane
messages: Presynapse
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Recycling endosome membrane
messages: Synapse
messages: Synaptic cell membrane
messages: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
messages: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
messages: dendrite
messages: dendritic spine

9541:NT5C3B
gene id: 9541:NT5C3B
uniprot id: A0A2K5U762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9541:FSHR
gene id: 9541:FSHR
uniprot id: P32212
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).
messages: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
messages: Sulfated.

9541:PPT1
gene id: 9541:PPT1
uniprot id: Q8HXW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Glycosylated.
messages: Interacts with CLN5, ATP5F1A and ATP5F1B.
messages: Lysosome
messages: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (By similarity).
messages: Secreted

9541:AMT
gene id: 9541:AMT
uniprot id: A0A2K5WBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:ROPN1B
gene id: 9541:ROPN1B
uniprot id: Q4R6C5
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.
messages: Belongs to the ropporin family.
messages: Homodimer. Interacts with AKAP3 (By similarity). May interact with SPA17 (By similarity). Interacts with RHPN1 (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).
messages: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
messages: Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.
messages: The RIIa domain mediates interaction with AKAP3.
messages: flagellum

9541:METTL26
gene id: 9541:METTL26
uniprot id: A0A2K5UWH8
uniprot id: A0A2K5UWP3
names: Similarity
messages: Belongs to the UPF0585 family.

9541:TRAM2
gene id: 9541:TRAM2
uniprot id: A0A2K5W093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9541:GABRA2
gene id: 9541:GABRA2
uniprot id: A0A2K5WF04
uniprot id: A0A2K5WF28
uniprot id: A0A7N9DDH1
uniprot id: G8F2J4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9541:BAK1
gene id: 9541:BAK1
uniprot id: A0A2K5UMM2
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:EPAS1
gene id: 9541:EPAS1
uniprot id: A0A2K5WDY2
uniprot id: G7PM49
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:SPNS1
gene id: 9541:SPNS1
uniprot id: A0A2K5TUP5
uniprot id: G7Q0T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9541:LOC102119755
gene id: 9541:LOC102119755
uniprot id: A0A7N9D958
names: Similarity
messages: Belongs to the pro/parathymosin family.

9541:HSPB8
gene id: 9541:HSPB8
uniprot id: A0A2K5UDI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9541:NLRP7
gene id: 9541:NLRP7
uniprot id: A0A2K5WBR8
names: Similarity
messages: Belongs to the NLRP family.

9541:DPH1
gene id: 9541:DPH1
uniprot id: A0A7N9CIM9
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9541:CPSF4
gene id: 9541:CPSF4
uniprot id: A0A2K5TTX3
uniprot id: A0A8J8Y521
uniprot id: G7P0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9541:PAX4
gene id: 9541:PAX4
uniprot id: A0A2K5U2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:C4BPB
gene id: 9541:C4BPB
uniprot id: A0A2K5X1I0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:KIF22
gene id: 9541:KIF22
uniprot id: A0A2K5WH65
uniprot id: A0A7N9CVD8
uniprot id: Q4R838
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:PARD3B
gene id: 9541:PARD3B
uniprot id: A0A2K5VK58
uniprot id: A0A2K5VK86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9541:MTHFD1L
gene id: 9541:MTHFD1L
uniprot id: A0A2K5UVG9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9541:LOC102145365
gene id: 9541:LOC102145365
uniprot id: A0A2K5TVZ5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:NFYA
gene id: 9541:NFYA
uniprot id: A0A2K5WQS6
uniprot id: A0A7N9DA59
uniprot id: A0A8J8XVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9541:CCDC126
gene id: 9541:CCDC126
uniprot id: A0A8J8XLQ2
uniprot id: G7P0Q6
uniprot id: I7GKP5
names: Subcellular Location Annotation
messages: Secreted

9541:NR4A1
gene id: 9541:NR4A1
uniprot id: A0A2K5VST3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:LOC102122444
gene id: 9541:LOC102122444
uniprot id: A0A023JBW8
uniprot id: A0A2K5V6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:AVIL
gene id: 9541:AVIL
uniprot id: A0A2K5US22
names: Similarity
messages: Belongs to the villin/gelsolin family.

9541:CABIN1
gene id: 9541:CABIN1
uniprot id: A0A2K5VWI8
uniprot id: A0A2K5VWR9
uniprot id: A0A2K5VWX3
names: Subcellular Location Annotation
messages: Nucleus

9541:BMP5
gene id: 9541:BMP5
uniprot id: A0A2K5UUA8
names: Similarity
messages: Belongs to the TGF-beta family.

9541:LOC102143072
gene id: 9541:LOC102143072
uniprot id: A0A2K5WIA8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:BRI3
gene id: 9541:BRI3
uniprot id: A0A2K5W459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

9541:CYP2U1
gene id: 9541:CYP2U1
uniprot id: A0A2K5WCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:RAMP1
gene id: 9541:RAMP1
uniprot id: A0A2K5V4M1
names: Similarity
messages: Belongs to the RAMP family.

9541:APOBEC3G
gene id: 9541:APOBEC3G
uniprot id: Q05JX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9541:CAMLG
gene id: 9541:CAMLG
uniprot id: I7GK21
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9541:ROR1
gene id: 9541:ROR1
uniprot id: A0A2K5WTX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC102134299
gene id: 9541:LOC102134299
uniprot id: A0A2K5U4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: nucleolus

9541:NME4
gene id: 9541:NME4
uniprot id: A0A2K5UY38
names: Similarity
messages: Belongs to the NDK family.

9541:XRRA1
gene id: 9541:XRRA1
uniprot id: Q95LL2
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed predominantly in testis.
messages: May be involved in the response of cells to X-ray radiation.
messages: Nucleus

9541:RNF157
gene id: 9541:RNF157
uniprot id: A0A2K5UAC7
uniprot id: A0A2K5UAD3
uniprot id: A0A7N9IA45
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9541:BUD23
gene id: 9541:BUD23
uniprot id: A0A2K5W405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9541:LY6H
gene id: 9541:LY6H
uniprot id: Q4R5M8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity).
messages: Cell membrane
messages: Interacts with CHRNA4 and CHRNA7.
messages: It is uncertain whether Met-1 or Met-6 is the initiator.

9541:FAM135B
gene id: 9541:FAM135B
uniprot id: A0A2K5VR07
names: Similarity
messages: Belongs to the FAM135 family.

9541:LOC102131393
gene id: 9541:LOC102131393
uniprot id: A0A2K5X0G8
names: Similarity
messages: Belongs to the IAP family.

9541:CYP26A1
gene id: 9541:CYP26A1
uniprot id: A0A2K5WV20
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:ALG8
gene id: 9541:ALG8
uniprot id: A0A2K5TXV6
uniprot id: A0A2K5TXX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC102141439
gene id: 9541:LOC102141439
uniprot id: A0A2K5U4H8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:FAH
gene id: 9541:FAH
uniprot id: A0A2K5U3A1
names: Similarity
messages: Belongs to the FAH family.

9541:STEAP2
gene id: 9541:STEAP2
uniprot id: A0A2K5VTN5
uniprot id: A0A8J8YG83
uniprot id: G7P1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9541:RIOK1
gene id: 9541:RIOK1
uniprot id: A0A8J8YEB8
uniprot id: G7P4D1
uniprot id: Q4R7J7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9541:POMT2
gene id: 9541:POMT2
uniprot id: A0A2K5VIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9541:AVPR2
gene id: 9541:AVPR2
uniprot id: A0A2K5VHN3
uniprot id: E3VJQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PTPA
gene id: 9541:PTPA
uniprot id: A0A2K5TRN4
uniprot id: A0A2K5TRN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:SUGCT
gene id: 9541:SUGCT
uniprot id: A0A2K5VFL3
names: Similarity
messages: Belongs to the CoA-transferase III family.

9541:ARSB
gene id: 9541:ARSB
uniprot id: A0A2K5WDQ3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:KCTD20
gene id: 9541:KCTD20
uniprot id: A0A2K5V6B5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SCNN1A
gene id: 9541:SCNN1A
uniprot id: A0A2K5VAA2
uniprot id: A0A2K5VAB5
names: Subcellular Location Annotation
messages: Membrane

9541:AMBN
gene id: 9541:AMBN
uniprot id: A0A2K5WK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9541:KRT7
gene id: 9541:KRT7
uniprot id: A0A2K5V4I5
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LTC4S
gene id: 9541:LTC4S
uniprot id: A0A2K5VDB3
uniprot id: A0A7N9D4G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PPARGC1A
gene id: 9541:PPARGC1A
uniprot id: A0A2K5X8F0
uniprot id: A0A2K5X8S3
uniprot id: A0A2K5X8W4
names: Subcellular Location Annotation
messages: PML body

9541:TIMM22
gene id: 9541:TIMM22
uniprot id: A0A2K5UUL3
uniprot id: G7PSY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DDO
gene id: 9541:DDO
uniprot id: A0A2K5TYP1
uniprot id: A0A2K5TYQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9541:MRPS23
gene id: 9541:MRPS23
uniprot id: A0A2K5UX56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9541:MRPL43
gene id: 9541:MRPL43
uniprot id: A0A2K5W456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9541:PSMD9
gene id: 9541:PSMD9
uniprot id: A0A8J8XFE0
uniprot id: G7PJ73
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9541:GGA3
gene id: 9541:GGA3
uniprot id: A0A2K5U969
uniprot id: G7PVD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9541:FAM72A
gene id: 9541:FAM72A
uniprot id: A0A2K5VIA4
uniprot id: A0A8J8XC11
uniprot id: G7NVB7
names: Similarity
messages: Belongs to the FAM72 family.

9541:DBNDD1
gene id: 9541:DBNDD1
uniprot id: A0A2K5WL14
names: Similarity
messages: Belongs to the dysbindin family.

9541:PPP4R3A
gene id: 9541:PPP4R3A
uniprot id: A0A2K5UC38
uniprot id: A0A2K5UC63
names: Similarity
messages: Belongs to the SMEK family.

9541:AP3S1
gene id: 9541:AP3S1
uniprot id: A0A2K5W9E9
uniprot id: A0A2K5W9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9541:ANXA2
gene id: 9541:ANXA2
uniprot id: A0A2K5UQS9
uniprot id: A0A8J8YR13
uniprot id: G7PBL1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9541:GPR6
gene id: 9541:GPR6
uniprot id: G8F545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ALG9
gene id: 9541:ALG9
uniprot id: A0A2K5W0N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CPLANE2
gene id: 9541:CPLANE2
uniprot id: G7NU97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9541:TMX2
gene id: 9541:TMX2
uniprot id: Q4R5B4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Occurs in both reduced and oxidized monomeric form (By similarity). Oxidative conditions increase homodimerization (By similarity). Interacts with CANX (By similarity). Interacts with ATP2A2 (By similarity).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

9541:MEOX2
gene id: 9541:MEOX2
uniprot id: A0A8J8Y4L1
uniprot id: G7P192
names: Subcellular Location Annotation
messages: Nucleus

9541:CDC20
gene id: 9541:CDC20
uniprot id: G7NUW9
uniprot id: Q4R825
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9541:ALG13
gene id: 9541:ALG13
uniprot id: A0A2K5VHX9
uniprot id: A0A2K5VHY6
uniprot id: A0A2K5VHZ5
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9541:TSPAN18
gene id: 9541:TSPAN18
uniprot id: A0A7N9C837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:TARBP2
gene id: 9541:TARBP2
uniprot id: A0A2K5UFU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9541:MED20
gene id: 9541:MED20
uniprot id: Q4R4S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with PPARG (By similarity).
messages: Nucleus

9541:B4GALNT3
gene id: 9541:B4GALNT3
uniprot id: A0A2K5TTZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9541:GHR
gene id: 9541:GHR
uniprot id: A0A2K5WH01
uniprot id: A0A2K5WH03
uniprot id: A0A7N9D090
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9541:ITGA7
gene id: 9541:ITGA7
uniprot id: A0A2K5UN90
uniprot id: A0A2K5UNA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:UBE2E2
gene id: 9541:UBE2E2
uniprot id: A0A2K5TQD0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:VPS8
gene id: 9541:VPS8
uniprot id: A0A2K5VNM1
uniprot id: A0A2K5VNM2
names: Similarity
messages: Belongs to the VPS8 family.

9541:GOT2
gene id: 9541:GOT2
uniprot id: Q4R559
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
messages: Cell membrane
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

9541:MMP1
gene id: 9541:MMP1
uniprot id: A0A8J8XTD3
uniprot id: G7PNK5
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:QRSL1
gene id: 9541:QRSL1
uniprot id: Q4R7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9541:ELOF1
gene id: 9541:ELOF1
uniprot id: A0A2K5VJK5
uniprot id: G7PZF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9541:HESX1
gene id: 9541:HESX1
uniprot id: A0A2K5WCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9541:AMOTL2
gene id: 9541:AMOTL2
uniprot id: A0A2K5U227
names: Similarity
messages: Belongs to the angiomotin family.

9541:LOC102134028
gene id: 9541:LOC102134028
uniprot id: A0A2K5VS49
uniprot id: A0A7N9CRH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9541:SLC2A6
gene id: 9541:SLC2A6
uniprot id: A0A2K5TNB1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9541:PPP2R2A
gene id: 9541:PPP2R2A
uniprot id: A0A805QTE8
uniprot id: Q4R7Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity). Interacts with MFHAS1; the interaction is direct (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with CRTC3 (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.

9541:SKA2
gene id: 9541:SKA2
uniprot id: Q4R8E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA2 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
messages: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1 in vivo (By similarity).
messages: kinetochore
messages: spindle

9541:RUSF1
gene id: 9541:RUSF1
uniprot id: A0A2K5V1R9
names: Similarity
messages: Belongs to the RUS1 family.

9541:CTNNAL1
gene id: 9541:CTNNAL1
uniprot id: A0A2K5UHR8
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9541:MTMR12
gene id: 9541:MTMR12
uniprot id: A0A2K5WJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9541:TMEM176B
gene id: 9541:TMEM176B
uniprot id: A0A2K5VMI1
uniprot id: A0A2K5VMR3
uniprot id: G7P208
names: Similarity
messages: Belongs to the TMEM176 family.

9541:PPP1R14C
gene id: 9541:PPP1R14C
uniprot id: A0A2K5TWB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9541:PRRT1
gene id: 9541:PRRT1
uniprot id: A0A2K5UZD2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:MTNR1A
gene id: 9541:MTNR1A
uniprot id: C9WTA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9541:MRPS18A
gene id: 9541:MRPS18A
uniprot id: A0A2K5TSW2
names: Subcellular Location Annotation
messages: Mitochondrion

9541:MBL2
gene id: 9541:MBL2
uniprot id: A0A2K5UZY9
uniprot id: G7PDG1
uniprot id: Q66S50
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

9541:SLC7A3
gene id: 9541:SLC7A3
uniprot id: A0A2K5U070
uniprot id: G7Q2Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:URAD
gene id: 9541:URAD
uniprot id: A0A2K5VFU0
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9541:NATD1
gene id: 9541:NATD1
uniprot id: A0A7N9C8E1
names: Similarity
messages: Belongs to the NATD1 family.

9541:ITGAD
gene id: 9541:ITGAD
uniprot id: A0A2K5TKB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:DCTN1
gene id: 9541:DCTN1
uniprot id: A0A2K5TMT3
uniprot id: A0A2K5TMV2
uniprot id: A0A2K5TMV3
uniprot id: G7PMI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9541:SARDH
gene id: 9541:SARDH
uniprot id: A0A2K5WMP9
names: Similarity
messages: Belongs to the GcvT family.

9541:CAPRIN2
gene id: 9541:CAPRIN2
uniprot id: A0A2K5UJU5
names: Similarity
messages: Belongs to the caprin family.

9541:DYNLT2B
gene id: 9541:DYNLT2B
uniprot id: A0A2K5V5S9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9541:DVL2
gene id: 9541:DVL2
uniprot id: A0A2K5X5M5
names: Similarity
messages: Belongs to the DSH family.

9541:CTU2
gene id: 9541:CTU2
uniprot id: A0A2K5USQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9541:GDA
gene id: 9541:GDA
uniprot id: A0A2K5V8Q6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9541:GRM4
gene id: 9541:GRM4
uniprot id: A0A2K5VGS8
uniprot id: A0A2K5VGV9
uniprot id: A0A2K5VGY0
uniprot id: Q1ZZH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity).
messages: Interacts with PICK1.
messages: Membrane

9541:HAGH
gene id: 9541:HAGH
uniprot id: A0A2K5WE54
uniprot id: Q4R6C1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1. Alternative initiation has been proven in human.
messages: Testis.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

9541:EIF4E
gene id: 9541:EIF4E
uniprot id: A0A2K5WU54
uniprot id: A0A2K5WU58
uniprot id: I7GAS4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9541:EXOC2
gene id: 9541:EXOC2
uniprot id: A0A2K5VSX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9541:SERINC1
gene id: 9541:SERINC1
uniprot id: A0A8J8Y6V0
uniprot id: G7P394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:AMIGO1
gene id: 9541:AMIGO1
uniprot id: A0A8J8XXM3
uniprot id: G7NV59
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9541:PDE7A
gene id: 9541:PDE7A
uniprot id: A0A2K5WGM8
uniprot id: A0A8J8XNN1
uniprot id: G7PBY0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:SLC6A3
gene id: 9541:SLC6A3
uniprot id: A9XCH4
uniprot id: Q9GJT6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (By similarity). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Mediates sodium- and chloride-dependent transport of dopamine (By similarity). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
messages: Membrane
messages: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
messages: axon
messages: neuron projection

9541:EMSY
gene id: 9541:EMSY
uniprot id: A0A2K5VWJ6
uniprot id: A0A2K5VWP7
uniprot id: A0A2K5VWT6
uniprot id: A0A8J8YMX9
uniprot id: G7PNA3
names: Subcellular Location Annotation
messages: Nucleus

9541:KDM5A
gene id: 9541:KDM5A
uniprot id: A0A2K5TWE4
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9541:MLST8
gene id: 9541:MLST8
uniprot id: A0A2K5VVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9541:LOC102138563
gene id: 9541:LOC102138563
uniprot id: A0A2K5V122
names: Similarity
messages: Belongs to the PRAME family.

9541:LOC102140088
gene id: 9541:LOC102140088
uniprot id: A0A2K5V684
names: Similarity
messages: Belongs to the strictosidine synthase family.

9541:PRELID3B
gene id: 9541:PRELID3B
uniprot id: Q4R5S9
names: Similarity
messages: Belongs to the slowmo family.

9541:LOC102129301
gene id: 9541:LOC102129301
uniprot id: A0A2K5UMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CHAT
gene id: 9541:CHAT
uniprot id: A0A2K5VTI9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9541:IFNG
gene id: 9541:IFNG
uniprot id: G7PHZ5
uniprot id: P63309
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9541:OAZ2
gene id: 9541:OAZ2
uniprot id: A0A2K5UAI7
names: Similarity
messages: Belongs to the ODC antizyme family.

9541:SGCD
gene id: 9541:SGCD
uniprot id: A0A2K5UZX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9541:ANXA1
gene id: 9541:ANXA1
uniprot id: A0A2K5W030
uniprot id: G7PSJ7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9541:TMEM87A
gene id: 9541:TMEM87A
uniprot id: A0A2K5WC65
uniprot id: A0A8J8XB06
uniprot id: G7PB00
uniprot id: I7GDS0
names: Subcellular Location Annotation
messages: Membrane

9541:ETV3
gene id: 9541:ETV3
uniprot id: A0A2K5TUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

9541:LOC102144852
gene id: 9541:LOC102144852
uniprot id: A0A2K5WG23
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9541:MED23
gene id: 9541:MED23
uniprot id: A0A2K5UEW8
uniprot id: A0A2K5UEX8
uniprot id: G7P359
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9541:TTC39A
gene id: 9541:TTC39A
uniprot id: A0A2K5WJ05
uniprot id: A0A2K5WJ45
names: Similarity
messages: Belongs to the TTC39 family.

9541:H1-4
gene id: 9541:H1-4
uniprot id: A0A8J8Y8N7
uniprot id: G7P2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:GALNT7
gene id: 9541:GALNT7
uniprot id: A0A2K5X1R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:CDKN1B
gene id: 9541:CDKN1B
uniprot id: A0A2K5V146
uniprot id: G7PJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9541:RPL24
gene id: 9541:RPL24
uniprot id: P61122
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.

9541:MYH3
gene id: 9541:MYH3
uniprot id: A0A2K5UCX9
uniprot id: A0A2K5UD03
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:LOC102125955
gene id: 9541:LOC102125955
uniprot id: A0A2K5W0B7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:IL16
gene id: 9541:IL16
uniprot id: A0A2K5UZL5
uniprot id: A0A2K5UZN3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9541:CHDH
gene id: 9541:CHDH
uniprot id: A0A2K5U1B5
uniprot id: G7NZU2
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9541:LOC102138137
gene id: 9541:LOC102138137
uniprot id: G7P2L9
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:TADA1
gene id: 9541:TADA1
uniprot id: A0A8J8Y822
uniprot id: G7NU37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9541:ADRB2
gene id: 9541:ADRB2
uniprot id: A0A2K5UI86
uniprot id: G7P8M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Membrane

9541:LOC102118616
gene id: 9541:LOC102118616
uniprot id: A0A2K5UGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PYROXD1
gene id: 9541:PYROXD1
uniprot id: A0A2K5UA44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9541:SUPT3H
gene id: 9541:SUPT3H
uniprot id: A0A2K5UI13
names: Subcellular Location Annotation
messages: Nucleus

9541:PFDN2
gene id: 9541:PFDN2
uniprot id: A0A2K5V9W8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9541:LOC102122418
gene id: 9541:LOC102122418
uniprot id: A0A2K5U3G2
uniprot id: G7Q2H9
names: Subcellular Location Annotation
messages: Membrane

9541:SAMD4A
gene id: 9541:SAMD4A
uniprot id: A0A2K5VV40
uniprot id: A0A2K5VVG8
uniprot id: Q95LV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a translational repressor of SRE-containing messengers.
messages: Belongs to the SMAUG family.
messages: Cytoplasm
messages: dendrite
messages: synaptosome

9541:IPO5
gene id: 9541:IPO5
uniprot id: A0A2K5U190
uniprot id: Q4R8T7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:MOCS1
gene id: 9541:MOCS1
uniprot id: A0A2K5URB1
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9541:LIX1
gene id: 9541:LIX1
uniprot id: A0A2K5U7H8
names: Similarity
messages: Belongs to the LIX1 family.

9541:PPP1R3C
gene id: 9541:PPP1R3C
uniprot id: A0A2K5X6W1
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9541:FAM229B
gene id: 9541:FAM229B
uniprot id: A5LFY3
uniprot id: G7P3M5
names: Similarity
messages: Belongs to the FAM229 family.

9541:ZNF326
gene id: 9541:ZNF326
uniprot id: A0A2K5VLL0
names: Similarity
messages: Belongs to the AKAP95 family.

9541:AKTIP
gene id: 9541:AKTIP
uniprot id: Q4R5E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A.
messages: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.

9541:PSMA7
gene id: 9541:PSMA7
uniprot id: A0A2K5X9B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:HSPH1
gene id: 9541:HSPH1
uniprot id: A0A2K5UIW1
uniprot id: A0A2K5UIX0
uniprot id: A0A7N9CYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9541:GAL3ST1
gene id: 9541:GAL3ST1
uniprot id: A0A2K5UPT1
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9541:SLC20A2
gene id: 9541:SLC20A2
uniprot id: A0A2K5UAN6
uniprot id: G7PBR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9541:LOC102142503
gene id: 9541:LOC102142503
uniprot id: G7NZE1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9541:MLEC
gene id: 9541:MLEC
uniprot id: A0A2K5UV44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TENM1
gene id: 9541:TENM1
uniprot id: A0A2K5U2F0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SEZ6
gene id: 9541:SEZ6
uniprot id: A0A2K5WPJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:YPEL4
gene id: 9541:YPEL4
uniprot id: G7PQ32
uniprot id: Q25NF5
names: Similarity
messages: Belongs to the yippee family.

9541:PRSS12
gene id: 9541:PRSS12
uniprot id: A0A2K5UTZ6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9541:SUGT1
gene id: 9541:SUGT1
uniprot id: A0A2K5VAP2
names: Similarity
messages: Belongs to the SGT1 family.

9541:RRP1
gene id: 9541:RRP1
uniprot id: A0A2K5W8E3
names: Similarity
messages: Belongs to the RRP1 family.

9541:HNF4A
gene id: 9541:HNF4A
uniprot id: A0A2K5VA24
uniprot id: A0A2K5VA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:CPA4
gene id: 9541:CPA4
uniprot id: A0A2K5X0D2
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:YPEL2
gene id: 9541:YPEL2
uniprot id: A0A2K5WCK4
names: Similarity
messages: Belongs to the yippee family.

9541:LOC102127391
gene id: 9541:LOC102127391
uniprot id: A0A2K5UCG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:HAPLN3
gene id: 9541:HAPLN3
uniprot id: A0A2K5X326
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:HMGA1
gene id: 9541:HMGA1
uniprot id: I7GET7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
messages: Interacts with HIPK2.
messages: Nucleus

9541:SPTA1
gene id: 9541:SPTA1
uniprot id: A0A2K5UN69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9541:SERPINA4
gene id: 9541:SERPINA4
uniprot id: A0A2K5UHF8
names: Similarity
messages: Belongs to the serpin family.

9541:OSBPL6
gene id: 9541:OSBPL6
uniprot id: A0A2K5WF67
uniprot id: A0A2K5WF71
uniprot id: A0A2K5WF76
uniprot id: A0A2K5WFF0
uniprot id: A0A8J8YEW8
uniprot id: G7PKX7
names: Similarity
messages: Belongs to the OSBP family.

9541:SLC25A31
gene id: 9541:SLC25A31
uniprot id: G7P691
uniprot id: Q4R8M0
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
messages: flagellum membrane

9541:NID1
gene id: 9541:NID1
uniprot id: A0A2K5UK97
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9541:RRAGA
gene id: 9541:RRAGA
uniprot id: I7G5F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9541:ANAPC5
gene id: 9541:ANAPC5
uniprot id: A0A2K5U3D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9541:GRM3
gene id: 9541:GRM3
uniprot id: A0A8J8XYC3
uniprot id: G7P1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9541:TGIF1
gene id: 9541:TGIF1
uniprot id: A0A2K5W8Q8
uniprot id: I7GDB5
names: Subcellular Location Annotation
messages: Nucleus

9541:FFAR1
gene id: 9541:FFAR1
uniprot id: Q76JV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.

9541:KCNG4
gene id: 9541:KCNG4
uniprot id: A0A2K5VKK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:SLC18A3
gene id: 9541:SLC18A3
uniprot id: A0A2K5UE16
names: Subcellular Location Annotation
messages: Membrane

9541:RNF125
gene id: 9541:RNF125
uniprot id: Q95KF1
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, leading to its subsequent proteasomal degradation.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
messages: Golgi apparatus membrane
messages: Interacts with UBE2D1. Interacts with VCP/p97; leading to recruit RNF125 to RIGI and promote ubiquitination of RIGI.
messages: The C2HC RNF-type zinc finger and the linker region stabilize the RING-type zinc finger, leading to promote binding of the RING-type zinc finger to the ubiquitin-conjugating enzyme E2 (donor ubiquitin).

9541:RFC5
gene id: 9541:RFC5
uniprot id: A0A2K5VKM6
uniprot id: G8F2Q2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9541:EMC7
gene id: 9541:EMC7
uniprot id: G7PAN8
uniprot id: Q4R5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

9541:CCDC96
gene id: 9541:CCDC96
uniprot id: Q95LS7
names: Subcellular Location Annotation
messages: centrosome

9541:CA4
gene id: 9541:CA4
uniprot id: A0A2K5V3L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

9541:RIC3
gene id: 9541:RIC3
uniprot id: G7PQS9
names: Similarity
messages: Belongs to the ric-3 family.

9541:SAR1A
gene id: 9541:SAR1A
uniprot id: A0A2K5WYE8
uniprot id: G7PF44
uniprot id: I7GKR3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9541:AUH
gene id: 9541:AUH
uniprot id: A0A2K5WCU2
uniprot id: A0A2K5WCX1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:HECTD2
gene id: 9541:HECTD2
uniprot id: A0A2K5UGR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RPL37
gene id: 9541:RPL37
uniprot id: A0A7N9IBE1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9541:TLCD1
gene id: 9541:TLCD1
uniprot id: A0A2K5W4Y4
uniprot id: A0A2K5W538
names: Subcellular Location Annotation
messages: Membrane

9541:FAXDC2
gene id: 9541:FAXDC2
uniprot id: Q9GKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Cytoplasm
messages: Membrane
messages: Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.

9541:ALAS2
gene id: 9541:ALAS2
uniprot id: A0A2K5W9X2
uniprot id: A0A2K5WA41
uniprot id: G7Q2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9541:PGM2
gene id: 9541:PGM2
uniprot id: A0A2K5WE15
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9541:ZNF483
gene id: 9541:ZNF483
uniprot id: A0A2K5UVJ3
uniprot id: G8F3G3
names: Subcellular Location Annotation
messages: Nucleus

9541:REN
gene id: 9541:REN
uniprot id: A0A2K5U9N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9541:SLC15A1
gene id: 9541:SLC15A1
uniprot id: A0A2K5UCX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9541:ZNF277
gene id: 9541:ZNF277
uniprot id: A0A2K5U610
uniprot id: G7P2H1
names: Similarity
messages: Belongs to the ZNF277 family.

9541:ZNF668
gene id: 9541:ZNF668
uniprot id: Q4R3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:ADGRV1
gene id: 9541:ADGRV1
uniprot id: A0A2K5V3R1
names: Subcellular Location Annotation
messages: Membrane

9541:COL4A4
gene id: 9541:COL4A4
uniprot id: A0A2K5X8K5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9541:PIGN
gene id: 9541:PIGN
uniprot id: A0A2K5VN51
uniprot id: G7PWW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9541:UPRT
gene id: 9541:UPRT
uniprot id: Q95KB0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPRTase family.
messages: Cytoplasm
messages: Nucleus
messages: The uracil binding region known from UPRTases is missing.

9541:HSPB3
gene id: 9541:HSPB3
uniprot id: A0A2K5UR85
uniprot id: G7P7H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9541:MDFI
gene id: 9541:MDFI
uniprot id: A0A2K5UCB9
names: Similarity
messages: Belongs to the MDFI family.

9541:SSR4
gene id: 9541:SSR4
uniprot id: A0A8J8XAD8
uniprot id: G7Q200
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9541:MMP19
gene id: 9541:MMP19
uniprot id: A0A2K5U112
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:IFI6
gene id: 9541:IFI6
uniprot id: Q25Q84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9541:SGCA
gene id: 9541:SGCA
uniprot id: A0A2K5UMZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton

9541:EIF3F
gene id: 9541:EIF3F
uniprot id: Q4R5B8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1 (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
messages: Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11 (By similarity).
messages: The MPN domain mediates deubiquitinating activity.

9541:MACO1
gene id: 9541:MACO1
uniprot id: A0A2K5X0M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9541:BICC1
gene id: 9541:BICC1
uniprot id: A0A2K5WQC8
uniprot id: A0A2K5WQN6
names: Similarity
messages: Belongs to the BicC family.

9541:ASB6
gene id: 9541:ASB6
uniprot id: A0A2K5UDT3
uniprot id: A0A2K5UDT7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:MYCN
gene id: 9541:MYCN
uniprot id: A0A2K5V4C0
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9541:NCALD
gene id: 9541:NCALD
uniprot id: Q4R4N4
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

9541:RIOK2
gene id: 9541:RIOK2
uniprot id: A0A2K5V606
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9541:SLC39A12
gene id: 9541:SLC39A12
uniprot id: A0A2K5TNC0
uniprot id: Q95KA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a zinc-influx transporter.
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9541:TAS2R16
gene id: 9541:TAS2R16
uniprot id: A0A7N9CVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:LOC102118468
gene id: 9541:LOC102118468
uniprot id: A0A2K5UJ55
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9541:LOC102125835
gene id: 9541:LOC102125835
uniprot id: A0A2K5VQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9541:LOC102131403
gene id: 9541:LOC102131403
uniprot id: A0A7N9CW39
names: Similarity
messages: Belongs to the SNF7 family.

9541:B2M
gene id: 9541:B2M
uniprot id: I7GKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9541:PHKA1
gene id: 9541:PHKA1
uniprot id: A0A2K5WQ96
uniprot id: A0A2K5WQA7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9541:TRABD2B
gene id: 9541:TRABD2B
uniprot id: A0A2K5WCM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9541:COPB2
gene id: 9541:COPB2
uniprot id: Q4R4I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1. Interacts with JAGN1 (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity).
messages: cytosol

9541:LOC102123076
gene id: 9541:LOC102123076
uniprot id: A0A2K5TSZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9541:UROC1
gene id: 9541:UROC1
uniprot id: A0A2K5VZ18
names: Similarity
messages: Belongs to the urocanase family.

9541:DAND5
gene id: 9541:DAND5
uniprot id: A0A2K5X611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9541:LHFPL2
gene id: 9541:LHFPL2
uniprot id: A0A2K5W3H9
names: Subcellular Location Annotation
messages: Membrane

9541:DHX15
gene id: 9541:DHX15
uniprot id: A0A2K5WB33
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9541:LOC102119972
gene id: 9541:LOC102119972
uniprot id: I7GNA2
names: Similarity
messages: Belongs to the cytochrome b5 family.

9541:KEG98 p12
gene id: 9541:KEG98_p12
uniprot id: C3W4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PARL
gene id: 9541:PARL
uniprot id: I7GIY6
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102133631
gene id: 9541:LOC102133631
uniprot id: A0A7N9CTH0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9541:YDJC
gene id: 9541:YDJC
uniprot id: A0A2K5WWD4
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9541:EFS
gene id: 9541:EFS
uniprot id: A0A2K5TRI6
uniprot id: A0A7N9D1U2
names: Similarity
messages: Belongs to the CAS family.

9541:ELMO1
gene id: 9541:ELMO1
uniprot id: A0A2K5TXT1
uniprot id: A0A2K5TXT2
uniprot id: A0A7N9CBV5
uniprot id: A0A7N9CBY5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9541:CAB39L
gene id: 9541:CAB39L
uniprot id: A0A8J8XN18
uniprot id: G7PVE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9541:CLTC
gene id: 9541:CLTC
uniprot id: A0A2K5X3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9541:SCN3A
gene id: 9541:SCN3A
uniprot id: A0A2K5VS58
uniprot id: A0A2K5VS92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:LOC102125303
gene id: 9541:LOC102125303
uniprot id: A0A2K5U974
uniprot id: A0A2K5U979
uniprot id: A0A2K5U980
names: Similarity
messages: Belongs to the villin/gelsolin family.

9541:RFFL
gene id: 9541:RFFL
uniprot id: A0A2K5TJB7
names: Subcellular Location Annotation
messages: Cell membrane

9541:MRPS18C
gene id: 9541:MRPS18C
uniprot id: A0A2K5WDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9541:LOC102143999
gene id: 9541:LOC102143999
uniprot id: A0A2K5TK21
uniprot id: A0A2K5TK66
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9541:MAU2
gene id: 9541:MAU2
uniprot id: A0A2K5VWV5
uniprot id: A0A2K5VWW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9541:LOC102139511
gene id: 9541:LOC102139511
uniprot id: A0A2K5UP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:NAE1
gene id: 9541:NAE1
uniprot id: Q2PFN1
uniprot id: Q4R3L6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.
messages: Cell membrane
messages: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2 (By similarity).
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity).
messages: Ubiquitinated by TRIP12, leading to its degradation by the proteasome.

9541:AKT3
gene id: 9541:AKT3
uniprot id: A0A2K5V8I8
uniprot id: A0A2K5V8J4
uniprot id: A0A7N9CEN6
uniprot id: A0A7N9IGM4
uniprot id: A0A8J8YC63
uniprot id: G7NWL3
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9541:MRPS21
gene id: 9541:MRPS21
uniprot id: A0A8J8Y104
uniprot id: G7NTS9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9541:POLR3A
gene id: 9541:POLR3A
uniprot id: A0A8J8YMI0
uniprot id: G7PEY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9541:CDH7
gene id: 9541:CDH7
uniprot id: A0A8J8YM50
uniprot id: G7PW74
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:NLRP14
gene id: 9541:NLRP14
uniprot id: A0A2K5UP25
names: Similarity
messages: Belongs to the NLRP family.

9541:ZDHHC12
gene id: 9541:ZDHHC12
uniprot id: A0A2K5TZA4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CLU
gene id: 9541:CLU
uniprot id: A0A2K5VV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9541:IAH1
gene id: 9541:IAH1
uniprot id: A0A2K5TPY2
uniprot id: A0A7N9DFY3
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9541:SLC16A4
gene id: 9541:SLC16A4
uniprot id: A0A2K5WWK4
uniprot id: A0A2K5WWT1
names: Subcellular Location Annotation
messages: Membrane

9541:DDI2
gene id: 9541:DDI2
uniprot id: A0A2K5WZ37
names: Similarity
messages: Belongs to the DDI1 family.

9541:LOC102126587
gene id: 9541:LOC102126587
uniprot id: A0A2K5TJ91
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:ATRX
gene id: 9541:ATRX
uniprot id: A0A2K5V081
uniprot id: A0A2K5V0F0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9541:ARHGEF12
gene id: 9541:ARHGEF12
uniprot id: A0A2K5TU65
uniprot id: A0A2K5TU72
uniprot id: A0A2K5TU81
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9541:GIPR
gene id: 9541:GIPR
uniprot id: A0A2K5VD75
names: Subcellular Location Annotation
messages: Membrane

9541:ISCU
gene id: 9541:ISCU
uniprot id: I7GEK8
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9541:LOC102120741
gene id: 9541:LOC102120741
uniprot id: G7P2L6
uniprot id: G7P2M7
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:BRS3
gene id: 9541:BRS3
uniprot id: A0A2K5TT26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9541:SLC9A9
gene id: 9541:SLC9A9
uniprot id: A0A8J8YKJ7
uniprot id: G7P004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9541:TCTN3
gene id: 9541:TCTN3
uniprot id: Q4R9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tectonic family.
messages: Membrane
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway (By similarity).

9541:ACTR3
gene id: 9541:ACTR3
uniprot id: A0A2K5WY73
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9541:FAM187A
gene id: 9541:FAM187A
uniprot id: A0A8J8YDG6
uniprot id: G7PV11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9541:UBE2D3
gene id: 9541:UBE2D3
uniprot id: A0A2K5W7V3
uniprot id: A0A2K5W840
uniprot id: I7GL84
uniprot id: Q4R5N4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cell membrane
messages: Endosome membrane
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).
messages: Phosphorylated by AURKB.

9541:GPR89A
gene id: 9541:GPR89A
uniprot id: A0A2K5U8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9541:SLC20A1
gene id: 9541:SLC20A1
uniprot id: A0A2K5UD48
uniprot id: A0A7N9DB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9541:AMD1
gene id: 9541:AMD1
uniprot id: A0A2K5UT80
uniprot id: G7P3N5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9541:TACR3
gene id: 9541:TACR3
uniprot id: A0A2K5X9Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:AFF2
gene id: 9541:AFF2
uniprot id: A0A2K5VQ96
names: Similarity
messages: Belongs to the AF4 family.

9541:LOC102129503
gene id: 9541:LOC102129503
uniprot id: G7PCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:NRF1
gene id: 9541:NRF1
uniprot id: A0A2K5VBZ1
uniprot id: A0A2K5VC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9541:WDR24
gene id: 9541:WDR24
uniprot id: A0A2K5UV49
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

9541:SUCLA2
gene id: 9541:SUCLA2
uniprot id: Q4R517
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP. Interacts with ALAS2 (By similarity).
messages: Mitochondrion

9541:SCUBE3
gene id: 9541:SCUBE3
uniprot id: A0A2K5UK84
uniprot id: A0A2K5VBW0
uniprot id: A0A7N9DF80
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:HTATSF1
gene id: 9541:HTATSF1
uniprot id: A0A2K5VP69
names: Similarity
messages: Belongs to the HTATSF1 family.

9541:CACNG4
gene id: 9541:CACNG4
uniprot id: A0A2K5VDF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9541:LOC102117900
gene id: 9541:LOC102117900
uniprot id: D3GG13
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9541:TMED9
gene id: 9541:TMED9
uniprot id: I7GHY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102138114
gene id: 9541:LOC102138114
uniprot id: A0A2K5VQK2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9541:HDAC11
gene id: 9541:HDAC11
uniprot id: Q9GKU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family.
messages: Interacts with HDAC6.
messages: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

9541:KBTBD8
gene id: 9541:KBTBD8
uniprot id: A0A2K5WA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9541:MAP2
gene id: 9541:MAP2
uniprot id: A0A2K5W6F5
uniprot id: A0A2K5W6J2
uniprot id: A0A2K5W6L6
uniprot id: A0A7N9DEN1
uniprot id: G7PLB5
names: Subcellular Location Annotation
messages: cytoskeleton

9541:LOC102117168
gene id: 9541:LOC102117168
uniprot id: G7PS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:AK5
gene id: 9541:AK5
uniprot id: A0A2K5VF31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9541:FGD1
gene id: 9541:FGD1
uniprot id: A0A2K5UBT3
names: Subcellular Location Annotation
messages: cytoskeleton

9541:BACE2
gene id: 9541:BACE2
uniprot id: A0A2K5V1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Secreted

9541:ATP6V1B1
gene id: 9541:ATP6V1B1
uniprot id: A0A8J8XV71
uniprot id: G7PMF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9541:SUOX
gene id: 9541:SUOX
uniprot id: A0A2K5WYK3
uniprot id: Q60HD0
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.
messages: Mitochondrion intermembrane space

9541:SLC13A5
gene id: 9541:SLC13A5
uniprot id: A0A8J8Y478
uniprot id: G7PTE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:SIGIRR
gene id: 9541:SIGIRR
uniprot id: A0A2K5WX31
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:SETDB1
gene id: 9541:SETDB1
uniprot id: A0A2K5VZX6
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9541:GPKOW
gene id: 9541:GPKOW
uniprot id: A0A8J8XSZ1
uniprot id: G7Q2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9541:GOLGA5
gene id: 9541:GOLGA5
uniprot id: A0A2K5TVH1
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9541:TAF11
gene id: 9541:TAF11
uniprot id: A0A2K5VAH3
uniprot id: G7P2U5
names: Similarity
messages: Belongs to the TAF11 family.

9541:TOP2A
gene id: 9541:TOP2A
uniprot id: A0A2K5TYT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9541:EFHC1
gene id: 9541:EFHC1
uniprot id: A0A2K5TJ25
names: Subcellular Location Annotation
messages: cilium axoneme

9541:SLC30A9
gene id: 9541:SLC30A9
uniprot id: G7P5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

9541:ATP2B2
gene id: 9541:ATP2B2
uniprot id: A0A2K5U4V9
uniprot id: A0A2K5U4W6
uniprot id: A0A2K5U4Y2
uniprot id: A0A2K5U4Y5
uniprot id: A0A2K5U535
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:AZIN1
gene id: 9541:AZIN1
uniprot id: A0A2K5WZB4
uniprot id: I7GIW1
uniprot id: I7GJ97
uniprot id: I7GMJ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9541:YWHAE
gene id: 9541:YWHAE
uniprot id: A0A2K5WWZ6
uniprot id: A0A2K5WX26
uniprot id: Q4R4J3
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:LOC102128132
gene id: 9541:LOC102128132
uniprot id: A0A8J8YPI1
uniprot id: G7P1L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:LOC102126880
gene id: 9541:LOC102126880
uniprot id: A0A2K5ULT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102124177
gene id: 9541:LOC102124177
uniprot id: A0A2K5U6K9
uniprot id: A0A2K5VLR8
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9541:TUBGCP5
gene id: 9541:TUBGCP5
uniprot id: A0A2K5UYW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9541:BPI
gene id: 9541:BPI
uniprot id: A0A2K5VAG2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9541:ACAT2
gene id: 9541:ACAT2
uniprot id: A0A2K5V9T2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9541:ADAMTS2
gene id: 9541:ADAMTS2
uniprot id: A0A2K5W612
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:PDHB
gene id: 9541:PDHB
uniprot id: A0A2K5V5K5
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9541:ACER2
gene id: 9541:ACER2
uniprot id: A0A8J8Y0D7
uniprot id: G7PSA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:RPS6KB2
gene id: 9541:RPS6KB2
uniprot id: A0A2K5UWA4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:PRPS1L1
gene id: 9541:PRPS1L1
uniprot id: A0A7N9CH96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9541:CEBPZ
gene id: 9541:CEBPZ
uniprot id: A0A2K5W129
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9541:ORC1
gene id: 9541:ORC1
uniprot id: A0A2K5TSF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

9541:LOC102122694
gene id: 9541:LOC102122694
uniprot id: A0A2K5W1V6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9541:ACKR4
gene id: 9541:ACKR4
uniprot id: A0A8J8Y5K1
uniprot id: G7NXZ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:USP22
gene id: 9541:USP22
uniprot id: A0A2K5X8G9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:GGA1
gene id: 9541:GGA1
uniprot id: A0A2K5VLK7
uniprot id: A0A2K5VLN3
uniprot id: A0A2K5VLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9541:DNAJA4
gene id: 9541:DNAJA4
uniprot id: A0A2K5UTB4
names: Subcellular Location Annotation
messages: Membrane

9541:UBQLN2
gene id: 9541:UBQLN2
uniprot id: G8F2K6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9541:PRKCG
gene id: 9541:PRKCG
uniprot id: Q4R4U2
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-…
messages: Cell membrane
messages: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.
messages: Cytoplasm
messages: Interacts with CDCP1 and GRIA4. Interacts with TP53INP1 and p53/TP53. Interacts with BMAL1.
messages: Ubiquitinated.
messages: dendrite
messages: perinuclear region
messages: synaptosome

9541:GFRA4
gene id: 9541:GFRA4
uniprot id: A0A2K5X1I7
names: Similarity
messages: Belongs to the GDNFR family.

9541:SRP9
gene id: 9541:SRP9
uniprot id: G8F5S9
uniprot id: Q4R6I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).

9541:MSANTD3
gene id: 9541:MSANTD3
uniprot id: A0A8J8Y9T4
uniprot id: G7PRU2
names: Similarity
messages: Belongs to the MSANTD3 family.

9541:EHD2
gene id: 9541:EHD2
uniprot id: Q4R9B5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9541:BCL9
gene id: 9541:BCL9
uniprot id: A0A2K5VHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9541:LOC102117303
gene id: 9541:LOC102117303
uniprot id: A0A7N9CI04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9541:CCDC181
gene id: 9541:CCDC181
uniprot id: A0A2K5WVE0
uniprot id: Q4R6Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC181 family.
messages: Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9541:LOC107127356
gene id: 9541:LOC107127356
uniprot id: G7PQ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:POLR2F
gene id: 9541:POLR2F
uniprot id: A0A2K5U2B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9541:TMEM41B
gene id: 9541:TMEM41B
uniprot id: A0A2K5W756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9541:YIPF6
gene id: 9541:YIPF6
uniprot id: A0A8J8XVC8
uniprot id: G7Q2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9541:S100A10
gene id: 9541:S100A10
uniprot id: A0A2K5VQE4
uniprot id: G7NTU2
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9541:KAT6A
gene id: 9541:KAT6A
uniprot id: A0A2K5X204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9541:HUS1
gene id: 9541:HUS1
uniprot id: A0A2K5U6G8
names: Similarity
messages: Belongs to the HUS1 family.

9541:AP1B1
gene id: 9541:AP1B1
uniprot id: A0A2K5X0N0
uniprot id: A0A2K5X0Q6
uniprot id: A0A2K5X187
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9541:GJA1
gene id: 9541:GJA1
uniprot id: Q4R4S7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65 (By similarity).
messages: Acetylated in the developing cortex; leading to delocalization from the cell membrane.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
messages: Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).
messages: S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.
messages: Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).
messages: gap junction

9541:THADA
gene id: 9541:THADA
uniprot id: A0A2K5UJK6
names: Similarity
messages: Belongs to the THADA family.

9541:MRE11
gene id: 9541:MRE11
uniprot id: A0A2K5X3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9541:BCAR3
gene id: 9541:BCAR3
uniprot id: Q4R8R1
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).
messages: Cytoplasm
messages: Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (By similarity). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-798') (By similarity). Interacts (via Ras-GEF domain) with BCAR1 (By similarity). Interacts (via Ras-GEF domain) with NEDD9 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PTPN1. Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (By similarity).
messages: Phosphorylated on tyrosine residues.
messages: The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.
messages: The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (By similarity). However, not involved in the binding to phosphorylated BCAR1 (By similarity). Required for cell cycle progression in response to INS/insulin (By similarity). Required for regulation of EGF-induced DNA synthesis (By similarity).
messages: The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (By similarity). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (By similarity).
messages: focal adhesion

9541:UNC5D
gene id: 9541:UNC5D
uniprot id: A0A2K5X484
uniprot id: A0A2K5X486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9541:CREB5
gene id: 9541:CREB5
uniprot id: A0A2K5TR28
uniprot id: A0A2K5TR43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9541:IDH3G
gene id: 9541:IDH3G
uniprot id: A0A2K5WRH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9541:CAPN7
gene id: 9541:CAPN7
uniprot id: A0A2K5TW91
names: Similarity
messages: Belongs to the peptidase C2 family.

9541:RAD17
gene id: 9541:RAD17
uniprot id: A0A2K5UTI4
uniprot id: A0A2K5UTK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9541:MTURN
gene id: 9541:MTURN
uniprot id: A0A2K5WK10
uniprot id: A0A7N9C985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9541:ACER1
gene id: 9541:ACER1
uniprot id: A0A2K5VFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9541:TGIF2LX
gene id: 9541:TGIF2LX
uniprot id: Q8MID8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: May have a transcription role in testis.
messages: Nucleus

9541:SLC16A12
gene id: 9541:SLC16A12
uniprot id: A0A2K5WEE5
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102117847
gene id: 9541:LOC102117847
uniprot id: Q28476
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:C4BPA
gene id: 9541:C4BPA
uniprot id: A0A2K5UC71
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102128005
gene id: 9541:LOC102128005
uniprot id: A0A2K5V204
uniprot id: G7PIC9
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC101926276
gene id: 9541:LOC101926276
uniprot id: A0A2K5VBJ9
uniprot id: G7NTV6
uniprot id: G8F324
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SLC17A5
gene id: 9541:SLC17A5
uniprot id: A0A2K5VPS7
uniprot id: A0A2K5VPV6
uniprot id: G7P3G3
names: Subcellular Location Annotation
messages: Membrane

9541:OTUB1
gene id: 9541:OTUB1
uniprot id: A0A2K5U6Q4
uniprot id: A0A2K5U6T3
uniprot id: Q4R5L0
names: Similarity
messages: Belongs to the peptidase C65 family.

9541:SPARC
gene id: 9541:SPARC
uniprot id: A0A8J8XD95
uniprot id: G7P8R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9541:PRPS1
gene id: 9541:PRPS1
uniprot id: Q4R4U3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate.
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

9541:ACAT1
gene id: 9541:ACAT1
uniprot id: Q8HXY6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by potassium ions, but not sodium ions.
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrion
messages: Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).
messages: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.

9541:SLC35A3
gene id: 9541:SLC35A3
uniprot id: A0A7N9CEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9541:SMAD7
gene id: 9541:SMAD7
uniprot id: A0A2K5VD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9541:MPPE1
gene id: 9541:MPPE1
uniprot id: Q9GMS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity).
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
messages: cis-Golgi network membrane

9541:PPP2R3C
gene id: 9541:PPP2R3C
uniprot id: A0A8J8YFJ9
uniprot id: G7PA30
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:SLC39A7
gene id: 9541:SLC39A7
uniprot id: A0A8J8Y167
uniprot id: G7P2S2
names: Subcellular Location Annotation
messages: Membrane

9541:SKAP1
gene id: 9541:SKAP1
uniprot id: A0A2K5WPA7
uniprot id: G7PU68
names: Similarity
messages: Belongs to the SKAP family.

9541:EIF2AK1
gene id: 9541:EIF2AK1
uniprot id: Q4R8E0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues. Autophosphorylation at Thr-488 is required for kinase activation. The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: Cytoplasm
messages: In normal conditions, the protein kinase activity is inhibited; inhibition is relieved by various stress conditions (By similarity). Inhibited by heme: in presence of heme, forms a disulfide-linked inactive homodimer (By similarity). Heme depletion relieves inhibition and stimulates kinase activity by autophosphorylation. Inhibited by the heme metabolites biliverdin and bilirubin. Induced by oxidative stress generated by arsenite treatment. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity (By similarity). Protein kinase activity is also activated upon binding to the processed form of DELE1 (S-DELE1): interaction with S-DELE1 takes place in response to mitochondrial stress and triggers the integrated stress response (ISR) (By similarity).
messages: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).
messages: Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation (By similarity). Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer (By similarity). Interacts with DELE1; binds to the processed form of DELE1 (S-DELE1) in response to mitochondrial stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR) (By similarity).

9541:SLC18A2
gene id: 9541:SLC18A2
uniprot id: A0A2K5UVB8
names: Subcellular Location Annotation
messages: Membrane

9541:ALG6
gene id: 9541:ALG6
uniprot id: A0A2K5WWB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:GMFG
gene id: 9541:GMFG
uniprot id: A0A2K5W3N6
uniprot id: A0A2K5W3U4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9541:EWSR1
gene id: 9541:EWSR1
uniprot id: A0A2K5WSB9
uniprot id: A0A2K5WSC3
uniprot id: Q4R3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9541:MAPK8
gene id: 9541:MAPK8
uniprot id: A0A2K5WL44
uniprot id: A0A2K5WLC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9541:LPIN3
gene id: 9541:LPIN3
uniprot id: A0A2K5TPD9
names: Similarity
messages: Belongs to the lipin family.

9541:DECR2
gene id: 9541:DECR2
uniprot id: A0A2K5TJJ4
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9541:SMC4
gene id: 9541:SMC4
uniprot id: A0A2K5WAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9541:FOXP4
gene id: 9541:FOXP4
uniprot id: A0A2K5TJF8
names: Subcellular Location Annotation
messages: Nucleus

9541:CDKN3
gene id: 9541:CDKN3
uniprot id: A0A2K5WR43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9541:AIF1
gene id: 9541:AIF1
uniprot id: A0A8J8XFL1
uniprot id: G7P4P6
names: Subcellular Location Annotation
messages: ruffle membrane

9541:MYG1
gene id: 9541:MYG1
uniprot id: I7G3B2
names: Similarity
messages: Belongs to the MYG1 family.

9541:CDC42BPB
gene id: 9541:CDC42BPB
uniprot id: A0A2K5VKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9541:LOC102134628
gene id: 9541:LOC102134628
uniprot id: A0A2K5WS51
names: Similarity
messages: Belongs to the amidase family.

9541:TNS4
gene id: 9541:TNS4
uniprot id: A0A2K5TUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9541:KCTD15
gene id: 9541:KCTD15
uniprot id: A0A2K5VFG5
names: Subcellular Location Annotation
messages: Cell membrane

9541:CEP170
gene id: 9541:CEP170
uniprot id: A0A2K5U0N4
uniprot id: A0A2K5U0P2
names: Similarity
messages: Belongs to the CEP170 family.

9541:RHBG
gene id: 9541:RHBG
uniprot id: A0A2K5WZK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9541:POLR2C
gene id: 9541:POLR2C
uniprot id: A0A2K5UGS4
uniprot id: G7Q181
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9541:PLA2G1B
gene id: 9541:PLA2G1B
uniprot id: A0A7N9IEX0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:DSCC1
gene id: 9541:DSCC1
uniprot id: A0A2K5WAB7
names: Similarity
messages: Belongs to the DCC1 family.

9541:CXCL10
gene id: 9541:CXCL10
uniprot id: A0A2K5WKN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:LOC102137997
gene id: 9541:LOC102137997
uniprot id: A0A2K5UN85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:STRN3
gene id: 9541:STRN3
uniprot id: A0A2K5UPH5
uniprot id: A0A2K5UPH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9541:MSI2
gene id: 9541:MSI2
uniprot id: A0A2K5WC18
names: Similarity
messages: Belongs to the Musashi family.

9541:SFXN2
gene id: 9541:SFXN2
uniprot id: A0A2K5VRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9541:LOC102118223
gene id: 9541:LOC102118223
uniprot id: A0A7N9CZJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:DEFB113
gene id: 9541:DEFB113
uniprot id: A0A2K5U0I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:LPO
gene id: 9541:LPO
uniprot id: A0A2K5WIC2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Secreted

9541:GUCY2F
gene id: 9541:GUCY2F
uniprot id: A0A2K5VU62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9541:PLCB4
gene id: 9541:PLCB4
uniprot id: A0A2K5TNX4
uniprot id: A0A2K5TNX6
uniprot id: A0A2K5TNY0
uniprot id: A0A2K5TNZ1
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9541:PCOLCE
gene id: 9541:PCOLCE
uniprot id: A0A2K5WMV4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:TBXAS1
gene id: 9541:TBXAS1
uniprot id: A0A2K5UH73
uniprot id: Q2PG45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
messages: Endoplasmic reticulum membrane
messages: It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammalians.
messages: Monomer.

9541:DOP1A
gene id: 9541:DOP1A
uniprot id: A0A2K5V0M3
uniprot id: A0A2K5V0Q6
uniprot id: A0A2K5V0S2
names: Similarity
messages: Belongs to the dopey family.

9541:IL22
gene id: 9541:IL22
uniprot id: A0A8J8XHW8
uniprot id: G7PHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9541:LOC102123517
gene id: 9541:LOC102123517
uniprot id: A0A2K5W3F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CHRNA3
gene id: 9541:CHRNA3
uniprot id: A0A2K5TZM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:LOC102137168
gene id: 9541:LOC102137168
uniprot id: A0A2K5V5C7
names: Similarity
messages: Belongs to the PRAME family.

9541:DDX18
gene id: 9541:DDX18
uniprot id: A0A2K5VDJ7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9541:LOC102127229
gene id: 9541:LOC102127229
uniprot id: P67992
uniprot id: Q25CR9
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9541:TOP2B
gene id: 9541:TOP2B
uniprot id: A0A2K5VKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9541:CABYR
gene id: 9541:CABYR
uniprot id: Q4R3X7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with FSCB.
messages: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).
messages: Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).
messages: cytoskeleton
messages: flagellum

9541:PIAS3
gene id: 9541:PIAS3
uniprot id: A0A2K5TXI3
names: Similarity
messages: Belongs to the PIAS family.

9541:PMM1
gene id: 9541:PMM1
uniprot id: Q4R4J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9541:AOC2
gene id: 9541:AOC2
uniprot id: A0A8J8Y2F1
uniprot id: G7PUW5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9541:ACMSD
gene id: 9541:ACMSD
uniprot id: A0A2K5U9N6
uniprot id: A0A7N9CFZ9
uniprot id: A0A7N9IB17
uniprot id: A0A8J8YBQ4
uniprot id: G7PN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9541:GARIN6
gene id: 9541:GARIN6
uniprot id: Q4R323
names: Similarity
messages: Belongs to the GARIN family.

9541:DPYS
gene id: 9541:DPYS
uniprot id: A0A2K5W5E6
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9541:CPNE8
gene id: 9541:CPNE8
uniprot id: A0A8J8YL94
uniprot id: G7PHL3
uniprot id: Q4R7A5
names: Similarity
messages: Belongs to the copine family.

9541:DDRGK1
gene id: 9541:DDRGK1
uniprot id: G7PGU8
names: Similarity
messages: Belongs to the DDRGK1 family.

9541:NUTF2
gene id: 9541:NUTF2
uniprot id: I7G6Q2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9541:BLMH
gene id: 9541:BLMH
uniprot id: A0A2K5TUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9541:IFNGR1
gene id: 9541:IFNGR1
uniprot id: G7P327
uniprot id: I7GMW5
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9541:ZSCAN4
gene id: 9541:ZSCAN4
uniprot id: G7PZA1
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC48A1
gene id: 9541:SLC48A1
uniprot id: A0A2K5WP10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9541:CRYGS
gene id: 9541:CRYGS
uniprot id: A0A2K5TLY3
uniprot id: A0A8J8XT43
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:PBX3
gene id: 9541:PBX3
uniprot id: A0A2K5UKT8
uniprot id: A0A2K5UKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9541:PELI1
gene id: 9541:PELI1
uniprot id: A0A2K5VC28
uniprot id: G7PMB5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9541:CNOT7
gene id: 9541:CNOT7
uniprot id: A0A2K5WJS4
uniprot id: A0A2K5WJX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9541:DOCK7
gene id: 9541:DOCK7
uniprot id: A0A2K5V5M7
uniprot id: A0A2K5V5X2
uniprot id: A0A2K5V5Y4
uniprot id: A0A2K5V671
names: Similarity
messages: Belongs to the DOCK family.

9541:RALGPS2
gene id: 9541:RALGPS2
uniprot id: Q4R7W3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion.
messages: Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA.

9541:RSRP1
gene id: 9541:RSRP1
uniprot id: A0A2K5WBG8
uniprot id: Q4R626
names: Similarity
messages: Belongs to the RSRP family.

9541:DEFB121
gene id: 9541:DEFB121
uniprot id: A0A8J8Y8S5
uniprot id: G7PGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:C12H2orf76
gene id: 9541:C12H2orf76
uniprot id: A0A2K5TY70
uniprot id: G7PN51
names: Similarity
messages: Belongs to the UPF0538 family.

9541:IL1R1
gene id: 9541:IL1R1
uniprot id: A0A2K5WFG4
uniprot id: A0A7N9CMI5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:DLAT
gene id: 9541:DLAT
uniprot id: A0A2K5UNA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9541:SYN3
gene id: 9541:SYN3
uniprot id: A0A2K5V0P4
names: Similarity
messages: Belongs to the synapsin family.

9541:LOC102120369
gene id: 9541:LOC102120369
uniprot id: A0A2K5V493
uniprot id: G7PKT5
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9541:ARL5B
gene id: 9541:ARL5B
uniprot id: A0A7N9CLT2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:ORC3
gene id: 9541:ORC3
uniprot id: A0A2K5VX13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9541:DGKE
gene id: 9541:DGKE
uniprot id: A0A7N9CLX3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9541:TUBGCP2
gene id: 9541:TUBGCP2
uniprot id: A0A2K5W2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9541:PRKAA1
gene id: 9541:PRKAA1
uniprot id: A0A2K5TNP6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9541:SH3RF3
gene id: 9541:SH3RF3
uniprot id: A0A2K5X499
names: Similarity
messages: Belongs to the SH3RF family.

9541:MVD
gene id: 9541:MVD
uniprot id: A0A2K5X8J4
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9541:TINAG
gene id: 9541:TINAG
uniprot id: A0A2K5VFX9
names: Similarity
messages: Belongs to the peptidase C1 family.

9541:ATP5IF1
gene id: 9541:ATP5IF1
uniprot id: A0A8J8YQQ0
uniprot id: G7NWV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9541:TTC9C
gene id: 9541:TTC9C
uniprot id: Q9BGT1
names: Similarity
messages: Belongs to the TTC9 family.

9541:PHF19
gene id: 9541:PHF19
uniprot id: A0A2K5TMN9
uniprot id: G7PRJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9541:USP15
gene id: 9541:USP15
uniprot id: A0A2K5TK24
uniprot id: A0A2K5TK29
uniprot id: A0A8J8YA73
uniprot id: G7PIX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9541:ARL5A
gene id: 9541:ARL5A
uniprot id: A0A2K5W621
uniprot id: G7PKK8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:CD59
gene id: 9541:CD59
uniprot id: A0A2K5V4S1
uniprot id: G7PQF7
uniprot id: Q8SQ46
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane
messages: N- and O-glycosylated.
messages: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).

9541:OCM2
gene id: 9541:OCM2
uniprot id: A0A2K5W1N3
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9541:MOXD1
gene id: 9541:MOXD1
uniprot id: A0A2K5W5J9
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9541:TNFAIP1
gene id: 9541:TNFAIP1
uniprot id: A0A8J8YQH9
uniprot id: G7PTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9541:TAT
gene id: 9541:TAT
uniprot id: A0A8J8XI10
uniprot id: G7Q1K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9541:PRSS37
gene id: 9541:PRSS37
uniprot id: Q4R7Y7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position 67 which is replaced by Asn and Asn in position 69 which is replaced by Lys.
messages: Belongs to the peptidase S1 family.
messages: Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system.
messages: Secreted
messages: acrosome

9541:STING1
gene id: 9541:STING1
uniprot id: A0A2K5TV20
uniprot id: A0A2R3XZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9541:SYT1
gene id: 9541:SYT1
uniprot id: A0A2K5WAC0
uniprot id: G7PIJ5
uniprot id: Q60HC0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).
messages: Cytoplasm
messages: Glycosylated.
messages: Homotetramer (Probable). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
messages: The second C2 domain mediates interaction with SV2A and probably with STN2.
messages: chromaffin granule membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

9541:SNRPE
gene id: 9541:SNRPE
uniprot id: A0A2K5WYY9
uniprot id: G7NVE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9541:FGFR1OP2
gene id: 9541:FGFR1OP2
uniprot id: A0A2K5VDJ4
names: Similarity
messages: Belongs to the SIKE family.

9541:SMARCD2
gene id: 9541:SMARCD2
uniprot id: A0A2K5WM95
names: Similarity
messages: Belongs to the SMARCD family.

9541:SLC25A6
gene id: 9541:SLC25A6
uniprot id: I7GNQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9541:NR1I2
gene id: 9541:NR1I2
uniprot id: A0A2K5U3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:MAFA-B
gene id: 9541:MAFA-B
uniprot id: E5FNB1
names: Similarity
messages: Belongs to the MHC class I family.

9541:TNFSF10
gene id: 9541:TNFSF10
uniprot id: I7GIW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9541:RPL32
gene id: 9541:RPL32
uniprot id: G7P6U9
uniprot id: Q76KA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:UNC5C
gene id: 9541:UNC5C
uniprot id: A0A8J8YQ14
uniprot id: G7P5Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9541:DZIP1L
gene id: 9541:DZIP1L
uniprot id: A0A2K5VVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9541:CERS5
gene id: 9541:CERS5
uniprot id: A0A2K5VF92
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:PPP3R1
gene id: 9541:PPP3R1
uniprot id: A0A2K5UWF8
uniprot id: A0A7N9D4V0
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9541:BLK
gene id: 9541:BLK
uniprot id: A0A2K5WHE1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:IDNK
gene id: 9541:IDNK
uniprot id: A0A2K5UJQ4
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9541:ESYT2
gene id: 9541:ESYT2
uniprot id: A0A2K5V7X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:RHOXF1
gene id: 9541:RHOXF1
uniprot id: A0A2K5TM98
uniprot id: G7Q3L2
names: Subcellular Location Annotation
messages: Nucleus

9541:APOBEC3H
gene id: 9541:APOBEC3H
uniprot id: A0A2K5UY49
names: Subcellular Location Annotation
messages: Cytoplasm

9541:LAMP5
gene id: 9541:LAMP5
uniprot id: A0A8J8XGG8
uniprot id: G7PGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9541:IMP3
gene id: 9541:IMP3
uniprot id: A0A2K5UE45
uniprot id: G8F2V1
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9541:ANK2
gene id: 9541:ANK2
uniprot id: A0A2K5V2U5
uniprot id: A0A2K5V2U8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:NFKB2
gene id: 9541:NFKB2
uniprot id: A0A2K5UTZ1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:ERCC2
gene id: 9541:ERCC2
uniprot id: A0A2K5WL95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9541:LOC102144252
gene id: 9541:LOC102144252
uniprot id: A0A2K5W993
uniprot id: A0A2K5W9F1
uniprot id: G7PFF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LOC102121480
gene id: 9541:LOC102121480
uniprot id: A0A2K5VGZ9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:IMPA2
gene id: 9541:IMPA2
uniprot id: A0A2K5UR28
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9541:MKI67
gene id: 9541:MKI67
uniprot id: A0A2K5W4R7
uniprot id: A0A2K5W4U2
names: Subcellular Location Annotation
messages: Nucleus

9541:IL21
gene id: 9541:IL21
uniprot id: A0A2K5UL71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9541:EEF1A1
gene id: 9541:EEF1A1
uniprot id: Q4R5K0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9541:LOC102115550
gene id: 9541:LOC102115550
uniprot id: A0A2K5VA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9541:RNF43
gene id: 9541:RNF43
uniprot id: A0A2K5VQE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9541:PADI4
gene id: 9541:PADI4
uniprot id: A0A2K5USI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9541:SNX3
gene id: 9541:SNX3
uniprot id: A0A2K5X3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9541:PEX12
gene id: 9541:PEX12
uniprot id: I7G2Z0
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Required for protein import into peroxisomes.

9541:PPFIBP2
gene id: 9541:PPFIBP2
uniprot id: A0A2K5WYZ6
uniprot id: A0A2K5WZ00
uniprot id: A0A2K5WZ74
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9541:EIF3D
gene id: 9541:EIF3D
uniprot id: A0A2K5X7Q7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9541:EEF2K
gene id: 9541:EEF2K
uniprot id: A0A8J8XP58
uniprot id: G7Q0P5
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9541:LPAR2
gene id: 9541:LPAR2
uniprot id: A0A2K5TSP4
uniprot id: G7PX21
uniprot id: Q95KH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2 (By similarity).
messages: Membrane
messages: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity).

9541:SYT2
gene id: 9541:SYT2
uniprot id: A0A8J8YJ11
uniprot id: G7NWD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9541:KIF23
gene id: 9541:KIF23
uniprot id: A0A2K5VVJ5
uniprot id: A0A2K5VVL4
uniprot id: A0A2K5VVM4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:LOC102146887
gene id: 9541:LOC102146887
uniprot id: A0A2K5VSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9541:METTL14
gene id: 9541:METTL14
uniprot id: O02663
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.

9541:CLGN
gene id: 9541:CLGN
uniprot id: A0A8J8YPA9
uniprot id: G7P6B4
names: Similarity
messages: Belongs to the calreticulin family.

9541:ZFP30
gene id: 9541:ZFP30
uniprot id: Q9BE27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:BEX4
gene id: 9541:BEX4
uniprot id: A0A2K5UHM0
uniprot id: G7Q3B7
names: Similarity
messages: Belongs to the BEX family.

9541:PEX5
gene id: 9541:PEX5
uniprot id: A0A2K5U2J4
uniprot id: A0A2K5U2K6
uniprot id: G7PJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9541:SDR16C5
gene id: 9541:SDR16C5
uniprot id: A0A2K5TXG8
uniprot id: I7GNN2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:YIF1B
gene id: 9541:YIF1B
uniprot id: A0A2K5TQ98
uniprot id: A0A2K5TQA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9541:LOC102134652
gene id: 9541:LOC102134652
uniprot id: Q4R871
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9541:PARVA
gene id: 9541:PARVA
uniprot id: A0A2K5TN80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9541:RCAN3
gene id: 9541:RCAN3
uniprot id: A0A8J8YCU2
uniprot id: G7NVW0
names: Similarity
messages: Belongs to the RCAN family.

9541:TPBG
gene id: 9541:TPBG
uniprot id: Q4R8Y9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Highly glycosylated.
messages: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
messages: The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.

9541:GLRA3
gene id: 9541:GLRA3
uniprot id: A0A2K5WH11
uniprot id: A0A2K5WH44
uniprot id: A0A8J8Y2D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9541:NLGN1
gene id: 9541:NLGN1
uniprot id: A0A2K5W2U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9541:FOXM1
gene id: 9541:FOXM1
uniprot id: A0A2K5UQT6
uniprot id: A0A2K5UQV2
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM83C
gene id: 9541:FAM83C
uniprot id: A0A2K5WPX4
names: Similarity
messages: Belongs to the FAM83 family.

9541:NR1H4
gene id: 9541:NR1H4
uniprot id: A0A2K5TYF5
uniprot id: A0A2K5TYG5
uniprot id: G7PJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:HSD17B4
gene id: 9541:HSD17B4
uniprot id: A0A2K5X6D4
names: Subcellular Location Annotation
messages: Peroxisome

9541:DYNLL2
gene id: 9541:DYNLL2
uniprot id: A0A2K5VTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9541:LOC102133077
gene id: 9541:LOC102133077
uniprot id: G8F3F9
names: Similarity
messages: Belongs to the LCE family.

9541:LOC102123544
gene id: 9541:LOC102123544
uniprot id: Q95LN1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FOXB1
gene id: 9541:FOXB1
uniprot id: A0A2K5UFL3
names: Subcellular Location Annotation
messages: Nucleus

9541:SUN3
gene id: 9541:SUN3
uniprot id: Q95LV7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.
messages: The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.

9541:ZNF274
gene id: 9541:ZNF274
uniprot id: A0A2K5WHX2
uniprot id: Q4R8H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28.
messages: Nucleus
messages: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity).
messages: nucleolus

9541:NAA25
gene id: 9541:NAA25
uniprot id: A0A2K5WY54
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9541:MGST2
gene id: 9541:MGST2
uniprot id: A0A8J8XAJ7
uniprot id: G7P6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:GOT1
gene id: 9541:GOT1
uniprot id: A0A805Q1X1
uniprot id: Q25L56
uniprot id: Q4R5L1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9541:GADD45G
gene id: 9541:GADD45G
uniprot id: A0A2K5X2X3
names: Similarity
messages: Belongs to the GADD45 family.

9541:GRIK3
gene id: 9541:GRIK3
uniprot id: Q38PU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
messages: Cell membrane
messages: Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity).

9541:BAG6
gene id: 9541:BAG6
uniprot id: A0A2K5U6Y8
uniprot id: A0A2K5U6Y9
uniprot id: G7P4P8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9541:PRICKLE3
gene id: 9541:PRICKLE3
uniprot id: A0A2K5WIT2
uniprot id: A0A2K5WJ07
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9541:CA11
gene id: 9541:CA11
uniprot id: A0A8J8XZV3
uniprot id: G7PY41
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9541:FIS1
gene id: 9541:FIS1
uniprot id: A0A8J8XPZ8
uniprot id: G7P145
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9541:MARCHF4
gene id: 9541:MARCHF4
uniprot id: A0A8J8XS02
uniprot id: G7PLD9
names: Subcellular Location Annotation
messages: Membrane

9541:NUP88
gene id: 9541:NUP88
uniprot id: A0A2K5W4A1
names: Subcellular Location Annotation
messages: nuclear pore complex

9541:SLC30A6
gene id: 9541:SLC30A6
uniprot id: A0A2K5W6M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9541:PGLYRP1
gene id: 9541:PGLYRP1
uniprot id: Q18ND3
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9541:DOCK5
gene id: 9541:DOCK5
uniprot id: A0A2K5TVL2
names: Similarity
messages: Belongs to the DOCK family.

9541:ATG4A
gene id: 9541:ATG4A
uniprot id: A0A2K5X4I7
uniprot id: A0A2K5X4K0
uniprot id: A0A2K5X4K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9541:STXBP1
gene id: 9541:STXBP1
uniprot id: A0A2K5WGR0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:MTMR8
gene id: 9541:MTMR8
uniprot id: A0A2K5UYW1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9541:KCNB2
gene id: 9541:KCNB2
uniprot id: A0A2K5X219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

9541:CTSE
gene id: 9541:CTSE
uniprot id: A0A2K5UJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
messages: Secreted

9541:STAB1
gene id: 9541:STAB1
uniprot id: A0A2K5VS17
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:STAT4
gene id: 9541:STAT4
uniprot id: A0A2K5WUZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9541:BZW2
gene id: 9541:BZW2
uniprot id: A0A2K5X1J4
uniprot id: G7P0T4
names: Similarity
messages: Belongs to the BZW family.

9541:RNF112
gene id: 9541:RNF112
uniprot id: A0A2K5U3J2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:OVCA2
gene id: 9541:OVCA2
uniprot id: G8F5I1
names: Similarity
messages: Belongs to the LovG family.

9541:TIGD2
gene id: 9541:TIGD2
uniprot id: A0A2K5UIV0
uniprot id: G7P5X0
names: Subcellular Location Annotation
messages: Nucleus

9541:MS4A1
gene id: 9541:MS4A1
uniprot id: M4ZHZ6
names: Similarity
messages: Belongs to the MS4A family.

9541:USP50
gene id: 9541:USP50
uniprot id: Q4R6D3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
messages: The human ortholog is inactive.

9541:GPER1
gene id: 9541:GPER1
uniprot id: A0A2K5WYF2
uniprot id: A0A8J8YA21
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:EXO1
gene id: 9541:EXO1
uniprot id: A0A2K5UIR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9541:MAPRE1
gene id: 9541:MAPRE1
uniprot id: A0A2K5UDS3
uniprot id: I7GI83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9541:F3
gene id: 9541:F3
uniprot id: A0A2K5VX02
uniprot id: A0A2K5VX21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9541:NTF3
gene id: 9541:NTF3
uniprot id: A0A2K5UMJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9541:SLC35E3
gene id: 9541:SLC35E3
uniprot id: A0A2K5VC19
names: Subcellular Location Annotation
messages: Membrane

9541:NKIRAS2
gene id: 9541:NKIRAS2
uniprot id: A0A8J8XI33
uniprot id: G7PUT9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9541:CCL13
gene id: 9541:CCL13
uniprot id: A0A8J8YKY5
uniprot id: G7PU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:MECP2
gene id: 9541:MECP2
uniprot id: Q95LG8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Interacts with FNBP3. Interacts with CDKL5. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.

9541:FAM91A1
gene id: 9541:FAM91A1
uniprot id: A0A2K5X6H4
names: Similarity
messages: Belongs to the FAM91 family.

9541:SEC24A
gene id: 9541:SEC24A
uniprot id: A0A2K5W3V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:LPL
gene id: 9541:LPL
uniprot id: A0A2K5WW23
uniprot id: A0A7N9D851
uniprot id: I7GCW6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9541:OAT
gene id: 9541:OAT
uniprot id: A0A2K5WLK4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9541:MYO1D
gene id: 9541:MYO1D
uniprot id: A0A2K5V6Z7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:DPM1
gene id: 9541:DPM1
uniprot id: A0A2K5W3B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9541:MAML2
gene id: 9541:MAML2
uniprot id: A0A2K5UXJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9541:JMJD1C
gene id: 9541:JMJD1C
uniprot id: A0A2K5X741
names: Subcellular Location Annotation
messages: Nucleus

9541:TXNRD1
gene id: 9541:TXNRD1
uniprot id: A0A2K5VHF5
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9541:RTN4IP1
gene id: 9541:RTN4IP1
uniprot id: A0A2K5VTM8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9541:NAA10
gene id: 9541:NAA10
uniprot id: A0A2K5VKW9
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9541:APOA4
gene id: 9541:APOA4
uniprot id: A0A2K5VYS4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9541:AADACL3
gene id: 9541:AADACL3
uniprot id: A0A2K5TMV9
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9541:TLE5
gene id: 9541:TLE5
uniprot id: I7GPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:LOC102115526
gene id: 9541:LOC102115526
uniprot id: A0A2K5VU23
uniprot id: A0A2K5VU24
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9541:EPHB6
gene id: 9541:EPHB6
uniprot id: A0A2K5X5C5
names: Subcellular Location Annotation
messages: Membrane

9541:UGT2B20
gene id: 9541:UGT2B20
uniprot id: A0A2K5V064
uniprot id: O77649
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one.

9541:AMOTL1
gene id: 9541:AMOTL1
uniprot id: A0A2K5V4D4
uniprot id: A0A2K5V4D9
uniprot id: A0A7N9CZ16
uniprot id: A0A7N9DDM7
names: Similarity
messages: Belongs to the angiomotin family.

9541:SDHAF3
gene id: 9541:SDHAF3
uniprot id: A0A2K5UQN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9541:INPP5J
gene id: 9541:INPP5J
uniprot id: A0A2K5V4D2
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9541:ZSCAN32
gene id: 9541:ZSCAN32
uniprot id: A0A2K5TTN5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:ZDHHC7
gene id: 9541:ZDHHC7
uniprot id: A0A2K5W162
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CDC6
gene id: 9541:CDC6
uniprot id: A0A2K5VLB1
uniprot id: A0A2K5VLC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9541:GPN2
gene id: 9541:GPN2
uniprot id: G8F2G8
uniprot id: Q4R579
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9541:ADSL
gene id: 9541:ADSL
uniprot id: Q4R8X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9541:CCDC191
gene id: 9541:CCDC191
uniprot id: Q95KD7
names: Sequence Caution
messages: Contaminating sequence. Potential poly-A sequence.

9541:RRM1
gene id: 9541:RRM1
uniprot id: A0A8J8YCP7
uniprot id: G7PQZ6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9541:B3GNT8
gene id: 9541:B3GNT8
uniprot id: A0A2K5UK06
uniprot id: G7PXN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:DPAGT1
gene id: 9541:DPAGT1
uniprot id: A0A8J8Y1S0
uniprot id: G7PPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PPP1R2
gene id: 9541:PPP1R2
uniprot id: A0A8J8XWF8
uniprot id: G7NYS0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9541:LOC102120647
gene id: 9541:LOC102120647
uniprot id: A0A2K5X0X6
uniprot id: G7PRP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9541:FMC1
gene id: 9541:FMC1
uniprot id: A0A2K5WU95
uniprot id: G8F3T3
names: Similarity
messages: Belongs to the FMC1 family.

9541:SIAH1
gene id: 9541:SIAH1
uniprot id: A0A2K5VRW9
uniprot id: G7Q129
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9541:IL1RAPL1
gene id: 9541:IL1RAPL1
uniprot id: A0A2K5WTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9541:ARHGAP32
gene id: 9541:ARHGAP32
uniprot id: A0A2K5X3J4
uniprot id: A0A2K5X3S2
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9541:BMPR1A
gene id: 9541:BMPR1A
uniprot id: A0A2K5U1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:NDUFAF1
gene id: 9541:NDUFAF1
uniprot id: A0A2K5WVW9
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9541:MEIOB
gene id: 9541:MEIOB
uniprot id: Q4R8G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEIOB family.
messages: Chromosome
messages: Component of a multiprotein complex with RPA2 and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2.
messages: Cytoplasm
messages: Nucleus
messages: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.

9541:RRP15
gene id: 9541:RRP15
uniprot id: I7GPK6
names: Similarity
messages: Belongs to the RRP15 family.

9541:STXBP2
gene id: 9541:STXBP2
uniprot id: A0A2K5VM77
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:EPHX1
gene id: 9541:EPHX1
uniprot id: G8F5S8
uniprot id: Q2PG24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:MAN1C1
gene id: 9541:MAN1C1
uniprot id: A0A2K5WQ17
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:CNTNAP2
gene id: 9541:CNTNAP2
uniprot id: A0A2K5WT80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9541:TPRG1
gene id: 9541:TPRG1
uniprot id: A0A7N9CF06
names: Similarity
messages: Belongs to the TPRG1 family.

9541:CDCA8
gene id: 9541:CDCA8
uniprot id: A0A8J8XFX2
uniprot id: G7NUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9541:GRHL1
gene id: 9541:GRHL1
uniprot id: A0A2K5V1Q4
names: Subcellular Location Annotation
messages: Nucleus

9541:UTP3
gene id: 9541:UTP3
uniprot id: A0A2K5UFL0
names: Similarity
messages: Belongs to the SAS10 family.

9541:ARPC1B
gene id: 9541:ARPC1B
uniprot id: A0A2K5WSY0
uniprot id: G7P0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9541:VPS11
gene id: 9541:VPS11
uniprot id: A0A2K5X6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9541:AKT1
gene id: 9541:AKT1
uniprot id: G7PBQ9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9541:STAT6
gene id: 9541:STAT6
uniprot id: A0A2K5W338
uniprot id: G8F510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9541:INPP5A
gene id: 9541:INPP5A
uniprot id: A0A2K5WCA5
uniprot id: A0A2K5WCB1
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

9541:NKG7
gene id: 9541:NKG7
uniprot id: A0A2K5TM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:MIEF1
gene id: 9541:MIEF1
uniprot id: A0A2K5X623
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9541:CABS1
gene id: 9541:CABS1
uniprot id: Q95JW6
names: Function
names: Subcellular Location Annotation
messages: Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity).
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9541:CLDN1
gene id: 9541:CLDN1
uniprot id: A0A2K5WWF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:HARS2
gene id: 9541:HARS2
uniprot id: A0A2K5W7T9
uniprot id: A0A2K5W7W5
uniprot id: A0A7N9C9L7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9541:PKMYT1
gene id: 9541:PKMYT1
uniprot id: A0A2K5X347
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CYP11B1
gene id: 9541:CYP11B1
uniprot id: A0A2K5ULU3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:S100A1
gene id: 9541:S100A1
uniprot id: I7GDD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9541:GOLT1B
gene id: 9541:GOLT1B
uniprot id: A0A2K5VSP7
uniprot id: G7PK08
uniprot id: I7G9I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9541:KDM5C
gene id: 9541:KDM5C
uniprot id: A0A2K5X0F4
uniprot id: A0A2K5X139
uniprot id: G7Q2S8
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9541:ENY2
gene id: 9541:ENY2
uniprot id: A0A2K5VMX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9541:SPTSSA
gene id: 9541:SPTSSA
uniprot id: I7GMV0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102136862
gene id: 9541:LOC102136862
uniprot id: S6E293
names: Similarity
messages: Belongs to the MHC class II family.

9541:STX2
gene id: 9541:STX2
uniprot id: A0A2K5VP25
names: Similarity
messages: Belongs to the syntaxin family.

9541:LOC102142948
gene id: 9541:LOC102142948
uniprot id: G7NZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:AQP4
gene id: 9541:AQP4
uniprot id: A0A2K5WUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:LOC102145920
gene id: 9541:LOC102145920
uniprot id: A0A2K5W4P7
names: Similarity
messages: Belongs to the GAGE family.

9541:HSD17B5
gene id: 9541:HSD17B5
uniprot id: Q2XQY3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:UBE2I
gene id: 9541:UBE2I
uniprot id: A0A2K5VMB3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:ARF5
gene id: 9541:ARF5
uniprot id: I7G7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9541:NOP56
gene id: 9541:NOP56
uniprot id: Q95K50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP5/NOP56 family.
messages: Cytoplasm
messages: Involved in the early to middle stages of 60S ribosomal subunit biogenesis.
messages: Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Interacts with NOP1 and NOP58 (By similarity).
messages: nucleolus

9541:BCKDHA
gene id: 9541:BCKDHA
uniprot id: Q8HXY4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Bound potassium ions stabilize the protein structure.
messages: Heterotetramer of alpha and beta chains.
messages: Mitochondrion matrix
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9541:TARS2
gene id: 9541:TARS2
uniprot id: A0A2K5UQC0
uniprot id: A0A2K5UQD1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9541:SF3A1
gene id: 9541:SF3A1
uniprot id: A0A2K5UZ38
uniprot id: G7PF65
names: Subcellular Location Annotation
messages: Nucleus

9541:HSPA5
gene id: 9541:HSPA5
uniprot id: A0A2K5WXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

9541:MOB3B
gene id: 9541:MOB3B
uniprot id: A0A8J8YK25
uniprot id: G7PS66
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:TAF2
gene id: 9541:TAF2
uniprot id: A0A2K5WCB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9541:SDHAF1
gene id: 9541:SDHAF1
uniprot id: A0A2K5UG52
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9541:FAM167A
gene id: 9541:FAM167A
uniprot id: A0A2K5TLR1
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9541:LOC102142564
gene id: 9541:LOC102142564
uniprot id: A0A2K5UNB1
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9541:CHGA
gene id: 9541:CHGA
uniprot id: Q4R4V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9541:LOC102118346
gene id: 9541:LOC102118346
uniprot id: A0A2K5VDC3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:ANP32E
gene id: 9541:ANP32E
uniprot id: I7GLD0
names: Similarity
messages: Belongs to the ANP32 family.

9541:DMRT2
gene id: 9541:DMRT2
uniprot id: A0A2K5U3K0
names: Similarity
messages: Belongs to the DMRT family.

9541:RPL5
gene id: 9541:RPL5
uniprot id: A0A2K5TJC0
uniprot id: Q4R5M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11. Interacts with NVL in an ATP-dependent manner. Interacts with RRP1B (By similarity). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPL5 nuclear import for the assembly of ribosomal subunits (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B.
messages: Cytoplasm
messages: nucleolus

9541:AK3
gene id: 9541:AK3
uniprot id: I7GH42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9541:TRAF1
gene id: 9541:TRAF1
uniprot id: A0A2K5UUH5
uniprot id: G7PRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9541:XRCC3
gene id: 9541:XRCC3
uniprot id: A0A2K5VTM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9541:CYP24A1
gene id: 9541:CYP24A1
uniprot id: A0A2K5WTI6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:ATP2B4
gene id: 9541:ATP2B4
uniprot id: A0A2K5UGT1
uniprot id: A0A2K5UGU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:TEX10
gene id: 9541:TEX10
uniprot id: A0A8J8YD58
uniprot id: G7PRU3
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9541:CPSF7
gene id: 9541:CPSF7
uniprot id: A0A2K5TT78
names: Subcellular Location Annotation
messages: Nucleus

9541:IFI30
gene id: 9541:IFI30
uniprot id: A0A2K5WH71
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9541:DIS3
gene id: 9541:DIS3
uniprot id: A0A2K5UKV5
uniprot id: A0A2K5UKW9
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9541:IL11RA
gene id: 9541:IL11RA
uniprot id: A0A2K5VLM5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9541:TMEM256
gene id: 9541:TMEM256
uniprot id: A0A8J8YPW7
uniprot id: G7PTH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9541:HMGB2
gene id: 9541:HMGB2
uniprot id: A0A2K5U0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9541:FMOD
gene id: 9541:FMOD
uniprot id: A0A8J8XQM4
uniprot id: G7NVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9541:LOC102124806
gene id: 9541:LOC102124806
uniprot id: A0A2K5V886
uniprot id: G7PGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9541:TBL1XR1
gene id: 9541:TBL1XR1
uniprot id: A0A2K5UDM4
uniprot id: G7NZ35
names: Similarity
messages: Belongs to the WD repeat EBI family.

9541:WNT2
gene id: 9541:WNT2
uniprot id: A0A8J8XZG3
uniprot id: G7P2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:IL13RA2
gene id: 9541:IL13RA2
uniprot id: A0A2K5WCT5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9541:LOC102144897
gene id: 9541:LOC102144897
uniprot id: Q9GLZ9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
messages: Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
messages: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
messages: Nucleus

9541:ADH6
gene id: 9541:ADH6
uniprot id: A0A2K5W7A0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9541:MESD
gene id: 9541:MESD
uniprot id: I7GK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9541:ATP1A2
gene id: 9541:ATP1A2
uniprot id: A0A2K5UV79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MICAL3
gene id: 9541:MICAL3
uniprot id: A0A2K5WXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9541:LOC102130773
gene id: 9541:LOC102130773
uniprot id: A0A8J8YM65
uniprot id: G7PZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:LOC102120931
gene id: 9541:LOC102120931
uniprot id: A0A8J8Y0H3
uniprot id: G7PCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:RNF114
gene id: 9541:RNF114
uniprot id: Q4R3J4
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9541:TMCC1
gene id: 9541:TMCC1
uniprot id: A0A8J8XTR9
uniprot id: G7PIM5
names: Similarity
messages: Belongs to the TEX28 family.

9541:TCP1
gene id: 9541:TCP1
uniprot id: Q4R5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: centrosome
messages: cytosol

9541:IFIH1
gene id: 9541:IFIH1
uniprot id: A0A2K5WCB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9541:FLT1
gene id: 9541:FLT1
uniprot id: A0A2K5VAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:TMOD1
gene id: 9541:TMOD1
uniprot id: A0A2K5V4S9
uniprot id: G7PRW3
names: Subcellular Location Annotation
messages: cytoskeleton

9541:FRK
gene id: 9541:FRK
uniprot id: A0A2K5X900
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:HOXD3
gene id: 9541:HOXD3
uniprot id: A0A2K5TKT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:KRT32
gene id: 9541:KRT32
uniprot id: A0A2K5VW92
names: Similarity
messages: Belongs to the intermediate filament family.

9541:CLRN3
gene id: 9541:CLRN3
uniprot id: A0A8J8YJZ2
uniprot id: G7PEC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9541:CLCA1
gene id: 9541:CLCA1
uniprot id: A0A2K5TSF6
names: Similarity
messages: Belongs to the CLCR family.

9541:SRF
gene id: 9541:SRF
uniprot id: A0A2K5VDS4
names: Subcellular Location Annotation
messages: Nucleus

9541:HAO2
gene id: 9541:HAO2
uniprot id: A0A2K5W646
uniprot id: A0A2K5W668
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9541:MCPH1
gene id: 9541:MCPH1
uniprot id: Q5IFK1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNF chromatin remodeling complex (By similarity).
messages: BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, and mediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine and phosphotyrosine in the C-terminal tail of histone H2AX (By similarity).
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions (By similarity).
messages: centrosome

9541:LOC102137233
gene id: 9541:LOC102137233
uniprot id: A0A2K5TVY5
names: Similarity
messages: Belongs to the histone H2B family.

9541:USP16
gene id: 9541:USP16
uniprot id: A0A2K5VNN7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9541:PPP2R2B
gene id: 9541:PPP2R2B
uniprot id: A0A158SIQ6
uniprot id: A0A2K5U1Q0
uniprot id: A0A2K5U1Q5
uniprot id: A0A2K5U1U5
uniprot id: G7P8L1
uniprot id: Q4R8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: Membrane
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: cytoskeleton

9541:GRB10
gene id: 9541:GRB10
uniprot id: A0A2K5U186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9541:NAGA
gene id: 9541:NAGA
uniprot id: A0A2K5U017
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9541:PTGER3
gene id: 9541:PTGER3
uniprot id: A0A2K5TLN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:MFSD10
gene id: 9541:MFSD10
uniprot id: A0A2K5WMB8
names: Subcellular Location Annotation
messages: Membrane

9541:NANOS2
gene id: 9541:NANOS2
uniprot id: A0A8J8XQ98
uniprot id: G7PXX8
names: Similarity
messages: Belongs to the nanos family.

9541:SUSD6
gene id: 9541:SUSD6
uniprot id: A0A8J8YKY7
uniprot id: G7PAR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:P2RY1
gene id: 9541:P2RY1
uniprot id: A0A8J8XTW9
uniprot id: G7NZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SNX19
gene id: 9541:SNX19
uniprot id: A0A2K5WCE8
names: Similarity
messages: Belongs to the sorting nexin family.

9541:TAF5
gene id: 9541:TAF5
uniprot id: A0A2K5UVW2
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9541:TAS2R7
gene id: 9541:TAS2R7
uniprot id: G7PJU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9541:GDE1
gene id: 9541:GDE1
uniprot id: A0A2K5UZ26
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:LIN7C
gene id: 9541:LIN7C
uniprot id: A0A2K5VUH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9541:BORA
gene id: 9541:BORA
uniprot id: A0A2K5VU98
names: Similarity
messages: Belongs to the BORA family.

9541:LSM8
gene id: 9541:LSM8
uniprot id: G7P0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9541:CATSPERG
gene id: 9541:CATSPERG
uniprot id: Q4R6B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
messages: Belongs to the CATSPERG family.
messages: Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, SCLO6C1, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an additional auxiliary complex member. The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively. TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex. C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane.
messages: In mouse, Slco6c1 is an additional auxiliary subunit of the CatSper complex. It is unclear if the related SLCO6A1 protein performs the same role in non-rodent species.
messages: flagellum membrane

9541:NPR2
gene id: 9541:NPR2
uniprot id: A0A2K5WQF7
uniprot id: A0A2K5WQM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9541:OTULINL
gene id: 9541:OTULINL
uniprot id: A0A2K5WIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9541:GLDN
gene id: 9541:GLDN
uniprot id: A0A2K5WW73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ST6GALNAC4
gene id: 9541:ST6GALNAC4
uniprot id: Q2PG21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:GASK1A
gene id: 9541:GASK1A
uniprot id: A0A2K5UW93
names: Similarity
messages: Belongs to the GASK family.

9541:GCG
gene id: 9541:GCG
uniprot id: A0A2K5WWG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9541:USP3
gene id: 9541:USP3
uniprot id: A0A2K5UGL8
uniprot id: A0A2K5UGQ7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:ABRACL
gene id: 9541:ABRACL
uniprot id: A0A2K5WRC0
uniprot id: G7P319
names: Similarity
messages: Belongs to the costars family.

9541:ORC2
gene id: 9541:ORC2
uniprot id: A0A8J8XQH4
uniprot id: Q4R797
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9541:ATP6V0D1
gene id: 9541:ATP6V0D1
uniprot id: A0A2K5X956
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:RPS13
gene id: 9541:RPS13
uniprot id: A0A2K5V043
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9541:MASP1
gene id: 9541:MASP1
uniprot id: A0A2K5W2F7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:DDI1
gene id: 9541:DDI1
uniprot id: Q95JI3
names: Function
names: Similarity
messages: Belongs to the DDI1 family.
messages: Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).

9541:NDUFAF7
gene id: 9541:NDUFAF7
uniprot id: A0A2K5UX74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9541:URM1
gene id: 9541:URM1
uniprot id: A0A2K5UBC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9541:SPSB3
gene id: 9541:SPSB3
uniprot id: A0A2K5UYN2
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9541:PPFIA1
gene id: 9541:PPFIA1
uniprot id: A0A2K5V6C9
uniprot id: A0A2K5V6D7
uniprot id: A0A2K5V6H0
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9541:IL23A
gene id: 9541:IL23A
uniprot id: G7PIH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9541:STRIP2
gene id: 9541:STRIP2
uniprot id: A0A2K5WW75
names: Similarity
messages: Belongs to the STRIP family.

9541:PATL1
gene id: 9541:PATL1
uniprot id: A0A2K5WQ26
uniprot id: A0A2K5WQH7
names: Similarity
messages: Belongs to the PAT1 family.

9541:HIF3A
gene id: 9541:HIF3A
uniprot id: A0A2K5UJT7
uniprot id: A0A2K5UJU9
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:NUDT12
gene id: 9541:NUDT12
uniprot id: Q4R7L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Homodimer (By similarity). Homodimerization is essential for its catalytic activity and protein stability (By similarity). Interacts (via ANK repeats) with BLMH (By similarity).
messages: Peroxisome
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress (By similarity). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity).

9541:POMK
gene id: 9541:POMK
uniprot id: Q95JJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to the Ser/Thr protein kinase family, has no protein kinase activity and acts as a mannose kinase instead.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
messages: Endoplasmic reticulum membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity).

9541:SLC34A2
gene id: 9541:SLC34A2
uniprot id: A0A2K5UHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9541:ACHE
gene id: 9541:ACHE
uniprot id: A0A2K5WJG1
uniprot id: A0A2K5WJM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9541:ACER3
gene id: 9541:ACER3
uniprot id: A0A2K5WV75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9541:TLE3
gene id: 9541:TLE3
uniprot id: A0A2K5WCV9
uniprot id: A0A2K5WD15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:CYP1B1
gene id: 9541:CYP1B1
uniprot id: A0A2K5UT62
uniprot id: A0A7N9D2X8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:OPN4
gene id: 9541:OPN4
uniprot id: A0A2K5VU14
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NT5C2
gene id: 9541:NT5C2
uniprot id: A0A8J8YBL1
uniprot id: G7PDV7
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9541:IMMT
gene id: 9541:IMMT
uniprot id: A0A2K5VNW6
uniprot id: A0A2K5VP54
uniprot id: A0A2K5VPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9541:RPS6KA5
gene id: 9541:RPS6KA5
uniprot id: A0A2K5VW22
uniprot id: A0A2K5VW70
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:ACTR3B
gene id: 9541:ACTR3B
uniprot id: A0A2K5WHL6
names: Similarity
messages: Belongs to the actin family.

9541:DDIT4L
gene id: 9541:DDIT4L
uniprot id: A0A8J8XRQ5
uniprot id: G7P5Z9
names: Similarity
messages: Belongs to the DDIT4 family.

9541:SERPINA6
gene id: 9541:SERPINA6
uniprot id: A0A2K5WXZ3
names: Similarity
messages: Belongs to the serpin family.

9541:TAL2
gene id: 9541:TAL2
uniprot id: G7PRR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9541:OXSR1
gene id: 9541:OXSR1
uniprot id: A0A2K5U411
uniprot id: G7NYK6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9541:KDR
gene id: 9541:KDR
uniprot id: A0A2K5VE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:ADCYAP1R1
gene id: 9541:ADCYAP1R1
uniprot id: A0A2K5U6R8
names: Subcellular Location Annotation
messages: Membrane

9541:GLS2
gene id: 9541:GLS2
uniprot id: A0A2K5VU75
names: Similarity
messages: Belongs to the glutaminase family.

9541:LTV1
gene id: 9541:LTV1
uniprot id: A0A2K5WV65
names: Similarity
messages: Belongs to the LTV1 family.

9541:AVPR1B
gene id: 9541:AVPR1B
uniprot id: F6N687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9541:MAP1LC3C
gene id: 9541:MAP1LC3C
uniprot id: A0A2K5X4B0
names: Similarity
messages: Belongs to the ATG8 family.

9541:TUBB4B
gene id: 9541:TUBB4B
uniprot id: I7GH35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:MS4A5
gene id: 9541:MS4A5
uniprot id: A0A8J8Y424
uniprot id: G7PQ01
uniprot id: Q4R3P9
names: Similarity
messages: Belongs to the MS4A family.

9541:FKBP11
gene id: 9541:FKBP11
uniprot id: A0A2K5U4D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9541:RPL39L
gene id: 9541:RPL39L
uniprot id: A0A2K5UF67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:ADAMTS3
gene id: 9541:ADAMTS3
uniprot id: A0A2K5VFV4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:SPTLC3
gene id: 9541:SPTLC3
uniprot id: A0A2K5VQA1
uniprot id: G7PGZ7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9541:HPRT1
gene id: 9541:HPRT1
uniprot id: Q6LDD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
messages: Cytoplasm
messages: Homotetramer.

9541:TBX15
gene id: 9541:TBX15
uniprot id: A0A2K5VLD0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:BCL9L
gene id: 9541:BCL9L
uniprot id: A0A2K5WQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9541:SEH1L
gene id: 9541:SEH1L
uniprot id: A0A2K5UCH9
uniprot id: A0A7N9D3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9541:CD79A
gene id: 9541:CD79A
uniprot id: A0A2K5U9J5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:ABCB6
gene id: 9541:ABCB6
uniprot id: A0A2K5VM96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

9541:HLCS
gene id: 9541:HLCS
uniprot id: A0A2K5UVI9
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9541:TGFB1
gene id: 9541:TGFB1
uniprot id: A0A2K5TJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9541:OAS3
gene id: 9541:OAS3
uniprot id: A0A2K5X516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9541:FAM98A
gene id: 9541:FAM98A
uniprot id: A0A2K5UTV3
names: Similarity
messages: Belongs to the FAM98 family.

9541:KLHL3
gene id: 9541:KLHL3
uniprot id: A0A2K5WGW0
uniprot id: A0A2K5WH52
uniprot id: A0A7N9D103
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9541:RBFOX1
gene id: 9541:RBFOX1
uniprot id: A0A2K5WGN0
uniprot id: A0A2K5WGS3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9541:ADAMTS18
gene id: 9541:ADAMTS18
uniprot id: A0A2K5WBT7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:FAM214A
gene id: 9541:FAM214A
uniprot id: A0A2K5TQB7
uniprot id: A0A2K5TQC4
names: Similarity
messages: Belongs to the FAM214 family.

9541:SLC35F2
gene id: 9541:SLC35F2
uniprot id: A0A2K5VVI2
uniprot id: A0A7N9CJ66
uniprot id: G7PNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9541:NAB2
gene id: 9541:NAB2
uniprot id: A0A2K5X146
uniprot id: A0A2K5X172
uniprot id: A0A7N9CY18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9541:SNX10
gene id: 9541:SNX10
uniprot id: A0A2K5X9H7
uniprot id: G7P0P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9541:BTF3
gene id: 9541:BTF3
uniprot id: A0A2K5X8X8
names: Similarity
messages: Belongs to the NAC-beta family.

9541:ABLIM3
gene id: 9541:ABLIM3
uniprot id: A0A2K5VQ07
uniprot id: A0A2K5VQ10
uniprot id: A0A2K5VQ57
names: Subcellular Location Annotation
messages: Cytoplasm

9541:OXER1
gene id: 9541:OXER1
uniprot id: A0A2K5UQ10
uniprot id: G7PM35
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CCDC103
gene id: 9541:CCDC103
uniprot id: A0A2K5TU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9541:B9D2
gene id: 9541:B9D2
uniprot id: A0A8J8Y908
uniprot id: G7PXN5
names: Subcellular Location Annotation
messages: cilium basal body

9541:RHPN2
gene id: 9541:RHPN2
uniprot id: A0A2K5VF29
names: Similarity
messages: Belongs to the RHPN family.

9541:BPIFC
gene id: 9541:BPIFC
uniprot id: A0A2K5UK05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9541:ADIPOR1
gene id: 9541:ADIPOR1
uniprot id: A0A2K5UDE4
uniprot id: G8F668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:LOC102117390
gene id: 9541:LOC102117390
uniprot id: A0A2K5VRJ9
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9541:PTGES
gene id: 9541:PTGES
uniprot id: G7PRD3
uniprot id: Q6PWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Homotrimer.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: perinuclear region

9541:GRAP2
gene id: 9541:GRAP2
uniprot id: A0A7N9CZE0
uniprot id: A0A8J8XTA5
uniprot id: G7PFL4
uniprot id: Q4R3G7
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9541:PPP1R3B
gene id: 9541:PPP1R3B
uniprot id: A0A2K5TP98
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9541:LAGE3
gene id: 9541:LAGE3
uniprot id: A0A2K5WDF7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9541:KIF7
gene id: 9541:KIF7
uniprot id: A0A2K5VKT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:STUM
gene id: 9541:STUM
uniprot id: A0A2K5TT72
names: Subcellular Location Annotation
messages: Membrane

9541:LYPLAL1
gene id: 9541:LYPLAL1
uniprot id: A0A2K5W7H8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9541:FSCN1
gene id: 9541:FSCN1
uniprot id: A0A2K5U9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9541:PROS1
gene id: 9541:PROS1
uniprot id: A0A2K5VES4
uniprot id: G7NZ62
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102115394
gene id: 9541:LOC102115394
uniprot id: A0A7N9CNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MCOLN3
gene id: 9541:MCOLN3
uniprot id: A0A2K5V8F3
uniprot id: A0A7N9CPM3
uniprot id: A0A7N9CU40
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9541:SPR
gene id: 9541:SPR
uniprot id: A0A8J8YLX2
uniprot id: G7PMG9
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9541:CYP4F11
gene id: 9541:CYP4F11
uniprot id: A0A2K5X292
uniprot id: A8CBR8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:SPOUT1
gene id: 9541:SPOUT1
uniprot id: A0A2K5UGR3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9541:LOC102144154
gene id: 9541:LOC102144154
uniprot id: A0A2K5V9A2
uniprot id: G8F4K7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:NDUFA8
gene id: 9541:NDUFA8
uniprot id: A0A8J8XH60
uniprot id: G7PRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:SLC40A1
gene id: 9541:SLC40A1
uniprot id: A0A2K5V0L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9541:BSX
gene id: 9541:BSX
uniprot id: A0A2K5TZ41
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC101867207
gene id: 9541:LOC101867207
uniprot id: A0A2K5W2K7
uniprot id: Q4R7U5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9541:LOC107129805
gene id: 9541:LOC107129805
uniprot id: A0A7N9IBE1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9541:EMC6
gene id: 9541:EMC6
uniprot id: A0A2K5UKN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:GRID2
gene id: 9541:GRID2
uniprot id: A0A2K5VGR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:GAREM1
gene id: 9541:GAREM1
uniprot id: A0A2K5X4S9
names: Similarity
messages: Belongs to the GAREM family.

9541:PDK4
gene id: 9541:PDK4
uniprot id: A0A2K5UB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:PIGM
gene id: 9541:PIGM
uniprot id: Q4R4E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).

9541:EGR1
gene id: 9541:EGR1
uniprot id: A0A2K5UL28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9541:TTC26
gene id: 9541:TTC26
uniprot id: Q4R7Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFT56 family.
messages: Component of the IFT complex B. Interacts with IFT46; the interaction is direct.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
messages: cilium

9541:TSC22D1
gene id: 9541:TSC22D1
uniprot id: Q4R4H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Cytoplasm
messages: Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).
messages: Nucleus
messages: Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).

9541:SLC43A3
gene id: 9541:SLC43A3
uniprot id: A0A2K5V693
names: Subcellular Location Annotation
messages: Membrane

9541:PRKD2
gene id: 9541:PRKD2
uniprot id: A0A2K5WQU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Membrane

9541:SLC19A3
gene id: 9541:SLC19A3
uniprot id: A0A2K5W8N0
uniprot id: A0A7N9DDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

9541:CNIH2
gene id: 9541:CNIH2
uniprot id: A0A2K5W3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9541:COLGALT2
gene id: 9541:COLGALT2
uniprot id: A0A2K5UAQ2
uniprot id: A0A7N9CJM5
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9541:INPP4B
gene id: 9541:INPP4B
uniprot id: A0A2K5UC87
uniprot id: A0A2K5UC97
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9541:CERS2
gene id: 9541:CERS2
uniprot id: A0A2K5WN20
names: Subcellular Location Annotation
messages: Membrane

9541:UNKL
gene id: 9541:UNKL
uniprot id: A0A2K5X8X1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ITIH5
gene id: 9541:ITIH5
uniprot id: A0A2K5WMR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9541:EIF4E2
gene id: 9541:EIF4E2
uniprot id: A0A2K5U0W5
uniprot id: A0A2K5U0X6
uniprot id: A0A2K5U110
uniprot id: G7PKB1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9541:FEZ1
gene id: 9541:FEZ1
uniprot id: Q4R5K8
names: Similarity
messages: Belongs to the zygin family.

9541:YWHAB
gene id: 9541:YWHAB
uniprot id: A0A158SIP8
uniprot id: Q4R572
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).
messages: Inferred by similarity.
messages: Isoform Short contains a N-acetylmethionine at position 1.
messages: Melanosome
messages: The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

9541:SLC25A15
gene id: 9541:SLC25A15
uniprot id: G7PW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:ADAM23
gene id: 9541:ADAM23
uniprot id: A0A2K5UPI1
uniprot id: A0A2K5UPI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:VKORC1L1
gene id: 9541:VKORC1L1
uniprot id: A0A2K5WIN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:P2RX1
gene id: 9541:P2RX1
uniprot id: A0A2K5WNC1
uniprot id: G7PT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9541:ZSCAN2
gene id: 9541:ZSCAN2
uniprot id: A0A2K5U5D7
names: Subcellular Location Annotation
messages: Nucleus

9541:SERINC5
gene id: 9541:SERINC5
uniprot id: Q4R6L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

9541:LOC102146580
gene id: 9541:LOC102146580
uniprot id: A0A2K5UP26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PPDPF
gene id: 9541:PPDPF
uniprot id: A0A2K5X4I8
names: Similarity
messages: Belongs to the PPDPF family.

9541:LOC102123292
gene id: 9541:LOC102123292
uniprot id: A0A2K5UKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SGSM2
gene id: 9541:SGSM2
uniprot id: A0A2K5U5N8
uniprot id: A0A2K5U5R1
names: Similarity
messages: Belongs to the RUTBC family.

9541:TIGD3
gene id: 9541:TIGD3
uniprot id: A0A2K5UIP8
names: Subcellular Location Annotation
messages: Nucleus

9541:MYOF
gene id: 9541:MYOF
uniprot id: A0A2K5W417
uniprot id: A0A2K5W466
uniprot id: A0A2K5W479
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9541:UGT2B23
gene id: 9541:UGT2B23
uniprot id: Q9TSL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary.
messages: Microsome membrane
messages: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues.

9541:KIF1C
gene id: 9541:KIF1C
uniprot id: A0A2K5WN76
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:PSMA8
gene id: 9541:PSMA8
uniprot id: Q4R7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIF1A. Interacts with RAB7A. Interacts with PRKN. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

9541:EIF6
gene id: 9541:EIF6
uniprot id: A0A2K5UX53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9541:CYP2D6
gene id: 9541:CYP2D6
uniprot id: D9DB13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:SLIT2
gene id: 9541:SLIT2
uniprot id: A0A2K5TJ46
uniprot id: A0A2K5TJ59
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:FA2H
gene id: 9541:FA2H
uniprot id: Q4R4P4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity).
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: The N-terminal cytochrome b5 heme-binding domain is essential for catalytic activity.
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

9541:GADL1
gene id: 9541:GADL1
uniprot id: A0A8J8XCW0
uniprot id: G7NYB1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9541:TRAP1
gene id: 9541:TRAP1
uniprot id: A0A2K5WV36
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9541:LOC102133592
gene id: 9541:LOC102133592
uniprot id: A0A2K5U236
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9541:FEN1
gene id: 9541:FEN1
uniprot id: G7PPX3
uniprot id: Q4R5U5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300. Interacts with PCNA; can bind simultaneously to both PCNA and EP300. Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with WDR4; regulating its endonuclease activity.
messages: nucleolus
messages: nucleoplasm

9541:DDIT4
gene id: 9541:DDIT4
uniprot id: A0A2K5V7L1
uniprot id: G7PF25
names: Similarity
messages: Belongs to the DDIT4 family.

9541:CELF6
gene id: 9541:CELF6
uniprot id: A0A2K5U145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9541:PCMTD1
gene id: 9541:PCMTD1
uniprot id: A0A2K5UCL8
uniprot id: A0A2K5UCP9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9541:SLC25A32
gene id: 9541:SLC25A32
uniprot id: Q95J75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Transports folate across the inner membranes of mitochondria (By similarity). Can also transport FAD across the mitochondrial inner membrane (By similarity).

9541:AP1S1
gene id: 9541:AP1S1
uniprot id: A0A2K5UQD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9541:CYP2C9
gene id: 9541:CYP2C9
uniprot id: Q0HA18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:ELAPOR1
gene id: 9541:ELAPOR1
uniprot id: Q4R682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9541:POPDC3
gene id: 9541:POPDC3
uniprot id: A0A8J8Y1R0
uniprot id: G7P447
names: Similarity
messages: Belongs to the popeye family.

9541:MANSC1
gene id: 9541:MANSC1
uniprot id: Q95KG7
names: Subcellular Location Annotation
messages: Membrane

9541:GCN1
gene id: 9541:GCN1
uniprot id: A0A2K5WDP7
names: Similarity
messages: Belongs to the GCN1 family.

9541:CENPO
gene id: 9541:CENPO
uniprot id: A0A2K5UWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9541:MAN2A1
gene id: 9541:MAN2A1
uniprot id: A0A2K5VRI5
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9541:IP6K2
gene id: 9541:IP6K2
uniprot id: A0A2K5UWS7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:GJD4
gene id: 9541:GJD4
uniprot id: A0A2K5UY53
uniprot id: Q9N0B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Belongs to the connexin family. Delta-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:PAQR5
gene id: 9541:PAQR5
uniprot id: A0A8J8YRD9
uniprot id: G7P902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:LYAR
gene id: 9541:LYAR
uniprot id: A0A2K5V2R1
uniprot id: Q4R4E6
names: Subcellular Location Annotation
messages: Cytoplasm

9541:PRMT7
gene id: 9541:PRMT7
uniprot id: A0A2K5X8F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9541:ACSF2
gene id: 9541:ACSF2
uniprot id: A0A2K5VZB6
uniprot id: Q4R4Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Mitochondrion

9541:COPS7A
gene id: 9541:COPS7A
uniprot id: A0A8J8Y6V2
uniprot id: G7PJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9541:TMEM182
gene id: 9541:TMEM182
uniprot id: A0A2K5W3P0
uniprot id: A0A2K5W3P3
uniprot id: A0A7N9CPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9541:ERMN
gene id: 9541:ERMN
uniprot id: A0A8J8YRE1
uniprot id: G7PKL9
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9541:FGF10
gene id: 9541:FGF10
uniprot id: Q95K97
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:HSDL2
gene id: 9541:HSDL2
uniprot id: G7PRN7
names: Subcellular Location Annotation
messages: Peroxisome

9541:SLC17A3
gene id: 9541:SLC17A3
uniprot id: A0A8J8XYE1
uniprot id: G7P2K7
names: Subcellular Location Annotation
messages: Membrane

9541:ADGRF5
gene id: 9541:ADGRF5
uniprot id: A0A2K5W4I8
uniprot id: A0A2K5W4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9541:PSMA1
gene id: 9541:PSMA1
uniprot id: A0A2K5W387
uniprot id: Q4R3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with NOTCH3. Interacts with ZFAND1 (By similarity).

9541:PARN
gene id: 9541:PARN
uniprot id: A0A2K5VR35
uniprot id: A0A7N9DBD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9541:NID2
gene id: 9541:NID2
uniprot id: A0A2K5TKF7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9541:VIM
gene id: 9541:VIM
uniprot id: I7GH34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9541:NPPC
gene id: 9541:NPPC
uniprot id: A0A2K5WT12
uniprot id: G7PKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9541:LOC102138382
gene id: 9541:LOC102138382
uniprot id: A0A2K5UNQ2
uniprot id: G7P2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:HSP90B1
gene id: 9541:HSP90B1
uniprot id: Q4R520
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
messages: Phosphorylated.
messages: Sarcoplasmic reticulum lumen

9541:LOC102136550
gene id: 9541:LOC102136550
uniprot id: A0A2K5WF07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9541:ATP1B4
gene id: 9541:ATP1B4
uniprot id: A0A2K5WZW9
uniprot id: A0A8J8Y471
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:ROMO1
gene id: 9541:ROMO1
uniprot id: A0A2K5WQW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9541:LHB
gene id: 9541:LHB
uniprot id: Q6EV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9541:EMP1
gene id: 9541:EMP1
uniprot id: A0A2K5VF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:CPQ
gene id: 9541:CPQ
uniprot id: A0A2K5W7T5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome
messages: Secreted

9541:ALX4
gene id: 9541:ALX4
uniprot id: A0A2K5TXF7
names: Subcellular Location Annotation
messages: Nucleus

9541:IL2
gene id: 9541:IL2
uniprot id: Q29615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9541:PSD2
gene id: 9541:PSD2
uniprot id: A0A2K5V9X8
uniprot id: G7P8F8
names: Subcellular Location Annotation
messages: ruffle membrane

9541:MORF4L1
gene id: 9541:MORF4L1
uniprot id: A0A2K5UEY5
names: Subcellular Location Annotation
messages: Nucleus

9541:TMCC3
gene id: 9541:TMCC3
uniprot id: A0A2K5U6S9
uniprot id: A0A2K5U6U3
names: Similarity
messages: Belongs to the TEX28 family.

9541:SLC1A6
gene id: 9541:SLC1A6
uniprot id: A0A2K5W7Q9
uniprot id: G7PZN0
uniprot id: Q4R8D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CDK7
gene id: 9541:CDK7
uniprot id: A0A2K5TTM9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9541:MARCKSL1
gene id: 9541:MARCKSL1
uniprot id: A0A2K5UHI3
names: Similarity
messages: Belongs to the MARCKS family.

9541:SLC10A6
gene id: 9541:SLC10A6
uniprot id: A0A2K5W9F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9541:OCLN
gene id: 9541:OCLN
uniprot id: A0A8J8XBB2
uniprot id: G7P7N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9541:VAX2
gene id: 9541:VAX2
uniprot id: A0A2K5WMN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9541:XPO4
gene id: 9541:XPO4
uniprot id: A0A2K5UQV9
uniprot id: A0A2K5UQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9541:RYR3
gene id: 9541:RYR3
uniprot id: A0A2K5WD17
uniprot id: A0A2K5WD68
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9541:MEP1B
gene id: 9541:MEP1B
uniprot id: A0A2K5WR64
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC102122319
gene id: 9541:LOC102122319
uniprot id: A0A2K5UQ18
uniprot id: Q4W8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed (at protein level) in the kidney.
messages: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:15846473). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain. Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:15846473) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alph…

9541:C10H22orf39
gene id: 9541:C10H22orf39
uniprot id: A0A2K5X0N2
names: Similarity
messages: Belongs to the UPF0545 family.

9541:POLRMT
gene id: 9541:POLRMT
uniprot id: A0A2K5UVW4
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9541:TMEM97
gene id: 9541:TMEM97
uniprot id: Q4R8A8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. Sigma-2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol.

9541:SERINC2
gene id: 9541:SERINC2
uniprot id: A0A2K5VYY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:SLC9A2
gene id: 9541:SLC9A2
uniprot id: A0A2K5VT10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9541:ETFDH
gene id: 9541:ETFDH
uniprot id: A0A8J8Y4W4
uniprot id: G7P6H5
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9541:GORASP1
gene id: 9541:GORASP1
uniprot id: A0A2K5X944
names: Similarity
messages: Belongs to the GORASP family.

9541:RRAGC
gene id: 9541:RRAGC
uniprot id: A0A2K5V0N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9541:ELOVL2
gene id: 9541:ELOVL2
uniprot id: A0A2K5U2R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9541:GHSR
gene id: 9541:GHSR
uniprot id: A0A2K5WND3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9541:HABP2
gene id: 9541:HABP2
uniprot id: A0A2K5WHY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CBX3
gene id: 9541:CBX3
uniprot id: A0A2K5X776
names: Subcellular Location Annotation
messages: Nucleus

9541:PELI3
gene id: 9541:PELI3
uniprot id: A0A2K5TKX1
uniprot id: A0A2K5TKX7
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9541:THY1
gene id: 9541:THY1
uniprot id: A0A2K5U4H6
uniprot id: G7PPB4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9541:ACLY
gene id: 9541:ACLY
uniprot id: A0A2K5TWJ2
uniprot id: A0A2K5TWK6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9541:ZDHHC13
gene id: 9541:ZDHHC13
uniprot id: Q4R690
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with HTT. Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2.
messages: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CWC27
gene id: 9541:CWC27
uniprot id: Q4R713
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
messages: Belongs to the cyclophilin-type PPIase family.
messages: Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.
messages: Nucleus
messages: Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.

9541:SYNJ1
gene id: 9541:SYNJ1
uniprot id: A0A2K5UJ31
uniprot id: A0A2K5UJ57
uniprot id: A0A2K5UJ63
uniprot id: A0A2K5UJ78
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9541:TACSTD2
gene id: 9541:TACSTD2
uniprot id: A0A2K5UE71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:VDAC3
gene id: 9541:VDAC3
uniprot id: A0A2K5VWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9541:C1D
gene id: 9541:C1D
uniprot id: A0A8J8XV92
uniprot id: G7NZK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9541:MRTO4
gene id: 9541:MRTO4
uniprot id: A0A2K5V748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9541:DEGS1
gene id: 9541:DEGS1
uniprot id: A0A2K5TQ07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

9541:ARL8B
gene id: 9541:ARL8B
uniprot id: A0A2K5UBD4
uniprot id: A0A7N9CGD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9541:UGDH
gene id: 9541:UGDH
uniprot id: A0A2K5WLS0
uniprot id: G7P5F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9541:LOC102121606
gene id: 9541:LOC102121606
uniprot id: Q14T89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9541:SLC15A3
gene id: 9541:SLC15A3
uniprot id: A0A2K5UBU9
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9541:MDH2
gene id: 9541:MDH2
uniprot id: Q4R568
names: Activity Regulation
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is enhanced after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation.
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Enzyme activity is enhanced by acetylation.
messages: Homodimer.
messages: Mitochondrion matrix

9541:SLC12A4
gene id: 9541:SLC12A4
uniprot id: A0A2K5WTC3
uniprot id: A0A2K5WTN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:ZRANB2
gene id: 9541:ZRANB2
uniprot id: A0A2K5W9B9
uniprot id: A0A2K5W9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9541:ACADSB
gene id: 9541:ACADSB
uniprot id: Q4R4S2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:SAXO1
gene id: 9541:SAXO1
uniprot id: A0A2K5U5E5
uniprot id: Q4R7D3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with microtubules via the Mn regions.
messages: Belongs to the FAM154 family.
messages: May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature.
messages: The Mn regions are involved in microtubule-binding and stabilization at low temperature. They are required and sufficient for cilium targeting.
messages: The N-terminal region (residues 1-29) might play a role in centriole retention.
messages: centriole
messages: centrosome
messages: cilium axoneme
messages: cilium basal body
messages: flagellum axoneme

9541:SPTY2D1
gene id: 9541:SPTY2D1
uniprot id: A0A2K5VKW5
uniprot id: G7PQL1
names: Similarity
messages: Belongs to the SPT2 family.

9541:CSNK1A1L
gene id: 9541:CSNK1A1L
uniprot id: A0A2K5VAN7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SERPINC1
gene id: 9541:SERPINC1
uniprot id: A0A2K5UYN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9541:MFSD8
gene id: 9541:MFSD8
uniprot id: A0A2K5VAV3
uniprot id: A0A2K5VAW8
uniprot id: A0A2K5VB08
uniprot id: A0A2K5VB41
uniprot id: G8F4L8
names: Subcellular Location Annotation
messages: Membrane

9541:UTP6
gene id: 9541:UTP6
uniprot id: I7G6J7
names: Similarity
messages: Belongs to the UTP6 family.

9541:RNF7
gene id: 9541:RNF7
uniprot id: A0A7N9CCY2
names: Similarity
messages: Belongs to the RING-box family.

9541:ASB15
gene id: 9541:ASB15
uniprot id: A0A2K5TQ56
uniprot id: G7P0J8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:AFF1
gene id: 9541:AFF1
uniprot id: A0A2K5WIA6
uniprot id: A0A2K5WIA7
names: Similarity
messages: Belongs to the AF4 family.

9541:CCNT2
gene id: 9541:CCNT2
uniprot id: A0A2K5TJJ9
uniprot id: A0A8J8XC66
uniprot id: G7PN36
names: Similarity
messages: Belongs to the cyclin family.

9541:DRD5
gene id: 9541:DRD5
uniprot id: A0A2K5UER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CYP17A1
gene id: 9541:CYP17A1
uniprot id: G7PDV6
uniprot id: Q2XVA1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9541:FAM3D
gene id: 9541:FAM3D
uniprot id: A0A7N9CBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:TLE1
gene id: 9541:TLE1
uniprot id: A0A2K5VZS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:GALNT9
gene id: 9541:GALNT9
uniprot id: A0A2K5TUR1
uniprot id: Q9GM01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

9541:NAV2
gene id: 9541:NAV2
uniprot id: A0A2K5TYX2
uniprot id: A0A2K5TYZ0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9541:ERP29
gene id: 9541:ERP29
uniprot id: A0A2K5UDP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9541:API5
gene id: 9541:API5
uniprot id: A0A2K5WJH3
uniprot id: G7PQD5
names: Similarity
messages: Belongs to the API5 family.

9541:LSM5
gene id: 9541:LSM5
uniprot id: A0A7N9D8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9541:TXK
gene id: 9541:TXK
uniprot id: A0A2K5X607
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:ATG4C
gene id: 9541:ATG4C
uniprot id: A0A8J8YN27
uniprot id: G7NW13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9541:ETV1
gene id: 9541:ETV1
uniprot id: I7GHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:ZCCHC8
gene id: 9541:ZCCHC8
uniprot id: A0A2K5VS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9541:FOXA3
gene id: 9541:FOXA3
uniprot id: A0A2K5TR04
uniprot id: A0A7N9CHB5
names: Subcellular Location Annotation
messages: Nucleus

9541:MCM3
gene id: 9541:MCM3
uniprot id: A0A2K5TWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9541:CDK16
gene id: 9541:CDK16
uniprot id: A0A2K5TZN1
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9541:C14H11orf49
gene id: 9541:C14H11orf49
uniprot id: A0A2K5WLS8
uniprot id: A0A2K5WLV9
uniprot id: Q4R5A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSTPP1 family.
messages: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin.
messages: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
messages: centriolar satellite
messages: cytoskeleton

9541:GPNMB
gene id: 9541:GPNMB
uniprot id: A0A2K5TPL8
names: Similarity
messages: Belongs to the PMEL/NMB family.

9541:PARP10
gene id: 9541:PARP10
uniprot id: A0A2K5VQM7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:S100A2
gene id: 9541:S100A2
uniprot id: A0A2K5WB64
names: Similarity
messages: Belongs to the S-100 family.

9541:LOC102139994
gene id: 9541:LOC102139994
uniprot id: A0A2K5VY81
names: Similarity
messages: Belongs to the MHC class II family.

9541:TSEN15
gene id: 9541:TSEN15
uniprot id: A0A2K5U572
uniprot id: A0A2K5U5A3
names: Similarity
messages: Belongs to the SEN15 family.

9541:ING4
gene id: 9541:ING4
uniprot id: A0A2K5U7V5
uniprot id: G8F3S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:TSHZ2
gene id: 9541:TSHZ2
uniprot id: A0A8J8XNW7
uniprot id: G7PFZ9
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9541:RAD9A
gene id: 9541:RAD9A
uniprot id: A0A2K5WVB6
uniprot id: Q4R5X9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rad9 family.
messages: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity).
messages: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2. Interacts with DNAJC7 and RHNO1 (By similarity).
messages: Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex (By similarity).
messages: Nucleus

9541:STKLD1
gene id: 9541:STKLD1
uniprot id: Q4R793
names: Caution
names: Domain
names: Similarity
messages: Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
messages: The protein kinase domain is predicted to be catalytically inactive.

9541:NCL
gene id: 9541:NCL
uniprot id: Q4R4J7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with AICDA. Interacts with APTX. Interacts with C1QBP. Interacts with ERBB4. Interacts (via C-terminus) with FMR1 isoform 6 (via N-terminus). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1. Interacts with NSUN2. Interacts with NVL. Interacts (via N-terminus domain) with SETX. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT. Interacts with WDR46. Interacts with ZFP36. Interacts with LRRC34. Interacts with RRP1B. Interacts with HNRNPU; this interaction occurs during mitosis. Interacts with RIOK1; RIOK1 recruits NCL to PRMT5 for symmetrically methylation (By similarity). Interacts with ZBTB7B (By similarity). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (By similarity). Interacts with HDGF (By similarity). Interacts with ALKBH2.
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
messages: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
messages: Symmetrically methylated by PRMT5 (By similarity).
messages: nucleolus

9541:PPARD
gene id: 9541:PPARD
uniprot id: A0A2K5W3V1
uniprot id: G7P2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:GDF1
gene id: 9541:GDF1
uniprot id: A0A2K5V8P6
names: Subcellular Location Annotation
messages: Membrane

9541:RSPH3
gene id: 9541:RSPH3
uniprot id: A0A8J8XMF0
uniprot id: Q4R672
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

9541:ALG12
gene id: 9541:ALG12
uniprot id: A0A2K5X123
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:KCNN3
gene id: 9541:KCNN3
uniprot id: A0A2K5WZW7
uniprot id: A0A2K5X025
names: Subcellular Location Annotation
messages: Membrane

9541:KATNA1
gene id: 9541:KATNA1
uniprot id: G8F473
uniprot id: Q4R407
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit (By similarity). Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM (By similarity) Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42 (By similarity). Interacts with KATNB1 and KATNBL1 (By similarity). Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches (By similarity).
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9541:SPRY1
gene id: 9541:SPRY1
uniprot id: A0A2K5UCW3
uniprot id: G7P685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9541:HK1
gene id: 9541:HK1
uniprot id: A0A2K5TME5
uniprot id: A0A2K5TME6
names: Similarity
messages: Belongs to the hexokinase family.

9541:EMC2
gene id: 9541:EMC2
uniprot id: G7PCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9541:NDUFB7
gene id: 9541:NDUFB7
uniprot id: A0A2K5VGE4
uniprot id: G7PZM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:CCNF
gene id: 9541:CCNF
uniprot id: A0A2K5X3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: centriole
messages: perinuclear region

9541:HAT1
gene id: 9541:HAT1
uniprot id: A0A2K5VNQ2
uniprot id: A0A8J8YED4
uniprot id: G7PKT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9541:SLC25A5
gene id: 9541:SLC25A5
uniprot id: A0A2K5U4J6
uniprot id: A0A7N9CAS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9541:LOC102120735
gene id: 9541:LOC102120735
uniprot id: A0A2K5TMY4
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9541:CYP3A43
gene id: 9541:CYP3A43
uniprot id: B8K1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:GSX2
gene id: 9541:GSX2
uniprot id: A0A2K5WM55
names: Subcellular Location Annotation
messages: Nucleus

9541:GPR183
gene id: 9541:GPR183
uniprot id: A0A2K5UIV2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:PDIK1L
gene id: 9541:PDIK1L
uniprot id: A0A2K5VL47
uniprot id: A0A7N9CFE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CCT3
gene id: 9541:CCT3
uniprot id: A0A8J8YRI3
uniprot id: G7NV87
uniprot id: Q25QN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9541:GRM2
gene id: 9541:GRM2
uniprot id: A0A2K5WQG4
uniprot id: A0A8J8Y634
uniprot id: G7NZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9541:ERF
gene id: 9541:ERF
uniprot id: A0A2K5VB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:RP2
gene id: 9541:RP2
uniprot id: A0A2K5X3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9541:PROK1
gene id: 9541:PROK1
uniprot id: A0A2K5UMD6
uniprot id: G7NW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9541:MEGF11
gene id: 9541:MEGF11
uniprot id: A0A2K5TMM6
uniprot id: A0A2K5TMN2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:HSPA8
gene id: 9541:HSPA8
uniprot id: A0A2K5WNF9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:LOC101926364
gene id: 9541:LOC101926364
uniprot id: A0A2K5UA25
uniprot id: I7GNR1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:IFI27
gene id: 9541:IFI27
uniprot id: A0A2K5W5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9541:SPACA4
gene id: 9541:SPACA4
uniprot id: G7PY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9541:OPN1LW
gene id: 9541:OPN1LW
uniprot id: Q9XSX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9541:NCBP2L
gene id: 9541:NCBP2L
uniprot id: G7Q3F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9541:FKBP5
gene id: 9541:FKBP5
uniprot id: A0A8J8XA78
uniprot id: G7P3A6
names: Subcellular Location Annotation
messages: Nucleus

9541:MMP17
gene id: 9541:MMP17
uniprot id: A0A2K5UV35
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:CHRM5
gene id: 9541:CHRM5
uniprot id: A0A2K5UF81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9541:GLP1R
gene id: 9541:GLP1R
uniprot id: F8V479
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9541:ERRFI1
gene id: 9541:ERRFI1
uniprot id: A0A2K5VNH5
uniprot id: G7NTD0
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9541:ZSCAN21
gene id: 9541:ZSCAN21
uniprot id: A0A8J8XYU1
uniprot id: G7P0C2
names: Subcellular Location Annotation
messages: Nucleus

9541:IL19
gene id: 9541:IL19
uniprot id: A0A2K5W342
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9541:TNR
gene id: 9541:TNR
uniprot id: A0A2K5TRP8
uniprot id: A0A2K5TRR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9541:AQP3
gene id: 9541:AQP3
uniprot id: A0A2K5VFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9541:ACSL4
gene id: 9541:ACSL4
uniprot id: A0A8J8YEM6
uniprot id: G7Q3G4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:CCNJ
gene id: 9541:CCNJ
uniprot id: A0A2K5WK04
uniprot id: G7PDM7
names: Similarity
messages: Belongs to the cyclin family.

9541:TAS2R40
gene id: 9541:TAS2R40
uniprot id: A0A2K5UNT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:SPAST
gene id: 9541:SPAST
uniprot id: A0A2K5WXC4
uniprot id: A0A2K5WXC8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9541:WARS2
gene id: 9541:WARS2
uniprot id: A0A7N9IG81
uniprot id: G7NX63
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:ACTL6A
gene id: 9541:ACTL6A
uniprot id: A0A2K5UP87
names: Similarity
messages: Belongs to the actin family.

9541:VPS26B
gene id: 9541:VPS26B
uniprot id: A0A8J8XCF9
uniprot id: G7PPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9541:MALSU1
gene id: 9541:MALSU1
uniprot id: A0A2K5VHP6
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9541:COQ4
gene id: 9541:COQ4
uniprot id: A0A2K5WYR9
uniprot id: I7GI65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9541:DYNLT1
gene id: 9541:DYNLT1
uniprot id: A0A2K5V8A7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9541:RPSA
gene id: 9541:RPSA
uniprot id: I7G7S3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9541:NEK11
gene id: 9541:NEK11
uniprot id: Q8WNU8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc.
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Interacts with NEK2.
messages: Nucleus
messages: Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
messages: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
messages: nucleolus

9541:CASP2
gene id: 9541:CASP2
uniprot id: A0A2K5VYW8
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:TDRD7
gene id: 9541:TDRD7
uniprot id: A0A2K5W8A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9541:LOC101866379
gene id: 9541:LOC101866379
uniprot id: I7GK95
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9541:GUF1
gene id: 9541:GUF1
uniprot id: A0A2K5UMR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9541:IRF3
gene id: 9541:IRF3
uniprot id: A0A2K5V5R1
uniprot id: A0A2K5V5U4
uniprot id: G8F5X0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:RHBDL1
gene id: 9541:RHBDL1
uniprot id: A0A2K5V2Z1
names: Subcellular Location Annotation
messages: Membrane

9541:LOC101866254
gene id: 9541:LOC101866254
uniprot id: A0A2K5WRM2
uniprot id: G7NY87
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:ENTPD6
gene id: 9541:ENTPD6
uniprot id: A0A2K5TSX2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:GPR12
gene id: 9541:GPR12
uniprot id: A0A2K5TP16
uniprot id: G7PVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102126903
gene id: 9541:LOC102126903
uniprot id: A0A2K5WMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9541:LOC102138242
gene id: 9541:LOC102138242
uniprot id: A0A2K5UD58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RDH12
gene id: 9541:RDH12
uniprot id: A0A2K5U8Z4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:LOC102134053
gene id: 9541:LOC102134053
uniprot id: A0A2K5WWN3
names: Similarity
messages: Belongs to the histone H2B family.

9541:TYW3
gene id: 9541:TYW3
uniprot id: A0A2K5WAB5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9541:KCNV1
gene id: 9541:KCNV1
uniprot id: G7PCI9
uniprot id: Q9GKU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9541:ZDHHC9
gene id: 9541:ZDHHC9
uniprot id: A0A8J8XH94
uniprot id: G7Q3N4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:SLC29A3
gene id: 9541:SLC29A3
uniprot id: A0A2K5X6E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9541:PPP1R11
gene id: 9541:PPP1R11
uniprot id: G7P3V9
uniprot id: I7G3X7
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9541:VPS37B
gene id: 9541:VPS37B
uniprot id: A0A2K5WZU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:BAZ1B
gene id: 9541:BAZ1B
uniprot id: A0A2K5UR31
names: Subcellular Location Annotation
messages: Nucleus

9541:AP2A1
gene id: 9541:AP2A1
uniprot id: A0A2K5VZM7
uniprot id: A0A2K5VZV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9541:MPI
gene id: 9541:MPI
uniprot id: Q8HXX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9541:TPO
gene id: 9541:TPO
uniprot id: A0A2K5TRL1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:KCNH5
gene id: 9541:KCNH5
uniprot id: A0A8J8XZ53
uniprot id: G7PAH7
names: Subcellular Location Annotation
messages: Membrane

9541:CPN1
gene id: 9541:CPN1
uniprot id: A0A2K5UDJ6
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:LOC102137032
gene id: 9541:LOC102137032
uniprot id: A0A2K5UJ02
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9541:RPP14
gene id: 9541:RPP14
uniprot id: A0A2K5WD56
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9541:TNFSF11
gene id: 9541:TNFSF11
uniprot id: A0A2K5V2X5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9541:CACNB1
gene id: 9541:CACNB1
uniprot id: A0A2K5TYA2
uniprot id: A0A2K5TYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9541:PFKFB3
gene id: 9541:PFKFB3
uniprot id: A0A2K5V8T7
uniprot id: A0A2K5V8Y5
uniprot id: A0A2K5V903
uniprot id: A0A2K5V967
uniprot id: I7GP97
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9541:NAP1L4
gene id: 9541:NAP1L4
uniprot id: A0A2K5U0L3
uniprot id: A0A2K5U0P8
uniprot id: A0A2K5U0Q7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:CSNK1D
gene id: 9541:CSNK1D
uniprot id: A0A2K5WW40
uniprot id: A0A2K5WW54
uniprot id: I7G4F6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:RSPO3
gene id: 9541:RSPO3
uniprot id: A0A2K5UTQ7
names: Similarity
messages: Belongs to the R-spondin family.

9541:LYPD2
gene id: 9541:LYPD2
uniprot id: A0A2K5W0X5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:LOC102127013
gene id: 9541:LOC102127013
uniprot id: O97951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas.
messages: Microsome membrane
messages: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.

9541:HAS2
gene id: 9541:HAS2
uniprot id: A0A2K5V4S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9541:METTL15
gene id: 9541:METTL15
uniprot id: A0A2K5VIM8
uniprot id: Q4R7L2
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9541:SUSD1
gene id: 9541:SUSD1
uniprot id: A0A2K5VAB9
uniprot id: A0A2K5VAC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CYP2A26
gene id: 9541:CYP2A26
uniprot id: E0XJT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:MDGA2
gene id: 9541:MDGA2
uniprot id: A0A2K5V1X5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:EEF1B2
gene id: 9541:EEF1B2
uniprot id: I7GHJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9541:PABPC4
gene id: 9541:PABPC4
uniprot id: A0A2K5WWH5
uniprot id: A0A2K5WWI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9541:LOC102116763
gene id: 9541:LOC102116763
uniprot id: A0A8J8YGQ3
uniprot id: G7Q2M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9541:DCLK2
gene id: 9541:DCLK2
uniprot id: A0A2K5TVN1
uniprot id: A0A2K5TVQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:NPVF
gene id: 9541:NPVF
uniprot id: A0A2K5V6N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9541:MATN2
gene id: 9541:MATN2
uniprot id: A0A2K5W0B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:STARD3NL
gene id: 9541:STARD3NL
uniprot id: A0A2K5VI00
uniprot id: A0A2K5VI54
uniprot id: I7G8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:LGR5
gene id: 9541:LGR5
uniprot id: A0A2K5WIL2
uniprot id: G7PI19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:IFT46
gene id: 9541:IFT46
uniprot id: A0A2K5VPG7
uniprot id: A0A2K5VPL8
uniprot id: G8F447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9541:DLGAP3
gene id: 9541:DLGAP3
uniprot id: A0A2K5WLX0
names: Similarity
messages: Belongs to the SAPAP family.

9541:EARS2
gene id: 9541:EARS2
uniprot id: A0A2K5U2T6
uniprot id: Q4R4F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Mitochondrion matrix

9541:LIMK1
gene id: 9541:LIMK1
uniprot id: A0A2K5VXI2
uniprot id: A0A2K5VXR7
uniprot id: G8F3C7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9541:LOC102127670
gene id: 9541:LOC102127670
uniprot id: A0A2K5UN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LPCAT3
gene id: 9541:LPCAT3
uniprot id: A0A8J8Y2P3
uniprot id: G7PJP3
names: Subcellular Location Annotation
messages: Membrane

9541:DCT
gene id: 9541:DCT
uniprot id: A0A2K5VPR3
uniprot id: A0A8J8XD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9541:MOAP1
gene id: 9541:MOAP1
uniprot id: Q95KI4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNMA family.
messages: Extracellular vesicle membrane
messages: Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Interacts with BAX. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39 (By similarity). Interacts with RASSF6 (By similarity). Interacts with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. Does not interact with ATG8 proteins GABARAPL1, GABARAPL2 and GABARAP. Interacts with SQSTM1; promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1 (By similarity).
messages: Mitochondrion outer membrane
messages: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity).
messages: The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins MAP1LC3A, MAP1LC3B and MAP1LC3C.
messages: The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA)subdomain of gag.
messages: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.
messages: cytosol

9541:FAM83G
gene id: 9541:FAM83G
uniprot id: A0A2K5VLI2
names: Similarity
messages: Belongs to the FAM83 family.

9541:SYNE4
gene id: 9541:SYNE4
uniprot id: A0A2K5WQ94
names: Similarity
messages: Belongs to the nesprin family.

9541:LYVE1
gene id: 9541:LYVE1
uniprot id: A0A2K5UWG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PGPEP1
gene id: 9541:PGPEP1
uniprot id: A0A2K5UED9
uniprot id: A0A7N9CFL0
uniprot id: A0A8J8Y4Q6
uniprot id: G7PWZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9541:SPRY2
gene id: 9541:SPRY2
uniprot id: A0A2K5TMH2
uniprot id: A0A8J8XQS4
uniprot id: Q2PFN5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity).
messages: Belongs to the sprouty family.
messages: Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
messages: Forms heterodimers with SPRY1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (By similarity). Within the complex interacts with METTL13 (By similarity). Interacts with RAF1 (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation (By similarity). Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2 (By similarity). Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2 (By similarity). Interacts with GRB2 (By similarity). Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR (By similarity). Interacts (via C-terminus) with CAV1 (via C-terminus) (By similarity).
messages: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
messages: cytoskeleton
messages: ruffle membrane

9541:NPY
gene id: 9541:NPY
uniprot id: A0A2K5VHQ4
uniprot id: G7P0Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9541:CD53
gene id: 9541:CD53
uniprot id: A0A2K5W6N2
uniprot id: G7NW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:PPY
gene id: 9541:PPY
uniprot id: A0A2K5TNU2
uniprot id: G7PUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9541:SLC34A1
gene id: 9541:SLC34A1
uniprot id: A0A2K5UWI2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9541:AREG
gene id: 9541:AREG
uniprot id: A0A2K5U4V6
uniprot id: G7P5K2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FAM241A
gene id: 9541:FAM241A
uniprot id: A0A2K5X8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9541:LPXN
gene id: 9541:LPXN
uniprot id: A0A2K5U3C6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9541:RAD52
gene id: 9541:RAD52
uniprot id: A0A2K5U9U3
names: Similarity
messages: Belongs to the RAD52 family.

9541:LOC102136852
gene id: 9541:LOC102136852
uniprot id: G8F601
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9541:MRPL32
gene id: 9541:MRPL32
uniprot id: A0A2K5WUN2
uniprot id: I7GL70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9541:SENP5
gene id: 9541:SENP5
uniprot id: A0A2K5TX84
uniprot id: A0A2K5TX88
uniprot id: A0A2K5TX95
uniprot id: Q8WP32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C48 family.
messages: Interacts with CCAR2.
messages: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
messages: nucleolus

9541:GNG11
gene id: 9541:GNG11
uniprot id: G7P1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:PLK3
gene id: 9541:PLK3
uniprot id: A0A2K5X3U2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9541:LOC102144907
gene id: 9541:LOC102144907
uniprot id: A0A2K5UGW3
uniprot id: G7Q2G5
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9541:DPY19L3
gene id: 9541:DPY19L3
uniprot id: A0A2K5VH86
uniprot id: G7PX56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9541:KCTD16
gene id: 9541:KCTD16
uniprot id: A0A2K5UWN2
names: Subcellular Location Annotation
messages: Cell membrane

9541:SART3
gene id: 9541:SART3
uniprot id: A0A2K5WYB8
uniprot id: A0A2K5WYD1
uniprot id: G7PI53
names: Subcellular Location Annotation
messages: nucleoplasm

9541:SLC9A6
gene id: 9541:SLC9A6
uniprot id: A0A2K5WWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9541:RAPGEF2
gene id: 9541:RAPGEF2
uniprot id: A0A2K5VJ56
uniprot id: A0A2K5VJE9
uniprot id: A0A2K5VJJ4
uniprot id: A0A2K5VJK6
uniprot id: A0A7N9CTX2
uniprot id: A0A7N9CY37
uniprot id: G8F2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

9541:IL26
gene id: 9541:IL26
uniprot id: A0A2K5V5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9541:SEC61A2
gene id: 9541:SEC61A2
uniprot id: A0A2K5WEK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ADAMTS17
gene id: 9541:ADAMTS17
uniprot id: A0A2K5UCQ1
uniprot id: A0A2K5UCQ2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TMEM225
gene id: 9541:TMEM225
uniprot id: A0A8J8XYG3
uniprot id: G7PPD7
names: Subcellular Location Annotation
messages: Membrane

9541:APOLD1
gene id: 9541:APOLD1
uniprot id: A0A7N9CPN4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9541:SYBU
gene id: 9541:SYBU
uniprot id: A0A2K5WIU4
uniprot id: A0A2K5WIU6
uniprot id: A0A2K5WIV9
names: Subcellular Location Annotation
messages: Membrane

9541:PDE6A
gene id: 9541:PDE6A
uniprot id: A0A2K5X2J2
uniprot id: G7P8N7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:C5
gene id: 9541:C5
uniprot id: A0A2K5U1T1
names: Subcellular Location Annotation
messages: Secreted

9541:IDUA
gene id: 9541:IDUA
uniprot id: A0A2K5UZF4
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9541:LOC102125919
gene id: 9541:LOC102125919
uniprot id: A0A2K5W6B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9541:PSMD4
gene id: 9541:PSMD4
uniprot id: A0A2K5X8R1
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9541:NT5DC3
gene id: 9541:NT5DC3
uniprot id: A0A2K5X2E0
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9541:C3H7orf25
gene id: 9541:C3H7orf25
uniprot id: A0A2K5UKP3
uniprot id: A0A7N9D8R8
names: Similarity
messages: Belongs to the UPF0415 family.

9541:NIT2
gene id: 9541:NIT2
uniprot id: I7G4A5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9541:HEXA
gene id: 9541:HEXA
uniprot id: I7GH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9541:INTS7
gene id: 9541:INTS7
uniprot id: A0A2K5WG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9541:SPEM1
gene id: 9541:SPEM1
uniprot id: A0A2K5WTV9
uniprot id: G7PTH2
names: Subcellular Location Annotation
messages: Membrane

9541:GFRA3
gene id: 9541:GFRA3
uniprot id: A0A2K5VJ28
names: Similarity
messages: Belongs to the GDNFR family.

9541:KRT2
gene id: 9541:KRT2
uniprot id: G7PID3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:PRKCQ
gene id: 9541:PRKCQ
uniprot id: A0A2K5WLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9541:KLHL40
gene id: 9541:KLHL40
uniprot id: A0A2K5WTG3
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9541:MYH2
gene id: 9541:MYH2
uniprot id: A0A2K5VZW8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:LOC102142539
gene id: 9541:LOC102142539
uniprot id: A0A2K5UF00
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EFNB1
gene id: 9541:EFNB1
uniprot id: A0A7N9CAH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ELP3
gene id: 9541:ELP3
uniprot id: A0A2K5UAP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9541:PAX3
gene id: 9541:PAX3
uniprot id: A0A2K5V1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:SEMA4C
gene id: 9541:SEMA4C
uniprot id: A0A2K5VV83
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SLC12A8
gene id: 9541:SLC12A8
uniprot id: A0A2K5TK59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:RLN2
gene id: 9541:RLN2
uniprot id: G7PSF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9541:FAM234A
gene id: 9541:FAM234A
uniprot id: A0A2K5U7E8
uniprot id: A0A2K5U7H5
uniprot id: A0A2K5U7J1
names: Similarity
messages: Belongs to the FAM234 family.

9541:TFF2
gene id: 9541:TFF2
uniprot id: A0A7N9D9T8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SLC25A43
gene id: 9541:SLC25A43
uniprot id: A0A2K5VX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:BCKDK
gene id: 9541:BCKDK
uniprot id: A0A8J8YQ84
uniprot id: Q95LS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:TUBGCP4
gene id: 9541:TUBGCP4
uniprot id: A0A2K5TQ67
uniprot id: A0A2K5TQ93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9541:OTOF
gene id: 9541:OTOF
uniprot id: A0A2K5VJJ6
uniprot id: A0A2K5VJK4
names: Similarity
messages: Belongs to the ferlin family.

9541:PDP1
gene id: 9541:PDP1
uniprot id: A0A7N9CIZ6
uniprot id: A0A7N9D9J9
names: Similarity
messages: Belongs to the PP2C family.

9541:PRSS53
gene id: 9541:PRSS53
uniprot id: A0A2K5TZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:BOK
gene id: 9541:BOK
uniprot id: A0A2K5X835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9541:CFAP126
gene id: 9541:CFAP126
uniprot id: A0A2K5TRH1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9541:BMP4
gene id: 9541:BMP4
uniprot id: A0A2K5U6H8
uniprot id: A0A7N9I9M4
names: Similarity
messages: Belongs to the TGF-beta family.

9541:JPH2
gene id: 9541:JPH2
uniprot id: A0A2K5TZB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9541:KNG1
gene id: 9541:KNG1
uniprot id: A0A2K5WUB5
uniprot id: A0A2K5WUE1
names: Subcellular Location Annotation
messages: extracellular space

9541:IFT20
gene id: 9541:IFT20
uniprot id: G7PTW5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9541:KEG98 p05
gene id: 9541:KEG98_p05
uniprot id: C3W4Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9541:KLC1
gene id: 9541:KLC1
uniprot id: A0A2K5UQI2
uniprot id: A0A2K5UQK2
uniprot id: A0A2K5UQN5
uniprot id: A0A2K5UQN9
uniprot id: A0A2K5UQQ6
uniprot id: A0A2K5UR07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9541:HAUS3
gene id: 9541:HAUS3
uniprot id: A0A2K5U6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9541:RABGGTA
gene id: 9541:RABGGTA
uniprot id: A0A2K5UCG8
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9541:CAMK1D
gene id: 9541:CAMK1D
uniprot id: A0A2K5WZK2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:ATE1
gene id: 9541:ATE1
uniprot id: Q2PFX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the R-transferase family.
messages: Cytoplasm
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
messages: Monomer. Interacts with LIAT1 (By similarity).
messages: Nucleus

9541:TGFB2
gene id: 9541:TGFB2
uniprot id: A0A2K5TZI7
uniprot id: A0A7N9D1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9541:PCOLCE2
gene id: 9541:PCOLCE2
uniprot id: A0A8J8Y7D8
uniprot id: G7P007
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:RIF1
gene id: 9541:RIF1
uniprot id: A0A2K5V0S4
uniprot id: A0A2K5V0T1
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9541:HDHD3
gene id: 9541:HDHD3
uniprot id: A0A8J8YNL2
uniprot id: G7PRM3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9541:CD164L2
gene id: 9541:CD164L2
uniprot id: A0A2K5V420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9541:CAPN3
gene id: 9541:CAPN3
uniprot id: A0A2K5UIF5
uniprot id: A0A2K5UIG7
uniprot id: Q9GLG7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
messages: Cytoplasm
messages: Homodimer.
messages: Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.
messages: nucleolus

9541:C7H15orf40
gene id: 9541:C7H15orf40
uniprot id: A0A2K5X2R8
names: Similarity
messages: Belongs to the UPF0235 family.

9541:PPM1F
gene id: 9541:PPM1F
uniprot id: A0A2K5X977
uniprot id: A0A7N9D1S3
names: Similarity
messages: Belongs to the PP2C family.

9541:MRPL24
gene id: 9541:MRPL24
uniprot id: A0A2K5WEQ1
uniprot id: G8F6F0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9541:LOC102125912
gene id: 9541:LOC102125912
uniprot id: A0A2K5X6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:RFX2
gene id: 9541:RFX2
uniprot id: A0A2K5U4G0
uniprot id: A0A2K5U4L9
names: Subcellular Location Annotation
messages: Nucleus

9541:SLU7
gene id: 9541:SLU7
uniprot id: Q4R4P2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
messages: The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.

9541:HTR1F
gene id: 9541:HTR1F
uniprot id: A0A8J8YEW1
uniprot id: G7NZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9541:NIP7
gene id: 9541:NIP7
uniprot id: I7GDL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9541:POP4
gene id: 9541:POP4
uniprot id: A0A2K5UMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9541:CPA5
gene id: 9541:CPA5
uniprot id: A0A2K5VR26
uniprot id: Q4R7R2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Secreted

9541:THUMPD2
gene id: 9541:THUMPD2
uniprot id: A0A2K5UVW7
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9541:LOC101865400
gene id: 9541:LOC101865400
uniprot id: A5LFV9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FAM3C
gene id: 9541:FAM3C
uniprot id: A0A2K5VE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:PITX2
gene id: 9541:PITX2
uniprot id: A0A2K5X5I0
uniprot id: A0A2K5X5L8
uniprot id: A0A2K5X624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9541:EXOSC3
gene id: 9541:EXOSC3
uniprot id: A0A2K5TVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9541:DYNC1I1
gene id: 9541:DYNC1I1
uniprot id: A0A2K5TPG5
uniprot id: A0A2K5TSB8
uniprot id: A0A2K5TSF5
uniprot id: A0A8J8XIW1
uniprot id: G7P1B9
uniprot id: Q4R4Q2
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9541:ARPC2
gene id: 9541:ARPC2
uniprot id: A0A2K5UPC5
uniprot id: A0A2K5UPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9541:ZNF394
gene id: 9541:ZNF394
uniprot id: I7GK03
names: Subcellular Location Annotation
messages: Nucleus

9541:WHAMM
gene id: 9541:WHAMM
uniprot id: A0A2K5U9F0
names: Subcellular Location Annotation
messages: Membrane

9541:TMEM39A
gene id: 9541:TMEM39A
uniprot id: A0A2K5WRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9541:CCNYL1
gene id: 9541:CCNYL1
uniprot id: A0A2K5U770
uniprot id: A0A2K5U7B6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9541:CIAPIN1
gene id: 9541:CIAPIN1
uniprot id: A0A2K5X645
uniprot id: G7Q179
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9541:RPS23
gene id: 9541:RPS23
uniprot id: A0A2K5WRR8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9541:NEU1
gene id: 9541:NEU1
uniprot id: A0A2K5WS75
uniprot id: G8F3W3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9541:IQCG
gene id: 9541:IQCG
uniprot id: A0A2K5WFN2
uniprot id: A0A2K5WFU9
uniprot id: Q9GKR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC9 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.
messages: Component of the nexin-dynein regulatory complex (N-DRC). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca(2+). Interacts with the HSP70 proteins HSPA1L and HSPA8. May form a complex with CAMK4 and HSP70.
messages: Cytoplasm
messages: The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
messages: cilium
messages: cytoskeleton
messages: flagellum
messages: flagellum axoneme

9541:MBTPS2
gene id: 9541:MBTPS2
uniprot id: A0A7N9D5H2
uniprot id: A0A8J8XRU4
uniprot id: G7Q2C9
names: Similarity
messages: Belongs to the peptidase M50A family.

9541:DNAAF6
gene id: 9541:DNAAF6
uniprot id: A0A8J8XJR1
uniprot id: G7Q3E5
names: Similarity
messages: Belongs to the PIH1 family.

9541:MFF
gene id: 9541:MFF
uniprot id: A0A2K5X6A5
uniprot id: A0A2K5X6D5
uniprot id: A0A2K5X6D8
uniprot id: A0A2K5X6F5
uniprot id: A0A2K5X6U7
uniprot id: A0A7N9I9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9541:ENPP6
gene id: 9541:ENPP6
uniprot id: A0A2K5WNX3
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9541:IFI35
gene id: 9541:IFI35
uniprot id: A0A2K5WUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:CHAC2
gene id: 9541:CHAC2
uniprot id: A0A7N9D068
uniprot id: A0A8J8XXV5
uniprot id: G7PM72
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9541:SLC25A12
gene id: 9541:SLC25A12
uniprot id: A0A2K5W4N3
uniprot id: A0A2K5W4N6
uniprot id: A0A2K5W4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:GABARAPL1
gene id: 9541:GABARAPL1
uniprot id: A0A2K5X5D7
uniprot id: G7PJT4
names: Similarity
messages: Belongs to the ATG8 family.

9541:IDH3A
gene id: 9541:IDH3A
uniprot id: A0A2K5TMU6
uniprot id: A0A2K5TMV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9541:VKORC1
gene id: 9541:VKORC1
uniprot id: A0A2K5U002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CASP9
gene id: 9541:CASP9
uniprot id: A0A2K5VNT6
uniprot id: A0A2K5VNU7
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:NOS3
gene id: 9541:NOS3
uniprot id: A0A2K5TWM8
names: Similarity
messages: Belongs to the NOS family.

9541:LOC102139875
gene id: 9541:LOC102139875
uniprot id: P61251
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9541:LOC102136612
gene id: 9541:LOC102136612
uniprot id: A0A2K5UE17
names: Similarity
messages: Belongs to the histone H2B family.

9541:DCLRE1C
gene id: 9541:DCLRE1C
uniprot id: A0A2K5X8W2
uniprot id: E5FGH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9541:TMEM263
gene id: 9541:TMEM263
uniprot id: I7GII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9541:CTSW
gene id: 9541:CTSW
uniprot id: A0A2K5TYS6
names: Similarity
messages: Belongs to the peptidase C1 family.

9541:TRPV1
gene id: 9541:TRPV1
uniprot id: A0A2K5U3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendritic spine membrane

9541:PTN
gene id: 9541:PTN
uniprot id: A0A2K5VRE6
uniprot id: A0A2K5VRF2
uniprot id: A0A2K5VRP8
names: Similarity
messages: Belongs to the pleiotrophin family.

9541:SSMEM1
gene id: 9541:SSMEM1
uniprot id: Q4R309
names: Subcellular Location Annotation
messages: Membrane

9541:APOA2
gene id: 9541:APOA2
uniprot id: G7NXA8
uniprot id: P18656
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A2 family.
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Monomer. Interacts with NAXE and NDRG1 (By similarity).
messages: Plasma.
messages: Secreted

9541:PRDM4
gene id: 9541:PRDM4
uniprot id: A0A2K5VWI1
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9541:STK32B
gene id: 9541:STK32B
uniprot id: A0A2K5WRL0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TOPORS
gene id: 9541:TOPORS
uniprot id: A0A2K5X8H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:DYNLT5
gene id: 9541:DYNLT5
uniprot id: A0A2K5VPL7
uniprot id: G7NW29
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9541:GLT8D2
gene id: 9541:GLT8D2
uniprot id: Q4R3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Membrane

9541:DLL1
gene id: 9541:DLL1
uniprot id: A0A2K5X1M3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9541:GPR155
gene id: 9541:GPR155
uniprot id: A0A2K5TM64
names: Subcellular Location Annotation
messages: Membrane

9541:ROCK1
gene id: 9541:ROCK1
uniprot id: A0A2K5WB74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9541:PSMD1
gene id: 9541:PSMD1
uniprot id: A0A2K5U0W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9541:CYP2C8
gene id: 9541:CYP2C8
uniprot id: P33262
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By 3-methylcholanthrene (3MC).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:PPP6C
gene id: 9541:PPP6C
uniprot id: I7G633
names: Similarity
messages: Belongs to the PPP phosphatase family.

9541:FOXB2
gene id: 9541:FOXB2
uniprot id: A0A2K5UH33
names: Subcellular Location Annotation
messages: Nucleus

9541:CDC42BPA
gene id: 9541:CDC42BPA
uniprot id: A0A2K5U6C2
uniprot id: A0A2K5U6C8
uniprot id: A0A2K5U6E4
uniprot id: A0A2K5U6F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9541:CCDC25
gene id: 9541:CCDC25
uniprot id: A0A2K5VAU4
uniprot id: G7PCY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9541:NDST1
gene id: 9541:NDST1
uniprot id: A0A2K5UYC2
uniprot id: A0A2K5UYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:RPL34
gene id: 9541:RPL34
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:SUPT6H
gene id: 9541:SUPT6H
uniprot id: A0A8J8XF45
uniprot id: G7PTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9541:FAM172A
gene id: 9541:FAM172A
uniprot id: A0A2K5U8C0
uniprot id: A0A2K5U8D3
uniprot id: A0A2K5U8E0
uniprot id: A0A7N9CCK4
uniprot id: G7P7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

9541:ZC2HC1C
gene id: 9541:ZC2HC1C
uniprot id: A0A2K5UFQ8
uniprot id: Q9BGW4
names: Similarity
messages: Belongs to the ZC2HC1 family.

9541:TRAK2
gene id: 9541:TRAK2
uniprot id: A0A2K5WSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9541:AZGP1
gene id: 9541:AZGP1
uniprot id: A0A2K5TU41
names: Similarity
messages: Belongs to the MHC class I family.

9541:GALNT1
gene id: 9541:GALNT1
uniprot id: G7PWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:GTPBP3
gene id: 9541:GTPBP3
uniprot id: A0A2K5UBZ7
uniprot id: A0A2K5UC03
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9541:BTBD10
gene id: 9541:BTBD10
uniprot id: A0A2K5TQ72
uniprot id: A0A2K5TQ85
uniprot id: A0A2K5TQ90
uniprot id: G7PQP3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ALX1
gene id: 9541:ALX1
uniprot id: A0A8J8YN78
uniprot id: G7PIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:HLX
gene id: 9541:HLX
uniprot id: A0A2K5TZZ4
names: Subcellular Location Annotation
messages: Nucleus

9541:ATP6V0B
gene id: 9541:ATP6V0B
uniprot id: A0A2K5VUK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9541:OLFML1
gene id: 9541:OLFML1
uniprot id: A0A8J8XZH5
uniprot id: G7PQT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:VWA2
gene id: 9541:VWA2
uniprot id: A0A2K5UIE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:KCNA10
gene id: 9541:KCNA10
uniprot id: A0A2K5UGF0
uniprot id: G7NW43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:LOC102125569
gene id: 9541:LOC102125569
uniprot id: A0A2K5VWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9541:PLD2
gene id: 9541:PLD2
uniprot id: A0A2K5W8V3
names: Similarity
messages: Belongs to the phospholipase D family.

9541:SNX5
gene id: 9541:SNX5
uniprot id: A0A2K5WXX6
uniprot id: A0A7N9C732
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9541:TF
gene id: 9541:TF
uniprot id: A0A2K5UXZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9541:USP28
gene id: 9541:USP28
uniprot id: A0A2K5VZC2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:LOC101926677
gene id: 9541:LOC101926677
uniprot id: A0A2K5WEW9
uniprot id: A0A7N9DCN7
names: Subcellular Location Annotation
messages: Nucleus

9541:LIG4
gene id: 9541:LIG4
uniprot id: A0A2K5TPB9
uniprot id: A0A7N9CEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9541:PBX2
gene id: 9541:PBX2
uniprot id: A0A2K5VTH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9541:TBCCD1
gene id: 9541:TBCCD1
uniprot id: A0A2K5WF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9541:CA2
gene id: 9541:CA2
uniprot id: I7GPE6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:IRF5
gene id: 9541:IRF5
uniprot id: A0A2K5VH46
uniprot id: G7P0M4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:TPD52L2
gene id: 9541:TPD52L2
uniprot id: Q4R7B8
names: Similarity
messages: Belongs to the TPD52 family.

9541:VPS25
gene id: 9541:VPS25
uniprot id: A0A2K5V8X3
names: Similarity
messages: Belongs to the VPS25 family.

9541:LOC107126384
gene id: 9541:LOC107126384
uniprot id: A0A2K5UGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SPATA22
gene id: 9541:SPATA22
uniprot id: Q95JQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of a multiprotein complex with MEIOB and RPA2. Interacts with the complex BRME1:HSF2BP:BRCA2.
messages: Expressed in testis.
messages: Meiosis-specific protein required for homologous recombination in meiosis I.

9541:AP3S2
gene id: 9541:AP3S2
uniprot id: G7P9F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9541:SCD
gene id: 9541:SCD
uniprot id: A0A2K5TPH0
uniprot id: G7PDR3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9541:KCTD7
gene id: 9541:KCTD7
uniprot id: A0A2K5X953
names: Subcellular Location Annotation
messages: Cell membrane

9541:EXOSC4
gene id: 9541:EXOSC4
uniprot id: A0A2K5U584
names: Subcellular Location Annotation
messages: Cytoplasm

9541:PFN1
gene id: 9541:PFN1
uniprot id: A0A2K5VU17
uniprot id: I7GHA4
names: Similarity
messages: Belongs to the profilin family.

9541:B3GAT1
gene id: 9541:B3GAT1
uniprot id: A0A2K5U331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:MTF2
gene id: 9541:MTF2
uniprot id: A0A2K5WIX9
uniprot id: I7G9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9541:NR5A2
gene id: 9541:NR5A2
uniprot id: A0A2K5U6A3
uniprot id: A0A2K5U6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9541:FHIP2B
gene id: 9541:FHIP2B
uniprot id: A0A2K5VVP7
names: Similarity
messages: Belongs to the FHIP family.

9541:IL7R
gene id: 9541:IL7R
uniprot id: Q38IC7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9541:TSSK6
gene id: 9541:TSSK6
uniprot id: A0A2K5TPA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TFE3
gene id: 9541:TFE3
uniprot id: A0A8J8YBY1
uniprot id: G7Q2P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:DPF2
gene id: 9541:DPF2
uniprot id: A0A2K5X8E9
uniprot id: G7PPI4
names: Similarity
messages: Belongs to the requiem/DPF family.

9541:NOX3
gene id: 9541:NOX3
uniprot id: A0A2K5V091
names: Subcellular Location Annotation
messages: Membrane

9541:HMGB1
gene id: 9541:HMGB1
uniprot id: Q4R844
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B c…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9541:LOC102146135
gene id: 9541:LOC102146135
uniprot id: A0A2K5V452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9541:PALS1
gene id: 9541:PALS1
uniprot id: A0A2K5UDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

9541:SYNDIG1L
gene id: 9541:SYNDIG1L
uniprot id: A0A2K5WYG8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:POLM
gene id: 9541:POLM
uniprot id: A0A2K5VJH6
uniprot id: A0A2K5VJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9541:STAM
gene id: 9541:STAM
uniprot id: A0A2K5VRQ6
uniprot id: A0A7N9CM29
uniprot id: G7PEG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9541:LOC101926697
gene id: 9541:LOC101926697
uniprot id: G7PQY3
uniprot id: P68223
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9541:SGCG
gene id: 9541:SGCG
uniprot id: A0A2K5W3M6
uniprot id: G8F3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9541:PIGL
gene id: 9541:PIGL
uniprot id: A0A2K5UGL0
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9541:LOC102143578
gene id: 9541:LOC102143578
uniprot id: A0A2K5TKJ2
uniprot id: A0A8J8YDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9541:SCN3B
gene id: 9541:SCN3B
uniprot id: G7PPD3
uniprot id: Q8HXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
messages: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).

9541:SHC1
gene id: 9541:SHC1
uniprot id: A0A2K5VRP2
uniprot id: A0A2K5VRR9
uniprot id: A0A8J8Y8Q1
uniprot id: G7NUJ6
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ADAM22
gene id: 9541:ADAM22
uniprot id: A0A2K5U8N8
uniprot id: A0A2K5U8Q1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:TENT5C
gene id: 9541:TENT5C
uniprot id: A0A7N9D571
uniprot id: A0A8J8Y3K3
uniprot id: Q4R8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.
messages: Cytoplasm
messages: Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function. Interacts with PLK4; this interaction leads to the TENT5C recruitment into the centrosome.
messages: Nucleus
messages: centrosome

9541:SEMA7A
gene id: 9541:SEMA7A
uniprot id: A0A2K5TNJ4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PRPS2
gene id: 9541:PRPS2
uniprot id: A0A2K5UWH5
uniprot id: Q4R4R7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate.
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9541:CYP2D8
gene id: 9541:CYP2D8
uniprot id: D8KWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:RABAC1
gene id: 9541:RABAC1
uniprot id: A0A8J8Y7H0
uniprot id: G7PXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9541:ALPL
gene id: 9541:ALPL
uniprot id: A0A2K5U1L9
uniprot id: G7NUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9541:TM9SF3
gene id: 9541:TM9SF3
uniprot id: A0A2K5W768
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:ASB2
gene id: 9541:ASB2
uniprot id: A0A2K5VY87
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:UBE2H
gene id: 9541:UBE2H
uniprot id: A0A7N9D7E5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:FNBP1L
gene id: 9541:FNBP1L
uniprot id: A0A2K5UFN8
uniprot id: A0A2K5UFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9541:MAPK7
gene id: 9541:MAPK7
uniprot id: A0A2K5VW59
uniprot id: A0A2K5VW63
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9541:PLSCR1
gene id: 9541:PLSCR1
uniprot id: I7GJ06
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9541:SERPINF1
gene id: 9541:SERPINF1
uniprot id: I7GPF3
names: Similarity
messages: Belongs to the serpin family.

9541:CYP39A1
gene id: 9541:CYP39A1
uniprot id: Q2PFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9541:SEMA6A
gene id: 9541:SEMA6A
uniprot id: A0A2K5WVN5
uniprot id: A0A2K5WVQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102127544
gene id: 9541:LOC102127544
uniprot id: A0A2K5UGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TPST2
gene id: 9541:TPST2
uniprot id: G7PHG0
uniprot id: Q4R863
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane
messages: Homodimer. Can also form heterodimers with TPST1.
messages: N-glycosylated.
messages: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

9541:LOC102119500
gene id: 9541:LOC102119500
uniprot id: A0A2K5U2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PIF1
gene id: 9541:PIF1
uniprot id: A0A2K5VYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9541:SOX10
gene id: 9541:SOX10
uniprot id: A0A2K5USS4
names: Subcellular Location Annotation
messages: Nucleus

9541:LAPTM5
gene id: 9541:LAPTM5
uniprot id: I7G9Q1
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9541:XKR7
gene id: 9541:XKR7
uniprot id: A0A2K5TXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9541:LOC101925699
gene id: 9541:LOC101925699
uniprot id: A0A2K5TQS6
uniprot id: G7PH36
uniprot id: I7GE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SEMA3A
gene id: 9541:SEMA3A
uniprot id: A0A2K5VGJ0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MINAR2
gene id: 9541:MINAR2
uniprot id: A0A2K5WM24
names: Similarity
messages: Belongs to the MINAR family.

9541:RPS10
gene id: 9541:RPS10
uniprot id: I7G299
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9541:BCLAF3
gene id: 9541:BCLAF3
uniprot id: A0A2K5W8S2
uniprot id: A0A8J8XDS4
uniprot id: G7Q2C2
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9541:KIF27
gene id: 9541:KIF27
uniprot id: A0A2K5WVX3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:ELAVL4
gene id: 9541:ELAVL4
uniprot id: A0A2K5WYQ9
uniprot id: A0A2K5WYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9541:RPL29
gene id: 9541:RPL29
uniprot id: A0A2K5TPR9
uniprot id: A0A2K5UQ90
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9541:ACTR2
gene id: 9541:ACTR2
uniprot id: A0A2K5VKV4
uniprot id: A0A2K5VKX2
uniprot id: A0A2K5VL34
names: Similarity
messages: Belongs to the actin family.

9541:SNRNP200
gene id: 9541:SNRNP200
uniprot id: A0A2K5X457
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9541:TAP1
gene id: 9541:TAP1
uniprot id: A0A2K5WVJ0
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9541:TACC3
gene id: 9541:TACC3
uniprot id: A0A2K5VDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9541:IGF2
gene id: 9541:IGF2
uniprot id: A0A2K5VND9
uniprot id: A0A2K5VNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9541:ZC3HC1
gene id: 9541:ZC3HC1
uniprot id: A0A2K5UPS7
names: Subcellular Location Annotation
messages: Nucleus

9541:XPNPEP2
gene id: 9541:XPNPEP2
uniprot id: A0A8J8Y9Q8
uniprot id: G7Q3N2
names: Similarity
messages: Belongs to the peptidase M24B family.

9541:TMEM70
gene id: 9541:TMEM70
uniprot id: A0A7N9CGT8
names: Similarity
messages: Belongs to the TMEM70 family.

9541:QARS1
gene id: 9541:QARS1
uniprot id: Q4R5D7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:UNC13B
gene id: 9541:UNC13B
uniprot id: A0A2K5W9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

9541:PMEL
gene id: 9541:PMEL
uniprot id: Q4R7T2
names: Similarity
messages: Belongs to the PMEL/NMB family.

9541:CEP57
gene id: 9541:CEP57
uniprot id: A0A2K5WBP1
uniprot id: A0A2K5WBP5
uniprot id: G7PNI4
uniprot id: Q4R704
names: Similarity
messages: Belongs to the translokin family.

9541:PIGB
gene id: 9541:PIGB
uniprot id: A0A2K5WDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9541:IVD
gene id: 9541:IVD
uniprot id: G8F3Q0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:LOC102144039
gene id: 9541:LOC102144039
uniprot id: A0A8J8XSB1
uniprot id: A4L283
names: Similarity
messages: Belongs to the MHC class II family.

9541:FCGR3A
gene id: 9541:FCGR3A
uniprot id: Q8SPW2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (By similarity). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (By similarity). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (By similarity).
messages: Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG1 and IgG2.
messages: Lymphocytes and monocytes.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity). Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarit…
messages: Secreted
messages: Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.

9541:MAS1
gene id: 9541:MAS1
uniprot id: A0A2K5UBY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9541:KCNK18
gene id: 9541:KCNK18
uniprot id: A0A2K5U4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:LOC102119092
gene id: 9541:LOC102119092
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:RBP2
gene id: 9541:RBP2
uniprot id: A0A8J8XRQ6
uniprot id: G7P027
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:DKK3
gene id: 9541:DKK3
uniprot id: Q4R4I7
names: Similarity
messages: Belongs to the dickkopf family.

9541:XKR9
gene id: 9541:XKR9
uniprot id: A0A2K5WDW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9541:IPPK
gene id: 9541:IPPK
uniprot id: A0A2K5WBK7
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9541:MEP1A
gene id: 9541:MEP1A
uniprot id: A0A2K5TPQ3
uniprot id: G7P4S4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LTF
gene id: 9541:LTF
uniprot id: A0A2K5WLE6
names: Similarity
messages: Belongs to the transferrin family.

9541:SCN1B
gene id: 9541:SCN1B
uniprot id: A0A2K5V251
uniprot id: A0A2K5V2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9541:SLC22A1
gene id: 9541:SLC22A1
uniprot id: A0A2K5X5L2
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9541:EDA
gene id: 9541:EDA
uniprot id: A0A2K5VYD5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:LDB3
gene id: 9541:LDB3
uniprot id: A0A2K5ULE9
uniprot id: A0A2K5ULR2
names: Subcellular Location Annotation
messages: Z line

9541:ASB9
gene id: 9541:ASB9
uniprot id: A0A2K5V5D5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:THAP5
gene id: 9541:THAP5
uniprot id: Q4R7M0
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleaved by HTRA2 during apoptosis.
messages: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.
messages: Interacts with HTRA2; under apoptotic conditions. Interacts with ABRAXAS2.
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Nucleus

9541:CCL23
gene id: 9541:CCL23
uniprot id: A0A2K5WBA5
uniprot id: G7PU52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:SLC35A2
gene id: 9541:SLC35A2
uniprot id: A0A2K5WST2
uniprot id: A0A2K5WSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9541:HCK
gene id: 9541:HCK
uniprot id: Q95M30
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Interacts with ADAM15. Interacts with FASLG. Interacts with ARRB1 and ARRB2. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with CBL. Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with WDCP.
messages: Lysosome
messages: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).
messages: Nucleus
messages: Palmitoylation requires prior myristoylation. Palmitoylation is required for caveolar localization (By similarity).
messages: Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation at Tyr-389 increases kinase activity. Phosphorylation at Tyr-500 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-500, suggesting that this site may be a target of other kinases (By similarity).
messages: Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-389 is required for optimal activity. Phosphorylation at Tyr-500 inhibits kinase activity (By similarity).
messages: Ubiquitinated by CBL, leading to its degradation via the proteasome.
messages: caveola
messages: cytoskeleton
messages: cytosol
messages: focal adhesion
messages: secretory vesicle

9541:LOC101925320
gene id: 9541:LOC101925320
uniprot id: Q4R8D3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9541:TSPAN11
gene id: 9541:TSPAN11
uniprot id: A0A7N9D223
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:POLR2H
gene id: 9541:POLR2H
uniprot id: G7NYZ5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9541:SHBG
gene id: 9541:SHBG
uniprot id: A0A2K5X8C8
uniprot id: A0A2K5X8X0
uniprot id: G7PTI7
uniprot id: Q4R6W8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102132017
gene id: 9541:LOC102132017
uniprot id: A0A2K5UEN0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9541:LOC102137780
gene id: 9541:LOC102137780
uniprot id: A0A2K5VHL8
uniprot id: G7PNJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9541:CCL11
gene id: 9541:CCL11
uniprot id: A0A2K5U1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:IPO8
gene id: 9541:IPO8
uniprot id: A0A2K5UFC7
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CCDC124
gene id: 9541:CCDC124
uniprot id: A0A2K5TNQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9541:SEPTIN11
gene id: 9541:SEPTIN11
uniprot id: A0A2K5VXY1
uniprot id: A0A2K5VXY3
uniprot id: A0A2K5VY70
uniprot id: A0A7N9D789
uniprot id: Q4R555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity). Forms homooligomers (By similarity). GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN7, SEPTIN9 and SEPTIN12 (By similarity).
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: Synapse
messages: axon
messages: cytoskeleton
messages: dendritic spine

9541:SFRP2
gene id: 9541:SFRP2
uniprot id: A0A2K5WND6
uniprot id: G8F2Z7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CTNNBL1
gene id: 9541:CTNNBL1
uniprot id: A0A2K5X1L3
uniprot id: G7PGF2
names: Subcellular Location Annotation
messages: Nucleus

9541:PEX26
gene id: 9541:PEX26
uniprot id: Q9BE65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-26 family.
messages: Interacts (via its cytoplasmic domain) with PEX6; interaction is direct and is ATP-dependent. Interacts with PEX1; interaction is indirect and is mediated via interaction with PEX6.
messages: Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane.
messages: Peroxisome membrane

9541:IRAK1BP1
gene id: 9541:IRAK1BP1
uniprot id: A0A2K5V741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9541:GPC3
gene id: 9541:GPC3
uniprot id: A0A2K5VK50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9541:MYO5A
gene id: 9541:MYO5A
uniprot id: A0A2K5W139
uniprot id: A0A2K5W143
uniprot id: A0A2K5W1G4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:POSTN
gene id: 9541:POSTN
uniprot id: A0A2K5VW02
uniprot id: A0A2K5VW23
uniprot id: A0A2K5VW96
uniprot id: A0A2K5VWG9
uniprot id: G7PW19
names: Subcellular Location Annotation
messages: extracellular matrix

9541:ADCY6
gene id: 9541:ADCY6
uniprot id: A0A2K5TPL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9541:PAXBP1
gene id: 9541:PAXBP1
uniprot id: A0A2K5W6G2
uniprot id: A0A2K5W6I8
names: Similarity
messages: Belongs to the GCF family.

9541:RARA
gene id: 9541:RARA
uniprot id: A0A2K5V0N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:MAPK14
gene id: 9541:MAPK14
uniprot id: A0A2K5WJV8
uniprot id: A0A2K5WJW8
uniprot id: A0A8J8Y992
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9541:LDHC
gene id: 9541:LDHC
uniprot id: A0A2K5WD20
uniprot id: Q4R6K1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9541:NKAIN3
gene id: 9541:NKAIN3
uniprot id: I7GNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9541:VAT1L
gene id: 9541:VAT1L
uniprot id: A0A8J8YT23
uniprot id: G7Q1P8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9541:LOC102143300
gene id: 9541:LOC102143300
uniprot id: A0A2K5VH37
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9541:MTERF2
gene id: 9541:MTERF2
uniprot id: A0A2K5UMK4
names: Similarity
messages: Belongs to the mTERF family.

9541:IFNA8
gene id: 9541:IFNA8
uniprot id: G7PS89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9541:AKAP8
gene id: 9541:AKAP8
uniprot id: A0A2K5W0C4
names: Similarity
messages: Belongs to the AKAP95 family.

9541:LOC102129291
gene id: 9541:LOC102129291
uniprot id: A0A8J8Y8V5
uniprot id: A7XEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9541:TMTC3
gene id: 9541:TMTC3
uniprot id: A0A2K5WSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:TMEM234
gene id: 9541:TMEM234
uniprot id: A0A2K5VPQ7
uniprot id: A0A2K5VPR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9541:EGFL7
gene id: 9541:EGFL7
uniprot id: A0A2K5VD40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EGFL8
gene id: 9541:EGFL8
uniprot id: A0A2K5UHB9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:BLOC1S1
gene id: 9541:BLOC1S1
uniprot id: A0A2K5TX73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9541:CALB2
gene id: 9541:CALB2
uniprot id: A0A2K5VV88
uniprot id: G7Q1K6
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9541:ACKR2
gene id: 9541:ACKR2
uniprot id: A0A2K5UF52
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

9541:LOC102145339
gene id: 9541:LOC102145339
uniprot id: A0A2K5UPJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:THOC5
gene id: 9541:THOC5
uniprot id: A0A2K5U7V1
uniprot id: A0A2K5U7V6
uniprot id: G7PHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9541:XCR1
gene id: 9541:XCR1
uniprot id: A0A8J8XJL1
uniprot id: G7NY37
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:KCNJ11
gene id: 9541:KCNJ11
uniprot id: A0A8J8YNU2
uniprot id: G7PQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9541:HSPD1
gene id: 9541:HSPD1
uniprot id: I7G496
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9541:LOC102126820
gene id: 9541:LOC102126820
uniprot id: A0A2K5V7K6
uniprot id: G7PTU1
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9541:AGAP2
gene id: 9541:AGAP2
uniprot id: A0A2K5X7K4
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9541:PITPNM2
gene id: 9541:PITPNM2
uniprot id: A0A2K5WDU9
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9541:ARPC1A
gene id: 9541:ARPC1A
uniprot id: I7GK84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9541:PNMA2
gene id: 9541:PNMA2
uniprot id: G7PCY0
uniprot id: Q9GMU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9541:SNCA
gene id: 9541:SNCA
uniprot id: G7P5X2
uniprot id: P61142
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9541:ZNF75D
gene id: 9541:ZNF75D
uniprot id: A0A2K5X9F7
names: Subcellular Location Annotation
messages: Nucleus

9541:AQP1
gene id: 9541:AQP1
uniprot id: A0A2K5TYP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

9541:CFHR2
gene id: 9541:CFHR2
uniprot id: A0A2K5WEE7
uniprot id: G8F5N7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FTH1
gene id: 9541:FTH1
uniprot id: A0A2K5UDS4
uniprot id: I7GH92
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9541:DDX52
gene id: 9541:DDX52
uniprot id: A0A2K5X8Z0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9541:POP5
gene id: 9541:POP5
uniprot id: A0A2K5WQZ8
uniprot id: G7PJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9541:DYNC2LI1
gene id: 9541:DYNC2LI1
uniprot id: A0A2K5VIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9541:MMUT
gene id: 9541:MMUT
uniprot id: Q8HXX1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
messages: Cytoplasm
messages: Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.
messages: Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor.
messages: Mitochondrion
messages: Mitochondrion matrix

9541:GLYATL1
gene id: 9541:GLYATL1
uniprot id: A0A2K5WAQ4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9541:CBR3
gene id: 9541:CBR3
uniprot id: A0A2K5UW11
uniprot id: G7P114
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9541:IMPG1
gene id: 9541:IMPG1
uniprot id: A0A2K5V7R1
uniprot id: A0A2K5V7T1
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9541:DEFB123
gene id: 9541:DEFB123
uniprot id: A0A8J8XK90
uniprot id: G7PGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:IK
gene id: 9541:IK
uniprot id: I7G2E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9541:SNX11
gene id: 9541:SNX11
uniprot id: A0A8J8XAR5
uniprot id: G7PU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9541:SELENBP1
gene id: 9541:SELENBP1
uniprot id: A0A2K5V8R1
uniprot id: I7GK56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9541:ODC1
gene id: 9541:ODC1
uniprot id: A0A2K5WKX8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9541:CELF4
gene id: 9541:CELF4
uniprot id: A0A2K5VD81
uniprot id: A0A2K5VD83
uniprot id: Q4R535
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity).

9541:LOC102117971
gene id: 9541:LOC102117971
uniprot id: A0A2K5UG48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:ABCB11
gene id: 9541:ABCB11
uniprot id: A0A2K5U2H2
names: Subcellular Location Annotation
messages: Endosome

9541:HARS1
gene id: 9541:HARS1
uniprot id: A0A2K5U175
uniprot id: A0A2K5U1A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9541:ATG12
gene id: 9541:ATG12
uniprot id: I7GIF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9541:KCNE1
gene id: 9541:KCNE1
uniprot id: C7S322
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9541:SPC25
gene id: 9541:SPC25
uniprot id: A0A8J8YF95
uniprot id: G7PKR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9541:REV3L
gene id: 9541:REV3L
uniprot id: A0A2K5TLA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9541:SLCO3A1
gene id: 9541:SLCO3A1
uniprot id: A0A2K5WG09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PATJ
gene id: 9541:PATJ
uniprot id: A0A2K5V353
names: Subcellular Location Annotation
messages: tight junction

9541:CRYBB3
gene id: 9541:CRYBB3
uniprot id: A0A8J8YC17
uniprot id: G7PHE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9541:DGAT1
gene id: 9541:DGAT1
uniprot id: A0A2K5WCM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9541:CDK5RAP3
gene id: 9541:CDK5RAP3
uniprot id: A0A2K5WTQ7
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9541:COQ8B
gene id: 9541:COQ8B
uniprot id: A0A2K5WMA1
uniprot id: G7PXM3
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9541:RDH10
gene id: 9541:RDH10
uniprot id: A0A2K5UVZ5
uniprot id: A0A2K5UW13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:DHX29
gene id: 9541:DHX29
uniprot id: A0A2K5WBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9541:PLIN5
gene id: 9541:PLIN5
uniprot id: A0A2K5X6B3
names: Similarity
messages: Belongs to the perilipin family.

9541:PSMD5
gene id: 9541:PSMD5
uniprot id: Q5IFJ8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome (By similarity).
messages: Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.

9541:MZT2B
gene id: 9541:MZT2B
uniprot id: A0A2K5WDI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9541:NTSR2
gene id: 9541:NTSR2
uniprot id: Q2PFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ANAPC16
gene id: 9541:ANAPC16
uniprot id: A0A2K5X5W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9541:NAA40
gene id: 9541:NAA40
uniprot id: A0A2K5U6T7
uniprot id: A0A7N9CM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:RPS8
gene id: 9541:RPS8
uniprot id: G7P6T4
uniprot id: Q4R6P8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
messages: Membrane

9541:IRF7
gene id: 9541:IRF7
uniprot id: A0A2K5WXS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:AICDA
gene id: 9541:AICDA
uniprot id: A0A2K5WJH5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:MGMT
gene id: 9541:MGMT
uniprot id: G7PEI1
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9541:LOC102121175
gene id: 9541:LOC102121175
uniprot id: A0A2K5UV29
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

9541:NSDHL
gene id: 9541:NSDHL
uniprot id: A0A2K5UDV0
uniprot id: G7Q1Y4
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9541:RBFOX2
gene id: 9541:RBFOX2
uniprot id: A0A2K5UZD0
uniprot id: A0A2K5UZE0
uniprot id: A0A2K5UZG0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9541:CHRNA2
gene id: 9541:CHRNA2
uniprot id: A0A2K5WB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:KCNK6
gene id: 9541:KCNK6
uniprot id: A0A2K5V5D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:MED7
gene id: 9541:MED7
uniprot id: A0A8J8YMB4
uniprot id: G7P6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9541:FAM20C
gene id: 9541:FAM20C
uniprot id: A0A2K5VCN7
names: Similarity
messages: Belongs to the FAM20 family.

9541:SCRN3
gene id: 9541:SCRN3
uniprot id: A0A2K5WDH9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9541:MRPL58
gene id: 9541:MRPL58
uniprot id: A0A2K5UIS6
names: Subcellular Location Annotation
messages: Mitochondrion

9541:LOC102121500
gene id: 9541:LOC102121500
uniprot id: G7P2L9
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:IL5RA
gene id: 9541:IL5RA
uniprot id: C3VEW9
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9541:HOXC11
gene id: 9541:HOXC11
uniprot id: A0A2K5TLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:XRCC1
gene id: 9541:XRCC1
uniprot id: A0A2K5X0B0
names: Subcellular Location Annotation
messages: Nucleus

9541:TBCE
gene id: 9541:TBCE
uniprot id: A0A2K5WD55
uniprot id: A0A2K5WD80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Cytoplasm

9541:PRPF4
gene id: 9541:PRPF4
uniprot id: A0A2K5X3L9
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:HOXB13
gene id: 9541:HOXB13
uniprot id: A0A2K5WY17
uniprot id: G7PU80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:LOC102135243
gene id: 9541:LOC102135243
uniprot id: A0A2K5ULA2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9541:CYP1A2
gene id: 9541:CYP1A2
uniprot id: O77809
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.
messages: Belongs to the cytochrome P450 family.
messages: By 3-methylcholanthrene (3MC).
messages: Endoplasmic reticulum membrane
messages: Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
messages: Liver.
messages: Microsome membrane

9541:BMPR2
gene id: 9541:BMPR2
uniprot id: A0A2K5V0S9
uniprot id: A0A2K5V0T2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9541:TCL1B
gene id: 9541:TCL1B
uniprot id: G7PBF1
names: Similarity
messages: Belongs to the TCL1 family.

9541:MRPL54
gene id: 9541:MRPL54
uniprot id: A0A2K5W963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9541:RBPMS2
gene id: 9541:RBPMS2
uniprot id: A0A2K5VT66
names: Subcellular Location Annotation
messages: Cytoplasm

9541:RGS2
gene id: 9541:RGS2
uniprot id: A0A8J8Y2I1
uniprot id: G7NXE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9541:EIF2B2
gene id: 9541:EIF2B2
uniprot id: I7GK81
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9541:UBE2A
gene id: 9541:UBE2A
uniprot id: A0A2K5X700
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:AP3D1
gene id: 9541:AP3D1
uniprot id: A0A2K5V773
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

9541:WNT7A
gene id: 9541:WNT7A
uniprot id: G7NYG1
uniprot id: Q1KYK9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
messages: extracellular matrix

9541:IFT122
gene id: 9541:IFT122
uniprot id: A0A2K5URI3
uniprot id: A0A2K5URK0
names: Subcellular Location Annotation
messages: cilium

9541:PBX1
gene id: 9541:PBX1
uniprot id: A0A2K5TYY0
uniprot id: A0A2K5TYY4
uniprot id: A0A2K5TYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9541:CPZ
gene id: 9541:CPZ
uniprot id: A0A2K5WQF9
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TSFM
gene id: 9541:TSFM
uniprot id: A0A2K5U4N6
uniprot id: A0A2K5U4Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9541:PGLYRP2
gene id: 9541:PGLYRP2
uniprot id: A0A2K5UJ61
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9541:TTC29
gene id: 9541:TTC29
uniprot id: Q4R6M4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.
messages: The TPR repeats are required for proper localization into the axoneme and proper function in flagella beating and motility.
messages: flagellum axoneme

9541:GPX5
gene id: 9541:GPX5
uniprot id: A0A2K5WDB5
uniprot id: G7P3T2
uniprot id: P28714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Epididymis.
messages: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
messages: Secreted

9541:CLCNKB
gene id: 9541:CLCNKB
uniprot id: A0A2K5V6E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:HYI
gene id: 9541:HYI
uniprot id: A0A2K5VFE9
uniprot id: A0A2K5VFF2
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9541:KRT222
gene id: 9541:KRT222
uniprot id: A0A8J8YLD5
uniprot id: G7PUP3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MMP14
gene id: 9541:MMP14
uniprot id: A0A8J8XW92
uniprot id: G7P9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

9541:CCHCR1
gene id: 9541:CCHCR1
uniprot id: A0A2K5WSC6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9541:LSM6
gene id: 9541:LSM6
uniprot id: A0A2K5V611
uniprot id: G8F3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9541:PAH
gene id: 9541:PAH
uniprot id: A0A2K5W2M4
uniprot id: G7PJC2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9541:DDX49
gene id: 9541:DDX49
uniprot id: A0A2K5VP37
uniprot id: G7PX05
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:LRP2BP
gene id: 9541:LRP2BP
uniprot id: Q4R3N2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with LRP2.
messages: May act as an adapter that regulates LRP2 function.

9541:PHGDH
gene id: 9541:PHGDH
uniprot id: A0A158SIP3
uniprot id: Q60HD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
messages: Homotetramer.

9541:KCNS2
gene id: 9541:KCNS2
uniprot id: A0A2K5UQH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:FSHB
gene id: 9541:FSHB
uniprot id: G7PQH7
uniprot id: Q6EV79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:10612425). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity).

9541:RPN1
gene id: 9541:RPN1
uniprot id: Q4R4T0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Melanosome
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9541:UBL4A
gene id: 9541:UBL4A
uniprot id: A0A7N9CJ55
names: Subcellular Location Annotation
messages: cytosol

9541:CLDN4
gene id: 9541:CLDN4
uniprot id: A0A2K5UJH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:SNRPA1
gene id: 9541:SNRPA1
uniprot id: G7P9K0
uniprot id: Q4R8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Identified in the spliceosome B complex. Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B. Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.
messages: Nucleus

9541:MARK2
gene id: 9541:MARK2
uniprot id: A0A2K5V4F5
uniprot id: A0A2K5V4G4
uniprot id: A0A2K5V4J1
uniprot id: A0A2K5V4L6
uniprot id: A0A7N9DD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9541:RBM47
gene id: 9541:RBM47
uniprot id: A0A2K5WK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9541:HEATR1
gene id: 9541:HEATR1
uniprot id: A0A2K5VP80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9541:HCRTR2
gene id: 9541:HCRTR2
uniprot id: A0A2K5WVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LAMTOR3
gene id: 9541:LAMTOR3
uniprot id: A0A2K5WHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9541:PTPRM
gene id: 9541:PTPRM
uniprot id: A0A2K5U181
uniprot id: A0A2K5U1C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9541:CMC2
gene id: 9541:CMC2
uniprot id: A0A8J8XBQ7
uniprot id: G7PZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9541:PNPLA1
gene id: 9541:PNPLA1
uniprot id: A0A2K5U414
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:METTL16
gene id: 9541:METTL16
uniprot id: A0A2K5WNT6
uniprot id: Q4R9F9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

9541:ARSJ
gene id: 9541:ARSJ
uniprot id: A0A2K5UI24
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:ZFP69B
gene id: 9541:ZFP69B
uniprot id: A0A2K5VHX0
uniprot id: G7NUD5
names: Subcellular Location Annotation
messages: Nucleus

9541:NXF1
gene id: 9541:NXF1
uniprot id: A0A2K5VTK3
uniprot id: A0A2K5VTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9541:ACTR10
gene id: 9541:ACTR10
uniprot id: A0A2K5UFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9541:SLC15A5
gene id: 9541:SLC15A5
uniprot id: A0A2K5X7S5
uniprot id: G7PJY9
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9541:RAD21
gene id: 9541:RAD21
uniprot id: A0A2K5V3E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9541:CBX2
gene id: 9541:CBX2
uniprot id: A0A7N9CZ26
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC6A8
gene id: 9541:SLC6A8
uniprot id: A0A2K5UZP2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

9541:BEST1
gene id: 9541:BEST1
uniprot id: A0A2K5V6P4
uniprot id: Q6UY87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity).
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane
messages: Phosphorylated by PP2A.
messages: Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity).

9541:YME1L1
gene id: 9541:YME1L1
uniprot id: Q4R4Z4
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9541:TMC8
gene id: 9541:TMC8
uniprot id: A0A2K5X732
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9541:LOC102118666
gene id: 9541:LOC102118666
uniprot id: A0A2K5WVT5
names: Similarity
messages: Belongs to the FAM25 family.

9541:TNS2
gene id: 9541:TNS2
uniprot id: A0A2K5V1T3
names: Subcellular Location Annotation
messages: focal adhesion

9541:LOC102117998
gene id: 9541:LOC102117998
uniprot id: A0A2K5UJT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KIF18A
gene id: 9541:KIF18A
uniprot id: A0A2K5TYW8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:TOX4
gene id: 9541:TOX4
uniprot id: A0A2K5VQH0
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM220A
gene id: 9541:FAM220A
uniprot id: Q4R3X9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with STAT3.
messages: May negatively regulate STAT3.
messages: Nucleus

9541:KIF19
gene id: 9541:KIF19
uniprot id: A0A2K5UCS6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:XPA
gene id: 9541:XPA
uniprot id: A0A2K5TWB0
uniprot id: G7PRW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9541:MVB12B
gene id: 9541:MVB12B
uniprot id: A0A2K5WF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:CYP7B1
gene id: 9541:CYP7B1
uniprot id: A0A2K5UFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9541:GREM1
gene id: 9541:GREM1
uniprot id: A0A7N9DCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9541:RTN3
gene id: 9541:RTN3
uniprot id: A0A2K5UPJ0
uniprot id: A0A2K5UPK0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:DCAF12
gene id: 9541:DCAF12
uniprot id: Q4R3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF12 family.
messages: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF12 and RBX1.
messages: Cytoplasm
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy.
messages: centrosome

9541:RAB3GAP1
gene id: 9541:RAB3GAP1
uniprot id: A0A2K5UK30
uniprot id: A0A2K5UK56
uniprot id: A0A2K5UK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9541:FAM174B
gene id: 9541:FAM174B
uniprot id: A0A2K5U0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:RPS24
gene id: 9541:RPS24
uniprot id: A0A2K5WI52
uniprot id: A0A2K5WI69
uniprot id: A0A2K5WTC9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9541:BSCL2
gene id: 9541:BSCL2
uniprot id: A0A2K5UTB2
uniprot id: Q4R5X7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:MTCL1
gene id: 9541:MTCL1
uniprot id: A0A2K5VKQ5
names: Similarity
messages: Belongs to the SOGA family.

9541:STX5
gene id: 9541:STX5
uniprot id: A0A8J8XE24
uniprot id: G7PPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9541:ADIPOR2
gene id: 9541:ADIPOR2
uniprot id: A0A2K5TJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:SPRR1B
gene id: 9541:SPRR1B
uniprot id: G7NUF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9541:TM9SF2
gene id: 9541:TM9SF2
uniprot id: A0A2K5VMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:NUF2
gene id: 9541:NUF2
uniprot id: A0A8J8YDP9
uniprot id: G7NU22
names: Similarity
messages: Belongs to the NUF2 family.

9541:CDC45
gene id: 9541:CDC45
uniprot id: A0A2K5WQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9541:HCAR1
gene id: 9541:HCAR1
uniprot id: A0A2K5ULI6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CHCHD7
gene id: 9541:CHCHD7
uniprot id: Q8SPI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHCHD7 family.
messages: Mitochondrion intermembrane space
messages: Monomer.

9541:LOC102136717
gene id: 9541:LOC102136717
uniprot id: A0A7N9CT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9541:EDC3
gene id: 9541:EDC3
uniprot id: A0A2K5VDI2
uniprot id: G7P942
uniprot id: Q4R8V9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EDC3 family.
messages: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
messages: Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36.
messages: P-body
messages: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity).

9541:MAD1L1
gene id: 9541:MAD1L1
uniprot id: A0A2K5WQN7
uniprot id: A0A2K5WQR5
names: Similarity
messages: Belongs to the MAD1 family.

9541:C6H5orf22
gene id: 9541:C6H5orf22
uniprot id: A0A2K5UT40
uniprot id: G7P7B1
uniprot id: I7GH47
names: Similarity
messages: Belongs to the UPF0489 family.

9541:PPIE
gene id: 9541:PPIE
uniprot id: Q4R675
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9541:TLL1
gene id: 9541:TLL1
uniprot id: A0A2K5U8M4
uniprot id: A0A2K5U8R3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PNPO
gene id: 9541:PNPO
uniprot id: A0A2K5X2W4
uniprot id: Q4R6R7
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9541:DLGAP4
gene id: 9541:DLGAP4
uniprot id: A0A2K5V1A5
uniprot id: A0A2K5V1B3
uniprot id: A0A2K5V1F4
uniprot id: A0A2K5V1M5
names: Similarity
messages: Belongs to the SAPAP family.

9541:PHETA2
gene id: 9541:PHETA2
uniprot id: G7PFP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9541:TRIP13
gene id: 9541:TRIP13
uniprot id: A0A2K5WCI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9541:PTPN4
gene id: 9541:PTPN4
uniprot id: A0A2K5W4U0
uniprot id: G7PN58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9541:TNFSF12
gene id: 9541:TNFSF12
uniprot id: A0A2K5TX74
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:STOML3
gene id: 9541:STOML3
uniprot id: A0A2K5TSK0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9541:NRG4
gene id: 9541:NRG4
uniprot id: A0A2K5TJ77
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PARK7
gene id: 9541:PARK7
uniprot id: A0A2K5VXS5
uniprot id: A0A2K5VY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9541:MC4R
gene id: 9541:MC4R
uniprot id: Q8HXX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ATRNL1. Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production (By similarity). Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP (By similarity).
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9541:TMCO5A
gene id: 9541:TMCO5A
uniprot id: A0A2K5VS67
uniprot id: A0A2K5VSG9
names: Subcellular Location Annotation
messages: Membrane

9541:CRYGN
gene id: 9541:CRYGN
uniprot id: A0A2K5VIL8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:SIX1
gene id: 9541:SIX1
uniprot id: A0A2K5V3Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9541:CREB3L2
gene id: 9541:CREB3L2
uniprot id: A0A2K5VAS0
uniprot id: G8F420
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:MRPS6
gene id: 9541:MRPS6
uniprot id: I7G7W8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

9541:THTPA
gene id: 9541:THTPA
uniprot id: A0A2K5VF89
uniprot id: G7P9W2
uniprot id: Q9BGW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9541:NPY1R
gene id: 9541:NPY1R
uniprot id: A0A2K5U9D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GAPDH
gene id: 9541:GAPDH
uniprot id: A0A0A7KUP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9541:PRPF31
gene id: 9541:PRPF31
uniprot id: A0A2K5U8Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9541:FABP6
gene id: 9541:FABP6
uniprot id: A0A2K5TX64
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:DTX4
gene id: 9541:DTX4
uniprot id: A0A2K5WWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9541:TSHZ3
gene id: 9541:TSHZ3
uniprot id: A0A2K5TL77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9541:POU2F2
gene id: 9541:POU2F2
uniprot id: A0A2K5UQU2
uniprot id: A0A2K5UQU5
uniprot id: A0A7N9D5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9541:RETREG1
gene id: 9541:RETREG1
uniprot id: A0A2K5UGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9541:CCR2
gene id: 9541:CCR2
uniprot id: A0A2K5TRN1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:SULF1
gene id: 9541:SULF1
uniprot id: A0A2K5VH45
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:GMPPB
gene id: 9541:GMPPB
uniprot id: A0A2K5UBH2
uniprot id: G8F4N3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9541:ALDH3B1
gene id: 9541:ALDH3B1
uniprot id: A0A2K5TU20
uniprot id: A0A7N9CJD7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:NGRN
gene id: 9541:NGRN
uniprot id: A0A2K5VCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9541:JAK2
gene id: 9541:JAK2
uniprot id: A0A2K5WBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Nucleus

9541:TSPAN9
gene id: 9541:TSPAN9
uniprot id: A0A2K5VDR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PNLIPRP3
gene id: 9541:PNLIPRP3
uniprot id: A0A2K5URK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:OSBPL7
gene id: 9541:OSBPL7
uniprot id: A0A2K5TT73
uniprot id: A0A2K5U737
uniprot id: G7PU60
names: Similarity
messages: Belongs to the OSBP family.

9541:LOC101866604
gene id: 9541:LOC101866604
uniprot id: I7G5Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:HPCAL4
gene id: 9541:HPCAL4
uniprot id: A0A8J8YKT1
uniprot id: G7NUC4
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9541:PAIP2B
gene id: 9541:PAIP2B
uniprot id: A0A2K5UKQ6
names: Similarity
messages: Belongs to the PAIP2 family.

9541:MCM6
gene id: 9541:MCM6
uniprot id: Q4R6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9541:SLC27A4
gene id: 9541:SLC27A4
uniprot id: A0A2K5V2T4
uniprot id: Q4R3Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Endoplasmic reticulum membrane
messages: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

9541:MYO18A
gene id: 9541:MYO18A
uniprot id: A0A2K5W884
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TM9SF4
gene id: 9541:TM9SF4
uniprot id: A0A2K5WM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:NAT10
gene id: 9541:NAT10
uniprot id: A0A2K5U6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9541:GOLM2
gene id: 9541:GOLM2
uniprot id: A0A2K5UP08
uniprot id: A0A2K5UP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9541:TCTN1
gene id: 9541:TCTN1
uniprot id: A0A2K5WTE9
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9541:MCIDAS
gene id: 9541:MCIDAS
uniprot id: A0A7N9DC94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9541:CZIB
gene id: 9541:CZIB
uniprot id: A0A2K5U234
names: Similarity
messages: Belongs to the UPF0587 family.

9541:TUT4
gene id: 9541:TUT4
uniprot id: A0A2K5UFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9541:G6PC3
gene id: 9541:G6PC3
uniprot id: A0A2K5U8S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9541:RBL1
gene id: 9541:RBL1
uniprot id: A0A2K5URJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9541:TDRD9
gene id: 9541:TDRD9
uniprot id: G7PBQ1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

9541:PRKCH
gene id: 9541:PRKCH
uniprot id: A0A2K5UP58
uniprot id: G7PAH0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9541:MMP20
gene id: 9541:MMP20
uniprot id: A0A2K5TT27
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:LOC102124821
gene id: 9541:LOC102124821
uniprot id: A0A2K5UE97
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:CPNE2
gene id: 9541:CPNE2
uniprot id: A0A2K5VBZ5
uniprot id: A0A7N9CK79
names: Similarity
messages: Belongs to the copine family.

9541:RPS16
gene id: 9541:RPS16
uniprot id: A0A2K5WRP5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9541:PAQR4
gene id: 9541:PAQR4
uniprot id: A0A2K5WRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:ANAPC15
gene id: 9541:ANAPC15
uniprot id: A0A2K5W3R7
uniprot id: G7PR12
names: Similarity
messages: Belongs to the APC15 family.

9541:WDR35
gene id: 9541:WDR35
uniprot id: A0A2K5WG25
uniprot id: A0A2K5WG69
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9541:TSNAX
gene id: 9541:TSNAX
uniprot id: Q4R599
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).
messages: Belongs to the translin family.
messages: Golgi apparatus
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).
messages: Sumoylated with SUMO1.
messages: perinuclear region

9541:GLB1L2
gene id: 9541:GLB1L2
uniprot id: A0A2K5VQ58
uniprot id: A0A2K5VQ85
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9541:UPF3A
gene id: 9541:UPF3A
uniprot id: Q4R3M2
names: Similarity
messages: Belongs to the RENT3 family.

9541:SLC2A7
gene id: 9541:SLC2A7
uniprot id: A0A2K5WT05
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9541:GPR3
gene id: 9541:GPR3
uniprot id: A0A2K5UKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SPG7
gene id: 9541:SPG7
uniprot id: A0A2K5U7I5
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9541:BAP1
gene id: 9541:BAP1
uniprot id: A0A8J8YI92
uniprot id: G7NZW2
names: Similarity
messages: Belongs to the peptidase C12 family.

9541:NKAIN4
gene id: 9541:NKAIN4
uniprot id: A0A2K5W869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9541:LOC102125546
gene id: 9541:LOC102125546
uniprot id: A0A2K5WB59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:B3GNT7
gene id: 9541:B3GNT7
uniprot id: A0A2K5V5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:DKK1
gene id: 9541:DKK1
uniprot id: A0A2K5WMC3
uniprot id: A0A7N9IE82
names: Similarity
messages: Belongs to the dickkopf family.

9541:C3AR1
gene id: 9541:C3AR1
uniprot id: A0A7N9IBB4
uniprot id: Q6TAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21 (By similarity).
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9541:ITGA4
gene id: 9541:ITGA4
uniprot id: A0A2K5U6S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:TOM1
gene id: 9541:TOM1
uniprot id: A0A2K5W6K2
uniprot id: A0A7N9IGN3
uniprot id: G7PFA5
names: Similarity
messages: Belongs to the TOM1 family.

9541:KRT20
gene id: 9541:KRT20
uniprot id: A0A8J8Y4V1
uniprot id: G7PUQ1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102147203
gene id: 9541:LOC102147203
uniprot id: A0A2K5WYP0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:FGF16
gene id: 9541:FGF16
uniprot id: A0A2K5VMM2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:TMED5
gene id: 9541:TMED5
uniprot id: A0A2K5TJL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9541:ENPP1
gene id: 9541:ENPP1
uniprot id: A0A2K5WPZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9541:OPRM1
gene id: 9541:OPRM1
uniprot id: A0A2K5U0J7
uniprot id: A0A2K5U0S6
uniprot id: Q95M54
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (By similarity). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1.
messages: Membrane
messages: Perikaryon
messages: Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).
messages: Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a bet…
messages: Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
messages: axon
messages: dendrite

9541:CUL7
gene id: 9541:CUL7
uniprot id: A0A2K5WSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9541:PFKFB4
gene id: 9541:PFKFB4
uniprot id: Q4R8B6
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.
messages: The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.

9541:CORO6
gene id: 9541:CORO6
uniprot id: A0A2K5VCX6
uniprot id: A0A2K5VCY7
uniprot id: A0A2K5VD52
names: Similarity
messages: Belongs to the WD repeat coronin family.

9541:ALDH1A3
gene id: 9541:ALDH1A3
uniprot id: A0A2K5VVJ1
uniprot id: A0A2K5VVS6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:RDM1
gene id: 9541:RDM1
uniprot id: Q4R856
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: C-terminal half contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.
messages: Cajal body
messages: Cytoplasm
messages: Homodimer.
messages: May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).
messages: Nucleus
messages: PML body
messages: nucleolus

9541:STS
gene id: 9541:STS
uniprot id: Q2XQY2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:LOC102121655
gene id: 9541:LOC102121655
uniprot id: A0A7N9CXZ7
names: Similarity
messages: Belongs to the actin family.

9541:CYP21A2
gene id: 9541:CYP21A2
uniprot id: A0A2K5TZ97
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:TNFRSF19
gene id: 9541:TNFRSF19
uniprot id: A0A2K5UDZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:BHMT
gene id: 9541:BHMT
uniprot id: A0A8J8YGY7
uniprot id: G7P7U0
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9541:C10H20orf27
gene id: 9541:C10H20orf27
uniprot id: A0A2K5UJK1
uniprot id: A0A2K5UJP1
uniprot id: G7PGV4
uniprot id: I7GL62
names: Similarity
messages: Belongs to the UPF0687 family.

9541:VANGL1
gene id: 9541:VANGL1
uniprot id: A0A2K5UAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9541:SQLE
gene id: 9541:SQLE
uniprot id: Q2PFM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9541:C1S
gene id: 9541:C1S
uniprot id: A0A2K5VQX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102125235
gene id: 9541:LOC102125235
uniprot id: A0A2K5VGG3
names: Similarity
messages: Belongs to the SPAN-X family.

9541:RAD51
gene id: 9541:RAD51
uniprot id: A0A2K5VN96
uniprot id: A0A2K5VNC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9541:KCNQ5
gene id: 9541:KCNQ5
uniprot id: A0A2K5W4T1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:SLC6A13
gene id: 9541:SLC6A13
uniprot id: A0A2K5TN47
uniprot id: G7PJJ2
uniprot id: Q2PG55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (By similarity). Can also mediate transport of beta-alanine, taurine and hypotaurine (By similarity).
messages: Membrane

9541:KDM1B
gene id: 9541:KDM1B
uniprot id: A0A2K5W5G6
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9541:SNRPA
gene id: 9541:SNRPA
uniprot id: G7PXM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9541:GRIA3
gene id: 9541:GRIA3
uniprot id: A0A2K5UF45
uniprot id: A0A2K5UF55
uniprot id: A0A2K5UFB7
uniprot id: A0A8J8YCD6
uniprot id: G7Q3M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:ITFG1
gene id: 9541:ITFG1
uniprot id: A0A2K5WMQ9
names: Similarity
messages: Belongs to the TIP family.

9541:TUT1
gene id: 9541:TUT1
uniprot id: A0A2K5UA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

9541:TPH2
gene id: 9541:TPH2
uniprot id: A0A2K5VAQ7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9541:LOC102141433
gene id: 9541:LOC102141433
uniprot id: A0A7N9DET8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:SUV39H2
gene id: 9541:SUV39H2
uniprot id: A0A2K5UW31
uniprot id: A0A2K5UW32
uniprot id: Q4R3E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex (By similarity).
messages: Nucleus
messages: centromere

9541:NKD1
gene id: 9541:NKD1
uniprot id: A0A2K5VNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9541:SLC16A6
gene id: 9541:SLC16A6
uniprot id: A0A8J8XB19
uniprot id: G7PV86
names: Subcellular Location Annotation
messages: Membrane

9541:RGS5
gene id: 9541:RGS5
uniprot id: Q4R5E0
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9541:SCOC
gene id: 9541:SCOC
uniprot id: A0A2K5TUE0
uniprot id: A0A7N9CUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9541:OSGEPL1
gene id: 9541:OSGEPL1
uniprot id: A0A2K5UXY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9541:GNB4
gene id: 9541:GNB4
uniprot id: A0A2K5WWG1
uniprot id: G7NZ30
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9541:SELL
gene id: 9541:SELL
uniprot id: A0A2K5W1G2
uniprot id: A0A7N9DE02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:DPY30
gene id: 9541:DPY30
uniprot id: A0A2K5VRJ2
uniprot id: G7PLZ5
names: Similarity
messages: Belongs to the dpy-30 family.

9541:LRRFIP1
gene id: 9541:LRRFIP1
uniprot id: A0A2K5VBU9
uniprot id: A0A2K5VBV9
names: Similarity
messages: Belongs to the LRRFIP family.

9541:TNFRSF10B
gene id: 9541:TNFRSF10B
uniprot id: A0A2K5TXJ8
uniprot id: A0A2K5TXK0
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9541:NKX2-6
gene id: 9541:NKX2-6
uniprot id: A0A2K5WZW6
names: Subcellular Location Annotation
messages: Nucleus

9541:ERH
gene id: 9541:ERH
uniprot id: A0A2K5U2F3
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9541:CTSC
gene id: 9541:CTSC
uniprot id: Q60HG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
messages: Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity).

9541:CLUAP1
gene id: 9541:CLUAP1
uniprot id: A0A2K5W5E5
uniprot id: G7Q0C9
uniprot id: Q4R6Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLUAP1 family.
messages: Interacts with CLU/clusterin. Interacts with UBXN10; the interaction is direct.
messages: Nucleus
messages: Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.
messages: cilium

9541:SND1
gene id: 9541:SND1
uniprot id: A0A2K5WL07
uniprot id: A0A8J8XDP7
uniprot id: G7P0L2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9541:TAS2R41
gene id: 9541:TAS2R41
uniprot id: G7P1I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:SDF4
gene id: 9541:SDF4
uniprot id: A0A2K5X223
uniprot id: Q4R585
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Binds calcium via its EF-hands.
messages: Golgi apparatus lumen
messages: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

9541:SUFU
gene id: 9541:SUFU
uniprot id: A0A2K5WNJ5
uniprot id: G7PDV2
uniprot id: Q4R7F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9541:PTAFR
gene id: 9541:PTAFR
uniprot id: A0A2K5UPJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9541:DDX54
gene id: 9541:DDX54
uniprot id: A0A2K5VH50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9541:LOC102136451
gene id: 9541:LOC102136451
uniprot id: A0A2K5WH85
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.

9541:IRF9
gene id: 9541:IRF9
uniprot id: A0A2K5U899
uniprot id: I7GLB4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:LOC102116945
gene id: 9541:LOC102116945
uniprot id: A0A2K5UJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9541:CPM
gene id: 9541:CPM
uniprot id: A0A2K5TSF2
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:THRA
gene id: 9541:THRA
uniprot id: I7GJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:LOC102143773
gene id: 9541:LOC102143773
uniprot id: A0A2K5V0I8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9541:CLDND1
gene id: 9541:CLDND1
uniprot id: Q4R4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:TRAPPC13
gene id: 9541:TRAPPC13
uniprot id: A0A2K5X667
uniprot id: A0A2K5X6A3
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9541:P3H1
gene id: 9541:P3H1
uniprot id: A0A2K5U6Q6
names: Similarity
messages: Belongs to the leprecan family.

9541:SLC25A3
gene id: 9541:SLC25A3
uniprot id: A0A2K5U6E8
uniprot id: I7G9S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ADRB1
gene id: 9541:ADRB1
uniprot id: U6BY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:UIMC1
gene id: 9541:UIMC1
uniprot id: A0A2K5WPE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9541:ECI1
gene id: 9541:ECI1
uniprot id: A0A2K5TTI7
uniprot id: A0A2K5TTJ3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:HOXC8
gene id: 9541:HOXC8
uniprot id: A0A8J8Y903
uniprot id: G7PHW1
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC7A1
gene id: 9541:SLC7A1
uniprot id: A0A8J8XU70
uniprot id: G7PVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:LOC102118946
gene id: 9541:LOC102118946
uniprot id: A0A7N9DA28
uniprot id: Q95K74
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.
messages: Membrane
messages: O-glycosylation at Thr-140 is essential for recognition by PILRA.

9541:DBNL
gene id: 9541:DBNL
uniprot id: I7GJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

9541:KYNU
gene id: 9541:KYNU
uniprot id: A0A2K5WUC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PUF60
gene id: 9541:PUF60
uniprot id: A0A2K5VFX0
uniprot id: A0A2K5VG32
uniprot id: A0A2K5VG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9541:XPC
gene id: 9541:XPC
uniprot id: A0A2K5UY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9541:MIF
gene id: 9541:MIF
uniprot id: Q4R549
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).
messages: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
messages: Secreted

9541:NGB
gene id: 9541:NGB
uniprot id: A0A7N9CWQ6
names: Similarity
messages: Belongs to the globin family.

9541:ARV1
gene id: 9541:ARV1
uniprot id: A0A8J8YFP4
uniprot id: G7NXK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9541:TMEM245
gene id: 9541:TMEM245
uniprot id: A0A2K5UKF6
uniprot id: A0A7N9IC78
uniprot id: A0A7N9ICT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9541:PRMT5
gene id: 9541:PRMT5
uniprot id: A0A2K5U736
uniprot id: A0A2K5U799
uniprot id: A0A2K5U7A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9541:ALDH4A1
gene id: 9541:ALDH4A1
uniprot id: A0A2K5U6Q8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:FAM199X
gene id: 9541:FAM199X
uniprot id: A0A2K5X7I9
names: Similarity
messages: Belongs to the FAM199 family.

9541:TRMT11
gene id: 9541:TRMT11
uniprot id: A0A2K5WYZ9
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9541:LOC102132662
gene id: 9541:LOC102132662
uniprot id: F8RBU3
names: Similarity
messages: Belongs to the MHC class II family.

9541:DDX28
gene id: 9541:DDX28
uniprot id: Q4R4T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family.
messages: Mitochondrion
messages: Mitosome matrix
messages: Monomer. Found in a complex with GRSF1, DHX30, FASTKD2 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA) and with the mitochondrial ribosome large subunit (39S).
messages: Nucleus
messages: Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity).
messages: mitochondrion nucleoid

9541:LCA5
gene id: 9541:LCA5
uniprot id: A0A2K5X6G4
names: Similarity
messages: Belongs to the LCA5 family.

9541:ATP5MG
gene id: 9541:ATP5MG
uniprot id: A0A2K5WDC2
uniprot id: A0A7N9DCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9541:COPE
gene id: 9541:COPE
uniprot id: A0A2K5WQ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9541:SDHAF4
gene id: 9541:SDHAF4
uniprot id: A0A8J8YBD7
uniprot id: G7P2Z8
names: Similarity
messages: Belongs to the SDHAF4 family.

9541:LOC102133057
gene id: 9541:LOC102133057
uniprot id: A0A2K5UN81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LASP1
gene id: 9541:LASP1
uniprot id: A0A2K5TJN2
uniprot id: A0A7N9IBC7
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9541:IRX6
gene id: 9541:IRX6
uniprot id: A0A2K5WRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9541:RIBC2
gene id: 9541:RIBC2
uniprot id: Q4R9D8
names: Similarity
messages: Belongs to the RIB43A family.

9541:CYP2A24
gene id: 9541:CYP2A24
uniprot id: A8CBQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:LOC102125891
gene id: 9541:LOC102125891
uniprot id: A0A2K5X524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LGI3
gene id: 9541:LGI3
uniprot id: Q4R4H3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with STX1A.
messages: May participate in the regulation of neuronal exocytosis.
messages: Secreted
messages: synaptic vesicle
messages: synaptosome

9541:SFXN4
gene id: 9541:SFXN4
uniprot id: A0A2K5VDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9541:PLA2G12A
gene id: 9541:PLA2G12A
uniprot id: A0A2K5TPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9541:PLOD2
gene id: 9541:PLOD2
uniprot id: A0A2K5WMG9
uniprot id: A0A2K5WMI3
uniprot id: A0A2K5WMZ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:THOC6
gene id: 9541:THOC6
uniprot id: A0A8J8XWH0
uniprot id: G7Q0B3
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9541:BMP7
gene id: 9541:BMP7
uniprot id: A0A2K5V0V5
names: Similarity
messages: Belongs to the TGF-beta family.

9541:TCN2
gene id: 9541:TCN2
uniprot id: A0A2K5WSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9541:CNN3
gene id: 9541:CNN3
uniprot id: A0A2K5VIP8
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9541:IREB2
gene id: 9541:IREB2
uniprot id: A0A2K5X545
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9541:EHD4
gene id: 9541:EHD4
uniprot id: A0A7N9DAY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9541:CD9
gene id: 9541:CD9
uniprot id: A0A2K5WGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9541:SESN1
gene id: 9541:SESN1
uniprot id: A0A8J8XG88
uniprot id: Q4R6P7
uniprot id: Q4R7Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sestrin family.
messages: Cytoplasm
messages: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
messages: Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1. May interact with PRDX1.
messages: Nucleus
messages: The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling.
messages: The N-terminal domain may have an alkylhydroperoxide reductase activity.

9541:FLT4
gene id: 9541:FLT4
uniprot id: A0A2K5X6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9541:SETDB2
gene id: 9541:SETDB2
uniprot id: A0A2K5V3M8
uniprot id: G7PVE8
names: Subcellular Location Annotation
messages: Chromosome

9541:LOC102140578
gene id: 9541:LOC102140578
uniprot id: A0A2K5X4Q6
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102127615
gene id: 9541:LOC102127615
uniprot id: A0A2K5UNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SLC13A1
gene id: 9541:SLC13A1
uniprot id: A0A8J8Y2D1
uniprot id: G7P0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:TM7SF2
gene id: 9541:TM7SF2
uniprot id: I7GPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9541:GPRC5B
gene id: 9541:GPRC5B
uniprot id: I7GMR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:ACTL7B
gene id: 9541:ACTL7B
uniprot id: Q95JK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9541:SSTR1
gene id: 9541:SSTR1
uniprot id: A0A2K5UEB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:POPDC2
gene id: 9541:POPDC2
uniprot id: A0A2K5WX81
uniprot id: A0A2K5WX93
uniprot id: A0A2K5WXT7
names: Similarity
messages: Belongs to the popeye family.

9541:LOC102134176
gene id: 9541:LOC102134176
uniprot id: Q9TSM6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
messages: Homotrimer. Interacts with ATF5 and tubulin (By similarity).
messages: In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).
messages: Inhibited by sodium orthovanadate and pentamidine.
messages: Nucleus
messages: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
messages: spindle

9541:TOP3A
gene id: 9541:TOP3A
uniprot id: A0A2K5VKN3
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9541:NR1H2
gene id: 9541:NR1H2
uniprot id: A0A2K5X889
uniprot id: A0A2K5X8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:SLC15A4
gene id: 9541:SLC15A4
uniprot id: A0A2K5X3W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9541:MAP1LC3A
gene id: 9541:MAP1LC3A
uniprot id: I7GLL6
names: Similarity
messages: Belongs to the ATG8 family.

9541:MAML3
gene id: 9541:MAML3
uniprot id: A0A2K5VM51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9541:SEPTIN7
gene id: 9541:SEPTIN7
uniprot id: Q4R521
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9541:ASB8
gene id: 9541:ASB8
uniprot id: A0A8J8XBK7
uniprot id: G7PHQ2
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9541:RABGGTB
gene id: 9541:RABGGTB
uniprot id: A0A2K5WEG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9541:ODF2
gene id: 9541:ODF2
uniprot id: A0A2K5TUM7
uniprot id: A0A2K5TUQ3
uniprot id: A0A2K5TUY9
uniprot id: G7PRF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9541:APOC2
gene id: 9541:APOC2
uniprot id: A2V9Y5
uniprot id: P18658
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9541:PPP3R2
gene id: 9541:PPP3R2
uniprot id: Q4R8E1
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9541:FKTN
gene id: 9541:FKTN
uniprot id: A0A2K5VBG3
uniprot id: A0A7N9D6T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9541:CHURC1
gene id: 9541:CHURC1
uniprot id: A0A2K5WSH3
names: Similarity
messages: Belongs to the Churchill family.

9541:KDM5B
gene id: 9541:KDM5B
uniprot id: A0A2K5UHD5
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9541:NDUFA11
gene id: 9541:NDUFA11
uniprot id: I7G4S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:CLUL1
gene id: 9541:CLUL1
uniprot id: A0A7N9CZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

9541:CCT8
gene id: 9541:CCT8
uniprot id: A0A2K5VA28
uniprot id: Q4R5J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm
messages: centrosome
messages: cilium basal body

9541:OPRL1
gene id: 9541:OPRL1
uniprot id: A0A2K5TWS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9541:GLIPR1
gene id: 9541:GLIPR1
uniprot id: I7GIK2
names: Similarity
messages: Belongs to the CRISP family.

9541:CA7
gene id: 9541:CA7
uniprot id: A0A2K5U255
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:TNFAIP6
gene id: 9541:TNFAIP6
uniprot id: A0A8J8XIV1
uniprot id: G7PKK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CCND1
gene id: 9541:CCND1
uniprot id: A0A2K5TKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9541:RNASEH2A
gene id: 9541:RNASEH2A
uniprot id: A0A2K5TX28
uniprot id: A0A7N9IAX6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9541:LOC102137778
gene id: 9541:LOC102137778
uniprot id: A0A2K5UN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SAR1B
gene id: 9541:SAR1B
uniprot id: A0A2K5W6R3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9541:FBXL5
gene id: 9541:FBXL5
uniprot id: A0A2K5VEY4
names: Subcellular Location Annotation
messages: perinuclear region

9541:CCR7
gene id: 9541:CCR7
uniprot id: C0ISS3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:NSMCE4A
gene id: 9541:NSMCE4A
uniprot id: A0A2K5X6C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9541:USP49
gene id: 9541:USP49
uniprot id: A0A2K5VLW2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:TRPC5
gene id: 9541:TRPC5
uniprot id: A0A8J8XXH1
uniprot id: G7Q3H5
names: Subcellular Location Annotation
messages: Membrane

9541:ARRDC4
gene id: 9541:ARRDC4
uniprot id: A0A2K5WR30
names: Similarity
messages: Belongs to the arrestin family.

9541:PTGES3
gene id: 9541:PTGES3
uniprot id: I7GKX7
uniprot id: Q25KC4
uniprot id: Q6PWL5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Detected in granulosa cells of periovulatory follicles. Detected at high levels in lung, and at lower levels in endometrium, ovary, myometrium, oviduct and liver (at protein level). Detected in endometrium, myometrium, oviduct and ovary, and at low levels in liver and lung.
messages: Forms a complex with HSP70, HSP90 and other chaperones.
messages: Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.
messages: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.

9541:SRP14
gene id: 9541:SRP14
uniprot id: Q4R5C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).

9541:SORD
gene id: 9541:SORD
uniprot id: G7PB87
uniprot id: Q4R639
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity).
messages: flagellum

9541:CASS4
gene id: 9541:CASS4
uniprot id: A0A2K5TRI2
uniprot id: A0A2K5TRK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9541:ME2
gene id: 9541:ME2
uniprot id: A0A2K5VDY8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9541:LOC102124928
gene id: 9541:LOC102124928
uniprot id: G7P1K8
uniprot id: Q4W7G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:OSMR
gene id: 9541:OSMR
uniprot id: A0A2K5UFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9541:LOC102139187
gene id: 9541:LOC102139187
uniprot id: A0A2K5U1F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9541:FFAR4
gene id: 9541:FFAR4
uniprot id: C8YUV0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome membrane
messages: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (By similarity). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG se…
messages: Highly expressed in lung and colon.
messages: Interacts (via C-terminus) with ARRB2 following LCFAs stimulation.
messages: Lysosome membrane
messages: Phosphorylated at two clusters of Ser and Thr residues located in the intracellular C-terminus. Prerequisite for FFAR4 internalization via an ARRB2-dependent pathway.
messages: cilium membrane

9541:CXCL6
gene id: 9541:CXCL6
uniprot id: A0A2K5VQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:LOC102127733
gene id: 9541:LOC102127733
uniprot id: A0A2K5UJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SESN3
gene id: 9541:SESN3
uniprot id: A0A2K5WZF6
uniprot id: Q4R751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9541:ESR1
gene id: 9541:ESR1
uniprot id: A0A8J8XH51
uniprot id: G7P4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9541:LOC102122786
gene id: 9541:LOC102122786
uniprot id: A0A2K5UP00
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:C9H10orf53
gene id: 9541:C9H10orf53
uniprot id: A0A2K5VMA8
names: Similarity
messages: Belongs to the UPF0728 family.

9541:CAMK1
gene id: 9541:CAMK1
uniprot id: A0A8J8Y5C5
uniprot id: G7NYU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:ARSI
gene id: 9541:ARSI
uniprot id: A0A2K5WH83
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:CDNF
gene id: 9541:CDNF
uniprot id: A0A8J8YCX8
uniprot id: G7PEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9541:APC
gene id: 9541:APC
uniprot id: A0A2K5WV06
uniprot id: A0A2K5WVD6
uniprot id: A0A2K5WVL8
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9541:GFUS
gene id: 9541:GFUS
uniprot id: A0A2K5VS94
uniprot id: G7PD36
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9541:ZC3H12C
gene id: 9541:ZC3H12C
uniprot id: A0A2K5VXU9
uniprot id: G7PNR6
names: Similarity
messages: Belongs to the ZC3H12 family.

9541:RPS27A
gene id: 9541:RPS27A
uniprot id: Q4R580
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9541:TMC7
gene id: 9541:TMC7
uniprot id: Q4R7U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane
messages: Probable ion channel.

9541:REEP6
gene id: 9541:REEP6
uniprot id: A0A2K5WR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9541:HS3ST2
gene id: 9541:HS3ST2
uniprot id: A0A2K5TNA8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:YWHAQ
gene id: 9541:YWHAQ
uniprot id: A0A7N9DCE6
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9541:RPS29
gene id: 9541:RPS29
uniprot id: A0A2K5WR94
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9541:CLRN1
gene id: 9541:CLRN1
uniprot id: A0A2K5VT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9541:BCL7A
gene id: 9541:BCL7A
uniprot id: A0A2K5VSD8
names: Similarity
messages: Belongs to the BCL7 family.

9541:DEUP1
gene id: 9541:DEUP1
uniprot id: G7PNG4
uniprot id: Q95JK1
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP63 family.
messages: Contaminating sequence. Potential poly-A sequence. The C-terminus was extended based on orthologous sequences.
messages: Cytoplasm
messages: Interacts with CEP152; the interaction is mutually exclusive with CEP63.
messages: Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

9541:GALNT6
gene id: 9541:GALNT6
uniprot id: A0A2K5UX37
uniprot id: G8F487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:RAP2C
gene id: 9541:RAP2C
uniprot id: A0A2K5V0X8
uniprot id: G8F3L7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9541:ANK1
gene id: 9541:ANK1
uniprot id: A0A2K5VRI0
uniprot id: A0A2K5VRS4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:SNX17
gene id: 9541:SNX17
uniprot id: A0A2K5X0R5
uniprot id: A0A8J8YBZ6
uniprot id: G7PLW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9541:LOC102118143
gene id: 9541:LOC102118143
uniprot id: A0A2K5UET7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CCR8
gene id: 9541:CCR8
uniprot id: A0A8J8XUI3
uniprot id: G7NYJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:SLC27A2
gene id: 9541:SLC27A2
uniprot id: A0A2K5X2A2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:TMSB15B
gene id: 9541:TMSB15B
uniprot id: A0A8J8XD17
uniprot id: G7Q3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:ACADM
gene id: 9541:ACADM
uniprot id: A0A2K5V3T1
uniprot id: A0A2K5V3V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9541:CASP5
gene id: 9541:CASP5
uniprot id: A0A2K5U1I1
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:SUPT4H1
gene id: 9541:SUPT4H1
uniprot id: Q4R941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).
messages: Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1 (By similarity).
messages: Nucleus

9541:CHRD
gene id: 9541:CHRD
uniprot id: A0A2K5TVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9541:SHQ1
gene id: 9541:SHQ1
uniprot id: A0A2K5X2F4
names: Similarity
messages: Belongs to the SHQ1 family.

9541:UBXN1
gene id: 9541:UBXN1
uniprot id: A0A2K5VTT1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CRTC3
gene id: 9541:CRTC3
uniprot id: A0A2K5VEH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9541:CASD1
gene id: 9541:CASD1
uniprot id: A0A2K5TX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9541:EPB41
gene id: 9541:EPB41
uniprot id: A0A2K5WV60
uniprot id: A0A2K5WV95
uniprot id: A0A2K5WVN3
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9541:TPK1
gene id: 9541:TPK1
uniprot id: A0A2K5VA75
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9541:DUSP10
gene id: 9541:DUSP10
uniprot id: A0A8J8XX38
uniprot id: G7NTY0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:GNAT2
gene id: 9541:GNAT2
uniprot id: A0A8J8XJM5
uniprot id: G7NW35
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:TREM1
gene id: 9541:TREM1
uniprot id: A0A2K5VHG8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:LOC102141029
gene id: 9541:LOC102141029
uniprot id: A0A2K5UG77
uniprot id: G7PVW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:MCOLN2
gene id: 9541:MCOLN2
uniprot id: A0A2K5UUX9
uniprot id: A0A7N9CSJ3
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9541:OGDH
gene id: 9541:OGDH
uniprot id: A0A2K5VYC4
uniprot id: A0A2K5VYI5
uniprot id: A0A2K5VYM0
uniprot id: A0A2K5VYN1
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9541:ATAD2
gene id: 9541:ATAD2
uniprot id: A0A2K5UHI4
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:DRAM1
gene id: 9541:DRAM1
uniprot id: A0A2K5W012
uniprot id: G7PJB5
names: Subcellular Location Annotation
messages: Membrane

9541:DERL3
gene id: 9541:DERL3
uniprot id: A0A2K5U6I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9541:REEP2
gene id: 9541:REEP2
uniprot id: A0A2K5W174
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CAMSAP2
gene id: 9541:CAMSAP2
uniprot id: A0A2K5WVP2
uniprot id: A0A2K5WVP7
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9541:DIPK2B
gene id: 9541:DIPK2B
uniprot id: A0A2K5VAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9541:LOC102144965
gene id: 9541:LOC102144965
uniprot id: A0A2K5ULV2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:HGF
gene id: 9541:HGF
uniprot id: C9E9X6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9541:B4GALT5
gene id: 9541:B4GALT5
uniprot id: A0A2K5U705
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:GDPGP1
gene id: 9541:GDPGP1
uniprot id: A0A2K5UIS4
uniprot id: Q8HXE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
messages: The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

9541:SBNO1
gene id: 9541:SBNO1
uniprot id: A0A2K5UZM4
uniprot id: A0A2K5UZV1
names: Similarity
messages: Belongs to the SBNO family.

9541:LOC102137557
gene id: 9541:LOC102137557
uniprot id: A0A2K5TSB9
names: Similarity
messages: Belongs to the PRAME family.

9541:TEAD1
gene id: 9541:TEAD1
uniprot id: G7PQP6
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102115783
gene id: 9541:LOC102115783
uniprot id: A0A2K5ULC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PROC
gene id: 9541:PROC
uniprot id: A0A2K5VQK4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:STK32A
gene id: 9541:STK32A
uniprot id: A0A2K5UD14
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:PRR15
gene id: 9541:PRR15
uniprot id: A0A8J8YSC4
uniprot id: G7P0H8
names: Similarity
messages: Belongs to the PRR15 family.

9541:POU6F1
gene id: 9541:POU6F1
uniprot id: A0A2K5VLS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9541:ERI1
gene id: 9541:ERI1
uniprot id: A0A2K5V361
names: Subcellular Location Annotation
messages: Cytoplasm

9541:LOC101866922
gene id: 9541:LOC101866922
uniprot id: A0A2K5UU22
uniprot id: A0A2K5UU73
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9541:SLF2
gene id: 9541:SLF2
uniprot id: A0A2K5W0G2
uniprot id: G7PDS0
names: Similarity
messages: Belongs to the FAM178 family.

9541:LOC101926836
gene id: 9541:LOC101926836
uniprot id: I7G9T7
names: Similarity
messages: Belongs to the NKAP family.

9541:NDUFA4
gene id: 9541:NDUFA4
uniprot id: Q4R542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex IV NDUFA4 subunit family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
messages: Mitochondrion inner membrane

9541:ITGA3
gene id: 9541:ITGA3
uniprot id: A0A2K5VFM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:LOC101925149
gene id: 9541:LOC101925149
uniprot id: A0A7N9D0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9541:DYRK3
gene id: 9541:DYRK3
uniprot id: A0A2K5WUQ4
uniprot id: A0A2K5WUR5
uniprot id: Q4R6S5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis.
messages: Interacts with SIRT1.
messages: Nucleus
messages: Nucleus speckle
messages: Protein kinase activity is activated following autophosphorylation at Tyr-349.
messages: Protein kinase activity is activated following autophosphorylation at Tyr-349. Autophosphorylation at Ser-330 stabilizes the protein and enhances the protein kinase activity.
messages: The N-terminal domain, which is intrinsically disordered, is required for stress granule localization.
messages: Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome.
messages: centrosome

9541:DHTKD1
gene id: 9541:DHTKD1
uniprot id: A0A2K5V4J4
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9541:DPCD
gene id: 9541:DPCD
uniprot id: A0A2K5TMH4
uniprot id: G7PDT2
uniprot id: I7GJI1
names: Similarity
messages: Belongs to the DPCD family.

9541:PLPP3
gene id: 9541:PLPP3
uniprot id: A0A2K5UKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:CRYZ
gene id: 9541:CRYZ
uniprot id: A0A2K5UDS8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9541:MDH1
gene id: 9541:MDH1
uniprot id: I7GHA1
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9541:PCMT1
gene id: 9541:PCMT1
uniprot id: A0A2K5TK85
uniprot id: I7G7X4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9541:FAM171B
gene id: 9541:FAM171B
uniprot id: A0A2K5VT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9541:LIPK
gene id: 9541:LIPK
uniprot id: A0A2K5VP87
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:DDIT3
gene id: 9541:DDIT3
uniprot id: A0A2K5VSM5
uniprot id: G7PIV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9541:PPM1N
gene id: 9541:PPM1N
uniprot id: A0A2K5TLZ4
names: Similarity
messages: Belongs to the PP2C family.

9541:HOXA1
gene id: 9541:HOXA1
uniprot id: A0A8J8Y696
uniprot id: G7P0P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9541:TAFAZZIN
gene id: 9541:TAFAZZIN
uniprot id: A0A2K5UMH0
uniprot id: A0A2K5UMJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9541:ABCC1
gene id: 9541:ABCC1
uniprot id: Q864R9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.
messages: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12657726). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

9541:CSTF3
gene id: 9541:CSTF3
uniprot id: A0A2K5UN07
names: Subcellular Location Annotation
messages: Nucleus

9541:ELP5
gene id: 9541:ELP5
uniprot id: Q4R2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9541:PLK1
gene id: 9541:PLK1
uniprot id: Q4R7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9541:DENND6B
gene id: 9541:DENND6B
uniprot id: A0A2K5X5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9541:CCL19
gene id: 9541:CCL19
uniprot id: C0ISS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:KCNK2
gene id: 9541:KCNK2
uniprot id: A0A2K5TJU3
uniprot id: A0A2K5TJU7
uniprot id: A0A8J8YP25
uniprot id: G7NTZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:ATP6V1H
gene id: 9541:ATP6V1H
uniprot id: A0A2K5V7B1
uniprot id: A0A8J8Y9P5
uniprot id: G7PBU4
uniprot id: I7G9L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:TPRG1L
gene id: 9541:TPRG1L
uniprot id: A0A2K5W509
names: Similarity
messages: Belongs to the TPRG1 family.

9541:LOC102146402
gene id: 9541:LOC102146402
uniprot id: Q4R3R2
names: Subcellular Location Annotation
messages: acrosome

9541:TFDP2
gene id: 9541:TFDP2
uniprot id: A0A2K5WZQ7
uniprot id: A0A2K5WZQ9
uniprot id: A0A2K5WZR4
uniprot id: A0A2K5WZS3
uniprot id: A0A2K5WZZ0
uniprot id: A0A7N9CWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:BNIP1
gene id: 9541:BNIP1
uniprot id: A0A2K5W4J6
names: Subcellular Location Annotation
messages: Membrane

9541:FAM163A
gene id: 9541:FAM163A
uniprot id: A0A8J8YA09
uniprot id: G7NU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9541:CWC15
gene id: 9541:CWC15
uniprot id: A0A2K5VJY0
names: Similarity
messages: Belongs to the CWC15 family.

9541:CYP46A1
gene id: 9541:CYP46A1
uniprot id: A0A2K5WEE0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:RTBDN
gene id: 9541:RTBDN
uniprot id: A0A2K5TT28
uniprot id: A0A7N9IFF7
names: Similarity
messages: Belongs to the folate receptor family.

9541:RDH11
gene id: 9541:RDH11
uniprot id: G8F2I0
uniprot id: Q4JK72
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:GGPS1
gene id: 9541:GGPS1
uniprot id: A0A8J8XIY0
uniprot id: G7NXI9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:IDH3B
gene id: 9541:IDH3B
uniprot id: A0A2K5UTS1
uniprot id: G7PGT6
uniprot id: Q28479
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion
messages: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
messages: The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.

9541:LOC102127506
gene id: 9541:LOC102127506
uniprot id: A0A8J8XD68
uniprot id: G7Q1V3
names: Similarity
messages: Belongs to the SPAN-X family.

9541:ASCC3
gene id: 9541:ASCC3
uniprot id: A0A2K5TXP5
names: Similarity
messages: Belongs to the helicase family.

9541:MAEL
gene id: 9541:MAEL
uniprot id: G7NU39
uniprot id: Q4R786
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the maelstrom family.
messages: Cytoplasm
messages: Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity). Interacts with TEX19 (By similarity).
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9541:WNK1
gene id: 9541:WNK1
uniprot id: A0A2K5WRV3
uniprot id: A0A2K5WS87
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9541:UBE4A
gene id: 9541:UBE4A
uniprot id: A0A2K5VY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9541:EIF2AK3
gene id: 9541:EIF2AK3
uniprot id: A0A2K5UXF2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:IMPDH1
gene id: 9541:IMPDH1
uniprot id: A0A2K5U6W4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9541:SYS1
gene id: 9541:SYS1
uniprot id: A0A2K5WIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9541:SLC25A46
gene id: 9541:SLC25A46
uniprot id: A0A2K5WSG9
uniprot id: Q4R3T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:TOMT
gene id: 9541:TOMT
uniprot id: A0A2K5WTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Endoplasmic reticulum

9541:CT83
gene id: 9541:CT83
uniprot id: Q4R717
names: Subcellular Location Annotation
messages: Cell membrane

9541:PSMB2
gene id: 9541:PSMB2
uniprot id: A0A7N9DA15
uniprot id: A0A8J8XJ00
uniprot id: G7NTH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:STXBP3
gene id: 9541:STXBP3
uniprot id: A0A2K5X901
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:CHMP2A
gene id: 9541:CHMP2A
uniprot id: A0A8J8XJE1
uniprot id: G7PZC8
names: Similarity
messages: Belongs to the SNF7 family.

9541:ZNF592
gene id: 9541:ZNF592
uniprot id: A0A2K5WEP3
uniprot id: G7P9C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:ETS1
gene id: 9541:ETS1
uniprot id: A0A2K5TYL4
uniprot id: A0A2K5TYT0
uniprot id: A0A7N9CV09
uniprot id: A0A8J8YQS4
uniprot id: G7PPN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor.

9541:RPL36AL
gene id: 9541:RPL36AL
uniprot id: A0A2K5TP61
uniprot id: G7Q2K4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:CTBS
gene id: 9541:CTBS
uniprot id: Q4R8U5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

9541:NEU4
gene id: 9541:NEU4
uniprot id: A0A7N9D9N0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9541:LOC102141127
gene id: 9541:LOC102141127
uniprot id: Q8MI29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.
messages: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).

9541:ACVR2A
gene id: 9541:ACVR2A
uniprot id: A0A7N9IF81
uniprot id: A0A8J8XY46
uniprot id: G7PKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:SMIM24
gene id: 9541:SMIM24
uniprot id: A0A2K5U1N4
names: Subcellular Location Annotation
messages: Membrane

9541:DHCR24
gene id: 9541:DHCR24
uniprot id: Q60HC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with DHCR7; this interaction regulates DHCR7 activity.

9541:ARF4
gene id: 9541:ARF4
uniprot id: A0A2K5UAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9541:VPS28
gene id: 9541:VPS28
uniprot id: A0A2K5TKI0
uniprot id: A0A7N9CK83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Endosome membrane
messages: Membrane

9541:PKD2L2
gene id: 9541:PKD2L2
uniprot id: Q4R933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9541:GRIN2A
gene id: 9541:GRIN2A
uniprot id: A0A2K5W5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:STX11
gene id: 9541:STX11
uniprot id: A0A8J8YD53
uniprot id: G7P509
names: Similarity
messages: Belongs to the syntaxin family.

9541:LHX3
gene id: 9541:LHX3
uniprot id: A0A2K5X0E1
uniprot id: A0A2K5X0F0
names: Subcellular Location Annotation
messages: Nucleus

9541:IRAK4
gene id: 9541:IRAK4
uniprot id: A0A2K5V3Y9
uniprot id: A0A2K5V433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9541:GSS
gene id: 9541:GSS
uniprot id: A0A8J8XKD1
uniprot id: G7PGJ4
uniprot id: I7GA31
uniprot id: Q8HXX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.
messages: Homodimer.

9541:SEMA3B
gene id: 9541:SEMA3B
uniprot id: A0A2K5VF98
uniprot id: G7NXT1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SNAP25
gene id: 9541:SNAP25
uniprot id: A0A2K5TV63
uniprot id: A0A7N9CTS0
uniprot id: A0A8J8YHL9
uniprot id: G7PGZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9541:TIGD6
gene id: 9541:TIGD6
uniprot id: A0A2K5ULI2
uniprot id: G7P8N9
names: Subcellular Location Annotation
messages: Nucleus

9541:ENTPD1
gene id: 9541:ENTPD1
uniprot id: A0A2K5WKL8
uniprot id: A0A7N9DGH8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:PSPC1
gene id: 9541:PSPC1
uniprot id: A0A2K5V444
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:PFN4
gene id: 9541:PFN4
uniprot id: A0A8J8XVF5
uniprot id: G7PLR1
names: Similarity
messages: Belongs to the profilin family.

9541:ACVR1B
gene id: 9541:ACVR1B
uniprot id: A0A2K5UYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:PRICKLE1
gene id: 9541:PRICKLE1
uniprot id: A0A2K5UIZ2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9541:MANBA
gene id: 9541:MANBA
uniprot id: A0A2K5U686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9541:LOC102135688
gene id: 9541:LOC102135688
uniprot id: A0A2K5UM27
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9541:RANGRF
gene id: 9541:RANGRF
uniprot id: A0A2K5VH47
uniprot id: A0A2K5VHA4
names: Similarity
messages: Belongs to the MOG1 family.

9541:NDC80
gene id: 9541:NDC80
uniprot id: Q4R630
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-53 and Lys-59 by KAT5 during mitosis, promoting robust kinetochore-microtubule attachment. Deacetylated by SIRT1.
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis. Interacts with CKAP5 (By similarity). Interacts with CDT1; leading to kinetochore localization of CDT1 (By similarity).
messages: Nucleus
messages: Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. Also phosphorylated by AURKA and AURKB.
messages: kinetochore

9541:PXN
gene id: 9541:PXN
uniprot id: A0A2K5UWD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9541:JRKL
gene id: 9541:JRKL
uniprot id: A0A8J8XV97
uniprot id: G7PNI8
names: Subcellular Location Annotation
messages: Nucleus

9541:VPS16
gene id: 9541:VPS16
uniprot id: A0A2K5TRK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9541:NUP107
gene id: 9541:NUP107
uniprot id: A0A2K5V237
uniprot id: A0A2K5V297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9541:IMPG2
gene id: 9541:IMPG2
uniprot id: A0A2K5V0I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9541:NIPA2
gene id: 9541:NIPA2
uniprot id: A0A2K5U1N2
uniprot id: A0A8J8XR58
uniprot id: G7PAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9541:CHRDL2
gene id: 9541:CHRDL2
uniprot id: A0A2K5VXR9
names: Subcellular Location Annotation
messages: Secreted

9541:LOC102122521
gene id: 9541:LOC102122521
uniprot id: A0A8J8Y2C7
uniprot id: G7PWD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9541:SPEN
gene id: 9541:SPEN
uniprot id: A0A2K5VXA6
names: Similarity
messages: Belongs to the RRM Spen family.

9541:SEPTIN3
gene id: 9541:SEPTIN3
uniprot id: A0A2K5X3R5
uniprot id: G7PFP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:FAM118A
gene id: 9541:FAM118A
uniprot id: A0A2K5V3F1
uniprot id: A0A7N9CQ53
uniprot id: G7PFX9
names: Similarity
messages: Belongs to the FAM118 family.

9541:GPR179
gene id: 9541:GPR179
uniprot id: A0A2K5W5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9541:CASKIN2
gene id: 9541:CASKIN2
uniprot id: A0A2K5W4M8
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SLC29A2
gene id: 9541:SLC29A2
uniprot id: A0A2K5X3A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9541:PRDX2
gene id: 9541:PRDX2
uniprot id: I7G9L9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9541:LOC102141103
gene id: 9541:LOC102141103
uniprot id: A0A2K5WH18
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:TLR1
gene id: 9541:TLR1
uniprot id: A0A2K5UN04
uniprot id: B3Y610
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9541:LBR
gene id: 9541:LBR
uniprot id: A0A2K5TKM6
uniprot id: A0A8J8XAI0
uniprot id: G7NTV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9541:CEP162
gene id: 9541:CEP162
uniprot id: A0A2K5UW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9541:SMARCAL1
gene id: 9541:SMARCAL1
uniprot id: A0A2K5WFT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9541:ABI3
gene id: 9541:ABI3
uniprot id: A0A2K5V191
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9541:TMEM200B
gene id: 9541:TMEM200B
uniprot id: A0A2K5WNS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9541:SFT2D1
gene id: 9541:SFT2D1
uniprot id: A0A8J8XND2
uniprot id: G7P487
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9541:CDK11B
gene id: 9541:CDK11B
uniprot id: A0A2K5VNP7
uniprot id: A0A2K5VNV4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9541:LOC102129802
gene id: 9541:LOC102129802
uniprot id: A0A2K5WAD7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9541:POLR2I
gene id: 9541:POLR2I
uniprot id: A0A8J8XYY8
uniprot id: G7PXC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9541:CNOT10
gene id: 9541:CNOT10
uniprot id: A0A2K5WWX6
uniprot id: A0A2K5WX48
uniprot id: A0A8J8XNM0
uniprot id: G7NYB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9541:BEX2
gene id: 9541:BEX2
uniprot id: A0A2K5X340
uniprot id: G7Q3C0
names: Similarity
messages: Belongs to the BEX family.

9541:IL11
gene id: 9541:IL11
uniprot id: P20808
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
messages: Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex.
messages: Secreted

9541:TRIM10
gene id: 9541:TRIM10
uniprot id: A0A2K5TSQ5
uniprot id: A0A2K5TSS0
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9541:TSPAN19
gene id: 9541:TSPAN19
uniprot id: A0A2K5WP42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:DPEP2
gene id: 9541:DPEP2
uniprot id: A0A2K5X8R4
names: Subcellular Location Annotation
messages: Membrane

9541:BCAN
gene id: 9541:BCAN
uniprot id: A0A2K5UB17
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:TEAD2
gene id: 9541:TEAD2
uniprot id: A0A2K5V9V8
uniprot id: A0A2K5V9X5
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102133844
gene id: 9541:LOC102133844
uniprot id: A0A2K5UGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CIAO1
gene id: 9541:CIAO1
uniprot id: A0A2K5UXP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9541:ZKSCAN1
gene id: 9541:ZKSCAN1
uniprot id: A0A7N9CR92
names: Subcellular Location Annotation
messages: Nucleus

9541:IWS1
gene id: 9541:IWS1
uniprot id: A0A2K5UHB8
names: Subcellular Location Annotation
messages: Nucleus

9541:TRAFD1
gene id: 9541:TRAFD1
uniprot id: Q4R970
names: Function
names: Subunit
messages: Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 and TRAF6.
messages: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).

9541:FMO5
gene id: 9541:FMO5
uniprot id: A0A2K5WER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:FAM114A1
gene id: 9541:FAM114A1
uniprot id: A0A2K5TU56
names: Similarity
messages: Belongs to the FAM114 family.

9541:WNT8B
gene id: 9541:WNT8B
uniprot id: A0A2K5V9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:WASF3
gene id: 9541:WASF3
uniprot id: A0A2K5UD70
uniprot id: A0A8J8YIG2
uniprot id: G7PVW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:NBL1
gene id: 9541:NBL1
uniprot id: A0A2K5WIY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9541:HSPA1A
gene id: 9541:HSPA1A
uniprot id: G8F3W4
uniprot id: I7GHC1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:MRPL30
gene id: 9541:MRPL30
uniprot id: A0A2K5TVD7
uniprot id: Q4R6U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9541:ALOX12
gene id: 9541:ALOX12
uniprot id: A0A2K5X446
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CMPK1
gene id: 9541:CMPK1
uniprot id: A0A2K5VB30
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9541:PIWIL1
gene id: 9541:PIWIL1
uniprot id: A0A2K5W1I1
uniprot id: A0A2K5W1Q3
uniprot id: A0A7N9CKW3
uniprot id: G8F4S6
names: Similarity
messages: Belongs to the argonaute family.

9541:PARP14
gene id: 9541:PARP14
uniprot id: A0A2K5WKP7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:MPV17L
gene id: 9541:MPV17L
uniprot id: A0A2K5WL30
uniprot id: A0A2K5WL49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9541:LYPD6B
gene id: 9541:LYPD6B
uniprot id: Q95JN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:WASF2
gene id: 9541:WASF2
uniprot id: A0A2K5U8K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:LOC102118091
gene id: 9541:LOC102118091
uniprot id: A0A2K5UJK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:STYXL2
gene id: 9541:STYXL2
uniprot id: A0A2K5UCP1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:GFOD2
gene id: 9541:GFOD2
uniprot id: A0A2K5WQL2
uniprot id: G7Q1E5
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9541:KRT84
gene id: 9541:KRT84
uniprot id: A0A2K5WH90
names: Similarity
messages: Belongs to the intermediate filament family.

9541:SCN11A
gene id: 9541:SCN11A
uniprot id: A0A2K5WUZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:CDK4
gene id: 9541:CDK4
uniprot id: I7GNS2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:PDE3A
gene id: 9541:PDE3A
uniprot id: A0A2K5VAH0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:TMEM63C
gene id: 9541:TMEM63C
uniprot id: A0A2K5WA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9541:ATG16L1
gene id: 9541:ATG16L1
uniprot id: A0A2K5TQA7
uniprot id: A0A2K5TQB6
uniprot id: A0A2K5TQC2
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9541:TRIM50
gene id: 9541:TRIM50
uniprot id: A0A2K5UQX6
uniprot id: A0A8J8Y414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9541:POMGNT1
gene id: 9541:POMGNT1
uniprot id: A0A2K5TKR7
uniprot id: A0A2K5TKS6
uniprot id: A0A2K5TKS7
uniprot id: A0A7N9CN01
uniprot id: G7NV04
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The cofactor is mostly bound to the substrate.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9541:GALNTL5
gene id: 9541:GALNTL5
uniprot id: A0A2K5VQ06
uniprot id: Q95JX4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Expressed in testis.
messages: In contrast to other members of the family, lacks the C-terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. The precise function of the enzyme is therefore unsure.
messages: Late endosome membrane
messages: Membrane
messages: Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region (By similarity).
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

9541:TPR
gene id: 9541:TPR
uniprot id: A0A2K5V4Q4
names: Similarity
messages: Belongs to the TPR family.

9541:EGF
gene id: 9541:EGF
uniprot id: A0A2K5WBP9
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PSMB3
gene id: 9541:PSMB3
uniprot id: A0A8J8XRQ2
uniprot id: G7PUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:TUBA3E
gene id: 9541:TUBA3E
uniprot id: Q4R4C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9541:CLTA
gene id: 9541:CLTA
uniprot id: A0A2K5VSX1
uniprot id: A0A2K5VSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9541:SNX14
gene id: 9541:SNX14
uniprot id: A0A2K5UFT4
uniprot id: A0A2K5UFU6
uniprot id: A0A2K5UFY4
names: Similarity
messages: Belongs to the sorting nexin family.

9541:CHRND
gene id: 9541:CHRND
uniprot id: A0A2K5V3B3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:EEF1A2
gene id: 9541:EEF1A2
uniprot id: A0A2K5VW69
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9541:GRIA2
gene id: 9541:GRIA2
uniprot id: A0A2K5TLX4
uniprot id: A0A2K5TLY7
uniprot id: Q38PU7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PRKCABP and GRIP2 (By similarity). Interacts with PICK1 (via PDZ domain) (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1 (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with OLFM2 (By similarity). Interacts with AP4B1, AP4E1 and AP4M1; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity). Forms a complex with NSG1, GRIP1 and STX12; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Interacts with IQSEC1; the interaction is required for ARF6 activation (By similarity).
messages: Membrane
messages: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
messages: Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation.
messages: Postsynaptic cell membrane
messages: Postsynaptic density membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
messages: Synaptic cell membrane
messages: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
messages: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate (By similarity).
messages: Ubiquitinated by RNF167, leading to its degradation.

9541:ARG1
gene id: 9541:ARG1
uniprot id: A0A2K5VUD1
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9541:GPRC5A
gene id: 9541:GPRC5A
uniprot id: A0A2K5V8R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:FICD
gene id: 9541:FICD
uniprot id: A0A8J8Y0R5
uniprot id: G7PI52
names: Similarity
messages: Belongs to the fic family.

9541:HYOU1
gene id: 9541:HYOU1
uniprot id: A0A2K5TVL3
uniprot id: G7PP46
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:CLPTM1
gene id: 9541:CLPTM1
uniprot id: A0A2K5UPT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9541:NDUFB9
gene id: 9541:NDUFB9
uniprot id: A0A2K5W8B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:INHA
gene id: 9541:INHA
uniprot id: A0A2K5U0P0
uniprot id: G7PK56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9541:KRT39
gene id: 9541:KRT39
uniprot id: A0A2K5V6W8
names: Similarity
messages: Belongs to the intermediate filament family.

9541:HTR7
gene id: 9541:HTR7
uniprot id: A0A2K5U8R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CAMK2G
gene id: 9541:CAMK2G
uniprot id: A0A2K5UV06
uniprot id: A0A2K5UV14
uniprot id: A0A2K5UV18
uniprot id: A0A2K5UV98
uniprot id: A0A2K5UVA9
uniprot id: I7GJL2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:TXN
gene id: 9541:TXN
uniprot id: A0A7N9CH45
names: Similarity
messages: Belongs to the thioredoxin family.

9541:DPEP3
gene id: 9541:DPEP3
uniprot id: Q4R7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).
messages: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (By similarity). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (By similarity). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (By similarity).
messages: Membrane

9541:NAMPT
gene id: 9541:NAMPT
uniprot id: A0A2K5ULM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9541:ITGB3
gene id: 9541:ITGB3
uniprot id: A0A2K5WYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9541:NAB1
gene id: 9541:NAB1
uniprot id: A0A2K5U7H0
uniprot id: A0A2K5U7I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9541:BAX
gene id: 9541:BAX
uniprot id: A0A2K5V7Y8
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:CMKLR1
gene id: 9541:CMKLR1
uniprot id: A0A2K5UG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9541:MYLK
gene id: 9541:MYLK
uniprot id: A0A2K5TQ52
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9541:GNRHR
gene id: 9541:GNRHR
uniprot id: A0A2K5WH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GIPC1
gene id: 9541:GIPC1
uniprot id: A0A2K5W0Z3
uniprot id: G7PZL8
names: Similarity
messages: Belongs to the GIPC family.

9541:VTI1B
gene id: 9541:VTI1B
uniprot id: I7GDL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9541:MITF
gene id: 9541:MITF
uniprot id: A0A2K5WMF9
uniprot id: G7NZ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:CD68
gene id: 9541:CD68
uniprot id: A0A8J8XNB1
uniprot id: G7PTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9541:GPR156
gene id: 9541:GPR156
uniprot id: A0A2K5X7P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:DEFB125
gene id: 9541:DEFB125
uniprot id: A4H241
uniprot id: G7PGQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:HDHD2
gene id: 9541:HDHD2
uniprot id: A0A2K5UFD7
uniprot id: A0A7N9IF34
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9541:MERTK
gene id: 9541:MERTK
uniprot id: A0A2K5V1H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9541:RALB
gene id: 9541:RALB
uniprot id: Q4R379
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with EXOC2/Sec5 and EXOC8/Exo84. Interacts (via effector domain) with RALBP1.
messages: Midbody
messages: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
messages: Prenylation is essential for membrane localization.
messages: The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors.

9541:EYA3
gene id: 9541:EYA3
uniprot id: A0A2K5VT84
uniprot id: A0A2K5VTC8
uniprot id: A0A2K5VTE3
uniprot id: A0A8J8YLN9
uniprot id: G7NWV3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9541:LTBR
gene id: 9541:LTBR
uniprot id: A0A2K5VGQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ADAMTS19
gene id: 9541:ADAMTS19
uniprot id: A0A2K5VGR3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RSPO2
gene id: 9541:RSPO2
uniprot id: A0A8J8Y480
uniprot id: G7PCH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9541:LOC102140817
gene id: 9541:LOC102140817
uniprot id: A0A2K5ULX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:EOMES
gene id: 9541:EOMES
uniprot id: A0A2K5TX18
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:CUL3
gene id: 9541:CUL3
uniprot id: A0A2K5W2Z2
uniprot id: A0A2K5W2Z9
uniprot id: G7PK72
names: Similarity
messages: Belongs to the cullin family.

9541:DESI1
gene id: 9541:DESI1
uniprot id: A0A2K5WHF5
uniprot id: A0A7N9D5H3
names: Similarity
messages: Belongs to the DeSI family.

9541:SKAP2
gene id: 9541:SKAP2
uniprot id: A0A2K5X5C8
uniprot id: G7P0P4
names: Similarity
messages: Belongs to the SKAP family.

9541:KCNIP4
gene id: 9541:KCNIP4
uniprot id: Q8HYN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the recoverin family.
messages: Cell membrane
messages: Component of heteromultimeric potassium channels (By similarity). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 (By similarity). Interacts with KCND3 (By similarity). Interacts with the C-terminus of PSEN2 and probably PSEN1 (By similarity).
messages: Cytoplasm
messages: Peroxisome
messages: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
messages: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current.

9541:EIF4E1B
gene id: 9541:EIF4E1B
uniprot id: A0A2K5UXH0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9541:GPD1L
gene id: 9541:GPD1L
uniprot id: A0A2K5V4P5
uniprot id: A0A8J8XJW7
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9541:LOC102136643
gene id: 9541:LOC102136643
uniprot id: A0A2K5UHW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ASXL1
gene id: 9541:ASXL1
uniprot id: A0A2K5UMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9541:G6PC1
gene id: 9541:G6PC1
uniprot id: A0A7N9IAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9541:MKX
gene id: 9541:MKX
uniprot id: A0A7N9IFI3
names: Subcellular Location Annotation
messages: Nucleus

9541:SMO
gene id: 9541:SMO
uniprot id: A0A2K5VTF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ATP10D
gene id: 9541:ATP10D
uniprot id: A0A2K5V4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9541:BRMS1L
gene id: 9541:BRMS1L
uniprot id: A0A2K5WK40
names: Subcellular Location Annotation
messages: Nucleus

9541:HDAC4
gene id: 9541:HDAC4
uniprot id: A0A2K5V841
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9541:UBA1
gene id: 9541:UBA1
uniprot id: A0A2K5U8P9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9541:LOC102123657
gene id: 9541:LOC102123657
uniprot id: A0A2K5VQB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:DPPA5
gene id: 9541:DPPA5
uniprot id: A0A8J8YQ00
uniprot id: G7P3F8
names: Similarity
messages: Belongs to the KHDC1 family.

9541:LOC102140281
gene id: 9541:LOC102140281
uniprot id: A0A2K5UVK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9541:TGFBI
gene id: 9541:TGFBI
uniprot id: A0A2K5X4B3
uniprot id: A0A7N9CID1
names: Subcellular Location Annotation
messages: extracellular matrix

9541:ANHX
gene id: 9541:ANHX
uniprot id: A0A7N9CDR5
names: Subcellular Location Annotation
messages: Nucleus

9541:ABHD2
gene id: 9541:ABHD2
uniprot id: G7P9E4
uniprot id: Q4R2Y9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acylglycerol lipase activity is activated upon binding to progesterone.
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
messages: Cell membrane
messages: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity).

9541:BACE1
gene id: 9541:BACE1
uniprot id: A0A2K5UWX5
uniprot id: A0A8J8YG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: Secreted
messages: trans-Golgi network

9541:LOC102139510
gene id: 9541:LOC102139510
uniprot id: A0A158SIQ0
uniprot id: Q8SPI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:CALHM5
gene id: 9541:CALHM5
uniprot id: A0A7N9CK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:UTS2R
gene id: 9541:UTS2R
uniprot id: A0A2K5UGD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

9541:NDUFS5
gene id: 9541:NDUFS5
uniprot id: Q4R3M6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:PLCZ1
gene id: 9541:PLCZ1
uniprot id: A0A2K5U976
uniprot id: Q95JS1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
messages: Nucleus
messages: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
messages: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9541:MMP7
gene id: 9541:MMP7
uniprot id: A0A8J8XW62
uniprot id: G7PNJ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9541:TAPT1
gene id: 9541:TAPT1
uniprot id: A0A2K5U6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9541:GTDC1
gene id: 9541:GTDC1
uniprot id: A0A2K5V379
uniprot id: A0A2K5V381
uniprot id: A0A7N9CGC9
uniprot id: G7PKJ2
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9541:SSBP3
gene id: 9541:SSBP3
uniprot id: A0A2K5UU13
uniprot id: A0A2K5UU19
uniprot id: A0A7N9CAU5
uniprot id: A0A7N9CM22
names: Subcellular Location Annotation
messages: Nucleus

9541:EXOC1
gene id: 9541:EXOC1
uniprot id: A0A2K5WZS8
uniprot id: A0A2K5WZT6
uniprot id: A0A2K5X0E3
uniprot id: A0A7N9CER2
names: Similarity
messages: Belongs to the SEC3 family.

9541:GMPR2
gene id: 9541:GMPR2
uniprot id: A0A2K5USU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9541:CXCL13
gene id: 9541:CXCL13
uniprot id: H6WS58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:SH3GL3
gene id: 9541:SH3GL3
uniprot id: A0A2K5WLY9
uniprot id: I7G2Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9541:SMAD1
gene id: 9541:SMAD1
uniprot id: A0A2K5WIT6
uniprot id: G7P6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9541:ELP6
gene id: 9541:ELP6
uniprot id: A0A2K5X1A6
names: Similarity
messages: Belongs to the ELP6 family.

9541:ST3GAL6
gene id: 9541:ST3GAL6
uniprot id: A0A2K5WZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:CCN4
gene id: 9541:CCN4
uniprot id: A0A8J8XJS4
uniprot id: G7PD02
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:TUSC3
gene id: 9541:TUSC3
uniprot id: A0A2K5X4U9
uniprot id: I7GHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:DSTN
gene id: 9541:DSTN
uniprot id: A0A2K5U939
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9541:LMNTD1
gene id: 9541:LMNTD1
uniprot id: Q4R899
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102137176
gene id: 9541:LOC102137176
uniprot id: A0A2K5VP36
names: Similarity
messages: Belongs to the multicopper oxidase family.

9541:ORC4
gene id: 9541:ORC4
uniprot id: A0A7N9CQ05
uniprot id: A0A8J8XCG5
uniprot id: G7PKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9541:PFDN5
gene id: 9541:PFDN5
uniprot id: G7PHU6
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9541:LXN
gene id: 9541:LXN
uniprot id: A0A2K5WLX9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9541:LOC102127018
gene id: 9541:LOC102127018
uniprot id: A0A8J8YF72
uniprot id: G7P653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:BCL2L14
gene id: 9541:BCL2L14
uniprot id: Q4R843
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:MPV17
gene id: 9541:MPV17
uniprot id: A0A2K5W873
uniprot id: G7PLV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9541:KRT71
gene id: 9541:KRT71
uniprot id: A0A2K5V945
names: Similarity
messages: Belongs to the intermediate filament family.

9541:HVCN1
gene id: 9541:HVCN1
uniprot id: A0A2K5VVC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9541:AMIGO2
gene id: 9541:AMIGO2
uniprot id: A0A8J8XCC5
uniprot id: G7PHN7
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9541:RBX1
gene id: 9541:RBX1
uniprot id: Q2PFW7
names: Similarity
messages: Belongs to the RING-box family.

9541:EPN2
gene id: 9541:EPN2
uniprot id: A0A2K5WRE9
uniprot id: A0A2K5WRF8
names: Similarity
messages: Belongs to the epsin family.

9541:DGKG
gene id: 9541:DGKG
uniprot id: A0A2K5VZE7
uniprot id: A0A2K5VZF7
uniprot id: A0A2K5VZG5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9541:NPEPPS
gene id: 9541:NPEPPS
uniprot id: A0A2K5WAU9
uniprot id: A0A2K5WAW0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9541:KIFC3
gene id: 9541:KIFC3
uniprot id: A0A2K5U3M7
uniprot id: A0A2K5U3N4
uniprot id: A0A2K5U3P8
uniprot id: A0A2K5U3Q0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:SPECC1L
gene id: 9541:SPECC1L
uniprot id: A0A2K5UZ70
uniprot id: A0A7N9IEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9541:GFM1
gene id: 9541:GFM1
uniprot id: A0A2K5VAV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9541:EIF3J
gene id: 9541:EIF3J
uniprot id: A0A2K5UTF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9541:S100A9
gene id: 9541:S100A9
uniprot id: A0A2K5VRV3
names: Similarity
messages: Belongs to the S-100 family.

9541:LZTFL1
gene id: 9541:LZTFL1
uniprot id: A0A2K5WC78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9541:MAN1A1
gene id: 9541:MAN1A1
uniprot id: A0A2K5WX40
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:NEK7
gene id: 9541:NEK7
uniprot id: A0A8J8YPW1
uniprot id: G7NWH7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:NLRP4
gene id: 9541:NLRP4
uniprot id: A0A2K5WDX6
names: Similarity
messages: Belongs to the NLRP family.

9541:PSME1
gene id: 9541:PSME1
uniprot id: P58238
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the PA28 family.
messages: By interferon gamma.
messages: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9541:NFASC
gene id: 9541:NFASC
uniprot id: A0A2K5VE22
uniprot id: A0A2K5VE36
uniprot id: A0A2K5VEA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9541:PLAT
gene id: 9541:PLAT
uniprot id: A0A2K5VX93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:B3GNT2
gene id: 9541:B3GNT2
uniprot id: A0A8J8YEF2
uniprot id: G7PMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:SLC16A11
gene id: 9541:SLC16A11
uniprot id: A0A2K5VRP5
names: Subcellular Location Annotation
messages: Membrane

9541:S100A11
gene id: 9541:S100A11
uniprot id: A0A7N9CR25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9541:PCNX3
gene id: 9541:PCNX3
uniprot id: A0A2K5VMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9541:GLUL
gene id: 9541:GLUL
uniprot id: A0A2K5TNL4
uniprot id: A0A7N9CVE9
uniprot id: Q4R7U3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Decamer; composed of two pentamers (By similarity). Interacts with PALMD (By similarity). Interacts with RHOJ (By similarity).
messages: Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO).
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).
messages: Membrane
messages: Microsome
messages: Mitochondrion
messages: Palmitoylated; undergoes autopalmitoylation.
messages: Ubiquitinated by ZNRF1.
messages: cytosol

9541:RNF40
gene id: 9541:RNF40
uniprot id: A0A2K5V529
uniprot id: G7Q0Y6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9541:NSG2
gene id: 9541:NSG2
uniprot id: Q4R4W7
names: Similarity
messages: Belongs to the NSG family.

9541:ELOVL7
gene id: 9541:ELOVL7
uniprot id: A0A2K5WJH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9541:LRRC8E
gene id: 9541:LRRC8E
uniprot id: A0A2K5WKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:MED12L
gene id: 9541:MED12L
uniprot id: A0A2K5VQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9541:SCP2
gene id: 9541:SCP2
uniprot id: A0A2K5WYJ1
uniprot id: G7NVP8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9541:PMVK
gene id: 9541:PMVK
uniprot id: A0A2K5V250
names: Subcellular Location Annotation
messages: cytosol

9541:CBY2
gene id: 9541:CBY2
uniprot id: Q95JK3
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1 (By similarity).

9541:MEF2D
gene id: 9541:MEF2D
uniprot id: A0A2K5US28
uniprot id: A0A2K5US42
uniprot id: A0A2K5USA9
names: Subcellular Location Annotation
messages: Nucleus

9541:KATNAL2
gene id: 9541:KATNAL2
uniprot id: A0A2K5UN63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9541:PLBD1
gene id: 9541:PLBD1
uniprot id: A0A2K5WJA1
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9541:LIF
gene id: 9541:LIF
uniprot id: A0A2K5UCA6
uniprot id: A0A2K5UCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9541:ZEB1
gene id: 9541:ZEB1
uniprot id: A0A2K5W193
uniprot id: A0A2K5W1B1
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9541:ATR
gene id: 9541:ATR
uniprot id: A0A2K5U8D7
uniprot id: A0A7N9D8L4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9541:CTC1
gene id: 9541:CTC1
uniprot id: A0A2K5U8A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9541:BFSP1
gene id: 9541:BFSP1
uniprot id: A0A2K5V910
uniprot id: A0A2K5V913
uniprot id: A0A2K5V926
uniprot id: Q4R307
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9541:LOC102134014
gene id: 9541:LOC102134014
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:SLC7A2
gene id: 9541:SLC7A2
uniprot id: A0A2K5URE1
uniprot id: A0A2K5URF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:CBLC
gene id: 9541:CBLC
uniprot id: A0A2K5V7D8
uniprot id: A0A2K5V7G2
uniprot id: G7PXV0
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9541:CHD6
gene id: 9541:CHD6
uniprot id: A0A2K5V6Y8
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9541:HEATR9
gene id: 9541:HEATR9
uniprot id: Q4R744
names: Caution
messages: Despite its name, the presence of HEAT repeat is unsure and is not confirmed by repeat-detection programs.

9541:CD55
gene id: 9541:CD55
uniprot id: A0A2K5X1U9
uniprot id: A0A2K5X1V4
uniprot id: A0A2K5X1Z0
uniprot id: A0A2K5X1Z6
uniprot id: A0A7N9CFZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GUCY1B1
gene id: 9541:GUCY1B1
uniprot id: A0A2K5VKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9541:TMSB10
gene id: 9541:TMSB10
uniprot id: A0A2K5VWM9
uniprot id: G7P4J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:SYCE1L
gene id: 9541:SYCE1L
uniprot id: A0A2K5UVY6
names: Similarity
messages: Belongs to the SYCE family.

9541:FXR2
gene id: 9541:FXR2
uniprot id: A0A2K5VES1
names: Similarity
messages: Belongs to the FMR1 family.

9541:PRPF19
gene id: 9541:PRPF19
uniprot id: A0A2K5W3D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9541:KIF11
gene id: 9541:KIF11
uniprot id: A0A2K5U289
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:NRP2
gene id: 9541:NRP2
uniprot id: A0A2K5X2N5
uniprot id: A0A2K5X335
uniprot id: G7PL91
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TIMM8A
gene id: 9541:TIMM8A
uniprot id: A0A2K5X878
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9541:ART3
gene id: 9541:ART3
uniprot id: A0A2K5TMJ0
uniprot id: Q9GKV6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9541:DSEL
gene id: 9541:DSEL
uniprot id: A0A2K5TP95
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9541:CBL
gene id: 9541:CBL
uniprot id: A0A2K5X0C9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9541:HSD17B12
gene id: 9541:HSD17B12
uniprot id: I7GJW2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:KIF9
gene id: 9541:KIF9
uniprot id: A0A2K5VJ68
uniprot id: A0A8J8YN76
uniprot id: G7NXW4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:ALAD
gene id: 9541:ALAD
uniprot id: Q4R4E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

9541:NRXN2
gene id: 9541:NRXN2
uniprot id: A0A2K5W6M0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EPGN
gene id: 9541:EPGN
uniprot id: A0A8J8YCK1
uniprot id: G7P5K4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MYH6
gene id: 9541:MYH6
uniprot id: A0A2K5X7N7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:SMIM15
gene id: 9541:SMIM15
uniprot id: A0A8J8XQD8
uniprot id: G7P7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9541:GRPEL2
gene id: 9541:GRPEL2
uniprot id: A0A2K5VN42
uniprot id: G7P8N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9541:CTLA4
gene id: 9541:CTLA4
uniprot id: A0A2K5W1Z9
uniprot id: G7PL88
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9541:PPP1CA
gene id: 9541:PPP1CA
uniprot id: A0A2K5TW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9541:CTH
gene id: 9541:CTH
uniprot id: G7NWZ5
uniprot id: Q60HG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity).
messages: Cytoplasm
messages: Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity).

9541:ACAA2
gene id: 9541:ACAA2
uniprot id: I7G666
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9541:LRRC8B
gene id: 9541:LRRC8B
uniprot id: A0A2K5UKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:SRPRA
gene id: 9541:SRPRA
uniprot id: A0A2K5V3D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9541:CAMKK2
gene id: 9541:CAMKK2
uniprot id: A0A7N9CZ65
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:VAMP4
gene id: 9541:VAMP4
uniprot id: A0A8J8XDD2
uniprot id: G7NVH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:RALY
gene id: 9541:RALY
uniprot id: A0A2K5V6P9
uniprot id: A0A2K5V6S2
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9541:RGS4
gene id: 9541:RGS4
uniprot id: A0A2K5U7U7
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9541:SS18
gene id: 9541:SS18
uniprot id: A0A2K5VBW7
uniprot id: A0A2K5VBX2
uniprot id: G7PWJ4
uniprot id: I7GN06
names: Similarity
messages: Belongs to the SS18 family.

9541:FAM20B
gene id: 9541:FAM20B
uniprot id: A0A7N9CV74
names: Similarity
messages: Belongs to the FAM20 family.

9541:PGLYRP3
gene id: 9541:PGLYRP3
uniprot id: A0A2K5TR02
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9541:DENR
gene id: 9541:DENR
uniprot id: A0A2K5TSX6
names: Similarity
messages: Belongs to the DENR family.

9541:SGSM1
gene id: 9541:SGSM1
uniprot id: A0A2K5UIZ4
uniprot id: A0A2K5UJ14
uniprot id: A0A2K5UJ30
uniprot id: A0A7N9C9P6
names: Similarity
messages: Belongs to the RUTBC family.

9541:ALLC
gene id: 9541:ALLC
uniprot id: G8F4Y6
uniprot id: Q4R964
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9541:FFAR2
gene id: 9541:FFAR2
uniprot id: A0A2K5UIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:VPS45
gene id: 9541:VPS45
uniprot id: G7NTS3
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:ILDR1
gene id: 9541:ILDR1
uniprot id: A0A2K5X4D8
uniprot id: A0A2K5X4I6
uniprot id: A0A8J8Y1N8
uniprot id: G7NXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9541:FGF1
gene id: 9541:FGF1
uniprot id: A0A2K5UVN5
uniprot id: A0A7N9ICC4
uniprot id: A0A8J8XW05
uniprot id: G7P8J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9541:LOC102146338
gene id: 9541:LOC102146338
uniprot id: A0A2K5VBJ9
uniprot id: G7NTV6
uniprot id: G8F324
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:PIK3CB
gene id: 9541:PIK3CB
uniprot id: A0A2K5U222
uniprot id: A0A8J8XJE7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:GCHFR
gene id: 9541:GCHFR
uniprot id: A0A8J8YET9
uniprot id: G7PAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9541:HADH
gene id: 9541:HADH
uniprot id: I7G921
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9541:RNF8
gene id: 9541:RNF8
uniprot id: I7G290
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9541:EMC3
gene id: 9541:EMC3
uniprot id: A0A2K5TWC4
uniprot id: G8F3B3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9541:GABRB2
gene id: 9541:GABRB2
uniprot id: A0A2K5X1S8
uniprot id: A0A8J8YKT6
uniprot id: G7P6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:ITPK1
gene id: 9541:ITPK1
uniprot id: A0A2K5TLX3
names: Similarity
messages: Belongs to the ITPK1 family.

9541:MTCP1
gene id: 9541:MTCP1
uniprot id: A0A2K5U7K1
names: Similarity
messages: Belongs to the TCL1 family.

9541:VEZT
gene id: 9541:VEZT
uniprot id: A0A2K5X2Y1
uniprot id: A0A7N9CKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9541:TMED2
gene id: 9541:TMED2
uniprot id: A0A2K5TLN0
uniprot id: Q4R5D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9541:GALNT12
gene id: 9541:GALNT12
uniprot id: A0A2K5WI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:TTC30B
gene id: 9541:TTC30B
uniprot id: A0A2K5UFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9541:AURKB
gene id: 9541:AURKB
uniprot id: A0A2K5WL61
uniprot id: G7PTK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9541:GOSR2
gene id: 9541:GOSR2
uniprot id: A0A2K5W8P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9541:RPL8
gene id: 9541:RPL8
uniprot id: I7GMX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9541:IGF2R
gene id: 9541:IGF2R
uniprot id: A0A2K5WFU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NR2C1
gene id: 9541:NR2C1
uniprot id: G8F430
uniprot id: Q95K90
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).
messages: PML body
messages: Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-220, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).
messages: Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).

9541:SLC35A4
gene id: 9541:SLC35A4
uniprot id: G7P8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9541:DCTN6
gene id: 9541:DCTN6
uniprot id: A0A2K5WV70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9541:BCL7B
gene id: 9541:BCL7B
uniprot id: A0A2K5WN28
names: Similarity
messages: Belongs to the BCL7 family.

9541:VAC14
gene id: 9541:VAC14
uniprot id: A0A2K5WZL7
uniprot id: G7Q1L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9541:LSM2
gene id: 9541:LSM2
uniprot id: A0A2K5U9H6
uniprot id: G8F3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9541:ZFX
gene id: 9541:ZFX
uniprot id: A0A2K5UW34
uniprot id: A0A2K5UW70
names: Subcellular Location Annotation
messages: Nucleus

9541:DRGX
gene id: 9541:DRGX
uniprot id: A0A2K5UVS1
names: Subcellular Location Annotation
messages: Nucleus

9541:PIGW
gene id: 9541:PIGW
uniprot id: A0A2K5UBR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9541:LAMA2
gene id: 9541:LAMA2
uniprot id: A0A2K5X4C3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9541:DTNA
gene id: 9541:DTNA
uniprot id: A0A2K5UWT3
uniprot id: A0A2K5UX96
uniprot id: A0A2K5UXA6
uniprot id: A0A2K5UXF6
uniprot id: A0A2K5UXG7
uniprot id: A0A2K5UXH1
uniprot id: A0A2K5UXK1
uniprot id: A0A2K5UXM2
uniprot id: A0A2K5UXS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9541:LRRFIP2
gene id: 9541:LRRFIP2
uniprot id: A0A2K5V262
uniprot id: A0A2K5V269
uniprot id: A0A2K5V285
uniprot id: A0A2K5V2B7
uniprot id: A0A8J8Y1V3
uniprot id: G7NYL4
names: Similarity
messages: Belongs to the LRRFIP family.

9541:HOXB5
gene id: 9541:HOXB5
uniprot id: Q2PFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:KATNB1
gene id: 9541:KATNB1
uniprot id: A0A2K5VFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9541:CLDND2
gene id: 9541:CLDND2
uniprot id: A0A2K5WXQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:KCNC2
gene id: 9541:KCNC2
uniprot id: A0A2K5V4K9
uniprot id: A0A2K5V4M9
uniprot id: A0A2K5V4P9
uniprot id: A0A2K5V4V6
uniprot id: A0A2K5V4W3
uniprot id: A0A7N9CRZ4
uniprot id: A0A7N9IBK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:MINDY1
gene id: 9541:MINDY1
uniprot id: Q4R7C0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9541:DUOX1
gene id: 9541:DUOX1
uniprot id: A0A2K5VI09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9541:ALDOC
gene id: 9541:ALDOC
uniprot id: A0A805Q5V7
uniprot id: G7PTX4
uniprot id: Q9GKW3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer. Interacts with ATP6V1E1.
messages: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

9541:LOC102145378
gene id: 9541:LOC102145378
uniprot id: A0A2K5UXA8
names: Similarity
messages: Belongs to the PROTOR family.

9541:SIGMAR1
gene id: 9541:SIGMAR1
uniprot id: A0A2K5VK98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9541:LOC102141219
gene id: 9541:LOC102141219
uniprot id: A0A2K5UIS1
uniprot id: G8F2Z1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:TSPAN4
gene id: 9541:TSPAN4
uniprot id: A0A2K5VRQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:CAPZB
gene id: 9541:CAPZB
uniprot id: A0A2K5TMG9
uniprot id: A0A2K5TMI1
uniprot id: A0A2K5TMI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

9541:TMEM45B
gene id: 9541:TMEM45B
uniprot id: A0A2K5W1T8
uniprot id: G7PPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9541:MLH1
gene id: 9541:MLH1
uniprot id: A0A2K5UB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9541:ALK
gene id: 9541:ALK
uniprot id: A0A2K5V4W8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

9541:PTGER4
gene id: 9541:PTGER4
uniprot id: Q4R6E1
uniprot id: Q95J39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9541:PLAC8L1
gene id: 9541:PLAC8L1
uniprot id: A0A8J8XRF4
uniprot id: G7P8K5
names: Similarity
messages: Belongs to the cornifelin family.

9541:NDUFB10
gene id: 9541:NDUFB10
uniprot id: A0A2K5X7S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9541:E2F8
gene id: 9541:E2F8
uniprot id: A0A2K5WTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:LOC102137734
gene id: 9541:LOC102137734
uniprot id: A0A2K5V565
uniprot id: A0A8J8YNK8
uniprot id: G7Q1B2
names: Subcellular Location Annotation
messages: Membrane

9541:PRKN
gene id: 9541:PRKN
uniprot id: B8YGJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9541:SLC19A2
gene id: 9541:SLC19A2
uniprot id: A0A2K5WZ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9541:PTPRG
gene id: 9541:PTPRG
uniprot id: A0A2K5VK93
uniprot id: A0A2K5VKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9541:RTN4
gene id: 9541:RTN4
uniprot id: A0A2K5W7M0
uniprot id: A0A2K5W7M8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LAMP3
gene id: 9541:LAMP3
uniprot id: A0A2K5W1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9541:LOC102119400
gene id: 9541:LOC102119400
uniprot id: A0A2K5X463
uniprot id: Q95LR9
names: Subcellular Location Annotation
messages: Secreted

9541:XYLB
gene id: 9541:XYLB
uniprot id: A0A2K5U7M5
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9541:ST3GAL3
gene id: 9541:ST3GAL3
uniprot id: A0A2K5WPF8
uniprot id: A0A2K5WPK4
uniprot id: A0A2K5WQ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:SLC11A2
gene id: 9541:SLC11A2
uniprot id: Q4R4D6
uniprot id: Q9MZV1
uniprot id: Q9MZV2
names: Similarity
messages: Belongs to the NRAMP family.

9541:UCP2
gene id: 9541:UCP2
uniprot id: A0A8J8YLM4
uniprot id: G7PN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LOC102133997
gene id: 9541:LOC102133997
uniprot id: A0A2K5VAT4
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MPP1
gene id: 9541:MPP1
uniprot id: A0A2K5WSK7
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9541:DLD
gene id: 9541:DLD
uniprot id: A0A2K5TZW4
uniprot id: G7P2G2
uniprot id: Q60HG3
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

9541:SPRTN
gene id: 9541:SPRTN
uniprot id: A0A2K5U0J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9541:AREL1
gene id: 9541:AREL1
uniprot id: A0A2K5U585
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CDKAL1
gene id: 9541:CDKAL1
uniprot id: A0A2K5V9T0
uniprot id: G7P4I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9541:RIC8A
gene id: 9541:RIC8A
uniprot id: A0A2K5V8L6
uniprot id: Q4R720
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).
messages: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9541:SEMA3F
gene id: 9541:SEMA3F
uniprot id: A0A2K5TXU6
uniprot id: A0A2K5TXU8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NAT14
gene id: 9541:NAT14
uniprot id: Q9N0D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the camello family.
messages: May act as a transcription factor regulating the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element.
messages: Membrane
messages: Probable acetyltransferase.

9541:LOC101867486
gene id: 9541:LOC101867486
uniprot id: A0A8J8YLZ9
uniprot id: G7P4F8
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9541:PLOD1
gene id: 9541:PLOD1
uniprot id: A0A2K5U252
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:NEMP1
gene id: 9541:NEMP1
uniprot id: A0A2K5TV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9541:FBXO46
gene id: 9541:FBXO46
uniprot id: A0A2K5V8U2
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9541:CA6
gene id: 9541:CA6
uniprot id: A0A2K5U933
uniprot id: A0A2K5U949
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

9541:STX7
gene id: 9541:STX7
uniprot id: I7G8H7
names: Similarity
messages: Belongs to the syntaxin family.

9541:HMX2
gene id: 9541:HMX2
uniprot id: A0A7N9CFD7
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102143828
gene id: 9541:LOC102143828
uniprot id: A0A2K5UG57
names: Similarity
messages: Belongs to the serpin family.

9541:MRPL47
gene id: 9541:MRPL47
uniprot id: A0A7N9DBX8
uniprot id: I7G764
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9541:OLFML2B
gene id: 9541:OLFML2B
uniprot id: A0A2K5U6C4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TLL2
gene id: 9541:TLL2
uniprot id: A0A2K5W5W3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DOCK2
gene id: 9541:DOCK2
uniprot id: A0A2K5X7U6
uniprot id: A0A2K5X895
names: Similarity
messages: Belongs to the DOCK family.

9541:ILDR2
gene id: 9541:ILDR2
uniprot id: A0A2K5U0S7
uniprot id: A0A2K5U0T8
uniprot id: A0A2K5U0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9541:SNRPD1
gene id: 9541:SNRPD1
uniprot id: Q4R5F6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9541:VGLL1
gene id: 9541:VGLL1
uniprot id: A0A2K5VB36
uniprot id: G7Q1T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9541:LOC102130015
gene id: 9541:LOC102130015
uniprot id: A0A2K5UFJ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9541:NCAN
gene id: 9541:NCAN
uniprot id: A0A2K5VGK7
names: Caution
names: Similarity
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:KRT34
gene id: 9541:KRT34
uniprot id: A0A2K5WLV1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:TGIF2
gene id: 9541:TGIF2
uniprot id: A0A2K5U881
names: Subcellular Location Annotation
messages: Nucleus

9541:PLAC1
gene id: 9541:PLAC1
uniprot id: G7Q1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9541:PRSS16
gene id: 9541:PRSS16
uniprot id: A0A2K5WDF6
names: Similarity
messages: Belongs to the peptidase S28 family.

9541:SNTG1
gene id: 9541:SNTG1
uniprot id: A0A2K5WF06
uniprot id: A0A2K5WF09
uniprot id: G7PBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9541:CXCL8
gene id: 9541:CXCL8
uniprot id: A0A2K5TUL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9541:LUC7L3
gene id: 9541:LUC7L3
uniprot id: A0A2K5UY02
uniprot id: A0A2K5UY32
uniprot id: G7PUB4
names: Similarity
messages: Belongs to the Luc7 family.

9541:LCN1
gene id: 9541:LCN1
uniprot id: A0A2K5X6M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9541:CYP51A1
gene id: 9541:CYP51A1
uniprot id: G7P1U1
uniprot id: Q4R8S6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Microsome membrane

9541:CAMTA2
gene id: 9541:CAMTA2
uniprot id: A0A2K5UYI2
uniprot id: A0A2K5UYJ8
uniprot id: A0A2K5UYL8
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9541:NRTN
gene id: 9541:NRTN
uniprot id: A0A2K5WLQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9541:TARS1
gene id: 9541:TARS1
uniprot id: A0A2K5VHX5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9541:OGDHL
gene id: 9541:OGDHL
uniprot id: A0A2K5UXS3
uniprot id: A0A2K5UXT3
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9541:HHIPL2
gene id: 9541:HHIPL2
uniprot id: A0A2K5W2J6
names: Similarity
messages: Belongs to the HHIP family.

9541:FLVCR1
gene id: 9541:FLVCR1
uniprot id: A0A2K5UZD8
names: Subcellular Location Annotation
messages: Membrane

9541:MUL1
gene id: 9541:MUL1
uniprot id: A0A2K5WGR6
uniprot id: G7NUU4
uniprot id: Q4R7G8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity). Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity).
messages: Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L. Interacts with MAVS. Interacts with TP53 (via N-terminus); the interaction leads to ubiquitination and proteasomal degradation of TP53.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: The zinc finger domain is required for E3 ligase activity.
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9541:ODF1
gene id: 9541:ODF1
uniprot id: A0A2K5UBQ3
uniprot id: G8F3R8
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9541:SPA17
gene id: 9541:SPA17
uniprot id: Q4R2Z5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9541:LYPLA2
gene id: 9541:LYPLA2
uniprot id: A0A2K5TMQ1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9541:YIPF2
gene id: 9541:YIPF2
uniprot id: A0A2K5X4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9541:LOC102125088
gene id: 9541:LOC102125088
uniprot id: A0A2K5UME9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9541:SEC11C
gene id: 9541:SEC11C
uniprot id: A0A8J8YDW3
uniprot id: G7PWV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:HOPX
gene id: 9541:HOPX
uniprot id: I7GIM6
names: Subcellular Location Annotation
messages: Nucleus

9541:INKA1
gene id: 9541:INKA1
uniprot id: I7GHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9541:PTX3
gene id: 9541:PTX3
uniprot id: A0A2K5WEN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:IL10
gene id: 9541:IL10
uniprot id: A0A8J8YH31
uniprot id: G7NVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9541:PREPL
gene id: 9541:PREPL
uniprot id: A0A2K5WN60
names: Similarity
messages: Belongs to the peptidase S9A family.

9541:ALKBH7
gene id: 9541:ALKBH7
uniprot id: A0A2K5WQX0
names: Similarity
messages: Belongs to the alkB family.

9541:TMEM178A
gene id: 9541:TMEM178A
uniprot id: A0A2K5V7K7
names: Similarity
messages: Belongs to the TMEM178 family.

9541:LMBR1L
gene id: 9541:LMBR1L
uniprot id: G7PHS1
uniprot id: Q4R7X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity).
messages: Endoplasmic reticulum membrane
messages: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity).

9541:SERPINA1
gene id: 9541:SERPINA1
uniprot id: A0A2K5VCH9
uniprot id: G7PBD8
names: Similarity
messages: Belongs to the serpin family.

9541:FBLN1
gene id: 9541:FBLN1
uniprot id: A0A2K5VCN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:LTA4H
gene id: 9541:LTA4H
uniprot id: A0A2K5U9C9
uniprot id: G7PJ36
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9541:LOC102140676
gene id: 9541:LOC102140676
uniprot id: A0A2K5ULD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KCNJ12
gene id: 9541:KCNJ12
uniprot id: A0A7N9D225
uniprot id: A0A8J8XCB5
uniprot id: G7PTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9541:TWF1
gene id: 9541:TWF1
uniprot id: A0A2K5TZ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9541:LOC102136972
gene id: 9541:LOC102136972
uniprot id: A0A2K5WX78
uniprot id: A0A8J8XVQ5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9541:GABRG3
gene id: 9541:GABRG3
uniprot id: A0A2K5WT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:CA3
gene id: 9541:CA3
uniprot id: I7GN11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9541:ARSF
gene id: 9541:ARSF
uniprot id: A0A2K5TQG2
names: Similarity
messages: Belongs to the sulfatase family.

9541:LOC102140788
gene id: 9541:LOC102140788
uniprot id: G7P624
uniprot id: P61256
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9541:NSUN5
gene id: 9541:NSUN5
uniprot id: A0A2K5WIR5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9541:NR2F1
gene id: 9541:NR2F1
uniprot id: A0A2K5VYC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:LEPR
gene id: 9541:LEPR
uniprot id: A0A2K5U8P7
uniprot id: A0A2K5U8T0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9541:LOC107129593
gene id: 9541:LOC107129593
uniprot id: A0A8U0WQ25
uniprot id: G8F3V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:MS4A8
gene id: 9541:MS4A8
uniprot id: A0A2K5TY64
uniprot id: G7PPZ8
names: Similarity
messages: Belongs to the MS4A family.

9541:AGK
gene id: 9541:AGK
uniprot id: A0A2K5WYW0
uniprot id: G7P1E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:DTX2
gene id: 9541:DTX2
uniprot id: A0A2K5W5A6
uniprot id: A0A2K5W5C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9541:DPYD
gene id: 9541:DPYD
uniprot id: A0A2K5V8G2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9541:MAF1
gene id: 9541:MAF1
uniprot id: A0A2K5UNZ7
uniprot id: A0A8J8XHI8
uniprot id: G7PDA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9541:CD81
gene id: 9541:CD81
uniprot id: A0A2K5UDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:NFYB
gene id: 9541:NFYB
uniprot id: A0A2K5TK75
uniprot id: A0A2K5TKA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9541:CHCHD4
gene id: 9541:CHCHD4
uniprot id: A0A2K5VLP3
uniprot id: A0A8J8XW51
uniprot id: G7PIL3
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9541:GPR182
gene id: 9541:GPR182
uniprot id: G7PIU3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CACNA1S
gene id: 9541:CACNA1S
uniprot id: A0A8J8XWF9
uniprot id: G7NWG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9541:EVPL
gene id: 9541:EVPL
uniprot id: A0A2K5X342
names: Subcellular Location Annotation
messages: cytoskeleton

9541:EZH1
gene id: 9541:EZH1
uniprot id: A0A2K5V0B8
names: Subcellular Location Annotation
messages: Nucleus

9541:CTDP1
gene id: 9541:CTDP1
uniprot id: A0A2K5UY30
uniprot id: A0A2K5UY78
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9541:DUSP7
gene id: 9541:DUSP7
uniprot id: A0A2K5X0H0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:KANSL2
gene id: 9541:KANSL2
uniprot id: A0A2K5TRC0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9541:ACTR1B
gene id: 9541:ACTR1B
uniprot id: A0A2K5UMH2
names: Similarity
messages: Belongs to the actin family.

9541:SEM1
gene id: 9541:SEM1
uniprot id: A0A8J8XZN6
uniprot id: G7P1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9541:ADAT2
gene id: 9541:ADAT2
uniprot id: A0A8J8XYR1
uniprot id: G7P308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Cytoplasm
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9541:FGF3
gene id: 9541:FGF3
uniprot id: A0A2K5TKR2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:GLYR1
gene id: 9541:GLYR1
uniprot id: A0A2K5V2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9541:SLFNL1
gene id: 9541:SLFNL1
uniprot id: Q4R3B7
names: Similarity
messages: Belongs to the Schlafen family. Subgroup I subfamily.

9541:PSMC5
gene id: 9541:PSMC5
uniprot id: I7G7U1
uniprot id: I7GHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9541:DUOX2
gene id: 9541:DUOX2
uniprot id: A0A2K5UNL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9541:RPTOR
gene id: 9541:RPTOR
uniprot id: A0A2K5TPP8
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9541:RPL26L1
gene id: 9541:RPL26L1
uniprot id: A0A2K5W0P7
uniprot id: G7P6X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9541:EMG1
gene id: 9541:EMG1
uniprot id: A0A8J8XFU7
uniprot id: G7PJP2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9541:BMX
gene id: 9541:BMX
uniprot id: A0A2K5UVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:PYCR1
gene id: 9541:PYCR1
uniprot id: A0A2K5TMQ2
uniprot id: A0A8J8YL72
uniprot id: G7PT60
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9541:PIWIL3
gene id: 9541:PIWIL3
uniprot id: G7PHF0
names: Similarity
messages: Belongs to the argonaute family.

9541:GPT2
gene id: 9541:GPT2
uniprot id: A0A2K5V631
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9541:TMEM266
gene id: 9541:TMEM266
uniprot id: Q9N0B5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Perikaryon
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.
messages: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
messages: dendrite

9541:PRPH2
gene id: 9541:PRPH2
uniprot id: A0A2K5WJM1
uniprot id: G7P3Y4
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9541:TMEM251
gene id: 9541:TMEM251
uniprot id: A0A2K5VWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

9541:CDK5RAP2
gene id: 9541:CDK5RAP2
uniprot id: A0A2K5U237
uniprot id: A0A2K5U2C2
names: Subcellular Location Annotation
messages: centrosome

9541:TMEM14B
gene id: 9541:TMEM14B
uniprot id: A0A2K5VR23
uniprot id: A0A2K5VR38
names: Similarity
messages: Belongs to the TMEM14 family.

9541:LOC102138425
gene id: 9541:LOC102138425
uniprot id: G8F3E6
names: Similarity
messages: Belongs to the LCE family.

9541:LOC102141746
gene id: 9541:LOC102141746
uniprot id: A0A2K5TRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:TMEM225B
gene id: 9541:TMEM225B
uniprot id: A0A2K5VT89
names: Subcellular Location Annotation
messages: Membrane

9541:AHCYL1
gene id: 9541:AHCYL1
uniprot id: A0A2K5VMN0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9541:MTMR2
gene id: 9541:MTMR2
uniprot id: A0A2K5TPM1
uniprot id: A0A7N9IAS5
uniprot id: A0A8J8XPP1
uniprot id: G7PNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9541:TACC2
gene id: 9541:TACC2
uniprot id: A0A2K5X191
uniprot id: A0A2K5X1C0
uniprot id: A0A2K5X1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9541:TRIM36
gene id: 9541:TRIM36
uniprot id: A0A2K5VUQ5
uniprot id: A0A7N9DBA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9541:CELA1
gene id: 9541:CELA1
uniprot id: O46644
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts upon elastin.
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:RHBDD3
gene id: 9541:RHBDD3
uniprot id: A0A2K5VHH7
uniprot id: G7PHH6
names: Subcellular Location Annotation
messages: Membrane

9541:PDPR
gene id: 9541:PDPR
uniprot id: G7Q1M1
names: Similarity
messages: Belongs to the GcvT family.

9541:AMER1
gene id: 9541:AMER1
uniprot id: G7Q2W4
names: Similarity
messages: Belongs to the Amer family.

9541:ADGRB3
gene id: 9541:ADGRB3
uniprot id: A0A2K5WCB3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NAA20
gene id: 9541:NAA20
uniprot id: Q2PFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
messages: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
messages: Cytoplasm
messages: Nucleus

9541:PIK3C2G
gene id: 9541:PIK3C2G
uniprot id: A0A2K5UGN7
uniprot id: A0A2K5UGT4
uniprot id: A0A2K5UGU0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:RNF34
gene id: 9541:RNF34
uniprot id: A0A2K5W4E9
uniprot id: A0A2K5W4G1
names: Subcellular Location Annotation
messages: Cell membrane

9541:LOC102139855
gene id: 9541:LOC102139855
uniprot id: A0A2K5TKU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9541:NMBR
gene id: 9541:NMBR
uniprot id: A0A2K5WCN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PTK2B
gene id: 9541:PTK2B
uniprot id: A0A2K5WCI3
uniprot id: A0A2K5WCJ3
uniprot id: A0A2K5WCP6
uniprot id: A0A2K5WCQ3
uniprot id: A0A8J8Y222
uniprot id: G7PCY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9541:SDAD1
gene id: 9541:SDAD1
uniprot id: A0A2K5WP56
uniprot id: A0A2K5WPA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9541:G6PD
gene id: 9541:G6PD
uniprot id: A0A2K5VEE8
uniprot id: A0A7N9CPQ8
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9541:TM4SF1
gene id: 9541:TM4SF1
uniprot id: Q95LS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9541:CLDN22
gene id: 9541:CLDN22
uniprot id: A0A2K5UF63
uniprot id: G7P6L6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:ITIH3
gene id: 9541:ITIH3
uniprot id: A0A2K5WPG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9541:RPS19
gene id: 9541:RPS19
uniprot id: Q25PV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9541:TNFSF15
gene id: 9541:TNFSF15
uniprot id: A0A2K5UA22
uniprot id: G7PRK8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:LOC102144945
gene id: 9541:LOC102144945
uniprot id: A0A2K5UMA0
names: Subcellular Location Annotation
messages: Membrane

9541:IGF1R
gene id: 9541:IGF1R
uniprot id: A0A2K5W796
uniprot id: G7P9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9541:LOC102137003
gene id: 9541:LOC102137003
uniprot id: A0A2K5TT95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9541:ELAVL1
gene id: 9541:ELAVL1
uniprot id: Q4R855
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9541:EN1
gene id: 9541:EN1
uniprot id: A0A2K5X3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9541:SNX32
gene id: 9541:SNX32
uniprot id: A0A2K5WB75
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9541:ITPR3
gene id: 9541:ITPR3
uniprot id: A0A2K5WYE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9541:ADGRL2
gene id: 9541:ADGRL2
uniprot id: A0A2K5TQ03
uniprot id: A0A2K5TQ12
uniprot id: A0A2K5TQ63
names: Subcellular Location Annotation
messages: Membrane

9541:SF3A2
gene id: 9541:SF3A2
uniprot id: A0A2K5U0V7
names: Similarity
messages: Belongs to the SF3A2 family.

9541:AP3M1
gene id: 9541:AP3M1
uniprot id: A0A2K5VTF2
uniprot id: A0A8J8YQP0
uniprot id: G7PEZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9541:CALHM1
gene id: 9541:CALHM1
uniprot id: G7PDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:ARPC5
gene id: 9541:ARPC5
uniprot id: Q4R5N7
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9541:MMP26
gene id: 9541:MMP26
uniprot id: A0A2K5WUI9
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:DHODH
gene id: 9541:DHODH
uniprot id: A0A2K5VJ86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9541:CATSPERE
gene id: 9541:CATSPERE
uniprot id: A0A2K5V8Y1
names: Similarity
messages: Belongs to the CATSPERD family.

9541:SLC14A2
gene id: 9541:SLC14A2
uniprot id: A0A2K5V7Z1
uniprot id: G7PWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9541:POLL
gene id: 9541:POLL
uniprot id: A0A2K5VDF5
uniprot id: A0A8J8Y921
uniprot id: E5FGI8
uniprot id: Q4R380
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Interacts with PCNA. Interacts with PAXX; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with XRCC4; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with NHEJ1/XLF; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL.
messages: Nucleus

9541:ASRGL1
gene id: 9541:ASRGL1
uniprot id: G7PPU6
uniprot id: Q4R7U8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Cytoplasm
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9541:ZFHX2
gene id: 9541:ZFHX2
uniprot id: A0A2K5UJ81
names: Subcellular Location Annotation
messages: Nucleus

9541:PROK2
gene id: 9541:PROK2
uniprot id: A0A2K5WC32
uniprot id: A0A2K5WC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9541:ICAM1
gene id: 9541:ICAM1
uniprot id: A0A2K5UKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9541:VPS52
gene id: 9541:VPS52
uniprot id: A0A2K5TRI0
uniprot id: A0A7N9D492
names: Similarity
messages: Belongs to the VPS52 family.

9541:MAP2K4
gene id: 9541:MAP2K4
uniprot id: A0A2K5WTM3
uniprot id: I7GDS3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:RIMBP2
gene id: 9541:RIMBP2
uniprot id: A0A2K5VWX6
uniprot id: A0A2K5VWY3
names: Similarity
messages: Belongs to the RIMBP family.

9541:XRCC6
gene id: 9541:XRCC6
uniprot id: A0A8J8YAA5
uniprot id: Q4R673
uniprot id: Q4R829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9541:PRDM14
gene id: 9541:PRDM14
uniprot id: A0A2K5VQS2
uniprot id: A0A8J8YSJ2
uniprot id: G7PC03
names: Subcellular Location Annotation
messages: Nucleus

9541:TRPC7
gene id: 9541:TRPC7
uniprot id: A0A2K5TUF7
names: Subcellular Location Annotation
messages: Membrane

9541:PLCD4
gene id: 9541:PLCD4
uniprot id: A0A2K5UTL5
uniprot id: A0A2K5UTM9
uniprot id: Q4R6L3
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Interacts with GRIP1 (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); low-affinity interaction (By similarity).
messages: Membrane
messages: Nucleus
messages: The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
messages: The PDZ-binding motif mediates the interaction with GRIP1.
messages: The PH domain is not a critical determinant of the membrane localization.

9541:KRT74
gene id: 9541:KRT74
uniprot id: A0A2K5UX57
names: Similarity
messages: Belongs to the intermediate filament family.

9541:AQP7
gene id: 9541:AQP7
uniprot id: Q4R691
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (By similarity). The channel is also permeable to urea (By similarity). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).
messages: Homotetramer. Interacts (via N-terminus) with PLIN1.
messages: Lipid droplet
messages: cell cortex

9541:GPR180
gene id: 9541:GPR180
uniprot id: A0A2K5VJ87
uniprot id: G7PVL1
names: Subcellular Location Annotation
messages: Membrane

9541:DYNLRB1
gene id: 9541:DYNLRB1
uniprot id: A0A2K5U3W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9541:IL17C
gene id: 9541:IL17C
uniprot id: A0A2K5X1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9541:PHC3
gene id: 9541:PHC3
uniprot id: A0A2K5U5F6
uniprot id: A0A2K5U5L1
uniprot id: G7NZF5
names: Subcellular Location Annotation
messages: Nucleus

9541:TCF25
gene id: 9541:TCF25
uniprot id: A0A2K5WUL5
names: Similarity
messages: Belongs to the TCF25 family.

9541:TASP1
gene id: 9541:TASP1
uniprot id: I7G6M1
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9541:NR2E1
gene id: 9541:NR2E1
uniprot id: A0A2K5TWE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:ENGASE
gene id: 9541:ENGASE
uniprot id: A0A2K5WE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9541:EVA1A
gene id: 9541:EVA1A
uniprot id: A0A2K5UI30
uniprot id: G7PMK7
names: Similarity
messages: Belongs to the EVA1 family.

9541:LOC102125186
gene id: 9541:LOC102125186
uniprot id: Q4R882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:PDYN
gene id: 9541:PDYN
uniprot id: A0A7N9I981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9541:OSBPL8
gene id: 9541:OSBPL8
uniprot id: A0A2K5TKF4
uniprot id: A0A2K5TKK1
uniprot id: A0A2K5TKK3
uniprot id: A0A8J8XM37
uniprot id: G7PI36
names: Similarity
messages: Belongs to the OSBP family.

9541:ACTN4
gene id: 9541:ACTN4
uniprot id: A0A2K5TSR0
uniprot id: A0A2K5TSR3
names: Similarity
messages: Belongs to the alpha-actinin family.

9541:IGFBP5
gene id: 9541:IGFBP5
uniprot id: G7PLE3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:TAF6L
gene id: 9541:TAF6L
uniprot id: A0A2K5USE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9541:GPN3
gene id: 9541:GPN3
uniprot id: A0A2K5W7R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9541:CCL8
gene id: 9541:CCL8
uniprot id: G7PU24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:SLC25A18
gene id: 9541:SLC25A18
uniprot id: A0A2K5X2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:ACE2
gene id: 9541:ACE2
uniprot id: A0A2K5X283
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9541:LOC107129591
gene id: 9541:LOC107129591
uniprot id: G7P2L6
uniprot id: G7P2M7
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:BTK
gene id: 9541:BTK
uniprot id: A0A2K5VDZ2
uniprot id: G7Q392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:LIMS2
gene id: 9541:LIMS2
uniprot id: A0A2K5U9V6
uniprot id: A0A2K5U9X0
uniprot id: I7G9V9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9541:ZFYVE27
gene id: 9541:ZFYVE27
uniprot id: A0A2K5UY58
uniprot id: A0A2K5UY62
uniprot id: A0A2K5UY92
uniprot id: A0A2K5UYA6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9541:FCHO2
gene id: 9541:FCHO2
uniprot id: A0A2K5USL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9541:KCND3
gene id: 9541:KCND3
uniprot id: A0A2K5TXA6
uniprot id: A0A8J8XCK3
uniprot id: G7NW61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9541:NUMB
gene id: 9541:NUMB
uniprot id: A0A2K5WTY1
uniprot id: A0A2K5WTY3
uniprot id: A0A2K5WTZ1
uniprot id: G7PAT2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9541:ATP13A3
gene id: 9541:ATP13A3
uniprot id: A0A2K5X2G1
uniprot id: Q95JN5
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Early endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: Recycling endosome membrane

9541:SORL1
gene id: 9541:SORL1
uniprot id: A0A2K5UVA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9541:LOC102130580
gene id: 9541:LOC102130580
uniprot id: A0A2K5X0B4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9541:INTS14
gene id: 9541:INTS14
uniprot id: A0A2K5UXJ3
uniprot id: A0A2K5UXS0
uniprot id: I7G7P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9541:PNPT1
gene id: 9541:PNPT1
uniprot id: A0A2K5TWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

9541:CSE1L
gene id: 9541:CSE1L
uniprot id: A0A2K5WF48
uniprot id: A0A8J8YQ05
uniprot id: G7PG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9541:APOA5
gene id: 9541:APOA5
uniprot id: A0A2K5WP26
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9541:HIBCH
gene id: 9541:HIBCH
uniprot id: A0A2K5VSZ9
uniprot id: I7G8D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9541:KAT2B
gene id: 9541:KAT2B
uniprot id: G7NY79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

9541:NAP1L1
gene id: 9541:NAP1L1
uniprot id: A0A2K5TUU8
uniprot id: A0A2K5TUV1
uniprot id: I7GLJ2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:TRIP12
gene id: 9541:TRIP12
uniprot id: A0A2K5W101
uniprot id: A0A2K5W1A1
uniprot id: A0A7N9CWS4
uniprot id: G7PK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9541:MAP1LC3B
gene id: 9541:MAP1LC3B
uniprot id: A0A7N9C6Y1
uniprot id: Q4R530
names: Similarity
messages: Belongs to the ATG8 family.

9541:FAM221A
gene id: 9541:FAM221A
uniprot id: A0A2K5WRE7
names: Similarity
messages: Belongs to the FAM221 family.

9541:GNG3
gene id: 9541:GNG3
uniprot id: A0A8J8XIX8
uniprot id: G7PPT4
uniprot id: I7GMQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:TTC19
gene id: 9541:TTC19
uniprot id: A0A2K5WHX8
names: Similarity
messages: Belongs to the TTC19 family.

9541:AGBL3
gene id: 9541:AGBL3
uniprot id: A0A2K5UME5
uniprot id: A0A2K5UMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9541:ATP12A
gene id: 9541:ATP12A
uniprot id: A0A2K5UEJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SLC5A4
gene id: 9541:SLC5A4
uniprot id: A0A2K5U3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9541:KCNA1
gene id: 9541:KCNA1
uniprot id: A0A2K5UKT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:BRINP1
gene id: 9541:BRINP1
uniprot id: A0A8J8YF47
uniprot id: G7PRK2
names: Similarity
messages: Belongs to the BRINP family.

9541:PPP3CB
gene id: 9541:PPP3CB
uniprot id: I7GIS6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9541:RBM48
gene id: 9541:RBM48
uniprot id: A0A2K5UMQ6
names: Similarity
messages: Belongs to the RBM48 family.

9541:IDO1
gene id: 9541:IDO1
uniprot id: A0A2K5TU13
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9541:IZUMO1
gene id: 9541:IZUMO1
uniprot id: A0A2K5UGJ7
names: Similarity
messages: Belongs to the Izumo family.

9541:ACTL7A
gene id: 9541:ACTL7A
uniprot id: A0A2K5UD76
uniprot id: Q4R6Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer. Interacts with ACTL9.
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9541:SLC16A9
gene id: 9541:SLC16A9
uniprot id: A0A8J8YS42
uniprot id: G7PDF0
names: Subcellular Location Annotation
messages: Membrane

9541:DES
gene id: 9541:DES
uniprot id: B3Y602
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MARF1
gene id: 9541:MARF1
uniprot id: A0A2K5TUD8
names: Subcellular Location Annotation
messages: Peroxisome

9541:SLC25A19
gene id: 9541:SLC25A19
uniprot id: G7PST1
uniprot id: Q5IS35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.
messages: Mitochondrion membrane
messages: Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier.

9541:ACAD8
gene id: 9541:ACAD8
uniprot id: A0A2K5WP11
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:CACNG3
gene id: 9541:CACNG3
uniprot id: A0A2K5WLZ1
uniprot id: G7Q0R3
uniprot id: Q4R589
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
messages: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons.

9541:IFT43
gene id: 9541:IFT43
uniprot id: A0A7N9CSQ0
names: Similarity
messages: Belongs to the IFT43 family.

9541:COPB1
gene id: 9541:COPB1
uniprot id: A0A8J8XMC7
uniprot id: G7PQN7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9541:TMPRSS2
gene id: 9541:TMPRSS2
uniprot id: A0A2K5VQI7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GRAMD1B
gene id: 9541:GRAMD1B
uniprot id: A0A2K5UJ93
uniprot id: A0A2K5UJJ0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:NDST3
gene id: 9541:NDST3
uniprot id: A0A2K5WFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:JAGN1
gene id: 9541:JAGN1
uniprot id: A0A2K5WLU3
uniprot id: G8F652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TENT5B
gene id: 9541:TENT5B
uniprot id: A0A2K5WBP7
names: Similarity
messages: Belongs to the TENT family.

9541:GNAI2
gene id: 9541:GNAI2
uniprot id: Q4R592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (By similarity). Interacts with UNC5B (By similarity). Interacts with GPSM1 (By similarity). Interacts with RGS12 and RGS14 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity). Interacts with CXCR1 and CXCR2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
messages: Membrane
messages: Ubiquitously expressed. Most abundant in the lung and in the spleen.
messages: centrosome

9541:OTUB2
gene id: 9541:OTUB2
uniprot id: A0A2K5VJQ2
names: Similarity
messages: Belongs to the peptidase C65 family.

9541:S100A4
gene id: 9541:S100A4
uniprot id: A0A2K5WBB8
uniprot id: A0A8J8Y4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:TMEM17
gene id: 9541:TMEM17
uniprot id: A0A7N9IHF4
names: Subcellular Location Annotation
messages: Membrane

9541:SERPIND1
gene id: 9541:SERPIND1
uniprot id: A0A2K5UTW1
uniprot id: G7PHA8
names: Similarity
messages: Belongs to the serpin family.

9541:PITHD1
gene id: 9541:PITHD1
uniprot id: I7G9N5
names: Similarity
messages: Belongs to the PITHD1 family.

9541:LOC102115270
gene id: 9541:LOC102115270
uniprot id: A0A2K5UWW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9541:CCN2
gene id: 9541:CCN2
uniprot id: I7G525
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:NDUFV3
gene id: 9541:NDUFV3
uniprot id: A0A2K5VMZ4
uniprot id: A0A2K5VN19
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9541:LOC102116507
gene id: 9541:LOC102116507
uniprot id: A0A2K5UE54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:WASHC3
gene id: 9541:WASHC3
uniprot id: A0A2K5UGQ0
uniprot id: G7PJB6
names: Similarity
messages: Belongs to the CCDC53 family.

9541:OGG1
gene id: 9541:OGG1
uniprot id: A0A2K5X0W2
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9541:LOC102133131
gene id: 9541:LOC102133131
uniprot id: A0A2K5W2C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9541:LOC102122055
gene id: 9541:LOC102122055
uniprot id: A0A2K5WUZ3
uniprot id: G7PRL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9541:ST6GALNAC2
gene id: 9541:ST6GALNAC2
uniprot id: A0A2K5VUC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:NUBP2
gene id: 9541:NUBP2
uniprot id: A0A2K5W4T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9541:TXNL4B
gene id: 9541:TXNL4B
uniprot id: A0A7N9IA00
uniprot id: A0A8J8YJA8
uniprot id: G7Q1J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9541:UBE2F
gene id: 9541:UBE2F
uniprot id: A0A2K5VB43
uniprot id: A0A2K5VB62
uniprot id: A0A2K5VBA5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:TNFSF14
gene id: 9541:TNFSF14
uniprot id: E9NVF7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:FGD3
gene id: 9541:FGD3
uniprot id: A0A2K5TZX8
names: Subcellular Location Annotation
messages: cytoskeleton

9541:UTP15
gene id: 9541:UTP15
uniprot id: A0A2K5UYR7
names: Subcellular Location Annotation
messages: nucleolus

9541:RRAD
gene id: 9541:RRAD
uniprot id: A0A2K5V2G5
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9541:RTN4R
gene id: 9541:RTN4R
uniprot id: Q9N0E3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nogo receptor family.
messages: Cell membrane
messages: Homodimer. Interacts with MAG (By similarity). Interacts with RTN4 (By similarity). Interacts with NGFR. Interacts with LINGO1. Interacts with KIAA0319L (By similarity). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity).
messages: Membrane raft
messages: N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
messages: Perikaryon
messages: Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (By similarity). Interacts with OMG (By similarity).
messages: axon
messages: dendrite

9541:EIF3G
gene id: 9541:EIF3G
uniprot id: A0A2K5WAN0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9541:BRMS1
gene id: 9541:BRMS1
uniprot id: I7GCX1
names: Subcellular Location Annotation
messages: Nucleus

9541:HEPH
gene id: 9541:HEPH
uniprot id: A0A2K5WZ73
uniprot id: G7Q2X1
names: Similarity
messages: Belongs to the multicopper oxidase family.

9541:SFMBT1
gene id: 9541:SFMBT1
uniprot id: A0A2K5W642
names: Subcellular Location Annotation
messages: Nucleus

9541:EME1
gene id: 9541:EME1
uniprot id: A0A2K5TQQ7
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9541:GALNT16
gene id: 9541:GALNT16
uniprot id: A0A2K5WDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:HSD17B13
gene id: 9541:HSD17B13
uniprot id: A0A8J8YIB5
uniprot id: G7P5V3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:TMEM38A
gene id: 9541:TMEM38A
uniprot id: G7PZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9541:TNFRSF21
gene id: 9541:TNFRSF21
uniprot id: A0A2K5VIJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PPCS
gene id: 9541:PPCS
uniprot id: A0A2K5TRD4
names: Similarity
messages: Belongs to the PPC synthetase family.

9541:SSTR2
gene id: 9541:SSTR2
uniprot id: A0A2K5UNX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9541:LOC102132378
gene id: 9541:LOC102132378
uniprot id: A0A2K5VHV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9541:RFX3
gene id: 9541:RFX3
uniprot id: A0A2K5X7D6
uniprot id: A0A2K5X7G5
uniprot id: A0A2K5X7I3
uniprot id: G7PSF9
names: Subcellular Location Annotation
messages: Nucleus

9541:TUFM
gene id: 9541:TUFM
uniprot id: A0A2K5W255
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9541:LOC102126513
gene id: 9541:LOC102126513
uniprot id: A0A2K5ULW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TMEM9
gene id: 9541:TMEM9
uniprot id: Q4R576
names: Similarity
messages: Belongs to the TMEM9 family.

9541:GRID1
gene id: 9541:GRID1
uniprot id: A0A2K5WKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:SLC25A1
gene id: 9541:SLC25A1
uniprot id: A0A2K5VBI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:ELOVL3
gene id: 9541:ELOVL3
uniprot id: A0A8J8Y4P6
uniprot id: G7PDU3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9541:LOC102142998
gene id: 9541:LOC102142998
uniprot id: A0A023JCC0
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9541:LOC102121169
gene id: 9541:LOC102121169
uniprot id: A0A2K5VYZ3
uniprot id: B3Y689
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9541:GPX7
gene id: 9541:GPX7
uniprot id: A0A2K5VXA5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9541:RNASEH1
gene id: 9541:RNASEH1
uniprot id: A0A2K5TLI4
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9541:IL1RL2
gene id: 9541:IL1RL2
uniprot id: A0A2K5WSK9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:TMEM134
gene id: 9541:TMEM134
uniprot id: A0A2K5UPZ8
uniprot id: A0A2K5UQ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9541:TIMP3
gene id: 9541:TIMP3
uniprot id: P61269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).
messages: Interacts with EFEMP1.
messages: extracellular matrix

9541:LOC101925710
gene id: 9541:LOC101925710
uniprot id: A0A8J8XMW9
uniprot id: G7NZK0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:TMBIM4
gene id: 9541:TMBIM4
uniprot id: A0A2K5UQC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9541:SCN5A
gene id: 9541:SCN5A
uniprot id: A0A2K5WYW9
uniprot id: A0A2K5WZD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:SGK2
gene id: 9541:SGK2
uniprot id: A0A2K5V2R8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LSS
gene id: 9541:LSS
uniprot id: A0A2K5TLI2
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

9541:CYP26B1
gene id: 9541:CYP26B1
uniprot id: A0A7N9IG73
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:MACIR
gene id: 9541:MACIR
uniprot id: A0A8J8YQW5
uniprot id: G7P810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9541:SLC25A23
gene id: 9541:SLC25A23
uniprot id: A0A2K5X467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:NPR3
gene id: 9541:NPR3
uniprot id: A0A2K5VGJ2
uniprot id: A0A2K5VGJ7
names: Subcellular Location Annotation
messages: Membrane

9541:SLC25A14
gene id: 9541:SLC25A14
uniprot id: A0A2K5V243
uniprot id: I7GMB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LDHB
gene id: 9541:LDHB
uniprot id: G7PCH4
uniprot id: I7GKK2
uniprot id: Q4R5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

9541:ATP1A3
gene id: 9541:ATP1A3
uniprot id: A0A2K5X6F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9541:CLDN6
gene id: 9541:CLDN6
uniprot id: G7Q0B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:BCL7C
gene id: 9541:BCL7C
uniprot id: A0A2K5V193
uniprot id: A0A2K5V1A2
names: Similarity
messages: Belongs to the BCL7 family.

9541:FAM102B
gene id: 9541:FAM102B
uniprot id: A0A2K5X5M4
uniprot id: G8F4J1
names: Similarity
messages: Belongs to the FAM102 family.

9541:FERMT3
gene id: 9541:FERMT3
uniprot id: A0A2K5U8F3
names: Similarity
messages: Belongs to the kindlin family.

9541:SCRN1
gene id: 9541:SCRN1
uniprot id: A0A2K5W4I0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9541:LOC102124330
gene id: 9541:LOC102124330
uniprot id: A0A2K5W6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:EDA2R
gene id: 9541:EDA2R
uniprot id: A0A2K5TKN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC101866303
gene id: 9541:LOC101866303
uniprot id: A0A2K5TZS8
uniprot id: A0A8J8XJ50
uniprot id: G7PHC8
names: Similarity
messages: Belongs to the PRAME family.

9541:MRFAP1L1
gene id: 9541:MRFAP1L1
uniprot id: A0A2K5UET2
uniprot id: G7P578
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9541:SPATS2L
gene id: 9541:SPATS2L
uniprot id: A0A2K5WAB6
uniprot id: A0A2K5WAB9
uniprot id: G7PL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9541:MEIS2
gene id: 9541:MEIS2
uniprot id: A0A2K5UKT5
uniprot id: I7GEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9541:GCM1
gene id: 9541:GCM1
uniprot id: A0A2K5ULM4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102122997
gene id: 9541:LOC102122997
uniprot id: A0A2K5VPS1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:EXT1
gene id: 9541:EXT1
uniprot id: A0A2K5TXF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

9541:LOC102123456
gene id: 9541:LOC102123456
uniprot id: A0A2K5VCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9541:ANXA7
gene id: 9541:ANXA7
uniprot id: A0A2K5VHK9
uniprot id: Q4R5L5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
messages: Interacts with PDCD6.

9541:CLDN11
gene id: 9541:CLDN11
uniprot id: G7NZF2
uniprot id: Q4R3L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Interacts with tetraspanin-3/TSPAN3. Interacts with OCLN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:NEK8
gene id: 9541:NEK8
uniprot id: A0A2K5WSY6
uniprot id: G7PTY4
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9541:LOC102135422
gene id: 9541:LOC102135422
uniprot id: A0A2K5X0X8
uniprot id: A0A2K5X143
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9541:PLAGL2
gene id: 9541:PLAGL2
uniprot id: A0A7N9D9R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9541:C9
gene id: 9541:C9
uniprot id: A0A2K5X2W7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

9541:ACTR8
gene id: 9541:ACTR8
uniprot id: A0A8J8YT00
uniprot id: G7NZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9541:DNALI1
gene id: 9541:DNALI1
uniprot id: Q4R3K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inner dynein arm light chain family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with CFAP45 (By similarity). Interacts with DYNC1H1 (By similarity).
messages: May play a dynamic role in flagellar motility.
messages: cilium
messages: flagellum

9541:TSPAN33
gene id: 9541:TSPAN33
uniprot id: A0A2K5WNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:SNX25
gene id: 9541:SNX25
uniprot id: A0A2K5WIU5
uniprot id: A0A7N9CPW6
uniprot id: G7P6N5
names: Similarity
messages: Belongs to the sorting nexin family.

9541:DNM3
gene id: 9541:DNM3
uniprot id: A0A2K5TS56
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9541:SF3B5
gene id: 9541:SF3B5
uniprot id: A0A2K5UMW7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9541:SDHD
gene id: 9541:SDHD
uniprot id: A0A2K5VD68
uniprot id: A0A2K5VDD8
uniprot id: A0A8J8XED5
uniprot id: G7PNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9541:LOC102136518
gene id: 9541:LOC102136518
uniprot id: A0A2K5W2L6
uniprot id: I7G2L7
names: Similarity
messages: Belongs to the MHC class I family.

9541:GABBR2
gene id: 9541:GABBR2
uniprot id: A0A2K5VY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:TMEFF1
gene id: 9541:TMEFF1
uniprot id: A0A2K5UDS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FDXR
gene id: 9541:FDXR
uniprot id: A0A2K5VSG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9541:LOC102120794
gene id: 9541:LOC102120794
uniprot id: A0A2K5V8L2
names: Similarity
messages: Belongs to the S-100 family.

9541:LOC101865459
gene id: 9541:LOC101865459
uniprot id: Q4R3A6
names: Caution
messages: Product of a dubious CDS prediction. May be a non-coding RNA.

9541:FADS3
gene id: 9541:FADS3
uniprot id: A0A2K5TRV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9541:HSP90AB1
gene id: 9541:HSP90AB1
uniprot id: Q4R4T5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylatio…
messages: Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interac…
messages: Nucleus
messages: Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
messages: S-nitrosylated; negatively regulates the ATPase activity.
messages: Secreted
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).

9541:LRP1
gene id: 9541:LRP1
uniprot id: A0A2K5X4Q3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SH2B1
gene id: 9541:SH2B1
uniprot id: A0A2K5TVT4
names: Similarity
messages: Belongs to the SH2B adapter family.

9541:POLR3D
gene id: 9541:POLR3D
uniprot id: A0A2K5UM89
uniprot id: G7PCV0
names: Subcellular Location Annotation
messages: Nucleus

9541:LMOD3
gene id: 9541:LMOD3
uniprot id: A0A2K5VLR2
names: Subcellular Location Annotation
messages: cytoskeleton

9541:GANC
gene id: 9541:GANC
uniprot id: A0A2K5W0E6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9541:MIGA1
gene id: 9541:MIGA1
uniprot id: A0A2K5VYJ8
uniprot id: A0A7N9CBP6
names: Similarity
messages: Belongs to the mitoguardin family.

9541:APOBEC3C
gene id: 9541:APOBEC3C
uniprot id: I7GI38
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CSTF1
gene id: 9541:CSTF1
uniprot id: A0A8J8YE71
uniprot id: Q4R7X3
names: Subcellular Location Annotation
messages: Nucleus

9541:FABP5
gene id: 9541:FABP5
uniprot id: A0A2K5VFN5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:SLC25A51
gene id: 9541:SLC25A51
uniprot id: A0A7N9CMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LOC102131468
gene id: 9541:LOC102131468
uniprot id: A0A2K5TMK2
uniprot id: A0A2K5TML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9541:SEMA4G
gene id: 9541:SEMA4G
uniprot id: A0A2K5WLL7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ACVRL1
gene id: 9541:ACVRL1
uniprot id: A0A2K5WXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:RPS6KA3
gene id: 9541:RPS6KA3
uniprot id: A0A2K5VRF6
uniprot id: A0A2K5VRH3
uniprot id: A0A7N9CBN5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:MRPL52
gene id: 9541:MRPL52
uniprot id: A0A2K5X932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9541:RHAG
gene id: 9541:RHAG
uniprot id: O77484
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9541:MOSPD1
gene id: 9541:MOSPD1
uniprot id: A0A2K5X4V4
uniprot id: A0A2K5X4W1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9541:FOXR2
gene id: 9541:FOXR2
uniprot id: A0A7N9CQV5
uniprot id: G8F4L6
names: Subcellular Location Annotation
messages: Nucleus

9541:MOS
gene id: 9541:MOS
uniprot id: A0A2K5UF73
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SLC25A44
gene id: 9541:SLC25A44
uniprot id: A0A8J8XAQ3
uniprot id: G7NV80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:GJD2
gene id: 9541:GJD2
uniprot id: A0A8J8YLU2
uniprot id: G7PAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:ANXA4
gene id: 9541:ANXA4
uniprot id: A0A2K5TSU0
uniprot id: A0A8J8XPJ1
uniprot id: G7PME1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9541:ERCC3
gene id: 9541:ERCC3
uniprot id: Q60HG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Belongs to the helicase family. RAD25/XPB subfamily.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. Interacts with ATF7IP. Interacts with KAT2A; leading to KAT2A recruitment to promoters and acetylation of histones.
messages: Nucleus

9541:PLCD1
gene id: 9541:PLCD1
uniprot id: A0A2K5X0S3
uniprot id: G7NYL0
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9541:SNU13
gene id: 9541:SNU13
uniprot id: Q25MP7
uniprot id: Q4R5C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
messages: Nucleus
messages: nucleolus

9541:MC2R
gene id: 9541:MC2R
uniprot id: G7PWB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

9541:SSH3
gene id: 9541:SSH3
uniprot id: A0A2K5TYZ4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9541:TAS2R39
gene id: 9541:TAS2R39
uniprot id: A0A7N9CZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:TBX19
gene id: 9541:TBX19
uniprot id: A0A2K5WKI5
uniprot id: G8F353
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:MRPS10
gene id: 9541:MRPS10
uniprot id: I7GH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9541:TRAPPC11
gene id: 9541:TRAPPC11
uniprot id: A0A2K5X5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9541:THRAP3
gene id: 9541:THRAP3
uniprot id: A0A2K5WZY3
uniprot id: A0A7N9D4M1
uniprot id: A0A7N9DCY1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9541:ATP1B2
gene id: 9541:ATP1B2
uniprot id: A0A2K5X586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:GNAI1
gene id: 9541:GNAI1
uniprot id: A0A2K5U8P3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:DDX58
gene id: 9541:DDX58
uniprot id: G7PS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9541:ADAMTS12
gene id: 9541:ADAMTS12
uniprot id: A0A2K5VYD3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:SPIN4
gene id: 9541:SPIN4
uniprot id: A0A8J8Y5W0
uniprot id: G7Q2W1
names: Similarity
messages: Belongs to the SPIN/STSY family.

9541:LOC102133993
gene id: 9541:LOC102133993
uniprot id: A0A2K5WTV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:NDNF
gene id: 9541:NDNF
uniprot id: A0A2K5WA13
uniprot id: A0A2K5WA75
names: Subcellular Location Annotation
messages: Secreted

9541:TMEM107
gene id: 9541:TMEM107
uniprot id: A0A2K5V603
names: Subcellular Location Annotation
messages: Membrane

9541:KRT78
gene id: 9541:KRT78
uniprot id: A0A2K5VZ26
uniprot id: A0A2K5VZ54
names: Similarity
messages: Belongs to the intermediate filament family.

9541:ATF1
gene id: 9541:ATF1
uniprot id: A0A8J8XPW8
uniprot id: G7PIA6
names: Subcellular Location Annotation
messages: Nucleus

9541:MYOZ2
gene id: 9541:MYOZ2
uniprot id: A0A2K5X6N6
uniprot id: G7P662
names: Similarity
messages: Belongs to the myozenin family.

9541:EPHA7
gene id: 9541:EPHA7
uniprot id: A0A8J8XWR7
uniprot id: G7P422
names: Subcellular Location Annotation
messages: Membrane

9541:GNGT1
gene id: 9541:GNGT1
uniprot id: A0A2K5TRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:LRRC8C
gene id: 9541:LRRC8C
uniprot id: A0A8J8YIA7
uniprot id: G7NTM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:TMEM201
gene id: 9541:TMEM201
uniprot id: A0A2K5WT53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9541:DPH2
gene id: 9541:DPH2
uniprot id: A0A2K5UN46
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9541:PAICS
gene id: 9541:PAICS
uniprot id: A0A2K5V7L2
uniprot id: I7G760
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9541:ERGIC2
gene id: 9541:ERGIC2
uniprot id: A0A2K5VVV1
uniprot id: A0A7N9CS93
uniprot id: Q4R5C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERGIC family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Interacts with ERGIC3, the interaction is required for the stable expression of both proteins (By similarity). May interact with EEF1A1 (By similarity).
messages: Membrane
messages: Nucleus
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: Possible role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

9541:PCSK9
gene id: 9541:PCSK9
uniprot id: A0A2K5TZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Lysosome

9541:PPFIA2
gene id: 9541:PPFIA2
uniprot id: A0A2K5UXP8
uniprot id: A0A2K5UXS7
uniprot id: A0A2K5UXU1
uniprot id: A0A2K5UXX5
uniprot id: A0A2K5UXY9
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9541:ELP2
gene id: 9541:ELP2
uniprot id: A0A2K5TTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9541:LOC102127106
gene id: 9541:LOC102127106
uniprot id: A0A2K5UDL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9541:REM2
gene id: 9541:REM2
uniprot id: A0A2K5V4C9
names: Subcellular Location Annotation
messages: Cell membrane

9541:HOXA6
gene id: 9541:HOXA6
uniprot id: A0A8J8YSD7
uniprot id: G7P0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:MAPKAPK3
gene id: 9541:MAPKAPK3
uniprot id: A0A2K5W9A9
uniprot id: G7NZY5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:GPR161
gene id: 9541:GPR161
uniprot id: A0A2K5WLY0
uniprot id: A0A2K5WLZ7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:KIZ
gene id: 9541:KIZ
uniprot id: A0A2K5TRT4
uniprot id: A0A2K5TRT6
uniprot id: A0A2K5TRU3
uniprot id: A0A2K5TRV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9541:POLR2G
gene id: 9541:POLR2G
uniprot id: A0A2K5U485
uniprot id: I7GM47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9541:AMER2
gene id: 9541:AMER2
uniprot id: A0A2K5UI73
names: Similarity
messages: Belongs to the Amer family.

9541:SNX9
gene id: 9541:SNX9
uniprot id: Q4R870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9541:CLVS2
gene id: 9541:CLVS2
uniprot id: G7P389
uniprot id: Q95KF7
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to PtdIns(3,5)P2 is not required for localization.
messages: Early endosome membrane
messages: Endosome membrane
messages: Forms a complex with clathrin heavy chain and gamma-adaptin.
messages: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
messages: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9541:GPR101
gene id: 9541:GPR101
uniprot id: A0A8J8XDN8
uniprot id: G7Q1T8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:LOC102133037
gene id: 9541:LOC102133037
uniprot id: Q4R4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9541:KCNK1
gene id: 9541:KCNK1
uniprot id: A0A2K5WVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9541:MAT2A
gene id: 9541:MAT2A
uniprot id: Q4R924
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain.

9541:ADA
gene id: 9541:ADA
uniprot id: A0A2K5VY21
uniprot id: A0A2K5VY31
uniprot id: A0A2K5VY71
uniprot id: A0A7N9DHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

9541:DEFB110
gene id: 9541:DEFB110
uniprot id: A0A2K5VRP6
uniprot id: G7P4U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:MTMR10
gene id: 9541:MTMR10
uniprot id: A0A2K5WN82
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9541:LOC102145093
gene id: 9541:LOC102145093
uniprot id: Q4R9D1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
messages: Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2.

9541:PDCD4
gene id: 9541:PDCD4
uniprot id: A0A2K5TWN0
names: Similarity
messages: Belongs to the PDCD4 family.

9541:ISL1
gene id: 9541:ISL1
uniprot id: A0A2K5VBK8
names: Subcellular Location Annotation
messages: Nucleus

9541:ZNF830
gene id: 9541:ZNF830
uniprot id: A0A2K5UJV5
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9541:RXRB
gene id: 9541:RXRB
uniprot id: A0A2K5WBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9541:GHITM
gene id: 9541:GHITM
uniprot id: A0A2K5VIA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SMPD2
gene id: 9541:SMPD2
uniprot id: A0A8J8XLY1
uniprot id: G7P3P3
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9541:CHRNA1
gene id: 9541:CHRNA1
uniprot id: A0A2K5VCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:SDHA
gene id: 9541:SDHA
uniprot id: I7GH33
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:LOC102129860
gene id: 9541:LOC102129860
uniprot id: A0A2K5UUY6
names: Similarity
messages: Belongs to the CEMIP family.

9541:GOLPH3L
gene id: 9541:GOLPH3L
uniprot id: A0A2K5VZV4
uniprot id: G8F4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:AP1S3
gene id: 9541:AP1S3
uniprot id: A0A2K5X3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9541:IFT57
gene id: 9541:IFT57
uniprot id: A0A2K5X5U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9541:GPC2
gene id: 9541:GPC2
uniprot id: A0A2K5X5G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9541:AKR1A1
gene id: 9541:AKR1A1
uniprot id: A0A2K5W354
uniprot id: A0A2K5W359
uniprot id: G8F2B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: cytosol

9541:ACTG1
gene id: 9541:ACTG1
uniprot id: Q4R4H6
names: Similarity
messages: Belongs to the actin family.

9541:KIF17
gene id: 9541:KIF17
uniprot id: A0A2K5VJL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:CNOT6L
gene id: 9541:CNOT6L
uniprot id: A0A2K5VLN0
uniprot id: A0A2K5VLN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9541:MMP28
gene id: 9541:MMP28
uniprot id: A0A2K5WAD8
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:CD2
gene id: 9541:CD2
uniprot id: Q6SZ61
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function (By similarity).
messages: Cell membrane
messages: Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity.

9541:ATL3
gene id: 9541:ATL3
uniprot id: A0A2K5VA83
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:RAP2B
gene id: 9541:RAP2B
uniprot id: A0A2K5UCT0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9541:EDN2
gene id: 9541:EDN2
uniprot id: G7NUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9541:ALDH9A1
gene id: 9541:ALDH9A1
uniprot id: A0A2K5V7N6
uniprot id: G7NU30
uniprot id: I7GA13
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:SLC50A1
gene id: 9541:SLC50A1
uniprot id: A0A2K5TV84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Membrane

9541:PEX14
gene id: 9541:PEX14
uniprot id: I7GKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9541:HECTD1
gene id: 9541:HECTD1
uniprot id: A0A2K5WKG5
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9541:LOC102120544
gene id: 9541:LOC102120544
uniprot id: A0A2K5UFL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9541:POLR1C
gene id: 9541:POLR1C
uniprot id: A0A2K5WSZ6
uniprot id: A0A7N9DE58
uniprot id: G8F4F6
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9541:GUSB
gene id: 9541:GUSB
uniprot id: A0A2K5WXG5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9541:SPP1
gene id: 9541:SPP1
uniprot id: A0A2K5WL74
uniprot id: G7P5W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9541:TMEM176A
gene id: 9541:TMEM176A
uniprot id: A0A8J8Y9M3
uniprot id: G7P209
names: Similarity
messages: Belongs to the TMEM176 family.

9541:SMPDL3A
gene id: 9541:SMPDL3A
uniprot id: A0A2K5VG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Secreted

9541:MFSD9
gene id: 9541:MFSD9
uniprot id: A0A2K5VXG3
names: Subcellular Location Annotation
messages: Membrane

9541:SLC16A1
gene id: 9541:SLC16A1
uniprot id: A0A8J8XTQ4
uniprot id: G7NW70
uniprot id: I7GN62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9541:PDIA3
gene id: 9541:PDIA3
uniprot id: A0A2K5TWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9541:SLC2A3
gene id: 9541:SLC2A3
uniprot id: A0A2K5VV24
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9541:RPL9
gene id: 9541:RPL9
uniprot id: G7P5F4
uniprot id: Q5IFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:GRAMD1A
gene id: 9541:GRAMD1A
uniprot id: A0A2K5V6W0
uniprot id: A0A2K5V6Z5
uniprot id: G7PX77
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:C19H19orf12
gene id: 9541:C19H19orf12
uniprot id: A0A2K5W4P1
uniprot id: A0A7N9D9S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9541:COQ7
gene id: 9541:COQ7
uniprot id: A0A2K5VUY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9541:KCNH4
gene id: 9541:KCNH4
uniprot id: A0A2K5W8P0
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9541:SNAP91
gene id: 9541:SNAP91
uniprot id: A0A2K5VVQ7
uniprot id: A0A2K5VVV8
uniprot id: A0A2K5VW25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9541:ITK
gene id: 9541:ITK
uniprot id: A0A2K5X9J3
uniprot id: G7P6R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:PAPSS1
gene id: 9541:PAPSS1
uniprot id: A0A2K5V4J6
uniprot id: G7P619
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9541:TMEM120B
gene id: 9541:TMEM120B
uniprot id: A0A2K5WAY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9541:VDAC1
gene id: 9541:VDAC1
uniprot id: I7G2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9541:LOC102125690
gene id: 9541:LOC102125690
uniprot id: A0A2K5VWK1
uniprot id: A0A2K5VWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9541:SLCO4C1
gene id: 9541:SLCO4C1
uniprot id: A0A2K5WSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9541:LOC102117659
gene id: 9541:LOC102117659
uniprot id: A0A2K5VE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:TRMT13
gene id: 9541:TRMT13
uniprot id: A0A8J8Y3H0
uniprot id: G7NV26
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9541:CPT1B
gene id: 9541:CPT1B
uniprot id: A0A2K5UJ22
uniprot id: G7PG77
uniprot id: Q4R7P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:WARS1
gene id: 9541:WARS1
uniprot id: A0A8J8XZ21
uniprot id: G7PBM3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:KAT2A
gene id: 9541:KAT2A
uniprot id: A0A2K5TNE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9541:PLA2G2C
gene id: 9541:PLA2G2C
uniprot id: A0A2K5VRP4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:PTP4A3
gene id: 9541:PTP4A3
uniprot id: A0A8J8YRA9
uniprot id: G7PD16
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9541:GLA
gene id: 9541:GLA
uniprot id: A0A2K5V2Q7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9541:PPP6R3
gene id: 9541:PPP6R3
uniprot id: A0A2K5W7U7
uniprot id: A0A2K5W7W4
uniprot id: A0A2K5W7W6
uniprot id: A0A2K5W865
uniprot id: A0A2K5W872
uniprot id: G7PP54
names: Similarity
messages: Belongs to the SAPS family.

9541:MAGOH
gene id: 9541:MAGOH
uniprot id: A0A8J8XPY4
uniprot id: G7NVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9541:WLS
gene id: 9541:WLS
uniprot id: A0A2K5UNV2
uniprot id: A0A2K5UNY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9541:MAP3K9
gene id: 9541:MAP3K9
uniprot id: A0A2K5U0R9
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9541:GSG1L
gene id: 9541:GSG1L
uniprot id: A0A2K5WEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9541:APEX1
gene id: 9541:APEX1
uniprot id: G8F5P8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9541:KRT4
gene id: 9541:KRT4
uniprot id: A0A2K5U9Q7
names: Similarity
messages: Belongs to the intermediate filament family.

9541:NOP58
gene id: 9541:NOP58
uniprot id: G7PL78
uniprot id: Q4R779
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP5/NOP56 family.
messages: Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1.
messages: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity).
messages: Sumoylation is essential for high-affinity binding to snoRNAs.
messages: nucleolus
messages: nucleoplasm

9541:LOC102117357
gene id: 9541:LOC102117357
uniprot id: G7Q2J7
uniprot id: Q60HE4
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity).
messages: Homodimer; disulfide-linked. Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:NKX6-3
gene id: 9541:NKX6-3
uniprot id: A0A2K5X268
uniprot id: G7PD94
names: Subcellular Location Annotation
messages: Nucleus

9541:CEP43
gene id: 9541:CEP43
uniprot id: A0A2K5X091
uniprot id: A0A2K5X0K7
uniprot id: A0A2K5X0L0
uniprot id: Q4R7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP43 family.
messages: Homodimer. Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts directly with CEP350 and MAPRE1. Interacts with CEP19. Interacts (via N-terminus) with CEP350 (via C-terminus).
messages: Required for anchoring microtubules to the centrosomes. Required for ciliation.
messages: centriole
messages: centrosome
messages: cilium basal body

9541:GSDME
gene id: 9541:GSDME
uniprot id: A0A2K5VUV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9541:LOC102125111
gene id: 9541:LOC102125111
uniprot id: A0A7N9D5L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:SV2B
gene id: 9541:SV2B
uniprot id: A0A2K5U6B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9541:KRT5
gene id: 9541:KRT5
uniprot id: A0A2K5WMJ9
names: Similarity
messages: Belongs to the intermediate filament family.

9541:SPICE1
gene id: 9541:SPICE1
uniprot id: A0A2K5UMY0
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9541:RTCA
gene id: 9541:RTCA
uniprot id: Q4R3J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Monomer.
messages: nucleoplasm

9541:PITRM1
gene id: 9541:PITRM1
uniprot id: A0A2K5W861
names: Subunit
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

9541:ATAD2B
gene id: 9541:ATAD2B
uniprot id: A0A2K5WQJ1
uniprot id: G7PLQ5
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:CORIN
gene id: 9541:CORIN
uniprot id: A0A2K5UDA0
uniprot id: A0A2K5UDA2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ST3GAL1
gene id: 9541:ST3GAL1
uniprot id: A0A2K5VC45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:PPARA
gene id: 9541:PPARA
uniprot id: A0A8J8Y0L9
uniprot id: G7PFY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9541:CTSA
gene id: 9541:CTSA
uniprot id: A0A2K5TQF9
names: Similarity
messages: Belongs to the peptidase S10 family.

9541:MICAL1
gene id: 9541:MICAL1
uniprot id: A0A2K5VYQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9541:POLR2J
gene id: 9541:POLR2J
uniprot id: A0A2K5X258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9541:DCC
gene id: 9541:DCC
uniprot id: A0A2K5V8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9541:SLC6A6
gene id: 9541:SLC6A6
uniprot id: A0A2K5WMS4
uniprot id: A0A2K5WMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9541:E2F1
gene id: 9541:E2F1
uniprot id: A0A2K5W061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:LOC102124022
gene id: 9541:LOC102124022
uniprot id: A0A2K5WY34
uniprot id: G7PXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9541:GTF2H1
gene id: 9541:GTF2H1
uniprot id: A0A2K5V5Z2
uniprot id: A0A2K5V602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9541:SIRT5
gene id: 9541:SIRT5
uniprot id: A0A2K5U3X0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9541:FBXO24
gene id: 9541:FBXO24
uniprot id: Q4R327
names: Function
names: Subunit
messages: Directly interacts with SKP1 and CUL1.
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9541:XRCC4
gene id: 9541:XRCC4
uniprot id: Q4R3G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9541:SLC25A35
gene id: 9541:SLC25A35
uniprot id: A0A2K5VM58
uniprot id: A0A7N9CM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:NME9
gene id: 9541:NME9
uniprot id: A0A2K5V278
uniprot id: A0A8J8XRC5
uniprot id: G7P034
names: Similarity
messages: Belongs to the NDK family.

9541:ATP6V1G1
gene id: 9541:ATP6V1G1
uniprot id: A0A2K5TSA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:KHDC4
gene id: 9541:KHDC4
uniprot id: A0A8J8XYR8
uniprot id: G7NV70
names: Similarity
messages: Belongs to the KHDC4 family.

9541:PARP2
gene id: 9541:PARP2
uniprot id: A0A2K5UFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9541:DDX59
gene id: 9541:DDX59
uniprot id: A0A2K5U4U4
uniprot id: A0A2K5U4W3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9541:PPME1
gene id: 9541:PPME1
uniprot id: A0A2K5UXG5
uniprot id: I7GKE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9541:CDH3
gene id: 9541:CDH3
uniprot id: A0A2K5WPM3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:GUK1
gene id: 9541:GUK1
uniprot id: A0A2K5WYD7
uniprot id: A0A2K5WYM4
names: Similarity
messages: Belongs to the guanylate kinase family.

9541:RPL31
gene id: 9541:RPL31
uniprot id: A0A8J8YQZ0
uniprot id: G7NZE1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9541:PMPCA
gene id: 9541:PMPCA
uniprot id: A0A2K5TWC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9541:CRLS1
gene id: 9541:CRLS1
uniprot id: A0A2K5V1X4
uniprot id: Q4R7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9541:FGB
gene id: 9541:FGB
uniprot id: A0A8J8XQ55
uniprot id: G7P6F7
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9541:AFG3L2
gene id: 9541:AFG3L2
uniprot id: A0A2K5VEI6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9541:CUL4A
gene id: 9541:CUL4A
uniprot id: A0A2K5VIT2
uniprot id: A0A2K5VIU5
names: Similarity
messages: Belongs to the cullin family.

9541:LOC102136134
gene id: 9541:LOC102136134
uniprot id: A0A2K5U5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:MS4A14
gene id: 9541:MS4A14
uniprot id: A0A2K5X5E8
names: Similarity
messages: Belongs to the MS4A family.

9541:NCR3
gene id: 9541:NCR3
uniprot id: G7P4P5
uniprot id: P61483
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

9541:JPT2
gene id: 9541:JPT2
uniprot id: A0A2K5TKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9541:SERPINA5
gene id: 9541:SERPINA5
uniprot id: A0A2K5WKL7
names: Similarity
messages: Belongs to the serpin family.

9541:AP4M1
gene id: 9541:AP4M1
uniprot id: A0A2K5U641
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9541:NDUFB2
gene id: 9541:NDUFB2
uniprot id: A0A7N9CLV3
uniprot id: I7GKV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:VEGFC
gene id: 9541:VEGFC
uniprot id: A0A2K5WBI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9541:NELL2
gene id: 9541:NELL2
uniprot id: A0A2K5X1B5
uniprot id: G7PHM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PDP2
gene id: 9541:PDP2
uniprot id: A0A8J8YJS8
uniprot id: G7Q1C0
names: Similarity
messages: Belongs to the PP2C family.

9541:SPAM1
gene id: 9541:SPAM1
uniprot id: A0A2K5U3E3
uniprot id: Q4R6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9541:HSD17B6
gene id: 9541:HSD17B6
uniprot id: A0A2K5WZT4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:ITGAM
gene id: 9541:ITGAM
uniprot id: A0A2K5UU26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:LOC102142852
gene id: 9541:LOC102142852
uniprot id: A0A2K5WFS0
names: Similarity
messages: Belongs to the GAGE family.

9541:GBF1
gene id: 9541:GBF1
uniprot id: A0A2K5W603
uniprot id: G7PDU4
names: Subcellular Location Annotation
messages: Golgi apparatus

9541:LCK
gene id: 9541:LCK
uniprot id: A0A2K5UWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9541:ACTG2
gene id: 9541:ACTG2
uniprot id: A0A8J8XMV4
uniprot id: G7PMI2
names: Similarity
messages: Belongs to the actin family.

9541:ACD
gene id: 9541:ACD
uniprot id: A0A2K5WKE0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9541:MID1
gene id: 9541:MID1
uniprot id: A0A8J8YI77
uniprot id: G7Q274
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: Nucleus
messages: cytoskeleton

9541:PWP2
gene id: 9541:PWP2
uniprot id: A0A2K5VMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9541:ADD2
gene id: 9541:ADD2
uniprot id: A0A2K5WJN0
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9541:LOC102132587
gene id: 9541:LOC102132587
uniprot id: A0A2K5WCI0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:ATP6V1A
gene id: 9541:ATP6V1A
uniprot id: A0A2K5TMW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9541:C2H3orf70
gene id: 9541:C2H3orf70
uniprot id: A0A7N9D6P6
names: Similarity
messages: Belongs to the UPF0524 family.

9541:ATG4D
gene id: 9541:ATG4D
uniprot id: A0A2K5U2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9541:EIF3K
gene id: 9541:EIF3K
uniprot id: A0A2K5X240
uniprot id: G8F5R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9541:LINGO1
gene id: 9541:LINGO1
uniprot id: Q9N008
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
messages: Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity). Interacts with NGRF, RTN4R and MYT1L (By similarity).
messages: N-glycosylated. Contains predominantly high-mannose glycans (By similarity).
messages: The intracellular domain of LINGO1 interacts with MYT1L.

9541:C3
gene id: 9541:C3
uniprot id: A0A2K5VPN1
names: Function
names: Subcellular Location Annotation
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9541:GPR50
gene id: 9541:GPR50
uniprot id: A0A2K5WGA7
uniprot id: G7Q1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102118065
gene id: 9541:LOC102118065
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:ILVBL
gene id: 9541:ILVBL
uniprot id: A0A2K5USE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9541:FGF20
gene id: 9541:FGF20
uniprot id: A0A2K5VCR8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:PSMA4
gene id: 9541:PSMA4
uniprot id: Q4R932
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9541:ADGRD1
gene id: 9541:ADGRD1
uniprot id: A0A2K5UX44
uniprot id: A0A2K5UX70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:TMED3
gene id: 9541:TMED3
uniprot id: A0A2K5WIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9541:AP1S2
gene id: 9541:AP1S2
uniprot id: A0A2K5TTY7
uniprot id: A0A2K5TU05
uniprot id: A0A7N9DB11
uniprot id: A0A8J8XS11
uniprot id: G7Q2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9541:ACYP1
gene id: 9541:ACYP1
uniprot id: A0A2K5USW4
names: Similarity
messages: Belongs to the acylphosphatase family.

9541:GNGT2
gene id: 9541:GNGT2
uniprot id: A0A2K5U966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:ERBIN
gene id: 9541:ERBIN
uniprot id: A0A2K5V407
uniprot id: A0A2K5V423
uniprot id: A0A2K5V490
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9541:FAR1
gene id: 9541:FAR1
uniprot id: A0A2K5V668
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9541:SNTG2
gene id: 9541:SNTG2
uniprot id: A0A2K5WEQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9541:GFOD1
gene id: 9541:GFOD1
uniprot id: A0A8J8XSS3
uniprot id: G7P4F9
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9541:P2RY4
gene id: 9541:P2RY4
uniprot id: A0A2K5UD43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ATP7A
gene id: 9541:ATP7A
uniprot id: A0A2K5X0T9
uniprot id: A0A2K5X0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9541:HRH4
gene id: 9541:HRH4
uniprot id: Q3V8G8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:LRRC7
gene id: 9541:LRRC7
uniprot id: A0A2K5UWW0
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9541:LHFPL1
gene id: 9541:LHFPL1
uniprot id: A0A2K5W8R0
uniprot id: A0A2K5W8R3
uniprot id: G7Q3H7
names: Subcellular Location Annotation
messages: Membrane

9541:MANEAL
gene id: 9541:MANEAL
uniprot id: A0A2K5W9M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:ENTPD3
gene id: 9541:ENTPD3
uniprot id: A0A2K5VC94
uniprot id: A0A2K5VCB1
uniprot id: G7NYI6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:FAIM2
gene id: 9541:FAIM2
uniprot id: A0A2K5VJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9541:HACD3
gene id: 9541:HACD3
uniprot id: I7GJV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ITGB4
gene id: 9541:ITGB4
uniprot id: A0A2K5TWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9541:SERPINB1
gene id: 9541:SERPINB1
uniprot id: A0A2K5TTD0
uniprot id: G7P4B6
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9541:GPR37
gene id: 9541:GPR37
uniprot id: A0A2K5WL99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:HNRNPU
gene id: 9541:HNRNPU
uniprot id: A0A2K5TPK4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102145097
gene id: 9541:LOC102145097
uniprot id: A0A2K5UK91
names: Subcellular Location Annotation
messages: Membrane

9541:ARL1
gene id: 9541:ARL1
uniprot id: A0A7N9CXT6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:RPLP2
gene id: 9541:RPLP2
uniprot id: I7GJM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9541:SLITRK4
gene id: 9541:SLITRK4
uniprot id: A0A2K5UMT4
names: Similarity
messages: Belongs to the SLITRK family.

9541:HOATZ
gene id: 9541:HOATZ
uniprot id: A0A2K5W2W6
names: Similarity
messages: Belongs to the HOATZ family.

9541:NXF3
gene id: 9541:NXF3
uniprot id: A0A2K5VUK3
uniprot id: A0A2K5VUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9541:CHRM4
gene id: 9541:CHRM4
uniprot id: A0A8J8XC81
uniprot id: G7PQB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9541:SST
gene id: 9541:SST
uniprot id: A0A8J8Y0N9
uniprot id: G7NYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9541:C11H12orf57
gene id: 9541:C11H12orf57
uniprot id: A0A7N9IC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9541:IDE
gene id: 9541:IDE
uniprot id: A0A2K5TUC3
uniprot id: A0A2K5TUD2
names: Similarity
messages: Belongs to the peptidase M16 family.

9541:VAMP3
gene id: 9541:VAMP3
uniprot id: Q25MJ3
uniprot id: Q4R8T0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Early endosome membrane
messages: Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with PICALM (By similarity).
messages: Membrane
messages: Recycling endosome membrane
messages: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
messages: Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.
messages: synaptosome

9541:LOC102134374
gene id: 9541:LOC102134374
uniprot id: G7P6T4
uniprot id: Q4R6P8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
messages: Membrane

9541:LOC102130507
gene id: 9541:LOC102130507
uniprot id: Q4R4F8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMN family.
messages: Cajal body
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Homooligomer; may form higher order homooligomers in the dimer to octamer range. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259. Interacts with DDX20, FBL, NOLA1, RNUT1, SYNCRIP and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3. Interacts with GEMIN2; the interaction is direct. Interacts with GEMIN3; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB; the interaction is direct. Interacts (via Tudor domain) with SNRPD1 (via C-terminus); the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7. Interacts (via C-terminal region) with ZPR1 (via C-terminal region). Interacts (via Tudor domain) with COIL. Interacts with SETX; recruits SETX to POLR2A. Interacts with POLR2A (via the C-terminal domain (CTD)). Interacts with PRMT5. Interacts with XRN2. Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner. Interacts (via Tudor domain) with SF3B2 ('Arg-508'-methylated form). Interacts with WRAP53/TCAB1. Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules. Interacts with FRG1.
messages: Perikaryon
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
messages: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
messages: Z line
messages: axon
messages: gem
messages: neuron projection

9541:CHST2
gene id: 9541:CHST2
uniprot id: A0A2K5UN89
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:BAIAP2
gene id: 9541:BAIAP2
uniprot id: Q4R507
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9541:TMOD2
gene id: 9541:TMOD2
uniprot id: A0A2K5VSA0
uniprot id: G7PBH3
uniprot id: Q2PFU3
names: Subcellular Location Annotation
messages: cytoskeleton

9541:PHACTR1
gene id: 9541:PHACTR1
uniprot id: A0A2K5WXZ5
uniprot id: A0A2K5WYA5
uniprot id: A0A7N9D260
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

9541:SH3YL1
gene id: 9541:SH3YL1
uniprot id: A0A2K5TSM9
uniprot id: A0A2K5TSP2
uniprot id: A0A2K5TSQ3
uniprot id: A0A7N9D3Y5
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9541:ATP6AP2
gene id: 9541:ATP6AP2
uniprot id: Q4R500
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9541:LPAR4
gene id: 9541:LPAR4
uniprot id: G7Q339
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CD93
gene id: 9541:CD93
uniprot id: A0A2K5VH53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ZNF512
gene id: 9541:ZNF512
uniprot id: Q95JV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:PPP4R3B
gene id: 9541:PPP4R3B
uniprot id: A0A2K5WJD8
uniprot id: A0A2K5WJE9
uniprot id: A0A2K5WJI2
uniprot id: A0A8J8XJ84
uniprot id: G7PM87
names: Similarity
messages: Belongs to the SMEK family.

9541:CLDN10
gene id: 9541:CLDN10
uniprot id: A0A2K5UHD3
uniprot id: A0A2K5UHD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:CD37
gene id: 9541:CD37
uniprot id: A0A2K5V5D2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:HSD11B1L
gene id: 9541:HSD11B1L
uniprot id: Q6Q7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

9541:EVA1C
gene id: 9541:EVA1C
uniprot id: A0A2K5U5X6
names: Similarity
messages: Belongs to the EVA1 family.

9541:MGRN1
gene id: 9541:MGRN1
uniprot id: A0A2K5UVG8
uniprot id: A0A2K5UVH2
uniprot id: A0A2K5UVI5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9541:LOC102125581
gene id: 9541:LOC102125581
uniprot id: G7P1K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:TBL1X
gene id: 9541:TBL1X
uniprot id: Q4R8H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat EBI family.
messages: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
messages: Homotetramer; dimer of dimers. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with GPS2 (when sumoylated); leading to protect GPS2 against degradation by the proteasome. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X (By similarity). Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4. Interacts with MECP2; recruits TBL1X to the heterochromatin foci (By similarity).
messages: Nucleus

9541:TRMT2B
gene id: 9541:TRMT2B
uniprot id: A0A2K5VUK1
uniprot id: A0A2K5VUK7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MED13
gene id: 9541:MED13
uniprot id: A0A2K5UFV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:DDC
gene id: 9541:DDC
uniprot id: A0A2K5ULX8
uniprot id: A2V9Y9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9541:LHX6
gene id: 9541:LHX6
uniprot id: A0A2K5VM37
uniprot id: A0A2K5VM87
uniprot id: A0A2K5VMB9
uniprot id: A0A2K5VMC6
names: Subcellular Location Annotation
messages: Nucleus

9541:FANCM
gene id: 9541:FANCM
uniprot id: A0A2K5X791
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9541:ELK3
gene id: 9541:ELK3
uniprot id: A0A8J8YAT6
uniprot id: G7PJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:TUBA1C
gene id: 9541:TUBA1C
uniprot id: A0A805QYG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9541:C15H9orf64
gene id: 9541:C15H9orf64
uniprot id: A0A2K5WUN8
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9541:MBTPS1
gene id: 9541:MBTPS1
uniprot id: A0A2K5V1G2
names: Similarity
messages: Belongs to the peptidase S8 family.

9541:LIPN
gene id: 9541:LIPN
uniprot id: A0A8J8Y3P4
uniprot id: G7PDH4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:GRIN2B
gene id: 9541:GRIN2B
uniprot id: A0A8J8YJG1
uniprot id: G7PJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:SEMA3D
gene id: 9541:SEMA3D
uniprot id: A0A2K5VQE5
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SPRR3
gene id: 9541:SPRR3
uniprot id: A0A7N9C8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9541:MED18
gene id: 9541:MED18
uniprot id: A0A2K5WHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:VPS53
gene id: 9541:VPS53
uniprot id: A0A2K5U0U7
uniprot id: A0A2K5U0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:NME5
gene id: 9541:NME5
uniprot id: A0A2K5WL60
names: Similarity
messages: Belongs to the NDK family.

9541:AHCYL2
gene id: 9541:AHCYL2
uniprot id: A0A2K5X5H4
uniprot id: A0A2K5X5Z0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9541:MTO1
gene id: 9541:MTO1
uniprot id: Q4R4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
messages: Mitochondrion

9541:KCNN4
gene id: 9541:KCNN4
uniprot id: A0A2K5WM04
names: Subcellular Location Annotation
messages: Membrane

9541:OPN1SW
gene id: 9541:OPN1SW
uniprot id: Q9XS34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9541:SLC47A1
gene id: 9541:SLC47A1
uniprot id: A0A0R8GG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9541:RPS28
gene id: 9541:RPS28
uniprot id: A0A2K5W098
uniprot id: G8F4P1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

9541:SLC16A2
gene id: 9541:SLC16A2
uniprot id: A0A2K5TN74
names: Subcellular Location Annotation
messages: Membrane

9541:ASB18
gene id: 9541:ASB18
uniprot id: A0A2K5VCK7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:AOX1
gene id: 9541:AOX1
uniprot id: Q5FB27
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: Cytoplasm
messages: Detected at high levels in liver, also detected in lung, kidney, lacrimal gland and olfactory mucosa.
messages: Homodimer.
messages: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis (By similarity).

9541:SUGP1
gene id: 9541:SUGP1
uniprot id: A0A2K5UUB1
names: Subcellular Location Annotation
messages: Nucleus

9541:NUP93
gene id: 9541:NUP93
uniprot id: A0A2K5W1A6
uniprot id: G7Q166
uniprot id: Q4R8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9541:KRT72
gene id: 9541:KRT72
uniprot id: A0A2K5W5G3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:DOCK3
gene id: 9541:DOCK3
uniprot id: A0A2K5TJ63
names: Similarity
messages: Belongs to the DOCK family.

9541:DNM2
gene id: 9541:DNM2
uniprot id: A0A2K5WRV6
uniprot id: A0A2K5WRZ9
uniprot id: A0A2K5WS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9541:LOC102121548
gene id: 9541:LOC102121548
uniprot id: A0A2K5TQ29
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9541:LCAT
gene id: 9541:LCAT
uniprot id: A0A2K5WDQ7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:ADAMTS5
gene id: 9541:ADAMTS5
uniprot id: A0A2K5X879
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:PTGFR
gene id: 9541:PTGFR
uniprot id: A0A7N9D088
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TENT5D
gene id: 9541:TENT5D
uniprot id: A0A7N9DC55
uniprot id: G8F374
names: Similarity
messages: Belongs to the TENT family.

9541:LIN28A
gene id: 9541:LIN28A
uniprot id: A0A7N9IH37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9541:BTD
gene id: 9541:BTD
uniprot id: A0A2K5UBN7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9541:CCL18
gene id: 9541:CCL18
uniprot id: A0A2K5TKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:GJB1
gene id: 9541:GJB1
uniprot id: A0A7N9CAQ4
uniprot id: G8F3U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:CDC14A
gene id: 9541:CDC14A
uniprot id: A0A2K5X9F1
uniprot id: A0A2K5X9G4
uniprot id: A0A2K5X9H4
uniprot id: G7NV31
uniprot id: Q4R5R2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9541:BRD1
gene id: 9541:BRD1
uniprot id: A0A2K5UQM2
uniprot id: A0A2K5UQN1
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102124950
gene id: 9541:LOC102124950
uniprot id: A0A2K5UKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ARSH
gene id: 9541:ARSH
uniprot id: A0A8J8XL05
uniprot id: G7Q249
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:METAP1
gene id: 9541:METAP1
uniprot id: A0A2K5VW41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9541:ARHGAP26
gene id: 9541:ARHGAP26
uniprot id: A0A2K5TXJ4
uniprot id: A0A7N9CJZ9
uniprot id: A0A7N9IDB1
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9541:LOC102123927
gene id: 9541:LOC102123927
uniprot id: A0A2K5VAA9
names: Similarity
messages: Belongs to the SPAN-X family.

9541:INSIG2
gene id: 9541:INSIG2
uniprot id: A0A2K5V608
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9541:SPINK2
gene id: 9541:SPINK2
uniprot id: P34953
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (By similarity). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin (By similarity).
messages: More abundant in epididymis than in testis.
messages: Secreted
messages: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin (By similarity).
messages: acrosome

9541:LOC102147033
gene id: 9541:LOC102147033
uniprot id: A0A7N9CD12
uniprot id: G7PJL0
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

9541:KEG98 p04
gene id: 9541:KEG98_p04
uniprot id: C3W4Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9541:ERC1
gene id: 9541:ERC1
uniprot id: A0A2K5V8C8
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ANO10
gene id: 9541:ANO10
uniprot id: A0A2K5VZC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:RPA2
gene id: 9541:RPA2
uniprot id: A0A2K5UIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9541:CCDC90B
gene id: 9541:CCDC90B
uniprot id: A0A2K5WFP1
uniprot id: A0A2K5WFQ9
names: Similarity
messages: Belongs to the CCDC90 family.

9541:LDHD
gene id: 9541:LDHD
uniprot id: A0A2K5UML6
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9541:ADAM17
gene id: 9541:ADAM17
uniprot id: A0A2K5X241
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CORO2B
gene id: 9541:CORO2B
uniprot id: A0A2K5USB3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9541:SI
gene id: 9541:SI
uniprot id: A0A2K5U6U6
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102134776
gene id: 9541:LOC102134776
uniprot id: A0A2K5UP92
names: Similarity
messages: Belongs to the cytochrome b5 family.

9541:NUDT5
gene id: 9541:NUDT5
uniprot id: A0A2K5TKA0
uniprot id: A0A7N9CQS9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9541:PHOSPHO1
gene id: 9541:PHOSPHO1
uniprot id: A0A2K5V191
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9541:RASGRP2
gene id: 9541:RASGRP2
uniprot id: A0A7N9CIC2
names: Similarity
messages: Belongs to the RASGRP family.

9541:LIPC
gene id: 9541:LIPC
uniprot id: A0A2K5VV98
uniprot id: A0A2K5VVL1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:CUL9
gene id: 9541:CUL9
uniprot id: A0A2K5TWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9541:ABLIM1
gene id: 9541:ABLIM1
uniprot id: A0A2K5WTD1
uniprot id: A0A2K5WTM8
names: Subcellular Location Annotation
messages: Cytoplasm

9541:TRPC1
gene id: 9541:TRPC1
uniprot id: A0A2K5U8P8
uniprot id: G7P008
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9541:GATA1
gene id: 9541:GATA1
uniprot id: A0A2K5UYX7
uniprot id: G7Q2N4
names: Subcellular Location Annotation
messages: Nucleus

9541:ABHD1
gene id: 9541:ABHD1
uniprot id: A0A2K5WW48
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9541:ENKD1
gene id: 9541:ENKD1
uniprot id: A0A2K5UVS6
names: Subcellular Location Annotation
messages: cilium axoneme

9541:MAEA
gene id: 9541:MAEA
uniprot id: A0A2K5U833
uniprot id: A0A2K5U889
uniprot id: A0A2K5U8C1
names: Subcellular Location Annotation
messages: Nucleus matrix
messages: nucleoplasm

9541:KPNA7
gene id: 9541:KPNA7
uniprot id: A0A2K5UXA0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:ALOX5
gene id: 9541:ALOX5
uniprot id: A0A2K5UID9
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:HMGCS2
gene id: 9541:HMGCS2
uniprot id: A0A2K5VHJ3
uniprot id: G7NX69
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9541:SCARB1
gene id: 9541:SCARB1
uniprot id: A0A2K5X784
uniprot id: A0A2K5X789
names: Similarity
messages: Belongs to the CD36 family.

9541:OPTN
gene id: 9541:OPTN
uniprot id: A0A2K5VUU9
uniprot id: Q95KA2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
messages: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
messages: Recycling endosome
messages: Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9541:USP33
gene id: 9541:USP33
uniprot id: A0A2K5WSA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9541:ABHD16A
gene id: 9541:ABHD16A
uniprot id: A0A7N9C8M1
uniprot id: A0A7N9D0E7
uniprot id: Q4R8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane
messages: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity).

9541:KEG98 p06
gene id: 9541:KEG98_p06
uniprot id: C3W4Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

9541:AGPAT1
gene id: 9541:AGPAT1
uniprot id: A0A8J8YED8
uniprot id: G7P2Q6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9541:FOXP1
gene id: 9541:FOXP1
uniprot id: A0A2K5X233
names: Subcellular Location Annotation
messages: Nucleus

9541:JPH3
gene id: 9541:JPH3
uniprot id: A0A2K5VYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9541:PGD
gene id: 9541:PGD
uniprot id: A0A2K5WBE9
uniprot id: I7G9P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9541:TRMT112
gene id: 9541:TRMT112
uniprot id: A0A2K5VLA0
names: Similarity
messages: Belongs to the TRM112 family.

9541:CENPQ
gene id: 9541:CENPQ
uniprot id: Q4R7G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-Q/OKP1 family.
messages: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
messages: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
messages: Nucleus
messages: centromere

9541:DPY19L1
gene id: 9541:DPY19L1
uniprot id: A0A2K5WU47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9541:PPP1R10
gene id: 9541:PPP1R10
uniprot id: A0A8J8XGH1
uniprot id: G7P4L7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9541:PGF
gene id: 9541:PGF
uniprot id: A0A2K5VMQ8
uniprot id: A0A2K5VMT8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9541:PIGO
gene id: 9541:PIGO
uniprot id: A0A2K5W6E8
uniprot id: G7PS15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:FUT10
gene id: 9541:FUT10
uniprot id: A0A2K5UAV0
uniprot id: A0A2K5UAV7
uniprot id: A0A2K5UAX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9541:ATPSCKMT
gene id: 9541:ATPSCKMT
uniprot id: I7GAZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9541:CPNE3
gene id: 9541:CPNE3
uniprot id: A0A2K5UVS8
names: Similarity
messages: Belongs to the copine family.

9541:ALDH1A1
gene id: 9541:ALDH1A1
uniprot id: Q4R5G3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:PKM
gene id: 9541:PKM
uniprot id: A0A2K5VNC3
uniprot id: A0A2K5VNF3
uniprot id: I7GH00
names: Similarity
messages: Belongs to the pyruvate kinase family.

9541:ADAMTS15
gene id: 9541:ADAMTS15
uniprot id: A0A2K5UEC5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:CER1
gene id: 9541:CER1
uniprot id: A0A2K5WJN9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ETFRF1
gene id: 9541:ETFRF1
uniprot id: A0A2K5X1B3
names: Similarity
messages: Belongs to the complex I LYR family.

9541:CPNE7
gene id: 9541:CPNE7
uniprot id: A0A2K5WKL1
names: Similarity
messages: Belongs to the copine family.

9541:CDC42SE1
gene id: 9541:CDC42SE1
uniprot id: A0A2K5TSF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9541:LIPT2
gene id: 9541:LIPT2
uniprot id: A0A2K5WLX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9541:NOX1
gene id: 9541:NOX1
uniprot id: A0A2K5VF08
uniprot id: A0A8J8XXT4
uniprot id: G7Q381
names: Subcellular Location Annotation
messages: Membrane

9541:CSH4
gene id: 9541:CSH4
uniprot id: A0A2K5WEV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9541:CENPN
gene id: 9541:CENPN
uniprot id: A0A8J8XL27
uniprot id: G7PZT4
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9541:AGBL5
gene id: 9541:AGBL5
uniprot id: A0A2K5X8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9541:SPG21
gene id: 9541:SPG21
uniprot id: A0A2K5WGW4
uniprot id: G8F5Q6
uniprot id: Q4R5H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Cytoplasm
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9541:KRT12
gene id: 9541:KRT12
uniprot id: A0A8J8XZW2
uniprot id: G7PUQ0
names: Similarity
messages: Belongs to the intermediate filament family.

9541:SLCO1B3
gene id: 9541:SLCO1B3
uniprot id: L7TAY6
uniprot id: Q5S2D3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC101865451
gene id: 9541:LOC101865451
uniprot id: Q4R7F9
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:NXT1
gene id: 9541:NXT1
uniprot id: A0A2K5UHH8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9541:MCTP1
gene id: 9541:MCTP1
uniprot id: A0A2K5X4T4
uniprot id: A0A2K5X4Y1
uniprot id: A0A2K5X595
names: Subcellular Location Annotation
messages: Membrane

9541:MYO9A
gene id: 9541:MYO9A
uniprot id: A0A2K5UK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

9541:ZBED1
gene id: 9541:ZBED1
uniprot id: A0A2K5UJD3
names: Subcellular Location Annotation
messages: Nucleus

9541:CDC42
gene id: 9541:CDC42
uniprot id: Q4R4R6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with DOCK11/Zizimin2; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK9; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK8 (via DHR-2 domain); the interaction activates CDC42 by exchanging GDP for GTP. Interacts with IQGAP1. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1. Interacts with USP6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. Interacts with ARHGDIB; this maintains CDC42 in the inactive, GDP-bound form. Interacts in (GTP-bound form) with FNBP1L and ABI1, but only in the presence of FNBP1L.
messages: Midbody
messages: Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: centrosome
messages: lamellipodium membrane
messages: spindle

9541:RAB3IL1
gene id: 9541:RAB3IL1
uniprot id: A0A2K5VUQ3
names: Similarity
messages: Belongs to the SEC2 family.

9541:APPL2
gene id: 9541:APPL2
uniprot id: A0A2K5VI64
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9541:ABL2
gene id: 9541:ABL2
uniprot id: A0A2K5TT41
uniprot id: A0A2K5TT62
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:GPRC6A
gene id: 9541:GPRC6A
uniprot id: A0A2K5WIY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:KAT7
gene id: 9541:KAT7
uniprot id: A0A2K5TSE2
uniprot id: A0A2K5TSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9541:HNRNPC
gene id: 9541:HNRNPC
uniprot id: A0A2K5U148
uniprot id: I7GH07
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9541:ABCG5
gene id: 9541:ABCG5
uniprot id: A0A2K5WA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9541:LOC101866756
gene id: 9541:LOC101866756
uniprot id: A0A2K5VE04
uniprot id: A0A2K5VE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9541:PDE1B
gene id: 9541:PDE1B
uniprot id: A0A2K5V7J5
uniprot id: G7PHX1
uniprot id: Q9BE16
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:ST3GAL5
gene id: 9541:ST3GAL5
uniprot id: A0A2K5VGK2
uniprot id: A0A2K5VGK8
uniprot id: A0A2K5VGM4
uniprot id: A0A7N9D559
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:POLE2
gene id: 9541:POLE2
uniprot id: A0A2K5U0N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9541:LOC102130413
gene id: 9541:LOC102130413
uniprot id: A0A2K5UFX5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:STON2
gene id: 9541:STON2
uniprot id: A0A2K5X4K2
uniprot id: A0A2K5X546
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9541:GRPR
gene id: 9541:GRPR
uniprot id: A0A2K5U3F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:DMAP1
gene id: 9541:DMAP1
uniprot id: G7NUY3
uniprot id: Q2PFQ0
names: Subcellular Location Annotation
messages: Nucleus

9541:UNC13C
gene id: 9541:UNC13C
uniprot id: A0A2K5W7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

9541:LOC102138312
gene id: 9541:LOC102138312
uniprot id: A0A8J8XBQ0
uniprot id: G7PRZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9541:FBLN5
gene id: 9541:FBLN5
uniprot id: A0A2K5VLE1
uniprot id: A0A2K5VLH4
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CREB3L3
gene id: 9541:CREB3L3
uniprot id: A0A2K5WZZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102125550
gene id: 9541:LOC102125550
uniprot id: A0A2K5UEA5
names: Similarity
messages: Belongs to the NDK family.

9541:TMEM33
gene id: 9541:TMEM33
uniprot id: A0A8J8XUW8
uniprot id: G7P5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9541:AGPAT5
gene id: 9541:AGPAT5
uniprot id: A0A2K5TMB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:UPF3B
gene id: 9541:UPF3B
uniprot id: A0A2K5VTM2
uniprot id: A0A2K5VTM6
names: Similarity
messages: Belongs to the RENT3 family.

9541:SUCLG2
gene id: 9541:SUCLG2
uniprot id: A0A2K5WWV2
uniprot id: A0A2K5WX63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9541:PIGF
gene id: 9541:PIGF
uniprot id: A0A2K5VGY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:DIMT1
gene id: 9541:DIMT1
uniprot id: Q95KJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.
messages: nucleolus
messages: nucleoplasm

9541:OXCT1
gene id: 9541:OXCT1
uniprot id: A0A2K5WEA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9541:FYN
gene id: 9541:FYN
uniprot id: A0A2K5TKJ7
uniprot id: A0A2K5TKN9
uniprot id: A0A8J8XEI0
uniprot id: G7P3M8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:NUP85
gene id: 9541:NUP85
uniprot id: I7GE27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9541:PFKFB1
gene id: 9541:PFKFB1
uniprot id: A0A2K5V950
uniprot id: G7Q2U3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9541:ORMDL1
gene id: 9541:ORMDL1
uniprot id: G7PL13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9541:CRABP1
gene id: 9541:CRABP1
uniprot id: A0A7N9D888
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

9541:WDR49
gene id: 9541:WDR49
uniprot id: A0A2K5V151
names: Similarity
messages: Belongs to the serpin family.

9541:MPHOSPH10
gene id: 9541:MPHOSPH10
uniprot id: A0A2K5X3Z0
uniprot id: A0A7N9CX54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9541:NHSL1
gene id: 9541:NHSL1
uniprot id: A0A2K5WFT2
names: Similarity
messages: Belongs to the NHS family.

9541:PHF5A
gene id: 9541:PHF5A
uniprot id: A0A8J8Y2R2
uniprot id: G7PFN3
names: Similarity
messages: Belongs to the PHF5 family.

9541:RTP1
gene id: 9541:RTP1
uniprot id: Q95JK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM7 family.
messages: Cell membrane
messages: Interacts with olfactory receptors.
messages: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

9541:GYS2
gene id: 9541:GYS2
uniprot id: A0A2K5TYV6
uniprot id: A0A2K5TYW9
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9541:EFTUD2
gene id: 9541:EFTUD2
uniprot id: A0A2K5W206
uniprot id: G7PV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9541:CYP4X1
gene id: 9541:CYP4X1
uniprot id: A0A2K5X8R7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:GDPD5
gene id: 9541:GDPD5
uniprot id: A0A2K5VDT2
uniprot id: A0A8J8YKA5
uniprot id: G7PN97
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:RAB5A
gene id: 9541:RAB5A
uniprot id: P61271
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Early endosome membrane
messages: Endosome membrane
messages: Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with PIK3CB. Interacts with EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with RINL. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RABEP1; one RABEP1 homodimer binds two RAB5A chains, but at opposite sides of the dimer. Interacts with OCRL and INPP5F. May be a component of a complex composed of RAB5A, DYN2 and PIK3C3. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5. Interacts with APPL2 (By similarity). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).
messages: Melanosome
messages: Membrane
messages: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
messages: cytosol
messages: phagosome membrane
messages: ruffle

9541:LOC102146042
gene id: 9541:LOC102146042
uniprot id: A0A023JBX1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9541:RARS2
gene id: 9541:RARS2
uniprot id: A0A8J8YQB1
uniprot id: G7P3K3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:LAMB4
gene id: 9541:LAMB4
uniprot id: A0A2K5W8H4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9541:PYGB
gene id: 9541:PYGB
uniprot id: A0A2K5TPE2
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9541:UFL1
gene id: 9541:UFL1
uniprot id: Q4R367
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFL1 family.
messages: Chromosome
messages: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (By similarity). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition. Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4. Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis. Required for cardiac homeostasis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Interacts with DDRGK1 (via PCI domain). Interacts with UFC1. Interacts with RELA. Interacts with TRIP4. Interacts with CDK5RAP3; the interaction is direct. Interacts with NBN; promoting recruitment to double-strand breaks following DNA damage.
messages: Nucleus
messages: Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome.
messages: cytosol

9541:GABRA5
gene id: 9541:GABRA5
uniprot id: A0A2K5UB56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:FCGRT
gene id: 9541:FCGRT
uniprot id: Q8SPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
messages: Endosome membrane
messages: FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (By similarity).

9541:LOC102123539
gene id: 9541:LOC102123539
uniprot id: A0A8J8YJQ8
uniprot id: G7P2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9541:STK39
gene id: 9541:STK39
uniprot id: A0A2K5UYV4
uniprot id: A0A7N9DEN5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9541:PYGM
gene id: 9541:PYGM
uniprot id: Q8HXW4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation.
messages: Belongs to the glycogen phosphorylase family.
messages: Homodimer. Homotetramer; to form the enzymatically active phosphorylase A.
messages: Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

9541:MASP2
gene id: 9541:MASP2
uniprot id: A0A2K5UJY0
uniprot id: A0A2K5UK03
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PARP8
gene id: 9541:PARP8
uniprot id: A0A2K5W8E2
uniprot id: A0A2K5W8K0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:EXTL2
gene id: 9541:EXTL2
uniprot id: A0A2K5U7X5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ERGIC1
gene id: 9541:ERGIC1
uniprot id: A0A2K5WJ67
uniprot id: A0A2K5WJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9541:ACTRT1
gene id: 9541:ACTRT1
uniprot id: Q4R821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Cytoplasm
messages: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
messages: Nucleus
messages: cytoskeleton

9541:KCNH3
gene id: 9541:KCNH3
uniprot id: A0A2K5VRR6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9541:LIX1L
gene id: 9541:LIX1L
uniprot id: A0A2K5UXZ2
names: Similarity
messages: Belongs to the LIX1 family.

9541:PPDPFL
gene id: 9541:PPDPFL
uniprot id: A0A2K5VPQ9
names: Similarity
messages: Belongs to the PPDPF family.

9541:MRS2
gene id: 9541:MRS2
uniprot id: A0A2K5WKP9
uniprot id: A0A2K5WKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9541:CCN6
gene id: 9541:CCN6
uniprot id: A0A2K5WL19
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:EPS8L2
gene id: 9541:EPS8L2
uniprot id: A0A2K5VHT1
names: Similarity
messages: Belongs to the EPS8 family.

9541:CDH1
gene id: 9541:CDH1
uniprot id: A0A2K5V299
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9541:ADAMTS14
gene id: 9541:ADAMTS14
uniprot id: A0A2K5U008
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:ALKAL1
gene id: 9541:ALKAL1
uniprot id: A0A8J8XRI4
uniprot id: G7PBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9541:BET1
gene id: 9541:BET1
uniprot id: A0A2K5UYH9
names: Subcellular Location Annotation
messages: Membrane

9541:BAMBI
gene id: 9541:BAMBI
uniprot id: A0A2K5TQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9541:AP5M1
gene id: 9541:AP5M1
uniprot id: A0A2K5TKA5
uniprot id: Q4R6Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.
messages: cytosol

9541:SUB1
gene id: 9541:SUB1
uniprot id: Q25NQ4
uniprot id: Q4R947
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity).
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2 (By similarity).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9541:CPLX2
gene id: 9541:CPLX2
uniprot id: A0A2K5WJI6
uniprot id: I7GKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9541:GLRA1
gene id: 9541:GLRA1
uniprot id: A0A8J8YBP3
uniprot id: G7P8R5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9541:GLRA2
gene id: 9541:GLRA2
uniprot id: A0A2K5VXB3
uniprot id: A0A7N9IDE3
uniprot id: A0A8J8YHI7
uniprot id: G7Q291
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9541:LOC102146005
gene id: 9541:LOC102146005
uniprot id: A0A2K5TMQ0
uniprot id: A0A2K5TMR6
uniprot id: I7GL08
uniprot id: Q4R5L7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9541:TIE1
gene id: 9541:TIE1
uniprot id: A0A2K5W685
uniprot id: G7NUW7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOXL3
gene id: 9541:LOXL3
uniprot id: A0A2K5X2R5
uniprot id: A0A2K5X388
uniprot id: G7PMK3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9541:ISX
gene id: 9541:ISX
uniprot id: A0A2K5U076
names: Subcellular Location Annotation
messages: Nucleus

9541:HPS3
gene id: 9541:HPS3
uniprot id: A0A2K5TN29
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9541:TPX2
gene id: 9541:TPX2
uniprot id: A0A2K5VME8
uniprot id: G7PGN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9541:LHX2
gene id: 9541:LHX2
uniprot id: A0A2K5ULQ9
names: Subcellular Location Annotation
messages: Nucleus

9541:NARF
gene id: 9541:NARF
uniprot id: A0A2K5W8L6
uniprot id: A0A2K5W8M3
names: Similarity
messages: Belongs to the NARF family.

9541:ADRA1A
gene id: 9541:ADRA1A
uniprot id: A0A2K5US01
uniprot id: A0A2K5US15
uniprot id: G7PCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9541:HDGFL2
gene id: 9541:HDGFL2
uniprot id: A0A2K5X6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9541:ELK1
gene id: 9541:ELK1
uniprot id: I7G4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:SEPTIN1
gene id: 9541:SEPTIN1
uniprot id: G7Q0X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:PLA2G4E
gene id: 9541:PLA2G4E
uniprot id: A0A2K5VTR8
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9541:CYSLTR1
gene id: 9541:CYSLTR1
uniprot id: A0A7N9C8W6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:FGG
gene id: 9541:FGG
uniprot id: A0A2K5TY00
uniprot id: A0A2K5TY07
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9541:KLC4
gene id: 9541:KLC4
uniprot id: A0A2K5WL84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9541:CHUK
gene id: 9541:CHUK
uniprot id: A0A8J8XNK4
uniprot id: G7PDQ9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:TMEM170B
gene id: 9541:TMEM170B
uniprot id: A0A2K5TPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9541:IGF1
gene id: 9541:IGF1
uniprot id: A0A2K5URR6
uniprot id: A0A2K5URS7
uniprot id: A0A2K5URV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9541:UNC93A
gene id: 9541:UNC93A
uniprot id: A0A2K5WLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9541:TIPIN
gene id: 9541:TIPIN
uniprot id: A0A2K5UYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9541:TMED6
gene id: 9541:TMED6
uniprot id: A0A8J8XY41
uniprot id: G7Q1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CYP1A1
gene id: 9541:CYP1A1
uniprot id: A0A8J8YNV8
uniprot id: G7P943
uniprot id: P33616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane

9541:NPC2
gene id: 9541:NPC2
uniprot id: P61918
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NPC2 family.
messages: Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.
messages: Detected in epididymis.
messages: Endoplasmic reticulum
messages: Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.
messages: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
messages: Lysosome
messages: Secreted

9541:KIF18B
gene id: 9541:KIF18B
uniprot id: A0A2K5W821
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:EEF2
gene id: 9541:EEF2
uniprot id: A0A2K5TK27
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9541:TRAF6
gene id: 9541:TRAF6
uniprot id: A0A2K5WZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9541:INPP5K
gene id: 9541:INPP5K
uniprot id: A0A2K5UPQ6
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9541:LAMC2
gene id: 9541:LAMC2
uniprot id: A0A2K5U9N8
uniprot id: A0A2K5U9R6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9541:FOXN3
gene id: 9541:FOXN3
uniprot id: A0A7N9CQQ7
uniprot id: A0A7N9D9G0
names: Subcellular Location Annotation
messages: Nucleus

9541:PPP2R5D
gene id: 9541:PPP2R5D
uniprot id: A0A2K5X0R2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:HSDL1
gene id: 9541:HSDL1
uniprot id: A0A8J8YE60
uniprot id: G7PZV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:ATP7B
gene id: 9541:ATP7B
uniprot id: A0A2K5TUF3
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9541:GGH
gene id: 9541:GGH
uniprot id: A0A2K5UI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9541:CBLB
gene id: 9541:CBLB
uniprot id: A0A2K5UTD4
uniprot id: A0A2K5UTD7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9541:CCL5
gene id: 9541:CCL5
uniprot id: G7PU47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:TAFA1
gene id: 9541:TAFA1
uniprot id: I7GMV7
names: Similarity
messages: Belongs to the TAFA family.

9541:SGK1
gene id: 9541:SGK1
uniprot id: A0A2K5U6V5
uniprot id: A0A2K5U6W3
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9541:SSBP4
gene id: 9541:SSBP4
uniprot id: A0A2K5WW71
uniprot id: A0A2K5WWH4
names: Subcellular Location Annotation
messages: Nucleus

9541:FGF18
gene id: 9541:FGF18
uniprot id: A0A7N9IA32
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:EDEM1
gene id: 9541:EDEM1
uniprot id: A0A2K5U245
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:TSPAN6
gene id: 9541:TSPAN6
uniprot id: A0A8J8Y336
uniprot id: G7Q377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:RBM4
gene id: 9541:RBM4
uniprot id: Q4R979
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Interacts with TNPO3; the interaction mediates nuclear import of the protein and is disrupted by nuclear Ran bound to GTP. Interacts with EIF4G1 and WT1. Interacts with EIF4A1; the interaction is modulated under stress-induced conditions. Interacts with AGO1. Interacts with AGO2; the interaction occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with DDX5; the interaction occurs in an RNA-independent manner (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated. Phosphorylated in vitro on Ser-309 by SRPK1. Phosphorylation on Ser-309 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation. Phosphorylation on Ser-309 is induced upon cell muscle differentiation (By similarity).
messages: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity).
messages: nucleolus

9541:FOXH1
gene id: 9541:FOXH1
uniprot id: A0A2K5TPR8
names: Subcellular Location Annotation
messages: Nucleus

9541:TBPL2
gene id: 9541:TBPL2
uniprot id: A0A2K5UUP4
uniprot id: G7PAC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9541:CAPG
gene id: 9541:CAPG
uniprot id: A0A2K5W9E6
uniprot id: G7PMM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9541:MPZ
gene id: 9541:MPZ
uniprot id: A0A2K5TVH9
uniprot id: G7NXB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9541:LOC102137787
gene id: 9541:LOC102137787
uniprot id: G7NW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TGFBR2
gene id: 9541:TGFBR2
uniprot id: A0A2K5WD61
uniprot id: A0A2K5WD91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9541:FAM174C
gene id: 9541:FAM174C
uniprot id: A0A2K5VFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:USH2A
gene id: 9541:USH2A
uniprot id: A0A2K5VJD4
uniprot id: A0A2K5VJI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MRRF
gene id: 9541:MRRF
uniprot id: A0A2K5VLD5
uniprot id: A0A2K5VLI5
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9541:CPOX
gene id: 9541:CPOX
uniprot id: A0A2K5WTC0
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9541:SLC37A1
gene id: 9541:SLC37A1
uniprot id: A0A2K5U679
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9541:PGBD1
gene id: 9541:PGBD1
uniprot id: A0A2K5W0M4
names: Subcellular Location Annotation
messages: Nucleus

9541:SAP18
gene id: 9541:SAP18
uniprot id: I7G2D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP18 family.
messages: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
messages: Cytoplasm
messages: Nucleus speckle

9541:RBM17
gene id: 9541:RBM17
uniprot id: A0A2K5V9A1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9541:CDC26
gene id: 9541:CDC26
uniprot id: A0A8J8XAK7
uniprot id: G7PRM8
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9541:FBXO32
gene id: 9541:FBXO32
uniprot id: A0A2K5X1L4
names: Subcellular Location Annotation
messages: Nucleus

9541:ADGRG1
gene id: 9541:ADGRG1
uniprot id: A0A2K5TYF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9541:HSD17B3
gene id: 9541:HSD17B3
uniprot id: A0A2K5TM58
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:SLITRK5
gene id: 9541:SLITRK5
uniprot id: A0A2K5TPB5
names: Similarity
messages: Belongs to the SLITRK family.

9541:RBP4
gene id: 9541:RBP4
uniprot id: A0A2K5W172
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9541:DAPK2
gene id: 9541:DAPK2
uniprot id: A0A2K5ULA9
uniprot id: G7P8U1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:EIF4G1
gene id: 9541:EIF4G1
uniprot id: A0A2K5WFL9
uniprot id: A0A2K5WFS2
uniprot id: A0A2K5WFX9
uniprot id: G7NYZ8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9541:TRMT2A
gene id: 9541:TRMT2A
uniprot id: A0A2K5WNL5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DIS3L
gene id: 9541:DIS3L
uniprot id: A0A2K5V9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

9541:RBCK1
gene id: 9541:RBCK1
uniprot id: A0A2K5VYQ0
uniprot id: A0A2K5VYQ4
names: Similarity
messages: Belongs to the RBR family.

9541:RTN2
gene id: 9541:RTN2
uniprot id: A0A2K5U0A3
uniprot id: A0A2K5U0B4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SLC35C2
gene id: 9541:SLC35C2
uniprot id: A0A2K5VXX1
names: Subcellular Location Annotation
messages: Membrane

9541:PITX3
gene id: 9541:PITX3
uniprot id: A0A2K5VRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9541:MRPL36
gene id: 9541:MRPL36
uniprot id: G8F2L2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9541:HSPA4
gene id: 9541:HSPA4
uniprot id: A0A2K5UMB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9541:LOC102139145
gene id: 9541:LOC102139145
uniprot id: A0A2K5UK15
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9541:TASOR2
gene id: 9541:TASOR2
uniprot id: A0A2K5X7Q8
names: Similarity
messages: Belongs to the TASOR family.

9541:CRYBG3
gene id: 9541:CRYBG3
uniprot id: A0A2K5WRQ9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:KDM1A
gene id: 9541:KDM1A
uniprot id: A0A2K5TKW6
uniprot id: A0A2K5TKZ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9541:GPR137B
gene id: 9541:GPR137B
uniprot id: A0A2K5UBH1
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9541:DLX2
gene id: 9541:DLX2
uniprot id: A0A2K5VRP7
names: Subcellular Location Annotation
messages: Nucleus

9541:GK5
gene id: 9541:GK5
uniprot id: A0A2K5TT23
uniprot id: A0A7N9IBB2
names: Similarity
messages: Belongs to the FGGY kinase family.

9541:GTF2E2
gene id: 9541:GTF2E2
uniprot id: A0A8J8XTQ5
uniprot id: G7PD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9541:ACAD9
gene id: 9541:ACAD9
uniprot id: A0A2K5VRB8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:VENTX
gene id: 9541:VENTX
uniprot id: A0A2K5UA13
names: Subcellular Location Annotation
messages: Nucleus

9541:CXCL1
gene id: 9541:CXCL1
uniprot id: Q0EAC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:SLCO2A1
gene id: 9541:SLCO2A1
uniprot id: Q4R830
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:OSBPL5
gene id: 9541:OSBPL5
uniprot id: A0A2K5V8V6
names: Similarity
messages: Belongs to the OSBP family.

9541:COG7
gene id: 9541:COG7
uniprot id: A0A8J8XHI7
uniprot id: G7Q0Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:ALKBH8
gene id: 9541:ALKBH8
uniprot id: A0A2K5W8D0
uniprot id: Q95K79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).
messages: Cytoplasm
messages: Interacts with TRMT112.
messages: Nucleus

9541:LHFPL4
gene id: 9541:LHFPL4
uniprot id: A0A2K5V7P4
names: Subcellular Location Annotation
messages: Membrane

9541:ISL2
gene id: 9541:ISL2
uniprot id: A0A2K5V3G6
names: Subcellular Location Annotation
messages: Nucleus

9541:PDC
gene id: 9541:PDC
uniprot id: A0A2K5U750
uniprot id: G7NXE9
names: Similarity
messages: Belongs to the phosducin family.

9541:CDH18
gene id: 9541:CDH18
uniprot id: A0A2K5UPM6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:RABEP2
gene id: 9541:RABEP2
uniprot id: Q4R6D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Early endosome
messages: Endosome
messages: centrosome
messages: cilium basal body

9541:PVALB
gene id: 9541:PVALB
uniprot id: A0A2K5VH89
uniprot id: G7PFB9
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9541:OXT
gene id: 9541:OXT
uniprot id: I7G319
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9541:XPO1
gene id: 9541:XPO1
uniprot id: A0A2K5WNY6
uniprot id: A0A7N9CMG1
uniprot id: G7PMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9541:ZC3H12A
gene id: 9541:ZC3H12A
uniprot id: A0A2K5V3E9
names: Similarity
messages: Belongs to the ZC3H12 family.

9541:TMTC4
gene id: 9541:TMTC4
uniprot id: A0A2K5VJL1
uniprot id: A0A2K5VJM6
uniprot id: A0A7N9DB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:ABCG8
gene id: 9541:ABCG8
uniprot id: A0A2K5VTH8
uniprot id: G7PM41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9541:ALX3
gene id: 9541:ALX3
uniprot id: A0A2K5X833
names: Subcellular Location Annotation
messages: Nucleus

9541:ATP8B1
gene id: 9541:ATP8B1
uniprot id: A0A2K5U251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9541:CPPED1
gene id: 9541:CPPED1
uniprot id: A0A2K5W4Y7
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9541:MIOS
gene id: 9541:MIOS
uniprot id: A0A2K5WH75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9541:SDHC
gene id: 9541:SDHC
uniprot id: A0A2K5VYJ1
uniprot id: A0A2K5VYL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9541:ANP32A
gene id: 9541:ANP32A
uniprot id: I7GHD6
names: Similarity
messages: Belongs to the ANP32 family.

9541:RNASEK
gene id: 9541:RNASEK
uniprot id: I7GKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

9541:ODF2L
gene id: 9541:ODF2L
uniprot id: A0A2K5UGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9541:MRPL14
gene id: 9541:MRPL14
uniprot id: G7P402
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9541:CKB
gene id: 9541:CKB
uniprot id: A0A2K5WBF5
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9541:BMPR1B
gene id: 9541:BMPR1B
uniprot id: A0A2K5W4N9
uniprot id: A0A2K5W4R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:LOC102126703
gene id: 9541:LOC102126703
uniprot id: A0A2K5TPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:USP2
gene id: 9541:USP2
uniprot id: A0A2K5U4E6
uniprot id: A0A8J8XDN1
uniprot id: G7PPB3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:TBL3
gene id: 9541:TBL3
uniprot id: A0A2K5UQ25
names: Subcellular Location Annotation
messages: nucleolus

9541:MAPRE2
gene id: 9541:MAPRE2
uniprot id: A0A2K5X8Q4
uniprot id: A0A2K5X8R3
uniprot id: A0A2K5X8U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

9541:CCNJL
gene id: 9541:CCNJL
uniprot id: A0A2K5TXX7
uniprot id: A0A2K5TXX8
names: Similarity
messages: Belongs to the cyclin family.

9541:LOC102128296
gene id: 9541:LOC102128296
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:PALM2AKAP2
gene id: 9541:PALM2AKAP2
uniprot id: A0A2K5UC33
names: Similarity
messages: Belongs to the paralemmin family.

9541:CD151
gene id: 9541:CD151
uniprot id: A0A2K5WB08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:POLR2M
gene id: 9541:POLR2M
uniprot id: A0A2K5V9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9541:CFL1
gene id: 9541:CFL1
uniprot id: Q4R5C0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin-binding proteins ADF family.
messages: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
messages: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (By similarity). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).
messages: Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).
messages: Nucleus matrix
messages: axon
messages: cytoskeleton
messages: growth cone
messages: lamellipodium
messages: lamellipodium membrane
messages: ruffle membrane

9541:LOC102139623
gene id: 9541:LOC102139623
uniprot id: A0A2K5VL90
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9541:ILK
gene id: 9541:ILK
uniprot id: A0A2K5WGD3
uniprot id: A0A2K5WGG1
uniprot id: G7PQV1
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9541:PNLDC1
gene id: 9541:PNLDC1
uniprot id: A0A2K5WVD2
names: Similarity
messages: Belongs to the CAF1 family.

9541:COPZ1
gene id: 9541:COPZ1
uniprot id: A0A2K5V909
uniprot id: A0A7N9CQ73
uniprot id: G8F5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9541:SCML2
gene id: 9541:SCML2
uniprot id: A0A2K5W0N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9541:SNRPB
gene id: 9541:SNRPB
uniprot id: A0A2K5WP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9541:RHCG
gene id: 9541:RHCG
uniprot id: A0A8J8XKZ0
uniprot id: G7P9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9541:MRPL40
gene id: 9541:MRPL40
uniprot id: A0A8J8YSK4
uniprot id: G7PH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9541:TSPAN3
gene id: 9541:TSPAN3
uniprot id: A0A2K5UZ83
uniprot id: A0A2K5UZ94
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FABP4
gene id: 9541:FABP4
uniprot id: A0A8J8YKQ0
uniprot id: G7PC40
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:SSBP1
gene id: 9541:SSBP1
uniprot id: A0A7N9C9N4
uniprot id: A0A8J8XDD0
uniprot id: G7P1E9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9541:TTC39B
gene id: 9541:TTC39B
uniprot id: A0A2K5TYU0
uniprot id: A0A2K5TYV0
uniprot id: Q95LT8
names: Function
names: Similarity
messages: Belongs to the TTC39 family.
messages: Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).

9541:PAQR8
gene id: 9541:PAQR8
uniprot id: A0A2K5UC52
uniprot id: G7P4V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:MAP4K2
gene id: 9541:MAP4K2
uniprot id: A0A2K5VBY9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9541:PLXNA4
gene id: 9541:PLXNA4
uniprot id: A0A2K5VVJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SPTBN2
gene id: 9541:SPTBN2
uniprot id: A0A2K5W2X6
names: Similarity
messages: Belongs to the spectrin family.

9541:LOC101925219
gene id: 9541:LOC101925219
uniprot id: A0A2K5VS48
uniprot id: A0A2K5VS77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9541:RPL10
gene id: 9541:RPL10
uniprot id: A0A8J8XDM4
uniprot id: G7Q3B3
uniprot id: Q4R7Y2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Ufmylated by UFL1.

9541:FOXI1
gene id: 9541:FOXI1
uniprot id: A0A2K5UFG3
names: Subcellular Location Annotation
messages: Nucleus

9541:CBFA2T2
gene id: 9541:CBFA2T2
uniprot id: A0A2K5U9Z9
names: Similarity
messages: Belongs to the CBFA2T family.

9541:HMCES
gene id: 9541:HMCES
uniprot id: A0A2K5V147
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9541:ENO3
gene id: 9541:ENO3
uniprot id: A0A2K5URN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9541:COQ8A
gene id: 9541:COQ8A
uniprot id: A0A2K5VRC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9541:ZHX1
gene id: 9541:ZHX1
uniprot id: A0A2K5UIR8
uniprot id: G7PCR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9541:ABITRAM
gene id: 9541:ABITRAM
uniprot id: A0A2K5W2H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9541:TTYH1
gene id: 9541:TTYH1
uniprot id: A0A2K5UUE6
uniprot id: A0A2K5UUF4
uniprot id: Q9MZZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.
messages: Probable chloride channel. May be involved in cell adhesion (By similarity).

9541:LOC102130495
gene id: 9541:LOC102130495
uniprot id: A0A8J8XAW2
uniprot id: G7P5Z7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:PDSS2
gene id: 9541:PDSS2
uniprot id: A0A8J8XRJ7
uniprot id: G7P454
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:RPL35A
gene id: 9541:RPL35A
uniprot id: G8F3S7
uniprot id: P61272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL33 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.
messages: Cytoplasm

9541:TATDN3
gene id: 9541:TATDN3
uniprot id: A0A2K5TT38
uniprot id: A0A2K5TT59
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9541:DDX1
gene id: 9541:DDX1
uniprot id: Q4R7L5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (By similarity). Interacts with DHX36 (By similarity). Interacts (via B30.2/SPRY domain) with DDX21 (via N-terminus); this interaction serves as bridges to TICAM1 (By similarity). Interacts with FAM98A (via N- and C-terminus) (By similarity). Interacts with PHF5A (via C-terminus) (By similarity). Interacts with MBNL1 (By similarity). Interacts with CSTF2 (By similarity). Interacts with HNRNPK (By similarity). Interacts with ATM (By similarity). Interacts with RELA (via C-terminus) (By similarity). Component of the tRNA-splicing ligase complex (By similarity). Interacts with PQBP1 (By similarity). Interacts with ERCC6 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.
messages: cytosol

9541:EPHA3
gene id: 9541:EPHA3
uniprot id: A0A2K5UU29
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102146205
gene id: 9541:LOC102146205
uniprot id: A0A088G4T6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:ZP4
gene id: 9541:ZP4
uniprot id: A0A2K5U9W9
uniprot id: Q861S0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9541:SIKE1
gene id: 9541:SIKE1
uniprot id: A0A2K5V835
uniprot id: A0A7N9CJ40
names: Similarity
messages: Belongs to the SIKE family.

9541:CRMP1
gene id: 9541:CRMP1
uniprot id: A0A2K5X6Z7
uniprot id: A0A2K5X7G4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9541:SYNM
gene id: 9541:SYNM
uniprot id: A0A2K5U4W1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102140349
gene id: 9541:LOC102140349
uniprot id: A0A2K5WJ62
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9541:PEX1
gene id: 9541:PEX1
uniprot id: A0A2K5VU68
uniprot id: A0A2K5VU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9541:CFAP43
gene id: 9541:CFAP43
uniprot id: A0A2K5VH82
names: Similarity
messages: Belongs to the CFAP43 family.

9541:SEMA3C
gene id: 9541:SEMA3C
uniprot id: A0A2K5X715
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ST8SIA5
gene id: 9541:ST8SIA5
uniprot id: A0A2K5VBL0
uniprot id: A0A2K5VBP9
uniprot id: A0A2K5VBQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:ETV3L
gene id: 9541:ETV3L
uniprot id: A0A2K5TRN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:SEPTIN12
gene id: 9541:SEPTIN12
uniprot id: A0A2K5VJ77
uniprot id: A0A8J8YJG8
uniprot id: G7Q0E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:SCG2
gene id: 9541:SCG2
uniprot id: Q4R5E9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9541:SLC39A14
gene id: 9541:SLC39A14
uniprot id: A0A2K5W9K8
uniprot id: A0A2K5W9L7
names: Subcellular Location Annotation
messages: Membrane

9541:PROZ
gene id: 9541:PROZ
uniprot id: A0A2K5VZQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NSG1
gene id: 9541:NSG1
uniprot id: Q4R5Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (By similarity).
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
messages: Recycling endosome membrane
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

9541:NME6
gene id: 9541:NME6
uniprot id: A0A2K5X2N1
uniprot id: G8F304
uniprot id: I7GCU7
names: Similarity
messages: Belongs to the NDK family.

9541:ORMDL3
gene id: 9541:ORMDL3
uniprot id: A0A8J8XRK2
uniprot id: G7PUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9541:MYO10
gene id: 9541:MYO10
uniprot id: A0A2K5VRV0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ARL3
gene id: 9541:ARL3
uniprot id: A0A7N9CAA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9541:ESRP1
gene id: 9541:ESRP1
uniprot id: A0A2K5UWK5
uniprot id: A0A2K5UWL1
uniprot id: A0A2K5UWQ8
uniprot id: G7PC86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

9541:CCN3
gene id: 9541:CCN3
uniprot id: A0A2K5ULD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:B3GAT2
gene id: 9541:B3GAT2
uniprot id: A0A2K5WUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:ADAMTS16
gene id: 9541:ADAMTS16
uniprot id: A0A2K5X8E2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:SYCP2
gene id: 9541:SYCP2
uniprot id: A0A2K5X7R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

9541:LOC102131151
gene id: 9541:LOC102131151
uniprot id: A0A2K5UAI4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9541:CYP2B6
gene id: 9541:CYP2B6
uniprot id: B8K1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:PPP1R1A
gene id: 9541:PPP1R1A
uniprot id: I7G6I7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9541:CXXC1
gene id: 9541:CXXC1
uniprot id: A0A2K5TNU8
names: Subcellular Location Annotation
messages: Nucleus

9541:APOBEC2
gene id: 9541:APOBEC2
uniprot id: A0A2K5VNN4
uniprot id: G7P3F1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SEC31A
gene id: 9541:SEC31A
uniprot id: A0A2K5TTM3
uniprot id: A0A2K5TTM4
uniprot id: A0A2K5TTM7
uniprot id: A0A2K5TTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102115085
gene id: 9541:LOC102115085
uniprot id: A0A2K5UAP9
uniprot id: G7P1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:RNF10
gene id: 9541:RNF10
uniprot id: A0A2K5WUW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9541:DMAC2L
gene id: 9541:DMAC2L
uniprot id: A0A2K5VY90
uniprot id: A0A7N9CIX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9541:AQP8
gene id: 9541:AQP8
uniprot id: A0A2K5WMQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:PHKB
gene id: 9541:PHKB
uniprot id: A0A2K5VG98
uniprot id: A0A2K5VGD8
uniprot id: G7Q125
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9541:ADGRG6
gene id: 9541:ADGRG6
uniprot id: A0A2K5U7W4
uniprot id: A0A2K5U7W9
uniprot id: A0A2K5U7X0
uniprot id: A0A2K5U820
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ARAP2
gene id: 9541:ARAP2
uniprot id: A0A2K5WW63
uniprot id: A0A2K5WWF2
names: Subcellular Location Annotation
messages: Cytoplasm

9541:LOC102117012
gene id: 9541:LOC102117012
uniprot id: A0A7N9D238
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CAPN5
gene id: 9541:CAPN5
uniprot id: A0A2K5VDC5
names: Similarity
messages: Belongs to the peptidase C2 family.

9541:LOC102116883
gene id: 9541:LOC102116883
uniprot id: A0A2K5VGQ7
names: Subcellular Location Annotation
messages: Membrane

9541:ACO2
gene id: 9541:ACO2
uniprot id: A0A2K5VHM1
uniprot id: A0A7N9D0G3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9541:BRINP2
gene id: 9541:BRINP2
uniprot id: A0A2K5TQM2
names: Similarity
messages: Belongs to the BRINP family.

9541:PUS10
gene id: 9541:PUS10
uniprot id: A0A2K5X8M0
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9541:VIPAS39
gene id: 9541:VIPAS39
uniprot id: G7PB33
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9541:RNF32
gene id: 9541:RNF32
uniprot id: Q4R5T4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in sperm formation.

9541:DCAF11
gene id: 9541:DCAF11
uniprot id: A0A2K5UGV9
uniprot id: A0A2K5UGW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9541:HHATL
gene id: 9541:HHATL
uniprot id: A0A8J8YIJ7
uniprot id: G7NY66
names: Subcellular Location Annotation
messages: Membrane

9541:CDPF1
gene id: 9541:CDPF1
uniprot id: A0A2K5UQT7
names: Similarity
messages: Belongs to the CDPF1 family.

9541:SERF2
gene id: 9541:SERF2
uniprot id: A0A2K5TR10
names: Similarity
messages: Belongs to the SERF family.

9541:SPO11
gene id: 9541:SPO11
uniprot id: A0A2K5UV77
names: Similarity
messages: Belongs to the TOP6A family.

9541:SERPINB2
gene id: 9541:SERPINB2
uniprot id: A0A2K5VAJ6
names: Similarity
messages: Belongs to the serpin family.

9541:TOR1B
gene id: 9541:TOR1B
uniprot id: A0A2K5WSY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9541:MYO1A
gene id: 9541:MYO1A
uniprot id: A0A2K5VMC9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:HIP1R
gene id: 9541:HIP1R
uniprot id: A0A2K5WTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

9541:GTF3C5
gene id: 9541:GTF3C5
uniprot id: Q4R835
names: Subcellular Location Annotation
messages: Nucleus

9541:HMBOX1
gene id: 9541:HMBOX1
uniprot id: A0A2K5V9Z2
uniprot id: A0A2K5V9Z7
uniprot id: A0A7N9CEA4
uniprot id: A0A7N9D4V8
uniprot id: G7PD48
names: Subcellular Location Annotation
messages: Nucleus

9541:SSU72
gene id: 9541:SSU72
uniprot id: A0A2K5X3K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9541:SLC39A13
gene id: 9541:SLC39A13
uniprot id: A0A2K5W9X4
names: Subcellular Location Annotation
messages: Membrane

9541:PCNX4
gene id: 9541:PCNX4
uniprot id: A0A2K5V2Y0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MINDY2
gene id: 9541:MINDY2
uniprot id: A0A2K5V6J1
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9541:WFIKKN2
gene id: 9541:WFIKKN2
uniprot id: A0A2K5VVF3
names: Similarity
messages: Belongs to the WFIKKN family.

9541:LOC101867156
gene id: 9541:LOC101867156
uniprot id: A0A2K5V0M7
uniprot id: A0A8J8XCF7
uniprot id: G7P9V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Nucleus

9541:INPP1
gene id: 9541:INPP1
uniprot id: A0A2K5UZL8
uniprot id: G7PL18
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9541:KCND1
gene id: 9541:KCND1
uniprot id: A0A2K5UZL1
uniprot id: G7Q2P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9541:POGLUT2
gene id: 9541:POGLUT2
uniprot id: A0A2K5VRS9
names: Similarity
messages: Belongs to the KDELC family.

9541:DNAH9
gene id: 9541:DNAH9
uniprot id: A0A2K5U1E2
names: Similarity
messages: Belongs to the dynein heavy chain family.

9541:LGALS3
gene id: 9541:LGALS3
uniprot id: A0A2K5U233
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:CADM3
gene id: 9541:CADM3
uniprot id: A0A2K5UJL5
names: Similarity
messages: Belongs to the nectin family.

9541:FSCN3
gene id: 9541:FSCN3
uniprot id: A0A2K5W420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9541:IL1A
gene id: 9541:IL1A
uniprot id: Q4R4F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9541:TMEFF2
gene id: 9541:TMEFF2
uniprot id: A0A2K5UWD7
uniprot id: G7PL27
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102119473
gene id: 9541:LOC102119473
uniprot id: A0A2K5WI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9541:ACP2
gene id: 9541:ACP2
uniprot id: Q4R5N9
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family.
messages: Lysosome lumen
messages: Lysosome membrane
messages: The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity).

9541:GALNS
gene id: 9541:GALNS
uniprot id: A0A2K5VWH7
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:GART
gene id: 9541:GART
uniprot id: A0A2K5WK72
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9541:FAM151A
gene id: 9541:FAM151A
uniprot id: A0A2K5TS87
names: Similarity
messages: Belongs to the FAM151 family.

9541:FERMT1
gene id: 9541:FERMT1
uniprot id: A0A2K5WEF8
names: Similarity
messages: Belongs to the kindlin family.

9541:C1GALT1
gene id: 9541:C1GALT1
uniprot id: A0A2K5UWB6
uniprot id: A0A2K5UWK3
uniprot id: A0A7N9CVW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9541:TSEN54
gene id: 9541:TSEN54
uniprot id: A0A2K5X978
names: Similarity
messages: Belongs to the SEN54 family.

9541:AKR1C1
gene id: 9541:AKR1C1
uniprot id: I7G981
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:MRPL10
gene id: 9541:MRPL10
uniprot id: A0A2K5UPN5
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9541:RUNX1T1
gene id: 9541:RUNX1T1
uniprot id: A0A2K5V2S4
uniprot id: A0A2K5V2T1
uniprot id: G7PC74
uniprot id: Q2PG35
names: Similarity
messages: Belongs to the CBFA2T family.

9541:MCOLN1
gene id: 9541:MCOLN1
uniprot id: Q60HE8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily.
messages: Cell membrane
messages: Channel activity is controlled by multiple regulatory mechanisms in different subcellular compartments. Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels; a negative cooperativity between extracellular/lumenal Ca(2+) and H(+) is suggested. Regulated by phosphoinositides in a compartment-specific manner: in lysosomes activated by PtdIns(3,5)P2 (Phosphatidylinositol 3,5-bisphosphate) and at the plasma membrane inhibited by PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate).
messages: Cytoplasmic vesicle membrane
messages: Homotetramer. Homooligomer. Can heterooligomerize with MCOLN2 or MCOLN3; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. Interacts with PDCD6. Interacts with TMEM163. Interacts with LAPTM4B.
messages: Late endosome membrane
messages: Lysosome membrane
messages: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.
messages: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels. Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy. Functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells.
messages: Palmitoylated; involved in association with membranes.
messages: Phosphorylation by PKA inhibits channel activity. Dephosphorylation increases activity.
messages: Proteolytically cleaved probably involving multiple lysosomal proteases including cathepsin B; inhibits lysosomal channel activity.
messages: The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.
messages: phagocytic cup
messages: phagosome membrane

9541:CHAC1
gene id: 9541:CHAC1
uniprot id: A0A2K5VHG6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9541:TIMM17B
gene id: 9541:TIMM17B
uniprot id: A0A2K5UAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DLX1
gene id: 9541:DLX1
uniprot id: A0A8J8YK27
uniprot id: G7PKU0
uniprot id: I7GIQ8
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102129793
gene id: 9541:LOC102129793
uniprot id: A0A2K5W0U2
uniprot id: A0A2K5W142
uniprot id: G7P1S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9541:EGFLAM
gene id: 9541:EGFLAM
uniprot id: A0A2K5TUL9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MEA1
gene id: 9541:MEA1
uniprot id: A0A7N9CLZ5
uniprot id: A0A8J8Y7N4
uniprot id: G7P3Y9
uniprot id: Q4R992
names: Caution
names: Function
messages: It is uncertain whether Met-1 or Met-11 is the initiator.
messages: May play an important role in spermatogenesis and/or testis development.

9541:LOC101866469
gene id: 9541:LOC101866469
uniprot id: G7P578
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9541:CA14
gene id: 9541:CA14
uniprot id: A0A2K5TRM8
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9541:CFAP97
gene id: 9541:CFAP97
uniprot id: A0A2K5UDK2
uniprot id: A0A2K5UDP0
names: Similarity
messages: Belongs to the CFAP97 family.

9541:WNT2B
gene id: 9541:WNT2B
uniprot id: A0A2K5TYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:CYP2A13
gene id: 9541:CYP2A13
uniprot id: A0A2K5V274
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:CDC73
gene id: 9541:CDC73
uniprot id: A0A8J8YD42
uniprot id: G7NXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9541:MRGPRD
gene id: 9541:MRGPRD
uniprot id: A0A7N9CGP4
names: Subcellular Location Annotation
messages: Cell membrane

9541:ZSCAN29
gene id: 9541:ZSCAN29
uniprot id: A0A2K5X625
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:AASDH
gene id: 9541:AASDH
uniprot id: A0A2K5V8Q1
uniprot id: A0A7N9CGA7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:ISCA2
gene id: 9541:ISCA2
uniprot id: A0A7N9CFA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9541:RPS6KA6
gene id: 9541:RPS6KA6
uniprot id: A0A2K5U185
uniprot id: A0A2K5U1B3
uniprot id: A0A2K5U1F5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:PPP2CB
gene id: 9541:PPP2CB
uniprot id: A0A2K5X5X2
names: Similarity
messages: Belongs to the PPP phosphatase family.

9541:CCKAR
gene id: 9541:CCKAR
uniprot id: A0A2K5WAE8
uniprot id: G7P5D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9541:PIPOX
gene id: 9541:PIPOX
uniprot id: A0A2K5UKU2
uniprot id: A0A7N9CUM7
uniprot id: G8F5H8
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9541:LOC102144964
gene id: 9541:LOC102144964
uniprot id: A0A8J8XVN4
uniprot id: G7NTR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SMUG1
gene id: 9541:SMUG1
uniprot id: A0A2K5WLY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9541:SLC28A3
gene id: 9541:SLC28A3
uniprot id: A0A2K5WBF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9541:RAB4B
gene id: 9541:RAB4B
uniprot id: A0A2K5V7T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9541:GPM6B
gene id: 9541:GPM6B
uniprot id: A0A2K5WHV9
uniprot id: A0A2K5WHX3
uniprot id: G7Q290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9541:RAP1B
gene id: 9541:RAP1B
uniprot id: Q4R9D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
messages: Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: cytosol

9541:LCE5A
gene id: 9541:LCE5A
uniprot id: A0A2K5UNK6
uniprot id: G8F3E4
names: Similarity
messages: Belongs to the LCE family.

9541:TMEM198
gene id: 9541:TMEM198
uniprot id: I7GF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9541:CNEP1R1
gene id: 9541:CNEP1R1
uniprot id: A0A7N9D9L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9541:GGT7
gene id: 9541:GGT7
uniprot id: A0A2K5WT09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9541:SAMHD1
gene id: 9541:SAMHD1
uniprot id: K4JU89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9541:PCYT1B
gene id: 9541:PCYT1B
uniprot id: A0A2K5U167
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9541:TSPYL2
gene id: 9541:TSPYL2
uniprot id: Q9BE64
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: By TGFB1 and all-trans retinoic acid in lung cells (at protein level).
messages: Cytoplasm
messages: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
messages: Nucleus
messages: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity).
messages: Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
messages: Subject to X inactivation.
messages: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.
messages: Ubiquitously expressed, with highest levels in testis, adrenal gland, cerebral cortex, ovary, skeletal muscle and spleen. Present in testis, adrenal gland, cerebral cortex and ovary (at protein level).

9541:REXO2
gene id: 9541:REXO2
uniprot id: G7PP03
names: Similarity
messages: Belongs to the oligoribonuclease family.

9541:TMEM161B
gene id: 9541:TMEM161B
uniprot id: A0A2K5VDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9541:LOC102136480
gene id: 9541:LOC102136480
uniprot id: A0A2K5VTT8
uniprot id: A0A2K5VTY6
names: Similarity
messages: Belongs to the AKAP110 family.

9541:LOC102122430
gene id: 9541:LOC102122430
uniprot id: A0A2K5TR05
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:SPATA16
gene id: 9541:SPATA16
uniprot id: Q4R3V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATA16 family.
messages: Essential for spermiogenesis and male fertility (By similarity). Involved in the formation of sperm acrosome during spermatogenesis (By similarity).
messages: Golgi apparatus
messages: acrosome

9541:SERPINB10
gene id: 9541:SERPINB10
uniprot id: A0A2K5V9V3
names: Similarity
messages: Belongs to the serpin family.

9541:ZCCHC4
gene id: 9541:ZCCHC4
uniprot id: A0A2K5TQX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9541:INSM2
gene id: 9541:INSM2
uniprot id: A0A2K5UEF6
names: Subcellular Location Annotation
messages: Nucleus

9541:IHH
gene id: 9541:IHH
uniprot id: A0A2K5TS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9541:LOC101926212
gene id: 9541:LOC101926212
uniprot id: A0A7N9D6B3
uniprot id: Q4R7K2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC101926462
gene id: 9541:LOC101926462
uniprot id: A0A2K5TL41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9541:ZNF449
gene id: 9541:ZNF449
uniprot id: A0A2K5WPM8
uniprot id: A0A8J8XYN0
names: Subcellular Location Annotation
messages: Nucleus

9541:RAPSN
gene id: 9541:RAPSN
uniprot id: A0A2K5WJX9
names: Similarity
messages: Belongs to the RAPsyn family.

9541:LOC102137836
gene id: 9541:LOC102137836
uniprot id: A0A2K5VEZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9541:CDH13
gene id: 9541:CDH13
uniprot id: A0A2K5W8H7
uniprot id: A0A2K5W8I7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

9541:CSGALNACT1
gene id: 9541:CSGALNACT1
uniprot id: A0A2K5VQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9541:LPIN1
gene id: 9541:LPIN1
uniprot id: A0A2K5VB78
uniprot id: A0A2K5VB83
uniprot id: A0A2K5VBA0
uniprot id: A0A2K5VBB5
uniprot id: A0A7N9D8W5
names: Similarity
messages: Belongs to the lipin family.

9541:ACTN2
gene id: 9541:ACTN2
uniprot id: A0A2K5VVV0
uniprot id: A0A2K5VVZ5
names: Similarity
messages: Belongs to the alpha-actinin family.

9541:BTC
gene id: 9541:BTC
uniprot id: A0A2K5X5E5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FOXI3
gene id: 9541:FOXI3
uniprot id: A0A2K5VZU5
names: Subcellular Location Annotation
messages: Nucleus

9541:ODAM
gene id: 9541:ODAM
uniprot id: A0A2K5VPB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9541:VPS36
gene id: 9541:VPS36
uniprot id: A0A2K5VZ22
uniprot id: A0A2K5VZ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9541:USP14
gene id: 9541:USP14
uniprot id: A0A2K5U7K2
uniprot id: A0A2K5U7L4
uniprot id: A0A7N9CZD4
uniprot id: I7GI76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9541:ADAMDEC1
gene id: 9541:ADAMDEC1
uniprot id: A0A2K5UDE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DHCR7
gene id: 9541:DHCR7
uniprot id: A0A2K5W7E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9541:TPI1
gene id: 9541:TPI1
uniprot id: Q60HC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9541:CPE
gene id: 9541:CPE
uniprot id: Q4R4M3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with secretogranin III/SCG3.
messages: Secreted
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: secretory vesicle
messages: secretory vesicle membrane

9541:RBP7
gene id: 9541:RBP7
uniprot id: A0A2K5TNM0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:ZSCAN22
gene id: 9541:ZSCAN22
uniprot id: A0A2K5WM71
names: Subcellular Location Annotation
messages: Nucleus

9541:CHD2
gene id: 9541:CHD2
uniprot id: A0A2K5VAF0
uniprot id: A0A7N9IG37
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102146459
gene id: 9541:LOC102146459
uniprot id: A0A8J8YEU4
uniprot id: G7Q3I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9541:ATRN
gene id: 9541:ATRN
uniprot id: A0A2K5U1W6
uniprot id: A0A2K5U1W7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CALCA
gene id: 9541:CALCA
uniprot id: A0A2K5VW68
names: Similarity
messages: Belongs to the calcitonin family.

9541:LOC102140170
gene id: 9541:LOC102140170
uniprot id: A0A2K5U3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9541:CMTM8
gene id: 9541:CMTM8
uniprot id: A0A2K5UTJ6
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102137606
gene id: 9541:LOC102137606
uniprot id: A0A2K5WP89
uniprot id: A0A2K5WPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9541:MMP12
gene id: 9541:MMP12
uniprot id: A0A8J8YBR3
uniprot id: G7PNK7
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:PIK3C3
gene id: 9541:PIK3C3
uniprot id: A0A2K5WEV7
uniprot id: A0A2K5WF49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9541:RAB3C
gene id: 9541:RAB3C
uniprot id: A0A7N9CIY2
uniprot id: A0A8J8XFS3
uniprot id: G7P7K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9541:TRIM23
gene id: 9541:TRIM23
uniprot id: A0A2K5X6K7
uniprot id: G7P7M3
names: Subcellular Location Annotation
messages: Nucleus

9541:GABARAPL2
gene id: 9541:GABARAPL2
uniprot id: I7GJ90
names: Similarity
messages: Belongs to the ATG8 family.

9541:RNF126
gene id: 9541:RNF126
uniprot id: A0A2K5U781
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:SIX4
gene id: 9541:SIX4
uniprot id: A0A2K5VWJ2
names: Subcellular Location Annotation
messages: Nucleus

9541:TNIP2
gene id: 9541:TNIP2
uniprot id: A0A2K5WAV3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:UGT3A2
gene id: 9541:UGT3A2
uniprot id: A0A2K5WFP5
uniprot id: A0A7G0UDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:PKP1
gene id: 9541:PKP1
uniprot id: A0A2K5WB38
names: Similarity
messages: Belongs to the beta-catenin family.

9541:FCN1
gene id: 9541:FCN1
uniprot id: A0A2K5W5Q9
names: Similarity
messages: Belongs to the ficolin lectin family.

9541:EBF4
gene id: 9541:EBF4
uniprot id: A0A2K5V061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9541:CERCAM
gene id: 9541:CERCAM
uniprot id: A0A2K5TVP7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9541:LOC102133014
gene id: 9541:LOC102133014
uniprot id: A0A2K5W8U4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9541:GPX8
gene id: 9541:GPX8
uniprot id: A0A7N9CZP0
uniprot id: G7P7I5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9541:GTPBP1
gene id: 9541:GTPBP1
uniprot id: A0A2K5TMJ7
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

9541:HOXB1
gene id: 9541:HOXB1
uniprot id: A0A7N9D9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9541:HINT1
gene id: 9541:HINT1
uniprot id: A0A2K5TM01
names: Similarity
messages: Belongs to the HINT family.

9541:G2E3
gene id: 9541:G2E3
uniprot id: Q4R9C4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
messages: Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
messages: nucleolus

9541:TCAF1
gene id: 9541:TCAF1
uniprot id: G8F2M5
names: Similarity
messages: Belongs to the TCAF family.

9541:MUS81
gene id: 9541:MUS81
uniprot id: A0A2K5U706
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9541:BCAR1
gene id: 9541:BCAR1
uniprot id: A0A2K5TLU8
uniprot id: A0A2K5TLV1
uniprot id: A0A2K5TLV2
uniprot id: A0A2K5TLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9541:SLC43A1
gene id: 9541:SLC43A1
uniprot id: A0A2K5WV66
names: Subcellular Location Annotation
messages: Membrane

9541:GRIN2C
gene id: 9541:GRIN2C
uniprot id: A0A2K5VRU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:RNASE6
gene id: 9541:RNASE6
uniprot id: A0A2K5UCI8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:VDR
gene id: 9541:VDR
uniprot id: A0A2K5WLL6
uniprot id: G7PHP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:LOC102118453
gene id: 9541:LOC102118453
uniprot id: A0A2K5UIT2
names: Similarity
messages: Belongs to the SPT20 family.

9541:FOXG1
gene id: 9541:FOXG1
uniprot id: A0A2K5X839
names: Subcellular Location Annotation
messages: Nucleus

9541:ANTXR1
gene id: 9541:ANTXR1
uniprot id: A0A2K5VJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9541:TUBG2
gene id: 9541:TUBG2
uniprot id: I7GKF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9541:C12H2orf88
gene id: 9541:C12H2orf88
uniprot id: A0A7N9CPM8
uniprot id: A0A8J8XQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9541:PANX3
gene id: 9541:PANX3
uniprot id: A0A2K5VA54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9541:CD28
gene id: 9541:CD28
uniprot id: A0A2K5WCD2
uniprot id: Q0PDN3
names: Subcellular Location Annotation
messages: Membrane

9541:XRN2
gene id: 9541:XRN2
uniprot id: A0A2K5WKV6
uniprot id: A0A8J8YIF4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9541:ATP6AP1
gene id: 9541:ATP6AP1
uniprot id: A0A2K5WAU6
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9541:ATP1B3
gene id: 9541:ATP1B3
uniprot id: I7G806
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:HBP1
gene id: 9541:HBP1
uniprot id: A0A2K5UPY9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9541:PDE8A
gene id: 9541:PDE8A
uniprot id: A0A2K5VH55
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:RNASE1
gene id: 9541:RNASE1
uniprot id: A0A8J8XAJ9
uniprot id: G7P9M4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:LDLRAD3
gene id: 9541:LDLRAD3
uniprot id: A0A2K5VEJ9
uniprot id: A0A7N9C7V6
uniprot id: I7GJY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:UBE2E3
gene id: 9541:UBE2E3
uniprot id: I7G5F9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:AXIN1
gene id: 9541:AXIN1
uniprot id: A0A2K5TYD6
uniprot id: A0A2K5TYE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9541:AVPR1A
gene id: 9541:AVPR1A
uniprot id: E3V2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9541:IQSEC1
gene id: 9541:IQSEC1
uniprot id: A0A2K5VJG9
names: Similarity
messages: Belongs to the BRAG family.

9541:ZNF213
gene id: 9541:ZNF213
uniprot id: A0A2K5V2G0
names: Subcellular Location Annotation
messages: Nucleus

9541:FAT2
gene id: 9541:FAT2
uniprot id: A0A2K5WXC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GNA12
gene id: 9541:GNA12
uniprot id: I7GI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9541:ANKRD13C
gene id: 9541:ANKRD13C
uniprot id: A0A2K5TT21
names: Subcellular Location Annotation
messages: Membrane

9541:DOCK11
gene id: 9541:DOCK11
uniprot id: A0A2K5X7R3
uniprot id: A0A2K5X856
names: Similarity
messages: Belongs to the DOCK family.

9541:NIF3L1
gene id: 9541:NIF3L1
uniprot id: A0A7N9CS85
uniprot id: A0A7N9DDN3
uniprot id: A0A8J8XNX5
uniprot id: G7PL60
uniprot id: I7GHS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9541:LOC102143668
gene id: 9541:LOC102143668
uniprot id: A0A2K5V7C3
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9541:LOC123566751
gene id: 9541:LOC123566751
uniprot id: A0A2K5TUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9541:NDUFB4
gene id: 9541:NDUFB4
uniprot id: A0A2K5U416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:ALAS1
gene id: 9541:ALAS1
uniprot id: A0A2K5WGP3
uniprot id: Q4R6D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9541:TMEM43
gene id: 9541:TMEM43
uniprot id: A0A7N9I9H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9541:C19H19orf54
gene id: 9541:C19H19orf54
uniprot id: A0A2K5W917
uniprot id: A0A7N9CGI7
names: Similarity
messages: Belongs to the UPF0692 family.

9541:MOB2
gene id: 9541:MOB2
uniprot id: A0A2K5V7E2
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:GNAT3
gene id: 9541:GNAT3
uniprot id: A0A2K5U8X8
uniprot id: A0A8J8XRP4
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:CTPS1
gene id: 9541:CTPS1
uniprot id: A0A2K5X3G0
uniprot id: G7NUE2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9541:OSBPL9
gene id: 9541:OSBPL9
uniprot id: A0A2K5VIC3
uniprot id: A0A2K5VII1
uniprot id: A0A2K5VIN8
names: Similarity
messages: Belongs to the OSBP family.

9541:HTR1B
gene id: 9541:HTR1B
uniprot id: G7P3H1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9541:EPHA5
gene id: 9541:EPHA5
uniprot id: A0A2K5W6J5
uniprot id: A0A2K5W6J6
uniprot id: A0A2K5W6M9
uniprot id: A0A7N9D0P2
names: Subcellular Location Annotation
messages: Membrane

9541:TRIM32
gene id: 9541:TRIM32
uniprot id: A0A8J8YEP3
uniprot id: G7PRK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9541:MMP8
gene id: 9541:MMP8
uniprot id: A0A2K5V406
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:GK2
gene id: 9541:GK2
uniprot id: Q4R4D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm
messages: Interacts with ARMC12 and PLD6.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (By similarity).
messages: Mitochondrion outer membrane

9541:DUSP29
gene id: 9541:DUSP29
uniprot id: A0A2K5TMM7
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9541:TUB
gene id: 9541:TUB
uniprot id: A0A2K5UYI9
uniprot id: A0A2K5UYJ4
uniprot id: A0A2K5UYM7
uniprot id: G7PQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9541:CSMD2
gene id: 9541:CSMD2
uniprot id: A0A2K5VGA3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SCGN
gene id: 9541:SCGN
uniprot id: A0A8J8YES1
uniprot id: G7P4K7
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9541:UBE2D4
gene id: 9541:UBE2D4
uniprot id: A0A7N9CTY0
uniprot id: A0A7N9D203
uniprot id: A0A7N9D2F9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:SERPINF2
gene id: 9541:SERPINF2
uniprot id: A0A2K5WNU6
names: Similarity
messages: Belongs to the serpin family.

9541:ARFGEF2
gene id: 9541:ARFGEF2
uniprot id: A0A2K5TVR7
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9541:DNAJA1
gene id: 9541:DNAJA1
uniprot id: Q4R6Z9
names: Subcellular Location Annotation
messages: Membrane

9541:D2HGDH
gene id: 9541:D2HGDH
uniprot id: A0A7N9ICP3
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9541:CGA
gene id: 9541:CGA
uniprot id: G7P3J5
uniprot id: Q9BEH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9541:TGS1
gene id: 9541:TGS1
uniprot id: A0A2K5UN56
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9541:RAB3D
gene id: 9541:RAB3D
uniprot id: A0A2K5TXE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9541:KRTCAP3
gene id: 9541:KRTCAP3
uniprot id: A0A2K5TVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9541:SH3GL2
gene id: 9541:SH3GL2
uniprot id: A0A2K5VIB0
uniprot id: A0A7N9CLV0
uniprot id: A0A7N9D207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9541:SMG9
gene id: 9541:SMG9
uniprot id: A0A2K5X1U7
names: Similarity
messages: Belongs to the SMG9 family.

9541:RAD1
gene id: 9541:RAD1
uniprot id: A0A2K5UF89
uniprot id: A0A7N9D9C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9541:RALA
gene id: 9541:RALA
uniprot id: A0A2K5TV78
uniprot id: G8F2X3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9541:TPP1
gene id: 9541:TPP1
uniprot id: Q4R4L8
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Melanosome

9541:LIG3
gene id: 9541:LIG3
uniprot id: A0A2K5VCB2
uniprot id: A0A2K5VCG8
uniprot id: G7PU29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9541:DCLRE1A
gene id: 9541:DCLRE1A
uniprot id: A0A2K5TQZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9541:DEFB114
gene id: 9541:DEFB114
uniprot id: A0A2K5X4F6
uniprot id: G7P4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:ARF1
gene id: 9541:ARF1
uniprot id: A0A158SIP9
uniprot id: Q4R5P2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form. Intrinsic GTPase activity is almost undetectable in vitro. Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1. Interacts with C9orf72.
messages: Postsynaptic density
messages: Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity).
messages: synaptosome

9541:ERG
gene id: 9541:ERG
uniprot id: A0A2K5UZL3
uniprot id: A0A2K5UZM9
uniprot id: A0A2K5UZT5
uniprot id: A0A2K5UZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:BCAP31
gene id: 9541:BCAP31
uniprot id: A0A2K5WYG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9541:C6H5orf24
gene id: 9541:C6H5orf24
uniprot id: G7P8B2
names: Similarity
messages: Belongs to the UPF0461 family.

9541:CSTF2T
gene id: 9541:CSTF2T
uniprot id: G8F2J6
names: Subcellular Location Annotation
messages: Nucleus

9541:ASB7
gene id: 9541:ASB7
uniprot id: A0A8J8YNA7
uniprot id: G7P9J5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:MTMR3
gene id: 9541:MTMR3
uniprot id: A0A2K5WF20
uniprot id: A0A2K5WF31
uniprot id: A0A2K5WF62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9541:TFCP2
gene id: 9541:TFCP2
uniprot id: A0A2K5TXR1
uniprot id: A0A7N9IEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9541:GTF2H4
gene id: 9541:GTF2H4
uniprot id: A0A2K5UIY7
uniprot id: A0A8J8YN01
uniprot id: G7P4M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9541:GCNT2
gene id: 9541:GCNT2
uniprot id: A0A7N9CM24
uniprot id: A0A8J8Y4A2
uniprot id: G7P4D9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:PSMA2
gene id: 9541:PSMA2
uniprot id: Q4R6R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:MPDZ
gene id: 9541:MPDZ
uniprot id: A0A2K5V3R8
uniprot id: A0A2K5V3V7
names: Subcellular Location Annotation
messages: tight junction

9541:LOC102126768
gene id: 9541:LOC102126768
uniprot id: A0A2K5VSN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9541:DHX9
gene id: 9541:DHX9
uniprot id: A0A2K5WUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9541:DAW1
gene id: 9541:DAW1
uniprot id: Q4R8E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR69 family.
messages: May play a role in axonemal outer row dynein assembly.
messages: cilium

9541:LSM12
gene id: 9541:LSM12
uniprot id: A0A2K5UVE5
names: Similarity
messages: Belongs to the LSM12 family.

9541:EDIL3
gene id: 9541:EDIL3
uniprot id: A0A2K5WYU3
uniprot id: A0A2K5WYU7
uniprot id: A0A2K5WYV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PRPSAP1
gene id: 9541:PRPSAP1
uniprot id: A0A7N9DCF7
uniprot id: A0A7N9IDC8
uniprot id: Q4R428
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9541:SERBP1
gene id: 9541:SERBP1
uniprot id: A0A2K5X0G7
uniprot id: A0A2K5X0J0
uniprot id: A0A7N9CX01
uniprot id: Q4R9B2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:ASB4
gene id: 9541:ASB4
uniprot id: A0A2K5VVR7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:HEXIM2
gene id: 9541:HEXIM2
uniprot id: A0A8J8YBN7
uniprot id: G7PV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9541:EXOC3L2
gene id: 9541:EXOC3L2
uniprot id: A0A2K5UL86
names: Similarity
messages: Belongs to the SEC6 family.

9541:NOVA1
gene id: 9541:NOVA1
uniprot id: Q2PFW9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord.
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus
messages: The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain.

9541:TSPAN1
gene id: 9541:TSPAN1
uniprot id: G7NV03
uniprot id: Q4R7W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lysosome membrane
messages: Membrane

9541:POLB
gene id: 9541:POLB
uniprot id: Q2PFM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9541:SULT2B1
gene id: 9541:SULT2B1
uniprot id: A0A8J8YDJ6
uniprot id: G7PY24
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:GNAS
gene id: 9541:GNAS
uniprot id: Q2PFZ8
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9541:CIAO2B
gene id: 9541:CIAO2B
uniprot id: A0A2K5TVX0
names: Similarity
messages: Belongs to the MIP18 family.

9541:SLC29A1
gene id: 9541:SLC29A1
uniprot id: A0A2K5WL78
uniprot id: G7P406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9541:LANCL2
gene id: 9541:LANCL2
uniprot id: A0A2K5VSB6
uniprot id: A0A7N9D691
names: Similarity
messages: Belongs to the LanC-like protein family.

9541:LOC102140552
gene id: 9541:LOC102140552
uniprot id: A0A2K5UFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9541:SLC2A5
gene id: 9541:SLC2A5
uniprot id: A0A2K5UZD6
uniprot id: A0A7N9IEN2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: sarcolemma

9541:LOC102142483
gene id: 9541:LOC102142483
uniprot id: A0A2K5TZR0
uniprot id: A0A7N9I9J5
names: Similarity
messages: Belongs to the GAGE family.

9541:PARG
gene id: 9541:PARG
uniprot id: A0A2K5VGN9
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9541:PSME3
gene id: 9541:PSME3
uniprot id: A0A2K5WT28
uniprot id: Q4R4V3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).
messages: Belongs to the PA28 family.
messages: Cytoplasm
messages: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53, MDM2 and MAP3K3. Associates with the proteasome. Interacts with CCAR2. Interacts with PSME3IP1 (via C-terminus); the interaction is direct and promotes the association of PSME3 with the 20S proteasome. Interacts with COIL; the interaction is inhibited by PSME3IP1.
messages: Nucleus
messages: Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2.
messages: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity).
messages: The C-terminal sequences affect heptamer stability and proteasome affinity.

9541:CHD3
gene id: 9541:CHD3
uniprot id: A0A2K5UJJ5
uniprot id: A0A2K5UJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9541:SLC7A11
gene id: 9541:SLC7A11
uniprot id: A0A8J8XHH6
uniprot id: G7P6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9541:UBE2S
gene id: 9541:UBE2S
uniprot id: A0A2K5U991
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:KEG98 p07
gene id: 9541:KEG98_p07
uniprot id: C3W4Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

9541:TLR8
gene id: 9541:TLR8
uniprot id: A0A2K5TZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9541:ZEB2
gene id: 9541:ZEB2
uniprot id: A0A2K5URR5
uniprot id: A0A2K5URS4
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9541:PPP3CC
gene id: 9541:PPP3CC
uniprot id: A0A2K5UDC3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9541:PLA2G3
gene id: 9541:PLA2G3
uniprot id: A0A2K5USI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9541:LOC102123220
gene id: 9541:LOC102123220
uniprot id: Q4R784
names: Similarity
messages: Belongs to the perilipin family.

9541:POLR1E
gene id: 9541:POLR1E
uniprot id: A0A2K5VTT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9541:DPM3
gene id: 9541:DPM3
uniprot id: G7NV63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9541:TFAP2C
gene id: 9541:TFAP2C
uniprot id: A0A2K5WDE8
uniprot id: A0A2K5WDG7
names: Similarity
messages: Belongs to the AP-2 family.

9541:HEBP1
gene id: 9541:HEBP1
uniprot id: A0A8J8YGT6
uniprot id: G7PJW7
names: Similarity
messages: Belongs to the HEBP family.

9541:HMGN4
gene id: 9541:HMGN4
uniprot id: A0A7N9CUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:CYRIA
gene id: 9541:CYRIA
uniprot id: A0A8J8XXW2
uniprot id: G7PLN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9541:DCST1
gene id: 9541:DCST1
uniprot id: A0A2K5V0Q0
names: Subcellular Location Annotation
messages: Membrane

9541:CRYAB
gene id: 9541:CRYAB
uniprot id: G7PNS7
uniprot id: Q60HG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).
messages: Lysosome
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
messages: Nucleus
messages: Secreted

9541:UBA52
gene id: 9541:UBA52
uniprot id: P0C273
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9541:CYP4F2
gene id: 9541:CYP4F2
uniprot id: A8CBR4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:LOC102117721
gene id: 9541:LOC102117721
uniprot id: G7P2L6
uniprot id: G7P2M7
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SPDEF
gene id: 9541:SPDEF
uniprot id: A0A8J8XPV0
uniprot id: G7P2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:CAP2
gene id: 9541:CAP2
uniprot id: A0A2K5VWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9541:DNASE2B
gene id: 9541:DNASE2B
uniprot id: I7GM04
names: Similarity
messages: Belongs to the DNase II family.

9541:HMX3
gene id: 9541:HMX3
uniprot id: A0A2K5WVH9
names: Subcellular Location Annotation
messages: Nucleus

9541:RRN3
gene id: 9541:RRN3
uniprot id: A0A2K5U608
names: Similarity
messages: Belongs to the RRN3 family.

9541:TSR2
gene id: 9541:TSR2
uniprot id: A0A2K5U792
uniprot id: A0A7N9CWW3
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9541:RGS8
gene id: 9541:RGS8
uniprot id: A0A2K5VA48
uniprot id: A0A2K5VA51
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9541:IL36A
gene id: 9541:IL36A
uniprot id: A0A2K5UTG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:RNF152
gene id: 9541:RNF152
uniprot id: A0A8J8YFA8
uniprot id: G7PWW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9541:MAN1B1
gene id: 9541:MAN1B1
uniprot id: A0A2K5W1J4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:CDH19
gene id: 9541:CDH19
uniprot id: A0A2K5UEG2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:ATP6V1G3
gene id: 9541:ATP6V1G3
uniprot id: A0A2K5WMY6
uniprot id: G7NWH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:CEP55
gene id: 9541:CEP55
uniprot id: A0A2K5WVH8
names: Subcellular Location Annotation
messages: Cytoplasm

9541:TRIM45
gene id: 9541:TRIM45
uniprot id: A0A2K5X306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9541:FNTA
gene id: 9541:FNTA
uniprot id: A0A2K5V989
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9541:ATG7
gene id: 9541:ATG7
uniprot id: A0A8J8Y178
uniprot id: G7NYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9541:C6
gene id: 9541:C6
uniprot id: A0A2K5W3S5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:MUSK
gene id: 9541:MUSK
uniprot id: A0A2K5USF6
uniprot id: A0A2K5USG2
uniprot id: A0A2K5USG5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ATP5F1A
gene id: 9541:ATP5F1A
uniprot id: A0A2K5TVD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9541:ARPIN
gene id: 9541:ARPIN
uniprot id: A0A2K5VUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

9541:TRAPPC6A
gene id: 9541:TRAPPC6A
uniprot id: A0A2K5WBX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9541:C8B
gene id: 9541:C8B
uniprot id: A0A2K5TJ42
uniprot id: G8F445
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:SRP19
gene id: 9541:SRP19
uniprot id: A0A2K5TPZ6
uniprot id: A0A2K5TPZ7
uniprot id: A0A7N9CAU8
uniprot id: G8F2L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9541:HDAC3
gene id: 9541:HDAC3
uniprot id: A0A2K5U0C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9541:PAM
gene id: 9541:PAM
uniprot id: A0A2K5U511
uniprot id: A0A2K5U515
uniprot id: A0A2K5U526
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9541:PPP1R35
gene id: 9541:PPP1R35
uniprot id: A0A2K5WZC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9541:CDC25C
gene id: 9541:CDC25C
uniprot id: A0A2K5V9Q2
uniprot id: Q4R6H0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9541:KCNMA1
gene id: 9541:KCNMA1
uniprot id: A0A2K5VSK6
uniprot id: A0A2K5VSL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

9541:TMPO
gene id: 9541:TMPO
uniprot id: A0A2K5WJG4
uniprot id: A0A2K5WJJ6
uniprot id: A0A2K5WJJ9
uniprot id: A0A7N9DAL4
names: Similarity
messages: Belongs to the LEM family.

9541:FUT9
gene id: 9541:FUT9
uniprot id: A0A8J8XZV7
uniprot id: G7P425
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9541:TBCC
gene id: 9541:TBCC
uniprot id: A0A2K5W8E9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9541:LMX1B
gene id: 9541:LMX1B
uniprot id: A0A2K5TQ26
names: Subcellular Location Annotation
messages: Nucleus

9541:S100A8
gene id: 9541:S100A8
uniprot id: A0A2K5X560
names: Similarity
messages: Belongs to the S-100 family.

9541:RNPS1
gene id: 9541:RNPS1
uniprot id: A0A2K5VYG9
uniprot id: G7Q091
uniprot id: Q4R5N1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Cytoplasm
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10 (By similarity).
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus
messages: Nucleus speckle
messages: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).
messages: Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro (By similarity).
messages: The RRM domain is required for the formation of the ASAP complex.

9541:SNRPD3
gene id: 9541:SNRPD3
uniprot id: A0A7N9I9G4
uniprot id: G7PHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9541:MGAT5
gene id: 9541:MGAT5
uniprot id: A0A8J8XC29
uniprot id: G7PN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9541:ARL8A
gene id: 9541:ARL8A
uniprot id: A0A2K5UB31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9541:LMBRD1
gene id: 9541:LMBRD1
uniprot id: Q4R5E3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Interacts with ABCD4; this interaction induces the translocation of ABCD4 from the endoplasmic reticulum to the lysosome. Interacts with ABCD4 and MMACHC; this interaction ensures the transport of cobalamin from the lysosome to the cytoplasm (By similarity). Interacts with INSR, adapter protein complex 2 and clathrin heavy chain (By similarity).
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal transporter ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).
messages: Lysosome membrane
messages: N-glycosylated.
messages: clathrin-coated vesicle

9541:ADORA2B
gene id: 9541:ADORA2B
uniprot id: A0A2K5UDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9541:SLC10A1
gene id: 9541:SLC10A1
uniprot id: A2V9Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9541:LOC102133117
gene id: 9541:LOC102133117
uniprot id: A0A7N9D7R8
names: Similarity
messages: Belongs to the histone H3 family.

9541:TMEM178B
gene id: 9541:TMEM178B
uniprot id: A0A2K5VJF5
names: Similarity
messages: Belongs to the TMEM178 family.

9541:ZFP36L1
gene id: 9541:ZFP36L1
uniprot id: I7GKC6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9541:GRK6
gene id: 9541:GRK6
uniprot id: A0A2K5WTN2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:GDPD3
gene id: 9541:GDPD3
uniprot id: A0A2K5UUN2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:LOC102119667
gene id: 9541:LOC102119667
uniprot id: A0A2K5TQN8
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9541:ATP10A
gene id: 9541:ATP10A
uniprot id: A0A2K5WLS9
names: Subcellular Location Annotation
messages: Membrane

9541:TM4SF5
gene id: 9541:TM4SF5
uniprot id: A0A2K5WL12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9541:ME3
gene id: 9541:ME3
uniprot id: I7GL37
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9541:CPT1A
gene id: 9541:CPT1A
uniprot id: A0A2K5UZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:LOC102120366
gene id: 9541:LOC102120366
uniprot id: A0A2K5UBY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:FH
gene id: 9541:FH
uniprot id: I7GLU3
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9541:CAPZA2
gene id: 9541:CAPZA2
uniprot id: Q4R5G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9541:CRISP3
gene id: 9541:CRISP3
uniprot id: A0A2K5W4E5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:VWF
gene id: 9541:VWF
uniprot id: A0A2K5X4G5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9541:UROD
gene id: 9541:UROD
uniprot id: A0A2K5V2R0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9541:CDC37L1
gene id: 9541:CDC37L1
uniprot id: G7PSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9541:FOXJ3
gene id: 9541:FOXJ3
uniprot id: A0A2K5WH51
uniprot id: A0A2K5WHE4
names: Subcellular Location Annotation
messages: Nucleus

9541:SPIRE1
gene id: 9541:SPIRE1
uniprot id: A0A2K5TW43
uniprot id: A0A2K5TW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9541:TSN
gene id: 9541:TSN
uniprot id: A0A2K5VL45
uniprot id: A0A2K5VL61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9541:FGFR1
gene id: 9541:FGFR1
uniprot id: A0A2K5WIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9541:PRKACB
gene id: 9541:PRKACB
uniprot id: A0A2K5VK60
uniprot id: A0A2K5VKF1
uniprot id: A0A2K5VKF2
uniprot id: A0A2K5VKH9
uniprot id: A0A2K5VKP3
uniprot id: G7NX32
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9541:RTCB
gene id: 9541:RTCB
uniprot id: G7PF98
uniprot id: Q4R6X4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Nucleus

9541:TRIM46
gene id: 9541:TRIM46
uniprot id: A0A2K5TMA3
uniprot id: G8F697
names: Subcellular Location Annotation
messages: cytoskeleton

9541:CCK
gene id: 9541:CCK
uniprot id: I7GJF3
uniprot id: P23362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gastrin/cholecystokinin family.
messages: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.
messages: Secreted
messages: The precursor is cleaved by ACE, which removes the Gly-Arg-Arg peptide at the C-terminus, leading to mature hormone.
messages: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
messages: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

9541:GPBP1L1
gene id: 9541:GPBP1L1
uniprot id: A0A2K5TSE3
uniprot id: G8F2B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9541:BLOC1S2
gene id: 9541:BLOC1S2
uniprot id: A0A2K5U1Y3
uniprot id: A0A2K5U220
uniprot id: Q4R7C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S2 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts with gamma-tubulin. Interacts with IFT57.
messages: Lysosome membrane
messages: centrosome

9541:C18H18orf32
gene id: 9541:C18H18orf32
uniprot id: I7G4M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9541:KPNA4
gene id: 9541:KPNA4
uniprot id: A0A2K5WX73
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:AK4
gene id: 9541:AK4
uniprot id: A0A2K5UMF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9541:DYRK1A
gene id: 9541:DYRK1A
uniprot id: A0A2K5VA44
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9541:CNR2
gene id: 9541:CNR2
uniprot id: A0A8J8XAP5
uniprot id: G7NVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:P2RX3
gene id: 9541:P2RX3
uniprot id: A0A8J8XY24
uniprot id: G7PQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9541:GREB1L
gene id: 9541:GREB1L
uniprot id: A0A2K5W577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

9541:NPPB
gene id: 9541:NPPB
uniprot id: A0A2K5V0K8
uniprot id: G8F4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9541:PHACTR2
gene id: 9541:PHACTR2
uniprot id: A0A2K5UGF4
uniprot id: A0A2K5UGH5
uniprot id: A0A2K5UGL9
uniprot id: A0A2K5UGM6
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9541:CRYL1
gene id: 9541:CRYL1
uniprot id: A0A2K5WFB8
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9541:MTFP1
gene id: 9541:MTFP1
uniprot id: A0A8J8YHQ5
uniprot id: G7PF69
names: Similarity
messages: Belongs to the MTFP1 family.

9541:SPRN
gene id: 9541:SPRN
uniprot id: A0A2K5UMX7
names: Function
names: Similarity
messages: Belongs to the SPRN family.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

9541:NOB1
gene id: 9541:NOB1
uniprot id: Q4R537
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOB1 family.
messages: May interact with UPF2 (By similarity). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (By similarity).
messages: May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
messages: Nucleus

9541:ACSM1
gene id: 9541:ACSM1
uniprot id: G7Q0M8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:DGKZ
gene id: 9541:DGKZ
uniprot id: A0A2K5V5H0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9541:SLC35E1
gene id: 9541:SLC35E1
uniprot id: G7PZQ9
names: Subcellular Location Annotation
messages: Membrane

9541:CNDP2
gene id: 9541:CNDP2
uniprot id: A0A2K5WQW4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9541:PDE4D
gene id: 9541:PDE4D
uniprot id: A0A2K5VWF6
uniprot id: A0A2K5VWG8
uniprot id: A0A2K5VWJ8
uniprot id: A0A2K5VWK7
uniprot id: A0A2K5VWK9
uniprot id: A0A2K5VWL9
uniprot id: A0A2K5VWR4
uniprot id: A0A7N9D392
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:RPS21
gene id: 9541:RPS21
uniprot id: A0A2K5U026
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9541:LARS2
gene id: 9541:LARS2
uniprot id: A0A2K5W8T1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:MEN1
gene id: 9541:MEN1
uniprot id: A0A2K5U2P9
uniprot id: G7PPQ8
names: Subcellular Location Annotation
messages: Nucleus

9541:RARS1
gene id: 9541:RARS1
uniprot id: A0A8J8XGN1
uniprot id: G7P6U6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:NDUFAB1
gene id: 9541:NDUFAB1
uniprot id: I7GLC6
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9541:PDGFC
gene id: 9541:PDGFC
uniprot id: A0A2K5V0S6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ACOT2
gene id: 9541:ACOT2
uniprot id: A0A2K5UWS0
uniprot id: I7GIT8
uniprot id: Q4R4J8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9541:SLC7A8
gene id: 9541:SLC7A8
uniprot id: A0A2K5U9B8
uniprot id: A0A8J8YCV3
uniprot id: G7P9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9541:LRRC8A
gene id: 9541:LRRC8A
uniprot id: A0A2K5VRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:SLC5A9
gene id: 9541:SLC5A9
uniprot id: A0A2K5WU11
uniprot id: A0A2K5WU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9541:RRP1B
gene id: 9541:RRP1B
uniprot id: A0A2K5X2F9
names: Similarity
messages: Belongs to the RRP1 family.

9541:LOC102145420
gene id: 9541:LOC102145420
uniprot id: A0A7N9D6B8
uniprot id: A0A8J8YFM8
uniprot id: G7PLA8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:GIMAP4
gene id: 9541:GIMAP4
uniprot id: A0A2K5U9G2
uniprot id: I7GJF8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9541:LOC102144433
gene id: 9541:LOC102144433
uniprot id: A0A2K5TP58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:STARD8
gene id: 9541:STARD8
uniprot id: A0A2K5WSY2
names: Subcellular Location Annotation
messages: Cytoplasm

9541:LOC102144463
gene id: 9541:LOC102144463
uniprot id: A0A2K5WD85
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9541:ATP5PF
gene id: 9541:ATP5PF
uniprot id: Q8SPH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9541:GGCX
gene id: 9541:GGCX
uniprot id: A0A8J8XEH1
uniprot id: G7PMM1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9541:CTNNA3
gene id: 9541:CTNNA3
uniprot id: A0A2K5W256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: cytoskeleton

9541:KCTD10
gene id: 9541:KCTD10
uniprot id: A0A2K5U754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9541:NR6A1
gene id: 9541:NR6A1
uniprot id: A0A2K5VTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:RHPN1
gene id: 9541:RHPN1
uniprot id: A0A2K5V419
names: Similarity
messages: Belongs to the RHPN family.

9541:KPNA6
gene id: 9541:KPNA6
uniprot id: A0A2K5X9F2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:NDUFA13
gene id: 9541:NDUFA13
uniprot id: Q4R6H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.
messages: Mitochondrion inner membrane
messages: Nucleus

9541:LLPH
gene id: 9541:LLPH
uniprot id: A0A2K5X0J3
names: Similarity
messages: Belongs to the learning-associated protein family.

9541:UPP1
gene id: 9541:UPP1
uniprot id: A0A2K5W8D7
uniprot id: A0A8J8XDU8
uniprot id: G7P1S6
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9541:PDCL3
gene id: 9541:PDCL3
uniprot id: A0A2K5TXR2
names: Similarity
messages: Belongs to the phosducin family.

9541:ADGRG2
gene id: 9541:ADGRG2
uniprot id: A0A2K5TTP0
uniprot id: A0A2K5TTP6
names: Subcellular Location Annotation
messages: Membrane

9541:ENTR1
gene id: 9541:ENTR1
uniprot id: A0A2K5TNU6
names: Similarity
messages: Belongs to the ENTR1 family.

9541:STARD5
gene id: 9541:STARD5
uniprot id: A0A2K5UV30
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9541:SPOCK3
gene id: 9541:SPOCK3
uniprot id: A0A2K5X517
uniprot id: A0A2K5X528
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PAPOLG
gene id: 9541:PAPOLG
uniprot id: A0A2K5W0K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9541:VPS35
gene id: 9541:VPS35
uniprot id: A0A2K5WXA3
uniprot id: A0A2K5WXX7
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9541:LNPK
gene id: 9541:LNPK
uniprot id: A0A2K5TXW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9541:ZDHHC17
gene id: 9541:ZDHHC17
uniprot id: A0A2K5VZT6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CNNM4
gene id: 9541:CNNM4
uniprot id: A0A2K5V329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9541:PAX5
gene id: 9541:PAX5
uniprot id: A0A2K5VLQ1
uniprot id: A0A2K5VM65
uniprot id: G7PRX3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:NDFIP2
gene id: 9541:NDFIP2
uniprot id: A0A2K5WAN9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9541:SFXN1
gene id: 9541:SFXN1
uniprot id: A0A2K5U2P2
uniprot id: A0A8J8XHZ4
uniprot id: G7P6Y2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9541:HEXIM1
gene id: 9541:HEXIM1
uniprot id: A0A8J8YQK1
uniprot id: G7PV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9541:MCF2L
gene id: 9541:MCF2L
uniprot id: A0A2K5UTV6
uniprot id: A0A2K5UU46
uniprot id: A0A2K5UU51
names: Subcellular Location Annotation
messages: Cytoplasm

9541:TEX261
gene id: 9541:TEX261
uniprot id: A0A2K5VWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9541:RPS2
gene id: 9541:RPS2
uniprot id: A0A2K5W6W4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

9541:TELO2
gene id: 9541:TELO2
uniprot id: A0A2K5W515
names: Similarity
messages: Belongs to the TEL2 family.

9541:ASZ1
gene id: 9541:ASZ1
uniprot id: A0A2K5U3L9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9541:GDF5
gene id: 9541:GDF5
uniprot id: A0A2K5W4R5
names: Similarity
messages: Belongs to the TGF-beta family.

9541:EIF3E
gene id: 9541:EIF3E
uniprot id: A0A2K5X1X1
uniprot id: Q4R6G8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9541:NFIB
gene id: 9541:NFIB
uniprot id: A0A2K5W5D7
uniprot id: A0A2K5W5F4
uniprot id: G7PSC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9541:PTH1R
gene id: 9541:PTH1R
uniprot id: A0A2K5V724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9541:BRF1
gene id: 9541:BRF1
uniprot id: A0A2K5U738
uniprot id: A0A2K5U741
names: Similarity
messages: Belongs to the TFIIB family.

9541:AGXT
gene id: 9541:AGXT
uniprot id: A0A2K5VWZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9541:LOC102146578
gene id: 9541:LOC102146578
uniprot id: A0A2K5UX20
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9541:LOC102146577
gene id: 9541:LOC102146577
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:ATP2C1
gene id: 9541:ATP2C1
uniprot id: A0A2K5X252
uniprot id: A0A2K5X263
uniprot id: A0A2K5X271
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9541:SEPTIN5
gene id: 9541:SEPTIN5
uniprot id: A0A2K5WKW4
uniprot id: A0A2K5WKW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cytoskeleton

9541:NEUROD6
gene id: 9541:NEUROD6
uniprot id: G7P0G5
uniprot id: Q4R5G6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9541:ADAM8
gene id: 9541:ADAM8
uniprot id: A0A2K5VED6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ATXN2L
gene id: 9541:ATXN2L
uniprot id: A0A2K5UTW7
names: Similarity
messages: Belongs to the ataxin-2 family.

9541:TAF1B
gene id: 9541:TAF1B
uniprot id: Q4R657
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity).
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity).
messages: Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, notably composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3 (By similarity).
messages: nucleolus

9541:MATK
gene id: 9541:MATK
uniprot id: A0A2K5UQL7
uniprot id: A0A2K5UQS4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:LOC102122931
gene id: 9541:LOC102122931
uniprot id: A0A7N9D2E9
names: Subcellular Location Annotation
messages: Membrane

9541:ACAA1
gene id: 9541:ACAA1
uniprot id: Q2PG05
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9541:GAB2
gene id: 9541:GAB2
uniprot id: A0A2K5WAB8
names: Similarity
messages: Belongs to the GAB family.

9541:SMS
gene id: 9541:SMS
uniprot id: A0A2K5U1T0
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9541:SOD2
gene id: 9541:SOD2
uniprot id: Q8HXP3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

9541:AMOT
gene id: 9541:AMOT
uniprot id: A0A2K5V135
names: Similarity
messages: Belongs to the angiomotin family.

9541:FGF11
gene id: 9541:FGF11
uniprot id: A0A2K5W996
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:SLC22A2
gene id: 9541:SLC22A2
uniprot id: A0A2K5UY99
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9541:EMC9
gene id: 9541:EMC9
uniprot id: A0A2K5W141
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9541:KCNH1
gene id: 9541:KCNH1
uniprot id: A0A2K5TQ71
names: Subcellular Location Annotation
messages: Membrane

9541:TP53INP1
gene id: 9541:TP53INP1
uniprot id: A0A2K5V686
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9541:DLGAP2
gene id: 9541:DLGAP2
uniprot id: A0A2K5X1M8
names: Similarity
messages: Belongs to the SAPAP family.

9541:CSMD3
gene id: 9541:CSMD3
uniprot id: A0A2K5V697
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SRMS
gene id: 9541:SRMS
uniprot id: A0A2K5TQL8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:PUS7
gene id: 9541:PUS7
uniprot id: A0A2K5WSQ6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9541:IL18R1
gene id: 9541:IL18R1
uniprot id: A0A2K5V3J9
uniprot id: A0A2K5V3M1
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:TMEM38B
gene id: 9541:TMEM38B
uniprot id: A0A2K5X7D5
uniprot id: A0A7N9CP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9541:CALB1
gene id: 9541:CALB1
uniprot id: G7PC68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9541:PLSCR3
gene id: 9541:PLSCR3
uniprot id: A0A2K5X0T4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9541:SCAMP3
gene id: 9541:SCAMP3
uniprot id: A0A2K5V3C2
uniprot id: A0A2K5V3F8
uniprot id: G8F6B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9541:PAQR6
gene id: 9541:PAQR6
uniprot id: A0A2K5VFH4
uniprot id: A0A2K5VFH9
uniprot id: A0A7N9CSG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:YWHAH
gene id: 9541:YWHAH
uniprot id: Q4R5L9
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:CAPN2
gene id: 9541:CAPN2
uniprot id: Q9GLG1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 7 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3.

9541:C7
gene id: 9541:C7
uniprot id: A0A2K5W920
uniprot id: A0A7N9IA03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:C15H9orf24
gene id: 9541:C15H9orf24
uniprot id: Q95LU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMRP1 family.
messages: Cytoplasm
messages: Interacts with alpha-tubulin.
messages: May play a role in spermatogenesis. May be involved in differentiation or function of ciliated cells (By similarity).
messages: Nucleus
messages: cytoskeleton

9541:CEMIP2
gene id: 9541:CEMIP2
uniprot id: A0A2K5W3E0
uniprot id: A0A2K5W3F2
names: Similarity
messages: Belongs to the CEMIP family.

9541:LOC107126403
gene id: 9541:LOC107126403
uniprot id: A0A2K5X0X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9541:FAM149B1
gene id: 9541:FAM149B1
uniprot id: A0A2K5WD96
names: Similarity
messages: Belongs to the FAM149 family.

9541:DCPS
gene id: 9541:DCPS
uniprot id: A0A7N9CFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9541:GALR2
gene id: 9541:GALR2
uniprot id: A0A2K5WWW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:B4GAT1
gene id: 9541:B4GAT1
uniprot id: Q4R5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:EIF2B4
gene id: 9541:EIF2B4
uniprot id: A0A2K5VM05
uniprot id: A0A7N9CP23
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9541:LOC102123561
gene id: 9541:LOC102123561
uniprot id: A0A2K5UNU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ANK3
gene id: 9541:ANK3
uniprot id: A0A2K5VDJ8
uniprot id: A0A2K5VDM2
uniprot id: A0A2K5VE75
names: Subcellular Location Annotation
messages: Membrane

9541:PPP2R5C
gene id: 9541:PPP2R5C
uniprot id: A0A2K5TZ21
uniprot id: A0A2K5TZ49
uniprot id: A0A2K5TZ66
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:LLGL2
gene id: 9541:LLGL2
uniprot id: A0A2K5TTW0
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9541:GRB7
gene id: 9541:GRB7
uniprot id: A0A2K5U3C0
uniprot id: A0A2K5U3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9541:ZKSCAN2
gene id: 9541:ZKSCAN2
uniprot id: A0A2K5WPZ5
uniprot id: G7Q0S1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:PEX2
gene id: 9541:PEX2
uniprot id: A0A2K5W3L5
uniprot id: A0A7N9D5I7
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9541:SH3GLB1
gene id: 9541:SH3GLB1
uniprot id: A0A2K5VM88
uniprot id: A0A7N9D5S5
uniprot id: A0A7N9DF74
uniprot id: G7NTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9541:LOC102123935
gene id: 9541:LOC102123935
uniprot id: Q9XT55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UDP-glycosyltransferase family.
messages: Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.
messages: Endoplasmic reticulum membrane
messages: Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.
messages: Microsome membrane
messages: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids.

9541:ELL
gene id: 9541:ELL
uniprot id: A0A2K5VPN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9541:MRPS9
gene id: 9541:MRPS9
uniprot id: A0A2K5WXZ9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9541:ENTPD8
gene id: 9541:ENTPD8
uniprot id: A0A2K5U016
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:GPI
gene id: 9541:GPI
uniprot id: A0A2K5W4A2
uniprot id: Q4R591
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer; in the catalytically active form. Monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9541:CPLX1
gene id: 9541:CPLX1
uniprot id: Q4R4N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complexin/synaphin family.
messages: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
messages: Perikaryon
messages: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).
messages: Presynapse
messages: cytosol

9541:TSHB
gene id: 9541:TSHB
uniprot id: A0A2K5X6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9541:MMP15
gene id: 9541:MMP15
uniprot id: A0A2K5U664
names: Similarity
messages: Belongs to the peptidase M10A family.

9541:SZRD1
gene id: 9541:SZRD1
uniprot id: A0A2K5TUQ7
uniprot id: A0A7N9CZQ5
names: Similarity
messages: Belongs to the SZRD1 family.

9541:GUCA2A
gene id: 9541:GUCA2A
uniprot id: A0A2K5UVW5
uniprot id: G7NUE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9541:PCMTD2
gene id: 9541:PCMTD2
uniprot id: A0A2K5U399
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9541:NEFL
gene id: 9541:NEFL
uniprot id: A0A2K5UWG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9541:TOP1
gene id: 9541:TOP1
uniprot id: A0A2K5W1H4
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9541:EXO5
gene id: 9541:EXO5
uniprot id: A0A8J8YFL1
uniprot id: G7NUD7
names: Similarity
messages: Belongs to the EXO5 family.

9541:NR2F2
gene id: 9541:NR2F2
uniprot id: A0A7N9D8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:SDC2
gene id: 9541:SDC2
uniprot id: I7G7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9541:ALDH8A1
gene id: 9541:ALDH8A1
uniprot id: A0A2K5TPT0
uniprot id: A0A2K5TPT1
uniprot id: A0A2K5TPV0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:TMEM91
gene id: 9541:TMEM91
uniprot id: A0A2K5UZP0
uniprot id: A0A7N9C7K4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:PPIP5K2
gene id: 9541:PPIP5K2
uniprot id: A0A2K5UZZ2
uniprot id: A0A2K5UZZ9
uniprot id: A0A2K5V009
uniprot id: A0A2K5V029
uniprot id: A0A8J8Y795
uniprot id: G7P809
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9541:CHST4
gene id: 9541:CHST4
uniprot id: A0A7N9CXJ4
uniprot id: Q4R9F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9541:EIF4A2
gene id: 9541:EIF4A2
uniprot id: Q4R4Y9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1 (By similarity).

9541:ECH1
gene id: 9541:ECH1
uniprot id: A0A2K5VDG5
uniprot id: A0A2K5VDI1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:LOC102129383
gene id: 9541:LOC102129383
uniprot id: A0A2K5WNE6
names: Similarity
messages: Belongs to the intermediate filament family.

9541:ADI1
gene id: 9541:ADI1
uniprot id: A0A2K5U577
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9541:CHRM2
gene id: 9541:CHRM2
uniprot id: A0A8J8XET9
uniprot id: G7P0W8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9541:CEBPE
gene id: 9541:CEBPE
uniprot id: A0A7N9D2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9541:CDKL1
gene id: 9541:CDKL1
uniprot id: A0A2K5WC50
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LOC102146894
gene id: 9541:LOC102146894
uniprot id: A0A2K5UMH9
names: Similarity
messages: Belongs to the histone H3 family.

9541:SH3BGRL
gene id: 9541:SH3BGRL
uniprot id: G7Q351
uniprot id: Q4R7R5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
messages: Belongs to the SH3BGR family.
messages: Cell membrane
messages: Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.
messages: The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding.
messages: cytosol

9541:CLIC2
gene id: 9541:CLIC2
uniprot id: G7Q239
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9541:EIF4EBP1
gene id: 9541:EIF4EBP1
uniprot id: A0A2K5X6X5
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9541:LYPLA1
gene id: 9541:LYPLA1
uniprot id: A0A2K5VFV7
uniprot id: A0A2K5VG09
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9541:CSAD
gene id: 9541:CSAD
uniprot id: A0A2K5UXF0
names: Similarity
messages: Belongs to the group II decarboxylase family.

9541:HTR1D
gene id: 9541:HTR1D
uniprot id: A0A2K5UMI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9541:ACVR1
gene id: 9541:ACVR1
uniprot id: A0A8J8XB86
uniprot id: G7PKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:IL15
gene id: 9541:IL15
uniprot id: A0A2K5VG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9541:SLC44A3
gene id: 9541:SLC44A3
uniprot id: A0A2K5UPP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9541:LOC101926433
gene id: 9541:LOC101926433
uniprot id: A0A2K5U698
uniprot id: A0A2K5U6B3
uniprot id: A0A2K5U6L3
uniprot id: P53601
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amyloid-beta peptides are degraded by IDE.
messages: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity).
messages: Belongs to the APP family.
messages: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu(2+) ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity). Isoform APP695 interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). Isoform APP770 interacts with SORL1 (By similarity). The C99 fragment also interacts with SORL1 (By similarity). Interacts with PLD3 (By similarity). Interacts with VDAC1 (By similarity). Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with LRRK2 (By similarity). Interacts (via cytoplasmic domain) with KIF5B (By similarity). Interacts (via C-terminus) with APB…
messages: Cell membrane
messages: Cell surface
messages: Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N- and O-glycosylated.
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members. In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis. Phosphorylation on Tyr-757 is required for SHC binding. Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin.
messages: Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-3, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.
messages: Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro). Amyloid-beta protein 40 and Amyloid-beta protein 42 are cleaved by ACE. Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase.
messages: Secreted
messages: Sulfated on tyrosine residues.
messages: The C-terminal region can bind zinc ions; this favors dimerization and formation of higher oligomers.
messages: The GFLD subdomain binds Cu(2+) ions; this promotes homodimerization.
messages: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The YENPXY site is also involved in clathrin-mediated endocytosis.
messages: The OX-2 motif shows some similarity to a region in the N-terminus of CD200/MOX2.
messages: The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells.
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: The transmembrane helix undergoes a conformation change and unravels partially when bound to PSEN1, facilitating cleavage by PSEN1.
messages: Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9541:TAMM41
gene id: 9541:TAMM41
uniprot id: A0A2K5U470
uniprot id: A0A2K5U4B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9541:CLDN19
gene id: 9541:CLDN19
uniprot id: A0A2K5UHK0
uniprot id: A0A7N9C8X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:IFNK
gene id: 9541:IFNK
uniprot id: G7PS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9541:TBX21
gene id: 9541:TBX21
uniprot id: A0A2K5W0N8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:ICMT
gene id: 9541:ICMT
uniprot id: A0A2K5UYR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:DOK6
gene id: 9541:DOK6
uniprot id: A0A2K5W216
uniprot id: A0A7N9CHL0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9541:PRICKLE2
gene id: 9541:PRICKLE2
uniprot id: A0A2K5X1F3
uniprot id: A0A2K5X1N1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9541:MYBBP1A
gene id: 9541:MYBBP1A
uniprot id: A0A2K5VX19
names: Similarity
messages: Belongs to the MYBBP1A family.

9541:LOC102114868
gene id: 9541:LOC102114868
uniprot id: A0A2K5W5C2
names: Subcellular Location Annotation
messages: Secreted

9541:DLG1
gene id: 9541:DLG1
uniprot id: A0A2K5TR33
uniprot id: A0A2K5TR55
uniprot id: A0A2K5TR59
uniprot id: A0A2K5TR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9541:SNW1
gene id: 9541:SNW1
uniprot id: A0A2K5TM10
uniprot id: A0A2K5TM20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9541:ACTL8
gene id: 9541:ACTL8
uniprot id: A0A8J8Y4N5
uniprot id: G7NUR7
names: Similarity
messages: Belongs to the actin family.

9541:HPSE
gene id: 9541:HPSE
uniprot id: A0A2K5UQU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9541:TMEM19
gene id: 9541:TMEM19
uniprot id: A0A2K5U1C6
uniprot id: G7PI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9541:MCM7
gene id: 9541:MCM7
uniprot id: Q4R3W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9541:HOXA2
gene id: 9541:HOXA2
uniprot id: A0A2K5X0V9
names: Subcellular Location Annotation
messages: Nucleus

9541:HARBI1
gene id: 9541:HARBI1
uniprot id: A0A2K5TZV8
uniprot id: G7PQB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9541:CRK
gene id: 9541:CRK
uniprot id: A0A2K5X7X9
names: Similarity
messages: Belongs to the CRK family.

9541:PLPP5
gene id: 9541:PLPP5
uniprot id: A0A2K5WD95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:PTTG1
gene id: 9541:PTTG1
uniprot id: A0A2K5WQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9541:MAPK6
gene id: 9541:MAPK6
uniprot id: A0A2K5U6X6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9541:DDX43
gene id: 9541:DDX43
uniprot id: A0A2K5VDJ5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:CLDN16
gene id: 9541:CLDN16
uniprot id: A0A2K5VEM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:FAM221B
gene id: 9541:FAM221B
uniprot id: A0A2K5TXZ4
uniprot id: G7PRZ1
names: Similarity
messages: Belongs to the FAM221 family.

9541:KEG98 p02
gene id: 9541:KEG98_p02
uniprot id: C3W4Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9541:PHYHIPL
gene id: 9541:PHYHIPL
uniprot id: A0A2K5WMU6
uniprot id: G7PDF2
names: Similarity
messages: Belongs to the PHYHIP family.

9541:AQP2
gene id: 9541:AQP2
uniprot id: A0A7N9CSL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:TLCD3A
gene id: 9541:TLCD3A
uniprot id: A0A2K5TJW7
names: Subcellular Location Annotation
messages: Membrane

9541:PDHA2
gene id: 9541:PDHA2
uniprot id: A0A2K5ULH9
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9541:SPATA24
gene id: 9541:SPATA24
uniprot id: Q4R7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPATA24 family.
messages: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).
messages: Cytoplasm
messages: Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2.
messages: nucleolus
messages: nucleoplasm

9541:TMEM218
gene id: 9541:TMEM218
uniprot id: A0A2K5VBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9541:HDAC2
gene id: 9541:HDAC2
uniprot id: A0A2K5TJ71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9541:MNAT1
gene id: 9541:MNAT1
uniprot id: A0A2K5UA85
uniprot id: A0A2K5UA91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9541:FXN
gene id: 9541:FXN
uniprot id: Q8HXX9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the frataxin family.
messages: Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Homodimer. Monomer (probable predominant form). Oligomer. Monomers and polymeric aggregates of >1 MDa have been isolated from mitochondria. A small fraction of heterologous overexpressed recombinant frataxin forms high-molecular weight aggregates that incorporate iron. Interacts with LYRM4. Interacts (via ferrous form) with ISCU; the interaction is possible when both are bound to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4) and the interaction enhances FXN interaction to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4) (By similarity). Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB (By similarity). Interacts with ACO2; the interaction is dependent on citrate (By similarity). Interacts with HSPA9 (By similarity).
messages: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation. May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (By similarity).
messages: Interacts with ACO1. Interacts with ISCU (cytoplasmic form).
messages: Mitochondrion
messages: Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival.
messages: Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to yield frataxin mature form (frataxin(81-210)) which is the predominant form. The additional forms, frataxin(56-210) and frataxin(78-210), seem to be produced when the normal maturation process is impaired; their physiological relevance is unsure.
messages: cytosol

9541:GDF3
gene id: 9541:GDF3
uniprot id: A0A2K5X0D5
names: Similarity
messages: Belongs to the TGF-beta family.

9541:IL1RL1
gene id: 9541:IL1RL1
uniprot id: A0A2K5UDB8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:KCNH6
gene id: 9541:KCNH6
uniprot id: A0A2K5X943
uniprot id: A0A2K5X9I4
names: Subcellular Location Annotation
messages: Membrane

9541:MED19
gene id: 9541:MED19
uniprot id: A0A2K5WF72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:SEPTIN6
gene id: 9541:SEPTIN6
uniprot id: A0A2K5W7M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:MAP3K21
gene id: 9541:MAP3K21
uniprot id: A0A2K5UG78
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9541:LOC102123903
gene id: 9541:LOC102123903
uniprot id: A0A2K5UGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ELSPBP1
gene id: 9541:ELSPBP1
uniprot id: A0A2K5UBA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FAM234B
gene id: 9541:FAM234B
uniprot id: A0A2K5TQD1
names: Similarity
messages: Belongs to the FAM234 family.

9541:DPEP1
gene id: 9541:DPEP1
uniprot id: A0A8J8YK92
uniprot id: G7PZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

9541:CDC42EP4
gene id: 9541:CDC42EP4
uniprot id: I7GEW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9541:LHCGR
gene id: 9541:LHCGR
uniprot id: A0A2K5V283
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9541:LOC102144646
gene id: 9541:LOC102144646
uniprot id: A0A8J8XP23
uniprot id: G7PVB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9541:GJD3
gene id: 9541:GJD3
uniprot id: A0A2K5UF43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:NUCB2
gene id: 9541:NUCB2
uniprot id: A0A2K5WKV7
uniprot id: A0A2K5WKW3
names: Similarity
messages: Belongs to the nucleobindin family.

9541:COQ3
gene id: 9541:COQ3
uniprot id: A0A2K5WFL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9541:RICTOR
gene id: 9541:RICTOR
uniprot id: A0A2K5V3Q7
uniprot id: A0A2K5V3T3
names: Similarity
messages: Belongs to the RICTOR family.

9541:CRYBB1
gene id: 9541:CRYBB1
uniprot id: A0A2K5TPY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9541:UBAC2
gene id: 9541:UBAC2
uniprot id: Q4R910
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with LMBR1L, FAF2, AMFR and VCP (By similarity).
messages: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity).

9541:ANXA3
gene id: 9541:ANXA3
uniprot id: A0A2K5W7S4
uniprot id: A0A8J8XSE0
uniprot id: G7P536
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:CWF19L1
gene id: 9541:CWF19L1
uniprot id: A0A2K5UUK7
uniprot id: A0A2K5UUP3
names: Similarity
messages: Belongs to the CWF19 family.

9541:ABI2
gene id: 9541:ABI2
uniprot id: A0A2K5UV69
uniprot id: A0A2K5UV84
uniprot id: A0A2K5UVD3
uniprot id: A0A7N9CIX9
uniprot id: A0A7N9D0E3
uniprot id: A0A7N9DC51
uniprot id: A0A7N9IF93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9541:SUPV3L1
gene id: 9541:SUPV3L1
uniprot id: A0A2K5WAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9541:LOC101865693
gene id: 9541:LOC101865693
uniprot id: A0A2K5W6Q3
uniprot id: A0A2K5W6R5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9541:NDRG2
gene id: 9541:NDRG2
uniprot id: A0A2K5V3C1
uniprot id: A0A2K5V3C6
uniprot id: Q4R4K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: Interacts with CTNNB1.
messages: growth cone
messages: perinuclear region

9541:LOC102116269
gene id: 9541:LOC102116269
uniprot id: A0A8J8YET7
uniprot id: G7PMI1
names: Similarity
messages: Belongs to the peptidase M67C family.

9541:HOXA11
gene id: 9541:HOXA11
uniprot id: A0A2K5VMG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:DYRK1B
gene id: 9541:DYRK1B
uniprot id: A0A2K5X0W6
uniprot id: A0A2K5X0X0
uniprot id: A0A2K5X145
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9541:GML
gene id: 9541:GML
uniprot id: A0A2K5TTQ8
uniprot id: G7PD28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:TMEM126A
gene id: 9541:TMEM126A
uniprot id: A0A8J8YQX2
uniprot id: G7PND4
names: Subcellular Location Annotation
messages: Membrane

9541:PGS1
gene id: 9541:PGS1
uniprot id: A0A2K5V667
uniprot id: G7PSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9541:MME
gene id: 9541:MME
uniprot id: A0A8J8YT08
uniprot id: G7NZK8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9541:HOMER3
gene id: 9541:HOMER3
uniprot id: A0A2K5UW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9541:CFAP91
gene id: 9541:CFAP91
uniprot id: A0A2K5UJB2
names: Similarity
messages: Belongs to the CFAP91 family.

9541:RPS6KA1
gene id: 9541:RPS6KA1
uniprot id: A0A2K5VR69
uniprot id: A0A2K5VRG4
uniprot id: A0A7N9CZK0
uniprot id: A0A7N9IFX3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:LRRC42
gene id: 9541:LRRC42
uniprot id: A0A2K5V482
uniprot id: A0A7N9IFT9
names: Similarity
messages: Belongs to the LRRC42 family.

9541:AMFR
gene id: 9541:AMFR
uniprot id: A0A2K5VXW5
names: Subcellular Location Annotation
messages: Membrane

9541:KCTD13
gene id: 9541:KCTD13
uniprot id: A0A2K5WU44
names: Subcellular Location Annotation
messages: Cell membrane

9541:CDS1
gene id: 9541:CDS1
uniprot id: A0A2K5TXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9541:MYRF
gene id: 9541:MYRF
uniprot id: A0A2K5X472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9541:B4GALT7
gene id: 9541:B4GALT7
uniprot id: A0A2K5U1V7
uniprot id: A0A2K5U1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:HM13
gene id: 9541:HM13
uniprot id: A0A2K5WN40
uniprot id: A0A2K5WN78
uniprot id: G7PGP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9541:ZNF684
gene id: 9541:ZNF684
uniprot id: Q4R6J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:SLC35B4
gene id: 9541:SLC35B4
uniprot id: Q95KB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Golgi apparatus membrane
messages: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

9541:LIMS1
gene id: 9541:LIMS1
uniprot id: A0A2K5U284
uniprot id: A0A2K5U288
uniprot id: A0A8J8XB79
uniprot id: G7PMX1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9541:TEKT2
gene id: 9541:TEKT2
uniprot id: A0A2K5WAH2
uniprot id: G7NTH9
uniprot id: Q4R5V1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tektin family.
messages: May interact with CCDC172.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
messages: Tyrosine phosphorylated.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme
messages: microtubule organizing center

9541:SCIN
gene id: 9541:SCIN
uniprot id: A0A2K5ULY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9541:KIF16B
gene id: 9541:KIF16B
uniprot id: A0A2K5U450
uniprot id: A0A2K5U453
uniprot id: A0A2K5U469
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:SH3BP5L
gene id: 9541:SH3BP5L
uniprot id: A0A2K5WLD2
uniprot id: G7NVJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9541:DBH
gene id: 9541:DBH
uniprot id: A0A2K5WW80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Conversion of dopamine to noradrenaline.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9541:SKP1
gene id: 9541:SKP1
uniprot id: I7G2L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9541:JAKMIP2
gene id: 9541:JAKMIP2
uniprot id: A0A2K5VY94
uniprot id: A0A2K5VYD8
names: Similarity
messages: Belongs to the JAKMIP family.

9541:UCHL1
gene id: 9541:UCHL1
uniprot id: I7GJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CRISP1
gene id: 9541:CRISP1
uniprot id: A0A2K5U1H1
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RPAP1
gene id: 9541:RPAP1
uniprot id: A0A2K5VZ95
names: Similarity
messages: Belongs to the RPAP1 family.

9541:AAR2
gene id: 9541:AAR2
uniprot id: A0A2K5UQQ1
uniprot id: A0A7N9CY04
uniprot id: Q4R7D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.
messages: Interacts with PRPF8 (via RNase H homology domain) (By similarity). Component of a U5 snRNP complex that contains PRPF8 (By similarity).

9541:AIG1
gene id: 9541:AIG1
uniprot id: A0A2K5UG94
uniprot id: A0A2K5UGC1
uniprot id: A0A2K5UGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9541:CTSB
gene id: 9541:CTSB
uniprot id: G7PCE3
uniprot id: Q4R5M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1.
messages: Lysosome
messages: Melanosome
messages: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).
messages: extracellular space

9541:RPS6
gene id: 9541:RPS6
uniprot id: Q4R4K6
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
messages: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
messages: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.

9541:EMC10
gene id: 9541:EMC10
uniprot id: A0A2K5X7T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9541:LOC102147063
gene id: 9541:LOC102147063
uniprot id: A0A2K5U027
uniprot id: A0A2K5U042
names: Similarity
messages: Belongs to the folate receptor family.

9541:GPR15
gene id: 9541:GPR15
uniprot id: A0A2K5UFW2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:TPD52L1
gene id: 9541:TPD52L1
uniprot id: A0A2K5X0K9
uniprot id: A0A2K5X0T1
uniprot id: A0A2K5X0T6
uniprot id: A0A2K5X0W8
uniprot id: A0A2K5X164
uniprot id: A0A8J8XXK1
uniprot id: G7P385
uniprot id: I7GIB6
names: Similarity
messages: Belongs to the TPD52 family.

9541:LIG1
gene id: 9541:LIG1
uniprot id: A0A2K5UH62
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

9541:STT3A
gene id: 9541:STT3A
uniprot id: A0A8J8XKB3
uniprot id: G7PPM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9541:CDC123
gene id: 9541:CDC123
uniprot id: G7PED6
uniprot id: Q2PG37
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Phosphorylated.
messages: Required for S phase entry of the cell cycle.

9541:LOC102131765
gene id: 9541:LOC102131765
uniprot id: A0A2K5WCF2
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.